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Conserved domains on  [gi|2158165366|ref|WP_230581220|]
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MULTISPECIES: HAMP domain-containing sensor histidine kinase [Bifidobacterium]

Protein Classification

sensor histidine kinase( domain architecture ID 11428264)

sensor histidine kinase is part of a two-component regulatory system and functions as a protein kinase that phosphorylates a target protein in response to a signal

EC:  2.7.13.3
Gene Ontology:  GO:0004673|GO:0007165|GO:0005524|GO:0000160|GO:0016020|GO:0000155
PubMed:  11489844|18076326|10966457|11406410|12372152|8029829

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
3-195 5.83e-41

Signal transduction histidine kinase [Signal transduction mechanisms];


:

Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 141.20  E-value: 5.83e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366   3 ETTLDEEQKLYLSYAMRSSEQMRRYIKMMIDISRA-SCGYQLQMEDICFPEFWRHVISQAEIICKDKGIVIQQTQHALPK 81
Cdd:COG0642   136 LEELDEEQREYLETILRSADRLLRLINDLLDLSRLeAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLP 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  82 HITGDRVLLERALMNVVSNAVEHSPVDSPLYMDADGQGDHLNICITDCGCGFSQEALKHAKERFYMADQSRGSElHYGMG 161
Cdd:COG0642   216 TVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGG-GTGLG 294

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2158165366 162 LYIVDVIIKQHRGELLLSnSAETKGARVTIRLPR 195
Cdd:COG0642   295 LAIVKRIVELHGGTIEVE-SEPGKGTTFTVTLPL 327
 
Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
3-195 5.83e-41

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 141.20  E-value: 5.83e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366   3 ETTLDEEQKLYLSYAMRSSEQMRRYIKMMIDISRA-SCGYQLQMEDICFPEFWRHVISQAEIICKDKGIVIQQTQHALPK 81
Cdd:COG0642   136 LEELDEEQREYLETILRSADRLLRLINDLLDLSRLeAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLP 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  82 HITGDRVLLERALMNVVSNAVEHSPVDSPLYMDADGQGDHLNICITDCGCGFSQEALKHAKERFYMADQSRGSElHYGMG 161
Cdd:COG0642   216 TVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGG-GTGLG 294

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2158165366 162 LYIVDVIIKQHRGELLLSnSAETKGARVTIRLPR 195
Cdd:COG0642   295 LAIVKRIVELHGGTIEVE-SEPGKGTTFTVTLPL 327
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 86-192 1.91e-28

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 102.54  E-value: 1.91e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  86 DRVLLERALMNVVSNAVEHSPVDSPLYMDADGQGDHLNICITDCGCGFSQEALKHAKERFYMADQSRGSELHYGMGLYIV 165
Cdd:cd16975     1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGHYGMGLYIA 80

                          90       100
                  ....*....|....*....|....*..
gi 2158165366 166 DVIIKQHRGELLLSNSaETKGARVTIR 192
Cdd:cd16975    81 KNLVEKHGGSLIIENS-QKGGAEVTVK 106
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 85-194 1.53e-25

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 95.02  E-value: 1.53e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366   85 GDRVLLERALMNVVSNAVEHSPVDSPLYMDADGQGDHLNICITDCGCGFSQEALKHAKERFYMADQSRGSELHYGMGLYI 164
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIGGTGLGLSI 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 2158165366  165 VDVIIKQHRGELLLsNSAETKGARVTIRLP 194
Cdd:smart00387  81 VKKLVELHGGEISV-ESEPGGGTTFTITLP 109
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 85-194 3.36e-22

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 86.27  E-value: 3.36e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  85 GDRVLLERALMNVVSNAVEHSPVDSPLYMDADgQGDHLNICITDCGCGFSQEALKHAKERFYMADQSRGSElhYGMGLYI 164
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLS-EGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGGG--TGLGLSI 77

                          90       100       110
                  ....*....|....*....|....*....|
gi 2158165366 165 VDVIIKQHRGELLLSnSAETKGARVTIRLP 194
Cdd:pfam02518  78 VRKLVELLGGTITVE-SEPGGGTTVTLTLP 106
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 19-195 2.68e-18

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 81.81  E-value: 2.68e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  19 RSSEQMRRYIKMMIDISRASCGYQLQ-MEDICFPEFWRHVISQAEIICKDKGIVIQQtqHALPKHITGDRVLLERALMNV 97
Cdd:PRK11100  299 TQSARLQQLIDRLLELARLEQRQELEvLEPVALAALLEELVEAREAQAAAKGITLRL--RPDDARVLGDPFLLRQALGNL 376

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  98 VSNAVEHSPVDSPLYMDADGQGDHLNICITDCGCGFSQEALKHAKERFY----MADQSRGSelhyGMGLYIVDVIIKQHR 173
Cdd:PRK11100  377 LDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERFYslprPANGRKST----GLGLAFVREVARLHG 452

                         170       180
                  ....*....|....*....|..
gi 2158165366 174 GELLLSNsAETKGARVTIRLPR 195
Cdd:PRK11100  453 GEVTLRN-RPEGGVLATLTLPR 473
 
Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
3-195 5.83e-41

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 141.20  E-value: 5.83e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366   3 ETTLDEEQKLYLSYAMRSSEQMRRYIKMMIDISRA-SCGYQLQMEDICFPEFWRHVISQAEIICKDKGIVIQQTQHALPK 81
Cdd:COG0642   136 LEELDEEQREYLETILRSADRLLRLINDLLDLSRLeAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLP 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  82 HITGDRVLLERALMNVVSNAVEHSPVDSPLYMDADGQGDHLNICITDCGCGFSQEALKHAKERFYMADQSRGSElHYGMG 161
Cdd:COG0642   216 TVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGG-GTGLG 294

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2158165366 162 LYIVDVIIKQHRGELLLSnSAETKGARVTIRLPR 195
Cdd:COG0642   295 LAIVKRIVELHGGTIEVE-SEPGKGTTFTVTLPL 327
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
2-195 9.63e-40

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 135.42  E-value: 9.63e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366   2 DETTLDEEQKLYLSYAMRSSEQMRRYIKMMIDISRASCG-YQLQMEDICFPEFWRHVISQAEIICKDKGIVIQQTQHALP 80
Cdd:COG2205    44 EEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLESGkLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPEL 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  81 KHITGDRVLLERALMNVVSNAVEHSPVDSPLYMDADGQGDHLNICITDCGCGFSQEALKHAKERFYMADQSRGSElHYGM 160
Cdd:COG2205   124 PLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEG-GTGL 202

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2158165366 161 GLYIVDVIIKQHRGELLLSnSAETKGARVTIRLPR 195
Cdd:COG2205   203 GLAIVKRIVEAHGGTIWVE-SEPGGGTTFTVTLPL 236
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
1-195 2.76e-38

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 135.45  E-value: 2.76e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366   1 MDETTLDEEQKLYLSYAMRSSEQMRRYIKMMIDISRA-SCGYQLQMEDICFPEFWRHVISQAEIICKDKGIVIQQTQHAL 79
Cdd:COG5002   192 DGAADDPEERREYLEIILEEAERLSRLVNDLLDLSRLeSGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPED 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  80 PKHITGDRVLLERALMNVVSNAVEHSPVDSPLYMDADGQGDHLNICITDCGCGFSQEALKHAKERFYMADQSRGSELH-Y 158
Cdd:COG5002   272 PLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGgT 351

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 2158165366 159 GMGLYIVDVIIKQHRGELLLSnSAETKGARVTIRLPR 195
Cdd:COG5002   352 GLGLAIVKHIVEAHGGRIWVE-SEPGKGTTFTITLPL 387
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 86-192 1.91e-28

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 102.54  E-value: 1.91e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  86 DRVLLERALMNVVSNAVEHSPVDSPLYMDADGQGDHLNICITDCGCGFSQEALKHAKERFYMADQSRGSELHYGMGLYIV 165
Cdd:cd16975     1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGHYGMGLYIA 80

                          90       100
                  ....*....|....*....|....*..
gi 2158165366 166 DVIIKQHRGELLLSNSaETKGARVTIR 192
Cdd:cd16975    81 KNLVEKHGGSLIIENS-QKGGAEVTVK 106
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 85-194 1.53e-25

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 95.02  E-value: 1.53e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366   85 GDRVLLERALMNVVSNAVEHSPVDSPLYMDADGQGDHLNICITDCGCGFSQEALKHAKERFYMADQSRGSELHYGMGLYI 164
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIGGTGLGLSI 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 2158165366  165 VDVIIKQHRGELLLsNSAETKGARVTIRLP 194
Cdd:smart00387  81 VKKLVELHGGEISV-ESEPGGGTTFTITLP 109
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 7-195 1.30e-23

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 96.57  E-value: 1.30e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366   7 DEEQKLYLSYAMRSSEQMRRYIKMMIDISRAScgyQLQMEDICFPEFWRHVISQAEIICKDKGIVIQQTQHALPKHITGD 86
Cdd:COG5000   238 REDLERALDTIIRQVDRLKRIVDEFLDFARLP---EPQLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLPEVLAD 314

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  87 RVLLERALMNVVSNAVEHSPVDSPLYMDADGQGDHLNICITDCGCGFSQEALKHAKERFYmADQSRGSelhyGMGLYIVD 166
Cdd:COG5000   315 RDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFF-TTKPKGT----GLGLAIVK 389

                         170       180
                  ....*....|....*....|....*....
gi 2158165366 167 VIIKQHRGELLLSNSAEtKGARVTIRLPR 195
Cdd:COG5000   390 KIVEEHGGTIELESRPG-GGTTFTIRLPL 417
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 85-194 3.36e-22

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 86.27  E-value: 3.36e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  85 GDRVLLERALMNVVSNAVEHSPVDSPLYMDADgQGDHLNICITDCGCGFSQEALKHAKERFYMADQSRGSElhYGMGLYI 164
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLS-EGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGGG--TGLGLSI 77

                          90       100       110
                  ....*....|....*....|....*....|
gi 2158165366 165 VDVIIKQHRGELLLSnSAETKGARVTIRLP 194
Cdd:pfam02518  78 VRKLVELLGGTITVE-SEPGGGTTVTLTLP 106
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 90-194 2.64e-20

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 81.22  E-value: 2.64e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  90 LERALMNVVSNAVEHSPvdSPLYMDADGQGDHLNICITDCGCGFSQEALKHAKERFYMADQSRGSELH-YGMGLYIVDVI 168
Cdd:cd16949     1 LARALENVLRNALRYSP--SKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGgTGLGLAIAERA 78

                          90       100
                  ....*....|....*....|....*.
gi 2158165366 169 IKQHRGELLLSNSaETKGARVTIRLP 194
Cdd:cd16949    79 IEQHGGKIKASNR-KPGGLRVRIWLP 103
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 6-195 8.02e-20

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 86.38  E-value: 8.02e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366   6 LDEEQKLYLSYAMRSSEQMRRYIKMMIDISRAScGYQLQMEDICFPEFWRHVISQAEIICKDKGIVIqqTQHALPkHITG 85
Cdd:COG4251   315 LDEEGREYLERIRDAAERMQALIDDLLAYSRVG-RQELEFEPVDLNELLEEVLEDLEPRIEERGAEI--EVGPLP-TVRG 390

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  86 DRVLLERALMNVVSNAVEHSPVDSP--LYMDADGQGDHLNICITDCGCGFSQEAlkHAK-----ERFYMADQSRGSelhy 158
Cdd:COG4251   391 DPTLLRQVFQNLISNAIKYSRPGEPprIEIGAEREGGEWVFSVRDNGIGIDPEY--AEKifeifQRLHSRDEYEGT---- 464

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 2158165366 159 GMGLYIVDVIIKQHRGELLLSnSAETKGARVTIRLPR 195
Cdd:COG4251   465 GIGLAIVKKIVERHGGRIWVE-SEPGEGATFYFTLPK 500
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 19-195 2.68e-18

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 81.81  E-value: 2.68e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  19 RSSEQMRRYIKMMIDISRASCGYQLQ-MEDICFPEFWRHVISQAEIICKDKGIVIQQtqHALPKHITGDRVLLERALMNV 97
Cdd:PRK11100  299 TQSARLQQLIDRLLELARLEQRQELEvLEPVALAALLEELVEAREAQAAAKGITLRL--RPDDARVLGDPFLLRQALGNL 376

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  98 VSNAVEHSPVDSPLYMDADGQGDHLNICITDCGCGFSQEALKHAKERFY----MADQSRGSelhyGMGLYIVDVIIKQHR 173
Cdd:PRK11100  377 LDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERFYslprPANGRKST----GLGLAFVREVARLHG 452

                         170       180
                  ....*....|....*....|..
gi 2158165366 174 GELLLSNsAETKGARVTIRLPR 195
Cdd:PRK11100  453 GEVTLRN-RPEGGVLATLTLPR 473
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 1-195 4.01e-18

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 80.61  E-value: 4.01e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366   1 MDETTLDEEQKLYLSYAMRSSEQMRRYIKMMIDISRAScgyQLQMEDICFPEFWRHVISQAEIICKDKGI-VIQQTQHAL 79
Cdd:COG4191   171 LEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRD---EEEREPVDLNELIDEALELLRPRLKARGIeVELDLPPDL 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  80 PKhITGDRVLLERALMNVVSNAVE--HSPVDSPLYMDADGQGDHLNICITDCGCGFSQEALKHAKERFY-MADQSRGSel 156
Cdd:COG4191   248 PP-VLGDPGQLEQVLLNLLINAIDamEEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFtTKPVGKGT-- 324

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2158165366 157 hyGMGLYIVDVIIKQHRGELLLSnSAETKGARVTIRLPR 195
Cdd:COG4191   325 --GLGLSISYGIVEKHGGRIEVE-SEPGGGTTFTITLPL 360
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 77-193 9.33e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 69.74  E-value: 9.33e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  77 HALPKHITGDRVLLERALMNVVSNAVEHSPVDSPLYMDADGQgDHLNICITDCGCGFSQEALKHAKERFYMADQS--RGS 154
Cdd:cd16940     1 SAADIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSAD-DGAVIRVEDNGPGIDEEELEALFERFYRSDGQnyGGS 79

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2158165366 155 elhyGMGLYIVDVIIKQHRGELLLSNsAETKGARVTIRL 193
Cdd:cd16940    80 ----GLGLSIVKRIVELHGGQIFLGN-AQGGGLEAWVRL 113
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
22-194 1.28e-14

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 71.12  E-value: 1.28e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  22 EQMrryIKMMIDISRASCGYQLQMEDICFPEFWRHVISQAEIICKDKGIVIQQTQHALPKHITGDRVLLERALMNVVSNA 101
Cdd:PRK09470  289 DSM---INDLLVLSRNQQKNHLERETFKANSLWSEVLEDAKFEAEQMGKSLTVSAPPGPWPINGNPNALASALENIVRNA 365

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366 102 VE--HSPVDSPLYMDADGqgdhLNICITDCGCGFSQEALKHAKERFYMADQSR-----GSelhyGMGLYIVDVIIKQHRG 174
Cdd:PRK09470  366 LRysHTKIEVAFSVDKDG----LTITVDDDGPGVPEEEREQIFRPFYRVDEARdresgGT----GLGLAIVENAIQQHRG 437

                         170       180
                  ....*....|....*....|
gi 2158165366 175 ELLLSNSAeTKGARVTIRLP 194
Cdd:PRK09470  438 WVKAEDSP-LGGLRLTIWLP 456
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 90-176 2.77e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 60.48  E-value: 2.77e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  90 LERALMNVVSNAVEHSPVDSPLYMDADGQGDHLNICITDCGCGFSQEALKHAKERFYMADQSRGSElHYGMGLYIVDVII 169
Cdd:cd16923     1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRNTE-GAGLGLSIAKAII 79


                  ....*..
gi 2158165366 170 KQHRGEL 176
Cdd:cd16923    80 ELHGGSA 86
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 90-194 5.56e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 59.91  E-value: 5.56e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  90 LERALMNVVSNAVEHSPVDSPLYM--DADGQGDHLNicITDCGCGFSQEALKHAKERFYMADQSRGSELH-YGMGLYIVD 166
Cdd:cd16952     1 LRSAFSNLVSNAVKYTPPSDTITVrwSQEESGARLS--VEDTGPGIPPEHIPRLTERFYRVDIERCRNTGgTGLGLAIVK 78

                          90       100
                  ....*....|....*....|....*...
gi 2158165366 167 VIIKQHRGELLLSnSAETKGARVTIRLP 194
Cdd:cd16952    79 HVMSRHDARLLIA-SELGKGSRFTCLFP 105
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 86-194 1.16e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 58.70  E-value: 1.16e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  86 DRVLLERALMNVVSNA---VEHSPVDSP---LYMDADGQGDhLNICITDCGCGFSQEALKHAKERfYMADQSRGSelhyG 159
Cdd:cd16944     1 DTTQISQVLTNILKNAaeaIEGRPSDVGevrIRVEADQDGR-IVLIVCDNGKGFPREMRHRATEP-YVTTRPKGT----G 74

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2158165366 160 MGLYIVDVIIKQHRGELLLSNsAETKGARVTIRLP 194
Cdd:cd16944    75 LGLAIVKKIMEEHGGRISLSN-REAGGACIRIILP 108
PRK10604 PRK10604
sensor protein RstB; Provisional
 43-194 1.61e-11

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 61.93  E-value: 1.61e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  43 LQMEDICFPEFWRHVISQAEIICKDKGIVIQQTQHALPkhITGDRVLLERALMNVVSNAVEHSpvDSPLYMDADGQGDHL 122
Cdd:PRK10604  275 LHLSEPDLPAWLSTHLADIQAVTPEKTVRLDTPHQGDY--GALDMRLMERVLDNLLNNALRYA--HSRVRVSLLLDGNQA 350

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2158165366 123 NICITDCGCGFSQEALKHAKERFYMADQSRG-SELHYGMGLYIVDVIIKQHRGELLLsNSAETKGARVTIRLP 194
Cdd:PRK10604  351 CLIVEDDGPGIPPEERERVFEPFVRLDPSRDrATGGCGLGLAIVHSIALAMGGSVNC-DESELGGARFSFSWP 422
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
83-195 2.57e-11

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 61.71  E-value: 2.57e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  83 ITGDRVLLERALMNVVSNAVEHSPVDSPLYMDADGQGDHLNICITDCGCGFSQEALKHAKERFYMADQSR-----GSelh 157
Cdd:PRK09835  369 VAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRqrkgeGS--- 445

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2158165366 158 yGMGLYIVDVIIKQHRGELLLSNSAetKGARVTIRLPR 195
Cdd:PRK09835  446 -GIGLAIVKSIVVAHKGTVAVTSDA--RGTRFVISLPR 480
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
23-195 2.92e-11

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 61.14  E-value: 2.92e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  23 QMRRYIKMMIDISRA----SCGYQLQM---EDICFPefwrhviSQAEI--ICKDKGIVIQQTQHALPKHITGDRVLLERA 93
Cdd:PRK10755  179 QMMHTVEQLLQLARAgqsfSSGHYQTVkllEDVILP-------SQDELseMLEQRQQTLLLPESAADITVQGDATLLRLL 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  94 LMNVVSNAVEHSPVDSPLYMDADGQGDHLNICITDCGCGFSQEALKHAKERFYMADQSRGSelhYGMGLYIVDVIIKQHR 173
Cdd:PRK10755  252 LRNLVENAHRYSPEGSTITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRMDSRYGG---IGLGLSIVSRITQLHH 328

                         170       180
                  ....*....|....*....|..
gi 2158165366 174 GELLLSNSAETKGARVTIRLPR 195
Cdd:PRK10755  329 GQFFLQNRQERSGTRAWVWLPK 350
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
7-194 3.96e-11

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 60.63  E-value: 3.96e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366   7 DEEQKLYLSYAMRSSEQMRRYIKMMIDISRASCGyQLQMEDICfpEFWRHVIS--QAEIickDKGIVIQ-QTQHALPkHI 83
Cdd:COG3852   166 DDELREYTQLIIEEADRLNNLVDRLLSFSRPRPP-EREPVNLH--EVLERVLEllRAEA---PKNIRIVrDYDPSLP-EV 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  84 TGDRVLLERALMNVVSNAVEHSP----------VDSPLYMDADGQGDHLNICITDCGCGFSQEALKH-------AKErfy 146
Cdd:COG3852   239 LGDPDQLIQVLLNLVRNAAEAMPeggtitirtrVERQVTLGGLRPRLYVRIEVIDNGPGIPEEILDRifepfftTKE--- 315

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2158165366 147 madqsRGSelhyGMGLYIVDVIIKQHRGELLLSnSAETKGARVTIRLP 194
Cdd:COG3852   316 -----KGT----GLGLAIVQKIVEQHGGTIEVE-SEPGKGTTFRIYLP 353
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 86-191 5.81e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 57.09  E-value: 5.81e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  86 DRVLLERALMNVVSNAVEHSPVDSPLYMDADGQGDHLNICITDCGCGFSQEALKHAKERFYMADQSRGSELHYGMGLYIV 165
Cdd:cd16945     1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQKSTGLGLAFV 80

                          90       100
                  ....*....|....*....|....*.
gi 2158165366 166 DVIIKQHRGELLLSNSAETKGARVTI 191
Cdd:cd16945    81 QEVAQLHGGRITLRNRPDGVLAFLTL 106
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 90-194 6.61e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 56.81  E-value: 6.61e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  90 LERALMNVVSNAVEHSPVDS-PLYMDADGQGDHLNICITDCGCGFSQEALKHAKERFYmADQSRGSEL--HYGMGLYIVD 166
Cdd:cd16953     1 LGQVLRNLIGNAISFSPPDTgRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFY-TERPANEAFgqHSGLGLSISR 79

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2158165366 167 VIIKQHRGELLLSN---SAETKGARVTIRLP 194
Cdd:cd16953    80 QIIEAHGGISVAENhnqPGQVIGARFTVQLP 110
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 65-195 1.66e-10

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 59.09  E-value: 1.66e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  65 CKDKGIVIQQTQHALPKHITGDRVLLERALMNVVSNAVEH---SPVDSP-LYMDADGQGDHLNICITDCGCGFSQEALKH 140
Cdd:COG3290   257 ARERGIDLTIDIDSDLPDLPLSDTDLVTILGNLLDNAIEAvekLPEEERrVELSIRDDGDELVIEVEDSGPGIPEELLEK 336

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2158165366 141 AKERFYMADQSRGSelhyGMGLYIVDVIIKQHRGELLLSnSAETKGARVTIRLPR 195
Cdd:COG3290   337 IFERGFSTKLGEGR----GLGLALVKQIVEKYGGTIEVE-SEEGEGTVFTVRLPK 386
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 94-194 3.71e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 54.81  E-value: 3.71e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  94 LMNVVSNAV---EHSPVDSPLY-MDADGQGDHLNICITDCGCGFSQEALKHAKERFYMADQS-----RGSelhyGMGLYI 164
Cdd:cd16922     5 LLNLLGNAIkftEEGEVTLRVSlEEEEEDGVQLRFSVEDTGIGIPEEQQARLFEPFSQADSSttrkyGGT----GLGLAI 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 2158165366 165 VDVIIKQHRGELLLSnSAETKGARVTIRLP 194
Cdd:cd16922    81 SKKLVELMGGDISVE-SEPGQGSTFTFTLP 109
envZ PRK09467
osmolarity sensor protein; Provisional
 71-194 4.02e-10

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 58.00  E-value: 4.02e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  71 VIQQTQHALPKHITGDRVLLERALMNVVSNAVE--HSPVDSPLYMDadgqGDHLNICITDCGCGFSQEALKHAKERFYMA 148
Cdd:PRK09467  313 EIETALQPGPIEVPMNPIAIKRALANLVVNAARygNGWIKVSSGTE----GKRAWFQVEDDGPGIPPEQLKHLFQPFTRG 388

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2158165366 149 DQSRGSElHYGMGLYIVDVIIKQHRGELLLSNSAEtKGARVTIRLP 194
Cdd:PRK09467  389 DSARGSS-GTGLGLAIVKRIVDQHNGKVELGNSEE-GGLSARAWLP 432
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 97-194 5.78e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 54.21  E-value: 5.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  97 VVSNAVEHSPVDSPLYMDADGQGDHLNICITDCGCGFSQEALKHAKERFYMADQSRGSELHYGMGLYIVDVIIKQhRGEL 176
Cdd:cd16948    13 IVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQESTGMGLYLVKKLCDK-LGHK 91

                          90
                  ....*....|....*...
gi 2158165366 177 LLSNSAETKGARVTIRLP 194
Cdd:cd16948    92 IDVESEVGEGTTFTITFP 109
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
1-195 8.39e-10

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 57.29  E-value: 8.39e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366   1 MDETTLDEEQKlYLSYAMRSSEQMRRYIKMMIDISRAScgyQLQMEDICFPEFWRHVISQAEIICKDKGIVIQ-QTQHAL 79
Cdd:PRK11360  416 RQQTSDPPSQE-YLSVVLREVDRLNKVIDQLLEFSRPR---ESQWQPVSLNALVEEVLQLFQTAGVQARVDFEtELDNEL 491

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  80 PKhITGDRVLLERALMNVVSNAVEHSP------VDSPLYMDadgqgDHLNICITDCGCGFSQEALKHAKERFYmADQSRG 153
Cdd:PRK11360  492 PP-IWADPELLKQVLLNILINAVQAISargkirIRTWQYSD-----GQVAVSIEDNGCGIDPELLKKIFDPFF-TTKAKG 564

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 2158165366 154 SelhyGMGLYIVDVIIKQHRGELLLSnSAETKGARVTIRLPR 195
Cdd:PRK11360  565 T----GLGLALSQRIINAHGGDIEVE-SEPGVGTTFTLYLPI 601
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 90-194 2.09e-09

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 53.15  E-value: 2.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  90 LERALMNVVSNA---------------VEHSPVDSPLYMDADGQGDHLNICITDCGCGFSQEALKHAKERFYMADQ-SRG 153
Cdd:cd16919     1 LELAILNLAVNArdampeggrltietsNQRVDADYALNYRDLIPGNYVCLEVSDTGSGMPAEVLRRAFEPFFTTKEvGKG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2158165366 154 SelhyGMGLYIVDVIIKQHRGELLLsNSAETKGARVTIRLP 194
Cdd:cd16919    81 T----GLGLSMVYGFVKQSGGHLRI-YSEPGVGTTVRIYLP 116
PRK10490 PRK10490
sensor protein KdpD; Provisional
 26-194 2.20e-09

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 56.20  E-value: 2.20e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  26 RYIKMMIDISR-ASCGYQLQMEdicfpefWRhviSQAEIIckdkGIVIQQTQHALPKH------------ITGDRVLLER 92
Cdd:PRK10490  716 RLVNNLLDMARiQSGGFNLRKE-------WL---TLEEVV----GSALQMLEPGLSGHpinlslpepltlIHVDGPLFER 781

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  93 ALMNVVSNAVEHSPVDSPLYMDADGQGDHLNICITDCGCGFSQEALKHAKERFymadqSRGSELH----YGMGLYIVDVI 168
Cdd:PRK10490  782 VLINLLENAVKYAGAQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKF-----ARGNKESaipgVGLGLAICRAI 856

                         170       180
                  ....*....|....*....|....*.
gi 2158165366 169 IKQHRGELLLSNSAEtKGARVTIRLP 194
Cdd:PRK10490  857 VEVHGGTIWAENRPE-GGACFRVTLP 881
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 73-194 5.80e-09

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 54.69  E-value: 5.80e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  73 QQTQHALPKH--ITGDRVLLERALMNVVSNAVEHSPVDSPLYMDADGQGDHLNICITDCGCGFsqEALKHAKERFYMAdq 150
Cdd:COG4192   525 QQITLHIPDDlmVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGW--PLVDKLFTPFTTT-- 600

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2158165366 151 srgSELHYGMGLYIVDVIIKQHRGELLLSnSAETKGARVTIRLP 194
Cdd:COG4192   601 ---KEVGLGLGLSICRSIMQQFGGDLYLA-STLERGAMVILEFN 640
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 90-182 9.11e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 50.91  E-value: 9.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  90 LERALMNVVSNAVEHSpvDSPLYMDADGQGDHLNICITDCGCGFSQEALKHAKERFYMADQSRGSElHYGMGLYIVDVII 169
Cdd:cd16950     1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGTS-GTGLGLAIVQRIS 77

                          90
                  ....*....|...
gi 2158165366 170 KQHRGELLLSNSA 182
Cdd:cd16950    78 DAHGGSLTLANRA 90
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
55-194 1.44e-08

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 53.64  E-value: 1.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  55 RHVISQAEIICKDKGIVIQQTQHALPKHITGDRVLLERALMNVVSNAVEHSPVDSPLYMDADGQGDHLNICITDCGCGFS 134
Cdd:PRK10364  314 NHSLQLVSQDANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIA 393

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2158165366 135 QEALKHAkerF--YMADQSRGSelhyGMGLYIVDVIIKQHRGELLLSnSAETKGARVTIRLP 194
Cdd:PRK10364  394 ADQLEAI---FtpYFTTKAEGT----GLGLAVVHNIVEQHGGTIQVA-SQEGKGATFTLWLP 447
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
22-194 1.75e-08

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 53.09  E-value: 1.75e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  22 EQMRRY---IKMMIDISRASCGYQLQMEDIC-FPEFWRHVISQAEIICKDKGIVIQQTQHALpkHITGDRVLLERALMNV 97
Cdd:PRK11006  248 EQTQRMeglVKQLLTLSKIEAAPTIDLNEKVdVPMMLRVLEREAQTLSQGKHTITFEVDNSL--KVFGNEDQLRSAISNL 325

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  98 VSNAVEHSPvdsplymdadgQGDHLNIC-----------ITDCGCGFSQEALKHAKERFYMADQSR-----GSelhyGMG 161
Cdd:PRK11006  326 VYNAVNHTP-----------EGTHITVRwqrvpqgaefsVEDNGPGIAPEHIPRLTERFYRVDKARsrqtgGS----GLG 390

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2158165366 162 LYIVDVIIKQHRGELLLSnSAETKGARVTIRLP 194
Cdd:PRK11006  391 LAIVKHALSHHDSRLEIE-SEVGKGTRFSFVLP 422
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 86-194 1.95e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 50.15  E-value: 1.95e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  86 DRVLLERALMNVVSNAVEHSPVDSPLYMDADGQGDHLNICITDCGCGFSQEALKHAKERFYMADQSR-----GSelhyGM 160
Cdd:cd16946     1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRnrasgGS----GL 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2158165366 161 GLYIVDVIIKQHRGELLLSNSaETKGARVTIRLP 194
Cdd:cd16946    77 GLAICHNIALAHGGTISAEHS-PLGGLRLVLTLP 109
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 90-195 2.46e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 49.74  E-value: 2.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  90 LERALMNVVSNAVEHSpvDSPLYMDADGQGDHLNICITDCGCGFSQEALKHAKERFYMADQSRG-SELHYGMGLYIVDVI 168
Cdd:cd16939     1 MARALDNLLRNALRYA--HRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDrATGGFGLGLAIVHRV 78

                          90       100
                  ....*....|....*....|....*..
gi 2158165366 169 IKQHRGELLLSNSaETKGARVTIRLPR 195
Cdd:cd16939    79 ALWHGGHVECDDS-ELGGACFRLTWPR 104
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 83-194 5.64e-07

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 48.96  E-value: 5.64e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  83 ITGDRVLLERALMNVVSNAVEHSPVDSPLYMDADGQGDHLNICITDCGCGFSQEALKHAKERFYMADQSrGSelhyGMGL 162
Cdd:COG5805   389 IYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFFTTKEK-GT----GLGL 463

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2158165366 163 YIVDVIIKQHRGELLLSnSAETKGARVTIRLP 194
Cdd:COG5805   464 MVSYKIIENHNGTIDID-SKVGKGTTFTITLP 494
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 87-195 8.14e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 45.88  E-value: 8.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  87 RVLLERALMNVVSNAVEHSPVDSPLYMDADGQGDHLNICITDCGCGFSQEALKHAKERFYMadqSRGSELHYGMGLYIVD 166
Cdd:cd16943     1 PSQLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFT---TKPVGEGTGLGLSLSY 77

                          90       100
                  ....*....|....*....|....*....
gi 2158165366 167 VIIKQHRGELLLSnSAETKGARVTIRLPR 195
Cdd:cd16943    78 RIIQKHGGTIRVA-SVPGGGTRFTIILPI 105
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 5-194 8.86e-07

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 48.05  E-value: 8.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366   5 TLDEEQKLYLSYAMRSSEQMRRYIKMMIDISRAScGYQLQMEDICfpEFWRHVIS--QAEIICKDkgIVIQ-QTQHALPK 81
Cdd:COG5809   298 TIDEEQKTYLDIMLSELDRIESIISEFLVLAKPQ-AIKYEPKDLN--TLIEEVIPllQPQALLKN--VQIElELEDDIPD 372

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  82 hITGDRVLLERALMNVVSNAVEHSPVDSPLYMDADGQ-GDHLNICITDCGCGFSQEALKHAKERFYmADQSRGSelhyGM 160
Cdd:COG5809   373 -ILGDENQLKQVFINLLKNAIEAMPEGGNITIETKAEdDDKVVISVTDEGCGIPEERLKKLGEPFY-TTKEKGT----GL 446

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2158165366 161 GLYIVDVIIKQHRGELLLSnSAETKGARVTIRLP 194
Cdd:COG5809   447 GLMVSYKIIEEHGGKITVE-SEVGKGTTFSITLP 479
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
100-195 2.18e-06

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 46.93  E-value: 2.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366 100 NAVEHS--PVDSPLYMDADG--QGDHLNICITDCGCGFSQEALKHAKERFYMADQSRgselhyGMGLYIVDVIIKQHRGE 175
Cdd:COG2972   347 NAIEHGiePKEGGGTIRISIrkEGDRLVITVEDNGVGMPEEKLEKLLEELSSKGEGR------GIGLRNVRERLKLYYGE 420

                          90       100
                  ....*....|....*....|..
gi 2158165366 176 --LLLSNSAETKGARVTIRLPR 195
Cdd:COG2972   421 eyGLEIESEPGEGTTVTIRIPL 442
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 90-194 2.36e-06

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 44.79  E-value: 2.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  90 LERALMNVVSNAVEHSPVDSPLYMDAD-GQGDHLNICITDCGCGFSQEALKHAKERFYMADQSRGSELH-YGMGLYIVDV 167
Cdd:cd16925     5 YERVVLNLLSNAFKFTPDGGRIRCILEkFRLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGgTGLGLSIVKE 84

                          90       100
                  ....*....|....*....|....*..
gi 2158165366 168 IIKQHRGELLLSNsAETKGARVTIRLP 194
Cdd:cd16925    85 FVELHGGTVTVSD-APGGGALFQVELP 110
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 90-194 2.65e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 44.24  E-value: 2.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  90 LERALMNVVSNAVEH-SPVDSP-LYMDADGQGDHLNICITDCGCGFSQEalKHAK-----ERFYMADQSRGSelhyGMGL 162
Cdd:cd16921     1 LGQVLTNLLGNAIKFrRPRRPPrIEVGAEDVGEEWTFYVRDNGIGIDPE--YAEKvfgifQRLHSREEYEGT----GVGL 74

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2158165366 163 YIVDVIIKQHRGELLLSnSAETKGARVTIRLP 194
Cdd:cd16921    75 AIVRKIIERHGGRIWLE-SEPGEGTTFYFTLP 105
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
6-194 3.13e-06

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 47.04  E-value: 3.13e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366    6 LDEEQKL-YLSYAMRSSEQMRRYIKMMIDISRASCG-YQLQMEDICFPEFWRHVISQAEIICKDKGIVIQQTQhALPKH- 82
Cdd:PRK09959   742 LSKEQRVeAISLAYATGQSLLGLIGEILDVDKIESGnYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALSCSS-TFPDHy 820

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366   83 -ITGDRVLLERALMNVVSNAVEHS-----PVDSPLyMDADGQGDHLNICITDCGCGFSQEALKHAKERFYMADQSRgSEL 156
Cdd:PRK09959   821 lVKIDPQAFKQVLSNLLSNALKFTtegavKITTSL-GHIDDNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQTSAGR-QQT 898

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 2158165366  157 HYGMGLYIVDVIIKQHRGELLLSnSAETKGARVTIRLP 194
Cdd:PRK09959   899 GSGLGLMICKELIKNMQGDLSLE-SHPGIGTTFTITIP 935
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 80-193 3.48e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 44.43  E-value: 3.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  80 PKHITGDRVLLERALMNVVSNAVEHSPVDSPLYMDADGQGDHLNICITDCGCGFSQEALKHAKERFYMADQSRGSELH-Y 158
Cdd:cd16947    11 PIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQgN 90

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2158165366 159 GMGLYIVDVIIKQHRGELLLSNSAETKGArVTIRL 193
Cdd:cd16947    91 GLGLTITKRLAESMGGSIYVNSKPYEKTV-FTVTL 124
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 96-194 4.47e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 43.82  E-value: 4.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  96 NVVSNAVEHS----PVDSPLYMDADGQGDHLNICITDCGCGFSQEALKHAKERFYmadqSRGSELHYGMGLYIVDVIIKQ 171
Cdd:cd16915     7 NLIDNALDALaatgAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGV----STKGQGERGIGLALVRQSVER 82

                          90       100
                  ....*....|....*....|...
gi 2158165366 172 HRGELLLSNsAETKGARVTIRLP 194
Cdd:cd16915    83 LGGSITVES-EPGGGTTFSIRIP 104
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
69-195 1.13e-05

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 45.05  E-value: 1.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  69 GIVIQQTQHALPKHITGDRVLLERALMNVVSNAVEHspvdsplyMDADGQ-----------------------GDHLNIC 125
Cdd:PRK13837  540 GVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQA--------MDGAGRvdislsraklrapkvlshgvlppGRYVLLR 611

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366 126 ITDCGCGFSQEALKHAKERFYMAdQSRGSelhyGMGLYIVDVIIKQHRGELLLSnSAETKGARVTIRLPR 195
Cdd:PRK13837  612 VSDTGAGIDEAVLPHIFEPFFTT-RAGGT----GLGLATVHGIVSAHAGYIDVQ-STVGRGTRFDVYLPP 675
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 90-194 1.51e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 42.38  E-value: 1.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  90 LERALMNVVSNAVE---HSPVDSP--LYMDADGQGDHLNICITDCGCGFSQEALKHAKERFYMAdQSRGselhYGMGLYI 164
Cdd:cd16920     1 IQQVLINLVRNGIEamsEGGCERRelTIRTSPADDRAVTISVKDTGPGIAEEVAGQLFDPFYTT-KSEG----LGMGLSI 75

                          90       100       110
                  ....*....|....*....|....*....|
gi 2158165366 165 VDVIIKQHRGELLLSnSAETKGARVTIRLP 194
Cdd:cd16920    76 CRSIIEAHGGRLSVE-SPAGGGATFQFTLP 104
PRK10337 PRK10337
sensor protein QseC; Provisional
 69-183 2.16e-05

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 44.25  E-value: 2.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  69 GIVIQQTQHALPKHITGDRVLLERALMNVVSNAVEHSPVDS--PLYMDADGqgdhlnICITDCGCGFSQEALKHAKERFY 146
Cdd:PRK10337  332 GIDVRLTLNAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSvvDVTLNARN------FTVRDNGPGVTPEALARIGERFY 405

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2158165366 147 M---ADQSrGSelhyGMGLYIVDVIIKQHRGELLLSNSAE 183
Cdd:PRK10337  406 RppgQEAT-GS----GLGLSIVRRIAKLHGMNVSFGNAPE 440
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 67-193 4.02e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 41.85  E-value: 4.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  67 DKGIVIqqTQHALPKH-ITGDRVLLERALMNVVSNAVEHSpvDSPLYMDADGQGDHLNICITDCGCGFSQEALKHAKERF 145
Cdd:cd16954    16 RKGVSI--SLDISPELrFPGERNDLMELLGNLLDNACKWC--LEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRG 91

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2158165366 146 YMADQSRGSElhyGMGLYIVDVIIKQHRGELLLSNSAEtKGARVTIRL 193
Cdd:cd16954    92 QRLDEQRPGQ---GLGLAIAKEIVEQYGGELSLSDSPL-GGARFEVVF 135
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
86-165 8.63e-04

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 37.97  E-value: 8.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  86 DRVLLerALMNVVSNAVEHS---PVDSPLYMDADGQGDHLNICITDCGCGFSQEALKHAKerfymaDQSRGSelhyGMGL 162
Cdd:COG2172    33 DDLVL--AVSEAVTNAVRHAyggDPDGPVEVELELDPDGLEIEVRDEGPGFDPEDLPDPY------STLAEG----GRGL 100


                  ...
gi 2158165366 163 YIV 165
Cdd:COG2172   101 FLI 103
PRK15347 PRK15347
two component system sensor kinase;
86-194 1.48e-03

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 38.85  E-value: 1.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  86 DRVLLERALMNVVSNAVEHSPvDSPLYMDADGQGDHLNICITDCGCGFSQEALKHAKERFYMAD-QSRGSelhyGMGLYI 164
Cdd:PRK15347  510 DSLRLRQILVNLLGNAVKFTE-TGGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADtHSQGT----GLGLTI 584

                          90       100       110
                  ....*....|....*....|....*....|
gi 2158165366 165 VDVIIKQHRGELLLsNSAETKGARVTIRLP 194
Cdd:PRK15347  585 ASSLAKMMGGELTL-FSTPGVGSCFSLVLP 613
HATPase_CheA-like cd16916
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ...
 82-194 1.71e-03

Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.


Pssm-ID: 340393 [Multi-domain]  Cd Length: 178  Bit Score: 37.56  E-value: 1.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  82 HITGDRVLLERA--------LMNVVSNAVEHSpVDSP-------------LYMDADGQGDHLNICITDCGCGFSQEALKH 140
Cdd:cd16916    23 VVEGEDTELDKSvlekladpLTHLLRNAVDHG-IEAPeerlaagkppegtITLRAEHQGNQVVIEVSDDGRGIDREKIRE 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366 141 -AKER------------------------FYMADQSrgSELH-YGMGLYIVDVIIKQHRGELLLSnSAETKGARVTIRLP 194
Cdd:cd16916   102 kAIERglitadeaatlsddevlnlifapgFSTAEQV--TDVSgRGVGMDVVKRSIESLGGTIEVE-SEPGQGTTFTIRLP 178
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 78-194 2.02e-03

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 38.35  E-value: 2.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  78 ALPKHITGDRVLLERALMNVVSNAVEHSPVDSpLYMDADGQGDHLNICITDCGCGFSQEALKHAKERFYMADQSRGSElh 157
Cdd:PRK11466  550 DLPTALMGDPRRIRQVITNLLSNALRFTDEGS-IVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKRGGT-- 626

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2158165366 158 yGMGLYIVDVIIKQHRGELLLSNSAEtKGARVTIRLP 194
Cdd:PRK11466  627 -GLGLTISSRLAQAMGGELSATSTPE-VGSCFCLRLP 661
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 82-194 2.22e-03

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 37.96  E-value: 2.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  82 HITGDRVLL--ERA-----LMN-VVSNAVEHSPVDSP---LYMDADGQGDHLNICITDCGCGFSQEAlkhakerfymaDQ 150
Cdd:COG3920   384 ELDGPDVELpaDAAvplglILNeLVTNALKHAFLSGEggrIRVSWRREDGRLRLTVSDNGVGLPEDV-----------DP 452

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2158165366 151 SRGSelhyGMGLYIVDVIIKQHRGELLLSNSaetKGARVTIRLP 194
Cdd:COG3920   453 PARK----GLGLRLIRALVRQLGGTLELDRP---EGTRVRITFP 489
HATPase_EL346-LOV-HK-like cd16951
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 83-194 4.79e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.


Pssm-ID: 340427 [Multi-domain]  Cd Length: 131  Bit Score: 35.86  E-value: 4.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2158165366  83 ITGDRVLL--ERA------LMNVVSNAVEH--SPVDS-PLYMDADGQGDHLNICITDCGCGFSQEALKHAKerfymadqs 151
Cdd:cd16951    25 ITGDTGPVssEVAtaiglvVNELLQNALKHafSDREGgTITIRSVVDGDYLRITVIDDGVGLPQDEDWPNK--------- 95

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2158165366 152 rGSelhygMGLYIVDVIIKQHRGELLLSNSAETkGARVTIRLP 194
Cdd:cd16951    96 -GS-----LGLQIVRSLVEGELKAFLEVQSAEN-GTRVNIDIP 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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