|
Name |
Accession |
Description |
Interval |
E-value |
| PRK07726 |
PRK07726 |
DNA topoisomerase 3; |
1-648 |
0e+00 |
|
DNA topoisomerase 3;
Pssm-ID: 236078 [Multi-domain] Cd Length: 658 Bit Score: 1038.97 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 1 MQLFLCEKPSQAKDIARVLGISKREQGFISSGNIVVTWAVGHLLETASPEAYGEQYGRpWRADVLPVLPEAWKMVVKDQT 80
Cdd:PRK07726 1 MRLFIAEKPSVGRDIADVLKPHKKGDGYIEGNGYIVTWAIGHLLELAEPEAYDERYKR-WRLEDLPIIPEKWKLVVKKKT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 81 KSQFTVISKLLKKASEVVIATDADREGEVIARELLEYCHYSGAVRRLWLSALDEASVKEALGNILPGEKTALLYDAGKGR 160
Cdd:PRK07726 80 AKQFNVVKKLLKQATEIVIATDADREGELIAREILDYCGVRKPIKRLWISSLTDKAIKRAFANLKPGKETIPLYYSALAR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 161 SQADWLIGMNLTRLYTLKARDSGVSEVLSVGRVQTPTLAMVVNRDNEITSFVPKPWWQVHALIeKEGVRFRAGWVPVEQY 240
Cdd:PRK07726 160 SRADWLVGINMTRAYTLLGRKAGYNGVLSVGRVQTPTLALVVRRDEEIENFVPKPYWEVEAHL-TPGERFTAKWQPSEPY 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 241 CDEEKRCINPQAARAVGQLCQQQgRATVLEVTQKREKTAAPLCFDLGTLQQVCSRKFGMGANDVLAIAQALYETHKATTY 320
Cdd:PRK07726 239 QDEEGRLLDRPLAEQVVARIQGQ-PAKVTEVETKRKKEYAPLLYDLSELQIDANKRFGLSAKETLDIAQSLYETHKLITY 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 321 PRTDCGFLPTSMQQEIPDVLAAVAKSDPAVAPVLNQLDRQFVSRVWNDKKITAHHAIIPTRQAFDLSRLSADELKVYHLI 400
Cdd:PRK07726 318 PRTDSRYLPEDMVATLPEVLNAISKVDPYLLLAPPVLDPSIRSRAWNDKKVTAHHAIIPTEQPPNLSKLSEDERKVYDLI 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 401 RQHYFAQFLPLQESDVTEASFNIGGQLFRTRGKVGVVTGWKSLFQAekdddEEDVDGDSMALPALAKGDVCAVTGSEVKD 480
Cdd:PRK07726 398 ARRYLAQFLPPAEYDKTTIELEIAGGTFIAKGKQVVEAGWKALLGK-----KEEDEEKEQPLPVLAKGDELKVEKGEVKE 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 481 MKTSPPKPFTEGTLIAAMKNAASFVSDPKLKKVLRDNAGLGTEATRAAVLETLFKRHYLEKKGKHIHSTQMARELIAALP 560
Cdd:PRK07726 473 GQTQPPKRFTEGTLLSAMENIARFVQDKELKKTLKETDGLGTEATRAGIIEKLFKRGYLEKKGKYIHATDKGKQLIDALP 552
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 561 ETLTSPGMTALWEQALDDISQGKMSLAVFMQKQLQWTRHLVEKGRQDS--VKITAPVTPPCPLCKGPTSKRKGKNGDFWG 638
Cdd:PRK07726 553 EELTSPDMTAKWEQALDQISEGQLSYQDFMQPLKQWLKQLVEQAKQSSekYKFDNLTGPKCPDCGKPMLKVKGKNGKMLV 632
|
650
....*....|
gi 2154551036 639 CIRYPDCEGI 648
Cdd:PRK07726 633 CQDRECGKRK 642
|
|
| topB |
TIGR01056 |
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase ... |
1-652 |
0e+00 |
|
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase III from bacteria and its equivalents encoded on plasmids. The gene is designated topB if found in the bacterial chromosome, traE on conjugative plasmid RP4, etc. These enzymes are involved in the control of DNA topology. DNA topoisomerase III belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273419 [Multi-domain] Cd Length: 660 Bit Score: 795.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 1 MQLFLCEKPSQAKDIARVLGISKREQGFISSGN-IVVTWAVGHLLETASPEAYGEQYGRpWRADVLPVLPEAWKMVVKDQ 79
Cdd:TIGR01056 1 MTLVLCEKPSQARDLATVLAKKKKGNGYLEIGVgGFVTWAVGHLVELAEPEEYDEKYKN-WRTYDLPLEPEDWQLVVSDK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 80 TKSQFTVISKLLK--KASEVVIATDADREGEVIARELLEYCHYSGAVR--RLWLSALDEASVKEALGNILPGEKTALLYD 155
Cdd:TIGR01056 80 TKKQFNVIKRILKenKVDEVVIATDPDREGELIAREILDYLKVTDKVTikRLWISSLVDSSIRKAFKNLRPKSETEGLYK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 156 AGKGRSQADWLIGMNLTRLYTLKARDSGVSEVLSVGRVQTPTLAMVVNRDNEITSFVPKPWWQVHALIEKEGVRFRAGWV 235
Cdd:TIGR01056 160 SGVARARADWLVGINLTRAFTKLGREAGNDGVLSVGRVQTPTLAMVVKRENEIKNFVGKPFYEVSATINKDEQEFTTEWQ 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 236 PveqYCDEEKRCINPQAARAVGQLCQQQGrATVLEVTQKREKTAAPLCFDLGTLQQVCSRKFGMGANDVLAIAQALYETH 315
Cdd:TIGR01056 240 P---YKDEEERELHEFLAENVVTDLTQKP-ALVTDIEKERKKTSAPLFYDLSALQEDANKRFGISAKRTLDIAQKLYETH 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 316 KATTYPRTDCGFLPTSMQQEIPDVLAAVAKSDPAVAPVlNQLDRQFVSRVWNDKKITAHHAIIPTRQAFDLSRLSADELK 395
Cdd:TIGR01056 316 KLITYPRTDSRYLPEDEKEMLLEVLDALKVITPALLPI-KKRDELTNNRLWNDKKIEDHHAIIPTGNDFNLSDLSEEERN 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 396 VYHLIRQHYFAQFLPLQESDVTEASFNIGGQLFRTRGKVGVVTGWKSLFQAEKDDDEEDVDGdsmaLPALAKGDVCAVTG 475
Cdd:TIGR01056 395 VYKLIAQNYLMQFMPKEEYETTTIEIAIGKLMFEAKGKILQDNGWKALLGKQEEDEETEDTT----LPAFQKGDELDVET 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 476 SEVKDMKTSPPKPFTEGTLIAAMKNAASFVSDPKLKKVLRDNAGLGTEATRAAVLETLFKRHYLEKKGKHIHSTQMAREL 555
Cdd:TIGR01056 471 LELLEKQTKPPARYTEGTLLSAMTNPAAFVQDKGLKKTLKETKGLGTEATRADIIENLFKRGFIQKKKNKIYITKNGKLL 550
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 556 IAALPETLTSPGMTALWEQALDDISQGKMSLAVFMQKQLQWTRHLVEKGRQDSVKITAPVTPPCPlCKGPTSKRKGKNGD 635
Cdd:TIGR01056 551 CLLLPELLTKPDLTAQWEQYLNGISAGEKDDDDFINTINEMIKQTINEEKKNPETIQKVAKEPVS-CGGIAKCPAKDNGR 629
|
650
....*....|....*..
gi 2154551036 636 FWGCIRYPDCEGIISTG 652
Cdd:TIGR01056 630 LIDCKKFPECTEYGNGC 646
|
|
| TopA |
COG0550 |
DNA topoisomerase IA [Replication, recombination and repair]; |
1-602 |
5.98e-175 |
|
DNA topoisomerase IA [Replication, recombination and repair];
Pssm-ID: 440316 [Multi-domain] Cd Length: 541 Bit Score: 509.25 E-value: 5.98e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 1 MQLFLCEKPSQAKDIARVLGiskreqgfissGNIVVTWAVGHLLETASPE-AYGEQYgrpwraDVLPvlpeawKMVVKDQ 79
Cdd:COG0550 1 KKLVIVESPAKAKTIAKYLG-----------KDYVVTASVGHLRDLPKPElDVDVEN------DFEP------KYEVIPG 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 80 TKSQFTVISKLLKKASEVVIATDADREGEVIARELLEYCHYSGAVRRLWLSALDEASVKEALGNilPGEKTALLYDAGKG 159
Cdd:COG0550 58 KKKQVKELKKLAKKADEVILATDPDREGEAIAWHLLELLGDKKPVKRVVFNEITKKAIKEAFKN--PRDIDMNLVDAQQA 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 160 RSQADWLIGMNLTRLYTLKARDSgvsevLSVGRVQTPTLAMVVNRDNEITSFVPKPWWQVHALIEKEGVRFRAGWVPVeq 239
Cdd:COG0550 136 RRILDRLVGYNLSPLLWKKVKRG-----LSAGRVQSPALRLIVEREREIEAFVPEEYWTIEATFKTGGGEFTAKLVKI-- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 240 ycdEEKRCINPQAARAVGQLCQQQgRATVLEVTQKREKTAAPLCFDLGTLQQVCSRKFGMGANDVLAIAQALYEThKATT 319
Cdd:COG0550 209 ---DGKKILDEEEAEAILAALKGK-TFTVTSVEKKPKKRNPPPPFTTSTLQQEASRKLGFSAKKTMSIAQRLYEV-GLIT 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 320 YPRTDCGFLPTSMQQEIPDVLAAVAKSDpavapVLNQLDRQFVSrvwNDKKITAHHAIIPTRQAFDLSRLSADELKVYHL 399
Cdd:COG0550 284 YMRTDSVRLSEDAVAAAREYIEALYGKE-----YLPEKPRVYKT---SKNAQEAHEAIRPTGVTRTPESLSGDEFKLYDL 355
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 400 IRQHYFAQFLPLQESDVTEASFNIGGQLFRTRGKVGVVTGWKSLFQaekDDDEEDVDGDSMALPALAKGDVCAVTGSEVK 479
Cdd:COG0550 356 IWKRFLASQMPPAEYETTTVTIEVGGEEFRASGKVIKFPGFLKVYG---EGKDDEEEEEEKRLPPLKEGEKLKLKKIEPE 432
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 480 DMKTSPPKPFTEGTLIAAMKnaasfvsdpklkkvlrdNAGLGTEATRAAVLETLFKRHYLEKKGKHIHSTQMARELIAAL 559
Cdd:COG0550 433 QHFTKPPPRYTEASLVKAME-----------------ELGIGRPSTYASIIETLQDRGYVEREGKRLVPTELGFIVIDLL 495
|
570 580 590 600
....*....|....*....|....*....|....*....|....*.
gi 2154551036 560 PE---TLTSPGMTALWEQALDDISQGKMSLAVFMQKQLQWTRHLVE 602
Cdd:COG0550 496 EEhfpDLVDYEFTAKMEEKLDEIAEGKLDWKDVLEEFYKPFKELVE 541
|
|
| Topoisom_bac |
pfam01131 |
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ... |
153-591 |
9.99e-142 |
|
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.
Pssm-ID: 426069 [Multi-domain] Cd Length: 410 Bit Score: 419.73 E-value: 9.99e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 153 LYDAGKGRSQADWLIGMNLTRLYTLKARDSGVsevLSVGRVQTPTLAMVVNRDNEITSFVPKPWWQVHALIEKEGVRFra 232
Cdd:pfam01131 6 LVDAQLARRELDWLIGFNLSRLLTLKLKGNKL---LSAGRVQTPTLALIVEREREIENFVPEPYWTIEATLKDGGGVF-- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 233 gwvpvEQYCDEEKRCINPQAARAVGQLCQQqGRATVLEVTQKREKTAAPLCFDLGTLQQVCSRKFGMGANDVLAIAQALY 312
Cdd:pfam01131 81 -----ANAKWKRGRIFDKEEAEAILEKLKK-GTAVVTSVESKEKKKPPPLPFNTTTLQKEASRKLGFSAKKTMSIAQKLY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 313 ETHKATTYPRTDCGFLPTSMqqEIPDVLAAVAKSDPAVAPVLNQLDRQF-VSRVWNDKKITAHHAIIPTRQAFDLSRLSA 391
Cdd:pfam01131 155 EKHGLITYPRTDSTYLSDDA--TLKAILEYLTKNYGKYLPYAPRLLKKTkGKLTVGNAKVTAHEAIRPTGDIPVLPELSD 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 392 DELKVYHLIRQHYFAQFLPLQESDVTEASFNIGGQLFRTRGKVGVVTGWKSLFQAEKDDDEEDvdgdsmaLPALAKGDVC 471
Cdd:pfam01131 233 DERKLYELIVRRFLASQMPPAVYETTTVVLEVGGEEFRASGKVILEDGWLKVYPYEKKEDEEE-------LPELKEGEEL 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 472 AVTGSEVKDMKTSPPKPFTEGTLIAAMKnaasfvsdpklkkvlrdNAGLGTEATRAAVLETLFKRHYLEKKGKHIHSTQM 551
Cdd:pfam01131 306 KVTQVEVEEKKTKPPPRYTEASLIKAME-----------------KAGIGTPATRATIIETLLERGYVERKKKSLVPTEL 368
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 2154551036 552 ARELIAALP--ETLTSPGMTALWEQALDDISQGKMSLAVFMQ 591
Cdd:pfam01131 369 GKALVEALEkfPDLVDPELTAELEEKLDEIAEGKLDWKDVLA 410
|
|
| TOP1Ac |
cd00186 |
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ... |
153-601 |
3.65e-101 |
|
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.
Pssm-ID: 238110 [Multi-domain] Cd Length: 381 Bit Score: 314.16 E-value: 3.65e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 153 LYDAGKGRSQADWLIGMNLTRLYTLKARDSGVsevLSVGRVQTPTLAMVVNRDNEITSFVPKPWWQVHAliekegvrfra 232
Cdd:cd00186 3 LVNAQLARRILDRLVGFNLSRLLTKKLRRKGV---LSAGRVQSPTLGLIVEREREIKAFVPEDYWEIKE----------- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 233 gwvpveqycdeekrcinpqaaravgqlcqqqgrATVLEVTQKREKTAAPLCFDLGTLQQVCSRKFGMGANDVLAIAQALY 312
Cdd:cd00186 69 ---------------------------------AVVVSVEKKEKKKNPPPPFTTSTLQQEASSKLGFSAKKTMQIAQKLY 115
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 313 ETHKaTTYPRTDCGFLPTSMQQEIPDVLAAVAKSDPaVAPVLNQLDRQfvsRVWNDKKITAHHAIIPTRQAF---DLSRL 389
Cdd:cd00186 116 EAGL-ITYPRTDSTRLSEEAILEAREYIQAIYGKEY-LYPAPLLGRRN---PKRGKKEQGAHEAIRPTKVAPtpeLEANL 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 390 SADELKVYHLIRQHYFAQFLPLQESDVTEASFNIGGQLFRTRGKVGVVTGWKSLFQaekdddeEDVDGDSMALPALAKGD 469
Cdd:cd00186 191 SEDEFKLYELIWRRFLASQMADAKYEETTVTLEIGGEKFKASGKVLLEDGWLEVYP-------EEKDDEEEEPPPLKEGD 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 470 VCAVTGSEVKDMKTSPPKPFTEGTLIAAMKnaasfvsdpklkkvlrdNAGLGTEATRAAVLETLFKRHYLEKKGKHIHST 549
Cdd:cd00186 264 ELKLEEVELEEKETQPPPRYTEASLIKLME-----------------KRGIGRPSTYASIIETLLDRGYVEKEKKKLIPT 326
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 2154551036 550 QMARELIAALPET---LTSPGMTALWEQALDDISQGKMSLAVFMQKQLQWTRHLV 601
Cdd:cd00186 327 ELGFAVIELLEKHfpeLVDPEFTAKLEEKLDEIAEGKKDYQEVLEEFYEEFKKIV 381
|
|
| TOP1Ac |
smart00437 |
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, ... |
272-555 |
7.86e-63 |
|
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit
Pssm-ID: 214663 [Multi-domain] Cd Length: 259 Bit Score: 209.41 E-value: 7.86e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 272 TQKREKTAAPLCFDLGTLQQVCSRKFGMGANDVLAIAQALYEtHKATTYPRTDCGFLPTSMQQEipdVLAAVAKSDPA-- 349
Cdd:smart00437 1 EEKEKKKNPPPPFTTSTLQQEASRKLGFSAKKTMQIAQKLYE-KGLITYPRTDSTRLSEEAVLE---ARNYIQKLYGKey 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 350 VAPVLNQLDRQFvsRVWNDKKITAHHAIIPTRQAF---DLSRLSADELKVYHLIRQHYFAQFLPLQESDVTEASFNIGGQ 426
Cdd:smart00437 77 LDLAVVLLKPRK--PRKGKKAQGAHEAIRPTKPIFtpeLEKELSEDEFKLYELIWRRFLASQMPDAKYEETKVTIKIGGE 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 427 LFRTRGKVGVVTGWKSLFQAEKDDDEEDvdgdsmaLPALAKGDVCAVTGSEVKDMKTSPPKPFTEGTLIAAMKnaasfvs 506
Cdd:smart00437 155 KFKAKGKTLLFDGWLKVYPEEKKEEEIE-------LPTLKKGDELKVEEVEVEEKETKPPARYTEASLIKLME------- 220
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 2154551036 507 dpklkkvlrdNAGLGTEATRAAVLETLFKRHYLEKKGKHIHSTQMAREL 555
Cdd:smart00437 221 ----------KRGIGRPSTYASIIETLLDRGYVTKKKKKLIPTELGIAV 259
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK07726 |
PRK07726 |
DNA topoisomerase 3; |
1-648 |
0e+00 |
|
DNA topoisomerase 3;
Pssm-ID: 236078 [Multi-domain] Cd Length: 658 Bit Score: 1038.97 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 1 MQLFLCEKPSQAKDIARVLGISKREQGFISSGNIVVTWAVGHLLETASPEAYGEQYGRpWRADVLPVLPEAWKMVVKDQT 80
Cdd:PRK07726 1 MRLFIAEKPSVGRDIADVLKPHKKGDGYIEGNGYIVTWAIGHLLELAEPEAYDERYKR-WRLEDLPIIPEKWKLVVKKKT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 81 KSQFTVISKLLKKASEVVIATDADREGEVIARELLEYCHYSGAVRRLWLSALDEASVKEALGNILPGEKTALLYDAGKGR 160
Cdd:PRK07726 80 AKQFNVVKKLLKQATEIVIATDADREGELIAREILDYCGVRKPIKRLWISSLTDKAIKRAFANLKPGKETIPLYYSALAR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 161 SQADWLIGMNLTRLYTLKARDSGVSEVLSVGRVQTPTLAMVVNRDNEITSFVPKPWWQVHALIeKEGVRFRAGWVPVEQY 240
Cdd:PRK07726 160 SRADWLVGINMTRAYTLLGRKAGYNGVLSVGRVQTPTLALVVRRDEEIENFVPKPYWEVEAHL-TPGERFTAKWQPSEPY 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 241 CDEEKRCINPQAARAVGQLCQQQgRATVLEVTQKREKTAAPLCFDLGTLQQVCSRKFGMGANDVLAIAQALYETHKATTY 320
Cdd:PRK07726 239 QDEEGRLLDRPLAEQVVARIQGQ-PAKVTEVETKRKKEYAPLLYDLSELQIDANKRFGLSAKETLDIAQSLYETHKLITY 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 321 PRTDCGFLPTSMQQEIPDVLAAVAKSDPAVAPVLNQLDRQFVSRVWNDKKITAHHAIIPTRQAFDLSRLSADELKVYHLI 400
Cdd:PRK07726 318 PRTDSRYLPEDMVATLPEVLNAISKVDPYLLLAPPVLDPSIRSRAWNDKKVTAHHAIIPTEQPPNLSKLSEDERKVYDLI 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 401 RQHYFAQFLPLQESDVTEASFNIGGQLFRTRGKVGVVTGWKSLFQAekdddEEDVDGDSMALPALAKGDVCAVTGSEVKD 480
Cdd:PRK07726 398 ARRYLAQFLPPAEYDKTTIELEIAGGTFIAKGKQVVEAGWKALLGK-----KEEDEEKEQPLPVLAKGDELKVEKGEVKE 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 481 MKTSPPKPFTEGTLIAAMKNAASFVSDPKLKKVLRDNAGLGTEATRAAVLETLFKRHYLEKKGKHIHSTQMARELIAALP 560
Cdd:PRK07726 473 GQTQPPKRFTEGTLLSAMENIARFVQDKELKKTLKETDGLGTEATRAGIIEKLFKRGYLEKKGKYIHATDKGKQLIDALP 552
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 561 ETLTSPGMTALWEQALDDISQGKMSLAVFMQKQLQWTRHLVEKGRQDS--VKITAPVTPPCPLCKGPTSKRKGKNGDFWG 638
Cdd:PRK07726 553 EELTSPDMTAKWEQALDQISEGQLSYQDFMQPLKQWLKQLVEQAKQSSekYKFDNLTGPKCPDCGKPMLKVKGKNGKMLV 632
|
650
....*....|
gi 2154551036 639 CIRYPDCEGI 648
Cdd:PRK07726 633 CQDRECGKRK 642
|
|
| topB |
TIGR01056 |
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase ... |
1-652 |
0e+00 |
|
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase III from bacteria and its equivalents encoded on plasmids. The gene is designated topB if found in the bacterial chromosome, traE on conjugative plasmid RP4, etc. These enzymes are involved in the control of DNA topology. DNA topoisomerase III belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273419 [Multi-domain] Cd Length: 660 Bit Score: 795.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 1 MQLFLCEKPSQAKDIARVLGISKREQGFISSGN-IVVTWAVGHLLETASPEAYGEQYGRpWRADVLPVLPEAWKMVVKDQ 79
Cdd:TIGR01056 1 MTLVLCEKPSQARDLATVLAKKKKGNGYLEIGVgGFVTWAVGHLVELAEPEEYDEKYKN-WRTYDLPLEPEDWQLVVSDK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 80 TKSQFTVISKLLK--KASEVVIATDADREGEVIARELLEYCHYSGAVR--RLWLSALDEASVKEALGNILPGEKTALLYD 155
Cdd:TIGR01056 80 TKKQFNVIKRILKenKVDEVVIATDPDREGELIAREILDYLKVTDKVTikRLWISSLVDSSIRKAFKNLRPKSETEGLYK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 156 AGKGRSQADWLIGMNLTRLYTLKARDSGVSEVLSVGRVQTPTLAMVVNRDNEITSFVPKPWWQVHALIEKEGVRFRAGWV 235
Cdd:TIGR01056 160 SGVARARADWLVGINLTRAFTKLGREAGNDGVLSVGRVQTPTLAMVVKRENEIKNFVGKPFYEVSATINKDEQEFTTEWQ 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 236 PveqYCDEEKRCINPQAARAVGQLCQQQGrATVLEVTQKREKTAAPLCFDLGTLQQVCSRKFGMGANDVLAIAQALYETH 315
Cdd:TIGR01056 240 P---YKDEEERELHEFLAENVVTDLTQKP-ALVTDIEKERKKTSAPLFYDLSALQEDANKRFGISAKRTLDIAQKLYETH 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 316 KATTYPRTDCGFLPTSMQQEIPDVLAAVAKSDPAVAPVlNQLDRQFVSRVWNDKKITAHHAIIPTRQAFDLSRLSADELK 395
Cdd:TIGR01056 316 KLITYPRTDSRYLPEDEKEMLLEVLDALKVITPALLPI-KKRDELTNNRLWNDKKIEDHHAIIPTGNDFNLSDLSEEERN 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 396 VYHLIRQHYFAQFLPLQESDVTEASFNIGGQLFRTRGKVGVVTGWKSLFQAEKDDDEEDVDGdsmaLPALAKGDVCAVTG 475
Cdd:TIGR01056 395 VYKLIAQNYLMQFMPKEEYETTTIEIAIGKLMFEAKGKILQDNGWKALLGKQEEDEETEDTT----LPAFQKGDELDVET 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 476 SEVKDMKTSPPKPFTEGTLIAAMKNAASFVSDPKLKKVLRDNAGLGTEATRAAVLETLFKRHYLEKKGKHIHSTQMAREL 555
Cdd:TIGR01056 471 LELLEKQTKPPARYTEGTLLSAMTNPAAFVQDKGLKKTLKETKGLGTEATRADIIENLFKRGFIQKKKNKIYITKNGKLL 550
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 556 IAALPETLTSPGMTALWEQALDDISQGKMSLAVFMQKQLQWTRHLVEKGRQDSVKITAPVTPPCPlCKGPTSKRKGKNGD 635
Cdd:TIGR01056 551 CLLLPELLTKPDLTAQWEQYLNGISAGEKDDDDFINTINEMIKQTINEEKKNPETIQKVAKEPVS-CGGIAKCPAKDNGR 629
|
650
....*....|....*..
gi 2154551036 636 FWGCIRYPDCEGIISTG 652
Cdd:TIGR01056 630 LIDCKKFPECTEYGNGC 646
|
|
| TopA |
COG0550 |
DNA topoisomerase IA [Replication, recombination and repair]; |
1-602 |
5.98e-175 |
|
DNA topoisomerase IA [Replication, recombination and repair];
Pssm-ID: 440316 [Multi-domain] Cd Length: 541 Bit Score: 509.25 E-value: 5.98e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 1 MQLFLCEKPSQAKDIARVLGiskreqgfissGNIVVTWAVGHLLETASPE-AYGEQYgrpwraDVLPvlpeawKMVVKDQ 79
Cdd:COG0550 1 KKLVIVESPAKAKTIAKYLG-----------KDYVVTASVGHLRDLPKPElDVDVEN------DFEP------KYEVIPG 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 80 TKSQFTVISKLLKKASEVVIATDADREGEVIARELLEYCHYSGAVRRLWLSALDEASVKEALGNilPGEKTALLYDAGKG 159
Cdd:COG0550 58 KKKQVKELKKLAKKADEVILATDPDREGEAIAWHLLELLGDKKPVKRVVFNEITKKAIKEAFKN--PRDIDMNLVDAQQA 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 160 RSQADWLIGMNLTRLYTLKARDSgvsevLSVGRVQTPTLAMVVNRDNEITSFVPKPWWQVHALIEKEGVRFRAGWVPVeq 239
Cdd:COG0550 136 RRILDRLVGYNLSPLLWKKVKRG-----LSAGRVQSPALRLIVEREREIEAFVPEEYWTIEATFKTGGGEFTAKLVKI-- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 240 ycdEEKRCINPQAARAVGQLCQQQgRATVLEVTQKREKTAAPLCFDLGTLQQVCSRKFGMGANDVLAIAQALYEThKATT 319
Cdd:COG0550 209 ---DGKKILDEEEAEAILAALKGK-TFTVTSVEKKPKKRNPPPPFTTSTLQQEASRKLGFSAKKTMSIAQRLYEV-GLIT 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 320 YPRTDCGFLPTSMQQEIPDVLAAVAKSDpavapVLNQLDRQFVSrvwNDKKITAHHAIIPTRQAFDLSRLSADELKVYHL 399
Cdd:COG0550 284 YMRTDSVRLSEDAVAAAREYIEALYGKE-----YLPEKPRVYKT---SKNAQEAHEAIRPTGVTRTPESLSGDEFKLYDL 355
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 400 IRQHYFAQFLPLQESDVTEASFNIGGQLFRTRGKVGVVTGWKSLFQaekDDDEEDVDGDSMALPALAKGDVCAVTGSEVK 479
Cdd:COG0550 356 IWKRFLASQMPPAEYETTTVTIEVGGEEFRASGKVIKFPGFLKVYG---EGKDDEEEEEEKRLPPLKEGEKLKLKKIEPE 432
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 480 DMKTSPPKPFTEGTLIAAMKnaasfvsdpklkkvlrdNAGLGTEATRAAVLETLFKRHYLEKKGKHIHSTQMARELIAAL 559
Cdd:COG0550 433 QHFTKPPPRYTEASLVKAME-----------------ELGIGRPSTYASIIETLQDRGYVEREGKRLVPTELGFIVIDLL 495
|
570 580 590 600
....*....|....*....|....*....|....*....|....*.
gi 2154551036 560 PE---TLTSPGMTALWEQALDDISQGKMSLAVFMQKQLQWTRHLVE 602
Cdd:COG0550 496 EEhfpDLVDYEFTAKMEEKLDEIAEGKLDWKDVLEEFYKPFKELVE 541
|
|
| Topoisom_bac |
pfam01131 |
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ... |
153-591 |
9.99e-142 |
|
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.
Pssm-ID: 426069 [Multi-domain] Cd Length: 410 Bit Score: 419.73 E-value: 9.99e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 153 LYDAGKGRSQADWLIGMNLTRLYTLKARDSGVsevLSVGRVQTPTLAMVVNRDNEITSFVPKPWWQVHALIEKEGVRFra 232
Cdd:pfam01131 6 LVDAQLARRELDWLIGFNLSRLLTLKLKGNKL---LSAGRVQTPTLALIVEREREIENFVPEPYWTIEATLKDGGGVF-- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 233 gwvpvEQYCDEEKRCINPQAARAVGQLCQQqGRATVLEVTQKREKTAAPLCFDLGTLQQVCSRKFGMGANDVLAIAQALY 312
Cdd:pfam01131 81 -----ANAKWKRGRIFDKEEAEAILEKLKK-GTAVVTSVESKEKKKPPPLPFNTTTLQKEASRKLGFSAKKTMSIAQKLY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 313 ETHKATTYPRTDCGFLPTSMqqEIPDVLAAVAKSDPAVAPVLNQLDRQF-VSRVWNDKKITAHHAIIPTRQAFDLSRLSA 391
Cdd:pfam01131 155 EKHGLITYPRTDSTYLSDDA--TLKAILEYLTKNYGKYLPYAPRLLKKTkGKLTVGNAKVTAHEAIRPTGDIPVLPELSD 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 392 DELKVYHLIRQHYFAQFLPLQESDVTEASFNIGGQLFRTRGKVGVVTGWKSLFQAEKDDDEEDvdgdsmaLPALAKGDVC 471
Cdd:pfam01131 233 DERKLYELIVRRFLASQMPPAVYETTTVVLEVGGEEFRASGKVILEDGWLKVYPYEKKEDEEE-------LPELKEGEEL 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 472 AVTGSEVKDMKTSPPKPFTEGTLIAAMKnaasfvsdpklkkvlrdNAGLGTEATRAAVLETLFKRHYLEKKGKHIHSTQM 551
Cdd:pfam01131 306 KVTQVEVEEKKTKPPPRYTEASLIKAME-----------------KAGIGTPATRATIIETLLERGYVERKKKSLVPTEL 368
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 2154551036 552 ARELIAALP--ETLTSPGMTALWEQALDDISQGKMSLAVFMQ 591
Cdd:pfam01131 369 GKALVEALEkfPDLVDPELTAELEEKLDEIAEGKLDWKDVLA 410
|
|
| PRK08173 |
PRK08173 |
DNA topoisomerase III; Validated |
2-624 |
2.10e-138 |
|
DNA topoisomerase III; Validated
Pssm-ID: 236172 [Multi-domain] Cd Length: 862 Bit Score: 426.39 E-value: 2.10e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 2 QLFLCEKPSQAKDIARVLGISKREQGFISSGNIVVTWAVGHLLETASPEAYGEQYGRpWRADVLPVLPEAWKMVVKDQTK 81
Cdd:PRK08173 4 ALIIAEKPSVANDIARALGGFTKHDEYFESDEYVLSSAVGHLLEIAAPEEYEVKRGK-WSFAHLPVIPPHFDLNPIAKTE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 82 SQFTVISKLLKK--ASEVVIATDADREGEVIARELLEYCHYSGAVRRLWLSALDEASVKEALGNILPGEKTALLYDAGKG 159
Cdd:PRK08173 83 SRLKVLTKLIKRkdVTRLINACDAGREGELIFRLIAQHAKAKKPVKRLWLQSMTPQAIRDGFANLRSDEDMQPLADAARC 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 160 RSQADWLIGMNLTRLYT-LKARDSGVsEVLSVGRVQTPTLAMVVNRDNEITSFVPKPWWQVHALIEKEGVRFRAGW---- 234
Cdd:PRK08173 163 RSEADWLVGINGTRAMTaFNSKGGGF-FLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVRAEFVAAAGFYEGRWfdpk 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 235 --VPVEQYCDEEKRCINPQAARAVGQLCQQQgRATVLEvTQKREKTAAPLCFDLGTLQQVCSRKFGMGANDVLAIAQALY 312
Cdd:PRK08173 242 fkKDEFDPEKRASRLWSEAAAEAIVAACRGK-PGTVTE-ESKPSTQLSPLLFDLTSLQREANGRFGFSAKNTLGLAQALY 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 313 ETHKATTYPRTDCGFLPTSMQQEIPDVLAAVAKSDPAVAPVLNQLDRQFV---SRVWNDKKITAHHAIIPTRQAfdLSRL 389
Cdd:PRK08173 320 EKHKVLTYPRTDSRALPEDYLGTVKQTLEMLKESNNYLPHAKQILDKGWVkpnKRIFDNSKISDHFAIIPTLQA--PKSL 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 390 SADELKVYHLIRQHYFAQFLPLQESDVTEASFNIGGQLFRTRGKVGVVTGWKSLFQAEKDDDEEDvdgdsmaLPALAKGD 469
Cdd:PRK08173 398 SEPEQKLYDLVVKRFLAVFFPAAEFLVTTRITEVAGHHFKTEGKVLVNPGWLAVYGKEAQGADAN-------LVPVQKGE 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 470 VCAVTGSEVKDMKTSPPKPFTEGTLIAAMKNAASFVSDPKLKKVLRDNaGLGTEATRAAVLETLFKRHYLEKKGKHIHST 549
Cdd:PRK08173 471 KVKTDKIEAVALTTKPPARYNEATLLSAMEGAGKLVEDDELREAMAEK-GLGTPATRAAIIEGLLGEKYLVREGRELIPT 549
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 550 QMARELIAALP----ETLTSPGMTALWEQALDDISQGKMSLAVFMQKQLQWTRHLVEKGRQ-DSVKIT---APVTPPCPL 621
Cdd:PRK08173 550 AKAFQLMTLLRglgvEELTSPELTGEWEYKLSQIERGKLSRDAFMQEIAQMTQQIVKRAKEyDSDTIPgdyATLQTPCPN 629
|
...
gi 2154551036 622 CKG 624
Cdd:PRK08173 630 CGG 632
|
|
| PRK14724 |
PRK14724 |
DNA topoisomerase III; Provisional |
3-639 |
6.82e-112 |
|
DNA topoisomerase III; Provisional
Pssm-ID: 237803 [Multi-domain] Cd Length: 987 Bit Score: 360.04 E-value: 6.82e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 3 LFLCEKPSQAKDIARVL----GISKREQGFISSGNIVVTWAVGHLLETASPEAYGEQYGRpWRADVLPVLPEAWKMVVKD 78
Cdd:PRK14724 4 LVIAEKPSVAQDIVRALtpvaGKFEKHDEHFESDSYVVTSAVGHLVEIQAPEEFDVKRGK-WSFANLPVIPPYFDLKPVD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 79 QTKSQFTVISKLLKK--ASEVVIATDADREGEVIAReLLEycHYSGA--------VRRLWLSALDEASVKEALGNILPGE 148
Cdd:PRK14724 83 KTKTRLNAVVKLAKRkdVTELVNACDAGREGELIFR-LIE--QYAGGakgglgkpVKRLWLQSMTPQAIRDGFDNLRSDA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 149 KTALLYDAGKGRSQADWLIGMNLTRLYT-LKARDSGVSeVLSVGRVQTPTLAMVVNRDNEITSFVPKPWWQVHALIEKE- 226
Cdd:PRK14724 160 QMQGLASAARSRSEADWLVGINGTRAMTaFNSRDGGFF-LTTVGRVQTPTLSLVVEREEKIRKFVSRDYWEIHAGFHAEa 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 227 ----GVRFRAGWVPVEQycDEE---KRCINPQAARAVGQLCQQQGrATVLEvTQKREKTAAPLCFDLGTLQQVCSRKFGM 299
Cdd:PRK14724 239 geylGKWFDPQWKKASD--DPEaraDRVWSEREARAIADAVRGKA-ATVTE-ESKPTTQASPLLFDLTSLQREANGKFGF 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 300 GANDVLAIAQALYETHKATTYPRTDCGFLPTSMQQEIPDVLAAVAKSD-PAVAPVLNQ-LDRQFV---SRVWNDKKITAH 374
Cdd:PRK14724 315 SAKTTLALAQSLYERHKALTYPRTDSRALPEDYLPVAKQTFEMLATSGmRHLAPFAQQaLDGNYVrpsKRIFDNSKVSDH 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 375 HAIIPTRQAfdLSRLSADELKVYHLIRQHYFAQFLPLQESDVTEASFNIGGQLFRTRGKVGVVTGWKSLF--QAEKDDDE 452
Cdd:PRK14724 395 FAIIPTTQA--PSGLSEAEQKLYDLVVRRFMAVFFPSAEYQVTTRISQVVGHSFKTEGKVLVKPGWLAIYgkEAANEVED 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 453 EDVDGDSMALPALAKGDVCAVTGSEVKDMKTSPPKPFTEGTLIAAMKNAASFVSDPKLKKVLRDNaGLGTEATRAAVLET 532
Cdd:PRK14724 473 AKDGDKGQPLVPVKPGEMVRTEFAEAKGLKTKPPARYSEATLLGAMESAGKQIDDDELREAMQEK-GLGTPATRAAIIEG 551
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 533 LFKRHYLEKKGKHIHSTQMARELIAALP----ETLTSPGMTALWEQALDDISQGKMSLAVFMQKQLQWTRHLVEKGRQ-- 606
Cdd:PRK14724 552 LLTEKYMLREGRELIPTAKAFQLMTLLRglgvEELSRAELTGEWEYKLAQMEKGQLSREAFMQQIAAMTEKLVKKAKEyd 631
|
650 660 670 680
....*....|....*....|....*....|....*....|.
gi 2154551036 607 -DSVKIT-APVTPPCPLCKGPTSKR------KGKNGDFWGC 639
Cdd:PRK14724 632 rDTIPGDyATLSTPCPNCGGVVKENyrryacTGANGAGEGC 672
|
|
| TOP1Ac |
cd00186 |
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ... |
153-601 |
3.65e-101 |
|
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.
Pssm-ID: 238110 [Multi-domain] Cd Length: 381 Bit Score: 314.16 E-value: 3.65e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 153 LYDAGKGRSQADWLIGMNLTRLYTLKARDSGVsevLSVGRVQTPTLAMVVNRDNEITSFVPKPWWQVHAliekegvrfra 232
Cdd:cd00186 3 LVNAQLARRILDRLVGFNLSRLLTKKLRRKGV---LSAGRVQSPTLGLIVEREREIKAFVPEDYWEIKE----------- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 233 gwvpveqycdeekrcinpqaaravgqlcqqqgrATVLEVTQKREKTAAPLCFDLGTLQQVCSRKFGMGANDVLAIAQALY 312
Cdd:cd00186 69 ---------------------------------AVVVSVEKKEKKKNPPPPFTTSTLQQEASSKLGFSAKKTMQIAQKLY 115
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 313 ETHKaTTYPRTDCGFLPTSMQQEIPDVLAAVAKSDPaVAPVLNQLDRQfvsRVWNDKKITAHHAIIPTRQAF---DLSRL 389
Cdd:cd00186 116 EAGL-ITYPRTDSTRLSEEAILEAREYIQAIYGKEY-LYPAPLLGRRN---PKRGKKEQGAHEAIRPTKVAPtpeLEANL 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 390 SADELKVYHLIRQHYFAQFLPLQESDVTEASFNIGGQLFRTRGKVGVVTGWKSLFQaekdddeEDVDGDSMALPALAKGD 469
Cdd:cd00186 191 SEDEFKLYELIWRRFLASQMADAKYEETTVTLEIGGEKFKASGKVLLEDGWLEVYP-------EEKDDEEEEPPPLKEGD 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 470 VCAVTGSEVKDMKTSPPKPFTEGTLIAAMKnaasfvsdpklkkvlrdNAGLGTEATRAAVLETLFKRHYLEKKGKHIHST 549
Cdd:cd00186 264 ELKLEEVELEEKETQPPPRYTEASLIKLME-----------------KRGIGRPSTYASIIETLLDRGYVEKEKKKLIPT 326
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 2154551036 550 QMARELIAALPET---LTSPGMTALWEQALDDISQGKMSLAVFMQKQLQWTRHLV 601
Cdd:cd00186 327 ELGFAVIELLEKHfpeLVDPEFTAKLEEKLDEIAEGKKDYQEVLEEFYEEFKKIV 381
|
|
| PRK07219 |
PRK07219 |
DNA topoisomerase I; Validated |
1-646 |
3.65e-98 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235971 [Multi-domain] Cd Length: 822 Bit Score: 319.64 E-value: 3.65e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 1 MQLFLCEKPSQAKDIARVLGI----SKREQG-----FISSG-NIVVTWAVGHLLETASPEAYGEqygrpWRaDVLPV-LP 69
Cdd:PRK07219 1 TELIIAEKNNAARRIADILSGgkakKKRVNGvpyyeFERKGeKWIVIGLSGHIVTVDFPEEYGD-----WR-DVDPAeLI 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 70 EAwkMVVKDQTKSQF-TVISKLLKKASEVVIATDADREGEVIARELLEYCHYSGA--VRRLWLSALDEASVKEALGNilP 146
Cdd:PRK07219 75 DA--DPVKKITKQNYiNALKKLAKDADEIIIATDYDREGELIGKEAYHILREVCQvpVKRARFSSLTKKEIRKAFEN--P 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 147 GEKTALLYDAGKGRSQADWLIGMNLTRLYTLKARDSGVSEVLSVGRVQTPTLAMVVNRDNEITSFVPKPWWQVHALIEKE 226
Cdd:PRK07219 151 DEIDFNLADAGEARQIIDLYWGAALTRFLSLSVRQLGRWDFLSVGRVQTPTLAFIVDREREIRAFDPEDYWKIEALLDKE 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 227 GVRFRAGWVPV---EQYCDEEKrcinpqaARAVGQLCQQQGRATVLEVTQKREKTAAPLCFDLGTLQQVCSRKFGMGAND 303
Cdd:PRK07219 231 AQYFYRDLIGGheaEKFWDEEE-------AEEIYEKLKGAKEATVSSVKKRERTISPPAPFNTTEFLREASKIFGISPKR 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 304 VLAIAQALYEthKA-TTYPRTDCGFLPTSMqqEIPDVLAAVAKSD---PAVAPVLNQLDRQFVSrvwNDKKITAHHAIIP 379
Cdd:PRK07219 304 AMEIAEKLYT--AGyISYPRTDNTVYPDDL--DPKELLKKLSKKKeygPYAESILEQENIKPTE---GKKETTDHPPIHP 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 380 TRqAFDLSRLSADELKVYHLIRQHYFAQFLPLQESDVTEASFNIGGQLFRTRGKVGVVTGWKSLFQAEKDDDEEdvdgds 459
Cdd:PRK07219 377 VD-VPKREELSDDEWKVYELIVRRFLATLADPAEWEYLKVELDVNGEIFKASGSRLVEEGWHEVYPYEKFDEKE------ 449
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 460 maLPALAKGDVCAVTGSEVKDMKTSPPKPFTEGTLIAAMknaasfvsdpklkkvlrDNAGLGTEATRAAVLETLFKRHYL 539
Cdd:PRK07219 450 --LPDLEEGEKLKVNKIEIEAKETQPPKRYTQSSLIKEM-----------------EKRGLGTKATRHDIIEKLYKRGYV 510
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 540 eKKGKHIHSTQMARELIAALPET---LTSPGMTALWEQALDDISQGKMS---------------LAVFMQKQLQWTRHLV 601
Cdd:PRK07219 511 -IEGDPPRPTDLGIAVIEALEKYapeIVSEEMTAQLEADMQAIEDGKKKkedvteesremlkeiLSELKEKRKEIGDHLA 589
|
650 660 670 680
....*....|....*....|....*....|....*....|....*.
gi 2154551036 602 EKGRQDSVKitAPVTPPCPLCKGPTSKRKGKNGD-FWGCIRYPDCE 646
Cdd:PRK07219 590 GSLKAENRS--LKTIGKCPECGGDLIIIRTDKGSrFVGCSGYPDCR 633
|
|
| topA_arch |
TIGR01057 |
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These ... |
5-645 |
3.23e-82 |
|
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These enzymes are involved in the control of DNA topology. DNA topoisomerase I belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273420 [Multi-domain] Cd Length: 618 Bit Score: 272.09 E-value: 3.23e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 5 LCEKPSQAKDIARVLG----ISKREQG------FISSGNIVVTWAVGHLLETASPEAYGEqygrpwradvlPVLPEAWKM 74
Cdd:TIGR01057 1 IAEKPKVAAKIAGALSdgrvLKKSEYGvpywevRRDGKKIIVASAVGHLFGLHPKSRGGY-----------PVFDIEWVP 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 75 VVKDQTKSQFT-----VISKLLKKASEVVIATDADREGEVIARELLEYCHYSGAVRRLWLSALDEASVKEALGNilPGEK 149
Cdd:TIGR01057 70 IFEFDKGKGYVskyikALSKLAKGADEYINACDYDIEGEVIGFKALKYFCGVERAKRMKFSTLTKQDIRRAYAN--PEEI 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 150 TALLYDAGKGRSQADWLIGMNLTRLYTLKARD-SGVSEVLSVGRVQTPTLAMVVNRDNEITSFVPKPWWQVHALIEKEGV 228
Cdd:TIGR01057 148 DYGMVDAGMARHILDWYWGINLSRALMEAIRAaAGRWVILSAGRVQGPTLAFLVEREREINLFVPKPYWVIKATLEKGGG 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 229 RFRA---GWVPVEQycdeekrcinpQAARAVGQLCQQQGRATVLEVTQKREKTAAPLCFDLGTLQQVCSRKFGMGANDVL 305
Cdd:TIGR01057 228 VFDArpeKWKIWSE-----------EEAKSIKEELKKSPWAAVEEVRSERSILKPPPPFDLGTLQREAYRIFGFSPKKTQ 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 306 AIAQALYEtHKATTYPRTDCGFLPTSMQQEipDVLAAVAKSdPAVAPVLNQLDRQFVSR-VWNDKKITAHHAIIPTRQaF 384
Cdd:TIGR01057 297 SIAQELYE-EALISYPRTSSQKLPPSINYR--AILDNLAKG-PLYREAAERLLETGVLKpVEGKKEDPAHPAIHPTGE-I 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 385 DLSRLSADELKVYHLIRQHYFAQFLPLQESDVTEASFNIGGQLFRTRGKVGVVTGWKSLFQaekdddeeDVDGDSMALPA 464
Cdd:TIGR01057 372 PSQELSKDEKKVYDLIVRRFLAAFSEEAIREKSKVLLRIGQEKFRLSGLRVVKLGWLEYYH--------YSKFEEKELPP 443
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 465 LAKGDVCAVTGSEVKDMKTSPPKPFTEGTLIAAMknaasfvsdpklkkvlrDNAGLGTEATRAAVLETLFKRHYLEKKGK 544
Cdd:TIGR01057 444 LDRGDKIKVVRVDVRVKETQPPARYDKASLIREM-----------------ESRGLGTKATRARIIETLYKRGYIEGKKS 506
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 545 hIHSTQMARELIAAL----PEtLTSPGMTALWEQALDDISQGKMSLAVFMQKQLQWTRHLVE--KGRQDSVKI------- 611
Cdd:TIGR01057 507 -IKVTPLGEAVIETLqrycPE-IISEELTRRFESKLEDIMSGRITKDEVIDEAKKRLRKILEefKKRLDDIGIelgkslg 584
|
650 660 670
....*....|....*....|....*....|....
gi 2154551036 612 TAPVTPPCPLCKGPTSKRKGKNGDFWGCIRYPDC 645
Cdd:TIGR01057 585 SVEVVGKCPKCGGKLVSKYAKKGRFVGCSNYPEC 618
|
|
| PRK05776 |
PRK05776 |
DNA topoisomerase I; Provisional |
3-628 |
2.64e-76 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 235602 [Multi-domain] Cd Length: 670 Bit Score: 257.61 E-value: 2.64e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 3 LFLCEKPSQAKDIARVLG---ISKREQG------FISSGNIVVTWAVGHLLETaspeaYGEQYGrpwradvLPVLPEAWK 73
Cdd:PRK05776 4 LVIAEKPKAARKIAEALSekpIRCRIYGvpywivKRDGKKIVVAPAAGHLFGL-----HTKSKG-------FPVFDYEWK 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 74 MVV-----KDQTKSQFTVISKLLKKASEVVIATDADREGEVIARELLEY-CHYSGAvRRLWLSALDEASVKEALGNILPg 147
Cdd:PRK05776 72 PLYeidkgSKYTKKYYELLSSLSKYADEFINACDYDIEGSVIGYLIIKYlGDPKKA-KRMKFSALTKSDIRRAFRNLET- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 148 ektaLLYD---AGKGRSQADWLIGMNLTRLYTLKARD-SGVSEVLSVGRVQTPTLAMVVNRDNEITSFVPKPWWQVHALI 223
Cdd:PRK05776 150 ----LDYEminAGIARHELDWLWGINVSRALMSSVRDaSGKRVILSAGRVQSPTLKYVVEREIERNLFVPLPYFSVSIII 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 224 EKEGVRFRA---GWvPVEqycDEEKrcinpqaARAVGQLCQQQGRATVLEVTQKREKTAAPLCFDLGTLQQVCSRKFGMG 300
Cdd:PRK05776 226 EKNGYEFTLkyeNK-KFE---TKEE-------AKEILEEIKKTGYLKVTKVEVKIEILEPPPPFNLGDLQVEAARIYGFS 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 301 ANDVLAIAQALYEthKA-TTYPRTDCGFLPTSMQ-QEIPDVLAAVAKSDPAVAPVLnQLDRQFVSRVWNDKKITAHHAII 378
Cdd:PRK05776 295 PYKTQSIAEDLYL--DGlISYPRTNSQKLPPTLNiRNILKGLSRSPQYRPLVNLLL-KETKGVLKPVQGPKDDPAHPAIY 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 379 PTRQAfdLSRLSADELKVYHLIRQHYFAQFLPLQESDVTEASFNIGGQL--FRTRGKVGVVTGWKSLFQAEKDDDEEdvd 456
Cdd:PRK05776 372 PTGEP--PKNLSKDEFKLYDLIVRRFLASFAAPAVLSNTIVTLRVPGFPlvFSASGQRIEERGWLKYYPFHKFDEEE--- 446
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 457 gdsmaLPALAKGDVCAVTGSEVKDMKTSPPKPFTEGTLIAAMknaasfvsdpklkkvlrDNAGLGTEATRAAVLETLFKR 536
Cdd:PRK05776 447 -----LPLLKKGERVKIVDVKVRKSYTKPPSRYSKASLLKWM-----------------ESVGIGTEATRARIIETLFKR 504
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 537 HYLEKKGKHIHSTQMARELIAAL----PEtLTSPGMTALWEQALDDISQGKMS-----------LAVFMQKQLqwtRHLV 601
Cdd:PRK05776 505 GYLTSNGKYIEVTPLGFGVAEVLekyfPD-IVSVELTRDFEEKLEMIRTGKATreevieeaketLNKLLEEFK---KNKD 580
|
650 660
....*....|....*....|....*....
gi 2154551036 602 EKGRQDSvKITAPVTPP--CPLCKGPTSK 628
Cdd:PRK05776 581 EIGEELA-KALGLIKPVgkCKICGREAYK 608
|
|
| PRK07220 |
PRK07220 |
DNA topoisomerase I; Validated |
1-645 |
1.23e-72 |
|
DNA topoisomerase I; Validated
Pssm-ID: 180892 [Multi-domain] Cd Length: 740 Bit Score: 249.29 E-value: 1.23e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 1 MQLFLCEKPSQAKDIARVLGISKREQGFISS----------GNIVVTWAVGHLLETASPEAYGEqygrpWRADVLPVLPE 70
Cdd:PRK07220 1 MHLIITEKNIAARRIAQILAPKKPKKTRVSGvdvyryedngDDTVVVGLSGHIVNIDFPKEYNN-----WQKVDARDLID 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 71 AwKMVVKDQTKSQFTVISKLLKKASEVVIATDADREGEVIAREllEYCHYSGA-----VRRLWLSALDEASVKEALGNil 145
Cdd:PRK07220 76 A-EIITTPTQKKIVTALKKLGKEADRVTIATDYDREGELIGVE--ALNIIKKVnpdikFDRVRYSAITKKEIERAFSN-- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 146 PGEKTALLYDAGKGRSQADWLIGMNLTRLYTLKARDSGvSEVLSVGRVQTPTLAMVVNRDNEITSFVPKPWWQVHALIEK 225
Cdd:PRK07220 151 PVEVDFNLADAGHSRQVIDLVWGAALTRYISLAAGRLG-KMFLSVGRVQSPTLALIVDREKEREAFVPTPYWEIYATLEN 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 226 EGVRFRAGWvPVEQYCDEEKrcinpqAARAVGQLCQqqgRATVLEVtQKREKT-AAPLCFDLGTLQQVCSrKFGMGANDV 304
Cdd:PRK07220 230 NGETFVAQH-STRRFWEKEE------ADRVFEKLGK---TAEVTEV-EKGTKTdKPPTPFNTTEFISAAN-SIGFSAANA 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 305 LAIAQALYeTHKATTYPRTDCGFLPTSMqqEIPDVLAAVAKsdpavAPVlnqldRQFVSRVWNDKKI---------TAHH 375
Cdd:PRK07220 298 MRIAESLY-TNGYISYPRTDNTVYPESL--DLREQIEIFAE-----GPF-----GEYAQKLLEKGELvptrgkketTDHP 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 376 AIIPTRQAfDLSRLSADELKVYHLIRQHYFAQFLPLQESDVTEASFNIGGQLFRTRGKVGVVTGWKSLFQAEKDDDEEdv 455
Cdd:PRK07220 365 PIYPASLA-KKSELKEDEWKVYELVVRRFFATFAGPAEWETMKLRFDIGGEEFRANGSRLTEPGWRWYYPYNAPEDRL-- 441
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 456 dgdsmaLPALAKGDVCAVTGSEVKDMKTSPPKPFTEGTLIAAMknaasfvsdpklkkvlrDNAGLGTEATRAAVLETLFK 535
Cdd:PRK07220 442 ------LPELSEGEELKVKKKEMLDKETQPPGRYGQGRLIKLM-----------------EDLGLGTKATRHEIISKLYS 498
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 536 RHYLEkkGKHIHSTQMARELIAALPE---TLTSPGMTALWEQALDDISQGKMSLAVFMQKQLQWTRHL---VEKGRQDSV 609
Cdd:PRK07220 499 RAYIH--GNPIQPTNTAFAVVDALEKyapTITKPDMTSRLEEDMDKIAEGKIKEDAVLEESREMLEQVfdeLDKNREKIR 576
|
650 660 670 680
....*....|....*....|....*....|....*....|...
gi 2154551036 610 KITA------PVTPPCPLCKGPTSKRKGK-NGDFWGCIRYPDC 645
Cdd:PRK07220 577 ESLReglredKIIGKCPLCGSDLMVRRSKrGSRFIGCEGYPEC 619
|
|
| TOP1Ac |
smart00437 |
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, ... |
272-555 |
7.86e-63 |
|
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit
Pssm-ID: 214663 [Multi-domain] Cd Length: 259 Bit Score: 209.41 E-value: 7.86e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 272 TQKREKTAAPLCFDLGTLQQVCSRKFGMGANDVLAIAQALYEtHKATTYPRTDCGFLPTSMQQEipdVLAAVAKSDPA-- 349
Cdd:smart00437 1 EEKEKKKNPPPPFTTSTLQQEASRKLGFSAKKTMQIAQKLYE-KGLITYPRTDSTRLSEEAVLE---ARNYIQKLYGKey 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 350 VAPVLNQLDRQFvsRVWNDKKITAHHAIIPTRQAF---DLSRLSADELKVYHLIRQHYFAQFLPLQESDVTEASFNIGGQ 426
Cdd:smart00437 77 LDLAVVLLKPRK--PRKGKKAQGAHEAIRPTKPIFtpeLEKELSEDEFKLYELIWRRFLASQMPDAKYEETKVTIKIGGE 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 427 LFRTRGKVGVVTGWKSLFQAEKDDDEEDvdgdsmaLPALAKGDVCAVTGSEVKDMKTSPPKPFTEGTLIAAMKnaasfvs 506
Cdd:smart00437 155 KFKAKGKTLLFDGWLKVYPEEKKEEEIE-------LPTLKKGDELKVEEVEVEEKETKPPARYTEASLIKLME------- 220
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 2154551036 507 dpklkkvlrdNAGLGTEATRAAVLETLFKRHYLEKKGKHIHSTQMAREL 555
Cdd:smart00437 221 ----------KRGIGRPSTYASIIETLLDRGYVTKKKKKLIPTELGIAV 259
|
|
| PRK14973 |
PRK14973 |
DNA topoisomerase I; Provisional |
1-645 |
8.05e-62 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 184936 [Multi-domain] Cd Length: 936 Bit Score: 222.03 E-value: 8.05e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 1 MQLFLCEKPSQAKDIARVLG-----ISKREQGF--ISSGNIVVTWAVGHLLETASPEAYGEqygrpWRADVLP--VLPEA 71
Cdd:PRK14973 1 MHLIIAEKNIAANRIAQILAgktkvQVKKDGGVstYSFDDTVVVGLRGHVVEVDFEPGYTN-----WRSEEHTprSLIDA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 72 wKMVVKDQTKSQFTVISKLLKKASEVVIATDADREGEVI---ARELLEYCHYSGAVRRLWLSALDEASVKEALGNilPGE 148
Cdd:PRK14973 76 -DTIKKPTEKKIVGLIQKLAKKADRVTIATDFDTEGELIgkeAYELVRAVNPKVPIDRARFSAITKEEIVTAFAE--PTD 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 149 KTALLYDAGKGRSQADWLIGMNLTRLYTLKARDSGVSeVLSVGRVQTPTLAMVVNRDNEITSFVPKPWWQVHALIEKEGV 228
Cdd:PRK14973 153 LDFALAAAGEARQIIDLIWGASLTRFISLAAHRGGDN-ILSVGRVQSPTLAMIVDREKEIEAFVPEKYWMLSLATEKDGE 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 229 RFRAGWVpveqycdeEKRCINPQAARAVgqlcqQQGRATVLEVTQKREKTA---APLCFDLGTLQQVCSRkFGMGANDVL 305
Cdd:PRK14973 232 GIEARHT--------HGRFTDSAAAEAA-----YDATKEPLVVTEVKEGHKvdrAPTPFDTTTFIVAASR-LGFSAANAM 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 306 AIAQALYeTHKATTYPRTDCGFLPTSMqqEIPDVLAAVAKS--DPAVAPVLNQLdRQFVSRvwNDKKITAHHAIIPTRQA 383
Cdd:PRK14973 298 RIAEDLY-MNGYISYPRTDNTIYPKSL--DLNGVLATLAKGafSKDVAWVKDNR-RPVPTR--GKKSSTDHPPIHPTGVA 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 384 fDLSRLSADELKVYHLIRQHYFAQFLPLQESDVTEASFNIGGQLFRTRGKVGVVTGWKSLFQAEKDDDEEdvdgdsmaLP 463
Cdd:PRK14973 372 -TREELGDDRWKLYELVVRRFLATLSPDAEWATMKVNFDAGGEPYTATGGRLLEAGWRTVYPYSEAKENI--------LP 442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 464 ALAKGDVCAVTGSEVKDMKTSPPKPFTEGTLIAAMknaasfvsdpklkkvlrDNAGLGTEATRAAVLETLFKRHYLEkkG 543
Cdd:PRK14973 443 AFALGEKLPILAVNLEEKETQPPARYSQSRLIQRM-----------------EELGLGTKSTRHEVIGKLVSRKYIE--G 503
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 544 KHIHSTQMARELIAALPE---TLTSPGMTALWEQALDDISQGKMSL-AVFMQKQLQWTR-------HLVEKGrQDSVKIT 612
Cdd:PRK14973 504 NPLRPTLVGRAVTESLEEhagTITEPDMTQTLEEHMQQIKERKRTRdDVVTESRKMLHRafdeleaNEAVIG-RDIMERT 582
|
650 660 670
....*....|....*....|....*....|....*
gi 2154551036 613 AP--VTPPCPLCKGPTSKRKGKNGDFWGCIRYPDC 645
Cdd:PRK14973 583 AEelTIGPCPVCGKDLRIKHIGSSQFIGCSGYPDC 617
|
|
| PRK06599 |
PRK06599 |
DNA topoisomerase I; Validated |
87-645 |
9.25e-50 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235840 [Multi-domain] Cd Length: 675 Bit Score: 184.68 E-value: 9.25e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 87 ISKLLKKASEVVIATDADREGEVIARELLEYCHYSGA----VRRLWLSALDEASVKEALGNilPGEKTALLYDAGKGRSQ 162
Cdd:PRK06599 67 LKKAAKKADAVYLATDPDREGEAIAWHIAEVLKEAKLkdknVKRVVFNEITKKAVQEAIEN--PRDIDMDLVDAQQARRA 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 163 ADWLIGMNLTRLYTLKARDSgvsevLSVGRVQTPTLAMVVNRDNEITSFVPKPWWQVHALIEKE-GVRFRAGWVPV---- 237
Cdd:PRK06599 145 LDYLVGFKLSPLLWKKVRRG-----LSAGRVQSVALRLICEREDEIEAFIPQEYWTIEADLATSnGEPFTAKLVEVngkk 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 238 -EQYC--DEEkrcinpQAARAVGQLcqQQGRATVLEVTQKREKTAAPLCFDLGTLQQVCSRKFGMGANDVLAIAQALYE- 313
Cdd:PRK06599 220 lEKFSitNEE------QAKALVKAL--EGQAYTVDKIEKKERKRNPPPPFITSTLQQEASRKLGFSAKKTMRIAQKLYEg 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 314 ------THKATTYPRTDCGFLPTSMQQEIPDVLaaVAKSDPAVAPvlnQLDRQFVSRVWNDKKitAHHAIIPTrqafDLS 387
Cdd:PRK06599 292 idlgegTVGLITYMRTDSVRLSNEALDEARKYI--TKKYGKEYLP---AKPRVYKKKSKNAQE--AHEAIRPT----SIN 360
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 388 R--------LSADELKVYHLIRQHYFA-QFLPLQESDVT-EASFNIGGQLFRTRGKVGVVTGWKSLFQAEKDDDEEDVDG 457
Cdd:PRK06599 361 RtpeslkpyLTPDQFKLYELIWKRTVAsQMAPAILDQTSvDIASENGKYVFRATGSVILFPGFLKVYGESKDDEEEDDEK 440
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 458 DsmaLPALAKGDVCAVTGSEVKDMKTSPPKPFTEGTLIAAMknaasfvsdpklkkvlrDNAGLGTEATRAAVLETLFKRH 537
Cdd:PRK06599 441 L---LPPLKEGEKLKLDELLPEQHFTEPPPRYSEASLVKKL-----------------EEYGIGRPSTYASIISTLQDRE 500
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 538 YLEKKGKHIHSTQMARE----LIAALPEtLTSPGMTALWEQALDDISQGKMS----LAVFMQKqLQWTRHLVEKGRQDSV 609
Cdd:PRK06599 501 YVELEKKRFIPTDLGRIvndfLVEHFPK-YVDYDFTAGLEDELDEIAEGKKDwkpvLREFWEP-FISNLEKVEEDVRTEK 578
|
570 580 590
....*....|....*....|....*....|....*..
gi 2154551036 610 KITAPVTPPCPLC-KGPTSKRKGKNGDFWGCIRYPDC 645
Cdd:PRK06599 579 VTQEETDETCPKCgGGPLVLKLGKNGKFLGCSGYPEC 615
|
|
| TOPRIM_TopoIA_TopoIII |
cd03362 |
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type ... |
1-143 |
1.58e-49 |
|
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173782 [Multi-domain] Cd Length: 151 Bit Score: 169.72 E-value: 1.58e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 1 MQLFLCEKPSQAKDIARVLGISKR-------EQGFISSGNIVVTWAVGHLLETASPEAYGEQYGRPWRADvlPVLPEAWK 73
Cdd:cd03362 1 MVLIIAEKPSVAKAIAKILGGGSKkkgkgryYEFYGEGGGYVVTWASGHLLELDFPEEYDPWDKVWPLED--PLFPAPFK 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2154551036 74 MVVKDQTKSQFTVISKLLKKASEVVIATDADREGEVIARELLEYCHYSGA--VRRLWLSALDEASVKEALGN 143
Cdd:cd03362 79 LKVDKGKKKQFKVLKKLAKRADEIVIATDADREGELIGREILEYAKCVKRkpVKRAWFSSLTPKAIRRAFKN 150
|
|
| PRK07561 |
PRK07561 |
DNA topoisomerase I subunit omega; Validated |
1-646 |
4.15e-49 |
|
DNA topoisomerase I subunit omega; Validated
Pssm-ID: 236048 [Multi-domain] Cd Length: 859 Bit Score: 184.61 E-value: 4.15e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 1 MQLFLCEKPSQAKDIARVLGiskreQGFI--SSgnivvtwaVGHL--LETASPEAYGEQYGRPWRAdvLPVLPEA-WKM- 74
Cdd:PRK07561 2 KSLVIVESPAKAKTINKYLG-----SDYVvkAS--------VGHIrdLPTSASSVPAKEKGALWAR--MGVDPDHdFEAl 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 75 ---------VVKDqtksqftvISKLLKKASEVVIATDADREGEVIA---RELLEychysG---AVRRLWLSALDEASVKE 139
Cdd:PRK07561 67 yevlpgkekVVSE--------LKKAAKDADELYLATDPDREGEAIAwhlLEVLG-----GddvPVKRVVFNEITKNAIQE 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 140 ALGNilPGEKTALLYDAGKGRSQADWLIGmnltrlYTlkardsgVSEVL--------SVGRVQTPTLAMVVNRDNEITSF 211
Cdd:PRK07561 134 AFEN--PRELDINLVNAQQARRFLDRLVG------YM-------VSPLLwkkiarglSAGRVQSVAVRLIVEREREIEAF 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 212 VPKPWWQVHALIEK-EGVRFRAGWV-----PVEQYC--DEEkrcinpQAARAVGQLcqQQGRATVLEVTQK--REKTAAP 281
Cdd:PRK07561 199 VPEEYWDIHADLTTpRGDAFEARLThldgkKFAPVDllNEA------QAEAAVAAL--EGARYSVASVEDKptTRKPSAP 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 282 lcFDLGTLQQVCSRKFGMGANDVLAIAQALYET-HkaTTYPRTDcgflPTSMQQE-IPDVLAAVAKS--DPAV--APvln 355
Cdd:PRK07561 271 --FTTSTLQQEASRKLGFSVKKTMRIAQRLYEAgY--ITYMRTD----STNLSQEaINAARGYIGDNygKKYLpeKP--- 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 356 qldRQFVSRVWNDKKitAHHAIIPT---RQAFDLSRLSADELKVYHLIRQhyfaQFLPLQ----ESDVTEASFNIGGQLF 428
Cdd:PRK07561 340 ---RQYSSKAKNAQE--AHEAIRPSdvfRTPDQLKGLEGDAQRLYELIWK----RFVASQmapaRYDSTTVTIAAGDAEL 410
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 429 RTRGKVGVVTGWkslFQAEKDDDEEDVDGDSMALPALAKGDVCAVTGSEVKDMKTSPPKPFTEGTLIAAMKnaasfvsdp 508
Cdd:PRK07561 411 RATGRVLRFDGF---LKVYVEGRDDALDDEDRRLPALKVGDALTLEKLDPTQHFTKPPARYSEASLVKELE--------- 478
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 509 KLkkvlrdnaGLGTEATRAAVLETLFKRHYLEKKGKHIHSTQMARELIAALPET---LTSPGMTALWEQALDDISQGKMS 585
Cdd:PRK07561 479 KL--------GIGRPSTYASIISTIQDRGYVRLENRRFYPEKMGRIVTDRLEEFfprLVDYDFTARMEEELDDIANGEAD 550
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2154551036 586 ----LAVFMQKQLQWTRHLVEKGRQDSVKITAPVTPP--CPLCKGPTSKRKGKNGDFWGCIRYPDCE 646
Cdd:PRK07561 551 wkpvLDDFYKDFSQQLEKAEELREEGGMRPNQMVITDrdCPTCGRGMGIRTGKTGVFLGCSGYALKE 617
|
|
| PRK08780 |
PRK08780 |
DNA topoisomerase I; Provisional |
63-636 |
2.01e-47 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 181555 [Multi-domain] Cd Length: 780 Bit Score: 179.19 E-value: 2.01e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 63 DVLP----VLPE---AWKMVVKDQTKSQFTVISKLLKKASEVVIATDADREGEVIARELLEYCHYSGA-----VRRLWLS 130
Cdd:PRK08780 36 DLVPkegaVDPEngfAMRYDLIDKNEKHVEAIAKAAKSADDLYLATDPDREGEAISWHLAEILKERGLlkdkpMQRVVFT 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 131 ALDEASVKEALGNilPGEKTALLYDAGKGRSQADWLIGMNLTRLYTLKardsgVSEVLSVGRVQTPTLAMVVNRDNEITS 210
Cdd:PRK08780 116 EITPRAIKEAMAK--PRDIASDLVDAQQARRALDYLVGFNLSPLLWRK-----IQRGLSAGRVQSPALRMIVEREEEIEA 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 211 FVPKPWWQVHALIEKEGVRFRAGWV-----PVEQY--CDEEkrcinpQAARAVGQLCQ-QQGRATVLEVT--QKREKTAA 280
Cdd:PRK08780 189 FIAREYWSIEADCAHPSQPFNAKLIkldgqKFEQFtiTDGD------TAEAARLRIQQaAQGTLHVTDVEskERKRNPAP 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 281 PlcFDLGTLQQVCSRKFGMGANDVLAIAQALYE--------THKATTYPRTDCGFLPTSMQQEIPDVLAAV--AKSDPAV 350
Cdd:PRK08780 263 P--FTTSTLQQEASRKLGFTTRRTMQVAQKLYEgvdlgdegSVGLITYMRTDSVNLSQDALAEIRDVIARDygTASLPDQ 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 351 ApvlnqldRQFVSRVWNDKKitAHHAIIPT---RQAFDLSR-LSADELKVYHLIRQHYFA-QFLPLQESDVTEASFNIGG 425
Cdd:PRK08780 341 P-------NTYKTKSKNAQE--AHEAVRPTsalRTPAQVARfLSDDQRRLYELIWKRAVAcQMIPATLNTVSVDLAAGSE 411
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 426 QLFRTRGKVGVVTGWKSLFQAEKDDDEEDVDGDSMALPALAKGDVCAVTGSEVKDMKTSPPKPFTEGTLIAAMknaasfv 505
Cdd:PRK08780 412 HVFRATGSTVVVPGFLAVYEEGKDDKSAEDEDEGRKLPPMKEGDNVPLERIRAEQHFTEPPPRYTEASLVKAL------- 484
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 506 sdpklkkvlrDNAGLGTEATRAAVLETLFKRHYLEKKGKHIHSTQMARELIAALPETLT---SPGMTALWEQALDDISQG 582
Cdd:PRK08780 485 ----------EEYGIGRPSTYASIISTLQFRKYVEMEGRRFRPTDVGRAVNKFLTGHFTryvDYDFTARLEDDLDAVSRG 554
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*....
gi 2154551036 583 KMSLAVFMQKQLQWTRHLVEK-----GRQDSVKitAPVTPPCPLCKGPTSKRKGKNGDF 636
Cdd:PRK08780 555 EKEWIPLMEKFWGPFKELVEEkkdsvDRTEAGQ--VRELGTDPKSGKPVSVRIGRFGPM 611
|
|
| TOPRIM_TopoIA |
cd01028 |
TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the ... |
1-143 |
6.33e-43 |
|
TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IA family of DNA topoisomerases (TopoIA). This subgroup contains proteins similar to the Type I DNA topoisomerases: E. coli topisomerases I and III, eukaryotic topoisomerase III and, ATP-dependent reverse gyrase found in archaea and thermophilic bacteria. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA. These enzymes cleave one strand of the DNA duplex, covalently link to the 5' phosphoryl end of the DNA break and allow the other strand of the duplex to pass through the gap. Reverse gyrase is also able to insert positive supercoils in the presence of ATP and negative supercoils in the presence of AMPPNP. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173778 [Multi-domain] Cd Length: 142 Bit Score: 151.22 E-value: 6.33e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 1 MQLFLCEKPSQAKDIARVLG-ISKREQGFISSGNIVVTWAVGHLLETASPEAYGEQygrpWRADVLPVLPEAWKMVVKDQ 79
Cdd:cd01028 1 KVLIIAEKPSKAKTIAKILGkGSKKKGFYGEGGGYVVTASVGHLLELPFPEEYVDW----DKDWPLELFPFEPKYVVIPD 76
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2154551036 80 TKSQFTVISKLLKKASEVVIATDADREGEVIARELLEYCH-YSGAVRRLWLSALDEASVKEALGN 143
Cdd:cd01028 77 KKKQLKALKKLAKKADEIVLATDPDREGELIAWEILEVLKcDNKPVKRAWFSEITPKAIREAFKN 141
|
|
| PRK06319 |
PRK06319 |
DNA topoisomerase I/SWI domain fusion protein; Validated |
3-650 |
7.15e-40 |
|
DNA topoisomerase I/SWI domain fusion protein; Validated
Pssm-ID: 235778 [Multi-domain] Cd Length: 860 Bit Score: 156.91 E-value: 7.15e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 3 LFLCEKPSQAKDIARVLGiskreQGFISSGNIvvtwavGHLLETASPEaygeqYGRPWRADVLP---VLPEAWKmvvkdq 79
Cdd:PRK06319 5 LIIVESPAKIKTLQKLLG-----EGFIFASSL------GHIVDLPAKE-----FGIDIENDFEPdyqILPDKEE------ 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 80 tksqftVISKLLKKASE---VVIATDADREGEVIARELLEYCHYSGAVRRLWLSALDEASVKEALGNilPGEKTALLYDA 156
Cdd:PRK06319 63 ------VINKICKLAKKcdvVYLSPDPDREGEAIAWHIANQLPKNTKIQRISFNAITKGAVTEALKH--PREIDMALVNA 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 157 GKGRSQADWLIGMNLTRLYTLK-ARDSGVSevlsVGRVQTPTLAMVVNRDNEITSFVPKPWWQVHALIE--KEGVRFRAG 233
Cdd:PRK06319 135 QQARRLLDRIVGYKISPILSRKlQRRSGVS----AGRVQSVALKLVVDREKAIEAFVPVEYWNIRVHLKdpKTQKTFWAH 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 234 --------W--VPVEQYCDEEKRCINPQA-ARAVGQLCqQQGRATVLEVTQKREKTAAPLCFDLGTLQQVCSRKFGMGAN 302
Cdd:PRK06319 211 lysvdgkkWekEIPEGKTEDEVLLINSKEkADHIVELL-ESATYTVTRVESKEKRRNAYPPFITSTLQQEASRHFRFSSS 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 303 DVLAIAQALYE-----THKAT---TYPRTDcgflptSMQQEiPDVLAAVAKSdpavapVLNQLDRQFV---SRVWNDKKI 371
Cdd:PRK06319 290 RTMNIAQTLYEgvdldSEGATgliTYMRTD------SVRTD-PEALKQVRKY------IEGTFGKEFLpssPNVYTTKKM 356
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 372 T--AHHAIIPTRQAFD----LSRLSADELKVYHLIRQHYFAQFLPLQESDVTEASFNIG-GQLFRTRGKVGVVTGWKSLF 444
Cdd:PRK06319 357 AqdAHEAIRPTDITLTpeklRSKLTEDQYKLYSLIWKRFVASQMIPAIYDTLAIRITTNkGIDLRATGSLLKFKGFLAVY 436
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 445 QAEKDDDEEDVDGDSmaLPALAKGDVCAVTGSEVKDMKTSPPKPFTEGTLIAamknaasfvsdpKLKKvlrdnAGLGTEA 524
Cdd:PRK06319 437 EEKRDDEGDEEENIH--LPKLHEQDVLTKEELSAEQAFTKPLPRFTEASLVK------------ELEK-----SGIGRPS 497
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 525 TRAAVLETLFKRHYLEKKGKHIHSTQMAReLIAALPET----LTSPGMTALWEQALDDISQGKMSLAVFMQKqlQWTRHL 600
Cdd:PRK06319 498 TYATIMNKIQSREYTLKENQRLRPTELGK-IISQFLETnfprIMDIGFTALMEDELELIADNKKPWKLLLQE--FWELFL 574
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 601 --VEKGRQDS-------------------VKITA----------------------------------PVTPPCPLCKGP 625
Cdd:PRK06319 575 pvVVTAEKEAfiprivteidcpkchkgklVKIWAknryfygcseypecdyktseeeltfnkedyaedtPWDSPCPLCGGE 654
|
730 740
....*....|....*....|....*
gi 2154551036 626 TSKRKGKNGDFWGCIRYPDCEGIIS 650
Cdd:PRK06319 655 MKVRHGRFGTFLGCENYPECRGIIN 679
|
|
| TOP1Bc |
smart00436 |
Bacterial DNA topoisomeraes I ATP-binding domain; Extension of TOPRIM in Bacterial DNA ... |
124-218 |
4.05e-27 |
|
Bacterial DNA topoisomeraes I ATP-binding domain; Extension of TOPRIM in Bacterial DNA topoisomeraes I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase beta subunit
Pssm-ID: 214662 [Multi-domain] Cd Length: 89 Bit Score: 104.97 E-value: 4.05e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 124 VRRLWLSALDEASVKEALGNilPGEKTALLYDAGKGRSQADWLIGMNLTRLYTLKARDSgvseVLSVGRVQTPTLAMVVN 203
Cdd:smart00436 1 IKRIEFSEITKKAIREALKN--PREIDENLVNAQLARRILDRLIGFNLSRLLTKKLRNG----VLSAGRVQTPTLGLIVE 74
|
90
....*....|....*
gi 2154551036 204 RDNEITSFVPKPWWQ 218
Cdd:smart00436 75 REREIKNFVPKPYWE 89
|
|
| PTZ00407 |
PTZ00407 |
DNA topoisomerase IA; Provisional |
87-581 |
1.64e-19 |
|
DNA topoisomerase IA; Provisional
Pssm-ID: 173597 [Multi-domain] Cd Length: 805 Bit Score: 93.08 E-value: 1.64e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 87 ISKLLKKASEVVIATDADREGEVIARELLE-----YCHYSGAVRRLWLSALDEASVKEALGNILPGEKTALLYDAGKGRS 161
Cdd:PTZ00407 118 IEEKADNVTEIILATDPDREGELIAVHALQtikrlYPKLKVPFSRAYMHSITEDGIRKAMRERHVEACDYDLANAAETRH 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 162 QADWLIGMnltrLYTLKARDSGvSEVLSVGRVQTPTLAMVVNRDNEITSFVP--KPWWQVHALIE---KEGVRF------ 230
Cdd:PTZ00407 198 AMDRIFGF----LGSSVVRAAN-SQMRSIGRVQTPALILINEREDKIKAFLEsnKSTFEVQAMCQfpsPHGTTFsqvvti 272
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 231 ---RAGWVPVEQYCDEEKRCINPQAaravgqLCQQQGRATVLEVTQKREKTAAPLCFDLGTLQQVCSRKFGMGANDVLAI 307
Cdd:PTZ00407 273 tpdRKGGASHWATEAEARRCLEQWK------LNNCTGFSVPLEPKPQPSVVPPPQPFTMATAIAKANRQLKYSSEMVSGC 346
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 308 AQALYETHKaTTYPRTDCGFLPTSMqqeIPDVLAAVAK-----------SDPAVAPVLNQLDRQFVSRVWNDKKIT---- 372
Cdd:PTZ00407 347 LQDLFQLGH-ITYPRTDSTRIDESA---LPDIYAAVKKefgkeflyrleDRTVSAQEGKGSKKTGKKRSTKQKKGAdtpv 422
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 373 -----AHHAIIPTR---QAFDLSrLSADELKVYHLIRQHYFAQFLPLQES-----DVTEASFNIGGQLFRTRGKVGVVTG 439
Cdd:PTZ00407 423 gnvedAHEAIRPTNidtTGESLS-LSPPTRAVYDLVRRNTLAVFMIPMKTekivaTVKFTSGSGEKLEFELQGKRVVEPG 501
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 440 WKSLFQAEKDDDEEDVDGDSMALPALAKG----------------DVCAVTGS------------EVKDMKTSPPKPFTE 491
Cdd:PTZ00407 502 WTRAFHKGDKGTTGPAEETDEDITAVEEGapvvpslsqeefkaimNLRSQLGSgvqkgffelrspQVRENRPVPPLPHSE 581
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 492 GTLIAAMKnaasfvsdpklkkvlrdNAGLGTEATRAAVLETLFKRHYLEKKGK-HIHSTQMARELIAALPETLTSP---G 567
Cdd:PTZ00407 582 GTLIEELK-----------------NNGVGRPSTYPMIVKTLLARGYIAVNPKgRCETTPVGRMLVETAKSTFPSIvdiG 644
|
570
....*....|....
gi 2154551036 568 MTALWEQALDDISQ 581
Cdd:PTZ00407 645 FTAAFEKKLDRIAK 658
|
|
| YrdD |
COG0551 |
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination ... |
89-648 |
1.25e-15 |
|
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination and repair];
Pssm-ID: 440317 [Multi-domain] Cd Length: 695 Bit Score: 80.68 E-value: 1.25e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 89 KLLKKASEVVIATDADREGEVIARELLEYCHYSGAVRRLWLSALDEASVKEALGNILPGEKTALLYDAGKGRSQADWLIG 168
Cdd:COG0551 75 KKDKKKKAKALAAALAAADDDAIEAAAAADEEEALKAAEALEAIRKAVVEEVKSRARKRAARAPADVAAAAAAAALARLL 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 169 MNLTRLYTLKARDSGVSEVLSVGRVQTPTLAMVVNRDNEITSFVPKPWWQVHALIEKEGVRFRAGWVPVEQYCDEEKRcI 248
Cdd:COG0551 155 LLAAASRALRLLLLLAAGRLRLLSAVAAGLLELEELLKEFEEEEEEEAAEEEEEEEEAKKKKEEDKKKKKKKKKKDKE-E 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 249 NPQAARAVGQLCQQQGRATVLEVTQKREKTAAPLCFDLGTLQQVCSRKFGMGANDVLAIAQALYETHKATTYPRTDCGFL 328
Cdd:COG0551 234 ETKAIKKKKKAAEAVLAAKKAAKEAKAKKELPTTTTDALPEALATTSLTAAAAASALAAALLEEEGELLYTGGYIRYTRT 313
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 329 PTSMQQEIPDVLAAVAKSDPAVAPVLNQLDRQFVSR--VWNDKKITAHHAIIPTRQAFDLSRLSADELKVYHLIRQHYFA 406
Cdd:COG0551 314 PKSSEADALAALEALKKIAEEPPDERAKKKKKKAKKkkASEAKETTDHPPIPPTTAAALLELLEDRKLLLELLVRRRFAA 393
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 407 QFLPLQESDVTEASFNIGGQLFRTRGKVGVVTGWKSLFQAEKDDDEEdvdgdsmaLPALAKGDVCAVTGSEVKDMKTSPP 486
Cdd:COG0551 394 AADLAKVEELTKVEEADEEELVEAEGGLLEVLGEEEEDDEDEEEELL--------LPPLEEGEPLLLEELLLEKQTTTPP 465
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 487 KPFTEGTLiaamknaasfvsdpKLKKVLRDNAGLGTEATRAAVLETLFKRHYLEKKGKHIHSTQMARELIAALPETLTSP 566
Cdd:COG0551 466 PRYTTELL--------------LKKLEEEGGGGRGTTATIIILILKRRYVVLEEKKTTPTELLVEVVLLLLLPFPKLEDT 531
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 567 GMTALWEQALDDISQGKMSLAVFMQKQLQWTRHLVEKGRQDSVKITAPVTP-----PCPLCKGPTSKRKGKNGDFWGCIR 641
Cdd:COG0551 532 TETAEEEEALLDKEEGKEDKVVEIREEEYPFFKKLLEIAEEEGEEELSEEDevlgeKCPKCGKPLVIKKGRYGKFLGCSN 611
|
....*..
gi 2154551036 642 YPDCEGI 648
Cdd:COG0551 612 YPECKYT 618
|
|
| Toprim |
pfam01751 |
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim ... |
2-132 |
4.76e-15 |
|
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely abolish DnaG type primase activity. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesizes the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases. Type II DNA topoisomerases catalyze the relaxation of DNA supercoiling by causing transient double strand breaks.
Pssm-ID: 396354 [Multi-domain] Cd Length: 93 Bit Score: 70.85 E-value: 4.76e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 2 QLFLCEKPSQAKDIARVLGiskreqgfisSGNIVVTWAVGHLLEtaspeaygeqygrpwradvlpvlpeawkmVVKDQTK 81
Cdd:pfam01751 1 ELIIVEGPSDAIALEKALG----------GGFQAVVAVLGHLLS-----------------------------LEKGPKK 41
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 2154551036 82 SQFTVISKLLKKASEVVIATDADREGEVIARELLEYCHY-SGAVRRLWLSAL 132
Cdd:pfam01751 42 KALKALKELALKAKEVILATDPDREGEAIALKLLELKELlENAGGRVEFSEL 93
|
|
| TOPRIM |
smart00493 |
topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins; |
1-118 |
3.36e-11 |
|
topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins;
Pssm-ID: 214695 [Multi-domain] Cd Length: 75 Bit Score: 59.20 E-value: 3.36e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 1 MQLFLCEKPSQAKDIARVLGiskreqgfissGNIVVTWAVGHLLetaspeaygeqygrpwradvlpvlpeawkmvvkdqT 80
Cdd:smart00493 1 KVLIIVEGPADAIALEKAGG-----------KRGNVVALGGHLL-----------------------------------S 34
|
90 100 110
....*....|....*....|....*....|....*...
gi 2154551036 81 KSQFTVISKLLKKAsEVVIATDADREGEVIARELLEYC 118
Cdd:smart00493 35 KEQIKLLKKLAKKA-EVILATDPDREGEAIAWELAELL 71
|
|
| TOPRIM |
cd00188 |
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type ... |
1-129 |
1.00e-09 |
|
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from bacterial and archaea, and bacterial DNA repair proteins of the RecR/M family. This domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in nucleotide polymerization by primases and in strand joining in topoisomerases and, as a general acid in strand cleavage by topisomerases and nucleases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173773 [Multi-domain] Cd Length: 83 Bit Score: 55.51 E-value: 1.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 1 MQLFLCEKPSQAKDIARVLGiskreqgfissGNIVVTWAVGHLLETaspeaygeqygrpwradvlpvlpeawkmvvkdqt 80
Cdd:cd00188 1 KKLIIVEGPSDALALAQAGG-----------YGGAVVALGGHALNK---------------------------------- 35
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 2154551036 81 ksQFTVISKLLKKASEVVIATDADREGEVIARELLEYC-HYSGAVRRLWL 129
Cdd:cd00188 36 --TRELLKRLLGEAKEVIIATDADREGEAIALRLLELLkSLGKKVRRLLL 83
|
|
| TOPRIM_TopoIA_TopoI |
cd03363 |
TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TOPRIM) domain found in members of the type IA ... |
1-143 |
5.32e-09 |
|
TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TOPRIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173783 [Multi-domain] Cd Length: 123 Bit Score: 54.49 E-value: 5.32e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154551036 1 MQLFLCEKPSQAKDIARVLGiskreqgfissGNIVVTWAVGHLLETASPEAYGEQYGRPWRADVlPVLPEAWKmVVKDqt 80
Cdd:cd03363 1 KKLVIVESPAKAKTIKKYLG-----------KEYEVLASVGHIRDLPKKGLGVDGEDDGFEPKY-VVIPGKKK-VVKE-- 65
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2154551036 81 ksqftvISKLLKKASEVVIATDADREGEVIARELLEYCHYSGAVRRLWLSALDEASVKEALGN 143
Cdd:cd03363 66 ------LKKLAKKADEIYLATDPDREGEAIAWHLAEVLKLKKNVKRVVFNEITKEAIKEALKN 122
|
|
| zf-C4_Topoisom |
pfam01396 |
Topoisomerase DNA binding C4 zinc finger; |
619-646 |
1.45e-06 |
|
Topoisomerase DNA binding C4 zinc finger;
Pssm-ID: 307520 [Multi-domain] Cd Length: 39 Bit Score: 45.33 E-value: 1.45e-06
10 20
....*....|....*....|....*...
gi 2154551036 619 CPLCKGPTSKRKGKNGDFWGCIRYPDCE 646
Cdd:pfam01396 4 CPKCGGDLVLKRGRFGKFVGCSNYPECR 31
|
|
| TOPRIM_RNase_M5_like |
cd01027 |
TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase ... |
80-117 |
1.06e-04 |
|
TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low G+C Gram-positive bacteria. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). The conserved glutamate may act as a general base in nucleotide polymerization by primases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173777 Cd Length: 81 Bit Score: 41.09 E-value: 1.06e-04
10 20 30
....*....|....*....|....*....|....*...
gi 2154551036 80 TKSQFTVISKLLKKASEVVIATDADREGEVIARELLEY 117
Cdd:cd01027 31 SIINKETIELIKKAYRGVIILTDPDRKGEKIRKKLSEY 68
|
|
| PRK04017 |
PRK04017 |
hypothetical protein; Provisional |
80-117 |
8.85e-04 |
|
hypothetical protein; Provisional
Pssm-ID: 179711 Cd Length: 132 Bit Score: 39.94 E-value: 8.85e-04
10 20 30
....*....|....*....|....*....|....*....
gi 2154551036 80 TKSQFTVISKLL-KKASEVVIATDADREGEVIARELLEY 117
Cdd:PRK04017 50 SRTPLAEIAELIaSRGKEVIILTDFDRKGEELAKKLSEY 88
|
|
| |
