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Conserved domains on  [gi|2111034703|ref|WP_225893290|]
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MULTISPECIES: helix-turn-helix transcriptional regulator [Campylobacter]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 709729)

helix-turn-helix (HTH) domain-containing protein with an XRE (Xenobiotic Response Element) family HTH domain, binds DNA and may function as a transcriptional regulator

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|2644244|8831795
SCOP:  4000362

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YiaG super family cl27792
DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];
92-124 1.80e-04

DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];


The actual alignment was detected with superfamily member COG2944:

Pssm-ID: 442187 [Multi-domain]  Cd Length: 64  Bit Score: 37.61  E-value: 1.80e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2111034703  92 VKKVCKELNITQRQLSEMLEIPESTIARWKSGD 124
Cdd:COG2944    11 IRALRERLGLSQAEFAALLGVSVSTVRRWEQGR 43
 
Name Accession Description Interval E-value
YiaG COG2944
DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];
92-124 1.80e-04

DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];


Pssm-ID: 442187 [Multi-domain]  Cd Length: 64  Bit Score: 37.61  E-value: 1.80e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2111034703  92 VKKVCKELNITQRQLSEMLEIPESTIARWKSGD 124
Cdd:COG2944    11 IRALRERLGLSQAEFAALLGVSVSTVRRWEQGR 43
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 90-123 5.14e-04

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 36.38  E-value: 5.14e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2111034703  90 NIVKKVCKELNITQRQLSEMLEIPESTIARWKSG 123
Cdd:cd00093     2 ERLKELRKEKGLTQEELAEKLGVSRSTISRIENG 35
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
92-123 5.95e-04

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 36.34  E-value: 5.95e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2111034703   92 VKKVCKELNITQRQLSEMLEIPESTIARWKSG 123
Cdd:smart00530   2 LKELREEKGLTQEELAEKLGVSRSTLSRIENG 33
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 92-133 2.80e-03

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 34.44  E-value: 2.80e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2111034703  92 VKKVCKELNITQRQLSEMLEIPESTIARWKSGD-LPRLTELFL 133
Cdd:pfam01381   1 LKELREELGLSQEELAEKLGVSRSTISKIENGKrEPSLETLKK 43
 
Name Accession Description Interval E-value
YiaG COG2944
DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];
92-124 1.80e-04

DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];


Pssm-ID: 442187 [Multi-domain]  Cd Length: 64  Bit Score: 37.61  E-value: 1.80e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2111034703  92 VKKVCKELNITQRQLSEMLEIPESTIARWKSGD 124
Cdd:COG2944    11 IRALRERLGLSQAEFAALLGVSVSTVRRWEQGR 43
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
90-132 4.35e-04

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 36.75  E-value: 4.35e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2111034703  90 NIVKKVCKELNITQRQLSEMLEIPESTIARWKSGD-LPRLTELF 132
Cdd:COG1476     7 NRLKELRKERGLTQEELAELLGVSRQTISAIENGKyNPSLELAL 50
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 90-123 5.14e-04

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 36.38  E-value: 5.14e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2111034703  90 NIVKKVCKELNITQRQLSEMLEIPESTIARWKSG 123
Cdd:cd00093     2 ERLKELRKEKGLTQEELAEKLGVSRSTISRIENG 35
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
92-123 5.95e-04

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 36.34  E-value: 5.95e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2111034703   92 VKKVCKELNITQRQLSEMLEIPESTIARWKSG 123
Cdd:smart00530   2 LKELREEKGLTQEELAEKLGVSRSTLSRIENG 33
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
92-124 1.93e-03

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 35.36  E-value: 1.93e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2111034703  92 VKKVCKELNITQRQLSEMLEIPESTIARWKSGD 124
Cdd:COG1396    12 LRELRKARGLTQEELAERLGVSRSTISRIERGR 44
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 92-133 2.80e-03

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 34.44  E-value: 2.80e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2111034703  92 VKKVCKELNITQRQLSEMLEIPESTIARWKSGD-LPRLTELFL 133
Cdd:pfam01381   1 LKELREELGLSQEELAEKLGVSRSTISKIENGKrEPSLETLKK 43
Xre-like-HTH pfam20432
Antitoxin Xre-like helix-turn-helix domain; This entry represents the N-terminal domain of the ...
 92-126 5.32e-03

Antitoxin Xre-like helix-turn-helix domain; This entry represents the N-terminal domain of the antitoxin component Xre of a type II toxin-antitoxin (TA) system, which is the helix-turn-helix (HTH) DNA binding domain, structurally similar to the Cro repressor, therefore, also referred to as HTH/Cro-like DNA-binding domain. This domain is also found in other antitoxin components, associated with a C-terminal toxin-binding domain pfam09722.


Pssm-ID: 466581  Cd Length: 57  Bit Score: 33.69  E-value: 5.32e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2111034703  92 VKKVCKELNITQRQLSEMLEIPESTIARWKSGDLP 126
Cdd:pfam20432   9 VLRLAEALGLTDEELAELLGLSRSTLSRKRKENGR 43
aMBF1 COG1813
Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and ...
 97-125 8.91e-03

Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441418 [Multi-domain]  Cd Length: 70  Bit Score: 33.37  E-value: 8.91e-03
                          10        20
                  ....*....|....*....|....*....
gi 2111034703  97 KELNITQRQLSEMLEIPESTIARWKSGDL 125
Cdd:COG1813    22 EARGLSQEELAEKLGVSESTIRRIERGEA 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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