NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2110869112|ref|WP_225791122|]
View 

CPBP family intramembrane glutamic endopeptidase [Streptococcus pneumoniae]

Protein Classification

CPBP family intramembrane glutamic endopeptidase( domain architecture ID 10494850)

CPBP (CAAX proteases and bacteriocin-processing enzymes) family intramembrane protease similar to Saccharomyces cerevisiae Rce1, a type II CAAX prenyl protease that processes all farnesylated and geranylgeranylated CAAX proteins. It is an integral membrane endoprotease that belongs to the glutamate IMPs, sharing a conserved sequence motif EExxxR

EC:  3.4.-.-
Gene Ontology:  GO:0004222|GO:0016020|GO:0070007|GO:0071586
MEROPS:  G5
PubMed:  24291792

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
YdiL super family cl47285
Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, ...
 8-44 3.38e-03

Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG1266:

Pssm-ID: 440877 [Multi-domain]  Cd Length: 97  Bit Score: 32.46  E-value: 3.38e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 2110869112  8 PISLLYYSLIGFFFALVYRSTDNLRLTILCHSFFNFL 44
Cdd:COG1266   56 LLGFLPAFLLGLVLGLLYLRTGSLWVPILLHALNNLL 92
 
Name Accession Description Interval E-value
YdiL COG1266
Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, ...
 8-44 3.38e-03

Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440877 [Multi-domain]  Cd Length: 97  Bit Score: 32.46  E-value: 3.38e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 2110869112  8 PISLLYYSLIGFFFALVYRSTDNLRLTILCHSFFNFL 44
Cdd:COG1266   56 LLGFLPAFLLGLVLGLLYLRTGSLWVPILLHALNNLL 92
 
Name Accession Description Interval E-value
YdiL COG1266
Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, ...
 8-44 3.38e-03

Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440877 [Multi-domain]  Cd Length: 97  Bit Score: 32.46  E-value: 3.38e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 2110869112  8 PISLLYYSLIGFFFALVYRSTDNLRLTILCHSFFNFL 44
Cdd:COG1266   56 LLGFLPAFLLGLVLGLLYLRTGSLWVPILLHALNNLL 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH