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Conserved domains on  [gi|2103940988|ref|WP_224383373|]
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MULTISPECIES: GNAT family N-acetyltransferase [Burkholderia]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10456837)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  15581578|10940244|9175471|27367672|26818562
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 109-194 3.91e-14

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


:

Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 66.39  E-value: 3.91e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103940988 109 DESTTFLLYTEGHPAGMIGAYFDNTRERRAFVSELWVAHAVRHLRGGVLLLETATGWLAERGARDIYAWIADANRDAIRF 188
Cdd:pfam00583  31 ASEGFFVAEEDGELVGFASLSIIDDEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFLEVAADNLAAIAL 110


                  ....*.
gi 2103940988 189 YERAGF 194
Cdd:pfam00583 111 YEKLGF 116
 
Name Accession Description Interval E-value
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 109-194 3.91e-14

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 66.39  E-value: 3.91e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103940988 109 DESTTFLLYTEGHPAGMIGAYFDNTRERRAFVSELWVAHAVRHLRGGVLLLETATGWLAERGARDIYAWIADANRDAIRF 188
Cdd:pfam00583  31 ASEGFFVAEEDGELVGFASLSIIDDEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFLEVAADNLAAIAL 110


                  ....*.
gi 2103940988 189 YERAGF 194
Cdd:pfam00583 111 YEKLGF 116
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
119-208 1.11e-09

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 55.39  E-value: 1.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103940988 119 EGHPAGMIGAYFDNTRERRAFVSE--LWVAHAVRHlRG-GVLLLETATGWLAERGARDIYAWIADANRDAIRFYERAGFG 195
Cdd:COG1247    60 DGEVVGFASLGPFRPRPAYRGTAEesIYVDPDARG-RGiGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLGFE 138

                          90
                  ....*....|...
gi 2103940988 196 NTGEHAPVARMPG 208
Cdd:COG1247   139 EVGTLPEVGFKFG 151
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 114-177 3.43e-05

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 40.34  E-value: 3.43e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2103940988 114 FLLYTEGHPAGMIGAYFDNTRERRAFVSELWVAHAVRHLRGGVLLLETATGWLAERGARDIYAW 177
Cdd:cd04301     2 LVAEDDGEIVGFASLSPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
 
Name Accession Description Interval E-value
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 109-194 3.91e-14

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 66.39  E-value: 3.91e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103940988 109 DESTTFLLYTEGHPAGMIGAYFDNTRERRAFVSELWVAHAVRHLRGGVLLLETATGWLAERGARDIYAWIADANRDAIRF 188
Cdd:pfam00583  31 ASEGFFVAEEDGELVGFASLSIIDDEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFLEVAADNLAAIAL 110


                  ....*.
gi 2103940988 189 YERAGF 194
Cdd:pfam00583 111 YEKLGF 116
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
119-208 1.11e-09

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 55.39  E-value: 1.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103940988 119 EGHPAGMIGAYFDNTRERRAFVSE--LWVAHAVRHlRG-GVLLLETATGWLAERGARDIYAWIADANRDAIRFYERAGFG 195
Cdd:COG1247    60 DGEVVGFASLGPFRPRPAYRGTAEesIYVDPDARG-RGiGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLGFE 138

                          90
                  ....*....|...
gi 2103940988 196 NTGEHAPVARMPG 208
Cdd:COG1247   139 EVGTLPEVGFKFG 151
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 124-200 1.02e-08

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 50.81  E-value: 1.02e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2103940988 124 GMIGAYFdNTRERRAFVSELWVAHAVRHLRGGVLLLETATGWLAERGARDIYAWIADANRDAIRFYERAGFGNTGEH 200
Cdd:COG0456     1 GFALLGL-VDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIALYEKLGFEEVGER 76
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 114-194 1.62e-07

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 48.90  E-value: 1.62e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103940988 114 FLLYTEGHPAGMIGA-YFDntrERRAFVSELWVAHAVRHLRGGVLLLETATGWLAERGARDIYAWIADANRDAIRFYERA 192
Cdd:COG0454    37 IAVDDKGEPIGFAGLrRLD---DKVLELKRLYVLPEYRGKGIGKALLEALLEWARERGCTALELDTLDGNPAAIRFYERL 113


                  ..
gi 2103940988 193 GF 194
Cdd:COG0454   114 GF 115
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 109-194 1.83e-06

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 44.75  E-value: 1.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103940988 109 DESTTFLLYTEGHPAGMIGAYFDNTRERRAFVSeLWVAHAVRHlRG-GVLLLETAtgwLAERGARDIYAWIADANRDAIR 187
Cdd:pfam13508   1 PGGRFFVAEDDGKIVGFAALLPLDDEGALAELR-LAVHPEYRG-QGiGRALLEAA---EAAAKEGGIKLLELETTNRAAA 75


                  ....*..
gi 2103940988 188 FYERAGF 194
Cdd:pfam13508  76 FYEKLGF 82
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 109-194 5.15e-06

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 44.60  E-value: 5.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103940988 109 DESTTFLLYTE-GHPAGMIGAYFDNtrERRAFVSELWVAHAVRHLRGGVLLLETATGWLAERGARDIYAWiadANRDAIR 187
Cdd:COG1246    25 EEIGEFWVAEEdGEIVGCAALHPLD--EDLAELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLL---TTSAAIH 99


                  ....*..
gi 2103940988 188 FYERAGF 194
Cdd:COG1246   100 FYEKLGF 106
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 114-177 3.43e-05

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 40.34  E-value: 3.43e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2103940988 114 FLLYTEGHPAGMIGAYFDNTRERRAFVSELWVAHAVRHLRGGVLLLETATGWLAERGARDIYAW 177
Cdd:cd04301     2 LVAEDDGEIVGFASLSPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
121-194 4.02e-04

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 37.97  E-value: 4.02e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2103940988 121 HPAGMIGAYFDNtrERRAFVSELWVAHAVRHlRG-GVLLLETATGWLAERGARDIYAWIADANRDAIRFYERAGF 194
Cdd:COG3393     1 ELVAMAGVRAES--PGVAEISGVYTHPEYRG-RGlASALVAALAREALARGARTPFLYVDADNPAARRLYERLGF 72
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 119-194 9.27e-04

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 38.83  E-value: 9.27e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2103940988 119 EGHPAGMIGAYFDNTRERRAFVSeLWVAHAVRHlRG-GVLLLETATGWL-AERGARDIYAWIADANRDAIRFYERAGF 194
Cdd:COG1670    70 DGELIGVVGLYDIDRANRSAEIG-YWLAPAYWG-KGyATEALRALLDYAfEELGLHRVEAEVDPDNTASIRVLEKLGF 145
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
109-200 1.84e-03

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 37.37  E-value: 1.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103940988 109 DESTTFLLYTEGHPAGMIGAYF--DNTRERRAFVSELWVAHAVRHlRG-GVLLLETATGWLAERGARDIYAwiaDANRDA 185
Cdd:COG3153    37 AAGLSLVAEDDGEIVGHVALSPvdIDGEGPALLLGPLAVDPEYRG-QGiGRALMRAALEAARERGARAVVL---LGDPSL 112

                          90
                  ....*....|....*
gi 2103940988 186 IRFYERAGFGNTGEH 200
Cdd:COG3153   113 LPFYERFGFRPAGEL 127
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
109-199 4.59e-03

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 35.93  E-value: 4.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103940988 109 DESTTFLLYTEGHPAGMIGAYFDNTRErrAFVSELWVAHAVRHLRGGVLLLETATGWLAERGARDIYAwiaDANRDAIRF 188
Cdd:COG2153    32 EDARHLLAYDDGELVATARLLPPGDGE--AKIGRVAVLPEYRGQGLGRALMEAAIEEARERGARRIVL---SAQAHAVGF 106

                          90
                  ....*....|.
gi 2103940988 189 YERAGFGNTGE 199
Cdd:COG2153   107 YEKLGFVPVGE 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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