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Conserved domains on  [gi|2103940974|ref|WP_224383359|]
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glycoside hydrolase family 2 protein [Burkholderia vietnamiensis]

Protein Classification

glycoside hydrolase family 2 protein( domain architecture ID 1904426)

glycoside hydrolase family 2 protein belongs to a diverse family that includes beta-galactosidases, beta-glucuronidases, beta-mannosidases, exo-beta-glucosaminidases and, in plants, a mannosyl-glycoprotein endo-beta-mannosidase

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LacZ super family cl43822
Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism];
19-614 1.79e-57

Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism];


The actual alignment was detected with superfamily member COG3250:

Pssm-ID: 442481 [Multi-domain]  Cd Length: 638  Bit Score: 208.08  E-value: 1.79e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103940974  19 AAWIAAPVPGTVAQALAvaGRLD---EAASLDERDHWYRVELR-----GHGARLLRFHGLATLAQAWLDDTPILHSDSMF 90
Cdd:COG3250    21 SGWDPITVPGDWELDLY--GLPDpfvGPWYLYNGVGWYRRTFTvpaswKGKRVFLHFEGVDTAAEVWVNGKKVGYHEGGF 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103940974  91 VTHDVRVT---LAGQHTLFVCFRAlaphlrtaraarrarwrtrLAEPATLRTVRtsllghmpgWFPhhvPTGPWRPVDvL 167
Cdd:COG3250    99 TPFEFDITdylKPGENVLAVRVDN-------------------PSDGSYLEGQD---------WWR---TSGIYRDVW-L 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103940974 168 DPADGTVPAHCNLHARVDGDTGWLDAELTFAAPLPDAFAARLSC----------GEHHATLERAGADRLLATVAVPNVRL 237
Cdd:COG3250   147 EATPKVHIEDVFVTPDLDDGSATLTVEVELENESDAGVTVEVTLldadgkvvatATAKVTLAAGEENTVTLTLTVPNPKL 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103940974 238 WWPHThgePVLYDIALHVGAERIVLGA----TGFRTIEQHagddgNGFGLRVNGTPVFARGACWSSAAPLALHA-DDATY 312
Cdd:COG3250   227 WSPED---PNLYTLVVTLKDDGKVVDTvstrFGFRTIEID-----GDGGFLLNGKPVFLKGVNRHEDWPDDGRAvTDEAM 298

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103940974 313 ARLLGLARDAGFNMIRVGGTmtYEADAFHAWCDRLGLMVWQDFMFANFDYALDDRAFADAVDAEADQFLARRRASPSLAV 392
Cdd:COG3250   299 RRDLELMKEAGFNAVRTSHY--PEDPEFYDLCDELGLLVWDEAPFEWHGMLGDDPEFLEAVEAELREMVRRDRNHPSIIL 376

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103940974 393 LCGGSEIAQQAAMSGLgpkqraveltaerlaaraaawrpdvpyvsdspdggvlpfvprervshyygvGAYLRPLDDARRa 472
Cdd:COG3250   377 WSGGNESGGGPNFAAL---------------------------------------------------YEWVKELDPTRP- 404

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103940974 473 dVRFASEclaFAnvpcdatlerigrphpheprwkAAVPRDPGASWDFddvrdhylrtlydvaperlrREDPARYFELSra 552
Cdd:COG3250   405 -VRFLSE---YG----------------------HAMPNSLGGGYHQ--------------------PSDFEEYQALQ-- 436

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2103940974 553 viadVMRETFSEWRRSgSRCAGALVWQFQDVMP--------GAGWGLLDAAH-LPKSGWYALRQVLQPVQI 614
Cdd:COG3250   437 ----ALEEYWEAFRRR-PRLAGGFIWQLNDYWPeprdndgnFCSWGLVDYYDrTPKPAYYEVKSAWQPVLV 502
Ig_mannosidase super family cl38983
Ig-fold domain; This Ig-like fold domain is found in mannosidase enzymes.
 726-799 2.67e-05

Ig-fold domain; This Ig-like fold domain is found in mannosidase enzymes.


The actual alignment was detected with superfamily member pfam17753:

Pssm-ID: 476840  Cd Length: 78  Bit Score: 43.01  E-value: 2.67e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2103940974 726 DPGIEARVSRAGDAWHVDIDTRHVARHVQIDAPG----FMplDDWFHLAPGATARVALIPQPIGTprIDDAPPSVNIR 799
Cdd:pfam17753   1 DPEITATVTETDGGFEITLTADALALFVWLELAGvdgrFS--DNYFDLLPGEPKTVTFTPGEDTT--LEELKKSLTVR 74
 
Name Accession Description Interval E-value
LacZ COG3250
Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism];
19-614 1.79e-57

Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism];


Pssm-ID: 442481 [Multi-domain]  Cd Length: 638  Bit Score: 208.08  E-value: 1.79e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103940974  19 AAWIAAPVPGTVAQALAvaGRLD---EAASLDERDHWYRVELR-----GHGARLLRFHGLATLAQAWLDDTPILHSDSMF 90
Cdd:COG3250    21 SGWDPITVPGDWELDLY--GLPDpfvGPWYLYNGVGWYRRTFTvpaswKGKRVFLHFEGVDTAAEVWVNGKKVGYHEGGF 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103940974  91 VTHDVRVT---LAGQHTLFVCFRAlaphlrtaraarrarwrtrLAEPATLRTVRtsllghmpgWFPhhvPTGPWRPVDvL 167
Cdd:COG3250    99 TPFEFDITdylKPGENVLAVRVDN-------------------PSDGSYLEGQD---------WWR---TSGIYRDVW-L 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103940974 168 DPADGTVPAHCNLHARVDGDTGWLDAELTFAAPLPDAFAARLSC----------GEHHATLERAGADRLLATVAVPNVRL 237
Cdd:COG3250   147 EATPKVHIEDVFVTPDLDDGSATLTVEVELENESDAGVTVEVTLldadgkvvatATAKVTLAAGEENTVTLTLTVPNPKL 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103940974 238 WWPHThgePVLYDIALHVGAERIVLGA----TGFRTIEQHagddgNGFGLRVNGTPVFARGACWSSAAPLALHA-DDATY 312
Cdd:COG3250   227 WSPED---PNLYTLVVTLKDDGKVVDTvstrFGFRTIEID-----GDGGFLLNGKPVFLKGVNRHEDWPDDGRAvTDEAM 298

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103940974 313 ARLLGLARDAGFNMIRVGGTmtYEADAFHAWCDRLGLMVWQDFMFANFDYALDDRAFADAVDAEADQFLARRRASPSLAV 392
Cdd:COG3250   299 RRDLELMKEAGFNAVRTSHY--PEDPEFYDLCDELGLLVWDEAPFEWHGMLGDDPEFLEAVEAELREMVRRDRNHPSIIL 376

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103940974 393 LCGGSEIAQQAAMSGLgpkqraveltaerlaaraaawrpdvpyvsdspdggvlpfvprervshyygvGAYLRPLDDARRa 472
Cdd:COG3250   377 WSGGNESGGGPNFAAL---------------------------------------------------YEWVKELDPTRP- 404

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103940974 473 dVRFASEclaFAnvpcdatlerigrphpheprwkAAVPRDPGASWDFddvrdhylrtlydvaperlrREDPARYFELSra 552
Cdd:COG3250   405 -VRFLSE---YG----------------------HAMPNSLGGGYHQ--------------------PSDFEEYQALQ-- 436

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2103940974 553 viadVMRETFSEWRRSgSRCAGALVWQFQDVMP--------GAGWGLLDAAH-LPKSGWYALRQVLQPVQI 614
Cdd:COG3250   437 ----ALEEYWEAFRRR-PRLAGGFIWQLNDYWPeprdndgnFCSWGLVDYYDrTPKPAYYEVKSAWQPVLV 502
Ig_mannosidase pfam17753
Ig-fold domain; This Ig-like fold domain is found in mannosidase enzymes.
 726-799 2.67e-05

Ig-fold domain; This Ig-like fold domain is found in mannosidase enzymes.


Pssm-ID: 465483  Cd Length: 78  Bit Score: 43.01  E-value: 2.67e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2103940974 726 DPGIEARVSRAGDAWHVDIDTRHVARHVQIDAPG----FMplDDWFHLAPGATARVALIPQPIGTprIDDAPPSVNIR 799
Cdd:pfam17753   1 DPEITATVTETDGGFEITLTADALALFVWLELAGvdgrFS--DNYFDLLPGEPKTVTFTPGEDTT--LEELKKSLTVR 74
 
Name Accession Description Interval E-value
LacZ COG3250
Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism];
19-614 1.79e-57

Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism];


Pssm-ID: 442481 [Multi-domain]  Cd Length: 638  Bit Score: 208.08  E-value: 1.79e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103940974  19 AAWIAAPVPGTVAQALAvaGRLD---EAASLDERDHWYRVELR-----GHGARLLRFHGLATLAQAWLDDTPILHSDSMF 90
Cdd:COG3250    21 SGWDPITVPGDWELDLY--GLPDpfvGPWYLYNGVGWYRRTFTvpaswKGKRVFLHFEGVDTAAEVWVNGKKVGYHEGGF 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103940974  91 VTHDVRVT---LAGQHTLFVCFRAlaphlrtaraarrarwrtrLAEPATLRTVRtsllghmpgWFPhhvPTGPWRPVDvL 167
Cdd:COG3250    99 TPFEFDITdylKPGENVLAVRVDN-------------------PSDGSYLEGQD---------WWR---TSGIYRDVW-L 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103940974 168 DPADGTVPAHCNLHARVDGDTGWLDAELTFAAPLPDAFAARLSC----------GEHHATLERAGADRLLATVAVPNVRL 237
Cdd:COG3250   147 EATPKVHIEDVFVTPDLDDGSATLTVEVELENESDAGVTVEVTLldadgkvvatATAKVTLAAGEENTVTLTLTVPNPKL 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103940974 238 WWPHThgePVLYDIALHVGAERIVLGA----TGFRTIEQHagddgNGFGLRVNGTPVFARGACWSSAAPLALHA-DDATY 312
Cdd:COG3250   227 WSPED---PNLYTLVVTLKDDGKVVDTvstrFGFRTIEID-----GDGGFLLNGKPVFLKGVNRHEDWPDDGRAvTDEAM 298

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103940974 313 ARLLGLARDAGFNMIRVGGTmtYEADAFHAWCDRLGLMVWQDFMFANFDYALDDRAFADAVDAEADQFLARRRASPSLAV 392
Cdd:COG3250   299 RRDLELMKEAGFNAVRTSHY--PEDPEFYDLCDELGLLVWDEAPFEWHGMLGDDPEFLEAVEAELREMVRRDRNHPSIIL 376

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103940974 393 LCGGSEIAQQAAMSGLgpkqraveltaerlaaraaawrpdvpyvsdspdggvlpfvprervshyygvGAYLRPLDDARRa 472
Cdd:COG3250   377 WSGGNESGGGPNFAAL---------------------------------------------------YEWVKELDPTRP- 404

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2103940974 473 dVRFASEclaFAnvpcdatlerigrphpheprwkAAVPRDPGASWDFddvrdhylrtlydvaperlrREDPARYFELSra 552
Cdd:COG3250   405 -VRFLSE---YG----------------------HAMPNSLGGGYHQ--------------------PSDFEEYQALQ-- 436

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2103940974 553 viadVMRETFSEWRRSgSRCAGALVWQFQDVMP--------GAGWGLLDAAH-LPKSGWYALRQVLQPVQI 614
Cdd:COG3250   437 ----ALEEYWEAFRRR-PRLAGGFIWQLNDYWPeprdndgnFCSWGLVDYYDrTPKPAYYEVKSAWQPVLV 502
Ig_mannosidase pfam17753
Ig-fold domain; This Ig-like fold domain is found in mannosidase enzymes.
 726-799 2.67e-05

Ig-fold domain; This Ig-like fold domain is found in mannosidase enzymes.


Pssm-ID: 465483  Cd Length: 78  Bit Score: 43.01  E-value: 2.67e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2103940974 726 DPGIEARVSRAGDAWHVDIDTRHVARHVQIDAPG----FMplDDWFHLAPGATARVALIPQPIGTprIDDAPPSVNIR 799
Cdd:pfam17753   1 DPEITATVTETDGGFEITLTADALALFVWLELAGvdgrFS--DNYFDLLPGEPKTVTFTPGEDTT--LEELKKSLTVR 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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