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Conserved domains on  [gi|2102955459|ref|WP_224019380|]
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hypothetical protein [Burkholderia vietnamiensis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PqqC super family cl44232
Pyrroloquinoline quinone (PQQ) biosynthesis protein C [Coenzyme transport and metabolism];
99-293 1.10e-09

Pyrroloquinoline quinone (PQQ) biosynthesis protein C [Coenzyme transport and metabolism];


The actual alignment was detected with superfamily member COG5424:

Pssm-ID: 444176  Cd Length: 228  Bit Score: 57.60  E-value: 1.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102955459  99 ATSGAQLYRDIRRIaerTAARSA-RSAFLRALVEQRATRRQLIGYALEYYWIVRAAPGLIGPALGWAASPAERTLL---- 173
Cdd:COG5424     1 LLSPEEFEARLRAE---IARRYLlKHPFLQRLREGKLTREQLRAFALQRYHYVKHFPRYLAAILSRCPDEELRRALlenl 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102955459 174 --QDFLKSELGHDRFLEASLKAVGLAEAQIEQHQPLPAT-FSLAAALGVHARQHPLSFKASLFLFERAQPAFidafdARC 250
Cdd:COG5424    78 yeEDGEGPEEGHIELWLRFAEALGLDREEVDARPPLPETrAAVDAYVNFCRRRSLLEAVAASLTAEGFAPEI-----SRE 152

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2102955459 251 VALGMPEAF-------YRPLRAHADLNDtyRHEDISRQLMaLDTAIDPEA 293
Cdd:COG5424   153 RLEGLLEHYglpdeeaLEYFRLHAELDP--RHAEEALELV-LRLADTPED 199
Poly_export super family cl40153
Polysaccharide biosynthesis/export protein; This is a family of periplasmic proteins involved ...
 50-84 2.55e-03

Polysaccharide biosynthesis/export protein; This is a family of periplasmic proteins involved in polysaccharide biosynthesis and/or export.


The actual alignment was detected with superfamily member pfam02563:

Pssm-ID: 426836 [Multi-domain]  Cd Length: 74  Bit Score: 36.01  E-value: 2.55e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2102955459  50 LIGDLHAGGMTPEELAArspRIADKIPPLLADFNV 84
Cdd:pfam02563  41 LIGPVKVAGLTVEELEA---LIAERLAKYLRDPQV 72
 
Name Accession Description Interval E-value
PqqC COG5424
Pyrroloquinoline quinone (PQQ) biosynthesis protein C [Coenzyme transport and metabolism];
99-293 1.10e-09

Pyrroloquinoline quinone (PQQ) biosynthesis protein C [Coenzyme transport and metabolism];


Pssm-ID: 444176  Cd Length: 228  Bit Score: 57.60  E-value: 1.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102955459  99 ATSGAQLYRDIRRIaerTAARSA-RSAFLRALVEQRATRRQLIGYALEYYWIVRAAPGLIGPALGWAASPAERTLL---- 173
Cdd:COG5424     1 LLSPEEFEARLRAE---IARRYLlKHPFLQRLREGKLTREQLRAFALQRYHYVKHFPRYLAAILSRCPDEELRRALlenl 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102955459 174 --QDFLKSELGHDRFLEASLKAVGLAEAQIEQHQPLPAT-FSLAAALGVHARQHPLSFKASLFLFERAQPAFidafdARC 250
Cdd:COG5424    78 yeEDGEGPEEGHIELWLRFAEALGLDREEVDARPPLPETrAAVDAYVNFCRRRSLLEAVAASLTAEGFAPEI-----SRE 152

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2102955459 251 VALGMPEAF-------YRPLRAHADLNDtyRHEDISRQLMaLDTAIDPEA 293
Cdd:COG5424   153 RLEGLLEHYglpdeeaLEYFRLHAELDP--RHAEEALELV-LRLADTPED 199
Poly_export pfam02563
Polysaccharide biosynthesis/export protein; This is a family of periplasmic proteins involved ...
 50-84 2.55e-03

Polysaccharide biosynthesis/export protein; This is a family of periplasmic proteins involved in polysaccharide biosynthesis and/or export.


Pssm-ID: 426836 [Multi-domain]  Cd Length: 74  Bit Score: 36.01  E-value: 2.55e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2102955459  50 LIGDLHAGGMTPEELAArspRIADKIPPLLADFNV 84
Cdd:pfam02563  41 LIGPVKVAGLTVEELEA---LIAERLAKYLRDPQV 72
TenA_PqqC cd19370
TenA_like proteins, including PqqC and CADD; This family contains proteins with similarity to ...
 125-215 2.62e-03

TenA_like proteins, including PqqC and CADD; This family contains proteins with similarity to TenA, and includes bacterial coenzyme pyrroloquinoline quinone (PQQ) synthesis protein C or PQQC proteins. PQQ is the prosthetic group of several bacterial enzymes, including methanol dehydrogenase of methylotrophs and the glucose dehydrogenase of a number of bacteria. PQQC catalyzes the last step of PQQ biogenesis which involves a ring closure and an eight-electron oxidation of the substrate [3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic acid (AHQQ)]. The exact molecular function of members of this family is unclear. Also belonging to this family is Chlamydia protein CADD (Chlamydia protein Associating with Death Domains), a redox protein toxin unique to Chlamydia species, which modulates host cell apoptosis; its redox activity and death domain binding ability may be required for this biological activity. CADD may have a role in folate metabolism.


Pssm-ID: 381705  Cd Length: 219  Bit Score: 38.73  E-value: 2.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102955459 125 FLRALVEQRATRRQLIGYALEYYWIVRAAPgLIGPALGWAASPAE--RTLLQDFLKSELGHDR--FLEASLK---AVGLA 197
Cdd:cd19370    21 FHVAMHNGTLTKEQLQGYVANRYYYQKTIP-KKLSAIMARCDDAQtrRKWLQNILDEDGGHGEpgHIELWLRlgeALGLT 99

                          90
                  ....*....|....*....
gi 2102955459 198 EAQIEQHQPLPAT-FSLAA 215
Cdd:cd19370   100 RELLSERHPLPATrFAVDT 118
Wza COG1596
Periplasmic protein Wza involved in polysaccharide export, contains SLBB domain of the ...
 50-114 5.03e-03

Periplasmic protein Wza involved in polysaccharide export, contains SLBB domain of the beta-grasp fold [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441204 [Multi-domain]  Cd Length: 182  Bit Score: 37.57  E-value: 5.03e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2102955459  50 LIGDLHAGGMTPEELAArspRIADKIPPLLADFNVLRLLIESDPRRA----AVATSGAQLYRDIRRIAE 114
Cdd:COG1596    54 LIGPVKVAGLTLEELEE---EIEERLAKYLKDPQVTVSVAEYRSRRVyvlgEVNRPGRYPLSSGLTLLD 119
 
Name Accession Description Interval E-value
PqqC COG5424
Pyrroloquinoline quinone (PQQ) biosynthesis protein C [Coenzyme transport and metabolism];
99-293 1.10e-09

Pyrroloquinoline quinone (PQQ) biosynthesis protein C [Coenzyme transport and metabolism];


Pssm-ID: 444176  Cd Length: 228  Bit Score: 57.60  E-value: 1.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102955459  99 ATSGAQLYRDIRRIaerTAARSA-RSAFLRALVEQRATRRQLIGYALEYYWIVRAAPGLIGPALGWAASPAERTLL---- 173
Cdd:COG5424     1 LLSPEEFEARLRAE---IARRYLlKHPFLQRLREGKLTREQLRAFALQRYHYVKHFPRYLAAILSRCPDEELRRALlenl 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102955459 174 --QDFLKSELGHDRFLEASLKAVGLAEAQIEQHQPLPAT-FSLAAALGVHARQHPLSFKASLFLFERAQPAFidafdARC 250
Cdd:COG5424    78 yeEDGEGPEEGHIELWLRFAEALGLDREEVDARPPLPETrAAVDAYVNFCRRRSLLEAVAASLTAEGFAPEI-----SRE 152

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2102955459 251 VALGMPEAF-------YRPLRAHADLNDtyRHEDISRQLMaLDTAIDPEA 293
Cdd:COG5424   153 RLEGLLEHYglpdeeaLEYFRLHAELDP--RHAEEALELV-LRLADTPED 199
Poly_export pfam02563
Polysaccharide biosynthesis/export protein; This is a family of periplasmic proteins involved ...
 50-84 2.55e-03

Polysaccharide biosynthesis/export protein; This is a family of periplasmic proteins involved in polysaccharide biosynthesis and/or export.


Pssm-ID: 426836 [Multi-domain]  Cd Length: 74  Bit Score: 36.01  E-value: 2.55e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2102955459  50 LIGDLHAGGMTPEELAArspRIADKIPPLLADFNV 84
Cdd:pfam02563  41 LIGPVKVAGLTVEELEA---LIAERLAKYLRDPQV 72
TenA_PqqC cd19370
TenA_like proteins, including PqqC and CADD; This family contains proteins with similarity to ...
 125-215 2.62e-03

TenA_like proteins, including PqqC and CADD; This family contains proteins with similarity to TenA, and includes bacterial coenzyme pyrroloquinoline quinone (PQQ) synthesis protein C or PQQC proteins. PQQ is the prosthetic group of several bacterial enzymes, including methanol dehydrogenase of methylotrophs and the glucose dehydrogenase of a number of bacteria. PQQC catalyzes the last step of PQQ biogenesis which involves a ring closure and an eight-electron oxidation of the substrate [3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic acid (AHQQ)]. The exact molecular function of members of this family is unclear. Also belonging to this family is Chlamydia protein CADD (Chlamydia protein Associating with Death Domains), a redox protein toxin unique to Chlamydia species, which modulates host cell apoptosis; its redox activity and death domain binding ability may be required for this biological activity. CADD may have a role in folate metabolism.


Pssm-ID: 381705  Cd Length: 219  Bit Score: 38.73  E-value: 2.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2102955459 125 FLRALVEQRATRRQLIGYALEYYWIVRAAPgLIGPALGWAASPAE--RTLLQDFLKSELGHDR--FLEASLK---AVGLA 197
Cdd:cd19370    21 FHVAMHNGTLTKEQLQGYVANRYYYQKTIP-KKLSAIMARCDDAQtrRKWLQNILDEDGGHGEpgHIELWLRlgeALGLT 99

                          90
                  ....*....|....*....
gi 2102955459 198 EAQIEQHQPLPAT-FSLAA 215
Cdd:cd19370   100 RELLSERHPLPATrFAVDT 118
Wza COG1596
Periplasmic protein Wza involved in polysaccharide export, contains SLBB domain of the ...
 50-114 5.03e-03

Periplasmic protein Wza involved in polysaccharide export, contains SLBB domain of the beta-grasp fold [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441204 [Multi-domain]  Cd Length: 182  Bit Score: 37.57  E-value: 5.03e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2102955459  50 LIGDLHAGGMTPEELAArspRIADKIPPLLADFNVLRLLIESDPRRA----AVATSGAQLYRDIRRIAE 114
Cdd:COG1596    54 LIGPVKVAGLTLEELEE---EIEERLAKYLKDPQVTVSVAEYRSRRVyvlgEVNRPGRYPLSSGLTLLD 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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