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Conserved domains on  [gi|2099743708|ref|WP_223293341|]
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MULTISPECIES: IS1-like element IS1B family transposase [Enterobacteriaceae]

Protein Classification

IS1-like element transposase( domain architecture ID 1750064)

IS1-like element transposase acting on a specific type of insertion sequences (IS), the simplest class of procaryotic transposable elements which are capable of integrating into numerous sites within genomes via a transposition pathway independent of homologous re combination.

Gene Ontology:  GO:0006313

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
transpos_IS1 super family cl41321
IS1 family transposase; Proteins of this family are DDE transposases encoded by the IS1 family ...
8-207 1.25e-100

IS1 family transposase; Proteins of this family are DDE transposases encoded by the IS1 family elements usually through a translational frameshift mechanism.


The actual alignment was detected with superfamily member NF033558:

Pssm-ID: 468085 [Multi-domain]  Cd Length: 199  Bit Score: 290.33  E-value: 1.25e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099743708   8 CPSCsATDGVVRNGKSTAGHQRYLCSHCRKTWQLQFTYTASQPGTHQKIIDMAMNGVGCRATARIMGVGLNTIFRHFKKL 87
Cdd:NF033558    1 CPRC-QSDNVVKNGKSVRGKQRYRCKDCGRQFQLDYEYRGYSEGTKEKILQLYLNGMGFRAIARVLGVSHNTVLRWLKKL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099743708  88 RPQSVTSRIQPGSDVIVCAEMDEQWGYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIWMTDG 167
Cdd:NF033558   80 GPRQVTPEPLKPADIVLICELDELWTFVGNKKNKRWLWYAYDRKTKRILAYVFGDRSAETFRKLWALLKPFKIGFYCTDH 159
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2099743708 168 WPLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRK 207
Cdd:NF033558  160 WKVYAEFLPDEKHLVSKGETQRIERENLTLRHRLARLVRK 199
 
Name Accession Description Interval E-value
transpos_IS1 NF033558
IS1 family transposase; Proteins of this family are DDE transposases encoded by the IS1 family ...
8-207 1.25e-100

IS1 family transposase; Proteins of this family are DDE transposases encoded by the IS1 family elements usually through a translational frameshift mechanism.


Pssm-ID: 468085 [Multi-domain]  Cd Length: 199  Bit Score: 290.33  E-value: 1.25e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099743708   8 CPSCsATDGVVRNGKSTAGHQRYLCSHCRKTWQLQFTYTASQPGTHQKIIDMAMNGVGCRATARIMGVGLNTIFRHFKKL 87
Cdd:NF033558    1 CPRC-QSDNVVKNGKSVRGKQRYRCKDCGRQFQLDYEYRGYSEGTKEKILQLYLNGMGFRAIARVLGVSHNTVLRWLKKL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099743708  88 RPQSVTSRIQPGSDVIVCAEMDEQWGYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIWMTDG 167
Cdd:NF033558   80 GPRQVTPEPLKPADIVLICELDELWTFVGNKKNKRWLWYAYDRKTKRILAYVFGDRSAETFRKLWALLKPFKIGFYCTDH 159
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2099743708 168 WPLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRK 207
Cdd:NF033558  160 WKVYAEFLPDEKHLVSKGETQRIERENLTLRHRLARLVRK 199
DDE_Tnp_IS1 pfam03400
IS1 transposase; Transposase proteins are necessary for efficient DNA transposition. This ...
102-232 7.51e-87

IS1 transposase; Transposase proteins are necessary for efficient DNA transposition. This family represents bacterial IS1 transposases.


Pssm-ID: 281403  Cd Length: 131  Bit Score: 252.97  E-value: 7.51e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099743708 102 VIVCAEMDEQWGYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIWMTDGWPLYESRLKGKLHV 181
Cdd:pfam03400   1 AIICAELDEQWGFVGAKARQHWLFYAYDRKRGGVLAHTFGERTDATCGELLALLSPFDIGILMSDDWGLYERELKGDKHL 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2099743708 182 ISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVEQHDKVIGHYLNIKHYQ 232
Cdd:pfam03400  81 IGKIFTQRIERHNLNLRQHIARLARKSICFSKSVEIHDKVIGHFIEIHHFQ 131
InsB COG1662
Transposase and inactivated derivatives, IS1 family [Mobilome: prophages, transposons];
47-232 4.10e-62

Transposase and inactivated derivatives, IS1 family [Mobilome: prophages, transposons];


Pssm-ID: 441268 [Multi-domain]  Cd Length: 193  Bit Score: 192.61  E-value: 4.10e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099743708  47 ASQPGTHQKIIDMAMNGVGCRATARIMGVGLNTIFRHFKKLRPQSVTSRIQPGSDVIVCAEMDEQWGYVGAKSRQRWLFY 126
Cdd:COG1662     5 AISEELKILIDRVEIELIGLALLARGVGLSISALIITVNTKLVAVYVQLKVPNLSDKRLVEVDELWTFVGSKKNKVWIWY 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099743708 127 AYDRLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIWMTDGWPLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGR 206
Cdd:COG1662    85 AVDRDTGRIVAFVVGDRDKKTARKLWEKLKPFEIAVIYTDGWKAYASLIPEKRHVVSKGYTNHIERNNLTLRHRLKRLVR 164
                         170       180
                  ....*....|....*....|....*.
gi 2099743708 207 KSLSFSKSVEQHDKVIGHYLNIKHYQ 232
Cdd:COG1662   165 KTICFSKSLEMHDKAIKLFFHYYNFG 190
transpos_ISL3 NF033550
ISL3 family transposase;
7-82 6.81e-03

ISL3 family transposase;


Pssm-ID: 468079 [Multi-domain]  Cd Length: 369  Bit Score: 37.18  E-value: 6.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099743708   7 SCPSC-SATDGVVRNGKSTAGH--------------QRYLCSHCRKTWQLQFT-------YTAsqpGTHQKIIDMAMNGV 64
Cdd:NF033550   12 TCPECgKPSRRVHDTGKRRIRHlpifgrpvylelrvRRFKCPECGKTFTEELPwarkrsrITL---RLEAAVLALLLELM 88
                          90
                  ....*....|....*...
gi 2099743708  65 GCRATARIMGVGLNTIFR 82
Cdd:NF033550   89 SVAAVARQLGVSWSTVWR 106
 
Name Accession Description Interval E-value
transpos_IS1 NF033558
IS1 family transposase; Proteins of this family are DDE transposases encoded by the IS1 family ...
8-207 1.25e-100

IS1 family transposase; Proteins of this family are DDE transposases encoded by the IS1 family elements usually through a translational frameshift mechanism.


Pssm-ID: 468085 [Multi-domain]  Cd Length: 199  Bit Score: 290.33  E-value: 1.25e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099743708   8 CPSCsATDGVVRNGKSTAGHQRYLCSHCRKTWQLQFTYTASQPGTHQKIIDMAMNGVGCRATARIMGVGLNTIFRHFKKL 87
Cdd:NF033558    1 CPRC-QSDNVVKNGKSVRGKQRYRCKDCGRQFQLDYEYRGYSEGTKEKILQLYLNGMGFRAIARVLGVSHNTVLRWLKKL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099743708  88 RPQSVTSRIQPGSDVIVCAEMDEQWGYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIWMTDG 167
Cdd:NF033558   80 GPRQVTPEPLKPADIVLICELDELWTFVGNKKNKRWLWYAYDRKTKRILAYVFGDRSAETFRKLWALLKPFKIGFYCTDH 159
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2099743708 168 WPLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRK 207
Cdd:NF033558  160 WKVYAEFLPDEKHLVSKGETQRIERENLTLRHRLARLVRK 199
DDE_Tnp_IS1 pfam03400
IS1 transposase; Transposase proteins are necessary for efficient DNA transposition. This ...
102-232 7.51e-87

IS1 transposase; Transposase proteins are necessary for efficient DNA transposition. This family represents bacterial IS1 transposases.


Pssm-ID: 281403  Cd Length: 131  Bit Score: 252.97  E-value: 7.51e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099743708 102 VIVCAEMDEQWGYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIWMTDGWPLYESRLKGKLHV 181
Cdd:pfam03400   1 AIICAELDEQWGFVGAKARQHWLFYAYDRKRGGVLAHTFGERTDATCGELLALLSPFDIGILMSDDWGLYERELKGDKHL 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2099743708 182 ISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVEQHDKVIGHYLNIKHYQ 232
Cdd:pfam03400  81 IGKIFTQRIERHNLNLRQHIARLARKSICFSKSVEIHDKVIGHFIEIHHFQ 131
InsB COG1662
Transposase and inactivated derivatives, IS1 family [Mobilome: prophages, transposons];
47-232 4.10e-62

Transposase and inactivated derivatives, IS1 family [Mobilome: prophages, transposons];


Pssm-ID: 441268 [Multi-domain]  Cd Length: 193  Bit Score: 192.61  E-value: 4.10e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099743708  47 ASQPGTHQKIIDMAMNGVGCRATARIMGVGLNTIFRHFKKLRPQSVTSRIQPGSDVIVCAEMDEQWGYVGAKSRQRWLFY 126
Cdd:COG1662     5 AISEELKILIDRVEIELIGLALLARGVGLSISALIITVNTKLVAVYVQLKVPNLSDKRLVEVDELWTFVGSKKNKVWIWY 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099743708 127 AYDRLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIWMTDGWPLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGR 206
Cdd:COG1662    85 AVDRDTGRIVAFVVGDRDKKTARKLWEKLKPFEIAVIYTDGWKAYASLIPEKRHVVSKGYTNHIERNNLTLRHRLKRLVR 164
                         170       180
                  ....*....|....*....|....*.
gi 2099743708 207 KSLSFSKSVEQHDKVIGHYLNIKHYQ 232
Cdd:COG1662   165 KTICFSKSLEMHDKAIKLFFHYYNFG 190
InsA COG3677
Transposase InsA [Mobilome: prophages, transposons];
1-232 2.29e-29

Transposase InsA [Mobilome: prophages, transposons];


Pssm-ID: 442893 [Multi-domain]  Cd Length: 241  Bit Score: 109.96  E-value: 2.29e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099743708   1 MASVSISCPSCSATDgVVRNGKSTAGHQRYLCSHCRKTWQLQFTY--TASQPGTHQKIIDMAMNGVGCRATARIMGVGLN 78
Cdd:COG3677    12 RWPNGPVCPHCGSTR-IVKNGKTRNGRQRYRCKDCGRTFTVTTGTifEGSKLPLWLQAIRLLLNGISLRQIARVLGVSYK 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099743708  79 TIFRHFKKLRpQSVTSRIQPGSDVIVCAEMDEQWGYVGAKSRQRWLFYAYDRLRKTVVAHVFGERTMATLGRLMSLLSPF 158
Cdd:COG3677    91 TVWRWLHRIR-EALDELVDEVDEGEGLVGEEDEKTKSKRRRKRGKKLVKGLKKGVVVKVRARGARKSKLAVRLELADLLL 169
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2099743708 159 DVViwmtDGWPLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVEQHDKVIGHYLNIKHYQ 232
Cdd:COG3677   170 RRI----ILAALVAPLATDLAVGVDSKKHELLELARHTRRRRYRRLVRKAERFSKKSRNRILASWTVRHHYVYV 239
HTH_Tnp_IS1 pfam12759
InsA C-terminal domain; This short domain is found at the C-terminus of the InsA protein. This ...
43-88 8.15e-22

InsA C-terminal domain; This short domain is found at the C-terminus of the InsA protein. This domain contains a helix-turn-helix domain.


Pssm-ID: 289525 [Multi-domain]  Cd Length: 46  Bit Score: 84.59  E-value: 8.15e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2099743708  43 FTYTASQPGTHQKIIDMAMNGVGCRATARIMGVGLNTIFRHFKKLR 88
Cdd:pfam12759   1 YTYEARKPGTKEKIIEMAMNGAGCRATARTLKVGINTVIRTLKNSR 46
Zn_Tnp_IS1 pfam03811
InsA N-terminal domain; This appears to be a short zinc binding domain found in IS1 InsA ...
1-36 1.81e-12

InsA N-terminal domain; This appears to be a short zinc binding domain found in IS1 InsA family protein. It is found at the N-terminus of the protein and may be a DNA-binding domain.


Pssm-ID: 281762 [Multi-domain]  Cd Length: 35  Bit Score: 59.91  E-value: 1.81e-12
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2099743708   1 MASVSISCPSCSATDgVVRNGKSTAGHQRYLCSHCR 36
Cdd:pfam03811   1 MASVSIHCPRCSSTD-VYRHGKSTAGHQRFRCRHCR 35
transpos_ISL3 NF033550
ISL3 family transposase;
7-82 6.81e-03

ISL3 family transposase;


Pssm-ID: 468079 [Multi-domain]  Cd Length: 369  Bit Score: 37.18  E-value: 6.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099743708   7 SCPSC-SATDGVVRNGKSTAGH--------------QRYLCSHCRKTWQLQFT-------YTAsqpGTHQKIIDMAMNGV 64
Cdd:NF033550   12 TCPECgKPSRRVHDTGKRRIRHlpifgrpvylelrvRRFKCPECGKTFTEELPwarkrsrITL---RLEAAVLALLLELM 88
                          90
                  ....*....|....*...
gi 2099743708  65 GCRATARIMGVGLNTIFR 82
Cdd:NF033550   89 SVAAVARQLGVSWSTVWR 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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