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Conserved domains on  [gi|2054967001|ref|WP_216243485|]
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bifunctional 2-polyprenyl-6-hydroxyphenol methylase/3-demethylubiquinol 3-O-methyltransferase UbiG [Polynucleobacter sp. Fuers-14]

Protein Classification

bifunctional 2-polyprenyl-6-hydroxyphenol methylase/3-demethylubiquinol 3-O-methyltransferase UbiG( domain architecture ID 11493423)

bifunctional 2-polyprenyl-6-hydroxyphenol methylase/3-demethylubiquinol 3-O-methyltransferase UbiG is a class I SAM-dependent methyltransferase that catalyzes both methylation steps in ubiquinone biosynthesis

CATH:  3.40.50.150
EC:  2.1.1.222|2.1.1.64
Gene Ontology:  GO:0102208|GO:0008425|GO:0032259|GO:0006744
PubMed:  10419476|11583838

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiG TIGR01983
ubiquinone biosynthesis O-methyltransferase; This model represents an O-methyltransferase ...
 7-224 1.43e-121

ubiquinone biosynthesis O-methyltransferase; This model represents an O-methyltransferase believed to act at two points in the ubiquinone biosynthetic pathway in bacteria (UbiG) and fungi (COQ3). A separate methylase (MenG/UbiE) catalyzes the single C-methylation step. The most commonly used names for genes in this family do not indicate whether this gene is an O-methyl, or C-methyl transferase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


:

Pssm-ID: 273910  Cd Length: 224  Bit Score: 344.28  E-value: 1.43e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001   7 EIAKFSALAHRWWDPNSEFKPLHAINPLRLKWIKSFV------SLEGKKVVDIGCGGGILAESISQSGADTTGIDLSEKA 80
Cdd:TIGR01983   1 EIAKFSALAHEWWDPNGKFKPLHKMNPLRLDYIRDRIrknfknPLDGLRVLDVGCGGGLLSEPLARLGANVTGIDASEEN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  81 LKVAELHALEVGANLTYRSISAEALADEQPEQYDVVTCMEMLEHVPDPASVVRACAKLCKPGGTLFFSTLNRSPKSYLFA 160
Cdd:TIGR01983  81 IEVAKLHAKKDPLQIDYRCTTVEDLAEKKAGSFDVVTCMEVLEHVPDPQAFIRACAQLLKPGGILFFSTINRTPKSYLLA 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2054967001 161 IIGAEYILKLLPRGTHEYAKFIKPSELVAFTRHAGLEMLGMKGMSYNPLTQVYSLNDDIDVNYM 224
Cdd:TIGR01983 161 IVGAEYILRIVPKGTHDWEKFIKPSELLSWLESAGLRVKDIKGLVYNPIKNTWKLSKDTDVNYM 224
 
Name Accession Description Interval E-value
UbiG TIGR01983
ubiquinone biosynthesis O-methyltransferase; This model represents an O-methyltransferase ...
 7-224 1.43e-121

ubiquinone biosynthesis O-methyltransferase; This model represents an O-methyltransferase believed to act at two points in the ubiquinone biosynthetic pathway in bacteria (UbiG) and fungi (COQ3). A separate methylase (MenG/UbiE) catalyzes the single C-methylation step. The most commonly used names for genes in this family do not indicate whether this gene is an O-methyl, or C-methyl transferase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273910  Cd Length: 224  Bit Score: 344.28  E-value: 1.43e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001   7 EIAKFSALAHRWWDPNSEFKPLHAINPLRLKWIKSFV------SLEGKKVVDIGCGGGILAESISQSGADTTGIDLSEKA 80
Cdd:TIGR01983   1 EIAKFSALAHEWWDPNGKFKPLHKMNPLRLDYIRDRIrknfknPLDGLRVLDVGCGGGLLSEPLARLGANVTGIDASEEN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  81 LKVAELHALEVGANLTYRSISAEALADEQPEQYDVVTCMEMLEHVPDPASVVRACAKLCKPGGTLFFSTLNRSPKSYLFA 160
Cdd:TIGR01983  81 IEVAKLHAKKDPLQIDYRCTTVEDLAEKKAGSFDVVTCMEVLEHVPDPQAFIRACAQLLKPGGILFFSTINRTPKSYLLA 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2054967001 161 IIGAEYILKLLPRGTHEYAKFIKPSELVAFTRHAGLEMLGMKGMSYNPLTQVYSLNDDIDVNYM 224
Cdd:TIGR01983 161 IVGAEYILRIVPKGTHDWEKFIKPSELLSWLESAGLRVKDIKGLVYNPIKNTWKLSKDTDVNYM 224
PLN02396 PLN02396
hexaprenyldihydroxybenzoate methyltransferase
 2-224 5.08e-74

hexaprenyldihydroxybenzoate methyltransferase


Pssm-ID: 178018 [Multi-domain]  Cd Length: 322  Bit Score: 227.31  E-value: 5.08e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001   2 NVDQSEIAKFSALAHRWWDPNSEFKPLHAINPLRLKWIKSFV------------SLEGKKVVDIGCGGGILAESISQSGA 69
Cdd:PLN02396   75 SLNEDELAKFSAIADTWWHSEGPFKPLHQMNPTRLAFIRSTLcrhfskdpssakPFEGLKFIDIGCGGGLLSEPLARMGA 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  70 DTTGIDLSEKALKVAELHAL--EVGANLTYRSISAEALADEQpEQYDVVTCMEMLEHVPDPASVVRACAKLCKPGGTLFF 147
Cdd:PLN02396  155 TVTGVDAVDKNVKIARLHADmdPVTSTIEYLCTTAEKLADEG-RKFDAVLSLEVIEHVANPAEFCKSLSALTIPNGATVL 233

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2054967001 148 STLNRSPKSYLFAIIGAEYILKLLPRGTHEYAKFIKPSELVAFTRHAGLEMLGMKGMSYNPLTQVYSLNDDIDVNYM 224
Cdd:PLN02396  234 STINRTMRAYASTIVGAEYILRWLPKGTHQWSSFVTPEELSMILQRASVDVKEMAGFVYNPITGRWLLSDDISVNYI 310
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 15-151 3.38e-41

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 136.69  E-value: 3.38e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  15 AHRWWDPnsefkplhainplRL-KWIKSFVsLEGKKVVDIGCGGGILAESISQSGADTTGIDLSEKALKVAELHALEVga 93
Cdd:COG2227     6 ARDFWDR-------------RLaALLARLL-PAGGRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARERAAEL-- 69

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2054967001  94 NLTYRSISAEALADEqPEQYDVVTCMEMLEHVPDPASVVRACAKLCKPGGTLFFSTLN 151
Cdd:COG2227    70 NVDFVQGDLEDLPLE-DGSFDLVICSEVLEHLPDPAALLRELARLLKPGGLLLLSTPN 126
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 46-199 2.39e-25

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 97.11  E-value: 2.39e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  46 EGKKVVDIGCGGGILAESISQSGADTTGIDLSEKALKVAELHALEVGANltyrsisaEALADEQPEQYDVVTCMEMLEHV 125
Cdd:pfam13489  22 SPGRVLDFGCGTGIFLRLLRAQGFSVTGVDPSPIAIERALLNVRFDQFD--------EQEAAVPAGKFDVIVAREVLEHV 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2054967001 126 PDPASVVRACAKLCKPGGTLFFSTLNRSPKsylfAIIGAEYILKLLPRGTHeyAKFIKPSELVAFTRHAGLEML 199
Cdd:pfam13489  94 PDPPALLRQIAALLKPGGLLLLSTPLASDE----ADRLLLEWPYLRPRNGH--ISLFSARSLKRLLEEAGFEVV 161
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 49-148 2.05e-14

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 66.68  E-value: 2.05e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  49 KVVDIGCGGGILAESI-SQSGADTTGIDLSEKALKVAE-LHALEVGANLTYRSISAEALADEQPEQYDVVTCMEMLEH-V 125
Cdd:cd02440     1 RVLDLGCGTGALALALaSGPGARVTGVDISPVALELARkAAAALLADNVEVLKGDAEELPPEADESFDVIISDPPLHHlV 80

                          90       100
                  ....*....|....*....|...
gi 2054967001 126 PDPASVVRACAKLCKPGGTLFFS 148
Cdd:cd02440    81 EDLARFLEEARRLLKPGGVLVLT 103
 
Name Accession Description Interval E-value
UbiG TIGR01983
ubiquinone biosynthesis O-methyltransferase; This model represents an O-methyltransferase ...
 7-224 1.43e-121

ubiquinone biosynthesis O-methyltransferase; This model represents an O-methyltransferase believed to act at two points in the ubiquinone biosynthetic pathway in bacteria (UbiG) and fungi (COQ3). A separate methylase (MenG/UbiE) catalyzes the single C-methylation step. The most commonly used names for genes in this family do not indicate whether this gene is an O-methyl, or C-methyl transferase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273910  Cd Length: 224  Bit Score: 344.28  E-value: 1.43e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001   7 EIAKFSALAHRWWDPNSEFKPLHAINPLRLKWIKSFV------SLEGKKVVDIGCGGGILAESISQSGADTTGIDLSEKA 80
Cdd:TIGR01983   1 EIAKFSALAHEWWDPNGKFKPLHKMNPLRLDYIRDRIrknfknPLDGLRVLDVGCGGGLLSEPLARLGANVTGIDASEEN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  81 LKVAELHALEVGANLTYRSISAEALADEQPEQYDVVTCMEMLEHVPDPASVVRACAKLCKPGGTLFFSTLNRSPKSYLFA 160
Cdd:TIGR01983  81 IEVAKLHAKKDPLQIDYRCTTVEDLAEKKAGSFDVVTCMEVLEHVPDPQAFIRACAQLLKPGGILFFSTINRTPKSYLLA 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2054967001 161 IIGAEYILKLLPRGTHEYAKFIKPSELVAFTRHAGLEMLGMKGMSYNPLTQVYSLNDDIDVNYM 224
Cdd:TIGR01983 161 IVGAEYILRIVPKGTHDWEKFIKPSELLSWLESAGLRVKDIKGLVYNPIKNTWKLSKDTDVNYM 224
PLN02396 PLN02396
hexaprenyldihydroxybenzoate methyltransferase
 2-224 5.08e-74

hexaprenyldihydroxybenzoate methyltransferase


Pssm-ID: 178018 [Multi-domain]  Cd Length: 322  Bit Score: 227.31  E-value: 5.08e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001   2 NVDQSEIAKFSALAHRWWDPNSEFKPLHAINPLRLKWIKSFV------------SLEGKKVVDIGCGGGILAESISQSGA 69
Cdd:PLN02396   75 SLNEDELAKFSAIADTWWHSEGPFKPLHQMNPTRLAFIRSTLcrhfskdpssakPFEGLKFIDIGCGGGLLSEPLARMGA 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  70 DTTGIDLSEKALKVAELHAL--EVGANLTYRSISAEALADEQpEQYDVVTCMEMLEHVPDPASVVRACAKLCKPGGTLFF 147
Cdd:PLN02396  155 TVTGVDAVDKNVKIARLHADmdPVTSTIEYLCTTAEKLADEG-RKFDAVLSLEVIEHVANPAEFCKSLSALTIPNGATVL 233

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2054967001 148 STLNRSPKSYLFAIIGAEYILKLLPRGTHEYAKFIKPSELVAFTRHAGLEMLGMKGMSYNPLTQVYSLNDDIDVNYM 224
Cdd:PLN02396  234 STINRTMRAYASTIVGAEYILRWLPKGTHQWSSFVTPEELSMILQRASVDVKEMAGFVYNPITGRWLLSDDISVNYI 310
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 15-151 3.38e-41

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 136.69  E-value: 3.38e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  15 AHRWWDPnsefkplhainplRL-KWIKSFVsLEGKKVVDIGCGGGILAESISQSGADTTGIDLSEKALKVAELHALEVga 93
Cdd:COG2227     6 ARDFWDR-------------RLaALLARLL-PAGGRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARERAAEL-- 69

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2054967001  94 NLTYRSISAEALADEqPEQYDVVTCMEMLEHVPDPASVVRACAKLCKPGGTLFFSTLN 151
Cdd:COG2227    70 NVDFVQGDLEDLPLE-DGSFDLVICSEVLEHLPDPAALLRELARLLKPGGLLLLSTPN 126
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 46-162 1.76e-27

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 101.99  E-value: 1.76e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  46 EGKKVVDIGCGGGILAESISQSGADTTGIDLSEKALKVAELHALEVGANLTYRSISAEALaDEQPEQYDVVTCMEMLEHV 125
Cdd:COG2226    22 PGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAGLNVEFVVGDAEDL-PFPDGSFDLVISSFVLHHL 100

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2054967001 126 PDPASVVRACAKLCKPGGTLFFSTLNRSPKSYLFAII 162
Cdd:COG2226   101 PDPERALAEIARVLKPGGRLVVVDFSPPDLAELEELL 137
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 46-199 2.39e-25

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 97.11  E-value: 2.39e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  46 EGKKVVDIGCGGGILAESISQSGADTTGIDLSEKALKVAELHALEVGANltyrsisaEALADEQPEQYDVVTCMEMLEHV 125
Cdd:pfam13489  22 SPGRVLDFGCGTGIFLRLLRAQGFSVTGVDPSPIAIERALLNVRFDQFD--------EQEAAVPAGKFDVIVAREVLEHV 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2054967001 126 PDPASVVRACAKLCKPGGTLFFSTLNRSPKsylfAIIGAEYILKLLPRGTHeyAKFIKPSELVAFTRHAGLEML 199
Cdd:pfam13489  94 PDPPALLRQIAALLKPGGLLLLSTPLASDE----ADRLLLEWPYLRPRNGH--ISLFSARSLKRLLEEAGFEVV 161
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 51-147 1.52e-23

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 90.42  E-value: 1.52e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  51 VDIGCGGGILAESISQSGADTTGIDLSEKALKVAELHAleVGANLTYRSISAEAL--ADEQpeqYDVVTCMEMLEHVPDP 128
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKA--PREGLTFVVGDAEDLpfPDNS---FDLVLSSEVLHHVEDP 75

                          90
                  ....*....|....*....
gi 2054967001 129 ASVVRACAKLCKPGGTLFF 147
Cdd:pfam08241  76 ERALREIARVLKPGGILII 94
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 50-143 4.62e-23

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 89.16  E-value: 4.62e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  50 VVDIGCGGGILAESISQS-GADTTGIDLSEKALKVAELHALEVGANLTYRSISAEALaDEQPEQYDVVTCMEMLEHVPDP 128
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRgGARVTGVDLSPEMLERARERAAEAGLNVEFVQGDAEDL-PFPDGSFDLVVSSGVLHHLPDP 79

                          90
                  ....*....|....*..
gi 2054967001 129 --ASVVRACAKLCKPGG 143
Cdd:pfam13649  80 dlEAALREIARVLKPGG 96
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
1-192 8.87e-21

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 85.82  E-value: 8.87e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001   1 MNVDQSEIAKFSALAHRWwDpNSEFKPLHAINPLRL--KWIKSFVSLEGKKVVDIGCGGGILAESISQSGADTTGIDLSE 78
Cdd:COG4976     1 MALDAYVEALFDQYADSY-D-AALVEDLGYEAPALLaeELLARLPPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  79 KALKVAElhalevgANLTYRSISAEALAD--EQPEQYDVVTCMEMLEHVPDPASVVRACAKLCKPGGTLFFSTlNRSPKS 156
Cdd:COG4976    79 EMLAKAR-------EKGVYDRLLVADLADlaEPDGRFDLIVAADVLTYLGDLAAVFAGVARALKPGGLFIFSV-EDADGS 150

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2054967001 157 YLFAiIGAEYILKLLPRgtheyAKFIKPSELVAFTR 192
Cdd:COG4976   151 GRYA-HSLDYVRDLLAA-----AGFEVPGLLVVARK 180
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 47-149 9.28e-19

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 79.59  E-value: 9.28e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  47 GKKVVDIGCGGGILAESISQS-GADTTGIDLSEKALKVAELHALEVGANLTYRSISAEALADEQPEQYDVVTCMEMLEHV 125
Cdd:COG2230    52 GMRVLDIGCGWGGLALYLARRyGVRVTGVTLSPEQLEYARERAAEAGLADRVEVRLADYRDLPADGQFDAIVSIGMFEHV 131

                          90       100
                  ....*....|....*....|....*.
gi 2054967001 126 PDP--ASVVRACAKLCKPGGTLFFST 149
Cdd:COG2230   132 GPEnyPAYFAKVARLLKPGGRLLLHT 157
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
46-149 1.14e-18

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 77.94  E-value: 1.14e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  46 EGKKVVDIGCGGGILAESISQ--SGADTTGIDLSEKALKvaelHALEVGANLTYRSISAEALADeqPEQYDVVTCMEMLE 123
Cdd:COG4106     1 PPRRVLDLGCGTGRLTALLAErfPGARVTGVDLSPEMLA----RARARLPNVRFVVADLRDLDP--PEPFDLVVSNAALH 74

                          90       100
                  ....*....|....*....|....*.
gi 2054967001 124 HVPDPASVVRACAKLCKPGGTLFFST 149
Cdd:COG4106    75 WLPDHAALLARLAAALAPGGVLAVQV 100
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 51-145 4.12e-18

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 76.25  E-value: 4.12e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  51 VDIGCGGGILAESI--SQSGADTTGIDLSEKALKVA--ELHALEVGANLTYRsISAEALADEQPEQYDVVTCMEMLEHVP 126
Cdd:pfam08242   1 LEIGCGTGTLLRALleALPGLEYTGLDISPAALEAAreRLAALGLLNAVRVE-LFQLDLGELDPGSFDVVVASNVLHHLA 79

                          90
                  ....*....|....*....
gi 2054967001 127 DPASVVRACAKLCKPGGTL 145
Cdd:pfam08242  80 DPRAVLRNIRRLLKPGGVL 98
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 18-148 5.41e-16

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 73.41  E-value: 5.41e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  18 WWD--PNSEFKPLHAINPLRLKWIKsfvslEGKKVVDIGCGGGILAESISQS-GADTTGIDLSEKALKVA-ELHALEVGA 93
Cdd:COG0500     1 PWDsyYSDELLPGLAALLALLERLP-----KGGRVLDLGCGTGRNLLALAARfGGRVIGIDLSPEAIALArARAAKAGLG 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2054967001  94 NLTYRSISAEALADEQPEQYDVVTCMEMLEHVP--DPASVVRACAKLCKPGGTLFFS 148
Cdd:COG0500    76 NVEFLVADLAELDPLPAESFDLVVAFGVLHHLPpeEREALLRELARALKPGGVLLLS 132
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 36-174 6.75e-15

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 71.02  E-value: 6.75e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  36 LKWIKSFVSLEGKKVVDIGCGGGILAESISQSGADTTGIDLSEKALKVAELHALEVG--ANLTYRSISAEALAdeqpEQY 113
Cdd:PRK07580   53 LSWLPADGDLTGLRILDAGCGVGSLSIPLARRGAKVVASDISPQMVEEARERAPEAGlaGNITFEVGDLESLL----GRF 128

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2054967001 114 DVVTCMEMLEHVPDPAsVVRACAKLCK-PGGTLFFSTlnrSPKSYLFAI---IGaeyilKLLPRG 174
Cdd:PRK07580  129 DTVVCLDVLIHYPQED-AARMLAHLASlTRGSLIFTF---APYTPLLALlhwIG-----GLFPGP 184
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 49-148 2.05e-14

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 66.68  E-value: 2.05e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  49 KVVDIGCGGGILAESI-SQSGADTTGIDLSEKALKVAE-LHALEVGANLTYRSISAEALADEQPEQYDVVTCMEMLEH-V 125
Cdd:cd02440     1 RVLDLGCGTGALALALaSGPGARVTGVDISPVALELARkAAAALLADNVEVLKGDAEELPPEADESFDVIISDPPLHHlV 80

                          90       100
                  ....*....|....*....|...
gi 2054967001 126 PDPASVVRACAKLCKPGGTLFFS 148
Cdd:cd02440    81 EDLARFLEEARRLLKPGGVLVLT 103
PRK08317 PRK08317
hypothetical protein; Provisional
 46-145 9.27e-13

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 65.34  E-value: 9.27e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  46 EGKKVVDIGCGGGILAESISQ---SGADTTGIDLSEKALKVAELHALEVGANLTYRSISAEAL--ADEQpeqYDVVTCME 120
Cdd:PRK08317   19 PGDRVLDVGCGPGNDARELARrvgPEGRVVGIDRSEAMLALAKERAAGLGPNVEFVRGDADGLpfPDGS---FDAVRSDR 95

                          90       100
                  ....*....|....*....|....*
gi 2054967001 121 MLEHVPDPASVVRACAKLCKPGGTL 145
Cdd:PRK08317   96 VLQHLEDPARALAEIARVLRPGGRV 120
PLN02244 PLN02244
tocopherol O-methyltransferase
 48-149 5.80e-12

tocopherol O-methyltransferase


Pssm-ID: 215135 [Multi-domain]  Cd Length: 340  Bit Score: 64.00  E-value: 5.80e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  48 KKVVDIGCGGGILAESISQS-GADTTGIDLSEKALKVA-ELHALE-VGANLTYRSisAEALadEQP---EQYDVVTCMEM 121
Cdd:PLN02244  120 KRIVDVGCGIGGSSRYLARKyGANVKGITLSPVQAARAnALAAAQgLSDKVSFQV--ADAL--NQPfedGQFDLVWSMES 195

                          90       100
                  ....*....|....*....|....*...
gi 2054967001 122 LEHVPDPASVVRACAKLCKPGGTLFFST 149
Cdd:PLN02244  196 GEHMPDKRKFVQELARVAAPGGRIIIVT 223
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 36-150 9.43e-12

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 62.30  E-value: 9.43e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  36 LKWIKSFVSLEGKKVVDIGCGGGILAESISQSG--ADTTGIDLSEKALKVAELHaleVGANLTYRSISAEALaDEQPEQY 113
Cdd:TIGR02072  24 LALLKEKGIFIPASVLDIGCGTGYLTRALLKRFpqAEFIALDISAGMLAQAKTK---LSENVQFICGDAEKL-PLEDSSF 99

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2054967001 114 DVVTCMEMLEHVPDPASVVRACAKLCKPGGTLFFSTL 150
Cdd:TIGR02072 100 DLIVSNLALQWCDDLSQALSELARVLKPGGLLAFSTF 136
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 46-151 9.84e-12

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 60.89  E-value: 9.84e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  46 EGKKVVDIGCGGG---ILAESISQSGADTTGIDLSEKALKVAELHALEVG-ANLTYRSISAEALA-DEQPEQYDVVTCME 120
Cdd:pfam13847   3 KGMRVLDLGCGTGhlsFELAEELGPNAEVVGIDISEEAIEKARENAQKLGfDNVEFEQGDIEELPeLLEDDKFDVVISNC 82

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2054967001 121 MLEHVPDPASVVRACAKLCKPGGTLFFSTLN 151
Cdd:pfam13847  83 VLNHIPDPDKVLQEILRVLKPGGRLIISDPD 113
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 29-148 4.00e-11

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 61.13  E-value: 4.00e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  29 HAINPLRLKWIKSFVsLEGKKVVDIGCGGGILAESISQSGAD-TTGIDLSEKALKVAELHALEVGANltyRSISAEALAD 107
Cdd:pfam06325 145 HPTTKLCLEALERLV-KPGESVLDVGCGSGILAIAALKLGAKkVVGVDIDPVAVRAAKENAELNGVE---ARLEVYLPGD 220

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2054967001 108 EQPEQYDVVTC-------MEMLEHVpdpasvvracAKLCKPGGTLFFS 148
Cdd:pfam06325 221 LPKEKADVVVAniladplIELAPDI----------YALVKPGGYLILS 258
PRK06202 PRK06202
hypothetical protein; Provisional
 50-175 4.29e-11

hypothetical protein; Provisional


Pssm-ID: 180466 [Multi-domain]  Cd Length: 232  Bit Score: 60.40  E-value: 4.29e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  50 VVDIGCGGGILAESIS----QSGAD--TTGIDLSEKALKVAELHAleVGANLTYRSISAEALADEqPEQYDVVTCMEMLE 123
Cdd:PRK06202   64 LLDIGCGGGDLAIDLArwarRDGLRleVTAIDPDPRAVAFARANP--RRPGVTFRQAVSDELVAE-GERFDVVTSNHFLH 140

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2054967001 124 HVpDPASVVR---ACAKLCKpgGTLFFSTLNRSPKSYLFAIIGAeyilKLLPRGT 175
Cdd:PRK06202  141 HL-DDAEVVRllaDSAALAR--RLVLHNDLIRSRLAYALFWAGT----RLLSRSS 188
PLN02585 PLN02585
magnesium protoporphyrin IX methyltransferase
 36-127 8.93e-10

magnesium protoporphyrin IX methyltransferase


Pssm-ID: 215319 [Multi-domain]  Cd Length: 315  Bit Score: 57.56  E-value: 8.93e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  36 LKWIKSFVSLEGKKVVDIGCGGGILAESISQSGADTTGIDLSEKALKVAELHALEVGANLTYRSISA-EALADEQPE-QY 113
Cdd:PLN02585  134 LLWLAEDGSLAGVTVCDAGCGTGSLAIPLALEGAIVSASDISAAMVAEAERRAKEALAALPPEVLPKfEANDLESLSgKY 213

                          90
                  ....*....|....
gi 2054967001 114 DVVTCMEMLEHVPD 127
Cdd:PLN02585  214 DTVTCLDVLIHYPQ 227
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 37-205 1.23e-09

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 56.31  E-value: 1.23e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  37 KWIKSFVSL----EGKKVVDIGCGGGILAESISQSGADT---TGIDLSEKALKVAE--LHALEVGANLTYRSISAEAL-- 105
Cdd:PRK00216   38 VWRRKTIKWlgvrPGDKVLDLACGTGDLAIALAKAVGKTgevVGLDFSEGMLAVGRekLRDLGLSGNVEFVQGDAEALpf 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001 106 ADeqpEQYDVVTcmeM---LEHVPDPASVVRACAKLCKPGGTLF---FSTlnrsPKSYLFAIIGAEYILKLLPR------ 173
Cdd:PRK00216  118 PD---NSFDAVT---IafgLRNVPDIDKALREMYRVLKPGGRLVileFSK----PTNPPLKKAYDFYLFKVLPLigklis 187

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2054967001 174 -GTHEYA-------KFIKPSELVAFTRHAGLEMLGMKGMS 205
Cdd:PRK00216  188 kNAEAYSylaesirAFPDQEELAAMLEEAGFERVRYRNLT 227
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
36-148 9.75e-09

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 54.00  E-value: 9.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  36 LKWIKSFVsLEGKKVVDIGCGGGILAESISQSGA-DTTGIDLSEKALKVAELHALEVGANLtyrsisAEALADEQPeQYD 114
Cdd:PRK00517  110 LEALEKLV-LPGKTVLDVGCGSGILAIAAAKLGAkKVLAVDIDPQAVEAARENAELNGVEL------NVYLPQGDL-KAD 181

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2054967001 115 VVTC-------MEMLEHVpdpasvvracAKLCKPGGTLFFS 148
Cdd:PRK00517  182 VIVAnilanplLELAPDL----------ARLLKPGGRLILS 212
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
45-116 9.22e-08

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 50.67  E-value: 9.22e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2054967001  45 LEGKKVVDIGCGGGILAE-SISQSGADTTGIDLSEKALKVAELHALEVGANLTYrsISAEALADEQPEQYDVV 116
Cdd:COG2263    44 IEGKTVLDLGCGTGMLAIgAALLGAKKVVGVDIDPEALEIARENAERLGVRVDF--IRADVTRIPLGGSVDTV 114
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
36-148 9.49e-08

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 51.33  E-value: 9.49e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  36 LKWIKSFVsLEGKKVVDIGCGGGILAESISQSGADT-TGIDLSEKALKV----AELHALEvganltyRSISAEALADEQP 110
Cdd:COG2264   139 LEALEKLL-KPGKTVLDVGCGSGILAIAAAKLGAKRvLAVDIDPVAVEAarenAELNGVE-------DRIEVVLGDLLED 210

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2054967001 111 EQYDVVTC-------MEMLEHVpdpasvvracAKLCKPGGTLFFS 148
Cdd:COG2264   211 GPYDLVVAnilanplIELAPDL----------AALLKPGGYLILS 245
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 42-147 2.39e-07

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 49.76  E-value: 2.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  42 FVSLE-GKKVVDIGCGGGILAESISQ--SGADTTGIDLSEKAlkvAELhALE-VGAN-LTYR------SIsAEALADEQP 110
Cdd:COG4123    32 FAPVKkGGRVLDLGTGTGVIALMLAQrsPGARITGVEIQPEA---AEL-ARRnVALNgLEDRitvihgDL-KEFAAELPP 106

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2054967001 111 EQYDVVTC----MEMLEHV--PDPA-------------SVVRACAKLCKPGGTLFF 147
Cdd:COG4123   107 GSFDLVVSnppyFKAGSGRksPDEAraiarhedaltleDLIRAAARLLKPGGRFAL 162
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
45-145 8.04e-07

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 48.20  E-value: 8.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  45 LEGKKVVDIGCGGG----ILAESISQSGaDTTGIDLSEKALKVAELHALEVG-ANLTYRSISAEALADEQpEQYDVVTCM 119
Cdd:pfam01209  41 KRGNKFLDVAGGTGdwtfGLSDSAGSSG-KVVGLDINENMLKEGEKKAKEEGkYNIEFLQGNAEELPFED-DSFDIVTIS 118

                          90       100
                  ....*....|....*....|....*.
gi 2054967001 120 EMLEHVPDPASVVRACAKLCKPGGTL 145
Cdd:pfam01209 119 FGLRNFPDYLKVLKEAFRVLKPGGRV 144
RlmK COG1092
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ...
 68-149 8.55e-07

23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440709 [Multi-domain]  Cd Length: 392  Bit Score: 48.64  E-value: 8.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  68 GAD-TTGIDLSEKALKVAELHALEVGANLTYRSISAEAL-----ADEQPEQYDVVTCmemlehvpDP------------- 128
Cdd:COG1092   238 GAKsVTSVDLSATALEWAKENAALNGLDDRHEFVQADAFdwlreLAREGERFDLIIL--------DPpafakskkdlfda 309

                          90       100
                  ....*....|....*....|....*
gi 2054967001 129 ----ASVVRACAKLCKPGGTLFFST 149
Cdd:COG1092   310 qrdyKDLNRLALKLLAPGGILVTSS 334
prmA TIGR00406
ribosomal protein L11 methyltransferase; Ribosomal protein L11 methyltransferase is an ...
 29-148 1.02e-06

ribosomal protein L11 methyltransferase; Ribosomal protein L11 methyltransferase is an S-adenosyl-L-methionine-dependent methyltransferase required for the modification of ribosomal protein L11. This protein is found in bacteria and (with a probable transit peptide) in Arabidopsis. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273061  Cd Length: 288  Bit Score: 48.29  E-value: 1.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  29 HAINPLRLKWIKSFVsLEGKKVVDIGCGGGILAESISQSGADTT-GIDLSEKALKVAELhalevgaNLTYRSISAEAL-- 105
Cdd:TIGR00406 143 HPTTSLCLEWLEDLD-LKDKNVIDVGCGSGILSIAALKLGAAKVvGIDIDPLAVESARK-------NAELNQVSDRLQvk 214

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2054967001 106 --ADEQP--EQYDVVTCMEMLEHVPDPASVVracAKLCKPGGTLFFS 148
Cdd:TIGR00406 215 liYLEQPieGKADVIVANILAEVIKELYPQF---SRLVKPGGWLILS 258
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 34-147 2.51e-06

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 47.07  E-value: 2.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  34 LRLKWIKSfvsLEGKKVVDIGCGGGILAESISQ--SGADTTGIDLSEKALKVAE--LHALEVGANLT-YRSISAEALADE 108
Cdd:COG2890   103 LALALLPA---GAPPRVLDLGTGSGAIALALAKerPDARVTAVDISPDALAVARrnAERLGLEDRVRfLQGDLFEPLPGD 179

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2054967001 109 QpeQYDVVTC---------MEML-----EHvpDPAS--------------VVRACAKLCKPGGTLFF 147
Cdd:COG2890   180 G--RFDLIVSnppyipedeIALLppevrDH--EPRLaldggedgldfyrrIIAQAPRLLKPGGWLLL 242
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
39-122 1.17e-05

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 45.03  E-value: 1.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  39 IKSFVsLEGKKVVDIGCGGGILAESISQSGADT-TGIDLSEKALKVAELHALEVGANLTYRSISAEALADEQPEQYDVVT 117
Cdd:COG4076    29 IERVV-KPGDVVLDIGTGSGLLSMLAARAGAKKvYAVEVNPDIAAVARRIIAANGLSDRITVINADATDLDLPEKADVII 107


                  ....*
gi 2054967001 118 CmEML 122
Cdd:COG4076   108 S-EML 111
PRK11036 PRK11036
tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;
50-145 1.65e-05

tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;


Pssm-ID: 182918  Cd Length: 255  Bit Score: 44.57  E-value: 1.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  50 VVDIGCGGGILAESISQSGADTTGIDLSEKALKVAELHALEVG--ANLTYRSISAEALADEQPEQYDVVTCMEMLEHVPD 127
Cdd:PRK11036   48 VLDAGGGEGQTAIKLAELGHQVILCDLSAEMIQRAKQAAEAKGvsDNMQFIHCAAQDIAQHLETPVDLILFHAVLEWVAD 127

                          90
                  ....*....|....*...
gi 2054967001 128 PASVVRACAKLCKPGGTL 145
Cdd:PRK11036  128 PKSVLQTLWSVLRPGGAL 145
PLN02336 PLN02336
phosphoethanolamine N-methyltransferase
 40-167 3.04e-05

phosphoethanolamine N-methyltransferase


Pssm-ID: 177970 [Multi-domain]  Cd Length: 475  Bit Score: 44.36  E-value: 3.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  40 KSFVSL----EGKKVVDIGCG--GG--ILAESIsqsGADTTGIDLSEKALKVAELHAleVGANLTYRSISAEALADEQPE 111
Cdd:PLN02336  256 KEFVDKldlkPGQKVLDVGCGigGGdfYMAENF---DVHVVGIDLSVNMISFALERA--IGRKCSVEFEVADCTKKTYPD 330

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2054967001 112 Q-YDVVTCMEMLEHVPDPASVVRACAKLCKPGGTLFFSTLNRSPK--SYLFaiigAEYI 167
Cdd:PLN02336  331 NsFDVIYSRDTILHIQDKPALFRSFFKWLKPGGKVLISDYCRSPGtpSPEF----AEYI 385
CMAS pfam02353
Mycolic acid cyclopropane synthetase; This family consist of ...
 29-125 4.02e-05

Mycolic acid cyclopropane synthetase; This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyze the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.


Pssm-ID: 396777 [Multi-domain]  Cd Length: 272  Bit Score: 43.47  E-value: 4.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  29 HAINPLRLKwiksfvslEGKKVVDIGCG-GGILAESISQSGADTTGIDLSEKALKVAELHALEVGANltyRSISAEALAD 107
Cdd:pfam02353  52 LILDKLGLK--------PGMTLLDIGCGwGGLMRRAAERYDVNVVGLTLSKNQYKLARKRVAAEGLA---RKVEVLLQDY 120

                          90
                  ....*....|....*....
gi 2054967001 108 EQ-PEQYDVVTCMEMLEHV 125
Cdd:pfam02353 121 RDfDEPFDRIVSVGMFEHV 139
PRK14968 PRK14968
putative methyltransferase; Provisional
 46-88 8.67e-05

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 41.81  E-value: 8.67e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2054967001  46 EGKKVVDIGCGGGILAESISQSGADTTGIDLSEKALKVAELHA 88
Cdd:PRK14968   23 KGDRVLEVGTGSGIVAIVAAKNGKKVVGVDINPYAVECAKCNA 65
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 46-85 1.30e-04

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 42.07  E-value: 1.30e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2054967001  46 EGKKVVDIGCGGGILAESISQS--GADTTGIDLSEKALKVAE 85
Cdd:PRK09328  108 EPLRVLDLGTGSGAIALALAKErpDAEVTAVDISPEALAVAR 149
RsmG COG0357
16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) [Translation, ...
 42-147 1.90e-04

16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) [Translation, ribosomal structure and biogenesis]; 16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440126  Cd Length: 211  Bit Score: 41.29  E-value: 1.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  42 FVSLEGKKVVDIGCGGG----ILAesISQSGADTTGIDLSEKalKVAEL----HALEVgANLTYRSISAEALAdeQPEQY 113
Cdd:COG0357    63 LLPKEGARVLDVGSGAGfpgiPLA--IARPDLQVTLVDSLGK--KIAFLrevvRELGL-KNVTVVHGRAEELA--PREKF 135

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2054967001 114 DVVTC-----MEMLehvpdpasvVRACAKLCKPGGTLFF 147
Cdd:COG0357   136 DVVTAravapLPDL---------LELALPLLKPGGRLLA 165
PRK14967 PRK14967
putative methyltransferase; Provisional
 47-156 4.52e-04

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 40.04  E-value: 4.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  47 GKKVVDIGCGGGILAESISQSGAD-TTGIDLSEKALKVAELHALEVGANLTYRSISAEALADEQPeqYDVVTCMEmlEHV 125
Cdd:PRK14967   37 GRRVLDLCTGSGALAVAAAAAGAGsVTAVDISRRAVRSARLNALLAGVDVDVRRGDWARAVEFRP--FDVVVSNP--PYV 112

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2054967001 126 PDPASVV--------------------RACA---KLCKPGGTLFF--STLNRSPKS 156
Cdd:PRK14967  113 PAPPDAPpsrgparawdagpdgravldRLCDaapALLAPGGSLLLvqSELSGVERT 168
PRK14103 PRK14103
trans-aconitate 2-methyltransferase; Provisional
 45-147 1.08e-03

trans-aconitate 2-methyltransferase; Provisional


Pssm-ID: 184509  Cd Length: 255  Bit Score: 39.29  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  45 LEGKKVVDIGCGGGILAESISQS--GADTTGIDLSEKALKVAELHALEVGanltyrsisAEALADEQPEQ-YDVVTCMEM 121
Cdd:PRK14103   28 ERARRVVDLGCGPGNLTRYLARRwpGAVIEALDSSPEMVAAARERGVDAR---------TGDVRDWKPKPdTDVVVSNAA 98

                          90       100
                  ....*....|....*....|....*.
gi 2054967001 122 LEHVPDPASVVRACAKLCKPGGTLFF 147
Cdd:PRK14103   99 LQWVPEHADLLVRWVDELAPGSWIAV 124
ADH_zinc_N pfam00107
Zinc-binding dehydrogenase;
68-147 2.66e-03

Zinc-binding dehydrogenase;


Pssm-ID: 395057 [Multi-domain]  Cd Length: 129  Bit Score: 36.82  E-value: 2.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  68 GADTTGIDLSEKALKvaelHALEVGANLTYRS----ISAEALADEQPEQYDVVtcmemLEHVPDPASvVRACAKLCKPGG 143
Cdd:pfam00107  14 GAKVIAVDGSEEKLE----LAKELGADHVINPketdLVEEIKELTGGKGVDVV-----FDCVGSPAT-LEQALKLLRPGG 83


                  ....
gi 2054967001 144 TLFF 147
Cdd:pfam00107  84 RVVV 87
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 46-118 3.01e-03

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 37.48  E-value: 3.01e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2054967001  46 EGKKVVDIGCGGGILAESISQSGADT--TGIDLSEKALKVAELHALEVG-ANLTYrsISAEALADEQPEQYDVVTC 118
Cdd:COG2813    49 LGGRVLDLGCGYGVIGLALAKRNPEArvTLVDVNARAVELARANAAANGlENVEV--LWSDGLSGVPDGSFDLILS 122
Methyltransf_9 pfam08003
Protein of unknown function (DUF1698); This family contains many hypothetical proteins. It ...
 45-150 4.66e-03

Protein of unknown function (DUF1698); This family contains many hypothetical proteins. It also includes two putative methyltransferase proteins, Swiss:Q8EEE6 and Swiss:Q88MX8.


Pssm-ID: 429781 [Multi-domain]  Cd Length: 315  Bit Score: 37.38  E-value: 4.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  45 LEGKKVVDIGCGGGILAESISQSGAD-TTGIDLSEkaLKVAELHALEVGANLTYRSISAeALADEQ-P--EQYDVVTCME 120
Cdd:pfam08003 114 LKGRTILDVGCGNGYHMWRMLGEGAAmVVGIDPSE--LFLCQFEAVRKLLGNDQRAHLL-PLGIEQlPalAAFDTVFSMG 190

                          90       100       110
                  ....*....|....*....|....*....|
gi 2054967001 121 MLEHVPDPASVVRACAKLCKPGGTLFFSTL 150
Cdd:pfam08003 191 VLYHRRSPLDHLLQLKDQLVKGGELVLETL 220
PRK11705 PRK11705
cyclopropane fatty acyl phospholipid synthase;
47-125 5.24e-03

cyclopropane fatty acyl phospholipid synthase;


Pssm-ID: 183282  Cd Length: 383  Bit Score: 37.52  E-value: 5.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2054967001  47 GKKVVDIGCGGGILAE-SISQSGADTTGIDLSEKALKVAELHA--LEVGANLT-YRSISaealadeqpEQYDVVTCMEML 122
Cdd:PRK11705  168 GMRVLDIGCGWGGLARyAAEHYGVSVVGVTISAEQQKLAQERCagLPVEIRLQdYRDLN---------GQFDRIVSVGMF 238


                  ...
gi 2054967001 123 EHV 125
Cdd:PRK11705  239 EHV 241
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 47-118 7.80e-03

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 36.03  E-value: 7.80e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2054967001  47 GKKVVDIGCGGGILAESISQSGADT--TGIDLSEKALKVA----ELHALEVGanltyRSISAEALADEQPEQYDVVTC 118
Cdd:pfam05175  32 SGKVLDLGCGAGVLGAALAKESPDAelTMVDINARALESArenlAANGLENG-----EVVASDVYSGVEDGKFDLIIS 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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