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Conserved domains on  [gi|2044897634|ref|WP_213541313|]
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homoserine dehydrogenase [Vescimonas coprocola]

Protein Classification

homoserine dehydrogenase( domain architecture ID 11421468)

homoserine dehydrogenase catalyzes the conversion from L-homoserine and NAD(P)(+) to L-aspartate 4-semialdehyde and NAD(P)H

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ThrA COG0460
Homoserine dehydrogenase [Amino acid transport and metabolism]; Homoserine dehydrogenase is ...
 2-218 7.90e-77

Homoserine dehydrogenase [Amino acid transport and metabolism]; Homoserine dehydrogenase is part of the Pathway/BioSystem: Methionine biosynthesis


:

Pssm-ID: 440228 [Multi-domain]  Cd Length: 302  Bit Score: 236.09  E-value: 7.90e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897634   2 TANKAVISAYYRELTALACENRVALRCTAAVGGGIPWLVNLQRCRRVDTVTEVGGIMNGTTNFIMDAMARQGADFPAVLQ 81
Cdd:COG0460    80 TANKALLAEHGKELFELARKNGVDLLFEAAVGGGIPIIKTLRELLAGDRITRIEGILNGTTNYILTKMEEEGLSFSEALK 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897634  82 RAQELGYAEADPSADIDGDDIRRKLTISANIAFDALLREEDIPAFGIRTVTGADVADFRAHGFTCKLLACAQRTETGVAA 161
Cdd:COG0460   160 EAQELGYAEADPTADVEGIDAARKLAILARLAFGTPVELEDVYVEGITRITAEDIAAAKELGYVIKLLAIAERTGGGVEA 239

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2044897634 162 YVEPALVAEGEPEAAVPGNYNLISCTGELLGRQSYFGQGAGRYPTAANVVQDCLDLL 218
Cdd:COG0460   240 RVHPTLVPADHPLASVNGVDNAVLVETDAYGELMFYGPGAGAEPTASAVLADLLDIA 296
 
Name Accession Description Interval E-value
ThrA COG0460
Homoserine dehydrogenase [Amino acid transport and metabolism]; Homoserine dehydrogenase is ...
 2-218 7.90e-77

Homoserine dehydrogenase [Amino acid transport and metabolism]; Homoserine dehydrogenase is part of the Pathway/BioSystem: Methionine biosynthesis


Pssm-ID: 440228 [Multi-domain]  Cd Length: 302  Bit Score: 236.09  E-value: 7.90e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897634   2 TANKAVISAYYRELTALACENRVALRCTAAVGGGIPWLVNLQRCRRVDTVTEVGGIMNGTTNFIMDAMARQGADFPAVLQ 81
Cdd:COG0460    80 TANKALLAEHGKELFELARKNGVDLLFEAAVGGGIPIIKTLRELLAGDRITRIEGILNGTTNYILTKMEEEGLSFSEALK 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897634  82 RAQELGYAEADPSADIDGDDIRRKLTISANIAFDALLREEDIPAFGIRTVTGADVADFRAHGFTCKLLACAQRTETGVAA 161
Cdd:COG0460   160 EAQELGYAEADPTADVEGIDAARKLAILARLAFGTPVELEDVYVEGITRITAEDIAAAKELGYVIKLLAIAERTGGGVEA 239

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2044897634 162 YVEPALVAEGEPEAAVPGNYNLISCTGELLGRQSYFGQGAGRYPTAANVVQDCLDLL 218
Cdd:COG0460   240 RVHPTLVPADHPLASVNGVDNAVLVETDAYGELMFYGPGAGAEPTASAVLADLLDIA 296
PRK06349 PRK06349
homoserine dehydrogenase; Provisional
 2-251 3.35e-69

homoserine dehydrogenase; Provisional


Pssm-ID: 235783 [Multi-domain]  Cd Length: 426  Bit Score: 220.71  E-value: 3.35e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897634   2 TANKAVISAYYRELTALACENRVALRCTAAVGGGIPWLVNLQRCRRVDTVTEVGGIMNGTTNFIMDAMARQGADFPAVLQ 81
Cdd:PRK06349  102 TANKALLAVHGAELFAAAEEKGVDLYFEAAVAGGIPIIKALREGLAANRITRVMGIVNGTTNYILTKMTEEGLSFEDALK 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897634  82 RAQELGYAEADPSADIDGDDIRRKLTISANIAFDALLREEDIPAFGIRTVTGADVADFRAHGFTCKLLACAQRTETGVAA 161
Cdd:PRK06349  182 EAQRLGYAEADPTFDVEGIDAAHKLAILASLAFGTRVDFDDVYVEGISKITAEDIAYAKELGYRIKLLGIAERTEEGIEL 261

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897634 162 YVEPALVAEGEPEAAVPGNYNLISCTGELLGRQSYFGQGAGRYPTAANVVQDCLDL-----LTGEDGFYTETARPMAV-E 235
Cdd:PRK06349  262 RVHPTLIPKSHPLANVNGVMNAVFVEGDAVGETMFYGPGAGGLPTASAVVADLVDIarnlvRVPHLGFQPSALADLPIaP 341

                         250
                  ....*....|....*.
gi 2044897634 236 ADAVAHPYYVRTQAAD 251
Cdd:PRK06349  342 MEEIESKYYLRLLVAD 357
Homoserine_dh pfam00742
Homoserine dehydrogenase;
37-213 1.06e-66

Homoserine dehydrogenase;


Pssm-ID: 459921 [Multi-domain]  Cd Length: 178  Bit Score: 206.07  E-value: 1.06e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897634  37 PWLVNLQRCRRVDTVTEVGGIMNGTTNFIMDAMARQGADFPAVLQRAQELGYAEADPSADIDGDDIRRKLTISANIAFDA 116
Cdd:pfam00742   1 PIIRTLRLSLAGDRITRIEGILNGTTNYILTRMEEEGLSFSEALKEAQELGYAEADPTDDVEGIDAARKLAILARLAFGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897634 117 LLREEDIPAFGIRTVTGADVADFRAHGFTCKLLACAQRTETGVAAYVEPALVAEGEPEAAVPGNYNLISCTGELLGRQSY 196
Cdd:pfam00742  81 DVELEDVEVEGITRLTAEDIAYAKELGKVIKLVASAKRDDGGVEARVGPTLVPKDHPLASVKGVDNAVVIETDRYGELVF 160

                         170
                  ....*....|....*..
gi 2044897634 197 FGQGAGRYPTAANVVQD 213
Cdd:pfam00742 161 YGPGAGALPTASAVLAD 177
 
Name Accession Description Interval E-value
ThrA COG0460
Homoserine dehydrogenase [Amino acid transport and metabolism]; Homoserine dehydrogenase is ...
 2-218 7.90e-77

Homoserine dehydrogenase [Amino acid transport and metabolism]; Homoserine dehydrogenase is part of the Pathway/BioSystem: Methionine biosynthesis


Pssm-ID: 440228 [Multi-domain]  Cd Length: 302  Bit Score: 236.09  E-value: 7.90e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897634   2 TANKAVISAYYRELTALACENRVALRCTAAVGGGIPWLVNLQRCRRVDTVTEVGGIMNGTTNFIMDAMARQGADFPAVLQ 81
Cdd:COG0460    80 TANKALLAEHGKELFELARKNGVDLLFEAAVGGGIPIIKTLRELLAGDRITRIEGILNGTTNYILTKMEEEGLSFSEALK 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897634  82 RAQELGYAEADPSADIDGDDIRRKLTISANIAFDALLREEDIPAFGIRTVTGADVADFRAHGFTCKLLACAQRTETGVAA 161
Cdd:COG0460   160 EAQELGYAEADPTADVEGIDAARKLAILARLAFGTPVELEDVYVEGITRITAEDIAAAKELGYVIKLLAIAERTGGGVEA 239

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2044897634 162 YVEPALVAEGEPEAAVPGNYNLISCTGELLGRQSYFGQGAGRYPTAANVVQDCLDLL 218
Cdd:COG0460   240 RVHPTLVPADHPLASVNGVDNAVLVETDAYGELMFYGPGAGAEPTASAVLADLLDIA 296
PRK06349 PRK06349
homoserine dehydrogenase; Provisional
 2-251 3.35e-69

homoserine dehydrogenase; Provisional


Pssm-ID: 235783 [Multi-domain]  Cd Length: 426  Bit Score: 220.71  E-value: 3.35e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897634   2 TANKAVISAYYRELTALACENRVALRCTAAVGGGIPWLVNLQRCRRVDTVTEVGGIMNGTTNFIMDAMARQGADFPAVLQ 81
Cdd:PRK06349  102 TANKALLAVHGAELFAAAEEKGVDLYFEAAVAGGIPIIKALREGLAANRITRVMGIVNGTTNYILTKMTEEGLSFEDALK 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897634  82 RAQELGYAEADPSADIDGDDIRRKLTISANIAFDALLREEDIPAFGIRTVTGADVADFRAHGFTCKLLACAQRTETGVAA 161
Cdd:PRK06349  182 EAQRLGYAEADPTFDVEGIDAAHKLAILASLAFGTRVDFDDVYVEGISKITAEDIAYAKELGYRIKLLGIAERTEEGIEL 261

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897634 162 YVEPALVAEGEPEAAVPGNYNLISCTGELLGRQSYFGQGAGRYPTAANVVQDCLDL-----LTGEDGFYTETARPMAV-E 235
Cdd:PRK06349  262 RVHPTLIPKSHPLANVNGVMNAVFVEGDAVGETMFYGPGAGGLPTASAVVADLVDIarnlvRVPHLGFQPSALADLPIaP 341

                         250
                  ....*....|....*.
gi 2044897634 236 ADAVAHPYYVRTQAAD 251
Cdd:PRK06349  342 MEEIESKYYLRLLVAD 357
Homoserine_dh pfam00742
Homoserine dehydrogenase;
37-213 1.06e-66

Homoserine dehydrogenase;


Pssm-ID: 459921 [Multi-domain]  Cd Length: 178  Bit Score: 206.07  E-value: 1.06e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897634  37 PWLVNLQRCRRVDTVTEVGGIMNGTTNFIMDAMARQGADFPAVLQRAQELGYAEADPSADIDGDDIRRKLTISANIAFDA 116
Cdd:pfam00742   1 PIIRTLRLSLAGDRITRIEGILNGTTNYILTRMEEEGLSFSEALKEAQELGYAEADPTDDVEGIDAARKLAILARLAFGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897634 117 LLREEDIPAFGIRTVTGADVADFRAHGFTCKLLACAQRTETGVAAYVEPALVAEGEPEAAVPGNYNLISCTGELLGRQSY 196
Cdd:pfam00742  81 DVELEDVEVEGITRLTAEDIAYAKELGKVIKLVASAKRDDGGVEARVGPTLVPKDHPLASVKGVDNAVVIETDRYGELVF 160

                         170
                  ....*....|....*..
gi 2044897634 197 FGQGAGRYPTAANVVQD 213
Cdd:pfam00742 161 YGPGAGALPTASAVLAD 177
PRK06270 PRK06270
homoserine dehydrogenase; Provisional
 2-217 7.54e-44

homoserine dehydrogenase; Provisional


Pssm-ID: 235763 [Multi-domain]  Cd Length: 341  Bit Score: 152.33  E-value: 7.54e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897634   2 TANKAVISAYYRELTALACENRVALRCTAAVGGGIPwLVNLqrCRRV---DTVTEVGGIMNGTTNFIMDAMARQGADFPA 78
Cdd:PRK06270  123 TSNKGPLALAYKELKELAKKNGVRFRYEATVGGAMP-IINL--AKETlagNDIKSIKGILNGTTNYILTRMEEEGLSYEQ 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897634  79 VLQRAQELGYAEADPSADIDGDDIRRKLTISANIAFDALLREEDIPAFGIRTVTGADVADFRAHGFTCKLLACAQRTETg 158
Cdd:PRK06270  200 ALAEAQELGYAEADPTYDVEGIDAALKVVILANSILGADLTIKDVEVEGITKITPEAIELAAKEGYRIKLIGEVSREKD- 278

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2044897634 159 vaAYVEPALVAEGEPeAAVPGNYNLISCTGELLGRQSYFGQGAGRYPTAANVVQDCLDL 217
Cdd:PRK06270  279 --LSVSPRLVPLDHP-LAVSGTLNAATFETDLAGDVTVVGRGAGSIETASAILSDLIAI 334
PRK08374 PRK08374
homoserine dehydrogenase; Provisional
 1-213 1.21e-26

homoserine dehydrogenase; Provisional


Pssm-ID: 169409 [Multi-domain]  Cd Length: 336  Bit Score: 106.81  E-value: 1.21e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897634   1 MTANKAVISAYYRELTALACENRVALRCTAAVGGGIPWLVNLQRCRRVDTVTEVGGIMNGTTNFIMDAMaRQGADFPAVL 80
Cdd:PRK08374  119 VTSNKPPIAFHYDELLDLANERNLPYLFEATVMAGTPIIGLLRENLLGDTVKRIEAVVNATTTFILTRM-EQGKTFEEAL 197

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897634  81 QRAQELGYAEADPSADIDGDDIRRKLTISANIAFDAlLREEDIPAFGIRTVTGADVADFRAHGFTCKLLAcaqRTETGVA 160
Cdd:PRK08374  198 KEAQTLGIAERDPSKDIDGIDAGYKATILHWVAFPP-ITFEEVGIRGIKDVTEGEIERAKAKGRNVRLVA---TVEEGRI 273

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2044897634 161 AyVEPALVAEGEPeAAVPGNYNLISCTGELLGRQSYFGQGAGRYPTAANVVQD 213
Cdd:PRK08374  274 S-VKPKKLPENSP-LAVEGVENAAVIKTDLLGELVLKGPGAGGKETASGVVTD 324
PRK06813 PRK06813
homoserine dehydrogenase; Validated
 4-218 8.14e-19

homoserine dehydrogenase; Validated


Pssm-ID: 168683 [Multi-domain]  Cd Length: 346  Bit Score: 85.30  E-value: 8.14e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897634   4 NKAVISAYYRELTALACENRVALRCTAAVGGGIPWLVNLQRCRRVDTVTEVGGIMNGTTNFIMDAMARQGADFPAVLQRA 83
Cdd:PRK06813  122 SKGALVTNWREINEAAKIANVRIRYSGATAAALPTLDIGQFSLAGCHIEKIEGILNGTTNYILTKMNEEDITFEEALKEA 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897634  84 QELGYAEADPSADIDGDDIRRKLTISANIAFDALLREEDIPAFGIRTVTGADVADFRAHGFTCKLLACAQRTETG-VAAY 162
Cdd:PRK06813  202 QSKGIAETNPILDVSGSDSACKLLLLTNSLMGTENKLTDIHIKGIEHVTKQQIRNAKEQNKIIKLIASAYKDNEGnVNLN 281

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2044897634 163 VEPALVAEGEPEAAVPGNYNLISCTGELLGRQSYFGQGAGRYPTAANVVQDCLDLL 218
Cdd:PRK06813  282 VEPYKIEKNHPLANVNGTEKGITFFTDTMGQVTTIGGASNPRGAAAAALKDIINLY 337
PRK06392 PRK06392
homoserine dehydrogenase; Provisional
 1-128 1.82e-13

homoserine dehydrogenase; Provisional


Pssm-ID: 102354 [Multi-domain]  Cd Length: 326  Bit Score: 69.51  E-value: 1.82e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897634   1 MTANKAVISAYYRELTALACENRVALRCTAAVGGGIPWLVNLQRCRRVDTVTEVGGIMNGTTNFIMDAMArQGADFPAVL 80
Cdd:PRK06392  113 VTANKSGLANHWHDIMDSASKNRRIIRYEATVAGGVPLFSLRDYSTLPSRIKNFRGIVSSTINYVIRQEA-NGRGFLDVV 191

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2044897634  81 QRAQELGYAEADPSADIDGDDIRRKLTISANIAFDALLREEDIPAFGI 128
Cdd:PRK06392  192 KIAQKMGIAETNYSDDLMGLDAARKSVILANHLFGKDYTLRDVTYDGI 239
PLN02700 PLN02700
homoserine dehydrogenase family protein
 3-110 1.74e-10

homoserine dehydrogenase family protein


Pssm-ID: 215377 [Multi-domain]  Cd Length: 377  Bit Score: 60.94  E-value: 1.74e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897634   3 ANKAVISAYYRELTALACENRvALRCTAAVGGGIPWLVNLQRC-RRVDTVTEVGGIMNGTTNFIMDAMaRQGADFPAVLQ 81
Cdd:PLN02700  139 ANKKPLTSTLEDYDKLAAHPR-RIRHESTVGAGLPVIASLNRIlSSGDPVHRIVGSLSGTLGYVMSEL-EDGKPFSEVVK 216

                          90       100
                  ....*....|....*....|....*....
gi 2044897634  82 RAQELGYAEADPSADIDGDDIRRKLTISA 110
Cdd:PLN02700  217 QAKSLGYTEPDPRDDLGGMDVARKALILA 245
thrA PRK09436
bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional
 2-110 2.29e-09

bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional


Pssm-ID: 181856 [Multi-domain]  Cd Length: 819  Bit Score: 58.24  E-value: 2.29e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897634   2 TANKAVIS---AYYRELTALACENRVALRCTAAVGGGIPWLVNLQRCRRV-DTVTEVGGIMNGTTNFIMDaMARQGADFP 77
Cdd:PRK09436  576 TPNKKANTssyAYYHQLREAARKSRRKFLYETNVGAGLPVIETLQNLLNAgDELLKFEGILSGSLSFIFG-KLDEGMSFS 654

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2044897634  78 AVLQRAQELGYAEADPSADIDGDDIRRKLTISA 110
Cdd:PRK09436  655 EATRLAKEKGYTEPDPRDDLSGMDVARKLLILA 687
metL PRK09466
bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional
 2-110 2.51e-07

bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional


Pssm-ID: 236530 [Multi-domain]  Cd Length: 810  Bit Score: 51.85  E-value: 2.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2044897634   2 TANK---AVISAYYREL-TALAcENRVALRCTAAVGGGIPwlVN--LQRCRRV-DTVTEVGGIMNGT-----TNFimDAm 69
Cdd:PRK09466  570 SANKlagSSPSNFYRQIkDAFA-KTGRHWLYNATVGAGLP--INhtVRDLRNSgDSILAISGIFSGTlswlfLQF--DG- 643

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2044897634  70 arqGADFPAVLQRAQELGYAEADPSADIDGDDIRRKLTISA 110
Cdd:PRK09466  644 ---SVPFSELVDQAWQQGLTEPDPRDDLSGRDVMRKLVILA 681
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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