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Conserved domains on  [gi|1992224175|ref|WP_204370373|]
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glycosyltransferase [Cellulomonas flavigena]

Protein Classification

glycosyltransferase family protein( domain architecture ID 56)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glycosyltransferase_GTB-type super family cl10013
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 60-387 2.26e-47

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


The actual alignment was detected with superfamily member cd03798:

Pssm-ID: 471961 [Multi-domain]  Cd Length: 376  Bit Score: 165.63  E-value: 2.26e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175  60 RIVVPIREAAPGALSSSRAIRLVSEARGLGAMRRAITQWEPEVIHQHQATWSLP-AVGAARDTGAPLVVTVHGADAYrrl 138
Cdd:cd03798    56 EAVPPRDGRRLLPLKPRLRLLAPLRAPSLAKLLKRRRRGPPDLIHAHFAYPAGFaAALLARLYGVPYVVTEHGSDIN--- 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 139 grgpGAAWNDLNRRA---AFGGAHRLLAVSRYLADVALASGAQRRRLRVHYQGVDTAWWHPGagacDRGAGGAPGVPIVL 215
Cdd:cd03798   133 ----VFPPRSLLRKLlrwALRRAARVIAVSKALAEELVALGVPRDRVDVIPNGVDPARFQPE----DRGLGLPLDAFVIL 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 216 FVGALSHLKGVDDLVEASVRLHDAHPH-SLVLVGEGPLSSTLIA-HAPAH----VTVTGQLDREEVRDWMRRSHVLVLPT 289
Cdd:cd03798   205 FVGRLIPRKGIDLLLEAFARLAKARPDvVLLIVGDGPLREALRAlAEDLGlgdrVTFTGRLPHEQVPAYYRACDVFVLPS 284

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 290 kptrgRAEAAGLVLLEAQACGVPALAYATGGTPEMVAPGAS-VLTPGRTSTHLARTLGEAL--TWGDAERAERglacRRW 366
Cdd:cd03798   285 -----RHEGFGLVLLEAMACGLPVVATDVGGIPEVVGDPETgLLVPPGDADALAAALRRALaePYLRELGEAA----RAR 355

                         330       340
                  ....*....|....*....|.
gi 1992224175 367 VEENRSLATSADQLRAVYREV 387
Cdd:cd03798   356 VAERFSWVKAADRIAAAYRDV 376
 
Name Accession Description Interval E-value
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
 60-387 2.26e-47

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 165.63  E-value: 2.26e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175  60 RIVVPIREAAPGALSSSRAIRLVSEARGLGAMRRAITQWEPEVIHQHQATWSLP-AVGAARDTGAPLVVTVHGADAYrrl 138
Cdd:cd03798    56 EAVPPRDGRRLLPLKPRLRLLAPLRAPSLAKLLKRRRRGPPDLIHAHFAYPAGFaAALLARLYGVPYVVTEHGSDIN--- 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 139 grgpGAAWNDLNRRA---AFGGAHRLLAVSRYLADVALASGAQRRRLRVHYQGVDTAWWHPGagacDRGAGGAPGVPIVL 215
Cdd:cd03798   133 ----VFPPRSLLRKLlrwALRRAARVIAVSKALAEELVALGVPRDRVDVIPNGVDPARFQPE----DRGLGLPLDAFVIL 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 216 FVGALSHLKGVDDLVEASVRLHDAHPH-SLVLVGEGPLSSTLIA-HAPAH----VTVTGQLDREEVRDWMRRSHVLVLPT 289
Cdd:cd03798   205 FVGRLIPRKGIDLLLEAFARLAKARPDvVLLIVGDGPLREALRAlAEDLGlgdrVTFTGRLPHEQVPAYYRACDVFVLPS 284

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 290 kptrgRAEAAGLVLLEAQACGVPALAYATGGTPEMVAPGAS-VLTPGRTSTHLARTLGEAL--TWGDAERAERglacRRW 366
Cdd:cd03798   285 -----RHEGFGLVLLEAMACGLPVVATDVGGIPEVVGDPETgLLVPPGDADALAAALRRALaePYLRELGEAA----RAR 355

                         330       340
                  ....*....|....*....|.
gi 1992224175 367 VEENRSLATSADQLRAVYREV 387
Cdd:cd03798   356 VAERFSWVKAADRIAAAYRDV 376
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 212-359 1.09e-28

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 109.67  E-value: 1.09e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 212 PIVLFVGALSHLKGVDDLVEASVRLHDAHPH-SLVLVGEGPLSSTLIAHA-----PAHVTVTGQLDREEVRDWMRRSHVL 285
Cdd:pfam00534   3 KIILFVGRLEPEKGLDLLIKAFALLKEKNPNlKLVIAGDGEEEKRLKKLAeklglGDNVIFLGFVSDEDLPELLKIADVF 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1992224175 286 VLPtkptrGRAEAAGLVLLEAQACGVPALAYATGGTPEMVAPGAS-VLTPGRTSTHLARTLGEALTwgDAERAER 359
Cdd:pfam00534  83 VLP-----SRYEGFGIVLLEAMACGLPVIASDVGGPPEVVKDGETgFLVKPNNAEALAEAIDKLLE--DEELRER 150
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 278-389 1.69e-16

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 75.03  E-value: 1.69e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 278 WMRRSHVLVLPTkptrgRAEAAGLVLLEAQACGVPALAYATGGTPEMVAPGAS-VLTPGRTSTHLARTLGEALTWgDAER 356
Cdd:COG0438    17 LLAAADVFVLPS-----RSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETgLLVPPGDPEALAEAILRLLED-PELR 90

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1992224175 357 AERGLACRRWVEENRSLATSADQLRAVYREVSR 389
Cdd:COG0438    91 RRLGEAARERAEERFSWEAIAERLLALYEELLA 123
PLN02871 PLN02871
UDP-sulfoquinovose:DAG sulfoquinovosyltransferase
 158-369 2.29e-16

UDP-sulfoquinovose:DAG sulfoquinovosyltransferase


Pssm-ID: 215469 [Multi-domain]  Cd Length: 465  Bit Score: 80.53  E-value: 2.29e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 158 AHRLLAVSRYLADVALASGAQ-RRRLRVHYQGVDTAWWHP---GAGACDRGAGGAPGVPIVLFVGALSHLKGVDDLVEAS 233
Cdd:PLN02871  206 ADLTLVTSPALGKELEAAGVTaANRIRVWNKGVDSESFHPrfrSEEMRARLSGGEPEKPLIVYVGRLGAEKNLDFLKRVM 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 234 VRLHDAhphSLVLVGEGPLSSTLIAH-APAHVTVTGQLDREEVRDWMRRSHVLVLPTKptrgrAEAAGLVLLEAQACGVP 312
Cdd:PLN02871  286 ERLPGA---RLAFVGDGPYREELEKMfAGTPTVFTGMLQGDELSQAYASGDVFVMPSE-----SETLGFVVLEAMASGVP 357

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1992224175 313 ALAYATGGTPEMVAPGAS-----VLTPGRTSTHLARTlgEALTWGDAERAERGLACRRWVEE 369
Cdd:PLN02871  358 VVAARAGGIPDIIPPDQEgktgfLYTPGDVDDCVEKL--ETLLADPELRERMGAAAREEVEK 417
 
Name Accession Description Interval E-value
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
 60-387 2.26e-47

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 165.63  E-value: 2.26e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175  60 RIVVPIREAAPGALSSSRAIRLVSEARGLGAMRRAITQWEPEVIHQHQATWSLP-AVGAARDTGAPLVVTVHGADAYrrl 138
Cdd:cd03798    56 EAVPPRDGRRLLPLKPRLRLLAPLRAPSLAKLLKRRRRGPPDLIHAHFAYPAGFaAALLARLYGVPYVVTEHGSDIN--- 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 139 grgpGAAWNDLNRRA---AFGGAHRLLAVSRYLADVALASGAQRRRLRVHYQGVDTAWWHPGagacDRGAGGAPGVPIVL 215
Cdd:cd03798   133 ----VFPPRSLLRKLlrwALRRAARVIAVSKALAEELVALGVPRDRVDVIPNGVDPARFQPE----DRGLGLPLDAFVIL 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 216 FVGALSHLKGVDDLVEASVRLHDAHPH-SLVLVGEGPLSSTLIA-HAPAH----VTVTGQLDREEVRDWMRRSHVLVLPT 289
Cdd:cd03798   205 FVGRLIPRKGIDLLLEAFARLAKARPDvVLLIVGDGPLREALRAlAEDLGlgdrVTFTGRLPHEQVPAYYRACDVFVLPS 284

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 290 kptrgRAEAAGLVLLEAQACGVPALAYATGGTPEMVAPGAS-VLTPGRTSTHLARTLGEAL--TWGDAERAERglacRRW 366
Cdd:cd03798   285 -----RHEGFGLVLLEAMACGLPVVATDVGGIPEVVGDPETgLLVPPGDADALAAALRRALaePYLRELGEAA----RAR 355

                         330       340
                  ....*....|....*....|.
gi 1992224175 367 VEENRSLATSADQLRAVYREV 387
Cdd:cd03798   356 VAERFSWVKAADRIAAAYRDV 376
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 88-385 5.15e-41

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 148.45  E-value: 5.15e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175  88 LGAMRRAITQWEPEVIHQHQATWSLPAVGAARDTGAPLVVTVHGADAYRRLGRGPGAAWnDLNRRAAFG-GAHRLLAVSR 166
Cdd:cd03801    71 LRELRPLLRLRKFDVVHAHGLLAALLAALLALLLGAPLVVTLHGAEPGRLLLLLAAERR-LLARAEALLrRADAVIAVSE 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 167 YLADVALASGAQ-RRRLRVHYQGVDTAWWHPGAgacDRGAGGAPGVPIVLFVGALSHLKGVDDLVEASVRLHDAHPH-SL 244
Cdd:cd03801   150 ALRDELRALGGIpPEKIVVIPNGVDLERFSPPL---RRKLGIPPDRPVLLFVGRLSPRKGVDLLLEALAKLLRRGPDvRL 226

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 245 VLVG-EGPLSS---TLIAHAPAHVTVTGQLDREEVRDWMRRSHVLVLPTkptrgRAEAAGLVLLEAQACGVPALAYATGG 320
Cdd:cd03801   227 VIVGgDGPLRAeleELELGLGDRVRFLGFVPDEELPALYAAADVFVLPS-----RYEGFGLVVLEAMAAGLPVVATDVGG 301

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1992224175 321 TPEMVAPGASVLTPGRTSTH-LARTLGEALTwGDAERAERGLACRRWVEENRSLATSADQLRAVYR 385
Cdd:cd03801   302 LPEVVEDGEGGLVVPPDDVEaLADALLRLLA-DPELRARLGRAARERVAERFSWERVAERLLDLYR 366
GT4-like cd05844
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar ...
 100-383 4.71e-38

glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to glycosyltransferase family 4 (GT4). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340860 [Multi-domain]  Cd Length: 365  Bit Score: 140.28  E-value: 4.71e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 100 PEVIHQHQATWSLPAVGAARDTGAPLVVTVHGADAYRR----LGRGPGAAWNDLNRRAAFGGAHRLLAVSRYLADVALAS 175
Cdd:cd05844    82 PALVHAHFGRDGVYALPLARALGVPLVVTFHGFDITTSrawlAASPGWPSQFQRHRRALQRPAALFVAVSGFIRDRLLAR 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 176 GAQRRRLRVHYQGVDTAWWHPGAGAcdrgaggaPGVPIVLFVGALSHLKGVDDLVEASVRLHDAHPH-SLVLVGEGPLSS 254
Cdd:cd05844   162 GLPAERIHVHYIGIDPAKFAPRDPA--------ERAPTILFVGRLVEKKGCDVLIEAFRRLAARHPTaRLVIAGDGPLRP 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 255 TL--IAHAPAHVTVTGQLDREEVRDWMRRSHVLVLPTKPTR-GRAEAAGLVLLEAQACGVPALAYATGGTPEMVAPG-AS 330
Cdd:cd05844   234 ALqaLAAALGRVRFLGALPHAEVQDWMRRAEIFCLPSVTAAsGDSEGLGIVLLEAAACGVPVVSSRHGGIPEAILDGeTG 313

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1992224175 331 VLTPGRTSTHLARTLgEALTWGDAERAERGLACRRWVEENRSLATSADQLRAV 383
Cdd:cd05844   314 FLVPEGDVDALADAL-QALLADRALADRMGGAARAFVCEQFDIRVQTAKLEAI 365
GT4_WavL-like cd03819
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ...
 41-372 2.04e-34

Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.


Pssm-ID: 340846 [Multi-domain]  Cd Length: 345  Bit Score: 130.17  E-value: 2.04e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175  41 AMPDLSWQAFTLAARVRDPRIVVPIREAAPGALsssraIRLVSEARGLGAMRRAITQWEPEVIHQHQATWSLPAVGAARD 120
Cdd:cd03819    23 ALAERGHRVLVVTAGGPLLPRLRQIGIGLPGLK-----VPLLRALLGNVRLARLIRRERIDLIHAHSRAPAWLGWLASRL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 121 TGAPLVVTVHGAdayRRLGRGPGAAWNDLNRRAAfggahRLLAVSRYLADVALAS-GAQRRRLRVHYQGVDTAWWHPGAG 199
Cdd:cd03819    98 TGVPLVTTVHGS---YLATYHPKDFALAVRARGD-----RVIAVSELVRDHLIEAlGVDPERIRVIPNGVDTDRFPPEAE 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 200 ACDRGAGGAP-GVPIVLFVGALSHLKGVDDLVEASVRLHDAHPHSLVLVGEGPLSSTLIAHAPAH-----VTVTGQldRE 273
Cdd:cd03819   170 AEERAQLGLPeGKPVVGYVGRLSPEKGWLLLVDAAAELKDEPDFRLLVAGDGPERDEIRRLVERLglrdrVTFTGF--RE 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 274 EVRDWMRRSHVLVLPtkptrGRAEAAGLVLLEAQACGVPALAYATGGTPEMVAPGA-SVLTPGRTSTHLARTLGEA-LTW 351
Cdd:cd03819   248 DVPAALAASDVVVLP-----SLHEEFGRVALEAMACGTPVVATDVGGAREIVVHGRtGLLVPPGDAEALADAIRAAkLLP 322

                         330       340
                  ....*....|....*....|.
gi 1992224175 352 GDAERAERGLACRRWVEENRS 372
Cdd:cd03819   323 EAREKLQAAAALTEAVRELLL 343
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 212-359 1.09e-28

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 109.67  E-value: 1.09e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 212 PIVLFVGALSHLKGVDDLVEASVRLHDAHPH-SLVLVGEGPLSSTLIAHA-----PAHVTVTGQLDREEVRDWMRRSHVL 285
Cdd:pfam00534   3 KIILFVGRLEPEKGLDLLIKAFALLKEKNPNlKLVIAGDGEEEKRLKKLAeklglGDNVIFLGFVSDEDLPELLKIADVF 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1992224175 286 VLPtkptrGRAEAAGLVLLEAQACGVPALAYATGGTPEMVAPGAS-VLTPGRTSTHLARTLGEALTwgDAERAER 359
Cdd:pfam00534  83 VLP-----SRYEGFGIVLLEAMACGLPVIASDVGGPPEVVKDGETgFLVKPNNAEALAEAIDKLLE--DEELRER 150
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
 74-370 2.20e-27

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 111.15  E-value: 2.20e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175  74 SSSRAIRLVSEARGLGAMRRAITQWEPEVIHQHQATWSLPAVGAARDTGAPLVV-TVHGadayrrLGRGPGAawNDLNR- 151
Cdd:cd03808    56 ILRRGINPLKDLKALFKLYKLLKKEKPDIVHCHTPKPGILGRLAARLAGVPKVIyTVHG------LGFVFTE--GKLLRl 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 152 ------RAAFGGAHRLLAVSRYLADVALASG--AQRRRLRVHYQGVDTAWWHPgagacdRGAGGAPGVPIVLFVGALSHL 223
Cdd:cd03808   128 lyllleKLALLFTDKVIFVNEDDRDLAIKKGiiKKKKTVLIPGSGVDLDRFQY------SPESLPSEKVVFLFVARLLKD 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 224 KGVDDLVEASVRLHDAHPH-SLVLVGEGPL---SSTLIA--HAPAHVTVTGQldREEVRDWMRRSHVLVLPTKptrgrAE 297
Cdd:cd03808   202 KGIDELIEAAKILKKKGPNvRFLLVGDGELenpSEILIEklGLEGRIEFLGF--RSDVPELLAESDVFVLPSY-----RE 274

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1992224175 298 AAGLVLLEAQACGVPALAYATGGTPEMVAPGAS-VLTPGRTSTHLARTLgEALTWGDAERAERGLACRRWVEEN 370
Cdd:cd03808   275 GLPRSLLEAMAAGRPVITTDVPGCRELVIDGVNgFLVPPGDVEALADAI-EKLIEDPELRKEMGEAARKRVEEK 347
GT4-like cd03814
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 90-385 4.24e-27

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340842 [Multi-domain]  Cd Length: 365  Bit Score: 110.46  E-value: 4.24e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175  90 AMRRAITQWEPEVIHQhqATWSLP---AVGAARDTGAPLVVTVHGA-DAY-RRLGRGPGAAWNDLNRRAAFGGAHRLLAV 164
Cdd:cd03814    75 RVRRLIKEFQPDIIHI--ATPGPLglaALRAARRLGLPVVTSYHTDfPEYlSYYTLGPLSWLAWAYLRWFHNPFDTTLVP 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 165 SRYLADVALASGAqrRRLRVHYQGVDTAWWHPGAG-ACDRGAGGAPGVPIVLFVGALSHLKGVDDLVEASVRLHDAHPHS 243
Cdd:cd03814   153 SPSIARELEGHGF--ERVRLWPRGVDTELFHPSRRdAALRRRLGPPGRPLLLYVGRLAPEKNLEALLDADLPLAASPPVR 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 244 LVLVGEGPLSSTLiAHAPAHVTVTGQLDREEVRDWMRRSHVLVLPtkptrGRAEAAGLVLLEAQACGVPALAYATGGTPE 323
Cdd:cd03814   231 LVVVGDGPARAEL-EARGPDVIFTGFLTGEELARAYASADVFVFP-----SRTETFGLVVLEAMASGLPVVAADAGGPRD 304

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1992224175 324 MVAPGAS-VLTPGRTSTHLARTLgEALTWGDAERAERGLAcRRWVEENRSLATSADQLRAVYR 385
Cdd:cd03814   305 IVRPGGTgALVEPGDAAAFAAAL-RALLEDPELRRRMAAR-ARAEAERYSWEAFLDNLLDYYA 365
GT4_ExpE7-like cd03823
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ...
 100-385 5.58e-27

glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).


Pssm-ID: 340850 [Multi-domain]  Cd Length: 357  Bit Score: 110.11  E-value: 5.58e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 100 PEVIH-QHQATWSLPAVGAARDTGAPLVVTVHgaDAYrrlgrgpgaaWNDLNRRAAFGGAHRLLAVSRYLADVALASGAQ 178
Cdd:cd03823    97 PDVVHtHNLSGLGASLLDAARDLGIPVVHTLH--DYW----------LLCPRQFLFKKGGDAVLAPSRFTANLHEANGLF 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 179 RRRLRVHYQGVDtawWHPGAGACDRGAGGAPGVpivLFVGALSHLKGVDDLVEAsVRLHDAHPHSLVLVGEGPLSSTLIA 258
Cdd:cd03823   165 SARISVIPNAVE---PDLAPPPRRRPGTERLRF---GYIGRLTEEKGIDLLVEA-FKRLPREDIELVIAGHGPLSDERQI 237

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 259 HAPAHVTVTGQLDREEVRDWMRRSHVLVLPTKptrgRAEAAGLVLLEAQACGVPALAYATGGTPEMVAPGAS--VLTPGR 336
Cdd:cd03823   238 EGGRRIAFLGRVPTDDIKDFYEKIDVLVVPSI----WPEPFGLVVREAIAAGLPVIASDLGGIAELIQPGVNglLFAPGD 313

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1992224175 337 TSThLARTLGEALTWGDAERAERGLAcrrwvEENRSLATSADQLRAVYR 385
Cdd:cd03823   314 AED-LAAAMRRLLTDPALLERLRAGA-----EPPRSTESQAEEYLKLYR 356
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
 100-374 8.41e-26

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 106.63  E-value: 8.41e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 100 PEVIHQ---HQATWSLPAVGAARdtGAPLVVTVHGADAYRRLGRgpgaaWNDLNRRAAFGGAHRLLAVSRYLADVALASG 176
Cdd:cd03807    80 PDVVHTwmyHADLIGGLAAKLAG--GVKVIWSVRSSNIPQRLTR-----LVRKLCLLLSKFSPATVANSSAVAEFHQEQG 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 177 AQRRRLRVHYQGVDTAWWHPGAGACDRGAGGAP---GVPIVLFVGALSHLKGVDDLVEASVRLHDAHPH-SLVLVGEGPL 252
Cdd:cd03807   153 YAKNKIVVIYNGIDLFKLSPDDASRARARRRLGlaeDRRVIGIVGRLHPVKDHSDLLRAAALLVETHPDlRLLLVGRGPE 232

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 253 SSTLIA-----HAPAHVTVTGQldREEVRDWMRRSHVLVLPTkptrgRAEAAGLVLLEAQACGVPALAYATGGTPEMVAP 327
Cdd:cd03807   233 RPNLERlllelGLEDRVHLLGE--RSDVPALLPAMDIFVLSS-----RTEGFPNALLEAMACGLPVVATDVGGAAELVDD 305

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1992224175 328 GASVLTPGRTSTHLARTLgEALTWGDAERAERGLACRRWVEENRSLA 374
Cdd:cd03807   306 GTGFLVPAGDPQALADAI-RALLEDPEKRARLGRAARERIANEFSID 351
GT4_WcaC-like cd03825
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ...
 99-387 3.41e-25

putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.


Pssm-ID: 340851 [Multi-domain]  Cd Length: 364  Bit Score: 105.11  E-value: 3.41e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175  99 EPEVIHQHQ--ATW-SLPAVGAARDtGAPLVVTVHGADAY--------------------RRLGRGPGAAWnDLNR---- 151
Cdd:cd03825    51 EADIIHLHWihGGYlSLKALFKLLR-RKPVVWTLHDMWPFtggchypmecegwktgcgncPNLNSYPPAKK-DLSRqlfr 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 152 --RAAFGGAH-RLLAVSRYLADVALASGA-QRRRLRVHYQGVDTAWWHPGAGACDRGAGGAPG-VPIVLFV--GALSHLK 224
Cdd:cd03825   129 rkREALAKKRlTIVAPSRWLADMVRRSPLlKGLPVVVIPNGIDTEIFAPVDKAKARKRLGIPQdKKVILFGaeSVTKPRK 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 225 GVDDLVEASVRLHDAHPHSLVLVGEGPLSstlIAHAPAHVTVTGQLDREE-VRDWMRRSHVLVLPTkptrgRAEAAGLVL 303
Cdd:cd03825   209 GFDELIEALKLLATKDDLLLVVFGKNDPQ---IVILPFDIISLGYIDDDEqLVDIYSAADLFVHPS-----LADNLPNTL 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 304 LEAQACGVPALAYATGGTPEMVAPG-ASVLTPGRTSTHLARTLGEALTwGDAERAERGLACRRWVEENRSLATSADQLRA 382
Cdd:cd03825   281 LEAMACGTPVVAFDTGGSPEIVQHGvTGYLVPPGDVQALAEAIEWLLA-NPKERESLGERARALAENHFDQRVQAQRYLE 359


                  ....*
gi 1992224175 383 VYREV 387
Cdd:cd03825   360 LYKDL 364
GT4_UGDG-like cd03817
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ...
 93-328 1.76e-23

UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.


Pssm-ID: 340844 [Multi-domain]  Cd Length: 372  Bit Score: 100.43  E-value: 1.76e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175  93 RAITQWEPEVIHQHqATWSLPAVG--AARDTGAPLVVTVHGA-DAYRRLGRGPGAAWNDLNRR--AAF-GGAHRLLAVSR 166
Cdd:cd03817    78 DRIKELGPDIIHTH-TPFSLGKLGlrIARKLKIPIVHTYHTMyEDYLHYIPKGKLLVKAVVRKlvRRFyNHTDAVIAPSE 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 167 YLADVALASGAQRRrLRVHYQGVDTAWWH-PGAGACDRGAGGAPGVPIVLFVGALSHLKGVDDLVEASVRLHDAHPHSLV 245
Cdd:cd03817   157 KIKDTLREYGVKGP-IEVIPNGIDLDKFEkPLNTEERRKLGLPPDEPILLYVGRLAKEKNIDFLLRAFAELKKEPNIKLV 235

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 246 LVGEGPLSSTLIAHA-----PAHVTVTGQLDREEVRDWMRRSHVLVLPTKptrgrAEAAGLVLLEAQACGVPALAYATGG 320
Cdd:cd03817   236 IVGDGPEREELKELArelglADKVIFTGFVPREELPEYYKAADLFVFAST-----TETQGLVYLEAMAAGLPVVAAKDPA 310


                  ....*...
gi 1992224175 321 TPEMVAPG 328
Cdd:cd03817   311 ASELVEDG 318
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
212-350 2.22e-21

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 89.11  E-value: 2.22e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 212 PIVLFVGALSH-LKGVDDLVEASVRLHDA-HPHSLVLVGEGPLSS--TLIAHAPAHVTVTGQldREEVRDWMRRSHVLVL 287
Cdd:pfam13692   2 PVILFVGRLHPnVKGVDYLLEAVPLLRKRdNDVRLVIVGDGPEEEleELAAGLEDRVIFTGF--VEDLAELLAAADVFVL 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1992224175 288 PTkptrgRAEAAGLVLLEAQACGVPALAYATGGTPEMVAPGASVLTPGRTSTHLARTLGEALT 350
Cdd:pfam13692  80 PS-----LYEGFGLKLLEAMAAGLPVVATDVGGIPELVDGENGLLVPPGDPEALAEAILRLLE 137
GT4_WbuB-like cd03794
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ...
 97-380 5.56e-21

Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.


Pssm-ID: 340825 [Multi-domain]  Cd Length: 391  Bit Score: 93.56  E-value: 5.56e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175  97 QWEPEVIHQHQ--ATWSLPAVGAARDTGAPLVVTVH------GADAYRRLGRGPGAAWNDLNRRAaFGGAHRLLAVSRYL 168
Cdd:cd03794    96 EERPDVIIAYSppITLGLAALLLKKLRGAPFILDVRdlwpesLIALGVLKKGSLLKLLKKLERKL-YRLADAIIVLSPGL 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 169 ADVALASGAQRRRLRVHYQGVDTAWWHPGAGACDRGAGGAPGVPIVLFVGALSHLKGVDDLVEASVRLHDAHPHSLVLVG 248
Cdd:cd03794   175 KEYLLRKGVPKEKIIVIPNWADLEEFKPPPKDELRKKLGLDDKFVVVYAGNIGKAQGLETLLEAAERLKRRPDIRFLFVG 254

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 249 EGPLSSTLIAHAPAH----VTVTGQLDREEVRDWMRRSHVLVLPTKPTRGRAEAAGLVLLEAQACGVPALAYATGGTPEM 324
Cdd:cd03794   255 DGDEKERLKELAKARgldnVTFLGRVPKEEVPELLSAADVGLVPLKDNPANRGSSPSKLFEYMAAGKPILASDDGGSDLA 334

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1992224175 325 VAPG--ASVLTPGRTSThLARTLgEALTWGDAERAERGLACRRWVEENRSLATSADQL 380
Cdd:cd03794   335 VEINgcGLVVEPGDPEA-LADAI-LELLDDPELRRAMGENGRELAEEKFSREKLADRL 390
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 86-328 1.27e-18

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 86.26  E-value: 1.27e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175  86 RGLGAMRRAITQWEPEVIHQHQATWSLpAVGAARDTGAPLVVTVHGADAYRRLGRGPGAAWNDLNRRAafggaHRLLAVS 165
Cdd:cd03811    70 KAILKLKRILKRAKPDVVISFLGFATY-IVAKLAAARSKVIAWIHSSLSKLYYLKKKLLLKLKLYKKA-----DKIVCVS 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 166 RYLADVALASGAQRR-RLRVHYQGVDTAwwHPGAGACDRGAGGAPGVPIVLFVGALSHLKGVDDLVEASVRLHDAHPHS- 243
Cdd:cd03811   144 KGIKEDLIRLGPSPPeKIEVIYNPIDID--RIRALAKEPILNEPEDGPVILAVGRLDPQKGHDLLIEAFAKLRKKYPDVk 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 244 LVLVGEGPLSSTLIA-----HAPAHVTVTGQldREEVRDWMRRSHVLVLPTkptrgRAEAAGLVLLEAQACGVPALAYAT 318
Cdd:cd03811   222 LVILGDGPLREELEKlakelGLAERVIFLGF--QSNPYPYLKKADLFVLSS-----RYEGFPNVLLEAMALGTPVVSTDC 294

                         250
                  ....*....|
gi 1992224175 319 GGTPEMVAPG 328
Cdd:cd03811   295 PGPREILDDG 304
GT4_BshA-like cd04962
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ...
 101-387 2.20e-18

N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340859 [Multi-domain]  Cd Length: 370  Bit Score: 85.48  E-value: 2.20e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 101 EVIHQHQAT-WSLPAVGAARDTGA--PLVVTVHGADAyRRLGRGPgaAWNDLNRrAAFGGAHRLLAVSRYLADVALASGA 177
Cdd:cd04962    86 DVLHAHYAIpHASCAYLAREILGEkiPIVTTLHGTDI-TLVGYDP--SLQPAVR-FSINKSDRVTAVSSSLRQETYELFD 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 178 QRRRLRVHYQGVDTAWWHP-GAGACDRGAGGAPGVPIVLFVGALSHLKGVDDLVEASVRLHDAHPHSLVLVGEGPLSSTL 256
Cdd:cd04962   162 VDKDIEVIHNFIDEDVFKRkPAGALKRRLLAPPDEKVVIHVSNFRPVKRIDDVVRVFARVRRKIPAKLLLVGDGPERVPA 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 257 IAHAPA-----HVTVTGQLDreEVRDWMRRSHVLVLPTKptrgrAEAAGLVLLEAQACGVPALAYATGGTPEMVAPGAS- 330
Cdd:cd04962   242 EELARElgvedRVLFLGKQD--DVEELLSIADLFLLPSE-----KESFGLAALEAMACGVPVVSSNAGGIPEVVKHGETg 314

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 331 -VLTPG--RTSTHLARTLGEaltwGDAERAERGLACRRWVEENRSLATSADQLRAVYREV 387
Cdd:cd04962   315 fLSDVGdvDAMAKSALSILE----DDELYNRMGRAARKRAAERFDPERIVPQYEAYYRRL 370
GT4_WfcD-like cd03795
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ...
 208-370 7.93e-18

Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340826 [Multi-domain]  Cd Length: 355  Bit Score: 83.86  E-value: 7.93e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 208 APGVPIVLFVGALSHLKGVDDLVEAsVRLHDAhphSLVLVGEGPLSSTLIAHAPAH----VTVTGQLDREEVRDWMRRSH 283
Cdd:cd03795   188 KKGKKIFLFIGRLVYYKGLDYLIEA-AQYLNY---PIVIGGEGPLKPDLEAQIELNlldnVKFLGRVDDEEKVIYLHLCD 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 284 VLVLPTKPtrgRAEAAGLVLLEAQACGVPALAYATG-GTPEMVAPGAS--VLTPGRtsthlARTLGEALT--WGDAERAE 358
Cdd:cd03795   264 VFVFPSVL---RSEAFGIVLLEAMMCGKPVISTNIGtGVPYVNNNGETglVVPPKD-----PDALAEAIDklLSDEELRE 335

                         170
                  ....*....|...
gi 1992224175 359 R-GLACRRWVEEN 370
Cdd:cd03795   336 SyGENAKKRFEEL 348
GT4_sucrose_synthase cd03800
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ...
 100-382 1.55e-17

sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.


Pssm-ID: 340830 [Multi-domain]  Cd Length: 398  Bit Score: 83.44  E-value: 1.55e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 100 PEVIHQHQATWSLPAVGAARDTGAPLVVTVH--GADAYRRLGrgpGAAWNDLNRRaaFGGAHRLLAVsrylADVALASGA 177
Cdd:cd03800   102 YDLIHSHYWDSGLVGALLARRLGVPLVHTFHslGRVKYRHLG---AQDTYHPSLR--ITAEEQILEA----ADRVIASTP 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 178 QRRR-LRVHYQ-----------GVDTAWWHPG--AGACDRGAGGAPGVPIVLFVGALSHLKGVDDLVEA-SVRLHDAHPH 242
Cdd:cd03800   173 QEADeLISLYGadpsrinvvppGVDLERFFPVdrAEARRARLLLPPDKPVVLALGRLDPRKGIDTLVRAfAQLPELRELA 252

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 243 SLVLVG--EGPLSS---------TLIAHAPAHVTVTGQLDREEVRDWMRRSHVLVLPTkptrgRAEAAGLVLLEAQACGV 311
Cdd:cd03800   253 NLVLVGgpSDDPLSmdreelaelAEELGLIDRVRFPGRVSRDDLPELYRAADVFVVPS-----LYEPFGLTAIEAMACGT 327

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1992224175 312 PALAYATGGTPEMVAPGAS-VLTPGRTSTHLARTLGEALTwgDAERAER-GLACRRWVEENRSLATSADQLRA 382
Cdd:cd03800   328 PVVATAVGGLQDIVRDGRTgLLVDPHDPEALAAALRRLLD--DPALWQRlSRAGLERARAHYTWESVADQLLT 398
GT4_AmsK-like cd03799
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases ...
 88-380 3.24e-17

Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases found specifically in certain bacteria. AmsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor.


Pssm-ID: 340829 [Multi-domain]  Cd Length: 350  Bit Score: 82.11  E-value: 3.24e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175  88 LGAMRRAITQWEPEVIHQHQATWSLPAVGAARDTG--APLVVTVHGADAYRRLGRGPGAAWNDLnrraaFGGAHRLLAVS 165
Cdd:cd03799    59 LYAIVGLNKKGAYDIIHCQFGPLGALGALLRRLKVlkGKLVTSFRGYDISMYVILEGNKVYPQL-----FAQGDLFLPNC 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 166 RYLADVALASGAQRRRLRVHYQGVDTA------WWHPgAGACDRgaggapgvpiVLFVGALSHLKGVDDLVEASVRLHDA 239
Cdd:cd03799   134 ELFKHRLIALGCDEKKIIVHRSGIDCNkfrfkpRYLP-LDGKIR----------ILTVGRLTEKKGLEYAIEAVAKLAQK 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 240 HPH-SLVLVGEGPLSS---TLIA--HAPAHVTVTGQLDREEVRDWMRRSHVLVLPTKPTR-GRAEAAGLVLLEAQACGVP 312
Cdd:cd03799   203 YPNiEYQIIGDGDLKEqlqQLIQelNIGDCVKLLGWKPQEEIIEILDEADIFIAPSVTAAdGDQDGPPNTLKEAMAMGLP 282

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1992224175 313 ALAYATGGTPEMVAPGAS-VLTPGRTSTHLARTLGEaLTWGDAERAERGLACRRWVEENRSLATSADQL 380
Cdd:cd03799   283 VISTEHGGIPELVEDGVSgFLVPERDAEAIAEKLTY-LIEHPAIWPEMGKAGRARVEEEYDINKLNDEL 350
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 119-382 1.02e-16

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 80.49  E-value: 1.02e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 119 RDTGAPLVVTVHgaDA---YRRLGRGPGAAW--NDLNRRAAFGGAHrLLAVSRYLA-DVALASGAQRRRLRVHYQGVDTA 192
Cdd:cd03809    98 LLKGCPQVVTIH--DLiplRYPEFFPKRFRLyyRLLLPISLRRADA-IITVSEATRdDIIKFYGVPPEKIVVIPLGVDPS 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 193 WWHPGAGACDRGAGGAPGvPIVLFVGALSHLKGVDDLVEASVRLHDAHP-HSLVLVGEGPLSS----TLIAHAPA--HVT 265
Cdd:cd03809   175 FFPPESAAVLIAKYLLPE-PYFLYVGTLEPRKNHERLLKAFALLKKQGGdLKLVIVGGKGWEDeellDLVKKLGLggRVR 253

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 266 VTGQLDREEVRDWMRRSHVLVLPTkptrgRAEAAGLVLLEAQACGVPALAYATGGTPEmVAPGASVLTPGRTSTHLARTL 345
Cdd:cd03809   254 FLGYVSDEDLPALYRGARAFVFPS-----LYEGFGLPVLEAMACGTPVIASNISVLPE-VAGDAALYFDPLDPESIADAI 327

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1992224175 346 GEALTWGDAERAERGLACRRWveENRSLATSADQLRA 382
Cdd:cd03809   328 LRLLEDPSLREELIRKGLERA--KKFSWEKTAEKTLE 362
GT4_Bme6-like cd03821
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ...
 77-381 1.19e-16

Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.


Pssm-ID: 340848 [Multi-domain]  Cd Length: 377  Bit Score: 80.49  E-value: 1.19e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175  77 RAIRLVSEARGLGAMRRAITQW------EPEVIHQHqATW---SLPAVGAARDTGAPLVVTVHGA-DAYRRLGRGP--GA 144
Cdd:cd03821    62 ASIPLLRQGAGRTDFSPGLPNWlrrnlrEYDVVHIH-GVWtytSLAACKLARRRGIPYVVSPHGMlDPWALQQKHWkkRI 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 145 AWNDLNRRAaFGGAHRLLAVSRYLADVALASGAQRRRLRVHYqGVDTAWWHPGaGACDRGAGGAPGVPIVLFVGALSHLK 224
Cdd:cd03821   141 ALHLIERRN-LNNAALVHFTSEQEADELRRFGLEPPIAVIPN-GVDIPEFDPG-LRDRRKHNGLEDRRIILFLGRIHPKK 217

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 225 GVDDLVEASVRLHDAHPH-SLVLVGEGPLSSTLIAHAPA------HVTVTGQLDREEVRDWMRRSHVLVLPTkptrgRAE 297
Cdd:cd03821   218 GLDLLIRAARKLAEQGRDwHLVIAGPDDGAYPAFLQLQSslglgdRVTFTGPLYGEAKWALYASADLFVLPS-----YSE 292

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 298 AAGLVLLEAQACGVPALAYATGGTPEMVAPGASVLTPGRTSThLARTLGEALTwGDAERAERGLACRR--WVEENRSLAT 375
Cdd:cd03821   293 NFGNVVAEALACGLPVVITDKCGLSELVEAGCGVVVDPNVSS-LAEALAEALR-DPADRKRLGEMARRarQVEENFSWEA 370


                  ....*.
gi 1992224175 376 SADQLR 381
Cdd:cd03821   371 VAGQLG 376
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 278-389 1.69e-16

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 75.03  E-value: 1.69e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 278 WMRRSHVLVLPTkptrgRAEAAGLVLLEAQACGVPALAYATGGTPEMVAPGAS-VLTPGRTSTHLARTLGEALTWgDAER 356
Cdd:COG0438    17 LLAAADVFVLPS-----RSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETgLLVPPGDPEALAEAILRLLED-PELR 90

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1992224175 357 AERGLACRRWVEENRSLATSADQLRAVYREVSR 389
Cdd:COG0438    91 RRLGEAARERAEERFSWEAIAERLLALYEELLA 123
PLN02871 PLN02871
UDP-sulfoquinovose:DAG sulfoquinovosyltransferase
 158-369 2.29e-16

UDP-sulfoquinovose:DAG sulfoquinovosyltransferase


Pssm-ID: 215469 [Multi-domain]  Cd Length: 465  Bit Score: 80.53  E-value: 2.29e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 158 AHRLLAVSRYLADVALASGAQ-RRRLRVHYQGVDTAWWHP---GAGACDRGAGGAPGVPIVLFVGALSHLKGVDDLVEAS 233
Cdd:PLN02871  206 ADLTLVTSPALGKELEAAGVTaANRIRVWNKGVDSESFHPrfrSEEMRARLSGGEPEKPLIVYVGRLGAEKNLDFLKRVM 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 234 VRLHDAhphSLVLVGEGPLSSTLIAH-APAHVTVTGQLDREEVRDWMRRSHVLVLPTKptrgrAEAAGLVLLEAQACGVP 312
Cdd:PLN02871  286 ERLPGA---RLAFVGDGPYREELEKMfAGTPTVFTGMLQGDELSQAYASGDVFVMPSE-----SETLGFVVLEAMASGVP 357

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1992224175 313 ALAYATGGTPEMVAPGAS-----VLTPGRTSTHLARTlgEALTWGDAERAERGLACRRWVEE 369
Cdd:PLN02871  358 VVAARAGGIPDIIPPDQEgktgfLYTPGDVDDCVEKL--ETLLADPELRERMGAAAREEVEK 417
GT4_WbaZ-like cd03804
mannosyltransferase WbaZ and similar proteins; This family is most closely related to the GT4 ...
 164-328 1.51e-14

mannosyltransferase WbaZ and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbaZ in Salmonella enterica has been shown to possess mannosyltransferase activity.


Pssm-ID: 340833 [Multi-domain]  Cd Length: 356  Bit Score: 74.24  E-value: 1.51e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 164 VSRYLADvalaSGAQRRRLRVHYqGVDTAWWHPGAgACDRGAGGAPGVPIVLFVGALSHLKGVDDLVEASVRLhdahPHS 243
Cdd:cd03804   158 VDLFIAN----SQFVARRIKKFY-GRESTVIYPPV-DTDAFAPAADKEDYYLTASRLVPYKRIDLAVEAFNEL----PKR 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 244 LVLVGEGPLSSTLIAHAPAHVTVTGQLDREEVRDWMRRSHVLVLPTKptrgraEAAGLVLLEAQACGVPALAYATGGTPE 323
Cdd:cd03804   228 LVVIGDGPDLDRLRAMASPNVEFLGYQPDEVLKELLSKARAFVFAAE------EDFGIVPVEAQACGTPVIAFGKGGALE 301


                  ....*
gi 1992224175 324 MVAPG 328
Cdd:cd03804   302 TVRPG 306
GT4_AviGT4-like cd03802
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is ...
 63-387 2.85e-14

UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.


Pssm-ID: 340832 [Multi-domain]  Cd Length: 333  Bit Score: 73.09  E-value: 2.85e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175  63 VPIREAAPGALSSSRAIRLVSEARGLGAMRRAITQWEPEVIHQHQATWSLPAvgaARDTGAPLVVTVHGADayrrlgRGP 142
Cdd:cd03802    50 APLVAVIPRALRLDPIPQESKLAELLEALEVQLRASDFDVIHNHSYDWLPPF---APLIGTPFVTTLHGPS------IPP 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 143 GAAWNDLNRRAAFggahrlLAVSRYLADvalASGAQRRRLRVHYqGVDTAWWHPgagaCDRGAggapgvPIVLFVGALSH 222
Cdd:cd03802   121 SLAIYAAEPPVNY------VSISDAQRA---ATPPIDYLTVVHN-GLDPADYRF----QPDPE------DYLAFLGRIAP 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 223 LKGVDDLVEASVRLhDAHPHSLVLVGEGPLSSTLIAHAP-AHVTVTGQLDREEVRDWMRRSHVLVLPTKPTrgraEAAGL 301
Cdd:cd03802   181 EKGLEDAIRVARRA-GLPLKIAGKVRDEDYFYYLQEPLPgPRIEFIGEVGHDEKQELLGGARALLFPINWD----EPFGL 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 302 VLLEAQACGVPALAYATGGTPEmvapgasVLTPGRTStHLARTLGEAL-TWGDAERAERgLACRRWVEENRSLATSADQL 380
Cdd:cd03802   256 VMIEAMACGTPVIAYRRGGLPE-------VIQHGETG-FLVDSVEEMAeAIANIDRIDR-AACRRYAEDRFSAARMADRY 326


                  ....*..
gi 1992224175 381 RAVYREV 387
Cdd:cd03802   327 EALYRKV 333
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 170-332 5.20e-12

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 65.12  E-value: 5.20e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 170 DVALASGAQRRRLRVHYQGVDTAWWHPGAGACDRGAGGAPGVPIV----LFVGALSHLKGVDDLVEASVRLHDAHPH-SL 244
Cdd:cd01635    65 AAALAALLAARLLGIPIVVTVHGPDSLESTRSELLALARLLVSLPladkVSVGRLVPEKGIDLLLEALALLKARLPDlVL 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 245 VLVGEGPLSSTLIAHAPA-----HVTVTGQLDREEVRDWMRR-SHVLVLPTkptrgRAEAAGLVLLEAQACGVPALAYAT 318
Cdd:cd01635   145 VLVGGGGEREEEEALAAAlglleRVVIIGGLVDDEVLELLLAaADVFVLPS-----RSEGFGLVLLEAMAAGKPVIATDV 219

                         170
                  ....*....|....
gi 1992224175 319 GGTPEMVAPGASVL 332
Cdd:cd01635   220 GGIPEFVVDGENGL 233
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
 213-347 2.12e-11

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 64.57  E-value: 2.12e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 213 IVLFVGALSHLKGVDDLVEASVRLHDAHPH-SLVLVGEGPLSSTLIAHAPAHvtvtGQLDR-------EEVRDWMRRSHV 284
Cdd:cd03820   183 RILAVGRLTYQKGFDLLIEAWALIAKKHPDwKLRIYGDGPEREELEKLIDKL----GLEDRvkllgptKNIAEEYANSSI 258

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1992224175 285 LVLPTkptrgRAEAAGLVLLEAQACGVPALAYA-TGGTPEMVAPGAS-VLTPGRTSTHLARTLGE 347
Cdd:cd03820   259 FVLSS-----RYEGFPMVLLEAMAYGLPIISFDcPTGPSEIIEDGENgLLVPNGDVDALAEALLR 318
Glyco_transf_4 pfam13439
Glycosyltransferase Family 4;
90-192 1.44e-08

Glycosyltransferase Family 4;


Pssm-ID: 463877 [Multi-domain]  Cd Length: 169  Bit Score: 53.69  E-value: 1.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175  90 AMRRAITQWEPEVIHQHQA-TWSLPAVGAARDTGAPLVVTVHGADAYRRLGRGPGAAWNDLNR---RAAFGGAHRLLAVS 165
Cdd:pfam13439  62 RLRRLLRRERPDVVHAHSPfPLGLAALAARLRLGIPLVVTYHGLFPDYKRLGARLSPLRRLLRrleRRLLRRADRVIAVS 141

                          90       100
                  ....*....|....*....|....*...
gi 1992224175 166 RYLADVALAS-GAQRRRLRVHYQGVDTA 192
Cdd:pfam13439 142 EAVADELRRLyGVPPEKIRVIPNGVDLE 169
GT4-like cd03813
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 111-385 2.51e-06

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340841 [Multi-domain]  Cd Length: 474  Bit Score: 49.26  E-value: 2.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 111 SLPAVGAARDTGAPLVVTVHG----------------ADAYRRLgrgpgaaWNDLNR---RAAFGGAHRLLAVSRYLADV 171
Cdd:cd03813   186 GLLGALARHRRGIPFLLTEHGiytrerkieilqstwiMGYIKKL-------WIRFFErlgKLAYQQADKIISLYEGNRRR 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 172 ALASGAQRRRLRVHYQGVDTAWWHPGAGACDRGAGgapgvPIVLFVGALSHLKGVDDLVEASVRLHDAHPHS-LVLVG-- 248
Cdd:cd03813   259 QIRLGADPDKTRVIPNGIDIQRFAPAREERPEKEP-----PVVGLVGRVVPIKDVKTFIRAFKLVRRAMPDAeGWLIGpe 333

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 249 -EGPL----SSTLIAHA--PAHVTVTGQLDREEVrdwMRRSHVLVLPTKptrgrAEAAGLVLLEAQACGVPALAYATGGT 321
Cdd:cd03813   334 dEDPEyaqeCKRLVASLglENKVKFLGFQNIKEY---YPKLGLLVLTSI-----SEGQPLVILEAMASGVPVVATDVGSC 405

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1992224175 322 PEMV-----APG-ASVLTPGRTsthlARTLGEALTW--GDAERAER-GLACRRWVEENRSLATSADQLRAVYR 385
Cdd:cd03813   406 RELIygaddALGqAGLVVPPAD----PEALAEALIKllRDPELRQAfGEAGRKRVEKYYTLEGMIDSYRKLYL 474
GT4_WbdM_like cd04951
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most ...
 213-356 3.25e-06

LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340857 [Multi-domain]  Cd Length: 360  Bit Score: 48.60  E-value: 3.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 213 IVLFVGALSHLKGVDDLVEASVRLHDAHPH-SLVLVGEGPLSSTLI-----AHAPAHVTVTGQLDreEVRDWMRRSHVLV 286
Cdd:cd04951   190 VILNVGRLTEAKDYPNLLLAISELILSKNDfKLLIAGDGPLRNELErlicnLNLVDRVILLGQIS--NISEYYNAADLFV 267

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 287 LPTkptrgRAEAAGLVLLEAQACGVPALAYATGGTPEMVAPgASVLTPGRTSTHLARTLGEALTWGDAER 356
Cdd:cd04951   268 LSS-----EWEGFGLVVAEAMACERPVVATDAGGVAEVVGD-HNYVVPVSDPQLLAEKIKEIFDMSDEER 331
Glyco_trans_4_4 pfam13579
Glycosyl transferase 4-like domain;
77-184 5.51e-06

Glycosyl transferase 4-like domain;


Pssm-ID: 433325 [Multi-domain]  Cd Length: 158  Bit Score: 45.85  E-value: 5.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175  77 RAIRLVSEARGLGAMRRAITQWEPEVIHQHQATWSLPAVGAARDTGAPLVVTVHGADayRRLGRGPGAAWNDLNRRAAFG 156
Cdd:pfam13579  49 PRPSPLADLAALRRLRRLLRAERPDVVHAHSPTAGLAARLARRRRGVPLVVTVHGLA--LDYGSGWKRRLARALERRLLR 126

                          90       100
                  ....*....|....*....|....*...
gi 1992224175 157 GAHRLLAVSRYLADVALASGAQRRRLRV 184
Cdd:pfam13579 127 RADAVVVVSEAEAELLRALGVPAARVVV 154
GT4_mannosyltransferase-like cd03822
mannosyltransferases of glycosyltransferase family 4 and similar proteins; This family is most ...
 57-385 7.59e-06

mannosyltransferases of glycosyltransferase family 4 and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides.


Pssm-ID: 340849 [Multi-domain]  Cd Length: 370  Bit Score: 47.38  E-value: 7.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175  57 RDPRIVVPIREAAPGALSSSRAIRLVSEARGLGAMRRA--ITQWE-PEVIH-QHQ-----ATWSLPAVGAARDTGAPLVV 127
Cdd:cd03822    30 GPVVIVVIVSPQDEILKDDDFEVPNEIKSWNSNEYFRLldHLNFKkPDVVHiQHEfgifgGKYGLYALGLLLHLRIPVIT 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 128 TVHGADAYRRLGrgpgaawnDLNRRAAFGgahrllaVSRYLADVALASGAqRRRLRVHYQGVDTAWWH---------PGA 198
Cdd:cd03822   110 TLHTVLDLSDPG--------KQALKVLFR-------IATLSERVVVMAPI-SRFLLVRIKLIPAVNIEviphgvpevPQD 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 199 GACDRGAGGAP-GVPIVLFVGALSHLKGVDDLVEASVRLHDAHPH-SLVLVGE---GPLSSTLIAHAPA---------HV 264
Cdd:cd03822   174 PTTALKRLLLPeGKKVILTFGFIGPGKGLEILLEALPELKAEFPDvRLVIAGElhpSLARYEGERYRKAaieelglqdHV 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 265 T-VTGQLDREEVRDWMRRSHVLVLptkPTRGRAEAAGLVLLEAQACGVPALAYATGGTPEMVAPGASVLTPGRTSTHLAR 343
Cdd:cd03822   254 DfHNNFLPEEEVPRYISAADVVVL---PYLNTEQSSSGTLSYAIACGKPVISTPLRHAEELLADGRGVLVPFDDPSAIAE 330

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1992224175 344 TLGEALTWGD-----AERAERgLACRRWVEEnrslatSADQLRAVYR 385
Cdd:cd03822   331 AILRLLEDDErrqaiAERAYA-YARAMTWES------IADRYLRLFN 370
GT4_ExpC-like cd03818
Rhizobium meliloti ExpC and similar proteins; This family is most closely related to the GT4 ...
 179-328 1.14e-05

Rhizobium meliloti ExpC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II).


Pssm-ID: 340845 [Multi-domain]  Cd Length: 396  Bit Score: 46.97  E-value: 1.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 179 RRRLRVHYQGVDTAWWHPGAGA---CDRGAGGAPGVPIVLFVG-ALSHLKGVDDLVEASVRLHDAHPHSLVLV------- 247
Cdd:cd03818   178 RDRISVIHDGVDTDRLAPDPAArlrLLNGTELKAGDPVITYVArNLEPYRGFHVFMRALPRIQARRPDARVVVvggdgvs 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 248 --GEGPLSSTLIAHA-------PAHVTVTGQLDREEVRDWMRRSHVLVLPTKPTrgraeAAGLVLLEAQACGVPALAYAT 318
Cdd:cd03818   258 ygSPPPDGGSWKQKMlaelgvdLERVHFVGKVPYDQYVRLLQLSDAHVYLTYPF-----VLSWSLLEAMACGCPVIGSDT 332

                         170
                  ....*....|
gi 1992224175 319 GGTPEMVAPG 328
Cdd:cd03818   333 APVREVIRDG 342
GT4_CapH-like cd03812
capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This ...
 217-314 6.16e-05

capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1).


Pssm-ID: 340840 [Multi-domain]  Cd Length: 357  Bit Score: 44.59  E-value: 6.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 217 VGALSHLKGVDDLVEASVRLHDAHPHS-LVLVGEGPLSSTLIAHAPA-----HVTVTGQldREEVRDWMRRSHVLVLPTK 290
Cdd:cd03812   197 VGRFNEQKNHSFLIDIFEELKKKNPNVkLVLVGEGELKEKIKEKVKElgledKVIFLGF--RNDVSEILSAMDVFLFPSL 274

                          90       100
                  ....*....|....*....|....
gi 1992224175 291 ptrgrAEAAGLVLLEAQACGVPAL 314
Cdd:cd03812   275 -----YEGLPLVAVEAQASGLPCL 293
GT4_PIG-A-like cd03796
phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This ...
 213-323 1.50e-04

phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Phosphatidylinositol glycan-class A (PIG-A), an X-linked gene in humans, is necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, a very early intermediate in glycosyl phosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is an important cellular structure that facilitates the attachment of many proteins to cell surfaces. Somatic mutations in PIG-A have been associated with Paroxysmal Nocturnal Hemoglobinuria (PNH), an acquired hematological disorder.


Pssm-ID: 340827 [Multi-domain]  Cd Length: 398  Bit Score: 43.38  E-value: 1.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 213 IVLFVGALSHLKGVDDLVEASVRLHDAHPH-SLVLVGEGPLSSTLIAHAPAH-----VTVTGQLDREEVRDWMRRSHVLv 286
Cdd:cd03796   195 TIVVISRLVYRKGIDLLVGIIPRICKKHPNvRFIIGGDGPKRIELEEMREKYqlqdrVELLGAVPHEEVRDVLVQGHIF- 273

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1992224175 287 LPTKPTrgraEAAGLVLLEAQACGVPALAYATGGTPE 323
Cdd:cd03796   274 LNTSLT----EAFCIAIVEAASCGLLVVSTRVGGIPE 306
GT4_AmsK-like cd04946
amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most ...
 223-334 6.82e-04

amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmsK is involved in the biosynthesis of amylovoran, which functions as a virulence factor. It functions as a glycosyl transferase which transfers galactose from UDP-galactose to a lipid-linked amylovoran-subunit precursor. The members of this family are found mainly in bacteria and Archaea.


Pssm-ID: 340854 [Multi-domain]  Cd Length: 401  Bit Score: 41.29  E-value: 6.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 223 LKGVDDLVEASVRLHDAHPH---SLVLVGEGPLS---STLIAHAPAHVTV--TGQLDREEVRDWMRRS--HVLVlptkpT 292
Cdd:cd04946   236 VKRIDLIIETLNSLCVAHPSiciSWTHIGGGPLKerlEKLAENKLENVKVnfTGEVSNKEVKQLYKENdvDVFV-----N 310

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1992224175 293 RGRAEAAGLVLLEAQACGVPALAYATGGTPEMVAPGASVLTP 334
Cdd:cd04946   311 VSESEGIPVSIMEAISFGIPVIATNVGGTREIVENETNGLLL 352
GT28_Beta-DGS-like cd17507
beta-diglucosyldiacylglycerol synthase and similar proteins; beta-diglucosyldiacylglycerol ...
 209-316 1.96e-03

beta-diglucosyldiacylglycerol synthase and similar proteins; beta-diglucosyldiacylglycerol synthase (processive diacylglycerol beta-glucosyltransferase EC 2.4.1.315) is involved in the biosynthesis of both the bilayer- and non-bilayer-forming membrane glucolipids. This family of glycosyltransferases also contains plant major galactolipid synthase (chloroplastic monogalactosyldiacylglycerol synthase 1 EC 2.4.1.46). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340861 [Multi-domain]  Cd Length: 364  Bit Score: 39.99  E-value: 1.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 209 PGVPIVLFVGALSHLKGVDDLVEASVRlHDAHPHSLVLVGE-GPLSSTLiAHAPA---HVTVTGQldREEVRDWMRRSHV 284
Cdd:cd17507   195 PDKPTVLLMGGGGGMGPVKETVEALLD-SLRAGQVLVVCGKnKKLYEKL-SGLEEdyiNVRVLGY--VDDMNELMAASDL 270

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1992224175 285 LVlpTKPtrgraeaAGLVLLEAQACGVPALAY 316
Cdd:cd17507   271 VI--TKP-------GGLTISEALARGLPVIIY 293
PRK15490 PRK15490
Vi polysaccharide biosynthesis glycosyltransferase TviE;
230-330 3.60e-03

Vi polysaccharide biosynthesis glycosyltransferase TviE;


Pssm-ID: 185387 [Multi-domain]  Cd Length: 578  Bit Score: 39.30  E-value: 3.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 230 VEASVRLHDAHPHS-LVLVGEGPLSstliAHAPAHVTVTGQLDR-------EEVRDWMRRSHVLVLPTkptrgRAEAAGL 301
Cdd:PRK15490  417 IDFAARYLQHHPATrFVLVGDGDLR----AEAQKRAEQLGILERilfvgasRDVGYWLQKMNVFILFS-----RYEGLPN 487

                          90       100
                  ....*....|....*....|....*....
gi 1992224175 302 VLLEAQACGVPALAYATGGTPEMVAPGAS 330
Cdd:PRK15490  488 VLIEAQMVGVPVISTPAGGSAECFIEGVS 516
PRK15179 PRK15179
Vi polysaccharide biosynthesis protein TviE; Provisional
 230-373 7.51e-03

Vi polysaccharide biosynthesis protein TviE; Provisional


Pssm-ID: 185101 [Multi-domain]  Cd Length: 694  Bit Score: 38.48  E-value: 7.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1992224175 230 VEASVRLHDAHPHS-LVLVGEGPLSSTLIAHAPA-----HVTVTGQLDReeVRDWMRRSHVLVLPTkptrgRAEAAGLVL 303
Cdd:PRK15179  536 VEAAQRFAASHPKVrFIMVGGGPLLESVREFAQRlgmgeRILFTGLSRR--VGYWLTQFNAFLLLS-----RFEGLPNVL 608

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1992224175 304 LEAQACGVPALAYATGGTPEMVAPGASVLT-PGRTSTHlaRTLGEAL-TWGDAERAERGLA--CRRWVEENRSL 373
Cdd:PRK15179  609 IEAQFSGVPVVTTLAGGAGEAVQEGVTGLTlPADTVTA--PDVAEALaRIHDMCAADPGIArkAADWASARFSL 680
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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