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Conserved domains on  [gi|1937413369|ref|WP_195950569|]
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UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase [Streptococcus salivarius]

Protein Classification

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase( domain architecture ID 11487059)

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase catalyzes the addition of L-lysine to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK14022 PRK14022
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;
2-481 0e+00

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;


:

Pssm-ID: 237588 [Multi-domain]  Cd Length: 481  Bit Score: 888.62  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369   2 ITIEQVLEVLKKDHNFRDIIDQDNYYYSWTEVTFDHLSYDSRDVTPSSLFFAKGAAFKPEFLENAVKAGLSFYVAEKDYQ 81
Cdd:PRK14022    1 ITIETLLDILKKDHNFREIIDQDHYHYNYSGVQFDDISYDSRTADEGTLFFAKGAYFKHKFLQNAITQGLKLYVSEKDYE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369  82 VGIPAIIVSDIKQAMSLVAQAFYQYPQDKLKLLAFTGTKGKTTAAYFAFNILKQSHKPAMLSTMNTTLDGKNFFKSTLTT 161
Cdd:PRK14022   81 VGIPQVIVPDIKKAMSLIAMEFYDNPQHKLKLLAFTGTKGKTTAAYFAYHILKQLHKPAMLSTMNTTLDGETFFKSALTT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 162 PESLDLFRMMAEAVANGMTHLIMEVSSQAYLTKRVYGLTFDVGVFLNISPDHIGPIEHPTFEDYFYHKRLLLENSRVVIV 241
Cdd:PRK14022  161 PESLDLFKMMAEAVDNGMTHLIMEVSSQAYLVGRVYGLTFDVGVFLNITPDHIGPIEHPTFEDYFYHKRLLMENSKAVVV 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 242 NSGMDHFDFIAEEVADKEHDFYGKNSDNAVKHGSGFSFKASGKLAGDYDIQLIGDFNQDNAMAAGLACLRLGASLQDIKE 321
Cdd:PRK14022  241 NSDMDHFSELLEQVTPQEHDFYGIDSENQIMASNAFSFEATGKLAGTYDIQLIGKFNQENAMAAGLACLRLGASLEDIQK 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 322 GIAQTSVPGRMEVLTQTNGAKIFVDYAHNGDSLDKLLQVVTSHQDGRISLILGAPGNKGESRRKDFGHVLNTYPDVDIIL 401
Cdd:PRK14022  321 GIAQTPVPGRMEVLTQSNGAKVFIDYAHNGDSLNKLIDVVEEHQKGKLILLLGAAGNKGESRRPDFGRVANRHPYLQVIL 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 402 TADDPNKEDPLAICQEIASHISREVRIIVDREKAIKTAMSETIDSKDAVVIAGKGADAFQIVNGKRDNYAGDIEVAKKYL 481
Cdd:PRK14022  401 TADDPNNEDPKMITQEIASHITHPVEIIDDRAEAIKHAMSITEGPGDAVIIAGKGADAYQIVPGHRDDYIGDEAAAKKYL 480
 
Name Accession Description Interval E-value
PRK14022 PRK14022
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;
2-481 0e+00

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;


Pssm-ID: 237588 [Multi-domain]  Cd Length: 481  Bit Score: 888.62  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369   2 ITIEQVLEVLKKDHNFRDIIDQDNYYYSWTEVTFDHLSYDSRDVTPSSLFFAKGAAFKPEFLENAVKAGLSFYVAEKDYQ 81
Cdd:PRK14022    1 ITIETLLDILKKDHNFREIIDQDHYHYNYSGVQFDDISYDSRTADEGTLFFAKGAYFKHKFLQNAITQGLKLYVSEKDYE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369  82 VGIPAIIVSDIKQAMSLVAQAFYQYPQDKLKLLAFTGTKGKTTAAYFAFNILKQSHKPAMLSTMNTTLDGKNFFKSTLTT 161
Cdd:PRK14022   81 VGIPQVIVPDIKKAMSLIAMEFYDNPQHKLKLLAFTGTKGKTTAAYFAYHILKQLHKPAMLSTMNTTLDGETFFKSALTT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 162 PESLDLFRMMAEAVANGMTHLIMEVSSQAYLTKRVYGLTFDVGVFLNISPDHIGPIEHPTFEDYFYHKRLLLENSRVVIV 241
Cdd:PRK14022  161 PESLDLFKMMAEAVDNGMTHLIMEVSSQAYLVGRVYGLTFDVGVFLNITPDHIGPIEHPTFEDYFYHKRLLMENSKAVVV 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 242 NSGMDHFDFIAEEVADKEHDFYGKNSDNAVKHGSGFSFKASGKLAGDYDIQLIGDFNQDNAMAAGLACLRLGASLQDIKE 321
Cdd:PRK14022  241 NSDMDHFSELLEQVTPQEHDFYGIDSENQIMASNAFSFEATGKLAGTYDIQLIGKFNQENAMAAGLACLRLGASLEDIQK 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 322 GIAQTSVPGRMEVLTQTNGAKIFVDYAHNGDSLDKLLQVVTSHQDGRISLILGAPGNKGESRRKDFGHVLNTYPDVDIIL 401
Cdd:PRK14022  321 GIAQTPVPGRMEVLTQSNGAKVFIDYAHNGDSLNKLIDVVEEHQKGKLILLLGAAGNKGESRRPDFGRVANRHPYLQVIL 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 402 TADDPNKEDPLAICQEIASHISREVRIIVDREKAIKTAMSETIDSKDAVVIAGKGADAFQIVNGKRDNYAGDIEVAKKYL 481
Cdd:PRK14022  401 TADDPNNEDPKMITQEIASHITHPVEIIDDRAEAIKHAMSITEGPGDAVIIAGKGADAYQIVPGHRDDYIGDEAAAKKYL 480
MurE COG0769
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 37-481 3.89e-146

UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440532 [Multi-domain]  Cd Length: 459  Bit Score: 425.65  E-value: 3.89e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369  37 HLSYDSRDVTPSSLFFA-KGAAFKP-EFLENAVKAGLSFYVAEKDYQV---GIPAIIVSDIKQAMSLVAQAFYQYPQDKL 111
Cdd:COG0769     1 GITYDSRKVKPGDLFVAlPGARVDGhDFIAQAIARGAVAVVTEAPGALlaaGVPVIVVPDPRAALALLAAAFYGHPSQKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 112 KLLAFTGTKGKTTAAYFAFNILKQS-HKPAMLSTMNTTLDGKnFFKSTLTTPESLDLFRMMAEAVANGMTHLIMEVSSQA 190
Cdd:COG0769    81 KLIGVTGTNGKTTTTYLLAQILRALgKKTGLIGTVGNGIGGE-LIPSSLTTPEALDLQRLLAEMVDAGVTHVVMEVSSHA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 191 YLTKRVYGLTFDVGVFLNISPDHIgpIEHPTFEDYFYHKRLL---LENSRVVIVNSGMDHFDFIAEEVA--------DKE 259
Cdd:COG0769   160 LDQGRVDGVRFDVAVFTNLTRDHL--DYHGTMEAYFAAKARLfdqLGPGGAAVINADDPYGRRLAAAAParvityglKAD 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 260 HDFYGKNSDnAVKHGSGFSFKASGKlAGDYDIQLIGDFNQDNAMAAGLACLRLGASLQDIKEGIAQ-TSVPGRMEVLTQT 338
Cdd:COG0769   238 ADLRATDIE-LSADGTRFTLVTPGG-EVEVRLPLIGRFNVYNALAAIAAALALGIDLEEILAALEKlKGVPGRMERVDGG 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 339 NGAKIFVDYAHNGDSLDKLLQVVTSHQDGRISLILGAPGNKGESRRKDFGHVLNTYPDVdIILTADDPNKEDPLAICQEI 418
Cdd:COG0769   316 QGPTVIVDYAHTPDALENVLEALRPHTKGRLIVVFGCGGDRDRGKRPLMGEIAARLADV-VIVTSDNPRSEDPAAIIADI 394

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1937413369 419 ASHISR--EVRIIVDREKAIKTAMSETiDSKDAVVIAGKGADAFQIVNGKRDNYAgDIEVAKKYL 481
Cdd:COG0769   395 LAGIPGagKVLVIPDRAEAIRYAIALA-KPGDVVLIAGKGHETYQIIGGVKIPFD-DREVAREAL 457
murE TIGR01085
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ...
 31-466 4.96e-83

UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273435 [Multi-domain]  Cd Length: 464  Bit Score: 264.18  E-value: 4.96e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369  31 TEVTfdHLSYDSRDVTPSSLFFA-KGAAFKP-EFLENAVKAGLSFYVAEKDYQV---GIPAIIVSDIKQAMSLVAQAFYQ 105
Cdd:TIGR01085   2 LEVT--GLTLDSREVKPGDLFVAiKGTHVDGhDFIHDAIANGAVAVVVERDVDFyvaPVPVIIVPDLRHALSSLAAAFYG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 106 YPQDKLKLLAFTGTKGKTTAAYFAFNILKQS-HKPAMLSTMNTTLDGKN--FFKSTLTTPESLDLFRMMAEAVANGMTHL 182
Cdd:TIGR01085  80 HPSKKLKVIGVTGTNGKTTTTSLIAQLLRLLgKKTGLIGTIGYRLGGNDliKNPAALTTPEALTLQSTLAEMVEAGAQYA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 183 IMEVSSQAYLTKRVYGLTFDVGVFLNISPDHIGpiEHPTFEDYFYHKRLL----LENSRVVIVN-----------SGMDH 247
Cdd:TIGR01085 160 VMEVSSHALAQGRVRGVRFDAAVFTNLSRDHLD--FHGTMENYFAAKASLftelGLKRFAVINLddeygaqfvkrLPKDI 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 248 FDFIAEEVADKEHDFYGKNSDNAVKHGSGFSFKASGKLaGDYDIQLIGDFNQDNAMAAGLACLRLG-ASLQDIKEGIAQ- 325
Cdd:TIGR01085 238 TVSAITQPADGRAQDIKITDSGYSFEGQQFTFETPAGE-GHLHTPLIGRFNVYNLLAALATLLHLGgIDLEDIVAALEKf 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 326 TSVPGRMEVLTQTNGAKIFVDYAHNGDSLDKLLQVVTSHQDGRISLILGAPGNKGESRRKDFGHVLNTYPDVdIILTADD 405
Cdd:TIGR01085 317 RGVPGRMELVDGGQKFLVIVDYAHTPDALEKALRTLRKHKDGRLIVVFGCGGDRDRGKRPLMGAIAEQLADL-VILTSDN 395

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1937413369 406 PNKEDPLAICQEIASHISREVR--IIVDREKAIKTAMSETIDsKDAVVIAGKGADAFQIVNGK 466
Cdd:TIGR01085 396 PRGEDPEQIIADILAGISEKEKvvIIADRRQAIRYAISNAKA-GDVVLIAGKGHEDYQIIGGE 457
Mur_ligase_M pfam08245
Mur ligase middle domain;
117-309 3.74e-35

Mur ligase middle domain;


Pssm-ID: 462409 [Multi-domain]  Cd Length: 199  Bit Score: 129.73  E-value: 3.74e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 117 TGTKGKTTAAYFAFNILKQSHKpaMLSTMnttldGKNFFKSTLTTPESLDLFRMMAEAVANGMTHLIMEVSSQAYLTKRV 196
Cdd:pfam08245   2 TGTNGKTTTTELIAAILSLAGG--VIGTI-----GTYIGKSGNTTNNAIGLPLTLAEMVEAGAEYAVLEVSSHGLGEGRL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 197 YGLT-FDVGVFLNISPDHIGpiEHPTFEDYFYHKRLLLENSR---VVIVNSGMDHFDFIAEEVADKEHD--FYGKNS--- 267
Cdd:pfam08245  75 SGLLkPDIAVFTNISPDHLD--FHGTMENYAKAKAELFEGLPedgIAVINADDPYGAFLIAKLKKAGVRviTYGIEGead 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1937413369 268 ---DNAVKHGSGFSFKASGKLAGDYDIQ--LIGDFNQDNAMAAGLAC 309
Cdd:pfam08245 153 lraANIELSSDGTSFDLFTVPGGELEIEipLLGRHNVYNALAAIAAA 199
 
Name Accession Description Interval E-value
PRK14022 PRK14022
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;
2-481 0e+00

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;


Pssm-ID: 237588 [Multi-domain]  Cd Length: 481  Bit Score: 888.62  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369   2 ITIEQVLEVLKKDHNFRDIIDQDNYYYSWTEVTFDHLSYDSRDVTPSSLFFAKGAAFKPEFLENAVKAGLSFYVAEKDYQ 81
Cdd:PRK14022    1 ITIETLLDILKKDHNFREIIDQDHYHYNYSGVQFDDISYDSRTADEGTLFFAKGAYFKHKFLQNAITQGLKLYVSEKDYE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369  82 VGIPAIIVSDIKQAMSLVAQAFYQYPQDKLKLLAFTGTKGKTTAAYFAFNILKQSHKPAMLSTMNTTLDGKNFFKSTLTT 161
Cdd:PRK14022   81 VGIPQVIVPDIKKAMSLIAMEFYDNPQHKLKLLAFTGTKGKTTAAYFAYHILKQLHKPAMLSTMNTTLDGETFFKSALTT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 162 PESLDLFRMMAEAVANGMTHLIMEVSSQAYLTKRVYGLTFDVGVFLNISPDHIGPIEHPTFEDYFYHKRLLLENSRVVIV 241
Cdd:PRK14022  161 PESLDLFKMMAEAVDNGMTHLIMEVSSQAYLVGRVYGLTFDVGVFLNITPDHIGPIEHPTFEDYFYHKRLLMENSKAVVV 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 242 NSGMDHFDFIAEEVADKEHDFYGKNSDNAVKHGSGFSFKASGKLAGDYDIQLIGDFNQDNAMAAGLACLRLGASLQDIKE 321
Cdd:PRK14022  241 NSDMDHFSELLEQVTPQEHDFYGIDSENQIMASNAFSFEATGKLAGTYDIQLIGKFNQENAMAAGLACLRLGASLEDIQK 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 322 GIAQTSVPGRMEVLTQTNGAKIFVDYAHNGDSLDKLLQVVTSHQDGRISLILGAPGNKGESRRKDFGHVLNTYPDVDIIL 401
Cdd:PRK14022  321 GIAQTPVPGRMEVLTQSNGAKVFIDYAHNGDSLNKLIDVVEEHQKGKLILLLGAAGNKGESRRPDFGRVANRHPYLQVIL 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 402 TADDPNKEDPLAICQEIASHISREVRIIVDREKAIKTAMSETIDSKDAVVIAGKGADAFQIVNGKRDNYAGDIEVAKKYL 481
Cdd:PRK14022  401 TADDPNNEDPKMITQEIASHITHPVEIIDDRAEAIKHAMSITEGPGDAVIIAGKGADAYQIVPGHRDDYIGDEAAAKKYL 480
murE PRK00139
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
 12-481 1.26e-158

UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional


Pssm-ID: 234660 [Multi-domain]  Cd Length: 460  Bit Score: 457.67  E-value: 1.26e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369  12 KKDHNFRDIIDqdnyyyswtEVTFDHLSYDSRDVTPSSLFFA-KGAAFK-PEFLENAVKAGLSFYVAEKDY--QVGIPAI 87
Cdd:PRK00139    1 MASMKLRDLLA---------PVEITGLTYDSRKVKPGDLFVAlPGHKVDgRDFIAQAIANGAAAVVAEADGeaGTGVPVI 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369  88 IVSDIKQAMSLVAQAFYQYPQDKLKLLAFTGTKGKTTAAYFAFNIL-KQSHKPAMLSTMNTTLDGKNFfKSTLTTPESLD 166
Cdd:PRK00139   72 IVPDLRKALALLAAAFYGHPSDKLKLIGVTGTNGKTTTAYLLAQILrLLGEKTALIGTLGNGIGGELI-PSGLTTPDALD 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 167 LFRMMAEAVANGMTHLIMEVSSQAYLTKRVYGLTFDVGVFLNISPDHIGpiEHPTFEDYFYHKRLLLEN-SRVVIVNSGM 245
Cdd:PRK00139  151 LQRLLAELVDAGVTYAAMEVSSHALDQGRVDGLKFDVAVFTNLSRDHLD--YHGTMEDYLAAKARLFSElGLAAVINADD 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 246 DHFDFIAEE-----VADKEHDFYGKNSDNavkHGSGFSFkasgKLAGDYDIQLIGDFNQDNAMAAGLACLRLGASLQDIK 320
Cdd:PRK00139  229 EVGRRLLALpdayaVSMAGADLRATDVEY---TDSGQTF----TLVTEVESPLIGRFNVSNLLAALAALLALGVPLEDAL 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 321 EGIAQ-TSVPGRMEVLTQTNGAKIFVDYAHNGDSLDKLLQVVTSHQDGRISLILGAPGNKGESRRKDFGHVLNTYPDVdI 399
Cdd:PRK00139  302 AALAKlQGVPGRMERVDAGQGPLVIVDYAHTPDALEKVLEALRPHAKGRLICVFGCGGDRDKGKRPLMGAIAERLADV-V 380

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 400 ILTADDPNKEDPLAICQEIASHIsreVRIIVDREKAIKTAMSETiDSKDAVVIAGKGADAFQIVNGKRDNYaGDIEVAKK 479
Cdd:PRK00139  381 IVTSDNPRSEDPAAIIADILAGI---YDVIEDRAEAIRYAIAQA-KPGDVVLIAGKGHEDYQIIGGVKIPF-DDREVARE 455


                  ..
gi 1937413369 480 YL 481
Cdd:PRK00139  456 AL 457
MurE COG0769
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 37-481 3.89e-146

UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440532 [Multi-domain]  Cd Length: 459  Bit Score: 425.65  E-value: 3.89e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369  37 HLSYDSRDVTPSSLFFA-KGAAFKP-EFLENAVKAGLSFYVAEKDYQV---GIPAIIVSDIKQAMSLVAQAFYQYPQDKL 111
Cdd:COG0769     1 GITYDSRKVKPGDLFVAlPGARVDGhDFIAQAIARGAVAVVTEAPGALlaaGVPVIVVPDPRAALALLAAAFYGHPSQKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 112 KLLAFTGTKGKTTAAYFAFNILKQS-HKPAMLSTMNTTLDGKnFFKSTLTTPESLDLFRMMAEAVANGMTHLIMEVSSQA 190
Cdd:COG0769    81 KLIGVTGTNGKTTTTYLLAQILRALgKKTGLIGTVGNGIGGE-LIPSSLTTPEALDLQRLLAEMVDAGVTHVVMEVSSHA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 191 YLTKRVYGLTFDVGVFLNISPDHIgpIEHPTFEDYFYHKRLL---LENSRVVIVNSGMDHFDFIAEEVA--------DKE 259
Cdd:COG0769   160 LDQGRVDGVRFDVAVFTNLTRDHL--DYHGTMEAYFAAKARLfdqLGPGGAAVINADDPYGRRLAAAAParvityglKAD 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 260 HDFYGKNSDnAVKHGSGFSFKASGKlAGDYDIQLIGDFNQDNAMAAGLACLRLGASLQDIKEGIAQ-TSVPGRMEVLTQT 338
Cdd:COG0769   238 ADLRATDIE-LSADGTRFTLVTPGG-EVEVRLPLIGRFNVYNALAAIAAALALGIDLEEILAALEKlKGVPGRMERVDGG 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 339 NGAKIFVDYAHNGDSLDKLLQVVTSHQDGRISLILGAPGNKGESRRKDFGHVLNTYPDVdIILTADDPNKEDPLAICQEI 418
Cdd:COG0769   316 QGPTVIVDYAHTPDALENVLEALRPHTKGRLIVVFGCGGDRDRGKRPLMGEIAARLADV-VIVTSDNPRSEDPAAIIADI 394

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1937413369 419 ASHISR--EVRIIVDREKAIKTAMSETiDSKDAVVIAGKGADAFQIVNGKRDNYAgDIEVAKKYL 481
Cdd:COG0769   395 LAGIPGagKVLVIPDRAEAIRYAIALA-KPGDVVLIAGKGHETYQIIGGVKIPFD-DREVAREAL 457
murE TIGR01085
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ...
 31-466 4.96e-83

UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273435 [Multi-domain]  Cd Length: 464  Bit Score: 264.18  E-value: 4.96e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369  31 TEVTfdHLSYDSRDVTPSSLFFA-KGAAFKP-EFLENAVKAGLSFYVAEKDYQV---GIPAIIVSDIKQAMSLVAQAFYQ 105
Cdd:TIGR01085   2 LEVT--GLTLDSREVKPGDLFVAiKGTHVDGhDFIHDAIANGAVAVVVERDVDFyvaPVPVIIVPDLRHALSSLAAAFYG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 106 YPQDKLKLLAFTGTKGKTTAAYFAFNILKQS-HKPAMLSTMNTTLDGKN--FFKSTLTTPESLDLFRMMAEAVANGMTHL 182
Cdd:TIGR01085  80 HPSKKLKVIGVTGTNGKTTTTSLIAQLLRLLgKKTGLIGTIGYRLGGNDliKNPAALTTPEALTLQSTLAEMVEAGAQYA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 183 IMEVSSQAYLTKRVYGLTFDVGVFLNISPDHIGpiEHPTFEDYFYHKRLL----LENSRVVIVN-----------SGMDH 247
Cdd:TIGR01085 160 VMEVSSHALAQGRVRGVRFDAAVFTNLSRDHLD--FHGTMENYFAAKASLftelGLKRFAVINLddeygaqfvkrLPKDI 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 248 FDFIAEEVADKEHDFYGKNSDNAVKHGSGFSFKASGKLaGDYDIQLIGDFNQDNAMAAGLACLRLG-ASLQDIKEGIAQ- 325
Cdd:TIGR01085 238 TVSAITQPADGRAQDIKITDSGYSFEGQQFTFETPAGE-GHLHTPLIGRFNVYNLLAALATLLHLGgIDLEDIVAALEKf 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 326 TSVPGRMEVLTQTNGAKIFVDYAHNGDSLDKLLQVVTSHQDGRISLILGAPGNKGESRRKDFGHVLNTYPDVdIILTADD 405
Cdd:TIGR01085 317 RGVPGRMELVDGGQKFLVIVDYAHTPDALEKALRTLRKHKDGRLIVVFGCGGDRDRGKRPLMGAIAEQLADL-VILTSDN 395

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1937413369 406 PNKEDPLAICQEIASHISREVR--IIVDREKAIKTAMSETIDsKDAVVIAGKGADAFQIVNGK 466
Cdd:TIGR01085 396 PRGEDPEQIIADILAGISEKEKvvIIADRRQAIRYAISNAKA-GDVVLIAGKGHEDYQIIGGE 457
PRK11929 PRK11929
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ...
 37-481 8.41e-71

bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;


Pssm-ID: 237025 [Multi-domain]  Cd Length: 958  Bit Score: 242.30  E-value: 8.41e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369  37 HLSYDSRDVTPSSLFFA-KGAAFKP-EFLENAVKAGLSFYVAEK---DYQVGIPA--IIVSDIKQAMSLVAQAFYQYPQD 109
Cdd:PRK11929   31 DLRLDSREVQPGDLFVAcRGAASDGrAFIDQALARGAAAVLVEAegeDQVAAADAlvLPVADLRKALGELAARWYGRPSE 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 110 KLKLLAFTGTKGKTTAAYFAFNILKQSHKPA-MLSTMNTTLDGKnFFKSTLTTPESLDLFRMMAEAVANGMTHLIMEVSS 188
Cdd:PRK11929  111 QLSLVAVTGTNGKTSCAQLLAQLLTRLGKPCgSIGTLGARLDGR-LIPGSLTTPDAIILHRILARMRAAGADAVAMEASS 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 189 QAYLTKRVYGLTFDVGVFLNISPDHIGpiEHPTFEDYFYHKRLLLEN----------------SRVVIVNSGMDHFDFIA 252
Cdd:PRK11929  190 HGLEQGRLDGLRIAVAGFTNLTRDHLD--YHGTMQDYEEAKAALFSKlpglgaavinaddpaaARLLAALPRGLKVGYSP 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 253 EEV-ADKE-HDFygknsdNAVKHGSGFSFKASGKLAgDYDIQLIGDFNQDNAMAAGLACLRLGASLQDIKEGIAQTS-VP 329
Cdd:PRK11929  268 QNAgADVQaRDL------RATAHGQVFTLATPDGSY-QLVTRLLGRFNVSNLLLVAAALKKLGLPLAQIARALAAVSpVP 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 330 GRMEVLTQT---NGAKIFVDYAHNGDSLDKLLQV---VTSHQDGRISLILGAPGNKGESRRKDFGHVLNTYPDVdIILTA 403
Cdd:PRK11929  341 GRMERVGPTagaQGPLVVVDYAHTPDALAKALTAlrpVAQARNGRLVCVFGCGGDRDKGKRPEMGRIAAELADR-VVVTS 419

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 404 DDPNKEDPLAICQEIASHISR--EVRIIVDREKAIKTAMSETiDSKDAVVIAGKGADAFQIVNGKRdNYAGDIEVAKKYL 481
Cdd:PRK11929  420 DNPRSEAPEAIIDQILAGIPAgaRVFVISDRAEAIRQAIWMA-APGDVILIAGKGHETYQEIGGRK-LFFDDREWARRAL 497
Mur_ligase_M pfam08245
Mur ligase middle domain;
117-309 3.74e-35

Mur ligase middle domain;


Pssm-ID: 462409 [Multi-domain]  Cd Length: 199  Bit Score: 129.73  E-value: 3.74e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 117 TGTKGKTTAAYFAFNILKQSHKpaMLSTMnttldGKNFFKSTLTTPESLDLFRMMAEAVANGMTHLIMEVSSQAYLTKRV 196
Cdd:pfam08245   2 TGTNGKTTTTELIAAILSLAGG--VIGTI-----GTYIGKSGNTTNNAIGLPLTLAEMVEAGAEYAVLEVSSHGLGEGRL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 197 YGLT-FDVGVFLNISPDHIGpiEHPTFEDYFYHKRLLLENSR---VVIVNSGMDHFDFIAEEVADKEHD--FYGKNS--- 267
Cdd:pfam08245  75 SGLLkPDIAVFTNISPDHLD--FHGTMENYAKAKAELFEGLPedgIAVINADDPYGAFLIAKLKKAGVRviTYGIEGead 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1937413369 268 ---DNAVKHGSGFSFKASGKLAGDYDIQ--LIGDFNQDNAMAAGLAC 309
Cdd:pfam08245 153 lraANIELSSDGTSFDLFTVPGGELEIEipLLGRHNVYNALAAIAAA 199
MurF COG0770
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 1-374 8.18e-27

UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440533 [Multi-domain]  Cd Length: 451  Bit Score: 112.50  E-value: 8.18e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369   1 MITIEQVLEVLKKDhnfrdiidqdnyYYSWTEVTFDHLSYDSRDVTPSSLFFA-KGAAFk-pEFLENAVKAGLSFYVAEK 78
Cdd:COG0770     2 LLTLAEIAEATGGR------------LIGDPDLVVTGVSTDSRKIKPGDLFVAlKGERFdghDFVAQALAKGAAAALVSR 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369  79 DYQVGIPAIIVSDIKQAMSLVAQAFYQypQDKLKLLAFTGTKGKTT-----AAyfafnILKQSHKpamlstmnttldgkn 153
Cdd:COG0770    70 PLPADLPLIVVDDTLKALQQLAAAHRA--RFNIPVIAITGSNGKTTtkemlAA-----VLSTKGK--------------- 127

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 154 ffksTLTTPES--------LDLFRMMAE---AVAN-GMTHL--ImevssqAYLTKrvygLTF-DVGVFLNISPDHIGpie 218
Cdd:COG0770   128 ----VLATPGNfnneigvpLTLLRLPEDhefAVLEmGMNHPgeI------AYLAR----IARpDIAVITNIGPAHLE--- 190

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 219 hpTFEDyfyhkrllLEN--------------SRVVIVNSGMDHFDFIAEEVA--------DKEHDFYGKnsdNAVKHGSG 276
Cdd:COG0770   191 --GFGS--------LEGiarakgeifeglppGGVAVLNADDPLLAALAERAKarvltfglSEDADVRAE---DIELDEDG 257

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 277 FSFKASGKLAG-DYDIQLIGDFNQDNAMAAGLACLRLGASLQDIKEGIAQ-TSVPGRMEVLTQTNGAKIFVD-Y-AhNGD 352
Cdd:COG0770   258 TRFTLHTPGGElEVTLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAfQPVKGRLEVIEGAGGVTLIDDsYnA-NPD 336

                         410       420
                  ....*....|....*....|...
gi 1937413369 353 SLDKLLQVVTS-HQDGRISLILG 374
Cdd:COG0770   337 SMKAALDVLAQlPGGGRRIAVLG 359
murF TIGR01143
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ...
 41-381 3.44e-26

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273468 [Multi-domain]  Cd Length: 417  Bit Score: 110.05  E-value: 3.44e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369  41 DSRDVTPSSLFFA-KGAAFKP-EFLENAVKAGLSFYVAEKDYQV--GIPAIIVSDIKQAmsLVAQAFYQYPQDKLKLLAF 116
Cdd:TIGR01143   2 DSRAIKPGDLFIAlKGERFDGhDFVEQALAAGAVAVVVDREVGPdnGLPQILVDDTLEA--LQALARAKRAKFSGKVIGI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 117 TGTKGKTTAAYFAFNILkqSHKPAMLSTmnttldGKNfFKSTLTTPesLDLFRMMAEAvangmTHLIME--VSSQ---AY 191
Cdd:TIGR01143  80 TGSSGKTTTKEMLAAIL--SHKYKVFAT------PGN-FNNEIGLP--LTLLRAPGDH-----DYAVLEmgASHPgeiAY 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 192 LTKRVyglTFDVGVFLNISPDHIGpiEHPTFEDYFYHKRLLLENSR---VVIVNSGMDHFDFIAEEVADKEHDFYGKNSD 268
Cdd:TIGR01143 144 LAEIA---KPDIAVITNIGPAHLE--GFGSLEGIAEAKGEILQGLKengIAVINADDPAFADLAKRLPNRNILSFGFEGG 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 269 NAV--------KHGSGFSFKASGKLAgDYDIQLIGDFNQDNAMAAGLACLRLGASLQDIKEGIAQTS-VPGRMEVLTqTN 339
Cdd:TIGR01143 219 DFVakdisysaLGSTSFTLVAPGGEF-EVSLPLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKlVKGRFEVQT-KN 296

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1937413369 340 GAKIFVD-YAHNGDSLDKLLQVVtSHQDGRISLILGAPGNKGE 381
Cdd:TIGR01143 297 GLTLIDDtYNANPDSMRAALDAL-ARFPGKKILVLGDMAELGE 338
MurD COG0771
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ...
 83-353 1.42e-18

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440534 [Multi-domain]  Cd Length: 445  Bit Score: 87.83  E-value: 1.42e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369  83 GIPaiIVSDIkqamSLvaqaFYQYPqdKLKLLAFTGTKGKTTAAYFAFNILKQSHKPAMLstmnttldGKNffkstLTTP 162
Cdd:COG0771    89 GIP--VIGEI----EL----AYRLS--PAPIIAITGTNGKTTTTTLIGHILKAAGLRVAV--------GGN-----IGTP 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 163 esldlfrmMAEAVANGMTH--LIMEVSS-QAYLTKRvygLTFDVGVFLNISPDHigpIE-HPTFEDYFYHKRLLLENSR- 237
Cdd:COG0771   144 --------LLDLLLEPEPPdvYVLELSSfQLETTPS---LRPDVAVILNITPDH---LDrHGSMEAYAAAKARIFANQTp 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 238 --VVIVNSGMDHFDFIAEEVADK----------EHDFYGKNSDNAVKHGSGFSFKASgklagdyDIQLIGDFNQDNAMAA 305
Cdd:COG0771   210 ddYAVLNADDPLTRALAEEAKARvvpfslkeplEGGAGLEDGKLVDRASGEELLPVD-------DLRLPGRHNLENALAA 282

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1937413369 306 GLACLRLGASLQDIKEGIAQ-TSVPGRMEVLTQTNGAKiFVDyahngDS 353
Cdd:COG0771   283 LAAARALGVPPEAIREALRSfKGLPHRLEFVAEINGVR-FIN-----DS 325
Mur_ligase_C pfam02875
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ...
 328-414 5.56e-18

Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.


Pssm-ID: 460731 [Multi-domain]  Cd Length: 87  Bit Score: 78.54  E-value: 5.56e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 328 VPGRMEVLTQTNGAKIFVDYAHNGDSLDKLLQVVTSHQDGRISLILGAPGNKGESRRKDFGHVLNTYPDvDIILTADDPN 407
Cdd:pfam02875   1 VPGRLEVVGENNGVLVIDDYAHNPDAMEAALRALRNLFPGRLILVFGGMGDRDAEFHALLGRLAAALAD-VVILTGDYPR 79


                  ....*..
gi 1937413369 408 KEDPLAI 414
Cdd:pfam02875  80 AEDPGAI 86
murD TIGR01087
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ...
 7-346 2.20e-17

UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273436 [Multi-domain]  Cd Length: 433  Bit Score: 84.31  E-value: 2.20e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369   7 VLEVLKKDHNFRDIIDQDnyyyswTEVTFDHLSYDSRDVTPSSLFFAKgaafKPEFLENA---VKA-GLSFY--VAEKDY 80
Cdd:TIGR01087  14 VARFLHKKGAEVTVTDLK------PNEELEPSMGQLRLNEGSVLHTGL----HLEDLNNAdlvVKSpGIPPDhpLVQAAA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369  81 QVGIPaiIVSDIkqamslvaQAFYQYPqdKLKLLAFTGTKGKTTAAYFAFNILKQSHKPAMLstmnttldGKNFfkstlT 160
Cdd:TIGR01087  84 KRGIP--VVGDI--------ELFLRLV--PLPVVAITGTNGKTTTTSLLYHLLKAAGLKAFL--------GGNI-----G 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 161 TPeSLDLFRmmaeavANGMTHLIMEVSSqaYLTKRVYGLTFDVGVFLNISPDHIGpiEHPTFEDYFYHKRLLLENSR--- 237
Cdd:TIGR01087 139 TP-ALEVLD------QEGAELYVLELSS--FQLETTESLRPEIALILNISEDHLD--WHGSFEDYVAAKLKIFARQTegd 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 238 VVIVNSGMDHFDFiAEEVADKEHDFYGKNSDNAVK---HGSGFSFKasgklAGDYDIQLIGDFNQDNAMAAGLACLRLGA 314
Cdd:TIGR01087 208 VAVLNADDPRFAR-LAQKSKAQVIWFSVEKDAERGlciRDGGLYLK-----PNDLEGSLLGLHNAENILAAIALAKSLGL 281

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1937413369 315 SLQDIKEGIAQ-TSVPGRMEVLTQTNGAKiFVD 346
Cdd:TIGR01087 282 NLEAILEALRSfKGLPHRLEYVGQKNGVH-FYN 313
PRK11929 PRK11929
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ...
 38-381 2.62e-17

bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;


Pssm-ID: 237025 [Multi-domain]  Cd Length: 958  Bit Score: 85.14  E-value: 2.62e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369  38 LSYDSRDVTPSSLFFA-KGAAFKPE-FLENAVKAGLSFYVAEKDY-QVGIPAIIVSDIKQAMSLVAQAFYQypQDKLKLL 114
Cdd:PRK11929  529 VSTDSRSVGRGELFVAlRGENFDGHdYLPQAFAAGACAAVVERQVaDVDLPQIVVDDTRAALGRLATAWRA--RFSLPVV 606

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 115 AFTGTKGKTTaayfafniLKQshkpaMLSTMNTTLDGKNffkSTLTTPES--------LDLFRMM----AEAVANGMTHl 182
Cdd:PRK11929  607 AITGSNGKTT--------TKE-----MIAAILAAWQGED---RVLATEGNfnneigvpLTLLRLRaqhrAAVFELGMNH- 669

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 183 imeVSSQAYLTKRVYGltfDVGVFLNISPDHIG------PIEHPTFEDYFYhkrlLLENSrVVIVNSGMDHFDFIAEEVA 256
Cdd:PRK11929  670 ---PGEIAYLAAIAAP---TVALVTNAQREHQEfmhsveAVARAKGEIIAA----LPEDG-VAVVNGDDPYTAIWAKLAG 738

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 257 DKEHDFYGKNSDNAVKH---GSGFSFKASGKL-------AG--DYDIQLIGDFNQDNAMAAGLACLRLGASLQDIKEGIA 324
Cdd:PRK11929  739 ARRVLRFGLQPGADVYAekiAKDISVGEAGGTrcqvvtpAGsaEVYLPLIGEHNLRNALAAIACALAAGASLKQIRAGLE 818

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1937413369 325 Q-TSVPGRMEVLTQTNGAKIFVD-YAHNGDSLDKLLQVVTSHQDGRISLILGAPGNKGE 381
Cdd:PRK11929  819 RfQPVAGRMQRRRLSCGTRIIDDtYNANPDSMRAAIDVLAELPNGPRALVLGDMLELGD 877
MurC COG0773
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ...
 202-481 9.62e-14

UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440536 [Multi-domain]  Cd Length: 451  Bit Score: 73.18  E-value: 9.62e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 202 DVGVFLNISPDHIgpiEH-PTFEDYF--YHK--RLLLENSRVvIVNSGmdhfDFIAEEVADKEHD---FYGKNSD----- 268
Cdd:COG0773   173 DIAVVTNIEADHL---DIyGDLEAIKeaFHEfaRNVPFYGLL-VLCAD----DPGLRELLPRCGRpviTYGFSEDadyra 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 269 -NAVKHGSGFSFKAS--GKLAGDYDIQLIGDFNQDNAMAAGLACLRLGASLQDIKEGIAQ-TSVPGRMEVLTQTNGAKIF 344
Cdd:COG0773   245 eNIRIDGGGSTFDVLrrGEELGEVELNLPGRHNVLNALAAIAVALELGVDPEAIAEALASfKGVKRRFELKGEVGGVTVI 324

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 345 VDYAHNGDSLDKLLQVV-TSHQDGRISLILgapgnkgE----SRRKD----FGHVLNtypDVD-IILTADDPNKEDPL-- 412
Cdd:COG0773   325 DDYAHHPTEIAATLAAArEKYPDRRLVAVF-------QphrySRTRDfldeFAEALS---LADeVILLDIYAAREKPIpg 394

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1937413369 413 ----AICQEIASHiSREVRIIVDREKAIKtAMSETIDSKDAVVIAGkgadafqivngkrdnyAGDI-EVAKKYL 481
Cdd:COG0773   395 vsseDLAEAIRKR-GKDVVYVPDLDELVE-ALAEIARPGDVVLTMG----------------AGDIgGLGEKLL 450
murF PRK10773
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed
 33-332 2.58e-11

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed


Pssm-ID: 182718 [Multi-domain]  Cd Length: 453  Bit Score: 65.44  E-value: 2.58e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369  33 VTFDHLSYDSRDVTPSSLFFA-KGAAFKP-EFLENAVKAGLSFYVAEKDYQVGIPAIIVSDIKQAMSLVAQAFYQypQDK 110
Cdd:PRK10773   22 ITIDAVTTDTRKVTPGCLFVAlKGERFDAhDFADDAKAAGAGALLVSRPLDIDLPQLVVKDTRLAFGQLAAWVRQ--QVP 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 111 LKLLAFTGTKGKTTAAYFAFNILKQSHKpamlsTMNTTLDGKNFFKSTLTtpesldLFRMMAE---AVAN-GMTHlIMEV 186
Cdd:PRK10773  100 ARVVALTGSSGKTSVKEMTAAILRQCGN-----TLYTAGNLNNDIGVPLT------LLRLTPEhdyAVIElGANH-QGEI 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 187 SSQAYLTKRVYGLTFdvgvflNISPDHI-------------GPIehptfedyFYHkrlLLENSrVVIVNSGMDHFDFIAE 253
Cdd:PRK10773  168 AYTVSLTRPEAALVN------NLAAAHLegfgslagvakakGEI--------FSG---LPENG-IAIMNADSNDWLNWQS 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 254 EVADK-----------EHDFYGknSDNAVK-HGSGFSFKASgklAGDYDIQL--IGDFNQDNAMAAGLACLRLGASLQDI 319
Cdd:PRK10773  230 VIGSKtvwrfspnaanSVDFTA--TNIHVTsHGTEFTLHTP---TGSVDVLLplPGRHNIANALAAAALAMSVGATLDAV 304

                         330
                  ....*....|....
gi 1937413369 320 KEGIAQ-TSVPGRM 332
Cdd:PRK10773  305 KAGLANlKAVPGRL 318
PRK14016 PRK14016
cyanophycin synthetase; Provisional
 113-334 2.66e-11

cyanophycin synthetase; Provisional


Pssm-ID: 237586 [Multi-domain]  Cd Length: 727  Bit Score: 65.95  E-value: 2.66e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 113 LLAFTGTKGKTTAAYFAFNILKQS-HKPAMLSTMNTTLDGKNFFKSTLTTPES--LDLFRMMAEAVangmthlIMEVSSQ 189
Cdd:PRK14016  482 IVAVTGTNGKTTTTRLIAHILKLSgKRVGMTTTDGVYIDGRLIDKGDCTGPKSarRVLMNPDVEAA-------VLETARG 554

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 190 AYLTKrvyGLTFD---VGVFLNISPDHIG--PIEhpTFEDYFYHKRLLLENSR---VVIVNSGmdhfDFIAEEVADK--- 258
Cdd:PRK14016  555 GILRE---GLAYDrcdVGVVTNIGEDHLGlgGIN--TLEDLAKVKRVVVEAVKpdgYAVLNAD----DPMVAAMAERckg 625

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 259 EHDFYGKNSDNAV--KHgsgfsfKASGKLA------------GDYDIQLIG------------DFNQDNAMAAGLACLRL 312
Cdd:PRK14016  626 KVIFFSMDPDNPViaEH------RAQGGRAvyvegdyivlaeGGWEIRIISladipltlggkaGFNIENALAAIAAAWAL 699

                         250       260
                  ....*....|....*....|....*..
gi 1937413369 313 GASLQDIKEGIA-----QTSVPGRMEV 334
Cdd:PRK14016  700 GIDIELIRAGLRtfvsdAAQAPGRFNL 726
murD PRK14106
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
 110-382 8.87e-08

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional


Pssm-ID: 184511 [Multi-domain]  Cd Length: 450  Bit Score: 54.21  E-value: 8.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 110 KLKLLAFTGTKGKTTAAYFAFNILKQSHKPamlstmntTLDGKNFFKSTLTTPESLDlfrmmaeavanGMTHLIMEVSS- 188
Cdd:PRK14106  107 KAPIVAITGTNGKTTTTTLLGEIFKNAGRK--------TLVAGNIGYPLIDAVEEYG-----------EDDIIVAEVSSf 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 189 QAYLTKRvygLTFDVGVFLNISPDHIGpiEHPTFEDYFYHKRLLLENSR---VVIVNsgMDhfDFIAEEVAD-------- 257
Cdd:PRK14106  168 QLETIKE---FKPKVGCILNITPDHLD--RHKTMENYIKAKARIFENQRpsdYTVLN--YD--DPRTRSLAKkakarvif 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 258 --KEHDFYgknsdNAVKHGSGFSFKASGKLAGDY----DIQLIGDFNQDNAMAAGLACLRLGASLQDIKEGIAQ-TSVPG 330
Cdd:PRK14106  239 fsRKSLLE-----EGVFVKNGKIVISLGGKEEEVididEIFIPGEHNLENALAATAAAYLLGISPDVIANTLKTfKGVEH 313

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1937413369 331 RMEVLTQTNGAKIFVDY-AHNGDSLDKLLQVVtshqDGRISLILGAPgNKGES 382
Cdd:PRK14106  314 RIEFVAEINGVKFINDSkGTNPDAAIKALEAY----ETPIVLIAGGY-DKGSD 361
PLN02913 PLN02913
dihydrofolate synthetase
 288-379 1.10e-05

dihydrofolate synthetase


Pssm-ID: 178501 [Multi-domain]  Cd Length: 510  Bit Score: 47.89  E-value: 1.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369 288 DYDIQLIGDFNQDNAMAAGLA--CLRL-GASLQD--IKEGIAQTSVPGRMEVLTQT-------NGAKIFVDYAHNGDSLD 355
Cdd:PLN02913  304 DVNLRMLGSHQLQNAVTAACAalCLRDqGWRISDasIRAGLENTNLLGRSQFLTSKeaevlglPGATVLLDGAHTKESAK 383

                          90       100
                  ....*....|....*....|....*
gi 1937413369 356 KLLQVV-TSHQDGRISLILGAPGNK 379
Cdd:PLN02913  384 ALVDTIkTAFPEARLALVVAMASDK 408
PRK14093 PRK14093
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; ...
 38-124 4.94e-04

UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional


Pssm-ID: 184501 [Multi-domain]  Cd Length: 479  Bit Score: 42.45  E-value: 4.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937413369  38 LSYDSRDVTPSSLFFA-KGAAFKP-EFLENAVKAGLSFYVAEKDYQVGIPA----IIVSDIKQAMSLVAQAfyQYPQDKL 111
Cdd:PRK14093   31 ISIDSRTLAPGDAYFAiKGDVHDGhAFVAAALKAGAALAVVERAQRDKFAAdaplLVVDDVLAALRDLGRA--ARARLEA 108

                          90
                  ....*....|...
gi 1937413369 112 KLLAFTGTKGKTT 124
Cdd:PRK14093  109 KVIAVTGSVGKTS 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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