|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09243 |
PRK09243 |
nicotinate phosphoribosyltransferase; Validated |
1-464 |
0e+00 |
|
nicotinate phosphoribosyltransferase; Validated
Pssm-ID: 236426 [Multi-domain] Cd Length: 464 Bit Score: 817.09 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 1 MYKDDSLTLHTDLYQINMMQVYFNQGIHNKKAVFEVYFRQLPFKNGFAVFAGLERIVNYLESLTFSETDIAYLKDLG-YP 79
Cdd:PRK09243 3 MYNDDSLALLTDLYELTMAQAYLRDGIHNRRAVFELFFRKLPFGRGYAVFAGLERLLEYLENLRFTEEDIEYLRSLGiFD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 80 EDFLDYLANLKLELTINSALEGDLVFANEPIFQVEGPLAQCQLVETALLNILNYQILIATKAARIRSVIEDAPLLEFGTR 159
Cdd:PRK09243 83 EDFLDYLRNFRFTGDVRAVPEGELVFPNEPLLRVEGPLAEAQLLETLLLNIINFQTLIATKAARIVSAAGGRPLLEFGSR 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 160 RAQEMDAAIWGTRAAVIGGADATSNVRAGKIFGIPVSGTHAHALVQAYGNDYDAFKAYAST-HKDCVFLVDTYDTLKIGV 238
Cdd:PRK09243 163 RAQGPDAAVWAARAAYIGGFDATSNVLAGKRYGIPVSGTMAHSFVQAFDDEYEAFRAYAETyPDNTVLLVDTYDTLKSGV 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 239 PNAIRVAKELGDKINFLGVRLDSGDLAYLSKQVRKQLDAAGFPDAKIYASNDLDENTILNLKMQKAKIDVWGVGTKLITA 318
Cdd:PRK09243 243 PNAIKVAKELGDGIELGGVRIDSGDLAYLSKKVRKMLDEAGFTDTKIVASNDLDEYTIASLKLQGAPIDGFGVGTKLVTG 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 319 YDQPALGAVYKIVSIEDNQGvMHDTIKLSNNAEKVSTPGKKQVWRITsRAKGKSEGDYITFADTDVNalDEINMFHPTYT 398
Cdd:PRK09243 323 SDAPALGGVYKLVAIEGEGG-MIPKIKLSNSPEKVTTPGRKQVYRIY-DKGGKAEADVITLADEEEE--EPLKMFHPVHT 398
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1937373633 399 YINKTVRDFDAVPLLVPIYDKGQLIYDLPSLDEIKAYATKELDELWNEYKRVLNPQDYPVDLAKDV 464
Cdd:PRK09243 399 YKSKTVKNFDAEPLLVPVMENGKRVYELPSLEEIRAYAAAQLASLPEEYKRLLNPHAYPVDLSQAL 464
|
|
| NAPRTase_put |
TIGR01513 |
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of ... |
8-464 |
0e+00 |
|
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of proteins, one of which includes experimentally characterized examples of nicotinate phosphoribosyltransferase, an the first enzyme of NAD salvage biosynthesis. This model represents the other family. Members have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. One argument suggesting that this family represents the same enzyme is that no species has a member of both families. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria. NAD and NADP are ubiquitous in life. Most members of this family are Gram-positive bacteria. An additional set of mutually closely related archaeal sequences score between the trusted and noise cutoffs. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Pssm-ID: 273666 [Multi-domain] Cd Length: 443 Bit Score: 656.74 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 8 TLHTDLYQINMMQVYFNQGIHNKKAVFEVYFRQLPFKNGFAVFAGLERIVNYLESLTFSETDIAYLKDLG-YPEDFLDYL 86
Cdd:TIGR01513 1 ALLTDLYELTMAQGYFREGKANQPAVFEVFFRKLPFGRGYAVFAGLEDLLEFLENFRFDAEDIEYLASLGiFDDAFLDYL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 87 ANLKLELTINSALEGDLVFANEPIFQVEGPLAQCQLVETALLNILNYQILIATKAARIRSVIEDAPLLEFGTRRAQEMDA 166
Cdd:TIGR01513 81 REFRFSGTVRALPEGSLVFPNEPLLQVEGPLIEAQLLETLVLNIINFQTLIATKAARIVLAAGGKPLLEFGLRRAQGPDA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 167 AIWGTRAAVIGGADATSNVRAGKIFGIPVSGTHAHALVQAYGNDYDAFKAYASTH-KDCVFLVDTYDTLKIGVPNAIRVA 245
Cdd:TIGR01513 161 ALKAARAAYIGGADGTSNVLAGRLYGIPVSGTMAHSFVMSFDNELAAFRAYAKLYpKATVLLVDTYDTLRSGLPNAIAVA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 246 KELGDKINFLGVRLDSGDLAYLSKQVRKQLDAAGFPDAKIYASNDLDENTILNLKMQKAKIDVWGVGTKLITAYDQPALG 325
Cdd:TIGR01513 241 KELGEQGKVVGVRIDSGDLLYLSKQARKQLDAAGLTQVKIVVSNDLDENSIAALKAEGAPIDVYGVGTSLVTASDAPALG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 326 AVYKIVSIEDnQGVMhdtiKLSNNAEKVSTPGKKQVWRITsRAKGKSEGDYITFADTDvnaldeinmfHPTYTYINKTVR 405
Cdd:TIGR01513 321 GVYKLVAYEG-RPVM----KLSENPEKSTLPGRKQVFRLY-DATGKFLGDELTLADEP----------IEDLNQEKCTPV 384
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 1937373633 406 DFDAVPLLVPIYDKGQLIYDLPSLDEIKAYATKELDELWNEYKRVLNPQDYPVDLAKDV 464
Cdd:TIGR01513 385 FAPVEPLLRLVMKNGQRVRPLPSLAEIRARAREQLSKLPPEYLRLLNPHVYPVSLSPRL 443
|
|
| PncB |
COG1488 |
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ... |
4-471 |
0e+00 |
|
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis
Pssm-ID: 441097 [Multi-domain] Cd Length: 445 Bit Score: 651.44 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 4 DDSLTLHTDLYQINMMQVYFNQGIHNKKAVFEVYFRQLPFKNGFAVFAGLERIVNYLESLTFSETDIAYLKDLG-YPEDF 82
Cdd:COG1488 1 MDNLALLTDLYKLTMAQAYLPEGTANRRAVFELFFRRLPFGRGYVVFAGLQRFLKYLENLRFTEEDIAYLRSLGvFDEDF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 83 LDYLANLKLELTINSALEGDLVFANEPIFQVEGPLAQCQLVETALLNILNYQILIATKAARIRSVIEDAPLLEFGTRRAQ 162
Cdd:COG1488 81 LDYLADFRFPGDIRAVPEGTVVFPGEPLLTVEGTLPEAQLLETLLLNILNYPTLIATKAARIVQAAGGRPLHDFGLRRAH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 163 EMDAAIWGTRAAVIGGADATSNVRAGKIFGIPVSGTHAHALVQAYGNDYDAFKAYASTHKD-CVFLVDTYDTLKiGVPNA 241
Cdd:COG1488 161 GLEAAVAAARAAYLAGFAGTSNVLAGRYYGIPSVGTMAHSFVQAHDDELEAFRAFAEAYPDgTTLLVDTYDTLS-GVPNA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 242 IRVAKELGDKINFLGVRLDSGDLAYLSKQVRKQLDAAGFPDAKIYASNDLDENTILNLKMQKAKIDVWGVGTKLITAYDQ 321
Cdd:COG1488 240 IELAKELLARGGLLGIRLDSGDLAYLSKQARELLDEAGLPDVRIIASDDLDEYRIAALLEQGAPIDVFGVGTRLVTSSDR 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 322 PALGAVYKIVSIEDNqGVMHDTIKLSNNAEKVSTPGKKQVWRItsRAKGKSEGDYITFADTDVNALDEinmfhptytyin 401
Cdd:COG1488 320 PTLGFVYKLVAVEGD-GEWRPVIKLSETPGKKSKPGRKQVYRR--DEDGKATADLVALEDEPLPGEPE------------ 384
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 402 ktvrdfdavPLLVPIYDKGQLIYDLPSLDEIKAYATKELDELWNEYKRVLNPQDYPVDLAKDVWDNKMTL 471
Cdd:COG1488 385 ---------PLLVPVFRDGKLVYELPSLEEIRERAAAQLAELPEELKRLRNPPAYPVDLSEALWDLKEQL 445
|
|
| NAPRTase_A |
cd01570 |
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate ... |
9-331 |
0e+00 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria and eukaryota (except funghi).
Pssm-ID: 238804 [Multi-domain] Cd Length: 327 Bit Score: 540.24 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 9 LHTDLYQINMMQVYFNQGIHNKKAVFEVYFRQLPFKNGFAVFAGLERIVNYLESLTFSETDIAYLKDLG-YPEDFLDYLA 87
Cdd:cd01570 2 LLTDLYQLTMAQAYWKEGKHNKPAVFELFFRKLPFGGGYAVFAGLEELLEYLENFRFTEEDIDYLRSLGiFDEEFLDYLR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 88 NLKLELTINSALEGDLVFANEPIFQVEGPLAQCQLVETALLNILNYQILIATKAARIRSVIEDAPLLEFGTRRAQEMDAA 167
Cdd:cd01570 82 GFRFTGTIYAIPEGEVVFPNEPLLTVEGPLIEAQLLETLLLNLINFQTLIATKAARVRLAAGGRPLLEFGLRRAQGPDAA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 168 IWGTRAAVIGGADATSNVRAGKIFGIPVSGTHAHALVQAYGNDYDAFKAYASTHKD-CVFLVDTYDTLKIGVPNAIRVAK 246
Cdd:cd01570 162 LSAARAAYIGGFDGTSNVLAGKLYGIPVSGTMAHSFVQAFDDELAAFRAFAEAYPDnFTLLVDTYDTLRSGLPNAIAVAK 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 247 ELGDK-INFLGVRLDSGDLAYLSKQVRKQLDAAGFPDAKIYASNDLDENTILNLKMQKAKIDVWGVGTKLITAYDQPALG 325
Cdd:cd01570 242 ELGALgYRLVGVRIDSGDLAYLSKEARKMLDEAGLTKVKIVASNDLDEYTIAALNAQGAPIDAFGVGTRLVTSQSQPALG 321
|
....*.
gi 1937373633 326 AVYKIV 331
Cdd:cd01570 322 GVYKLV 327
|
|
| NAPRTase_N |
pfam17767 |
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate ... |
9-132 |
1.64e-44 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This is the N-terminal domain of the enzyme.
Pssm-ID: 465494 [Multi-domain] Cd Length: 125 Bit Score: 152.28 E-value: 1.64e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 9 LHTDLYQINMMQVYFNQGIhNKKAVFEVYFRQLPFKNGFAVFAGLERIVNYLESLTFSETDIAYLKD-LGY-PEDFLDYL 86
Cdd:pfam17767 1 LDTDLYKLTMAQAYFKNGP-DVQVVFEFFNRTNPFGGLYAVFAGLEEQIEFLENLRFTEEEIEYLRRsLPYfKPDFLDYL 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1937373633 87 ANLKLELTINSALEGDLVFANEPIFQVEGPLAQCQLVETALLNILN 132
Cdd:pfam17767 80 RNFRFDPSIVAVPEGEVVFPGEPLLRIEGPWLETILLETPLLAIVN 125
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09243 |
PRK09243 |
nicotinate phosphoribosyltransferase; Validated |
1-464 |
0e+00 |
|
nicotinate phosphoribosyltransferase; Validated
Pssm-ID: 236426 [Multi-domain] Cd Length: 464 Bit Score: 817.09 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 1 MYKDDSLTLHTDLYQINMMQVYFNQGIHNKKAVFEVYFRQLPFKNGFAVFAGLERIVNYLESLTFSETDIAYLKDLG-YP 79
Cdd:PRK09243 3 MYNDDSLALLTDLYELTMAQAYLRDGIHNRRAVFELFFRKLPFGRGYAVFAGLERLLEYLENLRFTEEDIEYLRSLGiFD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 80 EDFLDYLANLKLELTINSALEGDLVFANEPIFQVEGPLAQCQLVETALLNILNYQILIATKAARIRSVIEDAPLLEFGTR 159
Cdd:PRK09243 83 EDFLDYLRNFRFTGDVRAVPEGELVFPNEPLLRVEGPLAEAQLLETLLLNIINFQTLIATKAARIVSAAGGRPLLEFGSR 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 160 RAQEMDAAIWGTRAAVIGGADATSNVRAGKIFGIPVSGTHAHALVQAYGNDYDAFKAYAST-HKDCVFLVDTYDTLKIGV 238
Cdd:PRK09243 163 RAQGPDAAVWAARAAYIGGFDATSNVLAGKRYGIPVSGTMAHSFVQAFDDEYEAFRAYAETyPDNTVLLVDTYDTLKSGV 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 239 PNAIRVAKELGDKINFLGVRLDSGDLAYLSKQVRKQLDAAGFPDAKIYASNDLDENTILNLKMQKAKIDVWGVGTKLITA 318
Cdd:PRK09243 243 PNAIKVAKELGDGIELGGVRIDSGDLAYLSKKVRKMLDEAGFTDTKIVASNDLDEYTIASLKLQGAPIDGFGVGTKLVTG 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 319 YDQPALGAVYKIVSIEDNQGvMHDTIKLSNNAEKVSTPGKKQVWRITsRAKGKSEGDYITFADTDVNalDEINMFHPTYT 398
Cdd:PRK09243 323 SDAPALGGVYKLVAIEGEGG-MIPKIKLSNSPEKVTTPGRKQVYRIY-DKGGKAEADVITLADEEEE--EPLKMFHPVHT 398
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1937373633 399 YINKTVRDFDAVPLLVPIYDKGQLIYDLPSLDEIKAYATKELDELWNEYKRVLNPQDYPVDLAKDV 464
Cdd:PRK09243 399 YKSKTVKNFDAEPLLVPVMENGKRVYELPSLEEIRAYAAAQLASLPEEYKRLLNPHAYPVDLSQAL 464
|
|
| NAPRTase_put |
TIGR01513 |
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of ... |
8-464 |
0e+00 |
|
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of proteins, one of which includes experimentally characterized examples of nicotinate phosphoribosyltransferase, an the first enzyme of NAD salvage biosynthesis. This model represents the other family. Members have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. One argument suggesting that this family represents the same enzyme is that no species has a member of both families. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria. NAD and NADP are ubiquitous in life. Most members of this family are Gram-positive bacteria. An additional set of mutually closely related archaeal sequences score between the trusted and noise cutoffs. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Pssm-ID: 273666 [Multi-domain] Cd Length: 443 Bit Score: 656.74 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 8 TLHTDLYQINMMQVYFNQGIHNKKAVFEVYFRQLPFKNGFAVFAGLERIVNYLESLTFSETDIAYLKDLG-YPEDFLDYL 86
Cdd:TIGR01513 1 ALLTDLYELTMAQGYFREGKANQPAVFEVFFRKLPFGRGYAVFAGLEDLLEFLENFRFDAEDIEYLASLGiFDDAFLDYL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 87 ANLKLELTINSALEGDLVFANEPIFQVEGPLAQCQLVETALLNILNYQILIATKAARIRSVIEDAPLLEFGTRRAQEMDA 166
Cdd:TIGR01513 81 REFRFSGTVRALPEGSLVFPNEPLLQVEGPLIEAQLLETLVLNIINFQTLIATKAARIVLAAGGKPLLEFGLRRAQGPDA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 167 AIWGTRAAVIGGADATSNVRAGKIFGIPVSGTHAHALVQAYGNDYDAFKAYASTH-KDCVFLVDTYDTLKIGVPNAIRVA 245
Cdd:TIGR01513 161 ALKAARAAYIGGADGTSNVLAGRLYGIPVSGTMAHSFVMSFDNELAAFRAYAKLYpKATVLLVDTYDTLRSGLPNAIAVA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 246 KELGDKINFLGVRLDSGDLAYLSKQVRKQLDAAGFPDAKIYASNDLDENTILNLKMQKAKIDVWGVGTKLITAYDQPALG 325
Cdd:TIGR01513 241 KELGEQGKVVGVRIDSGDLLYLSKQARKQLDAAGLTQVKIVVSNDLDENSIAALKAEGAPIDVYGVGTSLVTASDAPALG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 326 AVYKIVSIEDnQGVMhdtiKLSNNAEKVSTPGKKQVWRITsRAKGKSEGDYITFADTDvnaldeinmfHPTYTYINKTVR 405
Cdd:TIGR01513 321 GVYKLVAYEG-RPVM----KLSENPEKSTLPGRKQVFRLY-DATGKFLGDELTLADEP----------IEDLNQEKCTPV 384
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 1937373633 406 DFDAVPLLVPIYDKGQLIYDLPSLDEIKAYATKELDELWNEYKRVLNPQDYPVDLAKDV 464
Cdd:TIGR01513 385 FAPVEPLLRLVMKNGQRVRPLPSLAEIRARAREQLSKLPPEYLRLLNPHVYPVSLSPRL 443
|
|
| PncB |
COG1488 |
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ... |
4-471 |
0e+00 |
|
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis
Pssm-ID: 441097 [Multi-domain] Cd Length: 445 Bit Score: 651.44 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 4 DDSLTLHTDLYQINMMQVYFNQGIHNKKAVFEVYFRQLPFKNGFAVFAGLERIVNYLESLTFSETDIAYLKDLG-YPEDF 82
Cdd:COG1488 1 MDNLALLTDLYKLTMAQAYLPEGTANRRAVFELFFRRLPFGRGYVVFAGLQRFLKYLENLRFTEEDIAYLRSLGvFDEDF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 83 LDYLANLKLELTINSALEGDLVFANEPIFQVEGPLAQCQLVETALLNILNYQILIATKAARIRSVIEDAPLLEFGTRRAQ 162
Cdd:COG1488 81 LDYLADFRFPGDIRAVPEGTVVFPGEPLLTVEGTLPEAQLLETLLLNILNYPTLIATKAARIVQAAGGRPLHDFGLRRAH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 163 EMDAAIWGTRAAVIGGADATSNVRAGKIFGIPVSGTHAHALVQAYGNDYDAFKAYASTHKD-CVFLVDTYDTLKiGVPNA 241
Cdd:COG1488 161 GLEAAVAAARAAYLAGFAGTSNVLAGRYYGIPSVGTMAHSFVQAHDDELEAFRAFAEAYPDgTTLLVDTYDTLS-GVPNA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 242 IRVAKELGDKINFLGVRLDSGDLAYLSKQVRKQLDAAGFPDAKIYASNDLDENTILNLKMQKAKIDVWGVGTKLITAYDQ 321
Cdd:COG1488 240 IELAKELLARGGLLGIRLDSGDLAYLSKQARELLDEAGLPDVRIIASDDLDEYRIAALLEQGAPIDVFGVGTRLVTSSDR 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 322 PALGAVYKIVSIEDNqGVMHDTIKLSNNAEKVSTPGKKQVWRItsRAKGKSEGDYITFADTDVNALDEinmfhptytyin 401
Cdd:COG1488 320 PTLGFVYKLVAVEGD-GEWRPVIKLSETPGKKSKPGRKQVYRR--DEDGKATADLVALEDEPLPGEPE------------ 384
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 402 ktvrdfdavPLLVPIYDKGQLIYDLPSLDEIKAYATKELDELWNEYKRVLNPQDYPVDLAKDVWDNKMTL 471
Cdd:COG1488 385 ---------PLLVPVFRDGKLVYELPSLEEIRERAAAQLAELPEELKRLRNPPAYPVDLSEALWDLKEQL 445
|
|
| NAPRTase_A |
cd01570 |
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate ... |
9-331 |
0e+00 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria and eukaryota (except funghi).
Pssm-ID: 238804 [Multi-domain] Cd Length: 327 Bit Score: 540.24 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 9 LHTDLYQINMMQVYFNQGIHNKKAVFEVYFRQLPFKNGFAVFAGLERIVNYLESLTFSETDIAYLKDLG-YPEDFLDYLA 87
Cdd:cd01570 2 LLTDLYQLTMAQAYWKEGKHNKPAVFELFFRKLPFGGGYAVFAGLEELLEYLENFRFTEEDIDYLRSLGiFDEEFLDYLR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 88 NLKLELTINSALEGDLVFANEPIFQVEGPLAQCQLVETALLNILNYQILIATKAARIRSVIEDAPLLEFGTRRAQEMDAA 167
Cdd:cd01570 82 GFRFTGTIYAIPEGEVVFPNEPLLTVEGPLIEAQLLETLLLNLINFQTLIATKAARVRLAAGGRPLLEFGLRRAQGPDAA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 168 IWGTRAAVIGGADATSNVRAGKIFGIPVSGTHAHALVQAYGNDYDAFKAYASTHKD-CVFLVDTYDTLKIGVPNAIRVAK 246
Cdd:cd01570 162 LSAARAAYIGGFDGTSNVLAGKLYGIPVSGTMAHSFVQAFDDELAAFRAFAEAYPDnFTLLVDTYDTLRSGLPNAIAVAK 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 247 ELGDK-INFLGVRLDSGDLAYLSKQVRKQLDAAGFPDAKIYASNDLDENTILNLKMQKAKIDVWGVGTKLITAYDQPALG 325
Cdd:cd01570 242 ELGALgYRLVGVRIDSGDLAYLSKEARKMLDEAGLTKVKIVASNDLDEYTIAALNAQGAPIDAFGVGTRLVTSQSQPALG 321
|
....*.
gi 1937373633 326 AVYKIV 331
Cdd:cd01570 322 GVYKLV 327
|
|
| PRK12484 |
PRK12484 |
nicotinate phosphoribosyltransferase; Provisional |
4-476 |
4.09e-164 |
|
nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 237112 [Multi-domain] Cd Length: 443 Bit Score: 471.15 E-value: 4.09e-164
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 4 DDSLTLHTDLYQINMMQVYFNQGIhNKKAVFEVYFRQLPFKNGFAVFAGLERIVNYLESLTFSETDIAYLKDL-GYPEDF 82
Cdd:PRK12484 1 QRNLALLTDLYEVTMANAYLREGM-SAPATFSLFYRKLPDGRGFLIAAGLADVVEFLEAFRFDEQDLRYLRGLnQFSEEF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 83 LDYLANLKLELTINSALEGDLVFANEPIFQVEGPLAQCQLVETALLNILNYQILIATKAARIRSVIEDAPLLEFGTRRAQ 162
Cdd:PRK12484 80 LAWLAGLRFTGDVRAVPEGTVVFPNEPLLEVTAPLIEAQLVETFLLNQINHQSLIASKAARCVLAAAGRPVVDFGARRAH 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 163 EMDAAIWGTRAAVIGGADATSNVRAGKIFGIPVSGTHAHALVQAYGNDYDAFKAYASTHKD-CVFLVDTYDTLKiGVPNA 241
Cdd:PRK12484 160 GTDAACYVARASYLAGAAGTSNVLAARQYGIPASGTMAHSFVEAFPDEVAAFRAFARLYPDaTTLLVDTYDTLR-GVRNA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 242 IRVAKELGDKINFLGVRLDSGDLAYLSKQVRKQLDAAGFPDAKIYASNDLDENTILNLKMQKAKIDVWGVGTKLITAYDQ 321
Cdd:PRK12484 239 IEVAKELGNRFDPRGVRLDSGDLAELSKATRAILDAAGLEQVKIVASGGLDEYRIAALLAAGAPIDGFGVGTRLGVAADA 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 322 PALGAVYKIVSIEDNqGVMhdtiKLSnnAEKVSTPGKKQVWRITsrAKGKSEGDYITFADTDVNAldeinmfhptytyin 401
Cdd:PRK12484 319 PVLDSAYKLVAYEGR-GVT----KLS--SGKVTYPGRKQVFRLY--EHGTACGDVIGLHTENIPD--------------- 374
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1937373633 402 ktvrdfDAVPLLVPIYDKGQLIYDLPSLDEIKAYATKELDELWNEYKRVLNPQDYPVDLAKDVWDNKMTLIDNVR 476
Cdd:PRK12484 375 ------GREPLLVPVMTNGRRIQHAPTLDGARDWCEAQLAALPPEARRLVDPVAVSVTLSGELARLRHADTAEAH 443
|
|
| NAPRTase_PncB |
cd01567 |
Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase ... |
9-329 |
1.07e-117 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products.
Pssm-ID: 238801 [Multi-domain] Cd Length: 343 Bit Score: 349.26 E-value: 1.07e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 9 LHTDLYQINMMQVYFNqGIHNKKAVFEVYFRQLPFKNGFAVFAGLERIVNYLESLTFSETDIAYLKDLGY-PEDFLDYLA 87
Cdd:cd01567 2 LDTDLYKLTMMQAYLY-PYPNTRVVFEFTFRSNPFGGDYIVFAGLEEVLKLLENLRFTEEEIEYLKKLLIfGEFFLYLLF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 88 NLKLELTINSALEGDLVFANEPIFQVEGPLAQCQLVETALLNILNYQILIATKAARIRSVIEDA------------PLLE 155
Cdd:cd01567 81 LGKLPLEIYALPEGTVVFPKEPLLTIEGPWPEAGLLETPLLAIWNEATSIATKAARKKLAAGGLletkdnleelgfKLHD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 156 FGTRRAQEMDAAIWGTRAAVIGGADATSNVRAGKIFGIPVSGTHAHALVQAYGND-YDAFKAYASTHKD-----CVFLVD 229
Cdd:cd01567 161 FGTRRRHSPEAALSGGRAALIGGFGGTSNVAAAKKLGIPPIGTMAHSWIQAFGALeEAAFEAFARWLPQfggglGIALID 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 230 TYDTLKiGVPNAIRVAKELGDKINFLGVRLDSGDLAYLSKQVRKQLDAAGF--PDAKIYASNDLD-ENTILNLKMQKAK- 305
Cdd:cd01567 241 TYDTDN-GFLNALKLAKALGAGGGLLGVRLDSGDPVELIKKVRKHLDELGIdlNKKKIIISGDLDtEEAIELLLEQGASp 319
|
330 340
....*....|....*....|....
gi 1937373633 306 IDVWGVGTKLITAYDQPALGAVYK 329
Cdd:cd01567 320 NDAFGVGTSLTNDLGRPPLGFVYK 343
|
|
| PLN02885 |
PLN02885 |
nicotinate phosphoribosyltransferase |
9-466 |
9.88e-117 |
|
nicotinate phosphoribosyltransferase
Pssm-ID: 178473 [Multi-domain] Cd Length: 545 Bit Score: 353.58 E-value: 9.88e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 9 LHTDLYQINMMQVYFNQGIHNKKAVFEVYFRQLPFKNGFAVFAGLERIVNYLESLTFSETDIAYLKD--LGYPED-FLDY 85
Cdd:PLN02885 13 LLTDLYQFTMAYAYWKAGKHLDRAVFDLFFRKNPFGGEYTVFAGLEECLRFIANFKFTDDDIDFLRSvmPSGCEDaFFDY 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 86 LANLKL-ELTINSALEGDLVFANEPIFQVEGPLAQCQLVETALLNILNYQILIATKAARIRSVI-EDAPLLEFGTRRAQE 163
Cdd:PLN02885 93 LRGLDCsDVEVYAIPEGSVVFPRVPLMRIEGPLAVVQLLETTFLTLVNYASLVATNAARHRLVAgKSKVLLEFGLRRAQG 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 164 MDAAIWGTRAAVIGGADATSNVRAGKIFGIPVSGTHAHALVQAY------------------------------------ 207
Cdd:PLN02885 173 PDGGISASKYCYLGGFDATSNVEAGRLFGIPVRGTHSHAFVSSYmgldeivdktlrsadgssvcedfvslvqewlsklqe 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 208 ----------GNDYD--AFKAYA-STHKDCVFLVDTYDTLKIGVPNAIRVA---KELGDKInfLGVRLDSGDLAYLSKQV 271
Cdd:PLN02885 253 ssslrgvfseTNQSElaAFTSYAlAFPNSFLALVDTYDVMKSGIPNFCAVAlalNDLGYKA--VGIRLDSGDLAYLSLEA 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 272 RK-------QLDAAGFPDAKIYASNDLDENTILNLKMQKAKIDVWGVGTKLITAYDQPALGAVYKIVSIEDnqgvmHDTI 344
Cdd:PLN02885 331 RKffrtieeELGVPGFGKMSITASNDINEETLDALNKQGHEIDAFGIGTHLVTCYAQPALGCVYKLVEING-----QPRI 405
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 345 KLSNNAEKVSTPGKKQVWRITSRAkGKSEGDYITFADTDVNALDE-INMFHPtytyINKTVRDFdAVP-----LLVPIYD 418
Cdd:PLN02885 406 KLSEDVEKVTIPCKKRCYRLYGKE-GYPLVDLMTGENEPPPKVGErILCRHP----FNESKRAY-VVPqrveeLLKCYWD 479
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|
gi 1937373633 419 --KGQLIYDLPSLDEIKAYATKELDELWNEYKRVLNPQDYPVDLAKDVWD 466
Cdd:PLN02885 480 gsSGKPREELPSLKEIRERCMKQLERMRPDHMRRLNPTPYKVSVSAKLYD 529
|
|
| PRTase_typeII |
cd00516 |
Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an ... |
12-329 |
4.41e-72 |
|
Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate phosphoribosyltransferase (NAPRTase), to be used in the synthesis of NAD. QAPRTase catalyses the reaction of quinolinic acid (QA) with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to produce nicotinic acid mononucleotide (NAMN), pyrophosphate and carbon dioxide, an important step in the de novo synthesis of NAD. NAPRTase catalyses a similar reaction leading to NAMN and pyrophosphate, using nicotinic acid an PPRP as substrates, used in the NAD salvage pathway.
Pssm-ID: 238286 [Multi-domain] Cd Length: 281 Bit Score: 229.82 E-value: 4.41e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 12 DLYQINMMQVYfnqGIHNKKAVFEVYFRQLPFkngfAVFAGLERIVNYLESLtfsetdiaylkdlgypeDFLDYLANLKL 91
Cdd:cd00516 1 DLYKLTMIQAY---PPPDTRATAEFTAREDPY----GVLAGLEEALELLELL-----------------RFPGPLVILAV 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 92 EltinsalEGDLVFANEPIFQVEGPLAQCQLVETALLNILNYQILIATKAARIRSVIEDA--PLLEFGTRRAQEmDAAIW 169
Cdd:cd00516 57 P-------EGTVVEPGEPLLTIEGPARELLLLERVLLNLLQRLSGIATATARYVEAAKGAntKVHDFGTRKTTP-GLRLL 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 170 GTRAAVIGGADATSNVRAGKIFGIPVSGTHAHALVQAYGNDyDAFKAYASTH-KDCVFLVDTYDTLkigVPNAIRVAKEL 248
Cdd:cd00516 129 EKYAVLIGGGDGHRNGLSDAILIKDNHGTMAHSIIQAFGEL-AAVKALRRWLpELFIALIDVEVDT---LEEALEAAKAG 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 249 GdkinFLGVRLDSG-----DLAYLSKQVRKQLDAAGFPDAKIYASNDLDENTILNLKmqKAKIDVWGVGTKLITAydqPA 323
Cdd:cd00516 205 G----ADGIRLDSGspeelDPAVLILKARAHLDGKGLPRVKIEASGGLDEENIRAYA--ETGVDVFGVGTLLHSA---PP 275
|
....*.
gi 1937373633 324 LGAVYK 329
Cdd:cd00516 276 LDIVLK 281
|
|
| PRK08662 |
PRK08662 |
nicotinate phosphoribosyltransferase; Reviewed |
11-313 |
9.95e-52 |
|
nicotinate phosphoribosyltransferase; Reviewed
Pssm-ID: 236328 [Multi-domain] Cd Length: 343 Bit Score: 178.53 E-value: 9.95e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 11 TDLYQINMMQVYFNQGIhNKKAVFEVYFRQLPfKNGFAVFAGLERIVNYLESLtfsetdiaylkdlgypedfldylanlk 90
Cdd:PRK08662 18 TDIYFERTVEILEHAGK-NPKVVAEVTASSLP-KGEWGVFAGLEEVLELLEGK--------------------------- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 91 lELTINSALEGDLVFANEPIFQVEGPLAQCQLVETALLNILNYQILIATKAARIRSVIEDAPLLEFGTRRaqeMDAAIWG 170
Cdd:PRK08662 69 -PVDVYALPEGTLFDPKEPVMRIEGPYLEFGIYETALLGILAHASGIATAAARCKEAAGDKPVLSFGARH---VHPAIAP 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 171 T--RAAVIGGADATSNVRAGKIFGIPVSGTHAHALVQAYGNDYDAFKAYASTHKDCV---FLVDTYdtlKIGVPNAIRVA 245
Cdd:PRK08662 145 MmdRAAYIGGCDGVSGVLGAELLGIEPSGTMPHALILIFGDQVEAWKAFDEVVPPDVpriALVDTF---KDEREEALRAA 221
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1937373633 246 KELGDKINflGVRLDS-----GDLAYLSKQVRKQLDAAGFPDAKIYASNDLDENTILNLkmqKAKIDVWGVGT 313
Cdd:PRK08662 222 EALGDRLD--GVRLDTpssrrGNFRKIVREVRWTLDIRGYEHVKIFVSGGLDPERIREL---RDVVDGFGVGT 289
|
|
| NAPRTase_B |
cd01571 |
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate ... |
11-318 |
7.92e-50 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products.
Pssm-ID: 238805 [Multi-domain] Cd Length: 302 Bit Score: 172.46 E-value: 7.92e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 11 TDLYQINMMQVYFNQGiHNKKAVFEVYFRQLPFkngfAVFAGLERIVNYLEsltFSETDIAYLKdlgypedfldylanlk 90
Cdd:cd01571 4 TDVYFLRTRKILEKKG-PNPTVTMEFTQRSLPW----AVLCGLEEVLALLE---GLPVKVYALP---------------- 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 91 leltinsalEGDLVFANEPIFQVEGPLAQCQLVETALLNILNYQILIATKAARIRSVIEDAPLLEFGTRR----AQEMDA 166
Cdd:cd01571 60 ---------EGTIFNPKEPVLRIEGPYQDFGELETAILGILARASSIATNAARVKLAAGDKPVISFGDRRdhpaIQPMDG 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 167 aiwgtRAAVIGGADATSNVRAGKIFGIPVSGTHAHALVQAYGNDYD-AFKAYASTH---KDCVFLVDTYDTLKIGvpnAI 242
Cdd:cd01571 131 -----RAAYIGGCDGVSTVLGAELLGEKPSGTMPHALIQIFGGDQVeAWKAFDETYpedVPRIALIDTFNDEKEE---AL 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 243 RVAKELGDKINflGVRLDS-----GDLAYLSKQVRKQLDAAGFPDAKIYASNDLDENTILNLKmqKAKIDVWGVGTKLIT 317
Cdd:cd01571 203 KAAKALGDKLD--GVRLDTpssrrGVFRYLIREVRWALDIRGYKHVKIFVSGGLDEEDIKELE--DVGVDAFGVGTAISK 278
|
.
gi 1937373633 318 A 318
Cdd:cd01571 279 A 279
|
|
| NAPRTase_N |
pfam17767 |
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate ... |
9-132 |
1.64e-44 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This is the N-terminal domain of the enzyme.
Pssm-ID: 465494 [Multi-domain] Cd Length: 125 Bit Score: 152.28 E-value: 1.64e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 9 LHTDLYQINMMQVYFNQGIhNKKAVFEVYFRQLPFKNGFAVFAGLERIVNYLESLTFSETDIAYLKD-LGY-PEDFLDYL 86
Cdd:pfam17767 1 LDTDLYKLTMAQAYFKNGP-DVQVVFEFFNRTNPFGGLYAVFAGLEEQIEFLENLRFTEEEIEYLRRsLPYfKPDFLDYL 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1937373633 87 ANLKLELTINSALEGDLVFANEPIFQVEGPLAQCQLVETALLNILN 132
Cdd:pfam17767 80 RNFRFDPSIVAVPEGEVVFPGEPLLRIEGPWLETILLETPLLAIVN 125
|
|
| NAPRTase_C |
pfam17956 |
Nicotinate phosphoribosyltransferase C-terminal domain; This domain is found at the C-terminus ... |
358-468 |
1.09e-35 |
|
Nicotinate phosphoribosyltransferase C-terminal domain; This domain is found at the C-terminus of some Nicotinate phosphoribosyltransferase enzymes. The function of this domain is uncertain.
Pssm-ID: 465585 [Multi-domain] Cd Length: 111 Bit Score: 128.07 E-value: 1.09e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 358 KKQVWRITSRAkGKSEGDYITFAD-TDVNALDEINMFHPTYTYINKTVRDFDAVPLLVPIYDKGQLIYDLPSLDEIKAYA 436
Cdd:pfam17956 1 RKQVYRLYDKD-GKAIADLITLADePPPDPGEEILCFHPFDEWKRKTVTPFTVEPLLKPVFEDGKLVYELPTLEEIRAYV 79
|
90 100 110
....*....|....*....|....*....|..
gi 1937373633 437 TKELDELWNEYKRVLNPQDYPVDLAKDVWDNK 468
Cdd:pfam17956 80 QEQLSRLWPEHKRLLNPHPYKVDLSEKLYQLK 111
|
|
| PRK07188 |
PRK07188 |
nicotinate phosphoribosyltransferase; Provisional |
92-316 |
3.41e-18 |
|
nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 235953 [Multi-domain] Cd Length: 352 Bit Score: 85.77 E-value: 3.41e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 92 ELTINSALEGDLVFANEPIFQVEGPLAQCQLVETALLNILNYQILIATKAARIRSVIEDAPLLEFGTRRAQEMDAAIWGt 171
Cdd:PRK07188 71 KLKIRYLKDGDIINPFETVLEIEGPYENFGFLEGIIDGILARRTSVATNAYNVVQAANEKPVIFMGDRADHYLQQAGDG- 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 172 RAAVIGGADATSNVRAGKIFGIPVSGTHAHALVQAYGNDYD-AFKAYAST--HKDCVFLVDtYDTLKIGvpNAIRVAKEL 248
Cdd:PRK07188 150 YAAYIGGISAFSTHAQNEWWGKSGFGTMPHALIQMFNGDVVeACKAYHKTfpEDELIALVD-YNNDVIT--DSLKVAREF 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 249 GDKINflGVRLD-SGDLA---------------------YLSKQVRKQLDAAGFPDAKIYASNDLDENTILNLKMQKAKI 306
Cdd:PRK07188 227 GDKLK--GVRVDtSKNMIdkyfirhpevlgtfdprgvnpELIKALRKALDENGGKHVKIIVSSGFDAKKIREFEAQNVPV 304
|
250
....*....|
gi 1937373633 307 DVWGVGTKLI 316
Cdd:PRK07188 305 DIYGVGSSLL 314
|
|
| PRK05321 |
PRK05321 |
nicotinate phosphoribosyltransferase; Provisional |
6-352 |
1.11e-17 |
|
nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 235406 [Multi-domain] Cd Length: 400 Bit Score: 84.81 E-value: 1.11e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 6 SLtLHTDLYQINMMQVYFnqgiHNKKAVfEVYFRqlpFKN-GFAVFAG-----LERIVNYLESLTFSETDIAYLKDLGY- 78
Cdd:PRK05321 11 SL-LDTDFYKLTMQQAVL----HHYPDA-QVEYE---FICrNDEVDLAeyideIREQLDHLCTLRLTDDELDYLRGLPFf 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 79 PEDFLDYLANLKL---ELTInSALEGDLVFAnepifqVEGPLAQCQLVETALLNILN--------YQILIA-------TK 140
Cdd:PRK05321 82 KPDFLDWLRLFRLnpyEVTV-SIDDGQLDIR------IEGPWLETILWEVPLLAIISelyfrarsPEVLYAqakrrlwEK 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 141 AARIRSVIEDAPLL--EFGTRR-----AQE--MDAAIWGTRAAVIGgadaTSNVRAGKIFGIPVSGTHAHALVQAYG--- 208
Cdd:PRK05321 155 IELLKALPDLSGFKiaDFGTRRrfsfeWQEevVEALKEGLPGAFVG----TSNVHLAMKLGLTPIGTMAHEWFMAHQalg 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 209 -----NDYDAFKAYASTHKD--CVFLVDTYDT---LKigvPNAIRVAKelgdkiNFLGVRLDSGD-LAYLSKQVR--KQL 275
Cdd:PRK05321 231 prlrdSQYAALEDWVREYRGdlGIALTDTIGMdafLR---DFDLYFAK------LFDGLRHDSGDpIEWGEKAIAhyEKL 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 276 DAagfpDAK---IYASNDLDENTILNLKMQ-KAKIDV-WGVGTKL---ITAYdqPALGAVYKIVSIEdnqgvMHDTIKLS 347
Cdd:PRK05321 302 GI----DPRtktLVFSDGLDFDKALELYRHfKGRIKLsFGIGTNLtndFPGV--KPLNIVIKLVECN-----GRPVAKLS 370
|
....*
gi 1937373633 348 NNAEK 352
Cdd:PRK05321 371 DSPGK 375
|
|
| PncB_like |
cd01401 |
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate ... |
9-352 |
2.33e-16 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria, archea and funghi.
Pssm-ID: 238695 [Multi-domain] Cd Length: 377 Bit Score: 80.37 E-value: 2.33e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 9 LHTDLYQINMMQVYFnqgiHNKKAVfEVYFRqlpFKN-GFAVFAG--LERI---VNYLESLTFSETDIAYLKD-LGY-PE 80
Cdd:cd01401 4 LDTDLYKLTMQQAVL----HHYPDV-QVTYE---FTNrSPEDFLEeaAEALreqIDHLANLRFSEEELAYLRRsLPFlKP 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 81 DFLDYLANLKL---ELTI-NSALEGDLVFanepifQVEGPLAQCQLVETALLNILN--Y------------QILIA-TKA 141
Cdd:cd01401 76 DYLDYLELFRLnpeEVVVrLDTGKGQLDI------RISGPWKDTILYEVPLLAIVSevYfrfrdadwdyeeQLEKLeEKL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 142 ARIRSVIEDAPL-----LEFGTRR-----AQE--MDAAIWGTRAAVIGgadaTSNVRAGKIFGIPVSGTHAHALVQAY-- 207
Cdd:cd01401 150 ERLLEEAKRRDLngfrfSDFGTRRrfsyeVQEtvLKGLKQAAPGYLTG----TSNVHFAMKYGLTPIGTVAHEWFMAHqa 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 208 -GNDYD-----AFKAYASTHKD--CVFLVDTYDT---LKIGVPNairVAKElgdkinFLGVRLDSGDLAYLSKQVRKQLD 276
Cdd:cd01401 226 lTGDLKdsqkaALERWVREYGGdlGIALTDTFGTdafLRDFDLY---FAKL------FDGVRHDSGDPFEWGEKAIAHYE 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 277 AAGF-PDAK-IYASNDLDENTILNLKMQ-KAKIDV-WGVGTKL-----ITAYDQPaLGAVYKIVSIEDnqgvmHDTIKLS 347
Cdd:cd01401 297 KLGIdPKTKtLVFSDGLDVEKALELYEYfKGRIKVsFGIGTNLtndfgNKEKSTP-LNIVIKLVECNG-----RPVAKIS 370
|
....*
gi 1937373633 348 NNAEK 352
Cdd:cd01401 371 DSPGK 375
|
|
| NAPRTase |
TIGR01514 |
nicotinate phosphoribosyltransferase; This model represents nicotinate ... |
9-352 |
6.03e-13 |
|
nicotinate phosphoribosyltransferase; This model represents nicotinate phosphoribosyltransferase, the first enzyme in the salvage pathway of NAD biosynthesis from nicontinate (niacin). Members are primary proteobacterial but also include yeasts and Methanosarcina acetivorans. A related family, apparently non-overlapping in species distribution, is TIGR01513. Members of that family differ in substantially in sequence and have a long C-terminal extension missing from this family, but are proposed also to act as nicotinate phosphoribosyltransferase (see model TIGR01513). [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Pssm-ID: 130578 [Multi-domain] Cd Length: 394 Bit Score: 70.17 E-value: 6.03e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 9 LHTDLYQINMMQVYFNQ--GIHNKkAVFEVYFRQLPFKnGFAvfAGLERIVNYLESLTFSETDIAYLK-DLGY-PEDFLD 84
Cdd:TIGR01514 6 LDTDLYKITMHQAVFHNfpDVHVT-YEFICRSSQLFLK-EAA--EALREEISALGNLRFTDDEIEYLKqELPYlKSDYID 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 85 YLANLKL----ELTINSALEGDLVFanepifQVEGPLAQCQLVETALLNILN---YQILIA------------TKAARIR 145
Cdd:TIGR01514 82 YLRNFRFhpeeQVEVGIDDKGKLDI------RISGSWRDTILYEIPLLAIISelyFRFRDAeadyeqqlevleSKLDQLK 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 146 SVIE-------DAPLLEFGTRR---AQEMDAAIWGTRAAVIGGADATSNVRAGKIFGIPVSGTHAHALVQAYGN------ 209
Cdd:TIGR01514 156 AEIAaetmfenGFRFSEFGTRRrfsLEVQDLVTQGLKQAAPSWLLGTSNVHLAKKLGLKPIGTVAHEWFQGHQAiseyrn 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 210 -DYDAFKAYASTHKD--CVFLVDTYDT---LK-IGVPNAIRvakelgdkinFLGVRLDSGD-LAYLSKQVRKQLDAAGFP 281
Cdd:TIGR01514 236 aQKVALECWINEYDGdlGIALTDTFTTdafLRdFRPPFADA----------YDGLRHDSGDpVEWGDKAIAHYQKLGIDP 305
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1937373633 282 DAKIYA-SNDLD-ENTILNLKMQKAKIDV-WGVGTKLITAYDQ-PALGAVYKIVSIEdnqgvMHDTIKLSNNAEK 352
Cdd:TIGR01514 306 KSKIIIfSDSLDvEKAIELSHYFKGRVKAsFGIGTNLTNDFGKvEPLNIVIKLVECN-----GNPVAKLSDSPGK 375
|
|
| NAPRTase |
pfam04095 |
Nicotinate phosphoribosyltransferase (NAPRTase) family; Nicotinate phosphoribosyltransferase ... |
153-329 |
9.68e-07 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) family; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This family also includes Pre-B cell enhancing factor that is a cytokine Swiss:P43490. This family is related to Quinolinate phosphoribosyltransferase pfam01729.
Pssm-ID: 397974 [Multi-domain] Cd Length: 235 Bit Score: 49.69 E-value: 9.68e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 153 LLEFGTRRAQEMDAAIWGTRAA---VIGgadaTSNVRAGKIFGIPVSGTHAHA-----------LVQAYGNDYDAFKAYA 218
Cdd:pfam04095 3 LHDFGTRRRSSLESQEIVGLAHlvnFLG----TSNVHFAAKYSIPPAGTSAHEwwgahqeldanLRQFQKDALDLWHAEY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 219 STH-----KDCVFLVDTYDTLKIGVPNAirvakelgdkinFLGVRLDSGD----LAYLSKQVRKQLDAAGFPDAKIYaSN 289
Cdd:pfam04095 79 RGNlgialTDTVTMDAFLKDFDLYFAKL------------YLGVRPDSGDpvewGEKLIAHYGSTLNIDGYTKRLIF-SD 145
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1937373633 290 DLDENTILNL--KMQKAKIDV-WGVGTKLITAYDQPALGAVYK 329
Cdd:pfam04095 146 GLDVEKIIELleYFKGKGFNIaFGIGTNLTQDLNRDTLGFAVK 188
|
|
| PRK09198 |
PRK09198 |
putative nicotinate phosphoribosyltransferase; Provisional |
46-436 |
7.95e-05 |
|
putative nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 236407 [Multi-domain] Cd Length: 463 Bit Score: 44.89 E-value: 7.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 46 GFAVFAGLERIV-NYLESLtFSETDIAYLKDL----GYP---EDFLDYLANL--KLELTINSALEGDLVFANEPIFQVEG 115
Cdd:PRK09198 42 DKVVFFGLQYFLkEYLIQP-ITEAFIDEAKALlvahGLPfnrAGWRRIVDKYggYLPLRIKAVPEGSVVPVHNVLMTIEN 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 116 PLAQC----QLVETALLNILNYQILIATKAARIRSVIEDAPLL-------------EFGTRRAQemdaaiwGTRAAVIGG 178
Cdd:PRK09198 121 TDPEFfwlpNYLETLLLRNVWYPSTVATISWEYKQLIRQYLEKtaddldflpfqlhDFGARGMS-------SLESAALGG 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 179 A------DATSNVRAGKI-----------FGIPVSgthAHALVQAYG--NDYDAFK-AYASTHKDCVFLV--DTYDTLki 236
Cdd:PRK09198 194 AahlvsfLGTDTIPALLYaeryynadmagFSIPAT---EHSVMTSWGreGELEAYRnMIEQFYPGGIVSIvsDSYDLW-- 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 237 gvpNAIRVA--KELGDKINFLG----VRLDSGD-----------LAY-------------LSKQVR-------------- 272
Cdd:PRK09198 269 ---NAITEPwgGELKDEILARGgtlvIRPDSGDpvtiicgtlelLDEifggtvnskgykvLNPHVGviqgdgitldsiea 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 273 --KQLDAAGFpdakiyASNDLdentilnlkmqkakidVWGVGTKLITAYDQPALGAVYKIVSIEDNqGVMHDTIKlsnna 350
Cdd:PRK09198 346 ilEALKAKGF------AAENI----------------VFGMGGALLQYVNRDTQGFAMKASAIEVN-GEWRDIFK----- 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 351 EKVSTPGKKQvwritsrAKG-----KSEGDYITFADTDVNAldeinmfhptytyinktvrdfDAVPLLVPIYDKGQLIYD 425
Cdd:PRK09198 398 DPITDQGKKS-------KKGrlkliKDNGEYRTVDLDEAGD---------------------ENDDLLQTVFENGKLLVE 449
|
490
....*....|.
gi 1937373633 426 LpSLDEIKAYA 436
Cdd:PRK09198 450 Y-SLAEIRARL 459
|
|
| modD_like |
cd01573 |
ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC ... |
90-180 |
3.14e-03 |
|
ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and eukaryotes. They catalyse the reaction of quinolinic acid (QA) with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to produce nicotinic acid mononucleotide (NAMN), pyrophosphate and carbon dioxide.
Pssm-ID: 238807 [Multi-domain] Cd Length: 272 Bit Score: 39.59 E-value: 3.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 90 KLELTINSAL-EGDLVFANEPIFQVEGPLAQCQLVETALLNILNYQILIATKAARI----RSViedAPLLEFGTRRaqem 164
Cdd:cd01573 53 LLGLEVDLAAaSGSRVAAGAVLLEAEGPAAALHLGWKVAQTLLEWASGIATATAEMvaaaRAV---NPDIVVATTR---- 125
|
90 100
....*....|....*....|.
gi 1937373633 165 dAAIWGTR-----AAVIGGAD 180
Cdd:cd01573 126 -KAFPGTRklalkAILAGGAV 145
|
|
| QPRTase_NadC |
cd01568 |
Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called ... |
82-180 |
3.56e-03 |
|
Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to produce nicotinic acid mononucleotide (NAMN), pyrophosphate and carbon dioxide. QPRTase functions as a homodimer with two active sites, each formed by the C-terminal region of one subunit and the N-terminal region of the other.
Pssm-ID: 238802 [Multi-domain] Cd Length: 269 Bit Score: 39.38 E-value: 3.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937373633 82 FLDYLANLKLELTINsalEGDLVFANEPIFQVEGPLAQCQLVETALLNILnyQIL--IATKAARIRSVIEDAPLLEFGTR 159
Cdd:cd01568 50 VFELLDGIEVEWLVK---DGDRVEAGQVLLEVEGPARSLLTAERVALNLL--QRLsgIATATRRYVEAARGTKARIADTR 124
|
90 100
....*....|....*....|....*.
gi 1937373633 160 RaqemdaAIWGTR-----AAVIGGAD 180
Cdd:cd01568 125 K------TTPGLRllekyAVRAGGGD 144
|
|
| |
