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Conserved domains on  [gi|1936360303|ref|WP_195874695|]
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glucose-6-phosphate dehydrogenase [Herminiimonas contaminans]

Protein Classification

glucose-6-phosphate dehydrogenase (NADP(+))( domain architecture ID 11417513)

glucose-6-phosphate dehydrogenase (NADP(+)) catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 6-485 0e+00

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


:

Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 848.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303   6 FDLVLFGGGGDLSMRKLIPALYARDRAGDLPATAQIICVGRNERSTAEFIETVNENAKSHINEKtFSQAVWDKFCARIKY 85
Cdd:COG0364    10 CDLVIFGATGDLARRKLLPALYNLYRDGLLPEGFRIIGVARRDWSDEEFREEVREALEEFSRKP-FDEEVWERFLERLHY 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303  86 VALDASDANTYQPLNDALRDSSSV----TRVFYLATPPTLFASICHNLSARGLATE--QTRVVLEKPLGRDLASAKQINQ 159
Cdd:COG0364    89 VSGDFTDPEGYERLKELLEELDEErtpgNRVFYLATPPSLFGPICENLGAAGLATEggWRRVVIEKPFGHDLASARELND 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 160 EVSQVFKESQIYRIDHYLGKEAVQNLLALRFGNVLFEPLWRREWISDVQITIAEEIGVGNRMGYYETSGALRDMMQNHLL 239
Cdd:COG0364   169 ELGRVFDESQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGALRDMVQNHLL 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 240 QLLCIVAMEPPLSVTPDAVRDEKLKVLRSLKPFTQNTLAKNVVRGQYRAGHVNGVAVPAYRQEKTADPDSNTETFVAVKA 319
Cdd:COG0364   249 QLLCLVAMEPPASLDADAIRDEKVKVLRALRPITPEDVAENTVRGQYTAGWIGGEPVPGYREEPGVAPDSTTETFVALKL 328

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 320 EIDTWRWAGVPFYLRTGKRMADQLAEIVVRFKSIPHSIFAQSTSSFQPNCLVIRLQPDDGLQLNLMAKTPGDGMRLKPVE 399
Cdd:COG0364   329 EIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKPVPHSLFRETAEELPPNRLVIRIQPDEGISLRFNAKVPGLGMRLRPVS 408

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 400 LELDFAETFKAPRMDAYERLLLDVLRGQLTLFMRSDELEAAWEWVEPVLRYWEQEGNEPLPYASGTWGPAASSSLIGRDG 479
Cdd:COG0364   409 LDFSYSDAFGERSPEAYERLLLDVMRGDQTLFMRRDEVEAAWRWVDPILEAWAEEPEPPPPYPAGSWGPEAADALLARDG 488


                  ....*.
gi 1936360303 480 LQWREE 485
Cdd:COG0364   489 RSWREP 494
 
Name Accession Description Interval E-value
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 6-485 0e+00

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 848.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303   6 FDLVLFGGGGDLSMRKLIPALYARDRAGDLPATAQIICVGRNERSTAEFIETVNENAKSHINEKtFSQAVWDKFCARIKY 85
Cdd:COG0364    10 CDLVIFGATGDLARRKLLPALYNLYRDGLLPEGFRIIGVARRDWSDEEFREEVREALEEFSRKP-FDEEVWERFLERLHY 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303  86 VALDASDANTYQPLNDALRDSSSV----TRVFYLATPPTLFASICHNLSARGLATE--QTRVVLEKPLGRDLASAKQINQ 159
Cdd:COG0364    89 VSGDFTDPEGYERLKELLEELDEErtpgNRVFYLATPPSLFGPICENLGAAGLATEggWRRVVIEKPFGHDLASARELND 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 160 EVSQVFKESQIYRIDHYLGKEAVQNLLALRFGNVLFEPLWRREWISDVQITIAEEIGVGNRMGYYETSGALRDMMQNHLL 239
Cdd:COG0364   169 ELGRVFDESQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGALRDMVQNHLL 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 240 QLLCIVAMEPPLSVTPDAVRDEKLKVLRSLKPFTQNTLAKNVVRGQYRAGHVNGVAVPAYRQEKTADPDSNTETFVAVKA 319
Cdd:COG0364   249 QLLCLVAMEPPASLDADAIRDEKVKVLRALRPITPEDVAENTVRGQYTAGWIGGEPVPGYREEPGVAPDSTTETFVALKL 328

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 320 EIDTWRWAGVPFYLRTGKRMADQLAEIVVRFKSIPHSIFAQSTSSFQPNCLVIRLQPDDGLQLNLMAKTPGDGMRLKPVE 399
Cdd:COG0364   329 EIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKPVPHSLFRETAEELPPNRLVIRIQPDEGISLRFNAKVPGLGMRLRPVS 408

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 400 LELDFAETFKAPRMDAYERLLLDVLRGQLTLFMRSDELEAAWEWVEPVLRYWEQEGNEPLPYASGTWGPAASSSLIGRDG 479
Cdd:COG0364   409 LDFSYSDAFGERSPEAYERLLLDVMRGDQTLFMRRDEVEAAWRWVDPILEAWAEEPEPPPPYPAGSWGPEAADALLARDG 488


                  ....*.
gi 1936360303 480 LQWREE 485
Cdd:COG0364   489 RSWREP 494
PRK05722 PRK05722
glucose-6-phosphate 1-dehydrogenase; Validated
 6-485 0e+00

glucose-6-phosphate 1-dehydrogenase; Validated


Pssm-ID: 235579 [Multi-domain]  Cd Length: 495  Bit Score: 805.89  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303   6 FDLVLFGGGGDLSMRKLIPALYARDRAGDLPATAQIICVGRNERSTAEFIETVNENAKSHINEKtFSQAVWDKFCARIKY 85
Cdd:PRK05722   10 CDLVIFGATGDLARRKLLPALYNLYKAGLLPEDFRIIGVARRDWSDEDFREVVREALKEFARTP-FDEEVWERFLSRLYY 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303  86 VALDASDANTYQPLNDALRD-----SSSVTRVFYLATPPTLFASICHNLSARGLATEQ--TRVVLEKPLGRDLASAKQIN 158
Cdd:PRK05722   89 VSGDVTDPESYERLKELLEEldeerGTGGNRVFYLATPPSLFGTICENLAAAGLNEGGgwRRVVIEKPFGHDLASARELN 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 159 QEVSQVFKESQIYRIDHYLGKEAVQNLLALRFGNVLFEPLWRREWISDVQITIAEEIGVGNRMGYYETSGALRDMMQNHL 238
Cdd:PRK05722  169 DQVGEVFKEEQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDKSGALRDMVQNHL 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 239 LQLLCIVAMEPPLSVTPDAVRDEKLKVLRSLKPFTQNTLAKNVVRGQYRAGHVNGVAVPAYRQEKTADPDSNTETFVAVK 318
Cdd:PRK05722  249 LQLLALVAMEPPASLDADSIRDEKVKVLRALRPITPEDVKENTVRGQYTAGWIGGKPVPGYREEEGVNPDSTTETFVALK 328

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 319 AEIDTWRWAGVPFYLRTGKRMADQLAEIVVRFKSIPHSIFAQSTSSFQPNCLVIRLQPDDGLQLNLMAKTPGDGMRLKPV 398
Cdd:PRK05722  329 LEIDNWRWAGVPFYLRTGKRLPKKVTEIVIVFKPPPHNLFEESAEELGPNKLVIRIQPDEGISLRFNAKVPGEGMELRPV 408

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 399 ELELDFAETFKAPRMDAYERLLLDVLRGQLTLFMRSDELEAAWEWVEPVLRYWEQEGNEPLPYASGTWGPAASSSLIGRD 478
Cdd:PRK05722  409 KLDFSYSEAFGEASPEAYERLLLDVMLGDQTLFVRRDEVEAAWKWVDPILEAWEADGGPPPPYPAGTWGPEAADALLARD 488


                  ....*..
gi 1936360303 479 GLQWREE 485
Cdd:PRK05722  489 GRSWREP 495
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 5-484 0e+00

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 625.88  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303   5 DFDLVLFGGGGDLSMRKLIPALYARDRAGDLPATAQIICVGRNERSTAEFIETVNEnAKSHINEKTFSQAvWDKFCARIK 84
Cdd:TIGR00871   2 PCILVIFGASGDLARKKLFPALYRLFRNGLLPPDFRIVGVARRDWSVEEFRKVVRE-AIIKFETDEIDEQ-WDEFAQRLS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303  85 YVALDASDANTYQPLNDALRDS-----SSVTRVFYLATPPTLFASICHNLSARGLATE--QTRVVLEKPLGRDLASAKQI 157
Cdd:TIGR00871  80 YVSGDVDDDESYDSLAELLEQLdktygTEGNRLFYLATPPSLFGTIIKQLKKHGLNEQgkWSRVVVEKPFGHDLASAQEL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 158 NQEVSQVFKESQIYRIDHYLGKEAVQNLLALRFGNVLFEPLWRREWISDVQITIAEEIGVGNRMGYYETSGALRDMMQNH 237
Cdd:TIGR00871 160 NKALRAVFKEDQIYRIDHYLGKETVQNLLVLRFANQIFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGALRDMVQNH 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 238 LLQLLCIVAMEPPLSVTPDAVRDEKLKVLRSLKPFTqnTLAKNVVRGQYRAGHVNGVAVPAYRQEKTADPDSNTETFVAV 317
Cdd:TIGR00871 240 LLQLLALVAMEPPVSFDADSIRDEKVKVLKALRPID--PDDNNTVRGQYGAGEIGGVSVPGYLEEEGVDKDSNTETFAAL 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 318 KAEIDTWRWAGVPFYLRTGKRMADQLAEIVVRFKSIPHSIFAQSTSSFQP-NCLVIRLQPDDGLQLNLMAKTPGDGMRLK 396
Cdd:TIGR00871 318 KLEIDNWRWAGVPFYLRTGKRLPEKVTEIRIQFRDVPSLLFKANERDANPrNALVIRIQPDEGVYLKFNAKKPGLNFETR 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 397 PVELELDFAETFKAPRMDAYERLLLDVLRGQLTLFMRSDELEAAWEWVEPVLRYWEQEGNE-PLPYASGTWGPAASSSLI 475
Cdd:TIGR00871 398 PVKLDFSYASRFGELLPEAYERLLLDALLGDHTLFARDDEVEEAWRIVTPILEAWAANKGPsPPNYPAGSWGPKEADELI 477


                  ....*....
gi 1936360303 476 GRDGLQWRE 484
Cdd:TIGR00871 478 RKDGRSWRK 486
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
186-483 0e+00

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 525.08  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 186 LALRFGNVLFEPLWRREWISDVQITIAEEIGVGNRMGYYETSGALRDMMQNHLLQLLCIVAMEPPLSVTPDAVRDEKLKV 265
Cdd:pfam02781   1 LVLRFANAIFEPLWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAMEPPVSFDAEDIRDEKVKV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 266 LRSLKPFTQNTLAKNVVRGQYRAGHVNGVAVPAYRQEKTADPDSNTETFVAVKAEIDTWRWAGVPFYLRTGKRMADQLAE 345
Cdd:pfam02781  81 LRSLRPITPEDVEDNVVRGQYGAGWIGGEPVPGYREEEGVPPDSRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERVTE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 346 IVVRFKSIPHSIFAQStSSFQPNCLVIRLQPDDGLQLNLMAKTPGDGMRLKPVELELDFAETFKAPRMDAYERLLLDVLR 425
Cdd:pfam02781 161 IRIQFKDVPHNLFRDP-GTLPPNELVIRIQPDEGIYLKFNAKVPGLGMRLRPVELDFSYSDRFGERIPEAYERLLLDVMR 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1936360303 426 GQLTLFMRSDELEAAWEWVEPVLRYWEQEgnEPLPYASGTWGPAASSSLIGRDGLQWR 483
Cdd:pfam02781 240 GDQTLFVRSDEVEAAWRIVDPILEAWDEE--KPPPYPAGSWGPKAADELLARDGRKWR 295
 
Name Accession Description Interval E-value
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 6-485 0e+00

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 848.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303   6 FDLVLFGGGGDLSMRKLIPALYARDRAGDLPATAQIICVGRNERSTAEFIETVNENAKSHINEKtFSQAVWDKFCARIKY 85
Cdd:COG0364    10 CDLVIFGATGDLARRKLLPALYNLYRDGLLPEGFRIIGVARRDWSDEEFREEVREALEEFSRKP-FDEEVWERFLERLHY 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303  86 VALDASDANTYQPLNDALRDSSSV----TRVFYLATPPTLFASICHNLSARGLATE--QTRVVLEKPLGRDLASAKQINQ 159
Cdd:COG0364    89 VSGDFTDPEGYERLKELLEELDEErtpgNRVFYLATPPSLFGPICENLGAAGLATEggWRRVVIEKPFGHDLASARELND 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 160 EVSQVFKESQIYRIDHYLGKEAVQNLLALRFGNVLFEPLWRREWISDVQITIAEEIGVGNRMGYYETSGALRDMMQNHLL 239
Cdd:COG0364   169 ELGRVFDESQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGALRDMVQNHLL 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 240 QLLCIVAMEPPLSVTPDAVRDEKLKVLRSLKPFTQNTLAKNVVRGQYRAGHVNGVAVPAYRQEKTADPDSNTETFVAVKA 319
Cdd:COG0364   249 QLLCLVAMEPPASLDADAIRDEKVKVLRALRPITPEDVAENTVRGQYTAGWIGGEPVPGYREEPGVAPDSTTETFVALKL 328

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 320 EIDTWRWAGVPFYLRTGKRMADQLAEIVVRFKSIPHSIFAQSTSSFQPNCLVIRLQPDDGLQLNLMAKTPGDGMRLKPVE 399
Cdd:COG0364   329 EIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKPVPHSLFRETAEELPPNRLVIRIQPDEGISLRFNAKVPGLGMRLRPVS 408

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 400 LELDFAETFKAPRMDAYERLLLDVLRGQLTLFMRSDELEAAWEWVEPVLRYWEQEGNEPLPYASGTWGPAASSSLIGRDG 479
Cdd:COG0364   409 LDFSYSDAFGERSPEAYERLLLDVMRGDQTLFMRRDEVEAAWRWVDPILEAWAEEPEPPPPYPAGSWGPEAADALLARDG 488


                  ....*.
gi 1936360303 480 LQWREE 485
Cdd:COG0364   489 RSWREP 494
PRK05722 PRK05722
glucose-6-phosphate 1-dehydrogenase; Validated
 6-485 0e+00

glucose-6-phosphate 1-dehydrogenase; Validated


Pssm-ID: 235579 [Multi-domain]  Cd Length: 495  Bit Score: 805.89  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303   6 FDLVLFGGGGDLSMRKLIPALYARDRAGDLPATAQIICVGRNERSTAEFIETVNENAKSHINEKtFSQAVWDKFCARIKY 85
Cdd:PRK05722   10 CDLVIFGATGDLARRKLLPALYNLYKAGLLPEDFRIIGVARRDWSDEDFREVVREALKEFARTP-FDEEVWERFLSRLYY 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303  86 VALDASDANTYQPLNDALRD-----SSSVTRVFYLATPPTLFASICHNLSARGLATEQ--TRVVLEKPLGRDLASAKQIN 158
Cdd:PRK05722   89 VSGDVTDPESYERLKELLEEldeerGTGGNRVFYLATPPSLFGTICENLAAAGLNEGGgwRRVVIEKPFGHDLASARELN 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 159 QEVSQVFKESQIYRIDHYLGKEAVQNLLALRFGNVLFEPLWRREWISDVQITIAEEIGVGNRMGYYETSGALRDMMQNHL 238
Cdd:PRK05722  169 DQVGEVFKEEQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDKSGALRDMVQNHL 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 239 LQLLCIVAMEPPLSVTPDAVRDEKLKVLRSLKPFTQNTLAKNVVRGQYRAGHVNGVAVPAYRQEKTADPDSNTETFVAVK 318
Cdd:PRK05722  249 LQLLALVAMEPPASLDADSIRDEKVKVLRALRPITPEDVKENTVRGQYTAGWIGGKPVPGYREEEGVNPDSTTETFVALK 328

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 319 AEIDTWRWAGVPFYLRTGKRMADQLAEIVVRFKSIPHSIFAQSTSSFQPNCLVIRLQPDDGLQLNLMAKTPGDGMRLKPV 398
Cdd:PRK05722  329 LEIDNWRWAGVPFYLRTGKRLPKKVTEIVIVFKPPPHNLFEESAEELGPNKLVIRIQPDEGISLRFNAKVPGEGMELRPV 408

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 399 ELELDFAETFKAPRMDAYERLLLDVLRGQLTLFMRSDELEAAWEWVEPVLRYWEQEGNEPLPYASGTWGPAASSSLIGRD 478
Cdd:PRK05722  409 KLDFSYSEAFGEASPEAYERLLLDVMLGDQTLFVRRDEVEAAWKWVDPILEAWEADGGPPPPYPAGTWGPEAADALLARD 488


                  ....*..
gi 1936360303 479 GLQWREE 485
Cdd:PRK05722  489 GRSWREP 495
PRK12853 PRK12853
glucose-6-phosphate dehydrogenase;
7-487 0e+00

glucose-6-phosphate dehydrogenase;


Pssm-ID: 237233 [Multi-domain]  Cd Length: 482  Bit Score: 698.19  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303   7 DLVLFGGGGDLSMRKLIPALYARDRAGDLPATAQIICVGRNERSTAEFIETVNENAKSHInEKTFSQAVWDKFCARIKYV 86
Cdd:PRK12853   10 TLVIFGATGDLARRKLLPALYRLARAGLLPEDLRIIGVGRDDWSDEQWRARVRESLRAFG-ADGFDDAVWDRLAARLSYV 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303  87 ALDASDANTYQPLNDALRdsSSVTRVFYLATPPTLFASICHNLSARGLATEQTRVVLEKPLGRDLASAKQINQEVSQVFK 166
Cdd:PRK12853   89 QGDVTDPADYARLAEALG--PGGNPVFYLAVPPSLFAPVVENLGAAGLLPEGRRVVLEKPFGHDLASARALNATLAKVFD 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 167 ESQIYRIDHYLGKEAVQNLLALRFGNVLFEPLWRREWISDVQITIAEEIGVGNRMGYYETSGALRDMMQNHLLQLLCIVA 246
Cdd:PRK12853  167 EDQIYRIDHFLGKETVQNLLALRFANALLEPLWNRNHIDHVQITVAETLGVEGRGGFYDATGALRDMVQNHLLQLLALVA 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 247 MEPPLSVTPDAVRDEKLKVLRSLKPFTQNTLakNVVRGQYRAGHVNGVAVPAYRQEKTADPDSNTETFVAVKAEIDTWRW 326
Cdd:PRK12853  247 MEPPASFDADAVRDEKAKVLRAIRPLDPDDV--HTVRGQYTAGTVGGEPVPGYREEPGVDPDSRTETFVALKLEIDNWRW 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 327 AGVPFYLRTGKRMADQLAEIVVRFKSIPHSIFaQSTSSFQPNCLVIRLQPDDGLQLNLMAKTPGDGMRLKPVELELDFAE 406
Cdd:PRK12853  325 AGVPFYLRTGKRLAERRTEIVITFKPVPHALF-RGTGVEPPNRLVIRLQPDEGISLELNVKRPGPGMRLRPVELDADYAD 403

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 407 TfkAPRMDAYERLLLDVLRGQLTLFMRSDELEAAWEWVEPVLRYWEQEGNEPLPYASGTWGPAASSSLIGRDGLQWREEA 486
Cdd:PRK12853  404 D--ERPLEAYERLLLDVLRGDPTLFVRADEVEAAWRIVDPVLDAWAADPVPPHEYPAGSWGPAAADALLARDGRGWREPA 481


                  .
gi 1936360303 487 L 487
Cdd:PRK12853  482 A 482
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 5-484 0e+00

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 625.88  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303   5 DFDLVLFGGGGDLSMRKLIPALYARDRAGDLPATAQIICVGRNERSTAEFIETVNEnAKSHINEKTFSQAvWDKFCARIK 84
Cdd:TIGR00871   2 PCILVIFGASGDLARKKLFPALYRLFRNGLLPPDFRIVGVARRDWSVEEFRKVVRE-AIIKFETDEIDEQ-WDEFAQRLS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303  85 YVALDASDANTYQPLNDALRDS-----SSVTRVFYLATPPTLFASICHNLSARGLATE--QTRVVLEKPLGRDLASAKQI 157
Cdd:TIGR00871  80 YVSGDVDDDESYDSLAELLEQLdktygTEGNRLFYLATPPSLFGTIIKQLKKHGLNEQgkWSRVVVEKPFGHDLASAQEL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 158 NQEVSQVFKESQIYRIDHYLGKEAVQNLLALRFGNVLFEPLWRREWISDVQITIAEEIGVGNRMGYYETSGALRDMMQNH 237
Cdd:TIGR00871 160 NKALRAVFKEDQIYRIDHYLGKETVQNLLVLRFANQIFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGALRDMVQNH 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 238 LLQLLCIVAMEPPLSVTPDAVRDEKLKVLRSLKPFTqnTLAKNVVRGQYRAGHVNGVAVPAYRQEKTADPDSNTETFVAV 317
Cdd:TIGR00871 240 LLQLLALVAMEPPVSFDADSIRDEKVKVLKALRPID--PDDNNTVRGQYGAGEIGGVSVPGYLEEEGVDKDSNTETFAAL 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 318 KAEIDTWRWAGVPFYLRTGKRMADQLAEIVVRFKSIPHSIFAQSTSSFQP-NCLVIRLQPDDGLQLNLMAKTPGDGMRLK 396
Cdd:TIGR00871 318 KLEIDNWRWAGVPFYLRTGKRLPEKVTEIRIQFRDVPSLLFKANERDANPrNALVIRIQPDEGVYLKFNAKKPGLNFETR 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 397 PVELELDFAETFKAPRMDAYERLLLDVLRGQLTLFMRSDELEAAWEWVEPVLRYWEQEGNE-PLPYASGTWGPAASSSLI 475
Cdd:TIGR00871 398 PVKLDFSYASRFGELLPEAYERLLLDALLGDHTLFARDDEVEEAWRIVTPILEAWAANKGPsPPNYPAGSWGPKEADELI 477


                  ....*....
gi 1936360303 476 GRDGLQWRE 484
Cdd:TIGR00871 478 RKDGRSWRK 486
PRK12854 PRK12854
glucose-6-phosphate 1-dehydrogenase; Provisional
 6-486 0e+00

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 237234 [Multi-domain]  Cd Length: 484  Bit Score: 536.15  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303   6 FDLVLFGGGGDLSMRKLIPALYARDRAGDLPATAQIICVGRNERSTAEFIETVNEnAKSHINEKTFSQAVWDKFCARIKY 85
Cdd:PRK12854   12 TVFVLFGATGDLAKRKLLPGLFHLARAGLLPPDWRIVGTGRGDVSAEAFREHARD-ALDEFGARKLDDGEWARFAKRLRY 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303  86 VALDASDANTyQPLNDALRDSSS-----VTRVFYLATPPTLFASICHNLSARGLAtEQTRVVLEKPLGRDLASAKQINQE 160
Cdd:PRK12854   91 VPGGFLSAGP-GALAAAVAAARAelggdARLVHYLAVPPSAFLDVTRALGEAGLA-EGSRVVMEKPFGTDLASAEALNAA 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 161 VSQVFKESQIYRIDHYLGKEAVQNLLALRFGNVLFEPLWRREWISDVQITIAEEIGVGNRMGYYETSGALRDMMQNHLLQ 240
Cdd:PRK12854  169 VHEVFDESQIFRIDHFLGKEAAQNILAFRFANGLFEPIWNREFIDHVQIDVPETLGVDTRAAFYDATGAYRDMVVTHLFQ 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 241 LLCIVAMEPPLSVTPDAVRDEKLKVLRSLKPFTqntlAKNVVRGQYRaghvngvavpAYRQEKTADPDSNTETFVAVKAE 320
Cdd:PRK12854  249 VLAFVAMEPPTALEPDAISEEKNKVFRSMRPLD----PAEVVRGQYS----------GYRDEPGVAPDSTTETFVALKVW 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 321 IDTWRWAGVPFYLRTGKRMADQLAEIVVRFKSIPHSIF-AQSTSSFQPNCLVIRLQPDDGLQLNLMAKTPGDGMRLKPVE 399
Cdd:PRK12854  315 IDNWRWAGVPFYLRTGKRMAEGQRIISIAFREPPYSMFpAGSVGAQGPDHLTFDLADNSKVSLSFYGKRPGPGMRLDKLS 394

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 400 LELDFAET-FKAPRMDAYERLLLDVLRGQLTLFMRSDELEAAWEWVEPVLRyweqEGNEPLPYASGTWGPAASSSLIGRD 478
Cdd:PRK12854  395 LQFSLKDTgPKGDVLEAYERLILDALRGDHTLFTTADGIESLWEVSQPLLE----DPPPVKPYAPGSWGPNAIHQLAAPD 470

                         490
                  ....*....|....
gi 1936360303 479 GL------QWREEA 486
Cdd:PRK12854  471 AWrlpferEWRELG 484
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
186-483 0e+00

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 525.08  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 186 LALRFGNVLFEPLWRREWISDVQITIAEEIGVGNRMGYYETSGALRDMMQNHLLQLLCIVAMEPPLSVTPDAVRDEKLKV 265
Cdd:pfam02781   1 LVLRFANAIFEPLWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAMEPPVSFDAEDIRDEKVKV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 266 LRSLKPFTQNTLAKNVVRGQYRAGHVNGVAVPAYRQEKTADPDSNTETFVAVKAEIDTWRWAGVPFYLRTGKRMADQLAE 345
Cdd:pfam02781  81 LRSLRPITPEDVEDNVVRGQYGAGWIGGEPVPGYREEEGVPPDSRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERVTE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 346 IVVRFKSIPHSIFAQStSSFQPNCLVIRLQPDDGLQLNLMAKTPGDGMRLKPVELELDFAETFKAPRMDAYERLLLDVLR 425
Cdd:pfam02781 161 IRIQFKDVPHNLFRDP-GTLPPNELVIRIQPDEGIYLKFNAKVPGLGMRLRPVELDFSYSDRFGERIPEAYERLLLDVMR 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1936360303 426 GQLTLFMRSDELEAAWEWVEPVLRYWEQEgnEPLPYASGTWGPAASSSLIGRDGLQWR 483
Cdd:pfam02781 240 GDQTLFVRSDEVEAAWRIVDPILEAWDEE--KPPPYPAGSWGPKAADELLARDGRKWR 295
PTZ00309 PTZ00309
glucose-6-phosphate 1-dehydrogenase; Provisional
 2-480 2.97e-140

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 414.15  E-value: 2.97e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303   2 ALTdfdLVLFGGGGDLSMRKLIPALYARDRAGDLPATAQIICVGRNERSTAEfiETVNEN-AKSHINEKTFSQAVwDKFC 80
Cdd:PTZ00309   54 ALT---IIVLGASGDLAKKKTFPALFQLYCEGLLPSEVNIVGYARSKMSDVE--RWKKETlARFFKRLDDRECHL-EQFL 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303  81 ARIKYVALDASDANTYQPLNDALRD--------SSSVTRVFYLATPPTLFASICHNLSaRGLATEQ--TRVVLEKPLGRD 150
Cdd:PTZ00309  128 KHISYISGSYDEDEDFKRLNKLIERmeeafqgpEKGGNRLFYLALPPSVFASVCEGIH-RGCMSKNgwVRVIVEKPFGRD 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 151 LASAKQINQEVSQVFKESQIYRIDHYLGKEAVQNLLALRFGNVLFEPLWRREWISDVQITIAEEIGVGNRMGYYETSGAL 230
Cdd:PTZ00309  207 LESSEELSNQLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANRVFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSYGII 286

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 231 RDMMQNHLLQLLCIVAMEPPLSVTPDAVRDEKLKVLRSLKPFTQntlaKNVVRGQYRAGhvNGVAVPAYRQEKTADPDSN 310
Cdd:PTZ00309  287 RDVMQNHLLQILALLAMEKPVSLSAEDIRDEKVKVLKCIEPIKM----EECVLGQYTAS--ADGSIPGYLEDEGVPKDST 360

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 311 TETFVAVKAEIDTWRWAGVPFYLRTGKRMADQLAEIVVRFKSIPHSIFaqSTSSFQPNCLVIRLQPDDGLQLNLMAKTPG 390
Cdd:PTZ00309  361 TPTFAAAVLHINNDRWEGVPFILEAGKALEERYVEIRIQFKGVDEFRP--SGDDTQRNELVIRAQPSEAMYLKITAKVPG 438

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 391 DGMRLKPVELELDFAETFKAPRMDAYERLLLDVLRGQLTLFMRSDELEAAWEWVEPVLRYWEQEGNEPLPYASGTWGPAA 470
Cdd:PTZ00309  439 LSNDLHQTELDLTYKTRYNVRLPDAYERLILDALLGDSTNFVRKDELDVAWRIFTPLLHQIDRGEVKPEPYPFGSRGPKE 518

                         490
                  ....*....|
gi 1936360303 471 SSSLIGRDGL 480
Cdd:PTZ00309  519 ADELIKKNGF 528
PLN02539 PLN02539
glucose-6-phosphate 1-dehydrogenase
 8-479 2.94e-129

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 178154 [Multi-domain]  Cd Length: 491  Bit Score: 384.08  E-value: 2.94e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303   8 LVLFGGGGDLSMRKLIPALYARDRAGDL-PATAQIICVGRNERSTAEFIETVNENAKshiNEKTFSQAVWDKFCARIKYV 86
Cdd:PLN02539   20 IIVLGASGDLAKKKTFPALFNLYRQGFLpPDEVHIFGYARSKITDEELRDRIRGYLK---DEKNAPAEAVSKFLQLIKYV 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303  87 ALDASDANTYQPLNDALR--------DSSSVTRVFYLATPPTLFASICHNLSARGLATEQ--TRVVLEKPLGRDLASAKQ 156
Cdd:PLN02539   97 SGAYDSEEGFRRLDKEISeheisknsAEGSSRRLFYLALPPSVYPPVCKMIKKCCMNKSGlwTRIVVEKPFGKDLESAEE 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 157 INQEVSQVFKESQIYRIDHYLGKEAVQNLLALRFGNVLFEPLWRREWISDVQITIAEEIGVGNRMGYYETSGALRDMMQN 236
Cdd:PLN02539  177 LSSQIGELFDESQLYRIDHYLGKELVQNLLVLRFANRFFLPLWNRDNIANVQIVFREDFGTEGRGGYFDEYGIIRDIIQN 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 237 HLLQLLCIVAMEPPLSVTPDAVRDEKLKVLRSLKPFTQntlaKNVVRGQYraghvngvavPAYRQEKTADPDSNTETFVA 316
Cdd:PLN02539  257 HLLQVLCLVAMEKPVSLKPEHIRDEKVKVLQSVEPIKD----EEVVLGQY----------EGYRDDPTVPDDSNTPTFAS 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 317 VKAEIDTWRWAGVPFYLRTGKRMADQLAEIVVRFKSIPHSIFA---QSTSSFqpnclVIRLQPDDGLQLNLMAKTPGDGM 393
Cdd:PLN02539  323 VVLRINNERWEGVPFILKAGKALDSRKAEIRVQFKDVPGDIFKcqkQGRNEF-----VIRLQPSEAMYMKLTVKQPGLEM 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 394 RLKPVELELDFAETFK-APRMDAYERLLLDVLRGQLTLFMRSDELEAAWEWVEPVLRYWEQEGNEPLPYASGTWGPAASS 472
Cdd:PLN02539  398 STVQSELDLSYGQRYQdVVIPEAYERLILDTIRGDQQHFVRRDELKAAWEIFTPLLHRIDAGKVKPIPYKQGSRGPAEAD 477


                  ....*..
gi 1936360303 473 SLIGRDG 479
Cdd:PLN02539  478 ELLEKAG 484
PLN02333 PLN02333
glucose-6-phosphate 1-dehydrogenase
 8-482 2.36e-123

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215191 [Multi-domain]  Cd Length: 604  Bit Score: 372.77  E-value: 2.36e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303   8 LVLFGGGGDLSMRKLIPALYARDRAGDLPATAQIICVGRNERSTAEFIETVNENAKSHINEKTFSQAVWDKFCARIKYVA 87
Cdd:PLN02333  120 ITVVGASGDLAKKKIFPALFALYYEGCLPEHFTIFGYARSKMTDAELRNMVSKTLTCRIDKRENCGEKMEEFLKRCFYHS 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303  88 LDASDANTYQPLNDALRDSSS---VTRVFYLATPPTLF--ASICHNLSARGlATEQTRVVLEKPLGRDLASAKQINQEVS 162
Cdd:PLN02333  200 GQYDSQEHFAELDKKLKEHEGgrvSNRLFYLSIPPNIFvdAVKCASSSASS-VNGWTRVIVEKPFGRDSESSAALTKSLK 278

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 163 QVFKESQIYRIDHYLGKEAVQNLLALRFGNVLFEPLWRREWISDVQITIAEEIGVGNRMGYYETSGALRDMMQNHLLQLL 242
Cdd:PLN02333  279 QYLEEDQIFRIDHYLGKELVENLSVLRFSNLIFEPLWSRQYIRNVQFIFSEDFGTEGRGGYFDNYGIIRDIMQNHLLQIL 358

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 243 CIVAMEPPLSVTPDAVRDEKLKVLRSLKPFTqntlAKNVVRGQYRAGHVNGVAVPAYRQEKTADPDSNTETFVAVKAEID 322
Cdd:PLN02333  359 ALFAMETPVSLDAEDIRNEKVKVLRSMRPIQ----LEDVVIGQYKSHTKGGVTYPAYTDDKTVPKGSLTPTFAAAALFID 434

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 323 TWRWAGVPFYLRTGKRMADQLAEIVVRFKSIPHSIFAQSTSS---FQPNCLVIRLQPDDGLQLNLMAKTPGDGMRLKPVE 399
Cdd:PLN02333  435 NARWDGVPFLMKAGKALHTKSAEIRVQFRHVPGNLYNRNFGTdldQATNELVIRVQPDEAIYLKINNKVPGLGMRLDRSN 514

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 400 LELDFAETFKAPRMDAYERLLLDVLRGQLTLFMRSDELEAAWEWVEPVLRYWEQEGNEPLPYASGTWGPAASSSLIGRDG 479
Cdd:PLN02333  515 LNLLYAARYSKEIPDAYERLLLDAIEGERRLFIRSDELDAAWALFTPLLKELEEKKIIPEYYPYGSRGPVGAHYLAARYK 594


                  ...
gi 1936360303 480 LQW 482
Cdd:PLN02333  595 VRW 597
PLN02640 PLN02640
glucose-6-phosphate 1-dehydrogenase
 4-482 7.05e-119

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215344 [Multi-domain]  Cd Length: 573  Bit Score: 360.48  E-value: 7.05e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303   4 TDFDLVLFGGGGDLSMRKLIPALYARDRAGDLPATAQIICVGRNERSTAEFIETVNENAKSHINEKTFSQAVWDKFCARI 83
Cdd:PLN02640   87 STLSITVVGASGDLAKKKIFPALFALFYEDWLPENFTVFGYARTKLTDEELRDMISSTLTCRIDQRENCGDKMDQFLKRC 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303  84 KYVALDASDANTYQPLNDALRDSSS---VTRVFYLATPPTLFASICHNLSARGLATEQ-TRVVLEKPLGRDLASAKQINQ 159
Cdd:PLN02640  167 FYHSGQYDSEEDFAELNKKLKEKEAgklSNRLFYLSIPPNIFVDVVRCASLRASSENGwTRVIVEKPFGRDSESSGELTR 246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 160 EVSQVFKESQIYRIDHYLGKEAVQNLLALRFGNVLFEPLWRREWISDVQITIAEEIGVGNRMGYYETSGALRDMMQNHLL 239
Cdd:PLN02640  247 CLKQYLTEEQIFRIDHYLGKELVENLSVLRFSNLVFEPLWSRNYIRNVQLIFSEDFGTEGRGGYFDNYGIIRDIMQNHLL 326

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 240 QLLCIVAMEPPLSVTPDAVRDEKLKVLRSLKPFTqntlAKNVVRGQYRAGHVNGVAVPAYRQEKTADPDSNTETFVAVKA 319
Cdd:PLN02640  327 QILALFAMETPVSLDAEDIRNEKVKVLRSMKPLQ----LEDVIVGQYKGHSKGGKSYPAYTDDPTVPKHSLTPTFAAAAL 402

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 320 EIDTWRWAGVPFYLRTGKRMADQLAEIVVRFKSIPHSIFAQSTSS---FQPNCLVIRLQPDDGLQLNLMAKTPGDGMRLK 396
Cdd:PLN02640  403 FINNARWDGVPFLMKAGKALHTRRAEIRVQFRHVPGNLYKRNFGTdldKATNELVLRVQPDEAIYLKINNKVPGLGMRLD 482

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303 397 PVELELDFAETFKAPRMDAYERLLLDVLRGQLTLFMRSDELEAAWEWVEPVLRYWEQEGNEPLPYASGTWGPAASSSLIG 476
Cdd:PLN02640  483 RSDLNLLYRARYPREIPDAYERLLLDAIEGERRLFIRSDELDAAWALFTPLLKELEEKKIIPELYPYGSRGPVGAHYLAA 562


                  ....*.
gi 1936360303 477 RDGLQW 482
Cdd:PLN02640  563 KYNVRW 568
G6PD_N pfam00479
Glucose-6-phosphate dehydrogenase, NAD binding domain;
9-184 1.14e-84

Glucose-6-phosphate dehydrogenase, NAD binding domain;


Pssm-ID: 459827 [Multi-domain]  Cd Length: 178  Bit Score: 258.51  E-value: 1.14e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303   9 VLFGGGGDLSMRKLIPALYARDRAGDLPATAQIICVGRNERSTAEFIETVNENAKSHineKTFSQAVWDKFCARIKYVAL 88
Cdd:pfam00479   1 VIFGATGDLAKRKLFPALYNLYRDGLLPEGFRIIGVARRDLSDEEFRERVREALKEF---KELDEEKWDRFLERLHYVSG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1936360303  89 DASDANTYQPLNDALRDSSSVT---RVFYLATPPTLFASICHNLSARGLATEQ--TRVVLEKPLGRDLASAKQINQEVSQ 163
Cdd:pfam00479  78 DFDDPESYEKLKERLEEHEDETrgnRLFYLAVPPSLFGPIAENLGRAGLSEEGgwRRVVIEKPFGHDLESARELNDQLAK 157

                         170       180
                  ....*....|....*....|.
gi 1936360303 164 VFKESQIYRIDHYLGKEAVQN 184
Cdd:pfam00479 158 VFKEEQIYRIDHYLGKETVQN 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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