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Conserved domains on  [gi|1928617803|ref|WP_194102478|]
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UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [Mucilaginibacter sp. JRF]

Protein Classification

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase( domain architecture ID 11433680)

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein

CATH:  3.90.190.20|3.40.1190.10|3.40.1390.10
EC:  6.3.2.10
Gene Ontology:  GO:0005524|GO:0009252|GO:0047480|GO:0071555
PubMed:  16934839
SCOP:  4000234

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
MurF COG0770
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 16-435 6.82e-161

UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


:

Pssm-ID: 440533 [Multi-domain]  Cd Length: 451  Bit Score: 461.11  E-value: 6.82e-161
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803  16 ISTDTRRIAPGSLFFALKGDKFDANTFAAQAVEAGAAYAVIDDAkYRVSEQYILVDDVLETLQNLARYHRKQLNIPVVGL 95
Cdd:COG0770    27 VSTDSRKIKPGDLFVALKGERFDGHDFVAQALAKGAAAALVSRP-LPADLPLIVVDDTLKALQQLAAAHRARFNIPVIAI 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803  96 tgtngktttkELINAVLSQHFNTLATQGNLNNHIGVPLTILSITAEHEAAVIEMGANHQKEIEMLCTISQPTHGLITNVG 175
Cdd:COG0770   106 tgsngktttkEMLAAVLSTKGKVLATPGNFNNEIGVPLTLLRLPEDHEFAVLEMGMNHPGEIAYLARIARPDIAVITNIG 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 176 KAHLEGFGGVEGVKIAKGELYDHLATHGAnVFINADDATLQQMAAkRTFKKQLFYGTqGDDSLITGKLIENSP-HLVLEW 254
Cdd:COG0770   186 PAHLEGFGSLEGIARAKGEIFEGLPPGGV-AVLNADDPLLAALAE-RAKARVLTFGL-SEDADVRAEDIELDEdGTRFTL 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 255 HEKGssKTHQVKSNLTGVYNLDNILAAICVGTYLGLTPTEINKGLEGYQPKNNRSQIVKTA-TNTLICDYYNANPSSMMV 333
Cdd:COG0770   263 HTPG--GELEVTLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKGRLEVIEGAgGVTLIDDSYNANPDSMKA 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 334 AIENVDKITAE-KKVLILGDMFELGDDAPAEHLAVIEKAEAAGVNERIFIGKEFSA---ARVSHAGQYFETAEDAIEALQ 409
Cdd:COG0770   341 ALDVLAQLPGGgRRIAVLGDMLELGEESEELHREVGELAAELGIDRLFTVGELARAiaeAAGGERAEHFEDKEELLAALK 420

                         410       420
                  ....*....|....*....|....*.
gi 1928617803 410 NDPITNATILIKGSRGMALERLVALF 435
Cdd:COG0770   421 ALLRPGDVVLVKGSRGMGLERVVEAL 446
 
Name Accession Description Interval E-value
MurF COG0770
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 16-435 6.82e-161

UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440533 [Multi-domain]  Cd Length: 451  Bit Score: 461.11  E-value: 6.82e-161
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803  16 ISTDTRRIAPGSLFFALKGDKFDANTFAAQAVEAGAAYAVIDDAkYRVSEQYILVDDVLETLQNLARYHRKQLNIPVVGL 95
Cdd:COG0770    27 VSTDSRKIKPGDLFVALKGERFDGHDFVAQALAKGAAAALVSRP-LPADLPLIVVDDTLKALQQLAAAHRARFNIPVIAI 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803  96 tgtngktttkELINAVLSQHFNTLATQGNLNNHIGVPLTILSITAEHEAAVIEMGANHQKEIEMLCTISQPTHGLITNVG 175
Cdd:COG0770   106 tgsngktttkEMLAAVLSTKGKVLATPGNFNNEIGVPLTLLRLPEDHEFAVLEMGMNHPGEIAYLARIARPDIAVITNIG 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 176 KAHLEGFGGVEGVKIAKGELYDHLATHGAnVFINADDATLQQMAAkRTFKKQLFYGTqGDDSLITGKLIENSP-HLVLEW 254
Cdd:COG0770   186 PAHLEGFGSLEGIARAKGEIFEGLPPGGV-AVLNADDPLLAALAE-RAKARVLTFGL-SEDADVRAEDIELDEdGTRFTL 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 255 HEKGssKTHQVKSNLTGVYNLDNILAAICVGTYLGLTPTEINKGLEGYQPKNNRSQIVKTA-TNTLICDYYNANPSSMMV 333
Cdd:COG0770   263 HTPG--GELEVTLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKGRLEVIEGAgGVTLIDDSYNANPDSMKA 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 334 AIENVDKITAE-KKVLILGDMFELGDDAPAEHLAVIEKAEAAGVNERIFIGKEFSA---ARVSHAGQYFETAEDAIEALQ 409
Cdd:COG0770   341 ALDVLAQLPGGgRRIAVLGDMLELGEESEELHREVGELAAELGIDRLFTVGELARAiaeAAGGERAEHFEDKEELLAALK 420

                         410       420
                  ....*....|....*....|....*.
gi 1928617803 410 NDPITNATILIKGSRGMALERLVALF 435
Cdd:COG0770   421 ALLRPGDVVLVKGSRGMGLERVVEAL 446
murF TIGR01143
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ...
 18-435 7.99e-113

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273468 [Multi-domain]  Cd Length: 417  Bit Score: 337.70  E-value: 7.99e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803  18 TDTRRIAPGSLFFALKGDKFDANTFAAQAVEAGAAYAVID-DAKYRVSEQYILVDDVLETLQNLARYHRKQLNIPVVGLT 96
Cdd:TIGR01143   1 TDSRAIKPGDLFIALKGERFDGHDFVEQALAAGAVAVVVDrEVGPDNGLPQILVDDTLEALQALARAKRAKFSGKVIGIT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803  97 GTNGKTTTKELINAVLSQHFNTLATQGNLNNHIGVPLTILSITAEHEAAVIEMGANHQKEIEMLCTISQPTHGLITNVGK 176
Cdd:TIGR01143  81 GSSGKTTTKEMLAAILSHKYKVFATPGNFNNEIGLPLTLLRAPGDHDYAVLEMGASHPGEIAYLAEIAKPDIAVITNIGP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 177 AHLEGFGGVEGVKIAKGELYDHLATHGAnVFINADDATLQQMAAKRTFKKQLFYGTQGDDslITGKLIE----NSPHLVL 252
Cdd:TIGR01143 161 AHLEGFGSLEGIAEAKGEILQGLKENGI-AVINADDPAFADLAKRLPNRNILSFGFEGGD--FVAKDISysalGSTSFTL 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 253 EWHEkgssKTHQVKSNLTGVYNLDNILAAICVGTYLGLTPTEINKGLEGYQPKNNRSQIVKTATNTLICDYYNANPSSMM 332
Cdd:TIGR01143 238 VAPG----GEFEVSLPLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKLVKGRFEVQTKNGLTLIDDTYNANPDSMR 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 333 VAIENVdKITAEKKVLILGDMFELGDDAPAEHLAVIEKAEAAGVNERIFIGKEFSAARVS--HAGQYFETAEDAIEALQN 410
Cdd:TIGR01143 314 AALDAL-ARFPGKKILVLGDMAELGEYSEELHAEVGRYANSLGIDLVFLVGEEAAVIYDSfgKQGKHFADKDELLAFLKT 392

                         410       420
                  ....*....|....*....|....*
gi 1928617803 411 DPITNATILIKGSRGMALERLVALF 435
Cdd:TIGR01143 393 LVRKGDVVLVKGSRSVKLEKVVEAL 417
PRK11929 PRK11929
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ...
 16-432 4.92e-102

bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;


Pssm-ID: 237025 [Multi-domain]  Cd Length: 958  Bit Score: 324.73  E-value: 4.92e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803  16 ISTDTRRIAPGSLFFALKGDKFDANTFAAQAVEAGAAYAVIDDAKYRVSEQYILVDDVLETLQNLARYHRKQLNIPVVGL 95
Cdd:PRK11929  529 VSTDSRSVGRGELFVALRGENFDGHDYLPQAFAAGACAAVVERQVADVDLPQIVVDDTRAALGRLATAWRARFSLPVVAI 608

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803  96 TGTNGKTTTKELINAVLSQ---HFNTLATQGNLNNHIGVPLTILSITAEHEAAVIEMGANHQKEIEMLCTISQPTHGLIT 172
Cdd:PRK11929  609 TGSNGKTTTKEMIAAILAAwqgEDRVLATEGNFNNEIGVPLTLLRLRAQHRAAVFELGMNHPGEIAYLAAIAAPTVALVT 688

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 173 NVGKAHLEGFGGVEGVKIAKGELYDHLATHGANVFiNADDATLQ----QMAAKRTFKKQLFYGTQGDDSLITGKLIENSP 248
Cdd:PRK11929  689 NAQREHQEFMHSVEAVARAKGEIIAALPEDGVAVV-NGDDPYTAiwakLAGARRVLRFGLQPGADVYAEKIAKDISVGEA 767

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 249 H-LVLEWHEKGSSKthQVKSNLTGVYNLDNILAAICVGTYLGLTPTEINKGLEGYQPKNNRSQIVKTATNT-LICDYYNA 326
Cdd:PRK11929  768 GgTRCQVVTPAGSA--EVYLPLIGEHNLRNALAAIACALAAGASLKQIRAGLERFQPVAGRMQRRRLSCGTrIIDDTYNA 845

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 327 NPSSMMVAIENVDKITAEKKVLILGDMFELGDDAPAEHLAVIEKAEAAGVnERIFIGKEFSAARV----SHAGQYFETAE 402
Cdd:PRK11929  846 NPDSMRAAIDVLAELPNGPRALVLGDMLELGDNGPAMHREVGKYARQLGI-DALITLGEAARDAAaafgAGARGVCASVD 924

                         410       420       430
                  ....*....|....*....|....*....|
gi 1928617803 403 DAIEALQNDPITNATILIKGSRGMALERLV 432
Cdd:PRK11929  925 EIIAALRGALPEGDSVLIKGSRFMRLERVV 954
Mur_ligase_M pfam08245
Mur ligase middle domain;
102-285 5.64e-28

Mur ligase middle domain;


Pssm-ID: 462409 [Multi-domain]  Cd Length: 199  Bit Score: 109.70  E-value: 5.64e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 102 TTTKELINAVLSQHFNTLATQG--------NLNNHIGVPLTILSIT-AEHEAAVIEMGANHQKEiEMLCTISQPTHGLIT 172
Cdd:pfam08245   8 TTTTELIAAILSLAGGVIGTIGtyigksgnTTNNAIGLPLTLAEMVeAGAEYAVLEVSSHGLGE-GRLSGLLKPDIAVFT 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 173 NVGKAHLEGFGGVEGVKIAKGELYDHLATHGAnVFINADD---ATLQQMAAKRTFKKqLFYGTQGDDSLITGKLIENSPH 249
Cdd:pfam08245  87 NISPDHLDFHGTMENYAKAKAELFEGLPEDGI-AVINADDpygAFLIAKLKKAGVRV-ITYGIEGEADLRAANIELSSDG 164

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1928617803 250 LVLEWHEKgSSKTHQVKSNLTGVYNLDNILAAICVG 285
Cdd:pfam08245 165 TSFDLFTV-PGGELEIEIPLLGRHNVYNALAAIAAA 199
 
Name Accession Description Interval E-value
MurF COG0770
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 16-435 6.82e-161

UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440533 [Multi-domain]  Cd Length: 451  Bit Score: 461.11  E-value: 6.82e-161
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803  16 ISTDTRRIAPGSLFFALKGDKFDANTFAAQAVEAGAAYAVIDDAkYRVSEQYILVDDVLETLQNLARYHRKQLNIPVVGL 95
Cdd:COG0770    27 VSTDSRKIKPGDLFVALKGERFDGHDFVAQALAKGAAAALVSRP-LPADLPLIVVDDTLKALQQLAAAHRARFNIPVIAI 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803  96 tgtngktttkELINAVLSQHFNTLATQGNLNNHIGVPLTILSITAEHEAAVIEMGANHQKEIEMLCTISQPTHGLITNVG 175
Cdd:COG0770   106 tgsngktttkEMLAAVLSTKGKVLATPGNFNNEIGVPLTLLRLPEDHEFAVLEMGMNHPGEIAYLARIARPDIAVITNIG 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 176 KAHLEGFGGVEGVKIAKGELYDHLATHGAnVFINADDATLQQMAAkRTFKKQLFYGTqGDDSLITGKLIENSP-HLVLEW 254
Cdd:COG0770   186 PAHLEGFGSLEGIARAKGEIFEGLPPGGV-AVLNADDPLLAALAE-RAKARVLTFGL-SEDADVRAEDIELDEdGTRFTL 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 255 HEKGssKTHQVKSNLTGVYNLDNILAAICVGTYLGLTPTEINKGLEGYQPKNNRSQIVKTA-TNTLICDYYNANPSSMMV 333
Cdd:COG0770   263 HTPG--GELEVTLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKGRLEVIEGAgGVTLIDDSYNANPDSMKA 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 334 AIENVDKITAE-KKVLILGDMFELGDDAPAEHLAVIEKAEAAGVNERIFIGKEFSA---ARVSHAGQYFETAEDAIEALQ 409
Cdd:COG0770   341 ALDVLAQLPGGgRRIAVLGDMLELGEESEELHREVGELAAELGIDRLFTVGELARAiaeAAGGERAEHFEDKEELLAALK 420

                         410       420
                  ....*....|....*....|....*.
gi 1928617803 410 NDPITNATILIKGSRGMALERLVALF 435
Cdd:COG0770   421 ALLRPGDVVLVKGSRGMGLERVVEAL 446
murF TIGR01143
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ...
 18-435 7.99e-113

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273468 [Multi-domain]  Cd Length: 417  Bit Score: 337.70  E-value: 7.99e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803  18 TDTRRIAPGSLFFALKGDKFDANTFAAQAVEAGAAYAVID-DAKYRVSEQYILVDDVLETLQNLARYHRKQLNIPVVGLT 96
Cdd:TIGR01143   1 TDSRAIKPGDLFIALKGERFDGHDFVEQALAAGAVAVVVDrEVGPDNGLPQILVDDTLEALQALARAKRAKFSGKVIGIT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803  97 GTNGKTTTKELINAVLSQHFNTLATQGNLNNHIGVPLTILSITAEHEAAVIEMGANHQKEIEMLCTISQPTHGLITNVGK 176
Cdd:TIGR01143  81 GSSGKTTTKEMLAAILSHKYKVFATPGNFNNEIGLPLTLLRAPGDHDYAVLEMGASHPGEIAYLAEIAKPDIAVITNIGP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 177 AHLEGFGGVEGVKIAKGELYDHLATHGAnVFINADDATLQQMAAKRTFKKQLFYGTQGDDslITGKLIE----NSPHLVL 252
Cdd:TIGR01143 161 AHLEGFGSLEGIAEAKGEILQGLKENGI-AVINADDPAFADLAKRLPNRNILSFGFEGGD--FVAKDISysalGSTSFTL 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 253 EWHEkgssKTHQVKSNLTGVYNLDNILAAICVGTYLGLTPTEINKGLEGYQPKNNRSQIVKTATNTLICDYYNANPSSMM 332
Cdd:TIGR01143 238 VAPG----GEFEVSLPLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKLVKGRFEVQTKNGLTLIDDTYNANPDSMR 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 333 VAIENVdKITAEKKVLILGDMFELGDDAPAEHLAVIEKAEAAGVNERIFIGKEFSAARVS--HAGQYFETAEDAIEALQN 410
Cdd:TIGR01143 314 AALDAL-ARFPGKKILVLGDMAELGEYSEELHAEVGRYANSLGIDLVFLVGEEAAVIYDSfgKQGKHFADKDELLAFLKT 392

                         410       420
                  ....*....|....*....|....*
gi 1928617803 411 DPITNATILIKGSRGMALERLVALF 435
Cdd:TIGR01143 393 LVRKGDVVLVKGSRSVKLEKVVEAL 417
PRK11929 PRK11929
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ...
 16-432 4.92e-102

bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;


Pssm-ID: 237025 [Multi-domain]  Cd Length: 958  Bit Score: 324.73  E-value: 4.92e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803  16 ISTDTRRIAPGSLFFALKGDKFDANTFAAQAVEAGAAYAVIDDAKYRVSEQYILVDDVLETLQNLARYHRKQLNIPVVGL 95
Cdd:PRK11929  529 VSTDSRSVGRGELFVALRGENFDGHDYLPQAFAAGACAAVVERQVADVDLPQIVVDDTRAALGRLATAWRARFSLPVVAI 608

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803  96 TGTNGKTTTKELINAVLSQ---HFNTLATQGNLNNHIGVPLTILSITAEHEAAVIEMGANHQKEIEMLCTISQPTHGLIT 172
Cdd:PRK11929  609 TGSNGKTTTKEMIAAILAAwqgEDRVLATEGNFNNEIGVPLTLLRLRAQHRAAVFELGMNHPGEIAYLAAIAAPTVALVT 688

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 173 NVGKAHLEGFGGVEGVKIAKGELYDHLATHGANVFiNADDATLQ----QMAAKRTFKKQLFYGTQGDDSLITGKLIENSP 248
Cdd:PRK11929  689 NAQREHQEFMHSVEAVARAKGEIIAALPEDGVAVV-NGDDPYTAiwakLAGARRVLRFGLQPGADVYAEKIAKDISVGEA 767

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 249 H-LVLEWHEKGSSKthQVKSNLTGVYNLDNILAAICVGTYLGLTPTEINKGLEGYQPKNNRSQIVKTATNT-LICDYYNA 326
Cdd:PRK11929  768 GgTRCQVVTPAGSA--EVYLPLIGEHNLRNALAAIACALAAGASLKQIRAGLERFQPVAGRMQRRRLSCGTrIIDDTYNA 845

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 327 NPSSMMVAIENVDKITAEKKVLILGDMFELGDDAPAEHLAVIEKAEAAGVnERIFIGKEFSAARV----SHAGQYFETAE 402
Cdd:PRK11929  846 NPDSMRAAIDVLAELPNGPRALVLGDMLELGDNGPAMHREVGKYARQLGI-DALITLGEAARDAAaafgAGARGVCASVD 924

                         410       420       430
                  ....*....|....*....|....*....|
gi 1928617803 403 DAIEALQNDPITNATILIKGSRGMALERLV 432
Cdd:PRK11929  925 EIIAALRGALPEGDSVLIKGSRFMRLERVV 954
murF PRK10773
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed
 16-432 4.44e-69

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed


Pssm-ID: 182718 [Multi-domain]  Cd Length: 453  Bit Score: 226.07  E-value: 4.44e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803  16 ISTDTRRIAPGSLFFALKGDKFDANTFAAQAVEAGAAyAVIDDAKYRVSEQYILVDDVLETLQNLARYHRKQLNIPVVGL 95
Cdd:PRK10773   27 VTTDTRKVTPGCLFVALKGERFDAHDFADDAKAAGAG-ALLVSRPLDIDLPQLVVKDTRLAFGQLAAWVRQQVPARVVAL 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803  96 TGTNGKTTTKELINAVLSQHFNTLATQGNLNNHIGVPLTILSITAEHEAAVIEMGANHQKEIEMLCTISQPTHGLITNVG 175
Cdd:PRK10773  106 TGSSGKTSVKEMTAAILRQCGNTLYTAGNLNNDIGVPLTLLRLTPEHDYAVIELGANHQGEIAYTVSLTRPEAALVNNLA 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 176 KAHLEGFGGVEGVKIAKGELYDHLATHGAnVFINADD---ATLQQMAAKRTFKKqlFYGTQGDDSLITGKLIENSPHLVl 252
Cdd:PRK10773  186 AAHLEGFGSLAGVAKAKGEIFSGLPENGI-AIMNADSndwLNWQSVIGSKTVWR--FSPNAANSVDFTATNIHVTSHGT- 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 253 EWHEKGSSKTHQVKSNLTGVYNLDNILAAICVGTYLGLTPTEINKGLEGYQPKNNRSQIVKTATNTLICD-YYNANPSSM 331
Cdd:PRK10773  262 EFTLHTPTGSVDVLLPLPGRHNIANALAAAALAMSVGATLDAVKAGLANLKAVPGRLFPIQLAEGQLLLDdSYNANVGSM 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 332 MVAIEnvdkITAEK---KVLILGDMFELGDDAPAEHLAVIEKAEAAGVNERIFIGKeFSAArVSHA---GQYF--ETA-- 401
Cdd:PRK10773  342 TAAAQ----VLAEMpgyRVMVVGDMAELGAESEACHRQVGEAAKAAGIDKVLSVGK-LSHA-ISEAsgvGEHFadKTAli 415

                         410       420       430
                  ....*....|....*....|....*....|.
gi 1928617803 402 EDAIEALQNDPITnaTILIKGSRGMALERLV 432
Cdd:PRK10773  416 ARLKALLAEHQVI--TILVKGSRSAAMEEVV 444
PRK11930 PRK11930
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine ...
 16-435 1.53e-61

putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional


Pssm-ID: 237026 [Multi-domain]  Cd Length: 822  Bit Score: 213.67  E-value: 1.53e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803  16 ISTDTRRI--APGSLFFALKGDKFDANTFAAQAVEAGAAYAVIDDAKYRVSE----QYILVDDVLETLQNLARYHRKQLN 89
Cdd:PRK11930   27 ILTDSRSLsfPENTLFFALKGERNDGHRYIQELYEKGVRNFVVSEEKHPEESypdaNFLKVKDPLKALQELAAYHRSQFD 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803  90 IPVVGLTGTNGKTTTKELINAVLSQHFNTLATQGNLNNHIGVPLTILSITAEHEAAVIEMGANHQKEIEMLCTISQPTHG 169
Cdd:PRK11930  107 IPVIGITGSNGKTIVKEWLYQLLSPDYNIVRSPRSYNSQIGVPLSVWQLNEEHELGIFEAGISQPGEMEALQKIIKPTIG 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 170 LITNVGKAHLEGFGGVEgvKIAKGELydHLATHGANVFINADDATLQQMAAKRTFKKQLF-YGTQGDDSLITGKLIENSP 248
Cdd:PRK11930  187 ILTNIGGAHQENFRSIK--QKIMEKL--KLFKDCDVIIYNGDNELISSCITKSNLTLKLIsWSRKDPEAPLYIPFVEKKE 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 249 HL-VLEWHEKGSSktHQVKSNLTGVYNLDNILAAICVGTYLGLTPTEINKGLEGYQPKNNRSQIVKTATN-TLICDYYNA 326
Cdd:PRK11930  263 DHtVISYTYKGED--FHFEIPFIDDASIENLIHCIAVLLYLGYSADQIQERMARLEPVAMRLEVKEGINNcTLINDSYNS 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 327 NPSSMMVAIENVDKITA-EKKVLILGDMFELGDDAPAEHLAVIEKAEAAGVNERIFIGKEFS--AARVSHAG-QYFETAE 402
Cdd:PRK11930  341 DLQSLDIALDFLNRRSQsKKKTLILSDILQSGQSPEELYRKVAQLISKRGIDRLIGIGEEISseASKFEGTEkEFFKTTE 420

                         410       420       430
                  ....*....|....*....|....*....|...
gi 1928617803 403 DAIEALQNDPITNATILIKGSRGMALERLVALF 435
Cdd:PRK11930  421 AFLKSFAFLKFRNELILVKGARKFEFEQITELL 453
PRK14093 PRK14093
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; ...
 16-432 9.09e-43

UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional


Pssm-ID: 184501 [Multi-domain]  Cd Length: 479  Bit Score: 156.86  E-value: 9.09e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803  16 ISTDTRRIAPGSLFFALKGDKFDANTFAAQAVEAGAAYAVIDDA---KYRVSEQYILVDDVLETLQNLARYHRKQLNIPV 92
Cdd:PRK14093   31 ISIDSRTLAPGDAYFAIKGDVHDGHAFVAAALKAGAALAVVERAqrdKFAADAPLLVVDDVLAALRDLGRAARARLEAKV 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803  93 VGLTGTNGKTTTKELINAVLSQHFNTLATQGNLNNHIGVPLTILSITAEHEAAVIEMGANHQKEIEMLCTISQPTHGLIT 172
Cdd:PRK14093  111 IAVTGSVGKTSTKEALRGVLGAQGETHASVASFNNHWGVPLSLARCPADARFAVFEIGMNHAGEIEPLVKMVRPHVAIIT 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 173 NVGKAHLEGFGGVEGVKIAKGELYDHLATHGANVfINADDAT---LQQMAAKRTFKKQLFYGTQG--DDSLITGKLiens 247
Cdd:PRK14093  191 TVEPVHLEFFSGIEAIADAKAEIFTGLEPGGAAV-LNRDNPQfdrLAASARAAGIARIVSFGADEkaDARLLDVAL---- 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 248 phlvlewHEKGSSKTHQV-------KSNLTGVYNLDNILAAICVGTYLGLTPTEINKGLEGYQPKNNR----SQIVKTAT 316
Cdd:PRK14093  266 -------HADCSAVHADIlghdvtyKLGMPGRHIAMNSLAVLAAAELAGADLALAALALSQVQPAAGRgvrhTLEVGGGE 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 317 NTLICDYYNANPSSMMVAIENVDKITAE---KKVLILGDMFELGDDAPAEHLAVIEKAEAAGVnERIF-----IGKEFSA 388
Cdd:PRK14093  339 ATLIDESYNANPASMAAALGVLGRAPVGpqgRRIAVLGDMLELGPRGPELHRGLAEAIRANAI-DLVFccgplMRNLWDA 417

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 1928617803 389 ARVSHAGQYFETAEdAIEALQNDPITNA-TILIKGSRGMALERLV 432
Cdd:PRK14093  418 LSSGKRGGYAEDAA-ALESQVVAAIRAGdVIMVKGSLGSRMKTIV 461
Mur_ligase_M pfam08245
Mur ligase middle domain;
102-285 5.64e-28

Mur ligase middle domain;


Pssm-ID: 462409 [Multi-domain]  Cd Length: 199  Bit Score: 109.70  E-value: 5.64e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 102 TTTKELINAVLSQHFNTLATQG--------NLNNHIGVPLTILSIT-AEHEAAVIEMGANHQKEiEMLCTISQPTHGLIT 172
Cdd:pfam08245   8 TTTTELIAAILSLAGGVIGTIGtyigksgnTTNNAIGLPLTLAEMVeAGAEYAVLEVSSHGLGE-GRLSGLLKPDIAVFT 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 173 NVGKAHLEGFGGVEGVKIAKGELYDHLATHGAnVFINADD---ATLQQMAAKRTFKKqLFYGTQGDDSLITGKLIENSPH 249
Cdd:pfam08245  87 NISPDHLDFHGTMENYAKAKAELFEGLPEDGI-AVINADDpygAFLIAKLKKAGVRV-ITYGIEGEADLRAANIELSSDG 164

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1928617803 250 LVLEWHEKgSSKTHQVKSNLTGVYNLDNILAAICVG 285
Cdd:pfam08245 165 TSFDLFTV-PGGELEIEIPLLGRHNVYNALAAIAAA 199
PRK11929 PRK11929
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ...
 19-317 4.53e-13

bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;


Pssm-ID: 237025 [Multi-domain]  Cd Length: 958  Bit Score: 71.27  E-value: 4.53e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803  19 DTRRIAPGSLFFALKGDKFDANTFAAQAVEAGAAyAVIDDAKYrVSE------QYILVDDVLETLQNLAR--YHRKQLNI 90
Cdd:PRK11929   35 DSREVQPGDLFVACRGAASDGRAFIDQALARGAA-AVLVEAEG-EDQvaaadaLVLPVADLRKALGELAArwYGRPSEQL 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803  91 PVVGLTGTNGKTTTKELINAVLSQHFNTLATQGNLNNH-----IGVPLTILSITAEHE--AAVIEMGANHqkeiemlCTI 163
Cdd:PRK11929  113 SLVAVTGTNGKTSCAQLLAQLLTRLGKPCGSIGTLGARldgrlIPGSLTTPDAIILHRilARMRAAGADA-------VAM 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 164 SQPTHGL--------------ITNVGKAHLEGFGGVEGVKIAKGELYDHLATHGANVfINADDATLQQMAAKRTFKKQLF 229
Cdd:PRK11929  186 EASSHGLeqgrldglriavagFTNLTRDHLDYHGTMQDYEEAKAALFSKLPGLGAAV-INADDPAAARLLAALPRGLKVG 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 230 YGTQGDDSLITGKLIENSPH---LVLEWHEkgssKTHQVKSNLTGVYNLDNILAAICVGTYLGLTPTEINKGLEGYQPKN 306
Cdd:PRK11929  265 YSPQNAGADVQARDLRATAHgqvFTLATPD----GSYQLVTRLLGRFNVSNLLLVAAALKKLGLPLAQIARALAAVSPVP 340

                         330
                  ....*....|.
gi 1928617803 307 NRSQIVKTATN 317
Cdd:PRK11929  341 GRMERVGPTAG 351
MurE COG0769
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 16-351 5.63e-11

UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440532 [Multi-domain]  Cd Length: 459  Bit Score: 63.94  E-value: 5.63e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803  16 ISTDTRRIAPGSLFFALKGDKFDANTFaaqaveagaayavIDDAKYR-----VSEQ----------YILVDDVLETLQNL 80
Cdd:COG0769     2 ITYDSRKVKPGDLFVALPGARVDGHDF-------------IAQAIARgavavVTEApgallaagvpVIVVPDPRAALALL 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803  81 AR--YHRKQLNIPVVGltgtngktttkeLINAVLSQHFNTLATQGNLNNHIG-----VPLT---------ILSITAEH-- 142
Cdd:COG0769    69 AAafYGHPSQKLKLIGvtgtngkttttyLLAQILRALGKKTGLIGTVGNGIGgelipSSLTtpealdlqrLLAEMVDAgv 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 143 EAAVIEmganhqkeiemlctISqpTHGL--------------ITNVGKAHLEGFGGVEGVKIAKGELYDHLATHGANVfI 208
Cdd:COG0769   149 THVVME--------------VS--SHALdqgrvdgvrfdvavFTNLTRDHLDYHGTMEAYFAAKARLFDQLGPGGAAV-I 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 209 NADDATLQQMAAKRTFKKqLFYGTQGdDSLITGKLIENSPH---LVLEWHEkgssKTHQVKSNLTGVYNLDNILAAICVG 285
Cdd:COG0769   212 NADDPYGRRLAAAAPARV-ITYGLKA-DADLRATDIELSADgtrFTLVTPG----GEVEVRLPLIGRFNVYNALAAIAAA 285

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1928617803 286 TYLGLTPTEINKGLEGYQPKNNRSQIVKTATN-TLICDYynA-NPSSMMVAIENVDKITAEKKVLILG 351
Cdd:COG0769   286 LALGIDLEEILAALEKLKGVPGRMERVDGGQGpTVIVDY--AhTPDALENVLEALRPHTKGRLIVVFG 351
MurD COG0771
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ...
 107-407 7.48e-11

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440534 [Multi-domain]  Cd Length: 445  Bit Score: 63.56  E-value: 7.48e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 107 LINAVLSQH-FNTLATqGNlnnhIGVP-LTILSITAEHEAAVIEMGAnHQkeiemLCTISQ--PTHGLITNVGKAHLEGF 182
Cdd:COG0771   122 LIGHILKAAgLRVAVG-GN----IGTPlLDLLLEPEPPDVYVLELSS-FQ-----LETTPSlrPDVAVILNITPDHLDRH 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 183 GGVEGVKIAKGELYDHlATHGANVFINADDATLQQMaAKRTFKKQLFYGTqgDDSLITGKLIENSpHLVLEWHEKGSSKT 262
Cdd:COG0771   191 GSMEAYAAAKARIFAN-QTPDDYAVLNADDPLTRAL-AEEAKARVVPFSL--KEPLEGGAGLEDG-KLVDRASGEELLPV 265

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 263 HQVKsnLTGVYNLDNILAAICVGTYLGLTPTEINKGLEGYQPKNNRSQIVKTATNTlicDYYN---A-NPSSMMVAIENV 338
Cdd:COG0771   266 DDLR--LPGRHNLENALAALAAARALGVPPEAIREALRSFKGLPHRLEFVAEINGV---RFINdskAtNPDATLAALESF 340

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1928617803 339 DKitaeKKVLILGdmfelGDD--APAEHLA--VIEKAEAAgvnerIFIGK---EFSAARVSHAGQYFETA--EDAIEA 407
Cdd:COG0771   341 DG----PVVLIAG-----GLDkgADFSPLApaVAERVKAV-----VLIGEdaeKIAAALAGAGVPVVIVEtmEEAVAA 404
murE TIGR01085
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ...
 16-351 7.01e-08

UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273435 [Multi-domain]  Cd Length: 464  Bit Score: 54.24  E-value: 7.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803  16 ISTDTRRIAPGSLFFALKGDKFDANTFaAQAVEAGAAYAVIDDAK---YRVSEQYILVDDVLETLQNLAR--YHRKQLNI 90
Cdd:TIGR01085   7 LTLDSREVKPGDLFVAIKGTHVDGHDF-IHDAIANGAVAVVVERDvdfYVAPVPVIIVPDLRHALSSLAAafYGHPSKKL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803  91 PVVGLTGTNGKTTTKELINAVLSQH------FNTLATQGNLNNHIGVP--------LTILSITAEH-----EAAVIEMgA 151
Cdd:TIGR01085  86 KVIGVTGTNGKTTTTSLIAQLLRLLgkktglIGTIGYRLGGNDLIKNPaalttpeaLTLQSTLAEMveagaQYAVMEV-S 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 152 NH---QKEIEmlctisqPTH---GLITNVGKAHLEGFGGVEGVKIAKGELYDHLATHGANVfINADDATLQQMA---AKR 222
Cdd:TIGR01085 165 SHalaQGRVR-------GVRfdaAVFTNLSRDHLDFHGTMENYFAAKASLFTELGLKRFAV-INLDDEYGAQFVkrlPKD 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 223 TF---KKQLFYGTQGDDSLITGKLIENSPHLVLEWhekgSSKTHQVKSNLTGVYNLDNILAAICVG-TYLGLTPTEINKG 298
Cdd:TIGR01085 237 ITvsaITQPADGRAQDIKITDSGYSFEGQQFTFET----PAGEGHLHTPLIGRFNVYNLLAALATLlHLGGIDLEDIVAA 312

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1928617803 299 LEGYQPKNNRSQIVKTATNTLICDYYNANPSSMMVAIENVDKITAEKKVLILG 351
Cdd:TIGR01085 313 LEKFRGVPGRMELVDGGQKFLVIVDYAHTPDALEKALRTLRKHKDGRLIVVFG 365
murE PRK00139
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
 1-351 5.83e-07

UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional


Pssm-ID: 234660 [Multi-domain]  Cd Length: 460  Bit Score: 51.67  E-value: 5.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803   1 MTIDHLYQLYTKHPV--ISTDTRRIAPGSLFFALKGDKFDANTFaaqaveagaayavIDDAKYR-----VSEQ------- 66
Cdd:PRK00139    1 MASMKLRDLLAPVEItgLTYDSRKVKPGDLFVALPGHKVDGRDF-------------IAQAIANgaaavVAEAdgeagtg 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803  67 --YILVDDVLETLQNLAR--YHRKQLNIPVVGltgtngktttkeLINAVLSQHFNTLATQGNLNNHIG---VP--LTils 137
Cdd:PRK00139   68 vpVIIVPDLRKALALLAAafYGHPSDKLKLIGvtgtngktttayLLAQILRLLGEKTALIGTLGNGIGgelIPsgLT--- 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 138 iTAE--------HEAAviEMGANHqkeiemlCTI---SqptHGLI--------------TNVGKAHLEGFGGVEGVKIAK 192
Cdd:PRK00139  145 -TPDaldlqrllAELV--DAGVTY-------AAMevsS---HALDqgrvdglkfdvavfTNLSRDHLDYHGTMEDYLAAK 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 193 GELYDHlatHGANVFINADDATLQQMAAKRTfkkqlFYGTQGDDSLITGKLIENSPHlvlewhekGSSKT--HQVKSNLT 270
Cdd:PRK00139  212 ARLFSE---LGLAAVINADDEVGRRLLALPD-----AYAVSMAGADLRATDVEYTDS--------GQTFTlvTEVESPLI 275

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 271 GVYNLDNILAAICVGTYLGLTPTEINKGLEGYQPKNNRSQIVKTATNTL-ICDYynA-NPSSMMVAIENVDKITAEKKVL 348
Cdd:PRK00139  276 GRFNVSNLLAALAALLALGVPLEDALAALAKLQGVPGRMERVDAGQGPLvIVDY--AhTPDALEKVLEALRPHAKGRLIC 353


                  ...
gi 1928617803 349 ILG 351
Cdd:PRK00139  354 VFG 356
Mur_ligase_C pfam02875
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ...
 308-390 5.67e-06

Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.


Pssm-ID: 460731 [Multi-domain]  Cd Length: 87  Bit Score: 44.26  E-value: 5.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 308 RSQIVKTATNTLICDYYNANPSSMMVAIENVDKITAEKKVLILGDMFELGDDAPAEhLAVIEKAeaagVNERIFIGKEFS 387
Cdd:pfam02875   4 RLEVVGENNGVLVIDDYAHNPDAMEAALRALRNLFPGRLILVFGGMGDRDAEFHAL-LGRLAAA----LADVVILTGDYP 78


                  ...
gi 1928617803 388 AAR 390
Cdd:pfam02875  79 RAE 81
PRK14016 PRK14016
cyanophycin synthetase; Provisional
 169-304 1.01e-04

cyanophycin synthetase; Provisional


Pssm-ID: 237586 [Multi-domain]  Cd Length: 727  Bit Score: 44.76  E-value: 1.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 169 GLITNVGKAHLeGFGGVEGVKiakgELYDHLAT-------HGANVfINADDATLQQMAAkRTFKKQLFYGTQGDDSLIT- 240
Cdd:PRK14016  569 GVVTNIGEDHL-GLGGINTLE----DLAKVKRVvveavkpDGYAV-LNADDPMVAAMAE-RCKGKVIFFSMDPDNPVIAe 641

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1928617803 241 ----GKL---IENsPHLVL---EWHEKGSSkTHQVKSNLTGV--YNLDNILAAICVGTYLGLTPTEINKGLEGYQP 304
Cdd:PRK14016  642 hraqGGRavyVEG-DYIVLaegGWEIRIIS-LADIPLTLGGKagFNIENALAAIAAAWALGIDIELIRAGLRTFVS 715
murD TIGR01087
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ...
 91-419 1.67e-04

UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273436 [Multi-domain]  Cd Length: 433  Bit Score: 43.87  E-value: 1.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803  91 PVVGLTGTNGKTTTKELINAVLSQHFNTLATQGNlnnhIGVPLTILSITAEHEAAVIEMGANHQKEIEMLctisQPTHGL 170
Cdd:TIGR01087 103 PVVAITGTNGKTTTTSLLYHLLKAAGLKAFLGGN----IGTPALEVLDQEGAELYVLELSSFQLETTESL----RPEIAL 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 171 ITNVGKAHLEGFGGVEGVKIAKGELYDHLATHGANVfINADDATLQQMAAKRTFKKQLFYgtqgddslitgklIENSPHL 250
Cdd:TIGR01087 175 ILNISEDHLDWHGSFEDYVAAKLKIFARQTEGDVAV-LNADDPRFARLAQKSKAQVIWFS-------------VEKDAER 240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 251 VLEWHEKGSS-KTHQVKSNLTGVYNLDNILAAICVGTYLGLTPTEINKGLEGYQPKNNRSQIVKTATNTLicdYYN---- 325
Cdd:TIGR01087 241 GLCIRDGGLYlKPNDLEGSLLGLHNAENILAAIALAKSLGLNLEAILEALRSFKGLPHRLEYVGQKNGVH---FYNdska 317

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803 326 ANPSSMMVAIENVDKitaeKKVLILGDMFELGDDAPAEHLAVIEKAEAagvnerIFIG---KEF--SAARVSHAGQYFET 400
Cdd:TIGR01087 318 TNVHATLAALSAFDN----PVILIVGGDDKGADFSPLAPAAAGKVKAV------LAIGedaAKIapLLKEAGLSVYLVES 387

                         330
                  ....*....|....*....
gi 1928617803 401 AEDAIEALQNDPITNATIL 419
Cdd:TIGR01087 388 LEEAVQAAREVASPGDVVL 406
Mur_ligase pfam01225
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes ...
 16-85 1.55e-03

Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.


Pssm-ID: 460121 [Multi-domain]  Cd Length: 84  Bit Score: 37.21  E-value: 1.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1928617803  16 ISTDTRRIAPGSLFFALKGDKFDANTFAAQAVEAGAAYAVIDDAKYRVS----------EQYILVDDVLETLQNLARYHR 85
Cdd:pfam01225   5 VGIDGRGMSPGALFLALKGYRVDGSDFIESLIALGAAAVVGHDAANNISpdnpeleaakVPGIPVIDRREALAELAAAFY 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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