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Conserved domains on  [gi|1860790405|ref|WP_175657848|]
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GNAT family N-acetyltransferase [Burkholderia vietnamiensis]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 18514852)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.1.-
Gene Ontology:  GO:0008080
PubMed:  15581578|9175471|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 82-157 8.89e-09

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


:

Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 50.42  E-value: 8.89e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1860790405  82 VTAQAENEPHRADVAKMLVSRRARRQGIAAKLLAAADHAAREAGKTVLVLDTVTGGD-AERLYERAGWQRVGVVPNY 157
Cdd:COG0456     3 ALLGLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEaAIALYEKLGFEEVGERPNY 79
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
11-175 1.40e-08

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


:

Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 51.53  E-value: 1.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860790405  11 DAREAHAcvDALADVLIDCVEGGASVSFMLPIARATAVAFWkqvaEGVARGERILLVAEDAAaRIVGTVQIVTAQAENEP 90
Cdd:COG1247     6 PATPEDA--PAIAAIYNEAIAEGTATFETEPPSEEEREAWF----AAILAPGRPVLVAEEDG-EVVGFASLGPFRPRPAY 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860790405  91 HRADVAKMLVSRRARRQGIAAKLLAAADHAAREAGKTVLVLDTVTGGD-AERLYERAGWQRVGVVPNYALMpDGTPCATT 169
Cdd:COG1247    79 RGTAEESIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEaSIALYEKLGFEEVGTLPEVGFK-FGRWLDLV 157


                  ....*.
gi 1860790405 170 YFHKQL 175
Cdd:COG1247   158 LMQKRL 163
 
Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 82-157 8.89e-09

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 50.42  E-value: 8.89e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1860790405  82 VTAQAENEPHRADVAKMLVSRRARRQGIAAKLLAAADHAAREAGKTVLVLDTVTGGD-AERLYERAGWQRVGVVPNY 157
Cdd:COG0456     3 ALLGLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEaAIALYEKLGFEEVGERPNY 79
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
11-175 1.40e-08

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 51.53  E-value: 1.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860790405  11 DAREAHAcvDALADVLIDCVEGGASVSFMLPIARATAVAFWkqvaEGVARGERILLVAEDAAaRIVGTVQIVTAQAENEP 90
Cdd:COG1247     6 PATPEDA--PAIAAIYNEAIAEGTATFETEPPSEEEREAWF----AAILAPGRPVLVAEEDG-EVVGFASLGPFRPRPAY 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860790405  91 HRADVAKMLVSRRARRQGIAAKLLAAADHAAREAGKTVLVLDTVTGGD-AERLYERAGWQRVGVVPNYALMpDGTPCATT 169
Cdd:COG1247    79 RGTAEESIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEaSIALYEKLGFEEVGTLPEVGFK-FGRWLDLV 157


                  ....*.
gi 1860790405 170 YFHKQL 175
Cdd:COG1247   158 LMQKRL 163
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 62-150 6.28e-07

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 45.14  E-value: 6.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860790405  62 ERILLVAEDAAaRIVGTVQIVTAQAENEPHRADVAkmlVSRRARRQGIAAKLLAAADHAAREAGKTVLVLDTVTggDAER 141
Cdd:pfam13508   2 GGRFFVAEDDG-KIVGFAALLPLDDEGALAELRLA---VHPEYRGQGIGRALLEAAEAAAKEGGIKLLELETTN--RAAA 75


                  ....*....
gi 1860790405 142 LYERAGWQR 150
Cdd:pfam13508  76 FYEKLGFEE 84
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 52-157 5.60e-04

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 38.08  E-value: 5.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860790405  52 KQVAEGVARGERILLVAEDAAaRIVG--TVQIVtaqaenePHRADVAKMLVSRRARRQGIAAKLLAAADHAAREAGKTVL 129
Cdd:TIGR01575  20 AQFAEELANYHLCYLLARIGG-KVVGyaGVQIV-------LDEAHILNIAVKPEYQGQGIGRALLRELIDEAKGRGVNEI 91

                          90       100
                  ....*....|....*....|....*....
gi 1860790405 130 VLDTVTGGD-AERLYERAGWQRVGVVPNY 157
Cdd:TIGR01575  92 FLEVRVSNIaAQALYKKLGFNEIAIRRNY 120
 
Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 82-157 8.89e-09

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 50.42  E-value: 8.89e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1860790405  82 VTAQAENEPHRADVAKMLVSRRARRQGIAAKLLAAADHAAREAGKTVLVLDTVTGGD-AERLYERAGWQRVGVVPNY 157
Cdd:COG0456     3 ALLGLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEaAIALYEKLGFEEVGERPNY 79
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
11-175 1.40e-08

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 51.53  E-value: 1.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860790405  11 DAREAHAcvDALADVLIDCVEGGASVSFMLPIARATAVAFWkqvaEGVARGERILLVAEDAAaRIVGTVQIVTAQAENEP 90
Cdd:COG1247     6 PATPEDA--PAIAAIYNEAIAEGTATFETEPPSEEEREAWF----AAILAPGRPVLVAEEDG-EVVGFASLGPFRPRPAY 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860790405  91 HRADVAKMLVSRRARRQGIAAKLLAAADHAAREAGKTVLVLDTVTGGD-AERLYERAGWQRVGVVPNYALMpDGTPCATT 169
Cdd:COG1247    79 RGTAEESIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEaSIALYEKLGFEEVGTLPEVGFK-FGRWLDLV 157


                  ....*.
gi 1860790405 170 YFHKQL 175
Cdd:COG1247   158 LMQKRL 163
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 36-161 5.49e-08

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 49.28  E-value: 5.49e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860790405  36 VSFMLPIA--RATAVAFWKQVAEGvargeriLLVAEDAAARIVGtvqIVTAQAENEPHrADVAKMLVSRRARRQGIAAKL 113
Cdd:COG0454    11 INFILLIEalDAELKAMEGSLAGA-------EFIAVDDKGEPIG---FAGLRRLDDKV-LELKRLYVLPEYRGKGIGKAL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1860790405 114 LAAADHAAREAGKTVLVLDTVTGGD-AERLYERAGWQRVGVVPNYALMP 161
Cdd:COG0454    80 LEALLEWARERGCTALELDTLDGNPaAIRFYERLGFKEIERYVAYVGGE 128
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 65-175 5.05e-07

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 46.52  E-value: 5.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860790405  65 LLVAEDAAaRIVGTVQIVTaqaeNEPHRADVAKMLVSRRARRQGIAAKLLAAADHAAREAGKTVLVLDtvTGGDAERLYE 144
Cdd:COG1246    30 FWVAEEDG-EIVGCAALHP----LDEDLAELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLL--TTSAAIHFYE 102

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1860790405 145 RAGWQRVGvvPNYALMPDGTPCATTYFHKQL 175
Cdd:COG1246   103 KLGFEEID--KEDLPYAKVWQRDSVVMEKDL 131
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 62-150 6.28e-07

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 45.14  E-value: 6.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860790405  62 ERILLVAEDAAaRIVGTVQIVTAQAENEPHRADVAkmlVSRRARRQGIAAKLLAAADHAAREAGKTVLVLDTVTggDAER 141
Cdd:pfam13508   2 GGRFFVAEDDG-KIVGFAALLPLDDEGALAELRLA---VHPEYRGQGIGRALLEAAEAAAKEGGIKLLELETTN--RAAA 75


                  ....*....
gi 1860790405 142 LYERAGWQR 150
Cdd:pfam13508  76 FYEKLGFEE 84
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
66-152 3.98e-06

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 44.31  E-value: 3.98e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860790405  66 LVAEDAAaRIVGTVQIVTAQAENEPHRADVAKMLVSRRARRQGIAAKLLAAADHAAREAGKTVLVLDTVTggDAERLYER 145
Cdd:COG3153    42 LVAEDDG-EIVGHVALSPVDIDGEGPALLLGPLAVDPEYRGQGIGRALMRAALEAARERGARAVVLLGDP--SLLPFYER 118


                  ....*..
gi 1860790405 146 AGWQRVG 152
Cdd:COG3153   119 FGFRPAG 125
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 61-148 2.97e-05

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 41.35  E-value: 2.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860790405  61 GERILLVAEDAaaRIVGTVQIVtaQAENEPHRADVAKMLVSRRARRQGIAAKLLAAADHAAREAGKTVLVLDTVTGGD-A 139
Cdd:pfam00583  32 SEGFFVAEEDG--ELVGFASLS--IIDDEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFLEVAADNLaA 107


                  ....*....
gi 1860790405 140 ERLYERAGW 148
Cdd:pfam00583 108 IALYEKLGF 116
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
90-162 2.76e-04

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 37.97  E-value: 2.76e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1860790405  90 PHRADVAKMLVSRRARRQGIAAKLLAAADHAAREAGKTVLVLDTVTG-GDAERLYERAGWQRVGVVPNYALMPD 162
Cdd:COG3393    13 PGVAEISGVYTHPEYRGRGLASALVAALAREALARGARTPFLYVDADnPAARRLYERLGFRPVGEYATVLFRKP 86
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 52-157 5.60e-04

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 38.08  E-value: 5.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860790405  52 KQVAEGVARGERILLVAEDAAaRIVG--TVQIVtaqaenePHRADVAKMLVSRRARRQGIAAKLLAAADHAAREAGKTVL 129
Cdd:TIGR01575  20 AQFAEELANYHLCYLLARIGG-KVVGyaGVQIV-------LDEAHILNIAVKPEYQGQGIGRALLRELIDEAKGRGVNEI 91

                          90       100
                  ....*....|....*....|....*....
gi 1860790405 130 VLDTVTGGD-AERLYERAGWQRVGVVPNY 157
Cdd:TIGR01575  92 FLEVRVSNIaAQALYKKLGFNEIAIRRNY 120
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 1-162 5.49e-03

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 35.75  E-value: 5.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860790405   1 MTEPVTARRVDAREAHACVDALADVLIdcveggASVSFMLPIARATAVAFWKQVAEGVARGERILLVAEDAAA-RIVGTV 79
Cdd:COG1670     4 ETERLRLRPLRPEDAEALAELLNDPEV------ARYLPGPPYSLEEARAWLERLLADWADGGALPFAIEDKEDgELIGVV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860790405  80 QIVtaQAENEPHRADVAkMLVSRRARRQGIAAKLLAA-ADHAAREAGKTVLVLDTVTGGDA-ERLYERAGWQRVGVVPNY 157
Cdd:COG1670    78 GLY--DIDRANRSAEIG-YWLAPAYWGKGYATEALRAlLDYAFEELGLHRVEAEVDPDNTAsIRVLEKLGFRLEGTLRDA 154


                  ....*
gi 1860790405 158 ALMPD 162
Cdd:COG1670   155 LVIDG 159
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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