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Conserved domains on  [gi|1835907492|ref|WP_168977483|]
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MULTISPECIES: NADH-quinone oxidoreductase subunit NuoI [Campylobacter]

Protein Classification

NuoI/complex I 23 kDa subunit family protein( domain architecture ID 11481829)

NuoI/complex I 23 kDa subunit family protein such as bacterial NADH-quinone oxidoreductase subunit I (NuoI), which is part of the connecting domain of complex I of the respiratory chain that couples the transfer of electrons from NADH to quinone with the translocation of protons across the membrane

EC:  7.1.1.-
Gene Ontology:  GO:0016651|GO:0051539|GO:0016020
PubMed:  23417064|33957129|24059520

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK05888 PRK05888
NADH-quinone oxidoreductase subunit NuoI;
21-183 9.27e-65

NADH-quinone oxidoreductase subunit NuoI;


:

Pssm-ID: 235637 [Multi-domain]  Cd Length: 164  Bit Score: 197.41  E-value: 9.27e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835907492  21 ISQALRRSVKLELFVGLFVMMRELLKRnnSATIKYPFEKVKLDNRYRAVHRLMRFiESENERCIGCGLCEKICISNCIRM 100
Cdd:PRK05888    1 IKQYLKSMLLKELLKGLGVTLKYFFKK--KVTIQYPEEKLPLSPRFRGRHALRRD-PNGEERCIACKLCAAICPADAITI 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835907492 101 ETSLDENGRKKVGNYSINLGRCIYCGFCAEVCPELAIVHGIEYENAAEQRSYFGYKQDFLTpidKLKNQVEFEGAGSLRK 180
Cdd:PRK05888   78 EAAEREDGRRRTTRYDINFGRCIFCGFCEEACPTDAIVETPDFELATETREELIYDKEKLL---ANGDRVEREIAPGKAA 154


                  ...
gi 1835907492 181 DAN 183
Cdd:PRK05888  155 DAN 157
 
Name Accession Description Interval E-value
PRK05888 PRK05888
NADH-quinone oxidoreductase subunit NuoI;
21-183 9.27e-65

NADH-quinone oxidoreductase subunit NuoI;


Pssm-ID: 235637 [Multi-domain]  Cd Length: 164  Bit Score: 197.41  E-value: 9.27e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835907492  21 ISQALRRSVKLELFVGLFVMMRELLKRnnSATIKYPFEKVKLDNRYRAVHRLMRFiESENERCIGCGLCEKICISNCIRM 100
Cdd:PRK05888    1 IKQYLKSMLLKELLKGLGVTLKYFFKK--KVTIQYPEEKLPLSPRFRGRHALRRD-PNGEERCIACKLCAAICPADAITI 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835907492 101 ETSLDENGRKKVGNYSINLGRCIYCGFCAEVCPELAIVHGIEYENAAEQRSYFGYKQDFLTpidKLKNQVEFEGAGSLRK 180
Cdd:PRK05888   78 EAAEREDGRRRTTRYDINFGRCIFCGFCEEACPTDAIVETPDFELATETREELIYDKEKLL---ANGDRVEREIAPGKAA 154


                  ...
gi 1835907492 181 DAN 183
Cdd:PRK05888  155 DAN 157
NuoI TIGR01971
NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of ...
 36-160 1.50e-44

NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of the NADH-quinone oxidoreductase complex I which generally couples NADH and ubiquinone oxidation/reduction in bacteria and mammalian mitochondria, but may act on NADPH and/or plastoquinone in cyanobacteria and plant chloroplasts. This model excludes "I" subunits from the closely related F420H2 dehydrogenase and formate hydrogenlyase complexes. [Energy metabolism, Electron transport]


Pssm-ID: 273902 [Multi-domain]  Cd Length: 122  Bit Score: 144.48  E-value: 1.50e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835907492  36 GLFVMMRELLKRnnSATIKYPFEKVKLDNRYRAVHRLMRFIESEnERCIGCGLCEKICISNCIRMETSLDENGRKKVGNY 115
Cdd:TIGR01971   1 GLGLTLKYFFSK--PVTVQYPEEKLYLPPRFRGRIVLTRDPNGE-EKCIGCTLCAAVCPADAIRVVPAEGEDGKRRLKFY 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1835907492 116 SINLGRCIYCGFCAEVCPELAIVHGIEYENAAEQRSYFGYKQDFL 160
Cdd:TIGR01971  78 EINFGRCIFCGLCEEACPTDAIVLTPEFELATYTRSDLVYGKEDL 122
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 81-150 7.72e-20

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 79.40  E-value: 7.72e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835907492  81 ERCIGCGLCEKICISNCIRMETsldengRKKVGNYSINLGRCIYCGFCAEVCPELAIVHGiEYENAAEQR 150
Cdd:COG1143     2 DKCIGCGLCVRVCPVDAITIED------GEPGKVYVIDPDKCIGCGLCVEVCPTGAISMT-PFELAVEDR 64
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 76-137 1.45e-14

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 67.42  E-value: 1.45e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1835907492  76 IESENERCIGCGLCEKICISNCIRMEtsldeNGRKKVGNYSINLGRCIYCGFCAEVCPELAI 137
Cdd:cd10549     1 LKYDPEKCIGCGICVKACPTDAIELG-----PNGAIARGPEIDEDKCVFCGACVEVCPTGAI 57
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 83-133 4.80e-11

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 56.00  E-value: 4.80e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1835907492  83 CIGCGLCEKICISNCIRMETSLDENGRKKVgnySINLGRCIYCGFCAEVCP 133
Cdd:pfam12838   1 CIGCGACVAACPVGAITLDEVGEKKGTKTV---VIDPERCVGCGACVAVCP 48
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 80-140 7.98e-07

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 47.93  E-value: 7.98e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1835907492  80 NERCIGCGLCEKICISNCIRMetsldENGRKKVGNysinlgRCIYCGFCAEVCPELAIVHG 140
Cdd:NF038196  184 TDKCIGCGICAKVCPVNNIEM-----EDGKPVWGH------NCTHCLACIHRCPKEAIEYG 233
 
Name Accession Description Interval E-value
PRK05888 PRK05888
NADH-quinone oxidoreductase subunit NuoI;
21-183 9.27e-65

NADH-quinone oxidoreductase subunit NuoI;


Pssm-ID: 235637 [Multi-domain]  Cd Length: 164  Bit Score: 197.41  E-value: 9.27e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835907492  21 ISQALRRSVKLELFVGLFVMMRELLKRnnSATIKYPFEKVKLDNRYRAVHRLMRFiESENERCIGCGLCEKICISNCIRM 100
Cdd:PRK05888    1 IKQYLKSMLLKELLKGLGVTLKYFFKK--KVTIQYPEEKLPLSPRFRGRHALRRD-PNGEERCIACKLCAAICPADAITI 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835907492 101 ETSLDENGRKKVGNYSINLGRCIYCGFCAEVCPELAIVHGIEYENAAEQRSYFGYKQDFLTpidKLKNQVEFEGAGSLRK 180
Cdd:PRK05888   78 EAAEREDGRRRTTRYDINFGRCIFCGFCEEACPTDAIVETPDFELATETREELIYDKEKLL---ANGDRVEREIAPGKAA 154


                  ...
gi 1835907492 181 DAN 183
Cdd:PRK05888  155 DAN 157
NuoI TIGR01971
NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of ...
 36-160 1.50e-44

NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of the NADH-quinone oxidoreductase complex I which generally couples NADH and ubiquinone oxidation/reduction in bacteria and mammalian mitochondria, but may act on NADPH and/or plastoquinone in cyanobacteria and plant chloroplasts. This model excludes "I" subunits from the closely related F420H2 dehydrogenase and formate hydrogenlyase complexes. [Energy metabolism, Electron transport]


Pssm-ID: 273902 [Multi-domain]  Cd Length: 122  Bit Score: 144.48  E-value: 1.50e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835907492  36 GLFVMMRELLKRnnSATIKYPFEKVKLDNRYRAVHRLMRFIESEnERCIGCGLCEKICISNCIRMETSLDENGRKKVGNY 115
Cdd:TIGR01971   1 GLGLTLKYFFSK--PVTVQYPEEKLYLPPRFRGRIVLTRDPNGE-EKCIGCTLCAAVCPADAIRVVPAEGEDGKRRLKFY 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1835907492 116 SINLGRCIYCGFCAEVCPELAIVHGIEYENAAEQRSYFGYKQDFL 160
Cdd:TIGR01971  78 EINFGRCIFCGLCEEACPTDAIVLTPEFELATYTRSDLVYGKEDL 122
PRK12387 PRK12387
formate hydrogenlyase complex iron-sulfur subunit; Provisional
 40-159 2.02e-21

formate hydrogenlyase complex iron-sulfur subunit; Provisional


Pssm-ID: 183492 [Multi-domain]  Cd Length: 180  Bit Score: 87.01  E-value: 2.02e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835907492  40 MMReLLK---RNNSATIKYPFEKVKLDNRYRAVHrlmrfiESENERCIGCGLCEKICISNCIRMETSLDENGRKkvgnYS 116
Cdd:PRK12387    1 MFK-LIKkviKTGTATSSYPLEPIAVDKNFRGKP------EYNPQQCIGCAACVNACPSNALTVETDLATGELA----WE 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1835907492 117 INLGRCIYCGFCAEVCPELAIVHGIEYENAAEQRSYFGYKQDF 159
Cdd:PRK12387   70 FNLGRCIFCGRCEEVCPTAAIKLSQEFELAVWKKEDLLQQSEF 112
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 81-150 7.72e-20

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 79.40  E-value: 7.72e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835907492  81 ERCIGCGLCEKICISNCIRMETsldengRKKVGNYSINLGRCIYCGFCAEVCPELAIVHGiEYENAAEQR 150
Cdd:COG1143     2 DKCIGCGLCVRVCPVDAITIED------GEPGKVYVIDPDKCIGCGLCVEVCPTGAISMT-PFELAVEDR 64
PRK08222 PRK08222
hydrogenase 4 subunit H; Validated
 41-151 1.29e-17

hydrogenase 4 subunit H; Validated


Pssm-ID: 181301 [Multi-domain]  Cd Length: 181  Bit Score: 77.10  E-value: 1.29e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835907492  41 MRELLK---RNNSATIKYPFEKVKLDNRYRAVHRLMRfiesenERCIGCGLCEKICISNCIRMETSLDENGRkkvgNYSI 117
Cdd:PRK08222    1 MLKLLKtimRAGTATVKYPFAPLEVSPGFRGKPDLMP------SQCIACGACTCACPANALTIQTDDQQNSR----TWQL 70

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1835907492 118 NLGRCIYCGFCAEVCPELAIVHGIEYENAAEQRS 151
Cdd:PRK08222   71 YLGRCIYCGRCEEVCPTRAIQLTNNFELTVTNKA 104
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 76-137 1.45e-14

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 67.42  E-value: 1.45e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1835907492  76 IESENERCIGCGLCEKICISNCIRMEtsldeNGRKKVGNYSINLGRCIYCGFCAEVCPELAI 137
Cdd:cd10549     1 LKYDPEKCIGCGICVKACPTDAIELG-----PNGAIARGPEIDEDKCVFCGACVEVCPTGAI 57
ndhI CHL00014
NADH dehydrogenase subunit I
 52-157 3.50e-14

NADH dehydrogenase subunit I


Pssm-ID: 214334 [Multi-domain]  Cd Length: 167  Bit Score: 67.48  E-value: 3.50e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835907492  52 TIKYPFEKVKLDNRYRAVhrlmrfIESENERCIGCGLCEKICISNCIRMETSLDENGRKK-VGNYSINLGRCIYCGFCAE 130
Cdd:CHL00014   36 TIQYPYEKLITSERFRGR------IHFEFDKCIACEVCVRVCPIDLPVVDWKLETDIRKKrLLNYSIDFGVCIFCGNCVE 109

                          90       100
                  ....*....|....*....|....*..
gi 1835907492 131 VCPELAIVHGIEYENAAEQRSYFGYKQ 157
Cdd:CHL00014  110 YCPTNCLSMTEEYELSTYDRHELNYNQ 136
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 81-137 1.48e-12

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 60.45  E-value: 1.48e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1835907492  81 ERCIGCGLCEKICISNCIRMETsldengrkkvGNYSINLGRCIYCGFCAEVCPELAI 137
Cdd:COG2221    15 EKCIGCGLCVAVCPTGAISLDD----------GKLVIDEEKCIGCGACIRVCPTGAI 61
PRK13984 PRK13984
putative oxidoreductase; Provisional
 52-132 2.06e-12

putative oxidoreductase; Provisional


Pssm-ID: 172486 [Multi-domain]  Cd Length: 604  Bit Score: 65.17  E-value: 2.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835907492  52 TIKYPFEKVKLDNRYRAVHRlmrfieSENERCIGCGLCEKICISNCIRM--ETSLDENGRKKVGNYSINLGRCIYCGFCA 129
Cdd:PRK13984   22 TIKVPNVKREAAERYRGFHI------NDWEKCIGCGTCSKICPTDAITMveVPDLPQEYGKKPQRPVIDYGRCSFCALCV 95


                  ...
gi 1835907492 130 EVC 132
Cdd:PRK13984   96 DIC 98
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
70-150 2.11e-12

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 60.13  E-value: 2.11e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835907492  70 HRLMRFIESEnERCIGCGLCEKICISNCIRMETsldengrkkvGNYSINLGRCIYCGFCAEVCPELAIVHGIEYENAAEQ 149
Cdd:COG2768     1 HSLGKPYVDE-EKCIGCGACVKVCPVGAISIED----------GKAVIDPEKCIGCGACIEVCPVGAIKIEWEEDEEFQE 69


                  .
gi 1835907492 150 R 150
Cdd:COG2768    70 K 70
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 56-138 3.37e-12

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 61.26  E-value: 3.37e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835907492  56 PFEKVKLDNRYRAVHRLMRFIESENERCIGCGLCEKICISNCIRMETSLdengrkkvgNYSINLGRCIYCGFCAEVCPEL 135
Cdd:cd10549    53 PTGAIELTPEGKEYVPKEKEAEIDEEKCIGCGLCVKVCPVDAITLEDEL---------EIVIDKEKCIGCGICAEVCPVN 123


                  ...
gi 1835907492 136 AIV 138
Cdd:cd10549   124 AIK 126
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 73-137 4.86e-12

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 58.97  E-value: 4.86e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1835907492  73 MRFIESENERCIGCGLCEKICISNCIRMEtsldengrkKVGNYSINLGRCIYCGFCAEVCPELAI 137
Cdd:COG1149     3 RKIPVIDEEKCIGCGLCVEVCPEGAIKLD---------DGGAPVVDPDLCTGCGACVGVCPTGAI 58
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 56-139 1.10e-11

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 58.52  E-value: 1.10e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835907492  56 PFEKVKLDNRYRAvhrlMRFiESENERCIGCGLCEKICISNCIrmetslDENGRKkvgnYSINLGRCIYCGFCAEVCPEL 135
Cdd:COG4231     2 NITVKILDNRTTA----MRY-VIDEDKCTGCGACVKVCPADAI------EEGDGK----AVIDPDLCIGCGSCVQVCPVD 66


                  ....
gi 1835907492 136 AIVH 139
Cdd:COG4231    67 AIKL 70
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 81-137 2.04e-11

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 58.95  E-value: 2.04e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1835907492  81 ERCIGCGLCEKICISNCIRMETSLDENgRKKVGNYSINLGRCIYCGFCAEVCPELAI 137
Cdd:cd10549    40 DKCVFCGACVEVCPTGAIELTPEGKEY-VPKEKEAEIDEEKCIGCGLCVKVCPVDAI 95
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 81-144 3.62e-11

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 56.64  E-value: 3.62e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1835907492  81 ERCIGCGLCEKICISNCIRMEtslDENGRKKVgnysINLGRCIYCGFCAEVCPELAIVHGIEYE 144
Cdd:COG1146     8 DKCIGCGACVEVCPVDVLELD---EEGKKALV----INPEECIGCGACELVCPVGAITVEDDEP 64
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 83-133 4.80e-11

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 56.00  E-value: 4.80e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1835907492  83 CIGCGLCEKICISNCIRMETSLDENGRKKVgnySINLGRCIYCGFCAEVCP 133
Cdd:pfam12838   1 CIGCGACVAACPVGAITLDEVGEKKGTKTV---VIDPERCVGCGACVAVCP 48
NapF COG1145
Ferredoxin [Energy production and conversion];
33-139 9.24e-11

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 59.35  E-value: 9.24e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835907492  33 LFVGLFVMMRELLKRNNSATIKYPFEKVKLDNRYRAVHRLMRFIESE--NERCIGCGLCEKICISNCIRMEtsldengrK 110
Cdd:COG1145   132 LLVIAAALAEAGLAILGAAAPVDALAISGGKKIEEELKIAIKKAKAVidAEKCIGCGLCVKVCPTGAIRLK--------D 203

                          90       100
                  ....*....|....*....|....*....
gi 1835907492 111 KVGNYSINLGRCIYCGFCAEVCPELAIVH 139
Cdd:COG1145   204 GKPQIVVDPDKCIGCGACVKVCPVGAISL 232
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 81-138 3.05e-10

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 54.67  E-value: 3.05e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1835907492  81 ERCIGCGLCEKICISNCIRMEtsldeNGRKkvgnYSINLGRCIYCGFCAEVCPELAIV 138
Cdd:COG1144    30 DKCIGCGLCWIVCPDGAIRVD-----DGKY----YGIDYDYCKGCGICAEVCPVKAIE 78
PRK13795 PRK13795
hypothetical protein; Provisional
 53-133 1.25e-09

hypothetical protein; Provisional


Pssm-ID: 237510 [Multi-domain]  Cd Length: 636  Bit Score: 57.31  E-value: 1.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835907492  53 IKYPFEKVKLDNRYRAVHRLMRfiesENERCIGCGLCEKICISNCIRMetsldENGRKKVgnySINLGRCIYCGFCAEVC 132
Cdd:PRK13795  557 WARSEDKEAAASLFKDAARLLR----RAAECVGCGVCVGACPTGAIRI-----EEGKRKI---SVDEEKCIHCGKCTEVC 624


                  .
gi 1835907492 133 P 133
Cdd:PRK13795  625 P 625
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
83-139 8.77e-09

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 54.17  E-value: 8.77e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1835907492  83 CIGCGLCEKICISNCIRMETSLDEngrkkvgnysINLGRCIYCGFCAEVCPELAIVH 139
Cdd:PRK07118  215 CIGCGKCVKACPAGAITMENNLAV----------IDQEKCTSCGKCVEKCPTKAIRI 261
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 82-139 4.32e-07

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 47.64  E-value: 4.32e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1835907492  82 RCIGCGLCEKICISNCIRMETSLD--ENGRKKVGNYsiNLGRCIYCG-FCAEVCPELAIVH 139
Cdd:cd16373    15 LCIRCGLCVEACPTGVIQPAGLEDglEGGRTPYLDP--REGPCDLCCdACVEVCPTGALRP 73
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 80-140 7.98e-07

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 47.93  E-value: 7.98e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1835907492  80 NERCIGCGLCEKICISNCIRMetsldENGRKKVGNysinlgRCIYCGFCAEVCPELAIVHG 140
Cdd:NF038196  184 TDKCIGCGICAKVCPVNNIEM-----EDGKPVWGH------NCTHCLACIHRCPKEAIEYG 233
PRK08348 PRK08348
NADH-plastoquinone oxidoreductase subunit; Provisional
 81-162 8.64e-07

NADH-plastoquinone oxidoreductase subunit; Provisional


Pssm-ID: 181399 [Multi-domain]  Cd Length: 120  Bit Score: 46.37  E-value: 8.64e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835907492  81 ERCIGCGLCEKICISNCIRMETSLdengrKKVgnySINLGRCIYCGFCAEVCPELAIVHGIEYENAAEQRsyFGYKQDFL 160
Cdd:PRK08348   42 DKCVGCRMCVTVCPAGVFVYLPEI-----RKV---ALWTGRCVFCGQCVDVCPTGALQMSDDFLLASYDR--FDEKFIPL 111


                  ..
gi 1835907492 161 TP 162
Cdd:PRK08348  112 KP 113
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
81-137 8.66e-07

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 48.70  E-value: 8.66e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1835907492  81 ERCIGCGLCEKICISNCIRMetsldengrKKVGNYSINLGRCIYCGFCAEVCPELAI 137
Cdd:COG1148   496 EKCTGCGRCVEVCPYGAISI---------DEKGVAEVNPALCKGCGTCAAACPSGAI 543
Fer4_10 pfam13237
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 81-133 9.48e-07

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 404174 [Multi-domain]  Cd Length: 56  Bit Score: 44.55  E-value: 9.48e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1835907492  81 ERCIGCGLCEKICISNCIRMETSLDENGRKKVgnySINLGRCIYCGFCAEVCP 133
Cdd:pfam13237   7 DKCIGCGRCTAACPAGLTRVGAIVERLEGEAV---RIGVWKCIGCGACVEACP 56
DMSOR_beta_like cd16370
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 81-133 1.18e-06

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319892 [Multi-domain]  Cd Length: 131  Bit Score: 46.11  E-value: 1.18e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1835907492  81 ERCIGCGLCEKICISNCIRMetslDENGRKKVgnysinlgRCIYCGFCAEVCP 133
Cdd:cd16370    83 EKCIGCGNCVKACIVGAIFW----DEETNKPI--------ICIHCGYCARYCP 123
NapH COG0348
Polyferredoxin NapH [Energy production and conversion];
81-137 2.81e-06

Polyferredoxin NapH [Energy production and conversion];


Pssm-ID: 440117 [Multi-domain]  Cd Length: 263  Bit Score: 46.59  E-value: 2.81e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1835907492  81 ERCIGCGLCEKICisncirmETSLDengrkkVGNYSINLGRCIYCGFCAEVCPELAI 137
Cdd:COG0348   210 GDCIDCGLCVKVC-------PMGID------IRKGEINQSECINCGRCIDACPKDAI 253
DMSOR_beta_like cd16372
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 74-137 2.93e-06

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319894 [Multi-domain]  Cd Length: 125  Bit Score: 45.02  E-value: 2.93e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1835907492  74 RFIESENERCIGCGLCEKICIS----------NCIRMEtsldengrKKVGNYSINLgrCIYCGFCAEVCPELAI 137
Cdd:cd16372     1 KLLVTDPEKCIGCLQCEEACSKtffkeedrekSCIRIT--------ETEGGYAINV--CNQCGECIDVCPTGAI 64
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
81-133 5.09e-06

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 46.17  E-value: 5.09e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1835907492  81 ERCIGCGLCEKICISNCIRMEtsldeNGRKKvgnysINLGRCIYCGFCAEVCP 133
Cdd:COG4624    91 EKCKNCYPCVRACPVKAIKVD-----DGKAE-----IDEEKCISCGQCVAVCP 133
PRK12771 PRK12771
putative glutamate synthase (NADPH) small subunit; Provisional
 79-142 1.29e-05

putative glutamate synthase (NADPH) small subunit; Provisional


Pssm-ID: 237198 [Multi-domain]  Cd Length: 564  Bit Score: 45.25  E-value: 1.29e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1835907492  79 ENERCIGCGLCE--KICISNCirmetslDENGRKKVG---NYSINLGRCIYCGFCAEVCPELAIVHGIE 142
Cdd:PRK12771  502 EAARCLSCGNCFecDNCYGAC-------PQDAIIKLGpgrRYHFDYDKCTGCHICADVCPCGAIEMGPG 563
NapF_like cd10564
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ...
 81-137 1.42e-05

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319886 [Multi-domain]  Cd Length: 139  Bit Score: 43.39  E-value: 1.42e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1835907492  81 ERCIGCGLCEKICISNCIRmetsLDENGRKKVgnySINLGRCIYCGFCAEVCPELAI 137
Cdd:cd10564    13 DLCTRCGDCVEACPEGIIV----RGDGGFPEL---DFSRGECTFCGACAEACPEGAL 62
Fer4_9 pfam13187
4Fe-4S dicluster domain;
82-137 2.35e-05

4Fe-4S dicluster domain;


Pssm-ID: 463801 [Multi-domain]  Cd Length: 50  Bit Score: 40.61  E-value: 2.35e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1835907492  82 RCIGCGLCEKICISNCIRMetsldENGRKKVGNYSINLgRCIYCGFCAEVCPELAI 137
Cdd:pfam13187   1 KCTGCGACVAACPAGAIVP-----DLVGQTIRGDIAGL-ACIGCGACVDACPRGAI 50
ACS_1 cd01916
Acetyl-CoA synthase (ACS), also known as acetyl-CoA decarbonylase, is found in acetogenic and ...
 70-152 7.82e-05

Acetyl-CoA synthase (ACS), also known as acetyl-CoA decarbonylase, is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA. ACS forms a heterotetramer with carbon monoxide dehydrogenase (CODH) consisting of two ACS and two CODH subunits. CODH reduces carbon dioxide to carbon monoxide and ACS then synthesizes acetyl-CoA from carbon monoxide, CoA, and a methyl group donated by another protein (CoFeSP). ACS has three structural domains, an N-terminal rossman fold domain with a helical region at its N-terminus which interacts with CODH, and two alpha + beta fold domains. A Ni-Fe-S center referred to as the A-cluster is located in the C-terminal domain. A large cavity exists between the three domains which may bind CoA.


Pssm-ID: 238897 [Multi-domain]  Cd Length: 731  Bit Score: 42.78  E-value: 7.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835907492  70 HRLMRFIESENE------RCIGCGLCEKICiSNCIRMEtslDENGRKKVGNYS--INL-GRCIYCGFCAEVCP-ELAIVH 139
Cdd:cd01916   348 RKGEKKLPTDEEfqelaaKCTDCGWCTRAC-PNSLRIK---EAMEAAKEGDFSglADLfDQCVGCGRCEQECPkEIPIIN 423

                          90
                  ....*....|...
gi 1835907492 140 GIEYenAAEQRSY 152
Cdd:cd01916   424 MIEK--AARERIK 434
FDH_b_like cd10562
uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes ...
 72-133 1.36e-04

uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes the beta-subunit of formate dehydrogenases that are as yet uncharacterized. Members of the DMSO reductase family include formate dehydrogenase N and O (FDH-N, FDH-O) and tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N, a major component of nitrate respiration of Escherichia coli, is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. It forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons.


Pssm-ID: 319884 [Multi-domain]  Cd Length: 161  Bit Score: 40.75  E-value: 1.36e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1835907492  72 LMRFIESENE-----------RCIGCG--LCEKICISNCIRmetsldengRKKVGNYSINLGRCIYCGFCAEVCP 133
Cdd:cd10562    48 LIRFYEHEEDnggirwlfrkrQCMHCTdaACVKVCPTGALY---------KTENGAVVVDEDKCIGCGYCVAACP 113
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
 81-152 2.01e-04

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 41.13  E-value: 2.01e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1835907492  81 ERCIGCGLCEKICISNCIRM---ETSLDENGRKKVGNYSINLGrCIycGFCAEVCPELAIvhgIEYENAAEQRSY 152
Cdd:COG2878   167 DKCTGCGLCVEACPVDCIEMvpvSPTVVVSSWDKGKAVRKVVG-CI--GLCCKKCCPAAA---ITVNNLAAIIDY 235
napF TIGR00402
ferredoxin-type protein NapF; The gene codes for a ferredoxin-type cytosolic protein, NapF, of ...
 82-134 2.06e-04

ferredoxin-type protein NapF; The gene codes for a ferredoxin-type cytosolic protein, NapF, of the periplasmic nitrate reductase system, as in Escherichia coli. NapF interacts with the catalytic subunit, NapA, and may be an accessory protein for NapA maturation. [Energy metabolism, Electron transport]


Pssm-ID: 273060 [Multi-domain]  Cd Length: 101  Bit Score: 39.16  E-value: 2.06e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1835907492  82 RCIGCGLCEKICISNCIRmetsldengRKKVGNYSINL--GRCIYCGFCAEVCPE 134
Cdd:TIGR00402  35 VCTRCGECASACENNILQ---------LGQQGQPTVEFdnAECDFCGKCAEACPT 80
PRK06273 PRK06273
ferredoxin; Provisional
 80-133 2.59e-04

ferredoxin; Provisional


Pssm-ID: 235764 [Multi-domain]  Cd Length: 165  Bit Score: 40.08  E-value: 2.59e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835907492  80 NERCIGCGLCEKICISNCIRMEtslDENGRKKVGNYS------INLGRCIYCGFCAEVCP 133
Cdd:PRK06273   48 EELCIGCGGCANVCPTKAIEMI---PVEPVKITEGYVktkipkIDYEKCVYCLYCHDFCP 104
Fer4 pfam00037
4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to ...
 115-137 2.89e-04

4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 459642 [Multi-domain]  Cd Length: 24  Bit Score: 36.84  E-value: 2.89e-04
                          10        20
                  ....*....|....*....|...
gi 1835907492 115 YSINLGRCIYCGFCAEVCPELAI 137
Cdd:pfam00037   1 VVIDEEKCIGCGACVEVCPVGAI 23
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
74-137 2.90e-04

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 39.64  E-value: 2.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835907492  74 RFIESENERCIGCGLCEKIC-----------ISNCIRMETSLD----------ENG-----------RKKVGNYSINLGR 121
Cdd:COG1142     3 KFIIADPEKCIGCRTCEAACavahegeegepFLPRIRVVRKAGvsapvqcrhcEDApcaevcpvgaiTRDDGAVVVDEEK 82

                          90
                  ....*....|....*.
gi 1835907492 122 CIYCGFCAEVCPELAI 137
Cdd:COG1142    83 CIGCGLCVLACPFGAI 98
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
81-138 5.19e-04

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 38.87  E-value: 5.19e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1835907492  81 ERCIGCGLCEKICISNCIRMETsldENGRKKVgnysinlGRCIYCGF------CAEVCPELAIV 138
Cdd:COG1142    81 EKCIGCGLCVLACPFGAITMVG---EKSRAVA-------VKCDLCGGreggpaCVEACPTGALR 134
PRK09898 PRK09898
ferredoxin-like protein;
76-145 5.34e-04

ferredoxin-like protein;


Pssm-ID: 182135 [Multi-domain]  Cd Length: 208  Bit Score: 39.43  E-value: 5.34e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835907492  76 IESENERCIGCGlcekICISNCIRMETSLDENGRKKvgnysinlGRCIYCGFCAEVCPELAIvHGIEYEN 145
Cdd:PRK09898  149 ITVDHKRCIGCS----ACTTACPWMMATVNTESKKS--------SKCVLCGECANACPTGAL-KIIEWKD 205
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
 83-133 6.42e-04

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 39.59  E-value: 6.42e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1835907492  83 CIGCGLCEKICISNCIRMetslDENGRKKVgnysiNLGRCIYCGFCAEVCP 133
Cdd:COG2878   139 CIGCGDCIKACPFDAIVG----AAKGMHTV-----DEDKCTGCGLCVEACP 180
SIMIBI_bact_arch cd03110
bacterial and archaeal subfamily of SIMIBI; Uncharacterized bacterial and archaeal subfamily ...
 80-137 6.91e-04

bacterial and archaeal subfamily of SIMIBI; Uncharacterized bacterial and archaeal subfamily of SIMIBI superfamily. Proteins in this superfamily contain an ATP-binding domain and use energy from hydrolysis of ATP to transfer electron or ion. The specific function of this family is unknown.


Pssm-ID: 349764 [Multi-domain]  Cd Length: 246  Bit Score: 39.29  E-value: 6.91e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1835907492  80 NERCIGCGLCEKICISNCIrmetsldengrKKVGNYS-INLGRCIYCGFCAEVCPELAI 137
Cdd:cd03110    63 QEKCIRCGNCERVCKFGAI-----------LEFFQKLiVDESLCEGCGACVIICPRGAI 110
PRK08318 PRK08318
NAD-dependent dihydropyrimidine dehydrogenase subunit PreA;
62-133 8.35e-04

NAD-dependent dihydropyrimidine dehydrogenase subunit PreA;


Pssm-ID: 236237 [Multi-domain]  Cd Length: 420  Bit Score: 39.54  E-value: 8.35e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1835907492  62 LDNRYRAVHRLmrfiesENERCIGCGLCEKICisncirMETS-----LDENGRKKvgnYSINLGRCIYCGFCAEVCP 133
Cdd:PRK08318  329 LDLNYIVYARI------DQDKCIGCGRCYIAC------EDTShqaieWDEDGTRT---PEVIEEECVGCNLCAHVCP 390
NapF COG1145
Ferredoxin [Energy production and conversion];
76-140 9.78e-04

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 38.94  E-value: 9.78e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1835907492  76 IESENERCIGCGLCEKICISNCIRMETSLDENGRKKVGNYSINLGRCIYCGFCAEVCPELAIVHG 140
Cdd:COG1145   138 ALAEAGLAILGAAAPVDALAISGGKKIEEELKIAIKKAKAVIDAEKCIGCGLCVKVCPTGAIRLK 202
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 117-140 1.47e-03

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 35.86  E-value: 1.47e-03
                          10        20
                  ....*....|....*....|....
gi 1835907492 117 INLGRCIYCGFCAEVCPELAIVHG 140
Cdd:COG1149     8 IDEEKCIGCGLCVEVCPEGAIKLD 31
Fer4_8 pfam13183
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 82-133 1.58e-03

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 433017 [Multi-domain]  Cd Length: 64  Bit Score: 35.75  E-value: 1.58e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1835907492  82 RCIGCGLCEKIC---------ISNCIRMETSLDENGRKKVGNYSINLGRCIYCGFCAEVCP 133
Cdd:pfam13183   1 RCIRCGACLAACpvylvtggrFPGDPRGGAAALLGRLEALEGLAEGLWLCTLCGACTEVCP 61
DMSOR_beta_like cd10550
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 81-137 1.87e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319872 [Multi-domain]  Cd Length: 130  Bit Score: 37.17  E-value: 1.87e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835907492  81 ERCIGCGLCEKICISNCIRMETsldengrkkVGNYSInlgRCIYCG---FCAEVCPELAI 137
Cdd:cd10550    80 DKCIGCGMCVEACPFGAIRVDP---------ETGKAI---KCDLCGgdpACVKVCPTGAL 127
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 81-106 2.78e-03

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 35.07  E-value: 2.78e-03
                          10        20
                  ....*....|....*....|....*.
gi 1835907492  81 ERCIGCGLCEKICISNCIRMETSLDE 106
Cdd:COG1146    40 EECIGCGACELVCPVGAITVEDDEPE 65
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 81-101 3.42e-03

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 35.41  E-value: 3.42e-03
                          10        20
                  ....*....|....*....|.
gi 1835907492  81 ERCIGCGLCEKICISNCIRME 101
Cdd:COG1144    60 DYCKGCGICAEVCPVKAIEMV 80
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 81-137 4.10e-03

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 36.21  E-value: 4.10e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1835907492  81 ERCIGCGLCEKICiSNCIRMETSLDENGRKKVGNYSINLG----RCIYCGF--CAEVCPELAI 137
Cdd:cd04410     6 DRCIGCGTCEVAC-KQEHGLRPGPDWSRIKVIEGGGLERAflpvSCMHCEDppCVKACPTGAI 67
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
83-133 4.50e-03

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 37.22  E-value: 4.50e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1835907492  83 CIGCGLCEKICISNCIRMETSLDEngrkkvgnysINLGRCIYCGFCAEVCP 133
Cdd:PRK07118  141 CLGLGSCVAACPFDAIHIENGLPV----------VDEDKCTGCGACVKACP 181
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 81-101 4.94e-03

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 34.70  E-value: 4.94e-03
                          10        20
                  ....*....|....*....|.
gi 1835907492  81 ERCIGCGLCEKICISNCIRME 101
Cdd:COG1149    41 DLCTGCGACVGVCPTGAITLE 61
Fer4_21 pfam14697
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 81-133 5.78e-03

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 434137 [Multi-domain]  Cd Length: 59  Bit Score: 34.18  E-value: 5.78e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1835907492  81 ERCIGCGLCEKICISNCI--------RMETSLDENgrkkvgnysinlgrCIYCGFCAEVCP 133
Cdd:pfam14697   6 DTCIGCGKCYIACPDTSHqaivgdgkRHHTVIEDE--------------CTGCNLCVSVCP 52
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 81-101 6.14e-03

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 34.63  E-value: 6.14e-03
                          10        20
                  ....*....|....*....|.
gi 1835907492  81 ERCIGCGLCEKICISNCIRME 101
Cdd:COG4231    51 DLCIGCGSCVQVCPVDAIKLE 71
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 81-99 7.05e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 35.69  E-value: 7.05e-03
                          10
                  ....*....|....*....
gi 1835907492  81 ERCIGCGLCEKICISNCIR 99
Cdd:cd16373   130 DKCVGCGLCEYVCPVEPPK 148
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
40-137 7.36e-03

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 36.93  E-value: 7.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835907492  40 MMRELLKRNNSATIKYPFEKVKLDNRYRAVHRLMRFIESENERCIGCGLCEKICISNCIRMETSLDENGRKKVGNYSINL 119
Cdd:COG4624    11 CCIEEGDELLLLEEAERVLRIIILEALLPEHVDDDSACSCCPRCCLCCCCCCRCCVAISCIQVRGIIIIDKRGPSIIRDK 90

                          90
                  ....*....|....*...
gi 1835907492 120 GRCIYCGFCAEVCPELAI 137
Cdd:COG4624    91 EKCKNCYPCVRACPVKAI 108
Fer4 pfam00037
4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to ...
 81-99 9.22e-03

4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 459642 [Multi-domain]  Cd Length: 24  Bit Score: 32.61  E-value: 9.22e-03
                          10
                  ....*....|....*....
gi 1835907492  81 ERCIGCGLCEKICISNCIR 99
Cdd:pfam00037   6 EKCIGCGACVEVCPVGAIT 24
NapF COG1145
Ferredoxin [Energy production and conversion];
81-102 9.31e-03

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 36.24  E-value: 9.31e-03
                          10        20
                  ....*....|....*....|..
gi 1835907492  81 ERCIGCGLCEKICISNCIRMET 102
Cdd:COG1145   213 DKCIGCGACVKVCPVGAISLEP 234
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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