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Conserved domains on  [gi|1779478345|ref|WP_155299311|]
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UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [Deinococcus kurensis]

Protein Classification

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase( domain architecture ID 1001924)

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein

CATH:  3.90.190.20|3.40.1190.10|3.40.1390.10
EC:  6.3.2.10
Gene Ontology:  GO:0005524|GO:0009252|GO:0047480|GO:0071555
PubMed:  16934839
SCOP:  4000234

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
murF super family cl36832
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ...
 26-427 1.69e-118

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


The actual alignment was detected with superfamily member TIGR01143:

Pssm-ID: 273468 [Multi-domain]  Cd Length: 417  Bit Score: 351.95  E-value: 1.69e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345  26 WDSREAGPEVAFVALPGERTHGNAFVEQALAAGAPFVLTDLDV-----PRAVRVADAQAALFGWARAERAHAPL-VVGVT 99
Cdd:TIGR01143   1 TDSRAIKPGDLFIALKGERFDGHDFVEQALAAGAVAVVVDREVgpdngLPQILVDDTLEALQALARAKRAKFSGkVIGIT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345 100 GSAGKTTAKSYVAAALDALFMPV-----FNTMPAIACFLIESGRAGRPLVVEMGIDRVGEMAELVDLVRPDVGVITTIGP 174
Cdd:TIGR01143  81 GSSGKTTTKEMLAAILSHKYKVFatpgnFNNEIGLPLTLLRAPGDHDYAVLEMGASHPGEIAYLAEIAKPDIAVITNIGP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345 175 AHLEQLGSIEGIAREKGVILRDVAGQPVrGLVGSQAAAF--------YPGVDSYGFGDATFAGEALTVTP-GGASFRFGG 245
Cdd:TIGR01143 161 AHLEGFGSLEGIAEAKGEILQGLKENGI-AVINADDPAFadlakrlpNRNILSFGFEGGDFVAKDISYSAlGSTSFTLVA 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345 246 M----PVTLPLASTVQAEAAVLGLQLAREAGLPLPAAAARLGGVSVPGGRYRV-HPGRFTVIDDAYNASPVAVRAALDAL 320
Cdd:TIGR01143 240 PggefEVSLPLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKLVKGRFEVqTKNGLTLIDDTYNANPDSMRAALDAL 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345 321 HGWApaggGRRISVLGRMLELGPTEQALHAEVGAYARERA-DLTFGVGAFGRELGE------RTFESVPALTAALLAEVR 393
Cdd:TIGR01143 320 ARFP----GKKILVLGDMAELGEYSEELHAEVGRYANSLGiDLVFLVGEEAAVIYDsfgkqgKHFADKDELLAFLKTLVR 395

                         410       420       430
                  ....*....|....*....|....*....|....
gi 1779478345 394 DGDVVLVKASRgiswtparraqeGVGLDVVVQAL 427
Cdd:TIGR01143 396 KGDVVLVKGSR------------SVKLEKVVEAL 417
 
Name Accession Description Interval E-value
murF TIGR01143
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ...
 26-427 1.69e-118

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273468 [Multi-domain]  Cd Length: 417  Bit Score: 351.95  E-value: 1.69e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345  26 WDSREAGPEVAFVALPGERTHGNAFVEQALAAGAPFVLTDLDV-----PRAVRVADAQAALFGWARAERAHAPL-VVGVT 99
Cdd:TIGR01143   1 TDSRAIKPGDLFIALKGERFDGHDFVEQALAAGAVAVVVDREVgpdngLPQILVDDTLEALQALARAKRAKFSGkVIGIT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345 100 GSAGKTTAKSYVAAALDALFMPV-----FNTMPAIACFLIESGRAGRPLVVEMGIDRVGEMAELVDLVRPDVGVITTIGP 174
Cdd:TIGR01143  81 GSSGKTTTKEMLAAILSHKYKVFatpgnFNNEIGLPLTLLRAPGDHDYAVLEMGASHPGEIAYLAEIAKPDIAVITNIGP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345 175 AHLEQLGSIEGIAREKGVILRDVAGQPVrGLVGSQAAAF--------YPGVDSYGFGDATFAGEALTVTP-GGASFRFGG 245
Cdd:TIGR01143 161 AHLEGFGSLEGIAEAKGEILQGLKENGI-AVINADDPAFadlakrlpNRNILSFGFEGGDFVAKDISYSAlGSTSFTLVA 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345 246 M----PVTLPLASTVQAEAAVLGLQLAREAGLPLPAAAARLGGVSVPGGRYRV-HPGRFTVIDDAYNASPVAVRAALDAL 320
Cdd:TIGR01143 240 PggefEVSLPLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKLVKGRFEVqTKNGLTLIDDTYNANPDSMRAALDAL 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345 321 HGWApaggGRRISVLGRMLELGPTEQALHAEVGAYARERA-DLTFGVGAFGRELGE------RTFESVPALTAALLAEVR 393
Cdd:TIGR01143 320 ARFP----GKKILVLGDMAELGEYSEELHAEVGRYANSLGiDLVFLVGEEAAVIYDsfgkqgKHFADKDELLAFLKTLVR 395

                         410       420       430
                  ....*....|....*....|....*....|....
gi 1779478345 394 DGDVVLVKASRgiswtparraqeGVGLDVVVQAL 427
Cdd:TIGR01143 396 KGDVVLVKGSR------------SVKLEKVVEAL 417
MurF COG0770
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 14-428 2.36e-95

UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440533 [Multi-domain]  Cd Length: 451  Bit Score: 293.93  E-value: 2.36e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345  14 VHPEARAARRLTWDSREAGPEVAFVALPGERTHGNAFVEQALAAGAPFVLTDLDVP---RAVRVADAQAALFGWARAERA 90
Cdd:COG0770    17 IGDPDLVVTGVSTDSRKIKPGDLFVALKGERFDGHDFVAQALAKGAAAALVSRPLPadlPLIVVDDTLKALQQLAAAHRA 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345  91 HAPL-VVGVTGSAGKTTAKSYVAAALDALFmPVFNT----------------MPAIACFliesgragrpLVVEMGIDRVG 153
Cdd:COG0770    97 RFNIpVIAITGSNGKTTTKEMLAAVLSTKG-KVLATpgnfnneigvpltllrLPEDHEF----------AVLEMGMNHPG 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345 154 EMAELVDLVRPDVGVITTIGPAHLEQLGSIEGIAREKGVILRDVagqPVRGLvgsqaaAFYPGVD--------------- 218
Cdd:COG0770   166 EIAYLARIARPDIAVITNIGPAHLEGFGSLEGIARAKGEIFEGL---PPGGV------AVLNADDpllaalaerakarvl 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345 219 SYGFG-DATFAGEALTVTPGGASFRF----GGMPVTLPLASTVQAEAAVLGLQLAREAGLPLPAAAARLGGVSVPGGRYR 293
Cdd:COG0770   237 TFGLSeDADVRAEDIELDEDGTRFTLhtpgGELEVTLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKGRLE 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345 294 VHPGR--FTVIDDAYNASPVAVRAALDALHgwAPAGGGRRISVLGRMLELGPTEQALHAEVGAYARER-ADLTFGVGAFG 370
Cdd:COG0770   317 VIEGAggVTLIDDSYNANPDSMKAALDVLA--QLPGGGRRIAVLGDMLELGEESEELHREVGELAAELgIDRLFTVGELA 394

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1779478345 371 RELGE-------RTFESVPALTAALLAEVRDGDVVLVKASRgiswtparraqeGVGLDVVVQALL 428
Cdd:COG0770   395 RAIAEaaggeraEHFEDKEELLAALKALLRPGDVVLVKGSR------------GMGLERVVEALK 447
PRK11929 PRK11929
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ...
 18-405 2.12e-56

bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;


Pssm-ID: 237025 [Multi-domain]  Cd Length: 958  Bit Score: 200.32  E-value: 2.12e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345  18 ARAARRLTWDSREAGPEVAFVALPGERTHGNAFVEQALAAGAPFVL-----TDLDVPRAVrVADAQAALFGWARAERAH- 91
Cdd:PRK11929  523 LPHAGAVSTDSRSVGRGELFVALRGENFDGHDYLPQAFAAGACAAVverqvADVDLPQIV-VDDTRAALGRLATAWRARf 601

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345  92 APLVVGVTGSAGKTTAKSYVAAALDALFMPV--------FNT---MPAIACFLIESGRAGrplVVEMGIDRVGEMAELVD 160
Cdd:PRK11929  602 SLPVVAITGSNGKTTTKEMIAAILAAWQGEDrvlategnFNNeigVPLTLLRLRAQHRAA---VFELGMNHPGEIAYLAA 678

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345 161 LVRPDVGVITTIGPAHLEQLGSIEGIAREKGVILrdvAGQPVRGLvgsqaaAFYPGVDSY----------------GFGD 224
Cdd:PRK11929  679 IAAPTVALVTNAQREHQEFMHSVEAVARAKGEII---AALPEDGV------AVVNGDDPYtaiwaklagarrvlrfGLQP 749

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345 225 AT------FAGEALTVTPGGASFRF----GGMPVTLPLASTVQAEAAVLGLQLAREAGLPLPAAAARLGGVSVPGGRYRV 294
Cdd:PRK11929  750 GAdvyaekIAKDISVGEAGGTRCQVvtpaGSAEVYLPLIGEHNLRNALAAIACALAAGASLKQIRAGLERFQPVAGRMQR 829

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345 295 H--PGRFTVIDDAYNASPVAVRAALDALhgwAPAGGGRRISVLGRMLELGPTEQALHAEVGAYARERA-DLTFGVG---- 367
Cdd:PRK11929  830 RrlSCGTRIIDDTYNANPDSMRAAIDVL---AELPNGPRALVLGDMLELGDNGPAMHREVGKYARQLGiDALITLGeaar 906

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 1779478345 368 AFGRELGERT---FESVPALTAALLAEVRDGDVVLVKASRG 405
Cdd:PRK11929  907 DAAAAFGAGArgvCASVDEIIAALRGALPEGDSVLIKGSRF 947
Mur_ligase_M pfam08245
Mur ligase middle domain;
98-253 1.61e-17

Mur ligase middle domain;


Pssm-ID: 462409 [Multi-domain]  Cd Length: 199  Bit Score: 80.43  E-value: 1.61e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345  98 VTGSAGKTTAKSYVAAALDAL-----------FMPVFNTMPAIAC-FLIESGRAGRP--LVVEMGIDRVGEmAELVDLVR 163
Cdd:pfam08245   1 VTGTNGKTTTTELIAAILSLAggvigtigtyiGKSGNTTNNAIGLpLTLAEMVEAGAeyAVLEVSSHGLGE-GRLSGLLK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345 164 PDVGVITTIGPAHLEQLGSIEGIAREKG------------VILRDvagQPVRGLVGSQAAAFYPGVDSYGFGD-ATFAGE 230
Cdd:pfam08245  80 PDIAVFTNISPDHLDFHGTMENYAKAKAelfeglpedgiaVINAD---DPYGAFLIAKLKKAGVRVITYGIEGeADLRAA 156

                         170       180
                  ....*....|....*....|....*...
gi 1779478345 231 ALTVTPGGASFRF-----GGMPVTLPLA 253
Cdd:pfam08245 157 NIELSSDGTSFDLftvpgGELEIEIPLL 184
 
Name Accession Description Interval E-value
murF TIGR01143
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ...
 26-427 1.69e-118

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273468 [Multi-domain]  Cd Length: 417  Bit Score: 351.95  E-value: 1.69e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345  26 WDSREAGPEVAFVALPGERTHGNAFVEQALAAGAPFVLTDLDV-----PRAVRVADAQAALFGWARAERAHAPL-VVGVT 99
Cdd:TIGR01143   1 TDSRAIKPGDLFIALKGERFDGHDFVEQALAAGAVAVVVDREVgpdngLPQILVDDTLEALQALARAKRAKFSGkVIGIT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345 100 GSAGKTTAKSYVAAALDALFMPV-----FNTMPAIACFLIESGRAGRPLVVEMGIDRVGEMAELVDLVRPDVGVITTIGP 174
Cdd:TIGR01143  81 GSSGKTTTKEMLAAILSHKYKVFatpgnFNNEIGLPLTLLRAPGDHDYAVLEMGASHPGEIAYLAEIAKPDIAVITNIGP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345 175 AHLEQLGSIEGIAREKGVILRDVAGQPVrGLVGSQAAAF--------YPGVDSYGFGDATFAGEALTVTP-GGASFRFGG 245
Cdd:TIGR01143 161 AHLEGFGSLEGIAEAKGEILQGLKENGI-AVINADDPAFadlakrlpNRNILSFGFEGGDFVAKDISYSAlGSTSFTLVA 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345 246 M----PVTLPLASTVQAEAAVLGLQLAREAGLPLPAAAARLGGVSVPGGRYRV-HPGRFTVIDDAYNASPVAVRAALDAL 320
Cdd:TIGR01143 240 PggefEVSLPLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKLVKGRFEVqTKNGLTLIDDTYNANPDSMRAALDAL 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345 321 HGWApaggGRRISVLGRMLELGPTEQALHAEVGAYARERA-DLTFGVGAFGRELGE------RTFESVPALTAALLAEVR 393
Cdd:TIGR01143 320 ARFP----GKKILVLGDMAELGEYSEELHAEVGRYANSLGiDLVFLVGEEAAVIYDsfgkqgKHFADKDELLAFLKTLVR 395

                         410       420       430
                  ....*....|....*....|....*....|....
gi 1779478345 394 DGDVVLVKASRgiswtparraqeGVGLDVVVQAL 427
Cdd:TIGR01143 396 KGDVVLVKGSR------------SVKLEKVVEAL 417
MurF COG0770
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 14-428 2.36e-95

UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440533 [Multi-domain]  Cd Length: 451  Bit Score: 293.93  E-value: 2.36e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345  14 VHPEARAARRLTWDSREAGPEVAFVALPGERTHGNAFVEQALAAGAPFVLTDLDVP---RAVRVADAQAALFGWARAERA 90
Cdd:COG0770    17 IGDPDLVVTGVSTDSRKIKPGDLFVALKGERFDGHDFVAQALAKGAAAALVSRPLPadlPLIVVDDTLKALQQLAAAHRA 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345  91 HAPL-VVGVTGSAGKTTAKSYVAAALDALFmPVFNT----------------MPAIACFliesgragrpLVVEMGIDRVG 153
Cdd:COG0770    97 RFNIpVIAITGSNGKTTTKEMLAAVLSTKG-KVLATpgnfnneigvpltllrLPEDHEF----------AVLEMGMNHPG 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345 154 EMAELVDLVRPDVGVITTIGPAHLEQLGSIEGIAREKGVILRDVagqPVRGLvgsqaaAFYPGVD--------------- 218
Cdd:COG0770   166 EIAYLARIARPDIAVITNIGPAHLEGFGSLEGIARAKGEIFEGL---PPGGV------AVLNADDpllaalaerakarvl 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345 219 SYGFG-DATFAGEALTVTPGGASFRF----GGMPVTLPLASTVQAEAAVLGLQLAREAGLPLPAAAARLGGVSVPGGRYR 293
Cdd:COG0770   237 TFGLSeDADVRAEDIELDEDGTRFTLhtpgGELEVTLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKGRLE 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345 294 VHPGR--FTVIDDAYNASPVAVRAALDALHgwAPAGGGRRISVLGRMLELGPTEQALHAEVGAYARER-ADLTFGVGAFG 370
Cdd:COG0770   317 VIEGAggVTLIDDSYNANPDSMKAALDVLA--QLPGGGRRIAVLGDMLELGEESEELHREVGELAAELgIDRLFTVGELA 394

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1779478345 371 RELGE-------RTFESVPALTAALLAEVRDGDVVLVKASRgiswtparraqeGVGLDVVVQALL 428
Cdd:COG0770   395 RAIAEaaggeraEHFEDKEELLAALKALLRPGDVVLVKGSR------------GMGLERVVEALK 447
PRK11929 PRK11929
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ...
 18-405 2.12e-56

bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;


Pssm-ID: 237025 [Multi-domain]  Cd Length: 958  Bit Score: 200.32  E-value: 2.12e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345  18 ARAARRLTWDSREAGPEVAFVALPGERTHGNAFVEQALAAGAPFVL-----TDLDVPRAVrVADAQAALFGWARAERAH- 91
Cdd:PRK11929  523 LPHAGAVSTDSRSVGRGELFVALRGENFDGHDYLPQAFAAGACAAVverqvADVDLPQIV-VDDTRAALGRLATAWRARf 601

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345  92 APLVVGVTGSAGKTTAKSYVAAALDALFMPV--------FNT---MPAIACFLIESGRAGrplVVEMGIDRVGEMAELVD 160
Cdd:PRK11929  602 SLPVVAITGSNGKTTTKEMIAAILAAWQGEDrvlategnFNNeigVPLTLLRLRAQHRAA---VFELGMNHPGEIAYLAA 678

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345 161 LVRPDVGVITTIGPAHLEQLGSIEGIAREKGVILrdvAGQPVRGLvgsqaaAFYPGVDSY----------------GFGD 224
Cdd:PRK11929  679 IAAPTVALVTNAQREHQEFMHSVEAVARAKGEII---AALPEDGV------AVVNGDDPYtaiwaklagarrvlrfGLQP 749

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345 225 AT------FAGEALTVTPGGASFRF----GGMPVTLPLASTVQAEAAVLGLQLAREAGLPLPAAAARLGGVSVPGGRYRV 294
Cdd:PRK11929  750 GAdvyaekIAKDISVGEAGGTRCQVvtpaGSAEVYLPLIGEHNLRNALAAIACALAAGASLKQIRAGLERFQPVAGRMQR 829

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345 295 H--PGRFTVIDDAYNASPVAVRAALDALhgwAPAGGGRRISVLGRMLELGPTEQALHAEVGAYARERA-DLTFGVG---- 367
Cdd:PRK11929  830 RrlSCGTRIIDDTYNANPDSMRAAIDVL---AELPNGPRALVLGDMLELGDNGPAMHREVGKYARQLGiDALITLGeaar 906

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 1779478345 368 AFGRELGERT---FESVPALTAALLAEVRDGDVVLVKASRG 405
Cdd:PRK11929  907 DAAAAFGAGArgvCASVDEIIAALRGALPEGDSVLIKGSRF 947
PRK14093 PRK14093
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; ...
 18-405 3.09e-37

UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional


Pssm-ID: 184501 [Multi-domain]  Cd Length: 479  Bit Score: 141.84  E-value: 3.09e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345  18 ARAARRLTWDSREAGPEVAFVALPGERTHGNAFVEQALAAGAPFVLTD--------LDVPRAVrVADAQAALFGWARAER 89
Cdd:PRK14093   25 PRDVTGISIDSRTLAPGDAYFAIKGDVHDGHAFVAAALKAGAALAVVEraqrdkfaADAPLLV-VDDVLAALRDLGRAAR 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345  90 AHAPL-VVGVTGSAGKTTAKSYVAAALDA-----LFMPVFNTMPAIACFLIESGRAGRPLVVEMGIDRVGEMAELVDLVR 163
Cdd:PRK14093  104 ARLEAkVIAVTGSVGKTSTKEALRGVLGAqgethASVASFNNHWGVPLSLARCPADARFAVFEIGMNHAGEIEPLVKMVR 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345 164 PDVGVITTIGPAHLEQLGSIEGIAREKGVILRDV--AGQPVRGLVGSQ-----AAAFYPGVDS-YGFG-----DATFAGE 230
Cdd:PRK14093  184 PHVAIITTVEPVHLEFFSGIEAIADAKAEIFTGLepGGAAVLNRDNPQfdrlaASARAAGIARiVSFGadekaDARLLDV 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345 231 ALTVTPGGASFRFGGMPVT----LPLASTVQAEAAVLGLqlAREAGLPLPAAAARLGGVSVPGGRYRVHP-----GRFTV 301
Cdd:PRK14093  264 ALHADCSAVHADILGHDVTyklgMPGRHIAMNSLAVLAA--AELAGADLALAALALSQVQPAAGRGVRHTlevggGEATL 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345 302 IDDAYNASPVAVRAALDALHGWAPAGGGRRISVLGRMLELGPTEQALHAEV-GAYARERADLTFGVGAFGREL------G 374
Cdd:PRK14093  342 IDESYNANPASMAAALGVLGRAPVGPQGRRIAVLGDMLELGPRGPELHRGLaEAIRANAIDLVFCCGPLMRNLwdalssG 421

                         410       420       430
                  ....*....|....*....|....*....|...
gi 1779478345 375 ERT--FESVPALTAALLAEVRDGDVVLVKASRG 405
Cdd:PRK14093  422 KRGgyAEDAAALESQVVAAIRAGDVIMVKGSLG 454
murF PRK10773
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed
 25-404 6.13e-31

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed


Pssm-ID: 182718 [Multi-domain]  Cd Length: 453  Bit Score: 123.60  E-value: 6.13e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345  25 TWDSREAGPEVAFVALPGERTHGNAFVEQALAAGAPFVLT----DLDVPRAVrVADAQAA---LFGWARaERAHAPlVVG 97
Cdd:PRK10773   28 TTDTRKVTPGCLFVALKGERFDAHDFADDAKAAGAGALLVsrplDIDLPQLV-VKDTRLAfgqLAAWVR-QQVPAR-VVA 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345  98 VTGSAGKTTAKSYVAAAL----DALFMP-VFNTMPAIACFLIESGRAGRPLVVEMGIDRVGEMAELVDLVRPDVGVITTI 172
Cdd:PRK10773  105 LTGSSGKTSVKEMTAAILrqcgNTLYTAgNLNNDIGVPLTLLRLTPEHDYAVIELGANHQGEIAYTVSLTRPEAALVNNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345 173 GPAHLEQLGSIEGIAREKGVILrdvAGQPVRGLV----------------GSQAA-AFYPGvdsyGFGDATFAGEALTVT 235
Cdd:PRK10773  185 AAAHLEGFGSLAGVAKAKGEIF---SGLPENGIAimnadsndwlnwqsviGSKTVwRFSPN----AANSVDFTATNIHVT 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345 236 PGGASFR----FGGMPVTLPLASTVQAEAAVLGLQLAREAGLPLPAAAARLGGV-SVPGgryRVHPGRFT----VIDDAY 306
Cdd:PRK10773  258 SHGTEFTlhtpTGSVDVLLPLPGRHNIANALAAAALAMSVGATLDAVKAGLANLkAVPG---RLFPIQLAegqlLLDDSY 334

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345 307 NASPVAVRAALDALHGWApaggGRRISVLGRMLELGPTEQALHAEVGAYARERA-DLTFGVGAFGRELGERT-----FES 380
Cdd:PRK10773  335 NANVGSMTAAAQVLAEMP----GYRVMVVGDMAELGAESEACHRQVGEAAKAAGiDKVLSVGKLSHAISEASgvgehFAD 410

                         410       420
                  ....*....|....*....|....*.
gi 1779478345 381 VPALTAALLAEVRDGDV--VLVKASR 404
Cdd:PRK10773  411 KTALIARLKALLAEHQVitILVKGSR 436
PRK11930 PRK11930
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine ...
 27-404 1.68e-24

putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional


Pssm-ID: 237026 [Multi-domain]  Cd Length: 822  Bit Score: 106.58  E-value: 1.68e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345  27 DSRE--AGPEVAFVALPGERTHGNAFVEQALAAGAP-FVLTDLDVPRAV-------RVADAQAALFGWARAERAHAPL-V 95
Cdd:PRK11930   30 DSRSlsFPENTLFFALKGERNDGHRYIQELYEKGVRnFVVSEEKHPEESypdanflKVKDPLKALQELAAYHRSQFDIpV 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345  96 VGVTGSAGKTTAKSYvaaaLDALFMPVFNTmpaiacflIESGRA-----GRPLVV------------EMGIDRVGEMAEL 158
Cdd:PRK11930  110 IGITGSNGKTIVKEW----LYQLLSPDYNI--------VRSPRSynsqiGVPLSVwqlneehelgifEAGISQPGEMEAL 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345 159 VDLVRPDVGVITTIGPAHLEQLGSIEGIAREKGVILRDVAGQPVRG---LVGSQAAAFYPGVDSYGFG----DATFAGEA 231
Cdd:PRK11930  178 QKIIKPTIGILTNIGGAHQENFRSIKQKIMEKLKLFKDCDVIIYNGdneLISSCITKSNLTLKLISWSrkdpEAPLYIPF 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345 232 LTVTPGGA--SFRFGGMPVTLPL-----AS-----TVQAEAAVLGLQLAreaglPLPAAAARLGGVSVpggRYRVHPGRF 299
Cdd:PRK11930  258 VEKKEDHTviSYTYKGEDFHFEIpfiddASienliHCIAVLLYLGYSAD-----QIQERMARLEPVAM---RLEVKEGIN 329

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345 300 --TVIDDAYNASPVAVRAALDALHGWAPagGGRRISVLGRMLELGPTEQALHAEVGAYARERA-DLTFGVGA-------- 368
Cdd:PRK11930  330 ncTLINDSYNSDLQSLDIALDFLNRRSQ--SKKKTLILSDILQSGQSPEELYRKVAQLISKRGiDRLIGIGEeisseask 407

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1779478345 369 FgrELGERT-FESVPALTAALLAEVRDGDVVLVKASR 404
Cdd:PRK11930  408 F--EGTEKEfFKTTEAFLKSFAFLKFRNELILVKGAR 442
Mur_ligase_M pfam08245
Mur ligase middle domain;
98-253 1.61e-17

Mur ligase middle domain;


Pssm-ID: 462409 [Multi-domain]  Cd Length: 199  Bit Score: 80.43  E-value: 1.61e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345  98 VTGSAGKTTAKSYVAAALDAL-----------FMPVFNTMPAIAC-FLIESGRAGRP--LVVEMGIDRVGEmAELVDLVR 163
Cdd:pfam08245   1 VTGTNGKTTTTELIAAILSLAggvigtigtyiGKSGNTTNNAIGLpLTLAEMVEAGAeyAVLEVSSHGLGE-GRLSGLLK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345 164 PDVGVITTIGPAHLEQLGSIEGIAREKG------------VILRDvagQPVRGLVGSQAAAFYPGVDSYGFGD-ATFAGE 230
Cdd:pfam08245  80 PDIAVFTNISPDHLDFHGTMENYAKAKAelfeglpedgiaVINAD---DPYGAFLIAKLKKAGVRVITYGIEGeADLRAA 156

                         170       180
                  ....*....|....*....|....*...
gi 1779478345 231 ALTVTPGGASFRF-----GGMPVTLPLA 253
Cdd:pfam08245 157 NIELSSDGTSFDLftvpgGELEIEIPLL 184
MurE COG0769
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 24-336 3.74e-16

UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440532 [Multi-domain]  Cd Length: 459  Bit Score: 80.12  E-value: 3.74e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345  24 LTWDSREAGPEVAFVALPGERTHGNAFVEQALAAGAPFVLTDLDVPRA------VRVADAQAAL-------FGWAraerA 90
Cdd:COG0769     2 ITYDSRKVKPGDLFVALPGARVDGHDFIAQAIARGAVAVVTEAPGALLaagvpvIVVPDPRAALallaaafYGHP----S 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345  91 HAPLVVGVTGSAGKTTAKSYVAAALDAL-----------------FMPVFNTMP---AIACFLIESGRAG-RPLVVEM-- 147
Cdd:COG0769    78 QKLKLIGVTGTNGKTTTTYLLAQILRALgkktgligtvgngiggeLIPSSLTTPealDLQRLLAEMVDAGvTHVVMEVss 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345 148 -GID--RVGEmaelvdlVRPDVGVITTIGPAHLEQLGSIEGIAREK------------GVI-LRDVAGQPVrglvgsqAA 211
Cdd:COG0769   158 hALDqgRVDG-------VRFDVAVFTNLTRDHLDYHGTMEAYFAAKarlfdqlgpggaAVInADDPYGRRL-------AA 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345 212 AFYPGVDSYGF-GDATFAGEALTVTPGGASFRF----GGMPVTLPLASTVQAE--AAVLGLQLAR-EAGLPLPAAAARLG 283
Cdd:COG0769   224 AAPARVITYGLkADADLRATDIELSADGTRFTLvtpgGEVEVRLPLIGRFNVYnaLAAIAAALALgIDLEEILAALEKLK 303

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1779478345 284 GVSvpgGRY-RVHPGR-FTVIDDaYNASPVAVRAALDALHGWAPaggGRRISVLG 336
Cdd:COG0769   304 GVP---GRMeRVDGGQgPTVIVD-YAHTPDALENVLEALRPHTK---GRLIVVFG 351
murE TIGR01085
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ...
 24-363 1.98e-15

UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273435 [Multi-domain]  Cd Length: 464  Bit Score: 78.13  E-value: 1.98e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345  24 LTWDSREAGPEVAFVALPGERTHGNAFVEQALAAGAPFVLTDLDVPRAV------RVADAQAALFGWARA---ERAHAPL 94
Cdd:TIGR01085   7 LTLDSREVKPGDLFVAIKGTHVDGHDFIHDAIANGAVAVVVERDVDFYVapvpviIVPDLRHALSSLAAAfygHPSKKLK 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345  95 VVGVTGSAGKTTAKSYVAAALDAL-----FM---------------PVFNTMPA---IACFLIESGRAGRPLVVeMGIDR 151
Cdd:TIGR01085  87 VIGVTGTNGKTTTTSLIAQLLRLLgkktgLIgtigyrlggndliknPAALTTPEaltLQSTLAEMVEAGAQYAV-MEVSS 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345 152 VGEMAELVDLVRPDVGVITTIGPAHLEQLGSIE-------------GIAREKGVILRDVAGQPVRGlvGSQAAAFYPGVD 218
Cdd:TIGR01085 166 HALAQGRVRGVRFDAAVFTNLSRDHLDFHGTMEnyfaakaslftelGLKRFAVINLDDEYGAQFVK--RLPKDITVSAIT 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345 219 SYGFGDATFAGE-ALTVTPGGASFRF----GGMPVTLPL-----ASTVQAEAAVLGLQLAREAGLPLPAAAARLGgvsVP 288
Cdd:TIGR01085 244 QPADGRAQDIKItDSGYSFEGQQFTFetpaGEGHLHTPLigrfnVYNLLAALATLLHLGGIDLEDIVAALEKFRG---VP 320

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1779478345 289 GGRYRVHPG-RFTVIDDaYNASPVAVRAALDALhgwAPAGGGRRISVLGRMLELGPTEQALHAEVGAYARERADLT 363
Cdd:TIGR01085 321 GRMELVDGGqKFLVIVD-YAHTPDALEKALRTL---RKHKDGRLIVVFGCGGDRDRGKRPLMGAIAEQLADLVILT 392
murE PRK00139
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
 18-336 4.82e-15

UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional


Pssm-ID: 234660 [Multi-domain]  Cd Length: 460  Bit Score: 76.71  E-value: 4.82e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345  18 ARAARRLTWDSREAGPEVAFVALPGERTHGNAFVEQALAAGAPFVLTD------LDVPrAVRVADAQAALfGWARAERAH 91
Cdd:PRK00139   12 PVEITGLTYDSRKVKPGDLFVALPGHKVDGRDFIAQAIANGAAAVVAEadgeagTGVP-VIIVPDLRKAL-ALLAAAFYG 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345  92 AP----LVVGVTGSAGKTTAKSYVAAALDALFMP--VFNTmpaiacflIESGRAGRPLVVEM----GIDRVGEMAELVDL 161
Cdd:PRK00139   90 HPsdklKLIGVTGTNGKTTTAYLLAQILRLLGEKtaLIGT--------LGNGIGGELIPSGLttpdALDLQRLLAELVDA 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345 162 ---------------------VRPDVGVITTIGPAHLEQLGSIEGIAREKGVILRDVAGQPVRGLVGSQAAAFYPGVDSY 220
Cdd:PRK00139  162 gvtyaamevsshaldqgrvdgLKFDVAVFTNLSRDHLDYHGTMEDYLAAKARLFSELGLAAVINADDEVGRRLLALPDAY 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345 221 GFG--DATFAGEALTVTPGGASFRFGGmPVTLPLASTVQAE---AAVLGLQLAREAGLPLPAAAARLGGVSvpgGRY-RV 294
Cdd:PRK00139  242 AVSmaGADLRATDVEYTDSGQTFTLVT-EVESPLIGRFNVSnllAALAALLALGVPLEDALAALAKLQGVP---GRMeRV 317

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1779478345 295 H-PGRFTVI-DDAYNasPVAVRAALDALHgwaPAGGGRRISVLG 336
Cdd:PRK00139  318 DaGQGPLVIvDYAHT--PDALEKVLEALR---PHAKGRLICVFG 356
PRK11929 PRK11929
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ...
 12-122 1.36e-12

bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;


Pssm-ID: 237025 [Multi-domain]  Cd Length: 958  Bit Score: 69.73  E-value: 1.36e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345  12 AAVHPEARAARRLTWDSREAGPEVAFVALPGERTHGNAFVEQALAAGAPFVLTDLDV--------PRAVRVADAQAALFG 83
Cdd:PRK11929   20 AWLRGCVAATADLRLDSREVQPGDLFVACRGAASDGRAFIDQALARGAAAVLVEAEGedqvaaadALVLPVADLRKALGE 99

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1779478345  84 WARAERAHAP---LVVGVTGSAGKTTAKSYVAAALDALFMPV 122
Cdd:PRK11929  100 LAARWYGRPSeqlSLVAVTGTNGKTSCAQLLAQLLTRLGKPC 141
murD TIGR01087
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ...
 51-184 5.33e-06

UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273436 [Multi-domain]  Cd Length: 433  Bit Score: 48.49  E-value: 5.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345  51 VEQALAAGAPfVLTDLDVpravrvadaqaalfgwarAERAHAPLVVGVTGSAGKTTAKSYVAAALDALFMPVFntmpaia 130
Cdd:TIGR01087  79 VQAAAKRGIP-VVGDIEL------------------FLRLVPLPVVAITGTNGKTTTTSLLYHLLKAAGLKAF------- 132

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1779478345 131 cfliESGRAGRPLVVEMGIDRVG----EMA----ELVDLVRPDVGVITTIGPAHLEQLGSIE 184
Cdd:TIGR01087 133 ----LGGNIGTPALEVLDQEGAElyvlELSsfqlETTESLRPEIALILNISEDHLDWHGSFE 190
Mur_ligase_C pfam02875
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ...
 297-371 2.90e-05

Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.


Pssm-ID: 460731 [Multi-domain]  Cd Length: 87  Bit Score: 42.33  E-value: 2.90e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1779478345 297 GRFTVIDDaYNASPVAVRAALDALHGWAPaggGRRISVLGRMLELGPTeqaLHAEVGAYARERADLTFGVGAFGR 371
Cdd:pfam02875  12 NGVLVIDD-YAHNPDAMEAALRALRNLFP---GRLILVFGGMGDRDAE---FHALLGRLAAALADVVILTGDYPR 79
MurD COG0771
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ...
 48-195 5.53e-05

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440534 [Multi-domain]  Cd Length: 445  Bit Score: 45.07  E-value: 5.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345  48 NAFVEQALAAGAPfVLTDLDVprAVRVADAQaalfgwaraerahaplVVGVTGSAGKTTAKSYVAAALDALFMPVF---N 124
Cdd:COG0771    79 HPLLKAARAAGIP-VIGEIEL--AYRLSPAP----------------IIAITGTNGKTTTTTLIGHILKAAGLRVAvggN 139

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1779478345 125 -TMPAIAcfLIESGRAGRPLVVE------MGIDRVgemaelvdlvRPDVGVITTIGPAHLEQLGSIEGIAREKGVILR 195
Cdd:COG0771   140 iGTPLLD--LLLEPEPPDVYVLElssfqlETTPSL----------RPDVAVILNITPDHLDRHGSMEAYAAAKARIFA 205
Mur_ligase pfam01225
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes ...
 27-65 8.78e-04

Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.


Pssm-ID: 460121 [Multi-domain]  Cd Length: 84  Bit Score: 37.98  E-value: 8.78e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1779478345  27 DSREAGPEVAFVALPGERTHGNAFVEQALAAGAPFVLTD 65
Cdd:pfam01225   8 DGRGMSPGALFLALKGYRVDGSDFIESLIALGAAAVVGH 46
PRK14022 PRK14022
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;
23-126 6.60e-03

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;


Pssm-ID: 237588 [Multi-domain]  Cd Length: 481  Bit Score: 38.86  E-value: 6.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1779478345  23 RLTWDSREAGPEVAFVALPGERTHgnAFVEQALAAGAPFVLTD----LDVPrAVRVADA-QAA------LFGWARaeraH 91
Cdd:PRK14022   36 DISYDSRTADEGTLFFAKGAYFKH--KFLQNAITQGLKLYVSEkdyeVGIP-QVIVPDIkKAMsliameFYDNPQ----H 108

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1779478345  92 APLVVGVTGSAGKTTAKSYVAAALDALFMP-VFNTM 126
Cdd:PRK14022  109 KLKLLAFTGTKGKTTAAYFAYHILKQLHKPaMLSTM 144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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