|
Name |
Accession |
Description |
Interval |
E-value |
| MenE/FadK |
COG0318 |
O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) [Lipid ... |
30-556 |
4.59e-180 |
|
O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]; O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) is part of the Pathway/BioSystem: Menaquinone biosynthesis
Pssm-ID: 440087 [Multi-domain] Cd Length: 452 Bit Score: 514.74 E-value: 4.59e-180
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 30 DMFAAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPM 109
Cdd:COG0318 3 DLLRRAAARHPDRPALVFGGRRLTYAELDARARRLAAALRALGVGPGDRVALLLPNSPEFVVAFLAALRAGAVVVPLNPR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 110 NRARELKLLLDDSQARVLICdaalegevvreviasieaegnaaprvfttraralqtrddprvfgtqreasgagegardll 189
Cdd:COG0318 83 LTAEELAYILEDSGARALVT------------------------------------------------------------ 102
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 190 qaaqavqpgrkpppvvlaasdpAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLVGHI 269
Cdd:COG0318 103 ----------------------ALILYTSGTTGRPKGVMLTHRNLLANAAAIAAALGLTPGDVVLVALPLFHVFGLTVGL 160
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 270 GAAWIARAPLILTHRFDPAATLDAIEEHRAEFTIGAITVFIALLHHADATREKLATLTKIYSGGAPIAPSVVEAFRAKFG 349
Cdd:COG0318 161 LAPLLAGATLVLLPRFDPERVLELIERERVTVLFGVPTMLARLLRHPEFARYDLSSLRLVVSGGAPLPPELLERFEERFG 240
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 350 HVIHGAYGLTETNSPTHMVPlARTAPVDPHSgalaMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWNNAAA 429
Cdd:COG0318 241 VRIVEGYGLTETSPVVTVNP-EDPGERRPGS----VGRPLPGVEVRIVDEDGRELPPGEVGEIVVRGPNVMKGYWNDPEA 315
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 430 TADAFRGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLR 509
Cdd:COG0318 316 TAEAFRDGWLRTGDLGRLDEDGYLYIVGRKKDMIISGGENVYPAEVEEVLAAHPGVAEAAVVGVPDEKWGERVVAFVVLR 395
|
490 500 510 520
....*....|....*....|....*....|....*....|....*..
gi 1595048490 510 AGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:COG0318 396 PGAELDAEELRAFLRERLARYKVPRRVEFVDELPRTASGKIDRRALR 442
|
|
| FC-FACS_FadD_like |
cd05936 |
Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; This ... |
29-556 |
2.82e-177 |
|
Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; This subfamily of the AMP-forming adenylation family contains Escherichia coli FadD and similar prokaryotic fatty acid CoA synthetases. FadD was characterized as a long-chain fatty acid CoA synthetase. The gene fadD is regulated by the fatty acid regulatory protein FadR. Fatty acid CoA synthetase catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, followed by the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341259 [Multi-domain] Cd Length: 468 Bit Score: 508.26 E-value: 2.82e-177
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 29 LDMFAAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNP 108
Cdd:cd05936 2 ADLLEEAARRFPDKTALIFMGRKLTYRELDALAEAFAAGLQNLGVQPGDRVALMLPNCPQFPIAYFGALKAGAVVVPLNP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 109 MNRARELKLLLDDSQARVLICDAALEgevvreviasieaegnaaprvfttraralqtrddprvfgtqreasgagegarDL 188
Cdd:cd05936 82 LYTPRELEHILNDSGAKALIVAVSFT----------------------------------------------------DL 109
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 189 LQAaqavqPGRKPPPVVLAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGP--ILGVAPLFHITGLV 266
Cdd:cd05936 110 LAA-----GAPLGERVALTPEDVAVLQYTSGTTGVPKGAMLTHRNLVANALQIKAWLEDLLEGDdvVLAALPLFHVFGLT 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 267 GHIGAAWIARAPLILTHRFDPAATLDAIEEHRAEFTIGAITVFIALLHHADATREKLATLTKIYSGGAPIAPSVVEAFRA 346
Cdd:cd05936 185 VALLLPLALGATIVLIPRFRPIGVLKEIRKHRVTIFPGVPTMYIALLNAPEFKKRDFSSLRLCISGGAPLPVEVAERFEE 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 347 KFGHVIHGAYGLTETNSPTHMVPLARtapvDPHSGALamGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWNN 426
Cdd:cd05936 265 LTGVPIVEGYGLTETSPVVAVNPLDG----PRKPGSI--GIPLPGTEVKIVDDDGEELPPGEVGELWVRGPQVMKGYWNR 338
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 427 AAATADAFRGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVV 506
Cdd:cd05936 339 PEETAEAFVDGWLRTGDIGYMDEDGYFFIVDRKKDMIIVGGFNVYPREVEEVLYEHPAVAEAAVVGVPDPYSGEAVKAFV 418
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|
gi 1595048490 507 SLRAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:cd05936 419 VLKEGASLTEEEIIAFCREQLAGYKVPRQVEFRDELPKSAVGKILRRELR 468
|
|
| PRK08314 |
PRK08314 |
long-chain-fatty-acid--CoA ligase; Validated |
33-555 |
1.04e-151 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 236235 [Multi-domain] Cd Length: 546 Bit Score: 445.94 E-value: 1.04e-151
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 33 AAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDE-GVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNR 111
Cdd:PRK08314 17 EVSARRYPDKTAIVFYGRAISYRELLEEAERLAGYLQQEcGVRKGDRVLLYMQNSPQFVIAYYAILRANAVVVPVNPMNR 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 112 ARELKLLLDDSQARVLICDAALEGEV--------VREVIAS-----IEAEGNAAPRVFTTRARALQTRDDPRVfgtqrea 178
Cdd:PRK08314 97 EEELAHYVTDSGARVAIVGSELAPKVapavgnlrLRHVIVAqysdyLPAEPEIAVPAWLRAEPPLQALAPGGV------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 179 sgagegardlLQAAQAVQPGRKPPPVVLAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAP 258
Cdd:PRK08314 170 ----------VAWKEALAAGLAPPPHTAGPDDLAVLPYTSGTTGVPKGCMHTHRTVMANAVGSVLWSNSTPESVVLAVLP 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 259 LFHITGLVGHIGAAWIARAPLILTHRFDPAATLDAIEEHRAEFTIGAITVFIALLHHADATREKLATLTKIYSGGAPIAP 338
Cdd:PRK08314 240 LFHVTGMVHSMNAPIYAGATVVLMPRWDREAAARLIERYRVTHWTNIPTMVVDFLASPGLAERDLSSLRYIGGGGAAMPE 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 339 SVVEAFRAKFGHVIHGAYGLTETNSPTHMVPLARtapvdPHSGALamGVPVPGAEAAIVD-DDGNMLAAGETGEIVCRGP 417
Cdd:PRK08314 320 AVAERLKELTGLDYVEGYGLTETMAQTHSNPPDR-----PKLQCL--GIPTFGVDARVIDpETLEELPPGEVGEIVVHGP 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 418 MVVPGYWNNAAATADAF--RGG--WFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGV 493
Cdd:PRK08314 393 QVFKGYWNRPEATAEAFieIDGkrFFRTGDLGRMDEEGYFFITDRLKRMINASGFKVWPAEVENLLYKHPAIQEACVIAT 472
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1595048490 494 PDPYRGETVKAVVSLRAGAVA--DAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRREL 555
Cdd:PRK08314 473 PDPRRGETVKAVVVLRPEARGktTEEEIIAWAREHMAAYKYPRIVEFVDSLPKSGSGKILWRQL 536
|
|
| FACL_FadD13-like |
cd17631 |
fatty acyl-CoA synthetase, including FadD13; This family contains fatty acyl-CoA synthetases, ... |
35-552 |
7.95e-149 |
|
fatty acyl-CoA synthetase, including FadD13; This family contains fatty acyl-CoA synthetases, including Mycobacterium tuberculosis acid-induced operon MymA encoding the fatty acyl-CoA synthetase FadD13 which is essential for virulence and intracellular growth of the pathogen. The fatty acyl-CoA synthetase activates lipids before entering into the metabolic pathways and is also involved in transmembrane lipid transport. However, unlike soluble fatty acyl-CoA synthetases, but like the mammalian integral-membrane very-long-chain acyl-CoA synthetases, FadD13 accepts lipid substrates up to the maximum length of C26, and this is facilitated by an extensive hydrophobic tunnel from the active site to a positively charged patch. Also included is feruloyl-CoA synthetase (Fcs) in Rhodococcus strains where it is involved in biotechnological vanillin production from eugenol and ferulic acid via a non-beta-oxidative pathway.
Pssm-ID: 341286 [Multi-domain] Cd Length: 435 Bit Score: 434.73 E-value: 7.95e-149
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 35 ALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARE 114
Cdd:cd17631 4 RARRHPDRTALVFGGRSLTYAELDERVNRLAHALRALGVAKGDRVAVLSKNSPEFLELLFAAARLGAVFVPLNFRLTPPE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 115 LKLLLDDSQARVLIcdaalegevvreviasieaegnaaprvfttraralqtrddprvfgtqreasgagegardllqaaqa 194
Cdd:cd17631 84 VAYILADSGAKVLF------------------------------------------------------------------ 97
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 195 vqpgrkpppvvlaaSDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLVGHIGAAWI 274
Cdd:cd17631 98 --------------DDLALLMYTSGTTGRPKGAMLTHRNLLWNAVNALAALDLGPDDVLLVVAPLFHIGGLGVFTLPTLL 163
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 275 ARAPLILTHRFDPAATLDAIEEHRAEFTIGAITVFIALLHHADATREKLATLTKIYSGGAPIAPSVVEAFRAkFGHVIHG 354
Cdd:cd17631 164 RGGTVVILRKFDPETVLDLIERHRVTSFFLVPTMIQALLQHPRFATTDLSSLRAVIYGGAPMPERLLRALQA-RGVKFVQ 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 355 AYGLTETnspthmVPLARTAPVDPHSG-ALAMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWNNAAATADA 433
Cdd:cd17631 243 GYGMTET------SPGVTFLSPEDHRRkLGSAGRPVFFVEVRIVDPDGREVPPGEVGEIVVRGPHVMAGYWNRPEATAAA 316
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 434 FRGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAV 513
Cdd:cd17631 317 FRDGWFHTGDLGRLDEDGYLYIVDRKKDMIISGGENVYPAEVEDVLYEHPAVAEVAVIGVPDEKWGEAVVAVVVPRPGAE 396
|
490 500 510
....*....|....*....|....*....|....*....
gi 1595048490 514 ADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILR 552
Cdd:cd17631 397 LDEDELIAHCRERLARYKIPKSVEFVDALPRNATGKILK 435
|
|
| PRK06187 |
PRK06187 |
long-chain-fatty-acid--CoA ligase; Validated |
22-556 |
2.99e-141 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 235730 [Multi-domain] Cd Length: 521 Bit Score: 418.44 E-value: 2.99e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 22 QQEYTNGLDMFAAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGA 101
Cdd:PRK06187 2 QDYPLTIGRILRHGARKHPDKEAVYFDGRRTTYAELDERVNRLANALRALGVKKGDRVAVFDWNSHEYLEAYFAVPKIGA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 102 VMVPVNPMNRARELKLLLDDSQARVLICDAALEGEVVReviasieaegnAAPRvFTTRARALQTRDDPRVfgtqrEASGA 181
Cdd:PRK06187 82 VLHPINIRLKPEEIAYILNDAEDRVVLVDSEFVPLLAA-----------ILPQ-LPTVRTVIVEGDGPAA-----PLAPE 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 182 GEGARDLLQAaqavQPGRKPPPVVlAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFH 261
Cdd:PRK06187 145 VGEYEELLAA----ASDTFDFPDI-DENDAAAMLYTSGTTGHPKGVVLSHRNLFLHSLAVCAWLKLSRDDVYLVIVPMFH 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 262 ITGLvgHIG-AAWIARAPLILTHRFDPAATLDAIEEHRAEFTIGAITVFIALLHHADATREKLATLTKIYSGGAPIAPSV 340
Cdd:PRK06187 220 VHAW--GLPyLALMAGAKQVIPRRFDPENLLDLIETERVTFFFAVPTIWQMLLKAPRAYFVDFSSLRLVIYGGAALPPAL 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 341 VEAFRAKFGHVIHGAYGLTETNspthmvPLARTAPVDPHSGA-----LAMGVPVPGAEAAIVDDDGNMLAA--GETGEIV 413
Cdd:PRK06187 298 LREFKEKFGIDLVQGYGMTETS------PVVSVLPPEDQLPGqwtkrRSAGRPLPGVEARIVDDDGDELPPdgGEVGEII 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 414 CRGPMVVPGYWNNAAATADAFRGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGV 493
Cdd:PRK06187 372 VRGPWLMQGYWNRPEATAETIDGGWLHTGDVGYIDEDGYLYITDRIKDVIISGGENIYPRELEDALYGHPAVAEVAVIGV 451
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1595048490 494 PDPYRGETVKAVVSLRAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:PRK06187 452 PDEKWGERPVAVVVLKPGATLDAKELRAFLRGRLAKFKLPKRIAFVDELPRTSVGKILKRVLR 514
|
|
| PRK07656 |
PRK07656 |
long-chain-fatty-acid--CoA ligase; Validated |
30-556 |
8.66e-140 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 236072 [Multi-domain] Cd Length: 513 Bit Score: 414.30 E-value: 8.66e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 30 DMFAAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPM 109
Cdd:PRK07656 9 ELLARAARRFGDKEAYVFGDQRLTYAELNARVRRAAAALAALGIGKGDRVAIWAPNSPHWVIAALGALKAGAVVVPLNTR 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 110 NRARELKLLLDDSQARVLICDAALEGE---------VVREVIASIEAEGNAAPRVFTTRARALQTrddprvfGTQREASG 180
Cdd:PRK07656 89 YTADEAAYILARGDAKALFVLGLFLGVdysattrlpALEHVVICETEEDDPHTEKMKTFTDFLAA-------GDPAERAP 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 181 AgegardllqaaqavqpgrkpppvvLAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLF 260
Cdd:PRK07656 162 E------------------------VDPDDVADILFTSGTTGRPKGAMLTHRQLLSNAADWAEYLGLTEGDRYLAANPFF 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 261 HITGLVGHIGAAWIARAPLILTHRFDPAATLDAIEEHRAEFTIGAITVFIALLHHADATREKLATLTKIYSGGAPIAPSV 340
Cdd:PRK07656 218 HVFGYKAGVNAPLMRGATILPLPVFDPDEVFRLIETERITVLPGPPTMYNSLLQHPDRSAEDLSSLRLAVTGAASMPVAL 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 341 VEAFRAKFG-HVIHGAYGLTETNSPTHMVPLARTAPVDPHSgalaMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMV 419
Cdd:PRK07656 298 LERFESELGvDIVLTGYGLSEASGVTTFNRLDDDRKTVAGT----IGTAIAGVENKIVNELGEEVPVGEVGELLVRGPNV 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 420 VPGYWNNAAATADAFRG-GWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYR 498
Cdd:PRK07656 374 MKGYYDDPEATAAAIDAdGWLHTGDLGRLDEEGYLYIVDRKKDMFIVGGFNVYPAEVEEVLYEHPAVAEAAVIGVPDERL 453
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*...
gi 1595048490 499 GETVKAVVSLRAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:PRK07656 454 GEVGKAYVVLKPGAELTEEELIAYCREHLAKYKVPRSIEFLDELPKNATGKVLKRALR 511
|
|
| AFD_class_I |
cd04433 |
Adenylate forming domain, Class I, also known as the ANL superfamily; This family is known as ... |
210-551 |
1.17e-134 |
|
Adenylate forming domain, Class I, also known as the ANL superfamily; This family is known as the ANL (acyl-CoA synthetases, the NRPS adenylation domains, and the Luciferase enzymes) superfamily. It includes acyl- and aryl-CoA ligases, as well as the adenylation domain of nonribosomal peptide synthetases and firefly luciferases.The adenylate-forming enzymes catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain.
Pssm-ID: 341228 [Multi-domain] Cd Length: 336 Bit Score: 394.73 E-value: 1.17e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 210 DPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHItGLVGHIGAAWIARAPLILTHRFDPAA 289
Cdd:cd04433 1 DPALILYTSGTTGKPKGVVLSHRNLLAAAAALAASGGLTEGDVFLSTLPLFHI-GGLFGLLGALLAGGTVVLLPKFDPEA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 290 TLDAIEEHRAEFTIGAITVFIALLHHADATREKLATLTKIYSGGAPIAPSVVEAFRAKFGHVIHGAYGLTETNSPThmvp 369
Cdd:cd04433 80 ALELIEREKVTILLGVPTLLARLLKAPESAGYDLSSLRALVSGGAPLPPELLERFEEAPGIKLVNGYGLTETGGTV---- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 370 lARTAPVDPHSGALAMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWNNAAATADAFRGGWFHTGDVGFMDE 449
Cdd:cd04433 156 -ATGPPDDDARKPGSVGRPVPGVEVRIVDPDGGELPPGEIGELVVRGPSVMKGYWNNPEATAAVDEDGWYRTGDLGRLDE 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 450 AGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVADAAELIAFCKARMAA 529
Cdd:cd04433 235 DGYLYIVGRLKDMIKSGGENVYPAEVEAVLLGHPGVAEAAVVGVPDPEWGERVVAVVVLRPGADLDAEELRAHVRERLAP 314
|
330 340
....*....|....*....|..
gi 1595048490 530 YKYPRIVEFRDELPKTATGKIL 551
Cdd:cd04433 315 YKVPRRVVFVDALPRTASGKID 336
|
|
| Firefly_Luc_like |
cd05911 |
Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL); This family ... |
59-551 |
2.23e-134 |
|
Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL); This family contains insect firefly luciferases that share significant sequence similarity to plant 4-coumarate:coenzyme A ligases, despite their functional diversity. Luciferase catalyzes the production of light in the presence of MgATP, molecular oxygen, and luciferin. In the first step, luciferin is activated by acylation of its carboxylate group with ATP, resulting in an enzyme-bound luciferyl adenylate. In the second step, luciferyl adenylate reacts with molecular oxygen, producing an enzyme-bound excited state product (Luc=O*) and releasing AMP. This excited-state product then decays to the ground state (Luc=O), emitting a quantum of visible light.
Pssm-ID: 341237 [Multi-domain] Cd Length: 486 Bit Score: 399.67 E-value: 2.23e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 59 AWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLICDAAlegevV 138
Cdd:cd05911 18 TLSRRLAAGLRKLGLKKGDVVGIISPNSTYYPPVFLGCLFAGGIFSAANPIYTADELAHQLKISKPKVIFTDPD-----G 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 139 REVIASIEAEGNAAPRVFTTRaralqTRDDPRVFGTQREASGAGEGARDLlqaaqavqpgrkPPPVVLAASDPAMLVYTS 218
Cdd:cd05911 93 LEKVKEAAKELGPKDKIIVLD-----DKPDGVLSIEDLLSPTLGEEDEDL------------PPPLKDGKDDTAAILYSS 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 219 GTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGP--ILGVAPLFHITGLVGHIGAAWiARAPLILTHRFDPAATLDAIEE 296
Cdd:cd05911 156 GTTGLPKGVCLSHRNLIANLSQVQTFLYGNDGSNdvILGFLPLYHIYGLFTTLASLL-NGATVIIMPKFDSELFLDLIEK 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 297 HRAEFTIGAITVFIALLHHADATREKLATLTKIYSGGAPIAPSVVEAFRAKFGHV-IHGAYGLTETNSPTHMVPLArtap 375
Cdd:cd05911 235 YKITFLYLVPPIAAALAKSPLLDKYDLSSLRVILSGGAPLSKELQELLAKRFPNAtIKQGYGMTETGGILTVNPDG---- 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 376 vDPHSGALamGVPVPGAEAAIVDDDGN-MLAAGETGEIVCRGPMVVPGYWNNAAATADAF-RGGWFHTGDVGFMDEAGWF 453
Cdd:cd05911 311 -DDKPGSV--GRLLPNVEAKIVDDDGKdSLGPNEPGEICVRGPQVMKGYYNNPEATKETFdEDGWLHTGDIGYFDEDGYL 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 454 YLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVADAAELIAFCKARMAAYKyp 533
Cdd:cd05911 388 YIVDRKKELIKYKGFQVAPAELEAVLLEHPGVADAAVIGIPDEVSGELPRAYVVRKPGEKLTEKEVKDYVAKKVASYK-- 465
|
490 500
....*....|....*....|.
gi 1595048490 534 RI---VEFRDELPKTATGKIL 551
Cdd:cd05911 466 QLrggVVFVDEIPKSASGKIL 486
|
|
| Acs |
COG0365 |
Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism]; |
46-556 |
3.12e-132 |
|
Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism];
Pssm-ID: 440134 [Multi-domain] Cd Length: 565 Bit Score: 396.79 E-value: 3.12e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 46 LYFDG------RLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLL 119
Cdd:COG0365 28 LIWEGedgeerTLTYAELRREVNRFANALRALGVKKGDRVAIYLPNIPEAVIAMLACARIGAVHSPVFPGFGAEALADRI 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 120 DDSQARVLIC-DAALEGEVVREVIASIEAEGNAAPRVfttraralqtrddPRVFGTQREASGAG-EGARDLLQAAQAVqp 197
Cdd:COG0365 108 EDAEAKVLITaDGGLRGGKVIDLKEKVDEALEELPSL-------------EHVIVVGRTGADVPmEGDLDWDELLAAA-- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 198 GRKPPPVVLAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTY-RDFCGLREGGPILGVAPLFHITGLVGHIGAAWIAR 276
Cdd:COG0365 173 SAEFEPEPTDADDPLFILYTSGTTGKPKGVVHTHGGYLVHAATTaKYVLDLKPGDVFWCTADIGWATGHSYIVYGPLLNG 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 277 APLIL---THRF-DPAATLDAIEEHRAEFTIGAITVFIALLHHADATREK--LATLTKIYSGGAPIAPSVVEAFRAKFGH 350
Cdd:COG0365 253 ATVVLyegRPDFpDPGRLWELIEKYGVTVFFTAPTAIRALMKAGDEPLKKydLSSLRLLGSAGEPLNPEVWEWWYEAVGV 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 351 VIHGAYGLTETNSptHMVPLARTAPVDPHSgalaMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVV--PGYWNNAA 428
Cdd:COG0365 333 PIVDGWGQTETGG--IFISNLPGLPVKPGS----MGKPVPGYDVAVVDEDGNPVPPGEEGELVIKGPWPGmfRGYWNDPE 406
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 429 ATADAFRG---GWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAV 505
Cdd:COG0365 407 RYRETYFGrfpGWYRTGDGARRDEDGYFWILGRSDDVINVSGHRIGTAEIESALVSHPAVAEAAVVGVPDEIRGQVVKAF 486
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 1595048490 506 VSLRAGAVAD---AAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:COG0365 487 VVLKPGVEPSdelAKELQAHVREELGPYAYPREIEFVDELPKTRSGKIMRRLLR 540
|
|
| PRK08316 |
PRK08316 |
acyl-CoA synthetase; Validated |
30-556 |
5.62e-132 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 181381 [Multi-domain] Cd Length: 523 Bit Score: 394.68 E-value: 5.62e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 30 DMFAAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPM 109
Cdd:PRK08316 15 DILRRSARRYPDKTALVFGDRSWTYAELDAAVNRVAAALLDLGLKKGDRVAALGHNSDAYALLWLACARAGAVHVPVNFM 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 110 NRARELKLLLDDSQARVLICDAALeGEVVREVIASieaegnaAPRVFTTRARALQTRDDPrvfgtqreasgagEGARDLL 189
Cdd:PRK08316 95 LTGEELAYILDHSGARAFLVDPAL-APTAEAALAL-------LPVDTLILSLVLGGREAP-------------GGWLDFA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 190 QAAQAvqPGRKPPPVVLAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLVGHI 269
Cdd:PRK08316 154 DWAEA--GSVAEPDVELADDDLAQILYTSGTESLPKGAMLTHRALIAEYVSCIVAGDMSADDIPLHALPLYHCAQLDVFL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 270 GAAWIARAPLILTHRFDPAATLDAIEEHRAEFTIGAITVFIALLHHADATREKLATLTKIYSGGAPIAPSVVEAFRAKFG 349
Cdd:PRK08316 232 GPYLYVGATNVILDAPDPELILRTIEAERITSFFAPPTVWISLLRHPDFDTRDLSSLRKGYYGASIMPVEVLKELRERLP 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 350 HV-IHGAYGLTEtnspthMVPLARTAPVDPHSGALA-MGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWNNA 427
Cdd:PRK08316 312 GLrFYNCYGQTE------IAPLATVLGPEEHLRRPGsAGRPVLNVETRVVDDDGNDVAPGEVGEIVHRSPQLMLGYWDDP 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 428 AATADAFRGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVS 507
Cdd:PRK08316 386 EKTAEAFRGGWFHSGDLGVMDEEGYITVVDRKKDMIKTGGENVASREVEEALYTHPAVAEVAVIGLPDPKWIEAVTAVVV 465
|
490 500 510 520
....*....|....*....|....*....|....*....|....*....
gi 1595048490 508 LRAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:PRK08316 466 PKAGATVTEDELIAHCRARLAGFKVPKRVIFVDELPRNPSGKILKRELR 514
|
|
| LC_FACS_like |
cd05935 |
Putative long-chain fatty acid CoA ligase; The members of this family are putative long-chain ... |
62-555 |
6.74e-122 |
|
Putative long-chain fatty acid CoA ligase; The members of this family are putative long-chain fatty acyl-CoA synthetases, which catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. Fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters.
Pssm-ID: 341258 [Multi-domain] Cd Length: 430 Bit Score: 365.65 E-value: 6.74e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 62 DRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLICDAALEgevvrev 141
Cdd:cd05935 12 KKLASFLSNKGVRKGDRVGICLQNSPQYVIAYFAIWRANAVVVPINPMLKERELEYILNDSGAKVAVVGSELD------- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 142 iasieaegnaaprvfttraralqtrddprvfgtqreasgagegardllqaaqavqpgrkpppvvlaasDPAMLVYTSGTS 221
Cdd:cd05935 85 --------------------------------------------------------------------DLALIPYTSGTT 96
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 222 GRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLVGHIGAAWIARAPLILTHRFDPAATLDAIEEHRAEF 301
Cdd:cd05935 97 GLPKGCMHTHFSAAANALQSAVWTGLTPSDVILACLPLFHVTGFVGSLNTAVYVGGTYVLMARWDRETALELIEKYKVTF 176
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 302 TIGAITVFIALLHHADATREKLATLTKIYSGGAPIAPSVVEAFRAKFGHVIHGAYGLTETNSPTHMVPLARtapvdPHSG 381
Cdd:cd05935 177 WTNIPTMLVDLLATPEFKTRDLSSLKVLTGGGAPMPPAVAEKLLKLTGLRFVEGYGLTETMSQTHTNPPLR-----PKLQ 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 382 ALamGVPVPGAEAAIVD-DDGNMLAAGETGEIVCRGPMVVPGYWNNAAATADAF--RGG--WFHTGDVGFMDEAGWFYLV 456
Cdd:cd05935 252 CL--GIP*FGVDARVIDiETGRELPPNEVGEIVVRGPQIFKGYWNRPEETEESFieIKGrrFFRTGDLGYMDEEGYFFFV 329
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 457 DRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAG--AVADAAELIAFCKARMAAYKYPR 534
Cdd:cd05935 330 DRVKRMINVSGFKVWPAEVEAKLYKHPAI*EVCVISVPDERVGEEVKAFIVLRPEyrGKVTEEDIIEWAREQMAAYKYPR 409
|
490 500
....*....|....*....|.
gi 1595048490 535 IVEFRDELPKTATGKILRREL 555
Cdd:cd05935 410 EVEFVDELPRSASGKILWRLL 430
|
|
| FACL_DitJ_like |
cd05934 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ... |
49-556 |
2.19e-117 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Members of this family include DitJ from Pseudomonas and similar proteins.
Pssm-ID: 341257 [Multi-domain] Cd Length: 422 Bit Score: 353.91 E-value: 2.19e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 49 DGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLI 128
Cdd:cd05934 1 GRRWTYAELLRESARIAAALAALGIRPGDRVALMLDNCPEFLFAWFALAKLGAVLVPINTALRGDELAYIIDHSGAQLVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 129 CDaalegevvreviasieaegnaaprvfttraralqtrddprvfgtqreasgagegardllqaaqavqpgrkpppvvlaa 208
Cdd:cd05934 81 VD------------------------------------------------------------------------------ 82
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 209 sdPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLVGHIGAAWIARAPLILTHRFDPA 288
Cdd:cd05934 83 --PASILYTSGTTGPPKGVVITHANLTFAGYYSARRFGLGEDDVYLTVLPLFHINAQAVSVLAALSVGATLVLLPRFSAS 160
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 289 ATLDAIEEHRAEFT--IGAITVFiaLLHHADATREKLATLTKIYsgGAPIAPSVVEAFRAKFGHVIHGAYGLTETNSPTh 366
Cdd:cd05934 161 RFWSDVRRYGATVTnyLGAMLSY--LLAQPPSPDDRAHRLRAAY--GAPNPPELHEEFEERFGVRLLEGYGMTETIVGV- 235
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 367 mvplarTAPVDPHSGALAMGVPVPGAEAAIVDDDGNMLAAGETGEIVCR---GPMVVPGYWNNAAATADAFRGGWFHTGD 443
Cdd:cd05934 236 ------IGPRDEPRRPGSIGRPAPGYEVRIVDDDGQELPAGEPGELVIRglrGWGFFKGYYNMPEATAEAMRNGWFHTGD 309
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 444 VGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVADAAELIAFC 523
Cdd:cd05934 310 LGYRDADGFFYFVDRKKDMIRRRGENISSAEVERAILRHPAVREAAVVAVPDEVGEDEVKAVVVLRPGETLDPEELFAFC 389
|
490 500 510
....*....|....*....|....*....|...
gi 1595048490 524 KARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:cd05934 390 EGQLAYFKVPRYIRFVDDLPKTPTEKVAKAQLR 422
|
|
| FACL_fum10p_like |
cd05926 |
Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; FACL ... |
55-556 |
5.51e-114 |
|
Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; FACL catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, followed by the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Fum10p is a fatty acid CoA ligase involved in the synthesis of fumonisin, a polyketide mycotoxin, in Gibberella moniliformis.
Pssm-ID: 341249 [Multi-domain] Cd Length: 493 Bit Score: 347.38 E-value: 5.51e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 55 QALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLICDAALE 134
Cdd:cd05926 18 ADLAELVDDLARQLAALGIKKGDRVAIALPNGLEFVVAFLAAARAGAVVAPLNPAYKKAEFEFYLADLGSKLVLTPKGEL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 135 GEVVReviasieaegnAAPRVFTTRARAlqTRDDPRvfgtqreASGAGEGARdlLQAAQAVQPGRKPPPVVLAaSDPAML 214
Cdd:cd05926 98 GPASR-----------AASKLGLAILEL--ALDVGV-------LIRAPSAES--LSNLLADKKNAKSEGVPLP-DDLALI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 215 VYTSGTSGRPKGAICTHGNFAFNSQ----TYRdfcgLREGGPILGVAPLFHITGLVGHIGAAWIARAPLILTHRFDPAAT 290
Cdd:cd05926 155 LHTSGTTGRPKGVPLTHRNLAASATnitnTYK----LTPDDRTLVVMPLFHVHGLVASLLSTLAAGGSVVLPPRFSASTF 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 291 LDAIEEHRAEF-----TIGAITvfiaLLHHADATREKLATLTKIYSGGAPIAPSVVEAFRAKFGHVIHGAYGLTETNSPT 365
Cdd:cd05926 231 WPDVRDYNATWytavpTIHQIL----LNRPEPNPESPPPKLRFIRSCSASLPPAVLEALEATFGAPVLEAYGMTEAAHQM 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 366 HMVPLaRTAPVDPHSgalaMGVPVpGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWNNAAATAD-AFRGGWFHTGDV 444
Cdd:cd05926 307 TSNPL-PPGPRKPGS----VGKPV-GVEVRILDEDGEILPPGVVGEICLRGPNVTRGYLNNPEANAEaAFKDGWFRTGDL 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 445 GFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVADAAELIAFCK 524
Cdd:cd05926 381 GYLDADGYLFLTGRIKELINRGGEKISPLEVDGVLLSHPAVLEAVAFGVPDEKYGEEVAAAVVLREGASVTEEELRAFCR 460
|
490 500 510
....*....|....*....|....*....|..
gi 1595048490 525 ARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:cd05926 461 KHLAAFKVPKKVYFVDELPKTATGKIQRRKVA 492
|
|
| PRK06188 |
PRK06188 |
acyl-CoA synthetase; Validated |
18-556 |
3.54e-113 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 235731 [Multi-domain] Cd Length: 524 Bit Score: 346.59 E-value: 3.54e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 18 EPNPQQEYTNGLDMFAAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIW 97
Cdd:PRK06188 4 MADLLHSGATYGHLLVSALKRYPDRPALVLGDTRLTYGQLADRISRYIQAFEALGLGTGDAVALLSLNRPEVLMAIGAAQ 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 98 KAGAVMVPVNPMNRARELKLLLDDSQARVLICDAAlegevvreviasieaegnaaprVFTTRARALQTRDD--PRVFGTq 175
Cdd:PRK06188 84 LAGLRRTALHPLGSLDDHAYVLEDAGISTLIVDPA----------------------PFVERALALLARVPslKHVLTL- 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 176 reasGAGEGARDLLQAAQAVQPgrKPPPVVLAASDPAMLVYTSGTSGRPKGAICTH-GNFAFNSQTYRDFcGLREGGPIL 254
Cdd:PRK06188 141 ----GPVPDGVDLLAAAAKFGP--APLVAAALPPDIAGLAYTGGTTGKPKGVMGTHrSIATMAQIQLAEW-EWPADPRFL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 255 GVAPLFHITGLVghIGAAWIARAPLILTHRFDPAATLDAIEEHRAEFTIGAITVFIALLHHADATREKLATLTKIYSGGA 334
Cdd:PRK06188 214 MCTPLSHAGGAF--FLPTLLRGGTVIVLAKFDPAEVLRAIEEQRITATFLVPTMIYALLDHPDLRTRDLSSLETVYYGAS 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 335 PIAPS-VVEAFRaKFGHVIHGAYGLTETNSPTHMVPLARTAPVDPHSgALAMGVPVPGAEAAIVDDDGNMLAAGETGEIV 413
Cdd:PRK06188 292 PMSPVrLAEAIE-RFGPIFAQYYGQTEAPMVITYLRKRDHDPDDPKR-LTSCGRPTPGLRVALLDEDGREVAQGEVGEIC 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 414 CRGPMVVPGYWNNAAATADAFRGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGV 493
Cdd:PRK06188 370 VRGPLVMDGYWNRPEETAEAFRDGWLHTGDVAREDEDGFYYIVDRKKDMIVTGGFNVFPREVEDVLAEHPAVAQVAVIGV 449
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1595048490 494 PDPYRGETVKAVVSLRAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:PRK06188 450 PDEKWGEAVTAVVVLRPGAAVDAAELQAHVKERKGSVHAPKQVDFVDSLPLTALGKPDKKALR 512
|
|
| PRK06178 |
PRK06178 |
acyl-CoA synthetase; Validated |
38-555 |
1.16e-112 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 235724 [Multi-domain] Cd Length: 567 Bit Score: 346.64 E-value: 1.16e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 38 RAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKL 117
Cdd:PRK06178 45 ERPQRPAIIFYGHVITYAELDELSDRFAALLRQRGVGAGDRVAVFLPNCPQFHIVFFGILKLGAVHVPVSPLFREHELSY 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 118 LLDDSQARVLICDAALeGEVVREVIASIEAEgnaapRVFTTRARALQTRDDPRVF-GTQREASGAGEGARDLLQAAQAV- 195
Cdd:PRK06178 125 ELNDAGAEVLLALDQL-APVVEQVRAETSLR-----HVIVTSLADVLPAEPTLPLpDSLRAPRLAAAGAIDLLPALRACt 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 196 QPGRKPPPvvlAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPI-LGVAPLFHITGLVGHIGAAWI 274
Cdd:PRK06178 199 APVPLPPP---ALDALAALNYTGGTTGMPKGCEHTQRDMVYTAAAAYAVAVVGGEDSVfLSFLPEFWIAGENFGLLFPLF 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 275 ARAPLILTHRFDPAATLDAIEEHRAEFTIGAITVFIALLHHADATREKLATL--TKIYSGGAPIAPSVVEAFRAKFGHVI 352
Cdd:PRK06178 276 SGATLVLLARWDAVAFMAAVERYRVTRTVMLVDNAVELMDHPRFAEYDLSSLrqVRVVSFVKKLNPDYRQRWRALTGSVL 355
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 353 -HGAYGLTETNSPTHMVPLARTAPVDPHSGALAMGVPVPGAEAAIVD-DDGNMLAAGETGEIVCRGPMVVPGYWNNAAAT 430
Cdd:PRK06178 356 aEAAWGMTETHTCDTFTAGFQDDDFDLLSQPVFVGLPVPGTEFKICDfETGELLPLGAEGEIVVRTPSLLKGYWNKPEAT 435
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 431 ADAFRGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRA 510
Cdd:PRK06178 436 AEALRDGWLHTGDIGKIDEQGFLHYLGRRKEMLKVNGMSVFPSEVEALLGQHPAVLGSAVVGRPDPDKGQVPVAFVQLKP 515
|
490 500 510 520
....*....|....*....|....*....|....*....|....*
gi 1595048490 511 GAVADAAELIAFCKARMAAYKYPrIVEFRDELPKTATGKILRREL 555
Cdd:PRK06178 516 GADLTAAALQAWCRENMAVYKVP-EIRIVDALPMTATGKVRKQDL 559
|
|
| PRK05605 |
PRK05605 |
long-chain-fatty-acid--CoA ligase; Validated |
1-556 |
6.77e-110 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 235531 [Multi-domain] Cd Length: 573 Bit Score: 339.67 E-value: 6.77e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 1 MNAYERFPWRALYDTGIEPNPQQEYTNGLDMFAAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVA 80
Cdd:PRK05605 7 MSAFADKPWLQSYAPWTPHDLDYGDTTLVDLYDNAVARFGDRPALDFFGATTTYAELGKQVRRAAAGLRALGVRPGDRVA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 81 LYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLIC-------------DAALEGEVVREVIASIEA 147
Cdd:PRK05605 87 IVLPNCPQHIVAFYAVLRLGAVVVEHNPLYTAHELEHPFEDHGARVAIVwdkvaptverlrrTTPLETIVSVNMIAAMPL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 148 EGNAAPRVFTTRARAlqtrddprvfgtQREA-SGAGEGARD---LLQAAQAVQPGRKPPPVVlAASDPAMLVYTSGTSGR 223
Cdd:PRK05605 167 LQRLALRLPIPALRK------------ARAAlTGPAPGTVPwetLVDAAIGGDGSDVSHPRP-TPDDVALILYTSGTTGK 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 224 PKGAICTHGNFAFNSQTYRDFC-GLREGGP-ILGVAPLFHITGLVGHIGAAWIARAPLILTHRFDPAATLDAIEEHRAEF 301
Cdd:PRK05605 234 PKGAQLTHRNLFANAAQGKAWVpGLGDGPErVLAALPMFHAYGLTLCLTLAVSIGGELVLLPAPDIDLILDAMKKHPPTW 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 302 TIGAITVFIALlhhADATREKLATLTKI---YSGGAPIAPSVVEAFRAKFGHVIHGAYGLTETNspthmvPLARTAPVDP 378
Cdd:PRK05605 314 LPGVPPLYEKI---AEAAEERGVDLSGVrnaFSGAMALPVSTVELWEKLTGGLLVEGYGLTETS------PIIVGNPMSD 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 379 HSGALAMGVPVPGAEAAIVD--DDGNMLAAGETGEIVCRGPMVVPGYWNNAAATADAFRGGWFHTGDVGFMDEAGWFYLV 456
Cdd:PRK05605 385 DRRPGYVGVPFPDTEVRIVDpeDPDETMPDGEEGELLVRGPQVFKGYWNRPEETAKSFLDGWFRTGDVVVMEEDGFIRIV 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 457 DRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVADAAELIAFCKARMAAYKYPRIV 536
Cdd:PRK05605 465 DRIKELIITGGFNVYPAEVEEVLREHPGVEDAAVVGLPREDGSEEVVAAVVLEPGAALDPEGLRAYCREHLTRYKVPRRF 544
|
570 580
....*....|....*....|
gi 1595048490 537 EFRDELPKTATGKILRRELR 556
Cdd:PRK05605 545 YHVDELPRDQLGKVRRREVR 564
|
|
| AMP-binding |
pfam00501 |
AMP-binding enzyme; |
32-464 |
1.20e-108 |
|
AMP-binding enzyme;
Pssm-ID: 459834 [Multi-domain] Cd Length: 417 Bit Score: 331.20 E-value: 1.20e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 32 FAAALERAPHESALLYFDG-RLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMN 110
Cdd:pfam00501 1 LERQAARTPDKTALEVGEGrRLTYRELDERANRLAAGLRALGVGKGDRVAILLPNSPEWVVAFLACLKAGAVYVPLNPRL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 111 RARELKLLLDDSQARVLICDAALEGEVVREviasieaegnAAPRVFTTRARALQTRDDPRVFgtqreasgagegarDLLQ 190
Cdd:pfam00501 81 PAEELAYILEDSGAKVLITDDALKLEELLE----------ALGKLEVVKLVLVLDRDPVLKE--------------EPLP 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 191 AAQAVQPGRKPPPVVLAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFC----GLREGGPILGVAPLFHITGLV 266
Cdd:pfam00501 137 EEAKPADVPPPPPPPPDPDDLAYIIYTSGTTGKPKGVMLTHRNLVANVLSIKRVRprgfGLGPDDRVLSTLPLFHDFGLS 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 267 GHIGAAWIARAPLIL---THRFDPAATLDAIEEHRAEFTIGAITVFIALLHHADATREKLATLTKIYSGGAPIAPSVVEA 343
Cdd:pfam00501 217 LGLLGPLLAGATVVLppgFPALDPAALLELIERYKVTVLYGVPTLLNMLLEAGAPKRALLSSLRLVLSGGAPLPPELARR 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 344 FRAKFGHVIHGAYGLTETNSPTHMVPLARTAPVDPHSGalamGVPVPGAEAAIVDDD-GNMLAAGETGEIVCRGPMVVPG 422
Cdd:pfam00501 297 FRELFGGALVNGYGLTETTGVVTTPLPLDEDLRSLGSV----GRPLPGTEVKIVDDEtGEPVPPGEPGELCVRGPGVMKG 372
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 1595048490 423 YWNNAAATADAF-RGGWFHTGDVGFMDEAGWFYLVDRKKDMIN 464
Cdd:pfam00501 373 YLNDPELTAEAFdEDGWYRTGDLGRRDEDGYLEIVGRKKDQIK 415
|
|
| PRK06710 |
PRK06710 |
long-chain-fatty-acid--CoA ligase; Validated |
5-555 |
1.56e-108 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 180666 [Multi-domain] Cd Length: 563 Bit Score: 335.85 E-value: 1.56e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 5 ERFPWRALYDTgiepNPQQEYTNGLDmfaaalERAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQ 84
Cdd:PRK06710 13 EEIPSTISYDI----QPLHKYVEQMA------SRYPEKKALHFLGKDITFSVFHDKVKRFANYLQKLGVEKGDRVAIMLP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 85 NVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLICdaaleGEVVREVIASIEAEGNAAPRVFTTRARALQ 164
Cdd:PRK06710 83 NCPQAVIGYYGTLLAGGIVVQTNPLYTERELEYQLHDSGAKVILC-----LDLVFPRVTNVQSATKIEHVIVTRIADFLP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 165 TRDDPRVFGTQREASG--AGEGARDLLQAAQAVQPGRKPPPVVLA--ASDPAMLVYTSGTSGRPKGAICTHGNFAFNS-Q 239
Cdd:PRK06710 158 FPKNLLYPFVQKKQSNlvVKVSESETIHLWNSVEKEVNTGVEVPCdpENDLALLQYTGGTTGFPKGVMLTHKNLVSNTlM 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 240 TYRDFCGLREGGPI-LGVAPLFHITGLVGHIGAAWIARAPLILTHRFDPAATLDAIEEHRAEFTIGAITVFIALLHHADA 318
Cdd:PRK06710 238 GVQWLYNCKEGEEVvLGVLPFFHVYGMTAVMNLSIMQGYKMVLIPKFDMKMVFEAIKKHKVTLFPGAPTIYIALLNSPLL 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 319 TREKLATLTKIYSGGAPIAPSVVEAFRAKFGHVIHGAYGLTETNSPTHMVPL-ARTAPVdphsgalAMGVPVPGAEAAIV 397
Cdd:PRK06710 318 KEYDISSIRACISGSAPLPVEVQEKFETVTGGKLVEGYGLTESSPVTHSNFLwEKRVPG-------SIGVPWPDTEAMIM 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 398 D-DDGNMLAAGETGEIVCRGPMVVPGYWNNAAATADAFRGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVE 476
Cdd:PRK06710 391 SlETGEALPPGEIGEIVVKGPQIMKGYWNKPEETAAVLQDGWLHTGDVGYMDEDGFFYVKDRKKDMIVASGFNVYPREVE 470
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1595048490 477 DVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRREL 555
Cdd:PRK06710 471 EVLYEHEKVQEVVTIGVPDPYRGETVKAFVVLKEGTECSEEELNQFARKYLAAYKVPKVYEFRDELPKTTVGKILRRVL 549
|
|
| MACS_like |
cd05972 |
Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of ... |
57-556 |
2.44e-108 |
|
Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The acyl-CoA is a key intermediate in many important biosynthetic and catabolic processes.
Pssm-ID: 341276 [Multi-domain] Cd Length: 428 Bit Score: 330.84 E-value: 2.44e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 57 LDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLICDAalege 136
Cdd:cd05972 6 LKRESAKAANVLAKLGLRKGDRVAVLLPRVPELWAVILAVIKLGAVYVPLTTLLGPKDIEYRLEAAGAKAIVTDA----- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 137 vvreviasieaegnaaprvfttraralqtrddprvfgtqreasgagegardllqaaqavqpgrkpppvvlaaSDPAMLVY 216
Cdd:cd05972 81 ------------------------------------------------------------------------EDPALIYF 88
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 217 TSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLVGHIGAAWIARAPLILTH--RFDPAATLDAI 294
Cdd:cd05972 89 TSGTTGLPKGVLHTHSYPLGHIPTAAYWLGLRPDDIHWNIADPGWAKGAWSSFFGPWLLGATVFVYEgpRFDAERILELL 168
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 295 EEHRAEFTIGAITVFiALLHHADATREKLATLTKIYSGGAPIAPSVVEAFRAKFGHVIHGAYGLTETnspTHMVPLARTA 374
Cdd:cd05972 169 ERYGVTSFCGPPTAY-RMLIKQDLSSYKFSHLRLVVSAGEPLNPEVIEWWRAATGLPIRDGYGQTET---GLTVGNFPDM 244
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 375 PVDPHSgalaMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVP--GYWNNAAATADAFRGGWFHTGDVGFMDEAGW 452
Cdd:cd05972 245 PVKPGS----MGRPTPGYDVAIIDDDGRELPPGEEGDIAIKLPPPGLflGYVGDPEKTEASIRGDYYLTGDRAYRDEDGY 320
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 453 FYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGA---VADAAELIAFCKARMAA 529
Cdd:cd05972 321 FWFVGRADDIIKSSGYRIGPFEVESALLEHPAVAEAAVVGSPDPVRGEVVKAFVVLTSGYepsEELAEELQGHVKKVLAP 400
|
490 500
....*....|....*....|....*..
gi 1595048490 530 YKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:cd05972 401 YKYPREIEFVEELPKTISGKIRRVELR 427
|
|
| PRK07470 |
PRK07470 |
acyl-CoA synthetase; Validated |
38-556 |
4.60e-107 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 180988 [Multi-domain] Cd Length: 528 Bit Score: 330.85 E-value: 4.60e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 38 RAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKL 117
Cdd:PRK07470 19 RFPDRIALVWGDRSWTWREIDARVDALAAALAARGVRKGDRILVHSRNCNQMFESMFAAFRLGAVWVPTNFRQTPDEVAY 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 118 LLDDSQARVLICDAALEGEVvreviasiEAEGNAAPRVfttraralqtrddprvfgTQREASGAGEGARDLlQAAQAVQP 197
Cdd:PRK07470 99 LAEASGARAMICHADFPEHA--------AAVRAASPDL------------------THVVAIGGARAGLDY-EALVARHL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 198 GRKPPPVVLAASDPAMLVYTSGTSGRPKGAICTHGNFAF--NSQTYRDFCGLREGGPILGVAPLFHITGLVGHIGAAWIA 275
Cdd:PRK07470 152 GARVANAAVDHDDPCWFFFTSGTTGRPKAAVLTHGQMAFviTNHLADLMPGTTEQDASLVVAPLSHGAGIHQLCQVARGA 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 276 RAPLILTHRFDPAATLDAIEEHRAE--FTIGAITVFiaLLHHADATREKLATLTKIYSGGAPIAPSVVEAFRAKFGHVIH 353
Cdd:PRK07470 232 ATVLLPSERFDPAEVWALVERHRVTnlFTVPTILKM--LVEHPAVDRYDHSSLRYVIYAGAPMYRADQKRALAKLGKVLV 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 354 GAYGLTE-TNSPTHMVPLARTAPVDPHSGALAMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWNNAAATAD 432
Cdd:PRK07470 310 QYFGLGEvTGNITVLPPALHDAEDGPDARIGTCGFERTGMEVQIQDDEGRELPPGETGEICVIGPAVFAGYYNNPEANAK 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 433 AFRGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGA 512
Cdd:PRK07470 390 AFRDGWFRTGDLGHLDARGFLYITGRASDMYISGGSNVYPREIEEKLLTHPAVSEVAVLGVPDPVWGEVGVAVCVARDGA 469
|
490 500 510 520
....*....|....*....|....*....|....*....|....
gi 1595048490 513 VADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:PRK07470 470 PVDEAELLAWLDGKVARYKLPKRFFFWDALPKSGYGKITKKMVR 513
|
|
| PRK08974 |
PRK08974 |
long-chain-fatty-acid--CoA ligase FadD; |
8-556 |
2.74e-104 |
|
long-chain-fatty-acid--CoA ligase FadD;
Pssm-ID: 236359 [Multi-domain] Cd Length: 560 Bit Score: 324.70 E-value: 2.74e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 8 PWRALY--DTGIEPNPQQeYTNGLDMFAAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDE-GVQRGDRVALYLQ 84
Cdd:PRK08974 4 VWLNRYpaDVPAEINPDR-YQSLVDMFEQAVARYADQPAFINMGEVMTFRKLEERSRAFAAYLQNGlGLKKGDRVALMMP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 85 NVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQAR--VLICDAA--LEGEV----VREVIASIEAEGNAAPR-- 154
Cdd:PRK08974 83 NLLQYPIALFGILRAGMIVVNVNPLYTPRELEHQLNDSGAKaiVIVSNFAhtLEKVVfktpVKHVILTRMGDQLSTAKgt 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 155 ----VFTTRARALQTRDDPRVFgTQREASGAGegardllQAAQAVQPgrkpppvVLAASDPAMLVYTSGTSGRPKGAICT 230
Cdd:PRK08974 163 lvnfVVKYIKRLVPKYHLPDAI-SFRSALHKG-------RRMQYVKP-------ELVPEDLAFLQYTGGTTGVAKGAMLT 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 231 HGNFAFN----SQTYRDFcgLREGGPILGVA-PLFHITGLVG------HIGAawiaRAPLILTHRfDPAATLDAIEEHRA 299
Cdd:PRK08974 228 HRNMLANleqaKAAYGPL--LHPGKELVVTAlPLYHIFALTVncllfiELGG----QNLLITNPR-DIPGFVKELKKYPF 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 300 EFTIGAITVFIALLHHADATREKLATLTKIYSGGAPIAPSVVEAFRAKFG-HVIHGaYGLTETNspthmvPLARTAPVD- 377
Cdd:PRK08974 301 TAITGVNTLFNALLNNEEFQELDFSSLKLSVGGGMAVQQAVAERWVKLTGqYLLEG-YGLTECS------PLVSVNPYDl 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 378 -PHSGALamGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWNNAAATADAFRGGWFHTGDVGFMDEAGWFYLV 456
Cdd:PRK08974 374 dYYSGSI--GLPVPSTEIKLVDDDGNEVPPGEPGELWVKGPQVMLGYWQRPEATDEVIKDGWLATGDIAVMDEEGFLRIV 451
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 457 DRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKA-VVSLRAGAVADaaELIAFCKARMAAYKYPRI 535
Cdd:PRK08974 452 DRKKDMILVSGFNVYPNEIEDVVMLHPKVLEVAAVGVPSEVSGEAVKIfVVKKDPSLTEE--ELITHCRRHLTGYKVPKL 529
|
570 580
....*....|....*....|.
gi 1595048490 536 VEFRDELPKTATGKILRRELR 556
Cdd:PRK08974 530 VEFRDELPKSNVGKILRRELR 550
|
|
| CHC_CoA_lg |
cd05903 |
Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); ... |
51-556 |
5.32e-104 |
|
Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Cyclohexanecarboxylate-CoA ligase activates the aliphatic ring compound, cyclohexanecarboxylate, for degradation. It catalyzes the synthesis of cyclohexanecarboxylate-CoA thioesters in a two-step reaction involving the formation of cyclohexanecarboxylate-AMP anhydride, followed by the nucleophilic substitution of AMP by CoA.
Pssm-ID: 341229 [Multi-domain] Cd Length: 437 Bit Score: 319.71 E-value: 5.32e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 51 RLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLICd 130
Cdd:cd05903 1 RLTYSELDTRADRLAAGLAALGVGPGDVVAFQLPNWWEFAVLYLACLRIGAVTNPILPFFREHELAFILRRAKAKVFVV- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 131 aalegevvreviasieaegnaaprvfttraralqtrddPRVFGTQREASgagegardllqaaqavQPGrkpppvvlaasD 210
Cdd:cd05903 80 --------------------------------------PERFRQFDPAA----------------MPD-----------A 94
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 211 PAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLVGHIGAAWIARAPLILTHRFDPAAT 290
Cdd:cd05903 95 VALLLFTSGTTGEPKGVMHSHNTLSASIRQYAERLGLGPGDVFLVASPMAHQTGFVYGFTLPLLLGAPVVLQDIWDPDKA 174
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 291 LDAIEEHRAEFTIGAITVFIALLHHADATREKLATLTKIYSGGAPIAPSVVEAFRAKFGHVIHGAYGLTETNSPthmvpL 370
Cdd:cd05903 175 LALMREHGVTFMMGATPFLTDLLNAVEEAGEPLSRLRTFVCGGATVPRSLARRAAELLGAKVCSAYGSTECPGA-----V 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 371 ARTAPVDPHSGALAMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWNNAAATADAFRGGWFHTGDVGFMDEA 450
Cdd:cd05903 250 TSITPAPEDRRLYTDGRPLPGVEIKVVDDTGATLAPGVEGELLSRGPSVFLGYLDRPDLTADAAPEGWFRTGDLARLDED 329
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 451 GWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVADAAELIAFC-KARMAA 529
Cdd:cd05903 330 GYLRITGRSKDIIIRGGENIPVLEVEDLLLGHPGVIEAAVVALPDERLGERACAVVVTKSGALLTFDELVAYLdRQGVAK 409
|
490 500
....*....|....*....|....*..
gi 1595048490 530 YKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:cd05903 410 QYWPERLVHVDDLPRTPSGKVQKFRLR 436
|
|
| 4CL |
cd05904 |
4-Coumarate-CoA Ligase (4CL); 4-Coumarate:coenzyme A ligase is a key enzyme in the ... |
51-555 |
6.04e-102 |
|
4-Coumarate-CoA Ligase (4CL); 4-Coumarate:coenzyme A ligase is a key enzyme in the phenylpropanoid metabolic pathway for monolignol and flavonoid biosynthesis. It catalyzes the synthesis of hydroxycinnamate-CoA thioesters in a two-step reaction, involving the formation of hydroxycinnamate-AMP anhydride and the nucleophilic substitution of AMP by CoA. The phenylpropanoid pathway is one of the most important secondary metabolism pathways in plants and hydroxycinnamate-CoA thioesters are the precursors of lignin and other important phenylpropanoids.
Pssm-ID: 341230 [Multi-domain] Cd Length: 505 Bit Score: 316.87 E-value: 6.04e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 51 RLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLIcd 130
Cdd:cd05904 32 ALTYAELERRVRRLAAGLAKRGGRKGDVVLLLSPNSIEFPVAFLAVLSLGAVVTTANPLSTPAEIAKQVKDSGAKLAF-- 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 131 aalegeVVREVIASIEAegnAAPRVFTTraralqtrDDPRVfgtqreasgAGEGARDLLQAAQAVQPgrkpPPVVLAASD 210
Cdd:cd05904 110 ------TTAELAEKLAS---LALPVVLL--------DSAEF---------DSLSFSDLLFEADEAEP----PVVVIKQDD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 211 PAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGP--ILGVAPLFHITGLVGHIGAAWIARAPLILTHRFDPA 288
Cdd:cd05904 160 VAALLYSSGTTGRSKGVMLTHRNLIAMVAQFVAGEGSNSDSEdvFLCVLPMFHIYGLSSFALGLLRLGATVVVMPRFDLE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 289 ATLDAIEEHRAefTIGAIT--VFIALLHHADATREKLATLTKIYSGGAPIAPSVVEAFRAKFGHVIHG-AYGLTETNSPT 365
Cdd:cd05904 240 ELLAAIERYKV--THLPVVppIVLALVKSPIVDKYDLSSLRQIMSGAAPLGKELIEAFRAKFPNVDLGqGYGMTESTGVV 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 366 HMVPLARTAPVDPHSgalaMGVPVPGAEAAIVD-DDGNMLAAGETGEIVCRGPMVVPGYWNNAAATADAFRG-GWFHTGD 443
Cdd:cd05904 318 AMCFAPEKDRAKYGS----VGRLVPNVEAKIVDpETGESLPPNQTGELWIRGPSIMKGYLNNPEATAATIDKeGWLHTGD 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 444 VGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVADAAELIAFC 523
Cdd:cd05904 394 LCYIDEDGYLFIVDRLKELIKYKGFQVAPAELEALLLSHPEILDAAVIPYPDEEAGEVPMAFVVRKPGSSLTEDEIMDFV 473
|
490 500 510
....*....|....*....|....*....|..
gi 1595048490 524 KARMAAYKYPRIVEFRDELPKTATGKILRREL 555
Cdd:cd05904 474 AKQVAPYKKVRKVAFVDAIPKSPSGKILRKEL 505
|
|
| PRK07514 |
PRK07514 |
malonyl-CoA synthase; Validated |
26-556 |
2.40e-99 |
|
malonyl-CoA synthase; Validated
Pssm-ID: 181011 [Multi-domain] Cd Length: 504 Bit Score: 309.88 E-value: 2.40e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 26 TNGL-DMFAAALERaPHESALLYFDG-RLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVM 103
Cdd:PRK07514 2 NNNLfDALRAAFAD-RDAPFIETPDGlRYTYGDLDAASARLANLLVALGVKPGDRVAVQVEKSPEALALYLATLRAGAVF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 104 VPVNPMNRARELKLLLDDSQARVLICDAALEGEVvREViasieAEGNAAPRVFTtraralqtrddprvFGTQREASgage 183
Cdd:PRK07514 81 LPLNTAYTLAELDYFIGDAEPALVVCDPANFAWL-SKI-----AAAAGAPHVET--------------LDADGTGS---- 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 184 gardLLQAAQAVQPGRkpPPVVLAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHIT 263
Cdd:PRK07514 137 ----LLEAAAAAPDDF--ETVPRGADDLAAILYTSGTTGRSKGAMLSHGNLLSNALTLVDYWRFTPDDVLIHALPIFHTH 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 264 GLVGHIGAAWIARAPLILTHRFDPAATLDAIEehRAEFTIGAITVFIALLHHADATREKLATLTKIYSGGAPIAPSVVEA 343
Cdd:PRK07514 211 GLFVATNVALLAGASMIFLPKFDPDAVLALMP--RATVMMGVPTFYTRLLQEPRLTREAAAHMRLFISGSAPLLAETHRE 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 344 FRAKFGHVIHGAYGLTETNSPThmvplarTAPVDPHSGALAMGVPVPGAEAAIVD-DDGNMLAAGETGEIVCRGPMVVPG 422
Cdd:PRK07514 289 FQERTGHAILERYGMTETNMNT-------SNPYDGERRAGTVGFPLPGVSLRVTDpETGAELPPGEIGMIEVKGPNVFKG 361
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 423 YWNNAAATADAFRG-GWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGET 501
Cdd:PRK07514 362 YWRMPEKTAEEFRAdGFFITGDLGKIDERGYVHIVGRGKDLIISGGYNVYPKEVEGEIDELPGVVESAVIGVPHPDFGEG 441
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*
gi 1595048490 502 VKAVVSLRAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:PRK07514 442 VTAVVVPKPGAALDEAAILAALKGRLARFKQPKRVFFVDELPRNTMGKVQKNLLR 496
|
|
| PRK08315 |
PRK08315 |
AMP-binding domain protein; Validated |
13-556 |
4.88e-99 |
|
AMP-binding domain protein; Validated
Pssm-ID: 236236 [Multi-domain] Cd Length: 559 Bit Score: 310.97 E-value: 4.88e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 13 YDTGIEPNPQQEYTNGlDMFAAALERAPHESALLYFDG--RLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFV 90
Cdd:PRK08315 4 YVRGPTDVPLLEQTIG-QLLDRTAARYPDREALVYRDQglRWTYREFNEEVDALAKGLLALGIEKGDRVGIWAPNVPEWV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 91 MALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLICDAALEG----EVVREViasieaegnaAPRVFTTRARALQTR 166
Cdd:PRK08315 83 LTQFATAKIGAILVTINPAYRLSELEYALNQSGCKALIAADGFKDsdyvAMLYEL----------APELATCEPGQLQSA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 167 DDP---RVF--GTQRE---------ASGAGEGARDLLQAAQAVqpgrkpppvvLAASDPAMLVYTSGTSGRPKGAICTHG 232
Cdd:PRK08315 153 RLPelrRVIflGDEKHpgmlnfdelLALGRAVDDAELAARQAT----------LDPDDPINIQYTSGTTGFPKGATLTHR 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 233 NFAFNSQTYRDFCGLREGGPILGVAPLFHITGLV-GHIGAawiarapliLTH---------RFDPAATLDAIEEHRAEFT 302
Cdd:PRK08315 223 NILNNGYFIGEAMKLTEEDRLCIPVPLYHCFGMVlGNLAC---------VTHgatmvypgeGFDPLATLAAVEEERCTAL 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 303 IGAITVFIALLHHADATREKLATL-TKIYSGgapiAPSVVEAFRAkfghVIHG--------AYGLTETnSPthmV----- 368
Cdd:PRK08315 294 YGVPTMFIAELDHPDFARFDLSSLrTGIMAG----SPCPIEVMKR----VIDKmhmsevtiAYGMTET-SP---Vstqtr 361
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 369 ---PLA-RTAPVdphsgalamGVPVPGAEAAIVD-DDGNMLAAGETGEIVCRGPMVVPGYWNNAAATADAF-RGGWFHTG 442
Cdd:PRK08315 362 tddPLEkRVTTV---------GRALPHLEVKIVDpETGETVPRGEQGELCTRGYSVMKGYWNDPEKTAEAIdADGWMHTG 432
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 443 DVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVADAAELIAF 522
Cdd:PRK08315 433 DLAVMDEEGYVNIVGRIKDMIIRGGENIYPREIEEFLYTHPKIQDVQVVGVPDEKYGEEVCAWIILRPGATLTEEDVRDF 512
|
570 580 590
....*....|....*....|....*....|....
gi 1595048490 523 CKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:PRK08315 513 CRGKIAHYKIPRYIRFVDEFPMTVTGKIQKFKMR 546
|
|
| PRK07059 |
PRK07059 |
Long-chain-fatty-acid--CoA ligase; Validated |
8-556 |
4.18e-98 |
|
Long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 235923 [Multi-domain] Cd Length: 557 Bit Score: 308.49 E-value: 4.18e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 8 PWRALYDTGI--EPNPQQeYTNGLDMFAAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQN 85
Cdd:PRK07059 4 IWLKSYPPGVpaEIDASQ-YPSLADLLEESFRQYADRPAFICMGKAITYGELDELSRALAAWLQSRGLAKGARVAIMMPN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 86 VPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLIC--------DAALEGEVVREVI-ASI-EAEGNAAPRV 155
Cdd:PRK07059 83 VLQYPVAIAAVLRAGYVVVNVNPLYTPRELEHQLKDSGAEAIVVlenfattvQQVLAKTAVKHVVvASMgDLLGFKGHIV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 156 -FTTR-------ARALQtrddprvfGTQREASGAGEGARDLLQaaqavqpgrkppPVVLAASDPAMLVYTSGTSGRPKGA 227
Cdd:PRK07059 163 nFVVRrvkkmvpAWSLP--------GHVRFNDALAEGARQTFK------------PVKLGPDDVAFLQYTGGTTGVSKGA 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 228 ICTHGNFAFN---SQTYRDFCGLREGGP----ILGVAPLFHITGLV--GHIGAAWIARAPLILTHRfDPAATLDAIEEHR 298
Cdd:PRK07059 223 TLLHRNIVANvlqMEAWLQPAFEKKPRPdqlnFVCALPLYHIFALTvcGLLGMRTGGRNILIPNPR-DIPGFIKELKKYQ 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 299 AEFTIGAITVFIALLHHADATREKLATLTKIYSGGAPIAPSVVEAFRAKFGHVIHGAYGLTETnSPthmVPLARTAPVDP 378
Cdd:PRK07059 302 VHIFPAVNTLYNALLNNPDFDKLDFSKLIVANGGGMAVQRPVAERWLEMTGCPITEGYGLSET-SP---VATCNPVDATE 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 379 HSGALamGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWNNAAATADA-FRGGWFHTGDVGFMDEAGWFYLVD 457
Cdd:PRK07059 378 FSGTI--GLPLPSTEVSIRDDDGNDLPLGEPGEICIRGPQVMAGYWNRPDETAKVmTADGFFRTGDVGVMDERGYTKIVD 455
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 458 RKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVADaAELIAFCKARMAAYKYPRIVE 537
Cdd:PRK07059 456 RKKDMILVSGFNVYPNEIEEVVASHPGVLEVAAVGVPDEHSGEAVKLFVVKKDPALTE-EDVKAFCKERLTNYKRPKFVE 534
|
570
....*....|....*....
gi 1595048490 538 FRDELPKTATGKILRRELR 556
Cdd:PRK07059 535 FRTELPKTNVGKILRRELR 553
|
|
| PRK12583 |
PRK12583 |
acyl-CoA synthetase; Provisional |
30-556 |
3.75e-97 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 237145 [Multi-domain] Cd Length: 558 Bit Score: 305.93 E-value: 3.75e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 30 DMFAAALERAPHESALLYF--DGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVN 107
Cdd:PRK12583 22 DAFDATVARFPDREALVVRhqALRYTWRQLADAVDRLARGLLALGVQPGDRVGIWAPNCAEWLLTQFATARIGAILVNIN 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 108 PMNRARELKLLLDDSQARVLICDAALEGEVVREVIASIeaegnaAPRVFTTRARALQTRDDPRVFGTQREASGAGEGA-- 185
Cdd:PRK12583 102 PAYRASELEYALGQSGVRWVICADAFKTSDYHAMLQEL------LPGLAEGQPGALACERLPELRGVVSLAPAPPPGFla 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 186 -RDLLQAAQAVQPGR-KPPPVVLAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHIT 263
Cdd:PRK12583 176 wHELQARGETVSREAlAERQASLDRDDPINIQYTSGTTGFPKGATLSHHNILNNGYFVAESLGLTEHDRLCVPVPLYHCF 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 264 GLV-GHIGAAWIARAPLILTHRFDPAATLDAIEEHRAEFTIGAITVFIALLHHADATREKLATLTKIYSGGAPIAPSVVE 342
Cdd:PRK12583 256 GMVlANLGCMTVGACLVYPNEAFDPLATLQAVEEERCTALYGVPTMFIAELDHPQRGNFDLSSLRTGIMAGAPCPIEVMR 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 343 AFRAKFgHV--IHGAYGLTETNSPTHMvplarTAPVDPHSGALA-MGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMV 419
Cdd:PRK12583 336 RVMDEM-HMaeVQIAYGMTETSPVSLQ-----TTAADDLERRVEtVGRTQPHLEVKVVDPDGATVPRGEIGELCTRGYSV 409
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 420 VPGYWNNAAATADAF-RGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYR 498
Cdd:PRK12583 410 MKGYWNNPEATAESIdEDGWMHTGDLATMDEQGYVRIVGRSKDMIIRGGENIYPREIEEFLFTHPAVADVQVFGVPDEKY 489
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*...
gi 1595048490 499 GETVKAVVSLRAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:PRK12583 490 GEEIVAWVRLHPGHAASEEELREFCKARIAHFKVPRYFRFVDEFPMTVTGKVQKFRMR 547
|
|
| BCL_4HBCL |
cd05959 |
Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Benzoate ... |
44-556 |
1.61e-96 |
|
Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Benzoate CoA ligase and 4-hydroxybenzoate-coenzyme A ligase catalyze the first activating step for benzoate and 4-hydroxybenzoate catabolic pathways, respectively. Although these two enzymes share very high sequence homology, they have their own substrate preference. The reaction proceeds via a two-step process; the first ATP-dependent step forms the substrate-AMP intermediate, while the second step forms the acyl-CoA ester, releasing the AMP. Aromatic compounds represent the second most abundant class of organic carbon compounds after carbohydrates. Some bacteria can use benzoic acid or benzenoid compounds as the sole source of carbon and energy through degradation. Benzoate CoA ligase and 4-hydroxybenzoate-Coenzyme A ligase are key enzymes of this process.
Pssm-ID: 341269 [Multi-domain] Cd Length: 508 Bit Score: 302.75 E-value: 1.61e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 44 ALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQ 123
Cdd:cd05959 22 AFIDDAGSLTYAELEAEARRVAGALRALGVKREERVLLIMLDTVDFPTAFLGAIRAGIVPVPVNTLLTPDDYAYYLEDSR 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 124 ARVLIcdaalegevvreviasieAEGNAAPRVftTRARALQTRDDPRVFGTQREASGAGEGARDLLQAAQAVQPgrkpPP 203
Cdd:cd05959 102 ARVVV------------------VSGELAPVL--AAALTKSEHTLVVLIVSGGAGPEAGALLLAELVAAEAEQL----KP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 204 VVLAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTY-RDFCGLREGGPILGVAPLFHITGL-VGHIGAAWIARAPLIL 281
Cdd:cd05959 158 AATHADDPAFWLYSSGSTGRPKGVVHLHADIYWTAELYaRNVLGIREDDVCFSAAKLFFAYGLgNSLTFPLSVGATTVLM 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 282 THRFDPAATLDAIEEHRAEFTIGAITVFIALLHHADATREKLATLTKIYSGGAPIAPSVVEAFRAKFGHVIHGAYGLTET 361
Cdd:cd05959 238 PERPTPAAVFKRIRRYRPTVFFGVPTLYAAMLAAPNLPSRDLSSLRLCVSAGEALPAEVGERWKARFGLDILDGIGSTEM 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 362 nspTHMVPLARTAPVDPHSGalamGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWNNAAATADAFRGGWFHT 441
Cdd:cd05959 318 ---LHIFLSNRPGRVRYGTT----GKPVPGYEVELRDEDGGDVADGEPGELYVRGPSSATMYWNNRDKTRDTFQGEWTRT 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 442 GDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAV---ADAAE 518
Cdd:cd05959 391 GDKYVRDDDGFYTYAGRADDMLKVSGIWVSPFEVESALVQHPAVLEAAVVGVEDEDGLTKPKAFVVLRPGYEdseALEEE 470
|
490 500 510
....*....|....*....|....*....|....*...
gi 1595048490 519 LIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:cd05959 471 LKEFVKDRLAPYKYPRWIVFVDELPKTATGKIQRFKLR 508
|
|
| caiC |
PRK08008 |
putative crotonobetaine/carnitine-CoA ligase; Validated |
41-556 |
2.11e-96 |
|
putative crotonobetaine/carnitine-CoA ligase; Validated
Pssm-ID: 181195 [Multi-domain] Cd Length: 517 Bit Score: 302.76 E-value: 2.11e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 41 HESALLYFDGRLD-----WQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRAREL 115
Cdd:PRK08008 22 HKTALIFESSGGVvrrysYLELNEEINRTANLFYSLGIRKGDKVALHLDNCPEFIFCWFGLAKIGAIMVPINARLLREES 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 116 KLLLDDSQARVLICDAAlegevvreviasieaegnaaprvFTTRARALQTRDDPRVFGT--QREASGAGEGARDLLQAaQ 193
Cdd:PRK08008 102 AWILQNSQASLLVTSAQ-----------------------FYPMYRQIQQEDATPLRHIclTRVALPADDGVSSFTQL-K 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 194 AVQPGRKPPPVVLAASDPAMLVYTSGTSGRPKGAICTHGNFAFnSQTYRDF-CGLREGGPILGVAPLFHITGLVGHIGAA 272
Cdd:PRK08008 158 AQQPATLCYAPPLSTDDTAEILFTSGTTSRPKGVVITHYNLRF-AGYYSAWqCALRDDDVYLTVMPAFHIDCQCTAAMAA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 273 WIARAPLILTHRFDPAATLDAIEEHRAEFTiGAITVFIALL----------HHAdaTREKLATLtkiysggaPIAPSVVE 342
Cdd:PRK08008 237 FSAGATFVLLEKYSARAFWGQVCKYRATIT-ECIPMMIRTLmvqppsandrQHC--LREVMFYL--------NLSDQEKD 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 343 AFRAKFGHVIHGAYGLTETnspthMVPLARTAPVDPHSGAlAMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGpmvVPG 422
Cdd:PRK08008 306 AFEERFGVRLLTSYGMTET-----IVGIIGDRPGDKRRWP-SIGRPGFCYEAEIRDDHNRPLPAGEIGEICIKG---VPG 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 423 ------YWNNAAATADAFRG-GWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPD 495
Cdd:PRK08008 377 ktifkeYYLDPKATAKVLEAdGWLHTGDTGYVDEEGFFYFVDRRCNMIKRGGENVSCVELENIIATHPKIQDIVVVGIKD 456
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1595048490 496 PYRGETVKAVVSLRAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:PRK08008 457 SIRDEAIKAFVVLNEGETLSEEEFFAFCEQNMAKFKVPSYLEIRKDLPRNCSGKIIKKNLK 517
|
|
| MCS |
cd05941 |
Malonyl-CoA synthetase (MCS); MCS catalyzes the formation of malonyl-CoA in a two-step ... |
55-556 |
5.12e-95 |
|
Malonyl-CoA synthetase (MCS); MCS catalyzes the formation of malonyl-CoA in a two-step reaction consisting of the adenylation of malonate with ATP, followed by malonyl transfer from malonyl-AMP to CoA. Malonic acid and its derivatives are the building blocks of polyketides and malonyl-CoA serves as the substrate of polyketide synthases. Malonyl-CoA synthetase has broad substrate tolerance and can activate a variety of malonyl acid derivatives. MCS may play an important role in biosynthesis of polyketides, the important secondary metabolites with therapeutic and agrochemical utility.
Pssm-ID: 341264 [Multi-domain] Cd Length: 442 Bit Score: 296.89 E-value: 5.12e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 55 QALDAWSDRIaclLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLIcdaale 134
Cdd:cd05941 19 ARAARLANRL---LALGKDLRGDRVAFLAPPSAEYVVAQLAIWRAGGVAVPLNPSYPLAELEYVITDSEPSLVL------ 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 135 gevvreviasieaegnaaprvfttraralqtrddprvfgtqreasgagegardllqaaqavqpgrkpppvvlaasDPAML 214
Cdd:cd05941 90 ---------------------------------------------------------------------------DPALI 94
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 215 VYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLVGHIGAAWIARAPLILTHRFDPAATLDAI 294
Cdd:cd05941 95 LYTSGTTGRPKGVVLTHANLAANVRALVDAWRWTEDDVLLHVLPLHHVHGLVNALLCPLFAGASVEFLPKFDPKEVAISR 174
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 295 EEHRAEFTIGAITVFIALL--------HHADATREKLATLTKIYSGGAPIAPSVVEAFRAKFGHVIHGAYGLTETNspth 366
Cdd:cd05941 175 LMPSITVFMGVPTIYTRLLqyyeahftDPQFARAAAAERLRLMVSGSAALPVPTLEEWEAITGHTLLERYGMTEIG---- 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 367 mvpLARTAPVDPHSGALAMGVPVPGAEAAIVDDDGN-MLAAGETGEIVCRGPMVVPGYWNNAAATADAFRG-GWFHTGDV 444
Cdd:cd05941 251 ---MALSNPLDGERRPGTVGMPLPGVQARIVDEETGePLPRGEVGEIQVRGPSVFKEYWNKPEATKEEFTDdGWFKTGDL 327
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 445 GFMDEAGWFYLVDRKKDM-INAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVA-DAAELIAF 522
Cdd:cd05941 328 GVVDEDGYYWILGRSSVDiIKSGGYKVSALEIERVLLAHPGVSECAVIGVPDPDWGERVVAVVVLRAGAAAlSLEELKEW 407
|
490 500 510
....*....|....*....|....*....|....
gi 1595048490 523 CKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:cd05941 408 AKQRLAPYKRPRRLILVDELPRNAMGKVNKKELR 441
|
|
| PRK06839 |
PRK06839 |
o-succinylbenzoate--CoA ligase; |
40-555 |
1.20e-94 |
|
o-succinylbenzoate--CoA ligase;
Pssm-ID: 168698 [Multi-domain] Cd Length: 496 Bit Score: 297.54 E-value: 1.20e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 40 PHESALLYFDGRLDWQALDAWSDRIACLLLDE-GVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLL 118
Cdd:PRK06839 16 PDRIAIITEEEEMTYKQLHEYVSKVAAYLIYElNVKKGERIAILSQNSLEYIVLLFAIAKVECIAVPLNIRLTENELIFQ 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 119 LDDSQARVLICDAALEGevvreVIASIEAEGNAAPRVFTTRARALQtrddprvfgtQREASGAGEGARDllqaaqavqpg 198
Cdd:PRK06839 96 LKDSGTTVLFVEKTFQN-----MALSMQKVSYVQRVISITSLKEIE----------DRKIDNFVEKNES----------- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 199 rkpppvvlaasDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLVGHIGAAWIARAP 278
Cdd:PRK06839 150 -----------ASFIICYTSGTTGKPKGAVLTQENMFWNALNNTFAIDLTMHDRSIVLLPLFHIGGIGLFAFPTLFAGGV 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 279 LILTHRFDPAATLDAIEEHRAEFTIGAITVFIALLHHADATREKLATLTKIYSGGAPIAPSVVEAFRAKfGHVIHGAYGL 358
Cdd:PRK06839 219 IIVPRKFEPTKALSMIEKHKVTVVMGVPTIHQALINCSKFETTNLQSVRWFYNGGAPCPEELMREFIDR-GFLFGQGFGM 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 359 TETnSPTHMVPLARTAPVDPHSgalaMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWNNAAATADAFRGGW 438
Cdd:PRK06839 298 TET-SPTVFMLSEEDARRKVGS----IGKPVLFCDYELIDENKNKVEVGEVGELLIRGPNVMKEYWNRPDATEETIQDGW 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 439 FHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVADAAE 518
Cdd:PRK06839 373 LCTGDLARVDEDGFVYIVGRKKEMIISGGENIYPLEVEQVINKLSDVYEVAVVGRQHVKWGEIPIAFIVKKSSSVLIEKD 452
|
490 500 510
....*....|....*....|....*....|....*..
gi 1595048490 519 LIAFCKARMAAYKYPRIVEFRDELPKTATGKILRREL 555
Cdd:PRK06839 453 VIEHCRLFLAKYKIPKEIVFLKELPKNATGKIQKAQL 489
|
|
| PRK07786 |
PRK07786 |
long-chain-fatty-acid--CoA ligase; Validated |
40-556 |
3.03e-93 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 169098 [Multi-domain] Cd Length: 542 Bit Score: 295.53 E-value: 3.03e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 40 PHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLL 119
Cdd:PRK07786 31 PDAPALRFLGNTTTWRELDDRVAALAGALSRRGVGFGDRVLILMLNRTEFVESVLAANMLGAIAVPVNFRLTPPEIAFLV 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 120 DDSQARVLICDAALEGeVVREViasieaegnaaprvfttraralqtRDDPRVFGTQREASGAGE----GARDLLQAAqav 195
Cdd:PRK07786 111 SDCGAHVVVTEAALAP-VATAV------------------------RDIVPLLSTVVVAGGSSDdsvlGYEDLLAEA--- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 196 qpGRKPPPVVLAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVA-PLFHITGLvGHIGAAWI 274
Cdd:PRK07786 163 --GPAHAPVDIPNDSPALIMYTSGTTGRPKGAVLTHANLTGQAMTCLRTNGADINSDVGFVGvPLFHIAGI-GSMLPGLL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 275 ARAPLIL--THRFDPAATLDAIEEHRAEFTIGAITVFIALLHHADATREKLAtLTKIYSGGAPIAPSVVEAFRAKF-GHV 351
Cdd:PRK07786 240 LGAPTVIypLGAFDPGQLLDVLEAEKVTGIFLVPAQWQAVCAEQQARPRDLA-LRVLSWGAAPASDTLLRQMAATFpEAQ 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 352 IHGAYGLTETnSPTHMVPLARTAPVDPHSgalaMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWNNAAATA 431
Cdd:PRK07786 319 ILAAFGQTEM-SPVTCMLLGEDAIRKLGS----VGKVIPTVAARVVDENMNDVPVGEVGEIVYRAPTLMSGYWNNPEATA 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 432 DAFRGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAG 511
Cdd:PRK07786 394 EAFAGGWFHSGDLVRQDEEGYVWVVDRKKDMIISGGENIYCAEVENVLASHPDIVEVAVIGRADEKWGEVPVAVAAVRND 473
|
490 500 510 520
....*....|....*....|....*....|....*....|....*.
gi 1595048490 512 -AVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:PRK07786 474 dAALTLEDLAEFLTDRLARYKHPKALEIVDALPRNPAGKVLKTELR 519
|
|
| PRK08751 |
PRK08751 |
long-chain fatty acid--CoA ligase; |
8-556 |
5.55e-93 |
|
long-chain fatty acid--CoA ligase;
Pssm-ID: 181546 [Multi-domain] Cd Length: 560 Bit Score: 295.25 E-value: 5.55e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 8 PWRALYDTGIEPNPQ-QEYTNGLDMFAAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDE-GVQRGDRVALYLQN 85
Cdd:PRK08751 6 PWLQSYPAGVAAEIDlEQFRTVAEVFATSVAKFADRPAYHSFGKTITYREADQLVEQFAAYLLGElQLKKGDRVALMMPN 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 86 VPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLICDAALeGEVVREVIAsieaeGNAAPRVFTTRARALQT 165
Cdd:PRK08751 86 CLQYPIATFGVLRAGLTVVNVNPLYTPRELKHQLIDSGASVLVVIDNF-GTTVQQVIA-----DTPVKQVITTGLGDMLG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 166 RDDPRVFG----------TQREASGAgegardlLQAAQAVQPGRKP--PPVVLAASDPAMLVYTSGTSGRPKGAICTHGN 233
Cdd:PRK08751 160 FPKAALVNfvvkyvkklvPEYRINGA-------IRFREALALGRKHsmPTLQIEPDDIAFLQYTGGTTGVAKGAMLTHRN 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 234 FAFNSQTYRDFCG----LREGGPILGVA-PLFHITGLVGH------IGAAwiarAPLILTHRFDPAATLdaiEEHRAEFT 302
Cdd:PRK08751 233 LVANMQQAHQWLAgtgkLEEGCEVVITAlPLYHIFALTANglvfmkIGGC----NHLISNPRDMPGFVK---ELKKTRFT 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 303 I--GAITVFIALLHHADATREKLATLTKIYSGGAPIAPSVVEAFRAKFGHVIHGAYGLTETNSPTHMVPLArtapVDPHS 380
Cdd:PRK08751 306 AftGVNTLFNGLLNTPGFDQIDFSSLKMTLGGGMAVQRSVAERWKQVTGLTLVEAYGLTETSPAACINPLT----LKEYN 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 381 GALamGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWNNAAATADAFRG-GWFHTGDVGFMDEAGWFYLVDRK 459
Cdd:PRK08751 382 GSI--GLPIPSTDACIKDDAGTVLAIGEIGELCIKGPQVMKGYWKRPEETAKVMDAdGWLHTGDIARMDEQGFVYIVDRK 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 460 KDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVAdAAELIAFCKARMAAYKYPRIVEFR 539
Cdd:PRK08751 460 KDMILVSGFNVYPNEIEDVIAMMPGVLEVAAVGVPDEKSGEIVKVVIVKKDPALT-AEDVKAHARANLTGYKQPRIIEFR 538
|
570
....*....|....*..
gi 1595048490 540 DELPKTATGKILRRELR 556
Cdd:PRK08751 539 KELPKTNVGKILRRELR 555
|
|
| ttLC_FACS_AEE21_like |
cd12118 |
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; This ... |
36-556 |
1.10e-91 |
|
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; This family includes fatty acyl-CoA synthetases that can activate medium to long-chain fatty acids. These enzymes catalyze the ATP-dependent acylation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. Fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters. The fatty acyl-CoA synthetase from Thermus thermophiles in this family has been shown to catalyze the long-chain fatty acid, myristoyl acid. Also included in this family are acyl activating enzymes from Arabidopsis, which contains a large number of proteins from this family with up to 63 different genes, many of which are uncharacterized.
Pssm-ID: 341283 [Multi-domain] Cd Length: 486 Bit Score: 289.58 E-value: 1.10e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 36 LERA----PHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNR 111
Cdd:cd12118 10 LERAaavyPDRTSIVYGDRRYTWRQTYDRCRRLASALAALGISRGDTVAVLAPNTPAMYELHFGVPMAGAVLNALNTRLD 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 112 ARELKLLLDDSQARVLICDAALEGEvvreviasieaegnaaprvfttraralqtrddprvfgtqreasgagegarDLLQA 191
Cdd:cd12118 90 AEEIAFILRHSEAKVLFVDREFEYE--------------------------------------------------DLLAE 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 192 aqavqpGRKPPPVVLAAS--DPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLVGHI 269
Cdd:cd12118 120 ------GDPDFEWIPPADewDPIALNYTSGTTGRPKGVVYHHRGAYLNALANILEWEMKQHPVYLWTLPMFHCNGWCFPW 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 270 GAAWIARAPLILtHRFDPAATLDAIEEHRAEFTIGAITVFIALLHHADATREKLATLTKIYSGGAPIAPSVVEAFRAKFG 349
Cdd:cd12118 194 TVAAVGGTNVCL-RKVDAKAIYDLIEKHKVTHFCGAPTVLNMLANAPPSDARPLPHRVHVMTAGAPPPAAVLAKMEELGF 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 350 HVIHGaYGLTETNSPTHMVPLAR---TAPVDPHSGALA-MGVPVPGAEAAIVDDDGNMLAA---GET-GEIVCRGPMVVP 421
Cdd:cd12118 273 DVTHV-YGLTETYGPATVCAWKPewdELPTEERARLKArQGVRYVGLEEVDVLDPETMKPVprdGKTiGEIVFRGNIVMK 351
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 422 GYWNNAAATADAFRGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGET 501
Cdd:cd12118 352 GYLKNPEATAEAFRGGWFHSGDLAVIHPDGYIEIKDRSKDIIISGGENISSVEVEGVLYKHPAVLEAAVVARPDEKWGEV 431
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*
gi 1595048490 502 VKAVVSLRAGAVADAAELIAFCKARMAAYKYPRIVEFRdELPKTATGKILRRELR 556
Cdd:cd12118 432 PCAFVELKEGAKVTEEEIIAFCREHLAGFMVPKTVVFG-ELPKTSTGKIQKFVLR 485
|
|
| PRK05677 |
PRK05677 |
long-chain-fatty-acid--CoA ligase; Validated |
9-556 |
2.19e-90 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 168170 [Multi-domain] Cd Length: 562 Bit Score: 288.59 E-value: 2.19e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 9 WRALYDTGI--EPNPQqEYTNGLDMFAAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDE-GVQRGDRVALYLQN 85
Cdd:PRK05677 6 WKDKYPAGIaaEINPD-EYPNIQAVLKQSCQRFADKPAFSNLGKTLTYGELYKLSGAFAAWLQQHtDLKPGDRIAVQLPN 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 86 VPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLIC---DAALEGEV-----VREVIASIEAEGNAAPRVFT 157
Cdd:PRK05677 85 VLQYPVAVFGAMRAGLIVVNTNPLYTAREMEHQFNDSGAKALVClanMAHLAEKVlpktgVKHVIVTEVADMLPPLKRLL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 158 TRA------RALQTRDDPRVFGTqREASGAGEGardllQAAQAVQPgrkpppvvlAASDPAMLVYTSGTSGRPKGAICTH 231
Cdd:PRK05677 165 INAvvkhvkKMVPAYHLPQAVKF-NDALAKGAG-----QPVTEANP---------QADDVAVLQYTGGTTGVAKGAMLTH 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 232 GNFAFNSQTYRDFCG--LREGGPILgVAPL--FHITGLVGHIGAAWIARAPLIL-THRFDPAATLDAIEEHRAEFTIGAI 306
Cdd:PRK05677 230 RNLVANMLQCRALMGsnLNEGCEIL-IAPLplYHIYAFTFHCMAMMLIGNHNILiSNPRDLPAMVKELGKWKFSGFVGLN 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 307 TVFIALLHHADATREKLATLTKIYSGGAPIAPSVVEAFRAKFGHVIHGAYGLTETNspthmvPLARTAPVDpHSGALAMG 386
Cdd:PRK05677 309 TLFVALCNNEAFRKLDFSALKLTLSGGMALQLATAERWKEVTGCAICEGYGMTETS------PVVSVNPSQ-AIQVGTIG 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 387 VPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWNNAAATADAFRG-GWFHTGDVGFMDEAGWFYLVDRKKDMINA 465
Cdd:PRK05677 382 IPVPSTLCKVIDDDGNELPLGEVGELCVKGPQVMKGYWQRPEATDEILDSdGWLKTGDIALIQEDGYMRIVDRKKDMILV 461
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 466 AGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKT 545
Cdd:PRK05677 462 SGFNVYPNELEDVLAALPGVLQCAAIGVPDEKSGEAIKVFVVVKPGETLTKEQVMEHMRANLTGYKVPKAVEFRDELPTT 541
|
570
....*....|.
gi 1595048490 546 ATGKILRRELR 556
Cdd:PRK05677 542 NVGKILRRELR 552
|
|
| PRK13295 |
PRK13295 |
cyclohexanecarboxylate-CoA ligase; Reviewed |
29-556 |
1.57e-88 |
|
cyclohexanecarboxylate-CoA ligase; Reviewed
Pssm-ID: 171961 [Multi-domain] Cd Length: 547 Bit Score: 283.48 E-value: 1.57e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 29 LDMFAAALERAPHESALLYFDG------RLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAV 102
Cdd:PRK13295 27 NDDLDACVASCPDKTAVTAVRLgtgaprRFTYRELAALVDRVAVGLARLGVGRGDVVSCQLPNWWEFTVLYLACSRIGAV 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 103 MVPVNPMNRARELKLLLDDSQARVLICDAALEGEVVREVIASIEAEGNAAPRVFTTRAralqtrDDPRVFgtqreASGAG 182
Cdd:PRK13295 107 LNPLMPIFRERELSFMLKHAESKVLVVPKTFRGFDHAAMARRLRPELPALRHVVVVGG------DGADSF-----EALLI 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 183 EGARDLLQAAQAVQPGRKPPPvvlaaSDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHI 262
Cdd:PRK13295 176 TPAWEQEPDAPAILARLRPGP-----DDVTQLIYTSGTTGEPKGVMHTANTLMANIVPYAERLGLGADDVILMASPMAHQ 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 263 TGLVGHIGAAWIARAPLILTHRFDPAATLDAIEEHRAEFTIGAITVFIALLHHADATREKLATLTKIYSGGAPIAPSVVE 342
Cdd:PRK13295 251 TGFMYGLMMPVMLGATAVLQDIWDPARAAELIRTEGVTFTMASTPFLTDLTRAVKESGRPVSSLRTFLCAGAPIPGALVE 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 343 AFRAKFGHVIHGAYGLTETNSPThmvplaRTAPVDPHSGALAM-GVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVP 421
Cdd:PRK13295 331 RARAALGAKIVSAWGMTENGAVT------LTKLDDPDERASTTdGCPLPGVEVRVVDADGAPLPAGQIGRLQVRGCSNFG 404
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 422 GY-----WNNAAATadafrgGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDP 496
Cdd:PRK13295 405 GYlkrpqLNGTDAD------GWFDTGDLARIDADGYIRISGRSKDVIIRGGENIPVVEIEALLYRHPAIAQVAIVAYPDE 478
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1595048490 497 YRGETVKAVVSLRAGAVADAAELIAFCKA-RMAAYKYPRIVEFRDELPKTATGKI----LRRELR 556
Cdd:PRK13295 479 RLGERACAFVVPRPGQSLDFEEMVEFLKAqKVAKQYIPERLVVRDALPRTPSGKIqkfrLREMLR 543
|
|
| PRK08276 |
PRK08276 |
long-chain-fatty-acid--CoA ligase; Validated |
44-556 |
2.29e-88 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 236215 [Multi-domain] Cd Length: 502 Bit Score: 281.41 E-value: 2.29e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 44 ALLYFDGR-LDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDS 122
Cdd:PRK08276 3 VIMAPSGEvVTYGELEARSNRLAHGLRALGLREGDVVAILLENNPEFFEVYWAARRSGLYYTPINWHLTAAEIAYIVDDS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 123 QARVLICDAALegevvREVIASIEAEGNAAPRVFTTraralqtrddprvfgtqreASGAGEGARDLLQAAqAVQPGRKPP 202
Cdd:PRK08276 83 GAKVLIVSAAL-----ADTAAELAAELPAGVPLLLV-------------------VAGPVPGFRSYEEAL-AAQPDTPIA 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 203 PVVLAAsdpaMLVYTSGTSGRPKGAI--CTHGN-----FAFNSQTYRDFCGlREGGPILGVAPLFHiTGLVGHIGAAWIA 275
Cdd:PRK08276 138 DETAGA----DMLYSSGTTGRPKGIKrpLPGLDpdeapGMMLALLGFGMYG-GPDSVYLSPAPLYH-TAPLRFGMSALAL 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 276 RAPLILTHRFDPAATLDAIEEHRAEFTIGAITVFIALLHHADATREK--LATLTKIYSGGAPIAPSVVEAFRAKFGHVIH 353
Cdd:PRK08276 212 GGTVVVMEKFDAEEALALIERYRVTHSQLVPTMFVRMLKLPEEVRARydVSSLRVAIHAAAPCPVEVKRAMIDWWGPIIH 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 354 GAYGLTETNSPTHMVP---LARTAPVdphsgalamGVPVPGaEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWNNAAAT 430
Cdd:PRK08276 292 EYYASSEGGGVTVITSedwLAHPGSV---------GKAVLG-EVRILDEDGNELPPGEIGTVYFEMDGYPFEYHNDPEKT 361
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 431 ADAFRG-GWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLR 509
Cdd:PRK08276 362 AAARNPhGWVTVGDVGYLDEDGYLYLTDRKSDMIISGGVNIYPQEIENLLVTHPKVADVAVFGVPDEEMGERVKAVVQPA 441
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|
gi 1595048490 510 AGAVAD---AAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:PRK08276 442 DGADAGdalAAELIAWLRGRLAHYKCPRSIDFEDELPRTPTGKLYKRRLR 491
|
|
| MACS_like_3 |
cd05971 |
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ... |
61-556 |
3.09e-88 |
|
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. MACS enzymes are localized to mitochondria.
Pssm-ID: 341275 [Multi-domain] Cd Length: 439 Bit Score: 279.32 E-value: 3.09e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 61 SDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLICDAAlegevvre 140
Cdd:cd05971 16 SNRFANVLKEIGLEKGDRVGVFLSQGPECAIAHIAILRSGAIAVPLFALFGPEALEYRLSNSGASALVTDGS-------- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 141 viasieaegnaaprvfttraralqtrddprvfgtqreasgagegardllqaaqavqpgrkpppvvlaaSDPAMLVYTSGT 220
Cdd:cd05971 88 --------------------------------------------------------------------DDPALIIYTSGT 99
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 221 SGRPKGAICTH----GN-----FAFNsqtyrdfCGLREGGPILGVAPLFHITGLVGHIGAAWIARAPLiLTHR---FDPA 288
Cdd:cd05971 100 TGPPKGALHAHrvllGHlpgvqFPFN-------LFPRDGDLYWTPADWAWIGGLLDVLLPSLYFGVPV-LAHRmtkFDPK 171
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 289 ATLDAIEEHraeftiGAITVFI---AL---LHHADATREKLATLTKIYSGGAPIAPSVVEAFRAKFGHVIHGAYGLTETN 362
Cdd:cd05971 172 AALDLMSRY------GVTTAFLpptALkmmRQQGEQLKHAQVKLRAIATGGESLGEELLGWAREQFGVEVNEFYGQTECN 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 363 SPTHMVPLarTAPVDPHSgalaMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVP--GYWNNAAATADAFRGGWFH 440
Cdd:cd05971 246 LVIGNCSA--LFPIKPGS----MGKPIPGHRVAIVDDNGTPLPPGEVGEIAVELPDPVAflGYWNNPSATEKKMAGDWLL 319
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 441 TGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVAD---AA 517
Cdd:cd05971 320 TGDLGRKDSDGYFWYVGRDDDVITSSGYRIGPAEIEECLLKHPAVLMAAVVGIPDPIRGEIVKAFVVLNPGETPSdalAR 399
|
490 500 510
....*....|....*....|....*....|....*....
gi 1595048490 518 ELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:cd05971 400 EIQELVKTRLAAHEYPREIEFVNELPRTATGKIRRRELR 438
|
|
| ACLS-CaiC |
cd17637 |
acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; This family contains fatty acid CoA ... |
210-552 |
3.15e-88 |
|
acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; This family contains fatty acid CoA ligases, including acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II, most of which are yet to be characterized, but may be similar to Carnitine-CoA ligase (CaiC) which catalyzes the transfer of CoA to carnitine. Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341292 [Multi-domain] Cd Length: 333 Bit Score: 275.69 E-value: 3.15e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 210 DPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGL-----VGHIGAAwiarapLILTHR 284
Cdd:cd17637 1 DPFVIIHTAAVAGRPRGAVLSHGNLIAANLQLIHAMGLTEADVYLNMLPLFHIAGLnlalaTFHAGGA------NVVMEK 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 285 FDPAATLDAIEEHRAEFTIGAITVFIALLHHADATREKLATLtKIYSGGApiAPSVVEAFRAKFGHVIHGAYGLTETNSp 364
Cdd:cd17637 75 FDPAEALELIEEEKVTLMGSFPPILSNLLDAAEKSGVDLSSL-RHVLGLD--APETIQRFEETTGATFWSLYGQTETSG- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 365 thmvpLARTAPVDPHSGAlaMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWNNAAATADAFRGGWFHTGDV 444
Cdd:cd17637 151 -----LVTLSPYRERPGS--AGRPGPLVRVRIVDDNDRPVPAGETGEIVVRGPLVFQGYWNLPELTAYTFRNGWHHTGDL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 445 GFMDEAGWFYLVDRK--KDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVADAAELIAF 522
Cdd:cd17637 224 GRFDEDGYLWYAGRKpeKELIKPGGENVYPAEVEKVILEHPAIAEVCVIGVPDPKWGEGIKAVCVLKPGATLTADELIEF 303
|
330 340 350
....*....|....*....|....*....|
gi 1595048490 523 CKARMAAYKYPRIVEFRDELPKTATGKILR 552
Cdd:cd17637 304 VGSRIARYKKPRYVVFVEALPKTADGSIDR 333
|
|
| PRK12492 |
PRK12492 |
long-chain-fatty-acid--CoA ligase; Provisional |
23-556 |
3.18e-88 |
|
long-chain-fatty-acid--CoA ligase; Provisional
Pssm-ID: 171539 [Multi-domain] Cd Length: 562 Bit Score: 282.87 E-value: 3.18e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 23 QEYTNGLDMFAAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDE-GVQRGDRVALYLQNVPQFVMALLGIWKAGA 101
Cdd:PRK12492 21 AAYKSVVEVFERSCKKFADRPAFSNLGVTLSYAELERHSAAFAAYLQQHtDLVPGDRIAVQMPNVLQYPIAVFGALRAGL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 102 VMVPVNPMNRARELKLLLDDSQARVLICdAALEGEVVREVIASIEAEgnaapRVFTTRARALQTRDDPRVFGTQREASGA 181
Cdd:PRK12492 101 IVVNTNPLYTAREMRHQFKDSGARALVY-LNMFGKLVQEVLPDTGIE-----YLIEAKMGDLLPAAKGWLVNTVVDKVKK 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 182 GEGARDLLQAA---QAVQPGR--KPPPVVLAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLR--EGGPIL 254
Cdd:PRK12492 175 MVPAYHLPQAVpfkQALRQGRglSLKPVPVGLDDIAVLQYTGGTTGLAKGAMLTHGNLVANMLQVRACLSQLgpDGQPLM 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 255 GVA--------PLFHITGLVGHIGAAWIA-RAPLILTHRFDPAATLDAIEEHRAEFTIGAITVFIALLHHADATREKLAT 325
Cdd:PRK12492 255 KEGqevmiaplPLYHIYAFTANCMCMMVSgNHNVLITNPRDIPGFIKELGKWRFSALLGLNTLFVALMDHPGFKDLDFSA 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 326 LTKIYSGGAPIAPSVVEAFRAKFGHVIHGAYGLTETNspthmvPLARTAPVDPHSGALAMGVPVPGAEAAIVDDDGNMLA 405
Cdd:PRK12492 335 LKLTNSGGTALVKATAERWEQLTGCTIVEGYGLTETS------PVASTNPYGELARLGTVGIPVPGTALKVIDDDGNELP 408
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 406 AGETGEIVCRGPMVVPGYWNNAAATADAFRG-GWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPA 484
Cdd:PRK12492 409 LGERGELCIKGPQVMKGYWQQPEATAEALDAeGWFKTGDIAVIDPDGFVRIVDRKKDLIIVSGFNVYPNEIEDVVMAHPK 488
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1595048490 485 VREAAVVGVPDPYRGETVKAVVSLRAGAVaDAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:PRK12492 489 VANCAAIGVPDERSGEAVKLFVVARDPGL-SVEELKAYCKENFTGYKVPKHIVLRDSLPMTPVGKILRRELR 559
|
|
| ttLC_FACS_AlkK_like |
cd12119 |
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes ... |
51-556 |
4.70e-88 |
|
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes fatty acyl-CoA synthetases that can activate medium-chain to long-chain fatty acids. They catalyze the ATP-dependent acylation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters. The fatty acyl-CoA synthetase from Thermus thermophiles in this family catalyzes the long-chain fatty acid, myristoyl acid, while another member in this family, the AlkK protein identified from Pseudomonas oleovorans, targets medium chain fatty acids. This family also includes uncharacterized FACS proteins.
Pssm-ID: 341284 [Multi-domain] Cd Length: 518 Bit Score: 281.06 E-value: 4.70e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 51 RLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLICD 130
Cdd:cd12119 25 RYTYAEVAERARRLANALRRLGVKPGDRVATLAWNTHRHLELYYAVPGMGAVLHTINPRLFPEQIAYIINHAEDRVVFVD 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 131 AALEGevvreVIASIeaegnaAPRVFTTRARALQTRDDPRVfgtqrEASGAGEGARDLLQAAQavqPGRKPPPVVlAASD 210
Cdd:cd12119 105 RDFLP-----LLEAI------APRLPTVEHVVVMTDDAAMP-----EPAGVGVLAYEELLAAE---SPEYDWPDF-DENT 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 211 PAMLVYTSGTSGRPKGAICTH-----GNFAFNSQtyrDFCGLREGGPILGVAPLFHITGLvGHIGAAWIARAPLILTHRF 285
Cdd:cd12119 165 AAAICYTSGTTGNPKGVVYSHrslvlHAMAALLT---DGLGLSESDVVLPVVPMFHVNAW-GLPYAAAMVGAKLVLPGPY 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 286 DPAATLDA-IEEHRAEFTIGAITVFIALLHHADATREKLATLTKIYSGGAPIAPSVVEAFRAKFGHVIHgAYGLTETnSP 364
Cdd:cd12119 241 LDPASLAElIEREGVTFAAGVPTVWQGLLDHLEANGRDLSSLRRVVIGGSAVPRSLIEAFEERGVRVIH-AWGMTET-SP 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 365 THMV----PLARTAPVDPHSGALAM-GVPVPGAEAAIVDDDGNMLAA-GET-GEIVCRGPMVVPGYWNNAAATADAFRGG 437
Cdd:cd12119 319 LGTVarppSEHSNLSEDEQLALRAKqGRPVPGVELRIVDDDGRELPWdGKAvGELQVRGPWVTKSYYKNDEESEALTEDG 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 438 WFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVADAA 517
Cdd:cd12119 399 WLRTGDVATIDEDGYLTITDRSKDVIKSGGEWISSVELENAIMAHPAVAEAAVIGVPHPKWGERPLAVVVLKEGATVTAE 478
|
490 500 510
....*....|....*....|....*....|....*....
gi 1595048490 518 ELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:cd12119 479 ELLEFLADKVAKWWLPDDVVFVDEIPKTSTGKIDKKALR 517
|
|
| EntE |
COG1021 |
EntE, 2,3-dihydroxybenzoate-AMP synthase component of non-ribosomal peptide synthetase ... |
30-556 |
7.59e-88 |
|
EntE, 2,3-dihydroxybenzoate-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440644 [Multi-domain] Cd Length: 533 Bit Score: 280.88 E-value: 7.59e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 30 DMFAAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVmvPVN-- 107
Cdd:COG1021 29 DLLRRRAERHPDRIAVVDGERRLSYAELDRRADRLAAGLLALGLRPGDRVVVQLPNVAEFVIVFFALFRAGAI--PVFal 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 108 PMNRARELKLLLDDSQARVLICDAALEG----EVVREViasieAEGNAAPRVfttraralqtrddprVFgtqreASGAGE 183
Cdd:COG1021 107 PAHRRAEISHFAEQSEAVAYIIPDRHRGfdyrALAREL-----QAEVPSLRH---------------VL-----VVGDAG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 184 GARDLLQAAQAVQPGRKPPPvvlAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHIT 263
Cdd:COG1021 162 EFTSLDALLAAPADLSEPRP---DPDDVAFFQLSGGTTGLPKLIPRTHDDYLYSVRASAEICGLDADTVYLAALPAAHNF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 264 GLV--GHIGAAWiARAPLILTHRFDPAATLDAIEEHRAefTIGAITVFIAL--LHHADATREKLATLTKIYSGGAPIAPS 339
Cdd:COG1021 239 PLSspGVLGVLY-AGGTVVLAPDPSPDTAFPLIERERV--TVTALVPPLALlwLDAAERSRYDLSSLRVLQVGGAKLSPE 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 340 VVEAFRAKFGHVIHGAYGLTE-----T--NSPTHMVplARTapvdphsgalaMGVPV-PGAEAAIVDDDGNMLAAGETGE 411
Cdd:COG1021 316 LARRVRPALGCTLQQVFGMAEglvnyTrlDDPEEVI--LTT-----------QGRPIsPDDEVRIVDEDGNPVPPGEVGE 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 412 IVCRGPMVVPGYWNNAAATADAF-RGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAV 490
Cdd:COG1021 383 LLTRGPYTIRGYYRAPEHNARAFtPDGFYRTGDLVRRTPDGYLVVEGRAKDQINRGGEKIAAEEVENLLLAHPAVHDAAV 462
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1595048490 491 VGVPDPYRGETVKAVVSLRAGAVaDAAELIAFCKAR-MAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:COG1021 463 VAMPDEYLGERSCAFVVPRGEPL-TLAELRRFLRERgLAAFKLPDRLEFVDALPLTAVGKIDKKALR 528
|
|
| PRK08162 |
PRK08162 |
acyl-CoA synthetase; Validated |
22-556 |
5.92e-87 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236169 [Multi-domain] Cd Length: 545 Bit Score: 279.14 E-value: 5.92e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 22 QQEYTNGLDMFAAA---------LERA----PHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQ 88
Cdd:PRK08162 1 MNIYEQGLDRNAANyvpltplsfLERAaevyPDRPAVIHGDRRRTWAETYARCRRLASALARRGIGRGDTVAVLLPNIPA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 89 FVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLICDAALeGEVVREviasieaegnaaprvfttrARALQTRDD 168
Cdd:PRK08162 81 MVEAHFGVPMAGAVLNTLNTRLDAASIAFMLRHGEAKVLIVDTEF-AEVARE-------------------ALALLPGPK 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 169 PRVFGTQREASGAGEGARDLLQAAqavqpgrkpppvVLAASDPAM-------------LVYTSGTSGRPKGAICTHGNFA 235
Cdd:PRK08162 141 PLVIDVDDPEYPGGRFIGALDYEA------------FLASGDPDFawtlpadewdaiaLNYTSGTTGNPKGVVYHHRGAY 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 236 FNSQTYRDFCGLREGGPILGVAPLFHITGLvghiGAAWI--ARAPL-ILTHRFDPAATLDAIEEHRAEFTIGAITVFIAL 312
Cdd:PRK08162 209 LNALSNILAWGMPKHPVYLWTLPMFHCNGW----CFPWTvaARAGTnVCLRKVDPKLIFDLIREHGVTHYCGAPIVLSAL 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 313 LHHADATREKLATLTKIYSGGAPIAPSVVEAFRAKFGHVIHgAYGLTETNSPTHMV---PLARTAPVDPHSGALAM-GVP 388
Cdd:PRK08162 285 INAPAEWRAGIDHPVHAMVAGAAPPAAVIAKMEEIGFDLTH-VYGLTETYGPATVCawqPEWDALPLDERAQLKARqGVR 363
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 389 VPGAEAAIVDDDGNML---AAGET-GEIVCRGPMVVPGYWNNAAATADAFRGGWFHTGDVGFMDEAGWFYLVDRKKDMIN 464
Cdd:PRK08162 364 YPLQEGVTVLDPDTMQpvpADGETiGEIMFRGNIVMKGYLKNPKATEEAFAGGWFHTGDLAVLHPDGYIKIKDRSKDIII 443
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 465 AAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVADAAELIAFCKARMAAYKYPRIVEFrDELPK 544
Cdd:PRK08162 444 SGGENISSIEVEDVLYRHPAVLVAAVVAKPDPKWGEVPCAFVELKDGASATEEEIIAHCREHLAGFKVPKAVVF-GELPK 522
|
570
....*....|..
gi 1595048490 545 TATGKILRRELR 556
Cdd:PRK08162 523 TSTGKIQKFVLR 534
|
|
| PRK04319 |
PRK04319 |
acetyl-CoA synthetase; Provisional |
3-556 |
9.13e-87 |
|
acetyl-CoA synthetase; Provisional
Pssm-ID: 235279 [Multi-domain] Cd Length: 570 Bit Score: 279.47 E-value: 9.13e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 3 AYERFPWRAlydtgIEPNPQQEYTNGLDMFAAALERAPHES-----ALLYFDGRLD----WQALDAWSDRIACLLLDEGV 73
Cdd:PRK04319 21 TYATFSWEE-----VEKEFSWLETGKVNIAYEAIDRHADGGrkdkvALRYLDASRKekytYKELKELSNKFANVLKELGV 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 74 QRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLICDAALEGEVVREVIASIEAegnaap 153
Cdd:PRK04319 96 EKGDRVFIFMPRIPELYFALLGALKNGAIVGPLFEAFMEEAVRDRLEDSEAKVLITTPALLERKPADDLPSLKH------ 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 154 rVFttraralqtrddprVFGtqrEASGAGEGARDLLQAAQAVQPGRKPPPVvlAASDPAMLVYTSGTSGRPKGAICTHGN 233
Cdd:PRK04319 170 -VL--------------LVG---EDVEEGPGTLDFNALMEQASDEFDIEWT--DREDGAILHYTSGSTGKPKGVLHVHNA 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 234 FAFNSQTYRDFCGLREGGPILGVAPLFHITGLVGHIGAAWIARAPLILTH-RFDPAATLDAIEEHRAEFTIGAITVFIAL 312
Cdd:PRK04319 230 MLQHYQTGKYVLDLHEDDVYWCTADPGWVTGTSYGIFAPWLNGATNVIDGgRFSPERWYRILEDYKVTVWYTAPTAIRML 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 313 LHHADATREK--LATLTKIYSGGAPIAPSVVEAFRAKFGHVIHGAYGLTETNSptHMVPLARTAPVDPHSgalaMGVPVP 390
Cdd:PRK04319 310 MGAGDDLVKKydLSSLRHILSVGEPLNPEVVRWGMKVFGLPIHDNWWMTETGG--IMIANYPAMDIKPGS----MGKPLP 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 391 GAEAAIVDDDGNMLAAGETGEIVCRG--PMVVPGYWNNAAATADAFRGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGY 468
Cdd:PRK04319 384 GIEAAIVDDQGNELPPNRMGNLAIKKgwPSMMRGIWNNPEKYESYFAGDWYVSGDSAYMDEDGYFWFQGRVDDVIKTSGE 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 469 KVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVADAA---ELIAFCKARMAAYKYPRIVEFRDELPKT 545
Cdd:PRK04319 464 RVGPFEVESKLMEHPAVAEAGVIGKPDPVRGEIIKAFVALRPGYEPSEElkeEIRGFVKKGLGAHAAPREIEFKDKLPKT 543
|
570
....*....|.
gi 1595048490 546 ATGKILRRELR 556
Cdd:PRK04319 544 RSGKIMRRVLK 554
|
|
| ligase_PEP_1 |
TIGR03098 |
acyl-CoA ligase (AMP-forming), exosortase A-associated; This group of proteins contains an ... |
30-555 |
9.16e-87 |
|
acyl-CoA ligase (AMP-forming), exosortase A-associated; This group of proteins contains an AMP-binding domain (pfam00501) associated with acyl CoA-ligases. These proteins are generally found in genomes containing the exosortase/PEP-CTERM protein expoert system, specifically the type 1 variant of this system described by the Genome Property GenProp0652. When found in this context they are invariably present next to a decarboxylase enzyme. A number of sequences from Burkholderia species also hit this model, but the genomic context is obviously different. The hypothesis of a constant substrate for this family is only strong where the exosortase context is present.
Pssm-ID: 211788 [Multi-domain] Cd Length: 517 Bit Score: 277.82 E-value: 9.16e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 30 DMFAAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPM 109
Cdd:TIGR03098 4 HLLEDAAARLPDATALVHHDRTLTYAALSERVLALASGLRGLGLARGERVAIYLDKRLETVTAMFGAALAGGVFVPINPL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 110 NRARELKLLLDDSQARVLICDAALegevvrevIASIEAEGNAAPRVfttraRALQTRDDPrvfgTQREASGAGEGARDLl 189
Cdd:TIGR03098 84 LKAEQVAHILADCNVRLLVTSSER--------LDLLHPALPGCHDL-----RTLIIVGDP----AHASEGHPGEEPASW- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 190 QAAQAVQPGRKPPPVVlaASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLvGHI 269
Cdd:TIGR03098 146 PKLLALGDADPPHPVI--DSDMAAILYTSGSTGRPKGVVLSHRNLVAGAQSVATYLENRPDDRLLAVLPLSFDYGF-NQL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 270 GAAWIARAPLILTHRFDPAATLDAIEEHRAEfTIGAITVFIALLHHADATREKLATLTKIYSGGAPIAPSVVEAFRAKFG 349
Cdd:TIGR03098 223 TTAFYVGATVVLHDYLLPRDVLKALEKHGIT-GLAAVPPLWAQLAQLDWPESAAPSLRYLTNSGGAMPRATLSRLRSFLP 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 350 HV-IHGAYGLTETNSPTHMVPlartAPVDPHSGalAMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWNNAA 428
Cdd:TIGR03098 302 NArLFLMYGLTEAFRSTYLPP----EEVDRRPD--SIGKAIPNAEVLVLREDGSECAPGEEGELVHRGALVAMGYWNDPE 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 429 ATADAFR------------GGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDP 496
Cdd:TIGR03098 376 KTAERFRplppfpgelhlpELAVWSGDTVRRDEEGFLYFVGRRDEMIKTSGYRVSPTEVEEVAYATGLVAEAVAFGVPDP 455
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*....
gi 1595048490 497 YRGETVKAVVSLRAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRREL 555
Cdd:TIGR03098 456 TLGQAIVLVVTPPGGEELDRAALLAECRARLPNYMVPALIHVRQALPRNANGKIDRKAL 514
|
|
| PRK06145 |
PRK06145 |
acyl-CoA synthetase; Validated |
38-556 |
2.53e-86 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 102207 [Multi-domain] Cd Length: 497 Bit Score: 276.00 E-value: 2.53e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 38 RAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKL 117
Cdd:PRK06145 14 RTPDRAALVYRDQEISYAEFHQRILQAAGMLHARGIGQGDVVALLMKNSAAFLELAFAASYLGAVFLPINYRLAADEVAY 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 118 LLDDSQARVLICDAALEGEVvreviasieaeGNAAPRVFTTRAralqTRDDPRVFGTQREASgagegardllqaaqavqp 197
Cdd:PRK06145 94 ILGDAGAKLLLVDEEFDAIV-----------ALETPKIVIDAA----AQADSRRLAQGGLEI------------------ 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 198 grkPPPVVLAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHItGLVGHIGAAWIARA 277
Cdd:PRK06145 141 ---PPQAAVAPTDLVRLMYTSGTTDRPKGVMHSYGNLHWKSIDHVIALGLTASERLLVVGPLYHV-GAFDLPGIAVLWVG 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 278 PLILTHR-FDPAATLDAIEEHRAEFTIGAITVFIALLHHADATREKLATLTKIYSGGAPIAPSVVEAFRAKF--GHVIHg 354
Cdd:PRK06145 217 GTLRIHReFDPEAVLAAIERHRLTCAWMAPVMLSRVLTVPDRDRFDLDSLAWCIGGGEKTPESRIRDFTRVFtrARYID- 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 355 AYGLTETNSPTHMVPLARTApvdphSGALAMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWNNAAATADAF 434
Cdd:PRK06145 296 AYGLTETCSGDTLMEAGREI-----EKIGSTGRALAHVEIRIADGAGRWLPPNMKGEICMRGPKVTKGYWKDPEKTAEAF 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 435 RGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVA 514
Cdd:PRK06145 371 YGDWFRSGDVGYLDEEGFLYLTDRKKDMIISGGENIASSEVERVIYELPEVAEAAVIGVHDDRWGERITAVVVLNPGATL 450
|
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 1595048490 515 DAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:PRK06145 451 TLEALDRHCRQRLASFKVPRQLKVRDELPRNPSGKVLKRVLR 492
|
|
| MACS_like_4 |
cd05969 |
Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); This family is most ... |
61-556 |
3.66e-86 |
|
Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); This family is most similar to acetyl-CoA synthetase. Acetyl-CoA synthetase (ACS) catalyzes the formation of acetyl-CoA from acetate, CoA, and ATP. Synthesis of acetyl-CoA is carried out in a two-step reaction. In the first step, the enzyme catalyzes the synthesis of acetyl-AMP intermediate from acetate and ATP. In the second step, acetyl-AMP reacts with CoA to produce acetyl-CoA. This enzyme is only present in bacteria.
Pssm-ID: 341273 [Multi-domain] Cd Length: 442 Bit Score: 273.99 E-value: 3.66e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 61 SDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLIcdaalegevvre 140
Cdd:cd05969 10 SARFANVLKSLGVGKGDRVFVLSPRSPELYFSMLGIGKIGAVICPLFSAFGPEAIRDRLENSEAKVLI------------ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 141 viasieaegnAAPRvfttraraLQTRDDPRvfgtqreasgagegardllqaaqavqpgrkpppvvlaasDPAMLVYTSGT 220
Cdd:cd05969 78 ----------TTEE--------LYERTDPE---------------------------------------DPTLLHYTSGT 100
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 221 SGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLVGHIGAAWIARAPLILTH-RFDPAATLDAIEEHRA 299
Cdd:cd05969 101 TGTPKGVLHVHDAMIFYYFTGKYVLDLHPDDIYWCTADPGWVTGTVYGIWAPWLNGVTNVVYEgRFDAESWYGIIERVKV 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 300 EFTIGAITVFIALLHHADATREK--LATLTKIYSGGAPIAPSVVEAFRAKFGHVIHGAYGLTETNSptHMVPLARTAPVD 377
Cdd:cd05969 181 TVWYTAPTAIRMLMKEGDELARKydLSSLRFIHSVGEPLNPEAIRWGMEVFGVPIHDTWWQTETGS--IMIANYPCMPIK 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 378 PHSgalaMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRG--PMVVPGYWNNAAATADAFRGGWFHTGDVGFMDEAGWFYL 455
Cdd:cd05969 259 PGS----MGKPLPGVKAAVVDENGNELPPGTKGILALKPgwPSMFRGIWNDEERYKNSFIDGWYLTGDLAYRDEDGYFWF 334
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 456 VDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVADAA---ELIAFCKARMAAYKY 532
Cdd:cd05969 335 VGRADDIIKTSGHRVGPFEVESALMEHPAVAEAGVIGKPDPLRGEIIKAFISLKEGFEPSDElkeEIINFVRQKLGAHVA 414
|
490 500
....*....|....*....|....
gi 1595048490 533 PRIVEFRDELPKTATGKILRRELR 556
Cdd:cd05969 415 PREIEFVDNLPKTRSGKIMRRVLK 438
|
|
| MACS_AAE_MA_like |
cd05970 |
Medium-chain acyl-CoA synthetase (MACS) of AAE_MA like; MACS catalyzes the two-step activation ... |
28-556 |
6.55e-85 |
|
Medium-chain acyl-CoA synthetase (MACS) of AAE_MA like; MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This family of MACS enzymes is found in archaea and bacteria. It is represented by the acyl-adenylating enzyme from Methanosarcina acetivorans (AAE_MA). AAE_MA is most active with propionate, butyrate, and the branched analogs: 2-methyl-propionate, butyrate, and pentanoate. The specific activity is weaker for smaller or larger acids.
Pssm-ID: 341274 [Multi-domain] Cd Length: 537 Bit Score: 273.60 E-value: 6.55e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 28 GLDMFAAALERAPHESALLYFDG-----RLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAV 102
Cdd:cd05970 19 AYDVVDAMAKEYPDKLALVWCDDageerIFTFAELADYSDKTANFFKAMGIGKGDTVMLTLKRRYEFWYSLLALHKLGAI 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 103 MVPVNPMNRARELKLLLDDSQARVLICDAalEGEVVREVIASIEAEGNAAPRVfttraralQTRDDPRvfgtqreasgag 182
Cdd:cd05970 99 AIPATHQLTAKDIVYRIESADIKMIVAIA--EDNIPEEIEKAAPECPSKPKLV--------WVGDPVP------------ 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 183 EGARDLLQAAQAVQPGRKPP--PVVLAASDPAMLVYTSGTSGRPK----------GAICThGNFAFNsqtyrdfcgLREG 250
Cdd:cd05970 157 EGWIDFRKLIKNASPDFERPtaNSYPCGEDILLVYFSSGTTGMPKmvehdftyplGHIVT-AKYWQN---------VREG 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 251 GPILGVAPLFHITGLVGHIGAAWIARAPLIL--THRFDPAATLDAIEEHRAEFTIGAITVFIALLHhADATREKLATLTK 328
Cdd:cd05970 227 GLHLTVADTGWGKAVWGKIYGQWIAGAAVFVydYDKFDPKALLEKLSKYGVTTFCAPPTIYRFLIR-EDLSRYDLSSLRY 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 329 IYSGGAPIAPSVVEAFRAKFGHVIHGAYGLTETnspthMVPLARTAPVDPHSGAlaMGVPVPGAEAAIVDDDGNMLAAGE 408
Cdd:cd05970 306 CTTAGEALNPEVFNTFKEKTGIKLMEGFGQTET-----TLTIATFPWMEPKPGS--MGKPAPGYEIDLIDREGRSCEAGE 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 409 TGEIVCRGPMVVP-----GYWNNAAATADAFRGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHP 483
Cdd:cd05970 379 EGEIVIRTSKGKPvglfgGYYKDAEKTAEVWHDGYYHTGDAAWMDEDGYLWFVGRTDDLIKSSGYRIGPFEVESALIQHP 458
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1595048490 484 AVREAAVVGVPDPYRGETVKAVVSLRAGAVADAA---ELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:cd05970 459 AVLECAVTGVPDPIRGQVVKATIVLAKGYEPSEElkkELQDHVKKVTAPYKYPRIVEFVDELPKTISGKIRRVEIR 534
|
|
| FACL_like_2 |
cd05917 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ... |
210-556 |
6.99e-85 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341241 [Multi-domain] Cd Length: 349 Bit Score: 267.61 E-value: 6.99e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 210 DPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLVGHIGAAWIARAPLIL-THRFDPA 288
Cdd:cd05917 3 DVINIQFTSGTTGSPKGATLTHHNIVNNGYFIGERLGLTEQDRLCIPVPLFHCFGSVLGVLACLTHGATMVFpSPSFDPL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 289 ATLDAIEEHRAEFTIGAITVFIALLHHADATREKLATLTKIYSGGAPIAPSVVEAFRAKFGHV-IHGAYGLTETNSPTHM 367
Cdd:cd05917 83 AVLEAIEKEKCTALHGVPTMFIAELEHPDFDKFDLSSLRTGIMAGAPCPPELMKRVIEVMNMKdVTIAYGMTETSPVSTQ 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 368 vplarTAPVDP-HSGALAMGVPVPGAEAAIVDDDGNMLAA-GETGEIVCRGPMVVPGYWNNAAATADAFRG-GWFHTGDV 444
Cdd:cd05917 163 -----TRTDDSiEKRVNTVGRIMPHTEAKIVDPEGGIVPPvGVPGELCIRGYSVMKGYWNDPEKTAEAIDGdGWLHTGDL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 445 GFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVADAAELIAFCK 524
Cdd:cd05917 238 AVMDEDGYCRIVGRIKDMIIRGGENIYPREIEEFLHTHPKVSDVQVVGVPDERYGEEVCAWIRLKEGAELTEEDIKAYCK 317
|
330 340 350
....*....|....*....|....*....|..
gi 1595048490 525 ARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:cd05917 318 GKIAHYKVPRYVFFVDEFPLTVSGKIQKFKLR 349
|
|
| ABCL |
cd05958 |
2-aminobenzoate-CoA ligase (ABCL); ABCL catalyzes the initial step in the 2-aminobenzoate ... |
57-556 |
7.84e-84 |
|
2-aminobenzoate-CoA ligase (ABCL); ABCL catalyzes the initial step in the 2-aminobenzoate aerobic degradation pathway by activating 2-aminobenzoate to 2-aminobenzoyl-CoA. The reaction is carried out via a two-step process; the first step is ATP-dependent and forms a 2-aminobenzoyl-AMP intermediate, and the second step forms the 2-aminobenzoyl-CoA ester and releases the AMP. 2-Aminobenzoyl-CoA is further converted to 2-amino-5-oxo-cyclohex-1-ene-1-carbonyl-CoA catalyzed by 2-aminobenzoyl-CoA monooxygenase/reductase. ABCL has been purified from cells aerobically grown with 2-aminobenzoate as sole carbon, energy, and nitrogen source, and has been characterized as a monomer.
Pssm-ID: 341268 [Multi-domain] Cd Length: 439 Bit Score: 267.81 E-value: 7.84e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 57 LDAWSDRIACLLLDEGVQR-GDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLICDAALEg 135
Cdd:cd05958 16 LLALANRIANVLVGELGIVpGNRVLLRGSNSPELVACWFGIQKAGAIAVATMPLLRPKELAYILDKARITVALCAHALT- 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 136 evvreviasieaegnaaprvfttraralqtrddprvfgtqreasgagegardllqaaqavqpgrkpppvvlAASDPAMLV 215
Cdd:cd05958 95 -----------------------------------------------------------------------ASDDICILA 103
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 216 YTSGTSGRPKGAICTHGNFAFNSQTY-RDFCGLREGGPILGVAPLFHITGLVGHIGAAWIARAPLILTHRFDPAATLDAI 294
Cdd:cd05958 104 FTSGTTGAPKATMHFHRDPLASADRYaVNVLRLREDDRFVGSPPLAFTFGLGGVLLFPFGVGASGVLLEEATPDLLLSAI 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 295 EEHRAEFTIGAITVFIALLHHADATREKLATLTKIYSGGAPIAPSVVEAFRAKFGHVIHGAYGLTETnspTHMVPLARta 374
Cdd:cd05958 184 ARYKPTVLFTAPTAYRAMLAHPDAAGPDLSSLRKCVSAGEALPAALHRAWKEATGIPIIDGIGSTEM---FHIFISAR-- 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 375 PVDPHSGALamGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMvvpGYWNNAAATA-DAFRGGWFHTGDVGFMDEAGWF 453
Cdd:cd05958 259 PGDARPGAT--GKPVPGYEAKVVDDEGNPVPDGTIGRLAVRGPT---GCRYLADKRQrTYVQGGWNITGDTYSRDPDGYF 333
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 454 YLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVAD---AAELIAFCKARMAAY 530
Cdd:cd05958 334 RHQGRSDDMIVSGGYNIAPPEVEDVLLQHPAVAECAVVGHPDESRGVVVKAFVVLRPGVIPGpvlARELQDHAKAHIAPY 413
|
490 500
....*....|....*....|....*.
gi 1595048490 531 KYPRIVEFRDELPKTATGKILRRELR 556
Cdd:cd05958 414 KYPRAIEFVTELPRTATGKLQRFALR 439
|
|
| PRK06155 |
PRK06155 |
crotonobetaine/carnitine-CoA ligase; Provisional |
31-556 |
2.14e-83 |
|
crotonobetaine/carnitine-CoA ligase; Provisional
Pssm-ID: 235719 [Multi-domain] Cd Length: 542 Bit Score: 269.71 E-value: 2.14e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 31 MFAAALERAPhESALLYFDG-RLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPM 109
Cdd:PRK06155 26 MLARQAERYP-DRPLLVFGGtRWTYAEAARAAAAAAHALAAAGVKRGDRVALMCGNRIEFLDVFLGCAWLGAIAVPINTA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 110 NRARELKLLLDDSQARVLICDAALegevvREVIASIEAEGNAAPRVFTTraralqtrDDPRVFGTQREASGAGEGARDLL 189
Cdd:PRK06155 105 LRGPQLEHILRNSGARLLVVEAAL-----LAALEAADPGDLPLPAVWLL--------DAPASVSVPAGWSTAPLPPLDAP 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 190 QAAQAVQPGrkpppvvlaasDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLVGHI 269
Cdd:PRK06155 172 APAAAVQPG-----------DTAAILYTSGTTGPSKGVCCPHAQFYWWGRNSAEDLEIGADDVLYTTLPLFHTNALNAFF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 270 GAAwIARAPLILTHRFDPAATLDAIEEHRAEFT--IGAItVFIaLLHHADATREKLATLTKIYSGGAPiaPSVVEAFRAK 347
Cdd:PRK06155 241 QAL-LAGATYVLEPRFSASGFWPAVRRHGATVTylLGAM-VSI-LLSQPARESDRAHRVRVALGPGVP--AALHAAFRER 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 348 FGHVIHGAYGLTETNSPTHMVPLARTAPVdphsgalaMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGP---MVVPGYW 424
Cdd:PRK06155 316 FGVDLLDGYGSTETNFVIAVTHGSQRPGS--------MGRLAPGFEARVVDEHDQELPDGEPGELLLRADepfAFATGYF 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 425 NNAAATADAFRGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKA 504
Cdd:PRK06155 388 GMPEKTVEAWRNLWFHTGDRVVRDADGWFRFVDRIKDAIRRRGENISSFEVEQVLLSHPAVAAAAVFPVPSELGEDEVMA 467
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|..
gi 1595048490 505 VVSLRAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:PRK06155 468 AVVLRDGTALEPVALVRHCEPRLAYFAVPRYVEFVAALPKTENGKVQKFVLR 519
|
|
| OSB_CoA_lg |
cd05912 |
O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA ... |
57-556 |
3.23e-83 |
|
O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); O-succinylbenzoic acid-CoA synthase catalyzes the coenzyme A (CoA)- and ATP-dependent conversion of o-succinylbenzoic acid to o-succinylbenzoyl-CoA. The reaction is the fourth step of the biosynthesis pathway of menaquinone (vitamin K2). In certain bacteria, menaquinone is used during fumarate reduction in anaerobic respiration. In cyanobacteria, the product of the menaquinone pathway is phylloquinone (2-methyl-3-phytyl-1,4-naphthoquinone), a molecule used exclusively as an electron transfer cofactor in Photosystem 1. In green sulfur bacteria and heliobacteria, menaquinones are used as loosely bound secondary electron acceptors in the photosynthetic reaction center.
Pssm-ID: 341238 [Multi-domain] Cd Length: 411 Bit Score: 265.36 E-value: 3.23e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 57 LDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSqarvlicdaalegE 136
Cdd:cd05912 7 LFEEVSRLAEHLAALGVRKGDRVALLSKNSIEMILLIHALWLLGAEAVLLNTRLTPNELAFQLKDS-------------D 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 137 VVREVIASIeaegnaaprvfttraralqtrddprvfgtqreasgagegardllqaaqavqpgrkpppvvlaasdpamlVY 216
Cdd:cd05912 74 VKLDDIATI---------------------------------------------------------------------MY 84
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 217 TSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLvGHIGAAWIARAPLILTHRFDPAATLDAIEE 296
Cdd:cd05912 85 TSGTTGKPKGVQQTFGNHWWSAIGSALNLGLTEDDNWLCALPLFHISGL-SILMRSVIYGMTVYLVDKFDAEQVLHLINS 163
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 297 HRAEfTIGAITVFIALLHHADATREKlATLTKIYSGGAPIAPSVVEAFRAKfGHVIHGAYGLTETNSptHMVPLArtaPV 376
Cdd:cd05912 164 GKVT-IISVVPTMLQRLLEILGEGYP-NNLRCILLGGGPAPKPLLEQCKEK-GIPVYQSYGMTETCS--QIVTLS---PE 235
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 377 DPHSGALAMGVPVPGAEAAIVDDDGNmlaAGETGEIVCRGPMVVPGYWNNAAATADAFRGGWFHTGDVGFMDEAGWFYLV 456
Cdd:cd05912 236 DALNKIGSAGKPLFPVELKIEDDGQP---PYEVGEILLKGPNVTKGYLNRPDATEESFENGWFKTGDIGYLDEEGFLYVL 312
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 457 DRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGavADAAELIAFCKARMAAYKYPRIV 536
Cdd:cd05912 313 DRRSDLIISGGENIYPAEIEEVLLSHPAIKEAGVVGIPDDKWGQVPVAFVVSERP--ISEEELIAYCSEKLAKYKVPKKI 390
|
490 500
....*....|....*....|
gi 1595048490 537 EFRDELPKTATGKILRRELR 556
Cdd:cd05912 391 YFVDELPRTASGKLLRHELK 410
|
|
| PRK03640 |
PRK03640 |
o-succinylbenzoate--CoA ligase; |
55-556 |
5.17e-83 |
|
o-succinylbenzoate--CoA ligase;
Pssm-ID: 235146 [Multi-domain] Cd Length: 483 Bit Score: 266.83 E-value: 5.17e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 55 QALDAWSDRIACLlldeGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLICDAALE 134
Cdd:PRK03640 35 EAVVSVAGKLAAL----GVKKGDRVALLMKNGMEMILVIHALQQLGAVAVLLNTRLSREELLWQLDDAEVKCLITDDDFE 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 135 GEVVREVIASIEAEGNAAPRVFTTraraLQTRDDPRVfgtqreasgagegardllqaaqavqpgrkpppvvlaasdpAML 214
Cdd:PRK03640 111 AKLIPGISVKFAELMNGPKEEAEI----QEEFDLDEV----------------------------------------ATI 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 215 VYTSGTSGRPKGAICTHGNF-------AFNsqtyrdfCGLREGGPILGVAPLFHITGLvghigaAWIARA-----PLILT 282
Cdd:PRK03640 147 MYTSGTTGKPKGVIQTYGNHwwsavgsALN-------LGLTEDDCWLAAVPIFHISGL------SILMRSviygmRVVLV 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 283 HRFDPAATLDAIEEHRAEfTIGAITVFIALLHHADATREKLATLTKIYSGGAPIAPSVVEAFRAKFGHVIHgAYGLTETN 362
Cdd:PRK03640 214 EKFDAEKINKLLQTGGVT-IISVVSTMLQRLLERLGEGTYPSSFRCMLLGGGPAPKPLLEQCKEKGIPVYQ-SYGMTETA 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 363 SptHMVPLARTAPVDPHSGAlamGVPVPGAEAAIVDDdGNMLAAGETGEIVCRGPMVVPGYWNNAAATADAFRGGWFHTG 442
Cdd:PRK03640 292 S--QIVTLSPEDALTKLGSA---GKPLFPCELKIEKD-GVVVPPFEEGEIVVKGPNVTKGYLNREDATRETFQDGWFKTG 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 443 DVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVslRAGAVADAAELIAF 522
Cdd:PRK03640 366 DIGYLDEEGFLYVLDRRSDLIISGGENIYPAEIEEVLLSHPGVAEAGVVGVPDDKWGQVPVAFV--VKSGEVTEEELRHF 443
|
490 500 510
....*....|....*....|....*....|....
gi 1595048490 523 CKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:PRK03640 444 CEEKLAKYKVPKRFYFVEELPRNASGKLLRHELK 477
|
|
| PRK06087 |
PRK06087 |
medium-chain fatty-acid--CoA ligase; |
29-556 |
5.14e-81 |
|
medium-chain fatty-acid--CoA ligase;
Pssm-ID: 180393 [Multi-domain] Cd Length: 547 Bit Score: 263.53 E-value: 5.14e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 29 LDMFAAALERAPHESALLYFDG-RLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVN 107
Cdd:PRK06087 26 ADYWQQTARAMPDKIAVVDNHGaSYTYSALDHAASRLANWLLAKGIEPGDRVAFQLPGWCEFTIIYLACLKVGAVSVPLL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 108 PMNRARELKLLLDDSQARVLICdaalegevvreviASIEAEGNAAPRVFTTRARALQTRddpRVFGTQREASGAGEGArd 187
Cdd:PRK06087 106 PSWREAELVWVLNKCQAKMFFA-------------PTLFKQTRPVDLILPLQNQLPQLQ---QIVGVDKLAPATSSLS-- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 188 LLQAAQAVQPGRKPPPVvlAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLVG 267
Cdd:PRK06087 168 LSQIIADYEPLTTAITT--HGDELAAVLFTSGTEGLPKGVMLTHNNILASERAYCARLNLTWQDVFMMPAPLGHATGFLH 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 268 HIGAAWIARAPLILTHRFDPAATLDAIEEHRAEFTIGAiTVFIA-LLHHADATREKLATLTKIYSGGAPIAPSVVEafRA 346
Cdd:PRK06087 246 GVTAPFLIGARSVLLDIFTPDACLALLEQQRCTCMLGA-TPFIYdLLNLLEKQPADLSALRFFLCGGTTIPKKVAR--EC 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 347 KFGHV-IHGAYGLTETnSPTHMVPLARTAPVDPHSGalamGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWN 425
Cdd:PRK06087 323 QQRGIkLLSVYGSTES-SPHAVVNLDDPLSRFMHTD----GYAAAGVEIKVVDEARKTLPPGCEGEEASRGPNVFMGYLD 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 426 NAAATADAF-RGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKA 504
Cdd:PRK06087 398 EPELTARALdEEGWYYSGDLCRMDEAGYIKITGRKKDIIVRGGENISSREVEDILLQHPKIHDACVVAMPDERLGERSCA 477
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 1595048490 505 VVSLRAG-AVADAAELIAF-CKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:PRK06087 478 YVVLKAPhHSLTLEEVVAFfSRKRVAKYKYPEHIVVIDKLPRTASGKIQKFLLR 531
|
|
| FadD3 |
cd17638 |
acyl-CoA synthetase FadD3 and similar proteins; This family contains long chain fatty acid CoA ... |
210-552 |
1.07e-79 |
|
acyl-CoA synthetase FadD3 and similar proteins; This family contains long chain fatty acid CoA ligases, including FadD3 which is an acyl-CoA synthetase that initiates catabolism of cholesterol rings C and D in actinobacteria. The cholesterol catabolic pathway occurs in most mycolic acid-containing actinobacteria, such as Rhodococcus jostii RHA1, and is critical for Mycobacterium tuberculosis (Mtb) during infection. FadD3 catalyzes the ATP-dependent CoA thioesterification of 3a-alpha-H-4alpha(3'-propanoate)-7a-beta-methylhexahydro-1,5-indanedione (HIP) to yield HIP-CoA. Hydroxylated analogs of HIP, 5alpha-OH HIP and 1beta-OH HIP, can also be used.
Pssm-ID: 341293 [Multi-domain] Cd Length: 330 Bit Score: 253.19 E-value: 1.07e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 210 DPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLVGHIGAAWIARAPLILTHRFDPAA 289
Cdd:cd17638 1 DVSDIMFTSGTTGRSKGVMCAHRQTLRAAAAWADCADLTEDDRYLIINPFFHTFGYKAGIVACLLTGATVVPVAVFDVDA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 290 TLDAIEEHRAEFTIGAITVFIALLHHADATREKLATLTKIYSGGAPIAPSVVEAFRAKFG-HVIHGAYGLTETNspthMV 368
Cdd:cd17638 81 ILEAIERERITVLPGPPTLFQSLLDHPGRKKFDLSSLRAAVTGAATVPVELVRRMRSELGfETVLTAYGLTEAG----VA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 369 PLARTAPvDPHSGALAMGVPVPGAEAAIVDDdgnmlaagetGEIVCRGPMVVPGYWNNAAATADAFRG-GWFHTGDVGFM 447
Cdd:cd17638 157 TMCRPGD-DAETVATTCGRACPGFEVRIADD----------GEVLVRGYNVMQGYLDDPEATAEAIDAdGWLHTGDVGEL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 448 DEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVADAAELIAFCKARM 527
Cdd:cd17638 226 DERGYLRITDRLKDMYIVGGFNVYPAEVEGALAEHPGVAQVAVIGVPDERMGEVGKAFVVARPGVTLTEEDVIAWCRERL 305
|
330 340
....*....|....*....|....*
gi 1595048490 528 AAYKYPRIVEFRDELPKTATGKILR 552
Cdd:cd17638 306 ANYKVPRFVRFLDELPRNASGKVMK 330
|
|
| PRK12406 |
PRK12406 |
long-chain-fatty-acid--CoA ligase; Provisional |
42-556 |
1.81e-79 |
|
long-chain-fatty-acid--CoA ligase; Provisional
Pssm-ID: 183506 [Multi-domain] Cd Length: 509 Bit Score: 258.48 E-value: 1.81e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 42 ESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDD 121
Cdd:PRK12406 2 YATIISGDRRRSFDELAQRAARAAGGLAALGVRPGDCVALLMRNDFAFFEAAYAAMRLGAYAVPVNWHFKPEEIAYILED 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 122 SQARVLICDAALegevvREVIASIEAEGNAAPRVFTTRARALQTRDDPrvfgtqrEASGAGEGARDLLQAAQAVQPGRKP 201
Cdd:PRK12406 82 SGARVLIAHADL-----LHGLASALPAGVTVLSVPTPPEIAAAYRISP-------ALLTPPAGAIDWEGWLAQQEPYDGP 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 202 PpvvlaASDPAMLVYTSGTSGRPKG---AICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLVGHIGAAWIARAp 278
Cdd:PRK12406 150 P-----VPQPQSMIYTSGTTGHPKGvrrAAPTPEQAAAAEQMRALIYGLKPGIRALLTGPLYHSAPNAYGLRAGRLGGV- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 279 LILTHRFDPAATLDAIEEHRAEFTIGAITVFIALLHHADATREK--LATLTKIYSGGAPIAPSVVEAFRAKFGHVIHGAY 356
Cdd:PRK12406 224 LVLQPRFDPEELLQLIERHRITHMHMVPTMFIRLLKLPEEVRAKydVSSLRHVIHAAAPCPADVKRAMIEWWGPVIYEYY 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 357 GLTETNSpthmVPLARTAPVDPHSGALamGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPmVVPG--YWNNAAATADAF 434
Cdd:PRK12406 304 GSTESGA----VTFATSEDALSHPGTV--GKAAPGAELRFVDEDGRPLPQGEIGEIYSRIA-GNPDftYHNKPEKRAEID 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 435 RGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVA 514
Cdd:PRK12406 377 RGGFITSGDVGYLDADGYLFLCDRKRDMVISGGVNIYPAEIEAVLHAVPGVHDCAVFGIPDAEFGEALMAVVEPQPGATL 456
|
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 1595048490 515 DAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:PRK12406 457 DEADIRAQLKARLAGYKVPKHIEIMAELPREDSGKIFKRRLR 498
|
|
| PRK13391 |
PRK13391 |
acyl-CoA synthetase; Provisional |
51-556 |
6.53e-78 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 184022 [Multi-domain] Cd Length: 511 Bit Score: 254.62 E-value: 6.53e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 51 RLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLICD 130
Cdd:PRK13391 24 VVTYRELDERSNRLAHLFRSLGLKRGDHVAIFMENNLRYLEVCWAAERSGLYYTCVNSHLTPAEAAYIVDDSGARALITS 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 131 AAlEGEVVREVIAsieaegnAAPRVfttRARALQTRDdprvfgtqreasGAGEGARDLLQAAQAVQPGRKPPPVVLAAsd 210
Cdd:PRK13391 104 AA-KLDVARALLK-------QCPGV---RHRLVLDGD------------GELEGFVGYAEAVAGLPATPIADESLGTD-- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 211 pamLVYTSGTSGRPKGAICTHGNFAFNSQT-YRDFC----GLREGGPILGVAPLFH-----ITGLVGHIGAAwiarapLI 280
Cdd:PRK13391 159 ---MLYSSGTTGRPKGIKRPLPEQPPDTPLpLTAFLqrlwGFRSDMVYLSPAPLYHsapqrAVMLVIRLGGT------VI 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 281 LTHRFDPAATLDAIEEHRAEFTIGAITVFIALLHHADATREK--LATLTKIYSGGAPIAPSVVEAFRAKFGHVIHGAYGL 358
Cdd:PRK13391 230 VMEHFDAEQYLALIEEYGVTHTQLVPTMFSRMLKLPEEVRDKydLSSLEVAIHAAAPCPPQVKEQMIDWWGPIIHEYYAA 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 359 TETNSPTHMVP---LARTAPVdphsGALAMGVPVpgaeaaIVDDDGNMLAAGETGEIVCRG--PMVvpgYWNNAAATADA 433
Cdd:PRK13391 310 TEGLGFTACDSeewLAHPGTV----GRAMFGDLH------ILDDDGAELPPGEPGTIWFEGgrPFE---YLNDPAKTAEA 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 434 F--RGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAG 511
Cdd:PRK13391 377 RhpDGTWSTVGDIGYVDEDGYLYLTDRAAFMIISGGVNIYPQEAENLLITHPKVADAAVFGVPNEDLGEEVKAVVQPVDG 456
|
490 500 510 520
....*....|....*....|....*....|....*....|....*...
gi 1595048490 512 AVAD---AAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:PRK13391 457 VDPGpalAAELIAFCRQRLSRQKCPRSIDFEDELPRLPTGKLYKRLLR 504
|
|
| PRK07798 |
PRK07798 |
acyl-CoA synthetase; Validated |
30-549 |
3.21e-77 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236100 [Multi-domain] Cd Length: 533 Bit Score: 253.27 E-value: 3.21e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 30 DMFAAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPM 109
Cdd:PRK07798 7 DLFEAVADAVPDRVALVCGDRRLTYAELEERANRLAHYLIAQGLGPGDHVGIYARNRIEYVEAMLGAFKARAVPVNVNYR 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 110 NRARELKLLLDDSQARVLICDAALeGEVVREVIASieaegnaAPRVFTtrarALQTRDDPrvfgtqreASGAGEGARDLL 189
Cdd:PRK07798 87 YVEDELRYLLDDSDAVALVYEREF-APRVAEVLPR-------LPKLRT----LVVVEDGS--------GNDLLPGAVDYE 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 190 QAAQAVQPGRKPPPvvlAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDF---------------CGLREGGPIL 254
Cdd:PRK07798 147 DALAAGSPERDFGE---RSPDDLYLLYTGGTTGMPKGVMWRQEDIFRVLLGGRDFatgepiedeeelakrAAAGPGMRRF 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 255 GVAPLFHITGLVGHIGAAWIARAPLILT-HRFDPAATLDAIEEHRAefTIGAIT--VFIALLHHADATREK--LATLTKI 329
Cdd:PRK07798 224 PAPPLMHGAGQWAAFAALFSGQTVVLLPdVRFDADEVWRTIEREKV--NVITIVgdAMARPLLDALEARGPydLSSLFAI 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 330 YSGGAPIAPSVVEAFRAKFGHV-IHGAYGLTET-NSPTHMvplarTAPVDPHSGALAMGvpvPGAEAAIVDDDGNMLAAG 407
Cdd:PRK07798 302 ASGGALFSPSVKEALLELLPNVvLTDSIGSSETgFGGSGT-----VAKGAVHTGGPRFT---IGPRTVVLDEDGNPVEPG 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 408 --ETGEIVCRGPMVVpGYWNNAAATADAFR--GG--WFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYG 481
Cdd:PRK07798 374 sgEIGWIARRGHIPL-GYYKDPEKTAETFPtiDGvrYAIPGDRARVEADGTITLLGRGSVCINTGGEKVFPEEVEEALKA 452
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1595048490 482 HPAVREAAVVGVPDPYRGETVKAVVSLRAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGK 549
Cdd:PRK07798 453 HPDVADALVVGVPDERWGQEVVAVVQLREGARPDLAELRAHCRSSLAGYKVPRAIWFVDEVQRSPAGK 520
|
|
| PRK07788 |
PRK07788 |
acyl-CoA synthetase; Validated |
33-556 |
6.51e-77 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236097 [Multi-domain] Cd Length: 549 Bit Score: 252.93 E-value: 6.51e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 33 AAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRA 112
Cdd:PRK07788 56 AHAARRAPDRAALIDERGTLTYAELDEQSNALARGLLALGVRAGDGVAVLARNHRGFVLALYAAGKVGARIILLNTGFSG 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 113 RELKLLLDDSQARVLICDAAlegevvreviasieaegnaaprvFTTRARALQTR-DDPRVFGTQREASGAGEGARDLLQA 191
Cdd:PRK07788 136 PQLAEVAAREGVKALVYDDE-----------------------FTDLLSALPPDlGRLRAWGGNPDDDEPSGSTDETLDD 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 192 AQAVQPGRKPPpvvlAASDPAMLV-YTSGTSGRPKGAICTHGN-FAFNSQTYrDFCGLREGGPILGVAPLFHITGLvGHI 269
Cdd:PRK07788 193 LIAGSSTAPLP----KPPKPGGIViLTSGTTGTPKGAPRPEPSpLAPLAGLL-SRVPFRAGETTLLPAPMFHATGW-AHL 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 270 GAAWIARAPLILTHRFDPAATLDAIEEHRAEFTIGAITVFIALLHHADATREK--LATLTKIYSGGAPIAPSVVEAFRAK 347
Cdd:PRK07788 267 TLAMALGSTVVLRRRFDPEATLEDIAKHKATALVVVPVMLSRILDLGPEVLAKydTSSLKIIFVSGSALSPELATRALEA 346
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 348 FGHVIHGAYGLTEtnspthmVPLARTApvDPHSGALAMGV---PVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYW 424
Cdd:PRK07788 347 FGPVLYNLYGSTE-------VAFATIA--TPEDLAEAPGTvgrPPKGVTVKILDENGNEVPRGVVGRIFVGNGFPFEGYT 417
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 425 N-NAAATADafrgGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVK 503
Cdd:PRK07788 418 DgRDKQIID----GLLSSGDVGYFDEDGLLFVDGRDDDMIVSGGENVFPAEVEDLLAGHPDVVEAAVIGVDDEEFGQRLR 493
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|...
gi 1595048490 504 AVVSLRAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:PRK07788 494 AFVVKAPGAALDEDAIKDYVRDNLARYKVPRDVVFLDELPRNPTGKVLKRELR 546
|
|
| benz_CoA_lig |
TIGR02262 |
benzoate-CoA ligase family; Characterized members of this protein family include benzoate-CoA ... |
50-556 |
6.78e-76 |
|
benzoate-CoA ligase family; Characterized members of this protein family include benzoate-CoA ligase, 4-hydroxybenzoate-CoA ligase, 2-aminobenzoate-CoA ligase, etc. Members are related to fatty acid and acetate CoA ligases.
Pssm-ID: 274059 [Multi-domain] Cd Length: 505 Bit Score: 248.99 E-value: 6.78e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 50 GRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLIC 129
Cdd:TIGR02262 29 SSLSYGELEAQVRRLAAALRRLGVKREERVLLLMLDGVDFPIAFLGAIRAGIVPVALNTLLTADDYAYMLEDSRARVVFV 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 130 DAALEgEVVREVIASIEAEgnaaprvfttraralqtrddprvfgTQREASGAGE-GARDLLQAAQAVQPGRKPPPVvlAA 208
Cdd:TIGR02262 109 SGALL-PVIKAALGKSPHL-------------------------EHRVVVGRPEaGEVQLAELLATESEQFKPAAT--QA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 209 SDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTY-RDFCGLREGGPILGVAPLFHITGL-VGHIGAAWIARAPLILTHRFD 286
Cdd:TIGR02262 161 DDPAFWLYSSGSTGMPKGVVHTHSNPYWTAELYaRNTLGIREDDVCFSAAKLFFAYGLgNALTFPMSVGATTVLMGERPT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 287 PAATLDAIEEHRAEFTIGAITVFIALLHHADATREKLATLTKIYSGGAPIAPSVVEAFRAKFGHVIHGAYGLTETnspTH 366
Cdd:TIGR02262 241 PDAVFDRLRRHQPTIFYGVPTLYAAMLADPNLPSEDQVRLRLCTSAGEALPAEVGQRWQARFGVDIVDGIGSTEM---LH 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 367 MvpLARTAPVDPHSGAlaMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWNNAAATADAFRGGWFHTGDVGF 446
Cdd:TIGR02262 318 I--FLSNLPGDVRYGT--SGKPVPGYRLRLVGDGGQDVADGEPGELLISGPSSATMYWNNRAKSRDTFQGEWTRSGDKYV 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 447 MDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVADAAELIAFCKAR 526
Cdd:TIGR02262 394 RNDDGSYTYAGRTDDMLKVSGIYVSPFEIESALIQHPAVLEAAVVGVADEDGLIKPKAFVVLRPGQTALETELKEHVKDR 473
|
490 500 510
....*....|....*....|....*....|
gi 1595048490 527 MAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:TIGR02262 474 LAPYKYPRWIVFVDDLPKTATGKIQRFKLR 503
|
|
| FAA1 |
COG1022 |
Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]; |
30-492 |
8.93e-76 |
|
Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism];
Pssm-ID: 440645 [Multi-domain] Cd Length: 603 Bit Score: 251.17 E-value: 8.93e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 30 DMFAAALERAPHESALLYFDG----RLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVP 105
Cdd:COG1022 15 DLLRRRAARFPDRVALREKEDgiwqSLTWAEFAERVRALAAGLLALGVKPGDRVAILSDNRPEWVIADLAILAAGAVTVP 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 106 VNPMNRARELKLLLDDSQARVLICdaalEGEVVREVIASIEAEGNAAPRVFTTRARALqtRDDPRVFG-TQREASGAGEG 184
Cdd:COG1022 95 IYPTSSAEEVAYILNDSGAKVLFV----EDQEQLDKLLEVRDELPSLRHIVVLDPRGL--RDDPRLLSlDELLALGREVA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 185 ARDLLQAA-QAVQPgrkpppvvlaaSDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHI- 262
Cdd:COG1022 169 DPAELEARrAAVKP-----------DDLATIIYTSGTTGRPKGVMLTHRNLLSNARALLERLPLGPGDRTLSFLPLAHVf 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 263 --TGLVGHIGA----------------------------------------AWIARAPLILTHRFDPAATLdAIEEHRAE 300
Cdd:COG1022 238 erTVSYYALAAgatvafaespdtlaedlrevkptfmlavprvwekvyagiqAKAEEAGGLKRKLFRWALAV-GRRYARAR 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 301 FTIGAITVFIALLHH-ADAT-----REKLAT-LTKIYSGGAPIAPSVVEAFRAkFGHVIHGAYGLTETNSPTHMVPLARt 373
Cdd:COG1022 317 LAGKSPSLLLRLKHAlADKLvfsklREALGGrLRFAVSGGAALGPELARFFRA-LGIPVLEGYGLTETSPVITVNRPGD- 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 374 apVDPHSgalaMGVPVPGAEAAIvdddgnmlaaGETGEIVCRGPMVVPGYWNNAAATADAF-RGGWFHTGDVGFMDEAGW 452
Cdd:COG1022 395 --NRIGT----VGPPLPGVEVKI----------AEDGEILVRGPNVMKGYYKNPEATAEAFdADGWLHTGDIGELDEDGF 458
|
490 500 510 520
....*....|....*....|....*....|....*....|.
gi 1595048490 453 FYLVDRKKDMI-NAAGYKVWPREVEDVLYGHPAVREAAVVG 492
Cdd:COG1022 459 LRITGRKKDLIvTSGGKNVAPQPIENALKASPLIEQAVVVG 499
|
|
| menE |
TIGR01923 |
O-succinylbenzoate-CoA ligase; This model represents an enzyme, O-succinylbenzoate-CoA ligase, ... |
54-555 |
3.27e-75 |
|
O-succinylbenzoate-CoA ligase; This model represents an enzyme, O-succinylbenzoate-CoA ligase, which is involved in the fourth step of the menaquinone biosynthesis pathway. O-succinylbenzoate-CoA ligase, together with menB - naphtoate synthase, take 2-succinylbenzoate and convert it into 1,4-di-hydroxy-2- naphtoate. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]
Pssm-ID: 162605 [Multi-domain] Cd Length: 436 Bit Score: 245.05 E-value: 3.27e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 54 WQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLICDAAL 133
Cdd:TIGR01923 2 WQDLDCEAAHLAKALKAQGIRSGSRVALVGQNSIEMVLLLHACLLLGAEIAMLNTRLTENERTNQLEDLDVQLLLTDSLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 134 EGEVVREVIAS-IEAEGNAAprvfttraralqtrddprvfgTQREASGAGEgardllqaaqavqpgrkpppvvlaasDPA 212
Cdd:TIGR01923 82 EEKDFQADSLDrIEAAGRYE---------------------TSLSASFNMD--------------------------QIA 114
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 213 MLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLvGHIGAAWIARAPLILTHRFdpAATLD 292
Cdd:TIGR01923 115 TLMFTSGTTGKPKAVPHTFRNHYASAVGSKENLGFTEDDNWLLSLPLYHISGL-SILFRWLIEGATLRIVDKF--NQLLE 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 293 AIEEHRAEFtIGAITVFIALLHHADATREklaTLTKIYSGGAPI-APSVVEAfrAKFGHVIHGAYGLTETNSPThmvpla 371
Cdd:TIGR01923 192 MIANERVTH-ISLVPTQLNRLLDEGGHNE---NLRKILLGGSAIpAPLIEEA--QQYGLPIYLSYGMTETCSQV------ 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 372 RTAPVDPHSGALAMGVPVPGAEAAIVDDDgnmlaAGETGEIVCRGPMVVPGYWNNAAATADAFRGGWFHTGDVGFMDEAG 451
Cdd:TIGR01923 260 TTATPEMLHARPDVGRPLAGREIKIKVDN-----KEGHGEIMVKGANLMKGYLYQGELTPAFEQQGWFNTGDIGELDGEG 334
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 452 WFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGavADAAELIAFCKARMAAYK 531
Cdd:TIGR01923 335 FLYVLGRRDDLIISGGENIYPEEIETVLYQHPGIQEAVVVPKPDAEWGQVPVAYIVSESD--ISQAKLIAYLTEKLAKYK 412
|
490 500
....*....|....*....|....
gi 1595048490 532 YPRIVEFRDELPKTATGKILRREL 555
Cdd:TIGR01923 413 VPIAFEKLDELPYNASGKILRNQL 436
|
|
| PRK09088 |
PRK09088 |
acyl-CoA synthetase; Validated |
51-556 |
4.82e-75 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 181644 [Multi-domain] Cd Length: 488 Bit Score: 246.26 E-value: 4.82e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 51 RLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLICD 130
Cdd:PRK09088 22 RWTYAELDALVGRLAAVLRRRGCVDGERLAVLARNSVWLVALHFACARVGAIYVPLNWRLSASELDALLQDAEPRLLLGD 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 131 AALegevvreviasieaegnAAPRVfttraralqtrddprvfgtqreasgAGEGARDLLQAAQAVQPGRKPPpvvLAASD 210
Cdd:PRK09088 102 DAV-----------------AAGRT-------------------------DVEDLAAFIASADALEPADTPS---IPPER 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 211 PAMLVYTSGTSGRPKGAICTHGNFafnSQTYRDFCGLREGGP---ILGVAPLFHITGLVGHIGAAWIARAPLILTHRFDP 287
Cdd:PRK09088 137 VSLILFTSGTSGQPKGVMLSERNL---QQTAHNFGVLGRVDAhssFLCDAPMFHIIGLITSVRPVLAVGGSILVSNGFEP 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 288 AATLDAIeehrAEFTIGaITVFIALLHHADATREK-------LATLTKIYSGGAPIAPSVVEAFRAKFGHVIHGaYGLTE 360
Cdd:PRK09088 214 KRTLGRL----GDPALG-ITHYFCVPQMAQAFRAQpgfdaaaLRHLTALFTGGAPHAAEDILGWLDDGIPMVDG-FGMSE 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 361 TNSPTHMvplartaPVDP---HSGALAMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWNNAAATADAFRG- 436
Cdd:PRK09088 288 AGTVFGM-------SVDCdviRAKAGAAGIPTPTVQTRVVDDQGNDCPAGVPGELLLRGPNLSPGYWRRPQATARAFTGd 360
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 437 GWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVADA 516
Cdd:PRK09088 361 GWFRTGDIARRDADGFFWVVDRKKDMFISGGENVYPAEIEAVLADHPGIRECAVVGMADAQWGEVGYLAIVPADGAPLDL 440
|
490 500 510 520
....*....|....*....|....*....|....*....|
gi 1595048490 517 AELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:PRK09088 441 ERIRSHLSTRLAKYKVPKHLRLVDALPRTASGKLQKARLR 480
|
|
| MACS_like_2 |
cd05973 |
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ... |
52-556 |
2.30e-72 |
|
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. MACS enzymes are localized to mitochondria.
Pssm-ID: 341277 [Multi-domain] Cd Length: 437 Bit Score: 237.80 E-value: 2.30e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 52 LDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLICDA 131
Cdd:cd05973 1 LTFGELRALSARFANALQELGVGPGDVVAGLLPRTPELVVTILGIWRLGAVYQPLFTAFGPKAIEHRLRTSGARLVVTDA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 132 AlegevvreviasieaegnaaprvfttraralqtrddprvfgtqreasgagegARDLLqaaqavqpgrkpppvvlaASDP 211
Cdd:cd05973 81 A----------------------------------------------------NRHKL------------------DSDP 90
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 212 AMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLVGHIGAAWIARAPLILTHR-FDPAAT 290
Cdd:cd05973 91 FVMMFTSGTTGLPKGVPVPLRALAAFGAYLRDAVDLRPEDSFWNAADPGWAYGLYYAITGPLALGHPTILLEGgFSVEST 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 291 LDAIEEHRAEFTIGAITVFIALLHH--ADATREKLaTLTKIYSGGAPIAPSVVEAFRAKFGHVIHGAYGLTETNspthMV 368
Cdd:cd05973 171 WRVIERLGVTNLAGSPTAYRLLMAAgaEVPARPKG-RLRRVSSAGEPLTPEVIRWFDAALGVPIHDHYGQTELG----MV 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 369 PLARTAPVDP-HSGAlaMGVPVPGAEAAIVDDDGNMLAAGETGEI---VCRGP-MVVPGYWNNAAATADafrGGWFHTGD 443
Cdd:cd05973 246 LANHHALEHPvHAGS--AGRAMPGWRVAVLDDDGDELGPGEPGRLaidIANSPlMWFRGYQLPDTPAID---GGYYLTGD 320
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 444 VGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAG---AVADAAELI 520
Cdd:cd05973 321 TVEFDPDGSFSFIGRADDVITMSGYRIGPFDVESALIEHPAVAEAAVIGVPDPERTEVVKAFVVLRGGhegTPALADELQ 400
|
490 500 510
....*....|....*....|....*....|....*.
gi 1595048490 521 AFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:cd05973 401 LHVKKRLSAHAYPRTIHFVDELPKTPSGKIQRFLLR 436
|
|
| MACS_euk |
cd05928 |
Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step ... |
72-556 |
6.76e-72 |
|
Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The acyl-CoA is a key intermediate in many important biosynthetic and catabolic processes. MACS enzymes are localized to mitochondria. Two murine MACS family proteins are found in liver and kidney. In rodents, a MACS member is detected particularly in the olfactory epithelium and is called O-MACS. O-MACS demonstrates substrate preference for the fatty acid lengths of C6-C12.
Pssm-ID: 341251 [Multi-domain] Cd Length: 530 Bit Score: 239.29 E-value: 6.76e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 72 GVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLICDAALEGEVvrEVIASieaegnA 151
Cdd:cd05928 63 GLQRGDRVAVILPRVPEWWLVNVACIRTGLVFIPGTIQLTAKDILYRLQASKAKCIVTSDELAPEV--DSVAS------E 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 152 APRVFTTRARALQTRDDPRVFgtqreasgagegaRDLLQAAQ----AVQPGrkpppvvlaASDPAMLVYTSGTSGRPKGA 227
Cdd:cd05928 135 CPSLKTKLLVSEKSRDGWLNF-------------KELLNEAStehhCVETG---------SQEPMAIYFTSGTTGSPKMA 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 228 ICTHGN----FAFNSQTYRDfcgLREGGPILGVAPLFHITGLVGHIGAAWIARAPLILTH--RFDPAATLDAIEEHRAEF 301
Cdd:cd05928 193 EHSHSSlglgLKVNGRYWLD---LTASDIMWNTSDTGWIKSAWSSLFEPWIQGACVFVHHlpRFDPLVILKTLSSYPITT 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 302 TIGAITVFIALLHHaDATREKLATLTKIYSGGAPIAPSVVEAFRAKFGHVIHGAYGLTETNSpTHMVPlaRTAPVDPHSg 381
Cdd:cd05928 270 FCGAPTVYRMLVQQ-DLSSYKFPSLQHCVTGGEPLNPEVLEKWKAQTGLDIYEGYGQTETGL-ICANF--KGMKIKPGS- 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 382 alaMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVP-----GYWNNAAATADAFRGGWFHTGDVGFMDEAGWFYLV 456
Cdd:cd05928 345 ---MGKASPPYDVQIIDDNGNVLPPGTEGDIGIRVKPIRPfglfsGYVDNPEKTAATIRGDFYLTGDRGIMDEDGYFWFM 421
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 457 DRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVADA-----AELIAFCKARMAAYK 531
Cdd:cd05928 422 GRADDVINSSGYRIGPFEVESALIEHPAVVESAVVSSPDPIRGEVVKAFVVLAPQFLSHDpeqltKELQQHVKSVTAPYK 501
|
490 500
....*....|....*....|....*
gi 1595048490 532 YPRIVEFRDELPKTATGKILRRELR 556
Cdd:cd05928 502 YPRKVEFVQELPKTVTGKIQRNELR 526
|
|
| BCL_like |
cd05919 |
Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; This family contains benzoate ... |
42-556 |
6.27e-71 |
|
Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; This family contains benzoate CoA ligase (BCL) and related ligases that catalyze the acylation of benzoate derivatives, 2-aminobenzoate and 4-hydroxybenzoate. Aromatic compounds represent the second most abundant class of organic carbon compounds after carbohydrates. Xenobiotic aromatic compounds are also a major class of man-made pollutants. Some bacteria use benzoate as the sole source of carbon and energy through benzoate degradation. Benzoate degradation starts with its activation to benzoyl-CoA by benzoate CoA ligase. The reaction catalyzed by benzoate CoA ligase proceeds via a two-step process; the first ATP-dependent step forms an acyl-AMP intermediate, and the second step forms the acyl-CoA ester with release of the AMP.
Pssm-ID: 341243 [Multi-domain] Cd Length: 436 Bit Score: 233.89 E-value: 6.27e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 42 ESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDD 121
Cdd:cd05919 1 KTAFYAADRSVTYGQLHDGANRLGSALRNLGVSSGDRVLLLMLDSPELVQLFLGCLARGAIAVVINPLLHPDDYAYIARD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 122 SQARVLICDAAlegevvreviasieaegnaaprvfttraralqtrddprvfgtqreasgagegardllqaaqavqpgrkp 201
Cdd:cd05919 81 CEARLVVTSAD--------------------------------------------------------------------- 91
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 202 ppvvlaasDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTY-RDFCGLREGGPILGVAPLFHITGLVGHIGAAWIARAPLI 280
Cdd:cd05919 92 --------DIAYLLYSSGTTGPPKGVMHAHRDPLLFADAMaREALGLTPGDRVFSSAKMFFGYGLGNSLWFPLAVGASAV 163
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 281 L-THRFDPAATLDAIEEHRAEFTIGAITVFIALLHHADATREKLATLTKIYSGGAPIAPSVVEAFRAKFGHVIHGAYGLT 359
Cdd:cd05919 164 LnPGWPTAERVLATLARFRPTVLYGVPTFYANLLDSCAGSPDALRSLRLCVSAGEALPRGLGERWMEHFGGPILDGIGAT 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 360 ETnspTHMVPLARTAPVDPHSgalaMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWNNAAATADAFRGGWF 439
Cdd:cd05919 244 EV---GHIFLSNRPGAWRLGS----TGRPVPGYEIRLVDEEGHTIPPGEEGDLLVRGPSAAVGYWNNPEKSRATFNGGWY 316
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 440 HTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVAD---A 516
Cdd:cd05919 317 RTGDKFCRDADGWYTHAGRADDMLKVGGQWVSPVEVESLIIQHPAVAEAAVVAVPESTGLSRLTAFVVLKSPAAPQeslA 396
|
490 500 510 520
....*....|....*....|....*....|....*....|
gi 1595048490 517 AELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:cd05919 397 RDIHRHLLERLSAHKVPRRIAFVDELPRTATGKLQRFKLR 436
|
|
| PLN02246 |
PLN02246 |
4-coumarate--CoA ligase |
61-556 |
1.54e-70 |
|
4-coumarate--CoA ligase
Pssm-ID: 215137 [Multi-domain] Cd Length: 537 Bit Score: 235.65 E-value: 1.54e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 61 SDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLICDAAlegevvre 140
Cdd:PLN02246 60 SRRVAAGLHKLGIRQGDVVMLLLPNCPEFVLAFLGASRRGAVTTTANPFYTPAEIAKQAKASGAKLIITQSC-------- 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 141 viasieaegnaaprvFTTRARALQTRDDPRVFGTQREASGAGEgARDLLQAAQAVqpgrkPPPVVLAASDPAMLVYTSGT 220
Cdd:PLN02246 132 ---------------YVDKLKGLAEDDGVTVVTIDDPPEGCLH-FSELTQADENE-----LPEVEISPDDVVALPYSSGT 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 221 SGRPKGAICTHGNFAF---------NSQTYrdfcgLREGGPILGVAPLFHITGLVGHIGAAWIARAPLILTHRFDPAATL 291
Cdd:PLN02246 191 TGLPKGVMLTHKGLVTsvaqqvdgeNPNLY-----FHSDDVILCVLPMFHIYSLNSVLLCGLRVGAAILIMPKFEIGALL 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 292 DAIEEHRAefTIGAIT--VFIALLHHADATREKLATLTKIYSGGAPIAPSVVEAFRAKFGHVIHG-AYGLTETNSPTHMV 368
Cdd:PLN02246 266 ELIQRHKV--TIAPFVppIVLAIAKSPVVEKYDLSSIRMVLSGAAPLGKELEDAFRAKLPNAVLGqGYGMTEAGPVLAMC 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 369 PLARTAPVDPHSGALamGVPVPGAEAAIVD-DDGNMLAAGETGEIVCRGPMVVPGYWNNAAATADAF-RGGWFHTGDVGF 446
Cdd:PLN02246 344 LAFAKEPFPVKSGSC--GTVVRNAELKIVDpETGASLPRNQPGEICIRGPQIMKGYLNDPEATANTIdKDGWLHTGDIGY 421
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 447 MDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVADAAELIAFCKAR 526
Cdd:PLN02246 422 IDDDDELFIVDRLKELIKYKGFQVAPAELEALLISHPSIADAAVVPMKDEVAGEVPVAFVVRSNGSEITEDEIKQFVAKQ 501
|
490 500 510
....*....|....*....|....*....|
gi 1595048490 527 MAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:PLN02246 502 VVFYKRIHKVFFVDSIPKAPSGKILRKDLR 531
|
|
| A_NRPS |
cd05930 |
The adenylation domain of nonribosomal peptide synthetases (NRPS); The adenylation (A) domain ... |
40-555 |
2.92e-70 |
|
The adenylation domain of nonribosomal peptide synthetases (NRPS); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341253 [Multi-domain] Cd Length: 444 Bit Score: 232.42 E-value: 2.92e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 40 PHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLL 119
Cdd:cd05930 1 PDAVAVVDGDQSLTYAELDARANRLARYLRERGVGPGDLVAVLLERSLEMVVAILAVLKAGAAYVPLDPSYPAERLAYIL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 120 DDSQARVLICDAalegevvreviasieaegnaaprvfttraralqtrddprvfgtqreasgagegardllqaaqavqpgr 199
Cdd:cd05930 81 EDSGAKLVLTDP-------------------------------------------------------------------- 92
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 200 kpppvvlaaSDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGlVGHIGAAWIARAPL 279
Cdd:cd05930 93 ---------DDLAYVIYTSGSTGKPKGVMVEHRGLVNLLLWMQEAYPLTPGDRVLQFTSFSFDVS-VWEIFGALLAGATL 162
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 280 IL---THRFDPAATLDAIEEHRAEFTIGAITVFIALLHHADATRekLATLTKIYSGGAPIAPSVVEAFRAKF-GHVIHGA 355
Cdd:cd05930 163 VVlpeEVRKDPEALADLLAEEGITVLHLTPSLLRLLLQELELAA--LPSLRLVLVGGEALPPDLVRRWRELLpGARLVNL 240
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 356 YGLTETnspTHMVPLARTAPVDPHSGALAMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWNNAAATADAFR 435
Cdd:cd05930 241 YGPTEA---TVDATYYRVPPDDEEDGRVPIGRPIPNTRVYVLDENLRPVPPGVPGELYIGGAGLARGYLNRPELTAERFV 317
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 436 GGWFH-------TGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSL 508
Cdd:cd05930 318 PNPFGpgermyrTGDLVRWLPDGNLEFLGRIDDQVKIRGYRIELGEIEAALLAHPGVREAAVVAREDGDGEKRLVAYVVP 397
|
490 500 510 520
....*....|....*....|....*....|....*....|....*..
gi 1595048490 509 RAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRREL 555
Cdd:cd05930 398 DEGGELDEEELRAHLAERLPDYMVPSAFVVLDALPLTPNGKVDRKAL 444
|
|
| Firefly_Luc |
cd17642 |
insect luciferase, similar to plant 4-coumarate: CoA ligases; This family contains insect ... |
61-556 |
5.46e-70 |
|
insect luciferase, similar to plant 4-coumarate: CoA ligases; This family contains insect firefly luciferases that share significant sequence similarity to plant 4-coumarate:coenzyme A ligases, despite their functional diversity. Luciferase catalyzes the production of light in the presence of MgATP, molecular oxygen, and luciferin. In the first step, luciferin is activated by acylation of its carboxylate group with ATP, resulting in an enzyme-bound luciferyl adenylate. In the second step, luciferyl adenylate reacts with molecular oxygen, producing an enzyme-bound excited state product (Luc=O*) and releasing AMP. This excited-state product then decays to the ground state (Luc=O), emitting a quantum of visible light.
Pssm-ID: 341297 [Multi-domain] Cd Length: 532 Bit Score: 234.34 E-value: 5.46e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 61 SDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLICDAAlegevvre 140
Cdd:cd17642 54 SVRLAEALKKYGLKQNDRIAVCSENSLQFFLPVIAGLFIGVGVAPTNDIYNERELDHSLNISKPTIVFCSKK-------- 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 141 viaSIEAEGNAAPRV-FTTRARALQTRDDPR------VFGTQReaSGAGEGARDLLqaaqavqpgrkpPPVVLAASDPAM 213
Cdd:cd17642 126 ---GLQKVLNVQKKLkIIKTIIILDSKEDYKgyqclyTFITQN--LPPGFNEYDFK------------PPSFDRDEQVAL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 214 LVYTSGTSGRPKGAICTHGNFAFNSQTYRD---FCGLREGGPILGVAPLFHITGLVGHIGAAwIARAPLILTHRFDPAAT 290
Cdd:cd17642 189 IMNSSGSTGLPKGVQLTHKNIVARFSHARDpifGNQIIPDTAILTVIPFHHGFGMFTTLGYL-ICGFRVVLMYKFEEELF 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 291 LDAIEEHRAEFTIGAITVFIALLHHADATREKLATLTKIYSGGAPIAPSVVEAFRAKFG-HVIHGAYGLTETNSPTHMVP 369
Cdd:cd17642 268 LRSLQDYKVQSALLVPTLFAFFAKSTLVDKYDLSNLHEIASGGAPLSKEVGEAVAKRFKlPGIRQGYGLTETTSAILITP 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 370 LARTAPVdphsgalAMGVPVPGAEAAIVD-DDGNMLAAGETGEIVCRGPMVVPGYWNNAAATADAF-RGGWFHTGDVGFM 447
Cdd:cd17642 348 EGDDKPG-------AVGKVVPFFYAKVVDlDTGKTLGPNERGELCVKGPMIMKGYVNNPEATKALIdKDGWLHSGDIAYY 420
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 448 DEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVADAAELIAFCKARM 527
Cdd:cd17642 421 DEDGHFFIVDRLKSLIKYKGYQVPPAELESILLQHPKIFDAGVAGIPDEDAGELPAAVVVLEAGKTMTEKEVMDYVASQV 500
|
490 500 510
....*....|....*....|....*....|
gi 1595048490 528 AAYKYPR-IVEFRDELPKTATGKILRRELR 556
Cdd:cd17642 501 STAKRLRgGVKFVDEVPKGLTGKIDRRKIR 530
|
|
| PRK07529 |
PRK07529 |
AMP-binding domain protein; Validated |
17-556 |
9.18e-70 |
|
AMP-binding domain protein; Validated
Pssm-ID: 236043 [Multi-domain] Cd Length: 632 Bit Score: 236.01 E-value: 9.18e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 17 IEPNPQQEY---TNGLDMFAAALERAPHESALLYFDG--------RLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQN 85
Cdd:PRK07529 13 IEAVPLAARdlpASTYELLSRAAARHPDAPALSFLLDadpldrpeTWTYAELLADVTRTANLLHSLGVGPGDVVAFLLPN 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 86 VPQFVMALLGIWKAGAVMvPVNPMNRARELKLLLDDSQARVLICDAALEG-EVVREVIASIEAEGNAAPRVFTTRARALQ 164
Cdd:PRK07529 93 LPETHFALWGGEAAGIAN-PINPLLEPEQIAELLRAAGAKVLVTLGPFPGtDIWQKVAEVLAALPELRTVVEVDLARYLP 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 165 TrddPRVFGTQREASGAGEGARDLLqAAQAVQPGRKP-PPVVLAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRD 243
Cdd:PRK07529 172 G---PKRLAVPLIRRKAHARILDFD-AELARQPGDRLfSGRPIGPDDVAAYFHTGGTTGMPKLAQHTHGNEVANAWLGAL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 244 FCGLREGGPILGVAPLFHITGLVGHIGAAWIARAPLILT----HRfDPAAT---LDAIEEHRAEFTIGAITVFIALLHH- 315
Cdd:PRK07529 248 LLGLGPGDTVFCGLPLFHVNALLVTGLAPLARGAHVVLAtpqgYR-GPGVIanfWKIVERYRINFLSGVPTVYAALLQVp 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 316 ADAtrEKLATLTKIYSGGAPIAPSVVEAFRAKFGHVIHGAYGLTETNSpthmvpLARTAPVDPHSGALAMGVPVPGAEAA 395
Cdd:PRK07529 327 VDG--HDISSLRYALCGAAPLPVEVFRRFEAATGVRIVEGYGLTEATC------VSSVNPPDGERRIGSVGLRLPYQRVR 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 396 IV--DDDGNML---AAGETGEIVCRGPMVVPGYWNNAAATADAFRGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKV 470
Cdd:PRK07529 399 VVilDDAGRYLrdcAVDEVGVLCIAGPNVFSGYLEAAHNKGLWLEDGWLNTGDLGRIDADGYFWLTGRAKDLIIRGGHNI 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 471 WPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVADAAELIAFCKARM---AAykYPRIVEFRDELPKTAT 547
Cdd:PRK07529 479 DPAAIEEALLRHPAVALAAAVGRPDAHAGELPVAYVQLKPGASATEAELLAFARDHIaerAA--VPKHVRILDALPKTAV 556
|
....*....
gi 1595048490 548 GKILRRELR 556
Cdd:PRK07529 557 GKIFKPALR 565
|
|
| PRK13382 |
PRK13382 |
bile acid CoA ligase; |
32-556 |
4.38e-69 |
|
bile acid CoA ligase;
Pssm-ID: 172019 [Multi-domain] Cd Length: 537 Bit Score: 231.96 E-value: 4.38e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 32 FAAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNR 111
Cdd:PRK13382 49 FAIAAQRCPDRPGLIDELGTLTWRELDERSDALAAALQALPIGEPRVVGIMCRNHRGFVEALLAANRIGADILLLNTSFA 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 112 ARELKLLLDDSQARVLICDaalegevvREVIASIeaegnaaPRVFTTRARALQTRDDPrvfgtqreaSGAGEGARDLLQA 191
Cdd:PRK13382 129 GPALAEVVTREGVDTVIYD--------EEFSATV-------DRALADCPQATRIVAWT---------DEDHDLTVEVLIA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 192 AQAvqpGRKPPPvvlAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLvGHIGA 271
Cdd:PRK13382 185 AHA---GQRPEP---TGRKGRVILLTSGTTGTPKGARRSGPGGIGTLKAILDRTPWRAEEPTVIVAPMFHAWGF-SQLVL 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 272 AWIARAPLILTHRFDPAATLDAIEEHRAEFTIGAITVFIALLHHADATREKLA--TLTKIYSGGAPIAPSVVEAFRAKFG 349
Cdd:PRK13382 258 AASLACTIVTRRRFDPEATLDLIDRHRATGLAVVPVMFDRIMDLPAEVRNRYSgrSLRFAAASGSRMRPDVVIAFMDQFG 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 350 HVIHGAYGLTEtnspthmVPLARTA-PVDPHSGALAMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYwnnAA 428
Cdd:PRK13382 338 DVIYNNYNATE-------AGMIATAtPADLRAAPDTAGRPAEGTEIRILDQDFREVPTGEVGTIFVRNDTQFDGY---TS 407
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 429 ATADAFRGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSL 508
Cdd:PRK13382 408 GSTKDFHDGFMASGDVGYLDENGRLFVVGRDDEMIVSGGENVYPIEVEKTLATHPDVAEAAVIGVDDEQYGQRLAAFVVL 487
|
490 500 510 520
....*....|....*....|....*....|....*....|....*...
gi 1595048490 509 RAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:PRK13382 488 KPGASATPETLKQHVRDNLANYKVPRDIVVLDELPRGATGKILRRELQ 535
|
|
| FACL_like_6 |
cd05922 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ... |
63-556 |
1.97e-68 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341246 [Multi-domain] Cd Length: 457 Bit Score: 228.09 E-value: 1.97e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 63 RIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGA----VMVPVNPMNRARELKLLLDDSQARVLICDAALEGEVv 138
Cdd:cd05922 5 AAASALLEAGGVRGERVVLILPNRFTYIELSFAVAYAGGrlglVFVPLNPTLKESVLRYLVADAGGRIVLADAGAADRL- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 139 reviasieaegnaaprvfttRARALQTRDDPRVFGTQREAsgageGARDLLQAaqavqpgrkpppVVLAASDPAMLVYTS 218
Cdd:cd05922 84 --------------------RDALPASPDPGTVLDADGIR-----AARASAPA------------HEVSHEDLALLLYTS 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 219 GTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLvGHIGAAWIARAPLILTHRFDPAATL-DAIEEH 297
Cdd:cd05922 127 GSTGSPKLVRLSHQNLLANARSIAEYLGITADDRALTVLPLSYDYGL-SVLNTHLLRGATLVLTNDGVLDDAFwEDLREH 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 298 RAEFTIGAITVFiALLHHADATREKLATLTKIYSGGAPIAPSVVEAFRAKF-GHVIHGAYGLTETNspthmvplARTAPV 376
Cdd:cd05922 206 GATGLAGVPSTY-AMLTRLGFDPAKLPSLRYLTQAGGRLPQETIARLRELLpGAQVYVMYGQTEAT--------RRMTYL 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 377 DPHSGAL---AMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWNNAAATADAFRGG-WFHTGDVGFMDEAGW 452
Cdd:cd05922 277 PPERILEkpgSIGLAIPGGEFEILDDDGTPTPPGEPGEIVHRGPNVMKGYWNDPPYRRKEGRGGgVLHTGDLARRDEDGF 356
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 453 FYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYrGETVKAVVSLRAGavADAAELIAFCKARMAAYKY 532
Cdd:cd05922 357 LFIVGRRDRMIKLFGNRISPTEIEAAARSIGLIIEAAAVGLPDPL-GEKLALFVTAPDK--IDPKDVLRSLAERLPPYKV 433
|
490 500
....*....|....*....|....
gi 1595048490 533 PRIVEFRDELPKTATGKILRRELR 556
Cdd:cd05922 434 PATVRVVDELPLTASGKVDYAALR 457
|
|
| PtmA |
cd17636 |
long-chain fatty acid CoA ligase (FadD); This family contains fatty acid CoA ligases, ... |
210-548 |
1.82e-67 |
|
long-chain fatty acid CoA ligase (FadD); This family contains fatty acid CoA ligases, including acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II, most of which are yet to be characterized. Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341291 [Multi-domain] Cd Length: 331 Bit Score: 221.41 E-value: 1.82e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 210 DPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLVG-----HIGAAwiarapLILTHR 284
Cdd:cd17636 1 DPVLAIYTAAFSGRPNGALLSHQALLAQALVLAVLQAIDEGTVFLNSGPLFHIGTLMFtlatfHAGGT------NVFVRR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 285 FDPAATLDAIEEHRAE--FTIGAItvfIALLHHADATRekLATLTKIYSG------GAPIAPSVVEAFRAKFGhvihgaY 356
Cdd:cd17636 75 VDAEEVLELIEAERCThaFLLPPT---IDQIVELNADG--LYDLSSLRSSpaapewNDMATVDTSPWGRKPGG------Y 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 357 GLTETNSPTHMVPLARtapvdphSGALAMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWNNAAATADAFRG 436
Cdd:cd17636 144 GQTEVMGLATFAALGG-------GAIGGAGRPSPLVQVRILDEDGREVPDGEVGEIVARGPTVMAGYWNRPEVNARRTRG 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 437 GWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVADA 516
Cdd:cd17636 217 GWHHTNDLGRREPDGSLSFVGPKTRMIKSGAENIYPAEVERCLRQHPAVADAAVIGVPDPRWAQSVKAIVVLKPGASVTE 296
|
330 340 350
....*....|....*....|....*....|..
gi 1595048490 517 AELIAFCKARMAAYKYPRIVEFRDELPKTATG 548
Cdd:cd17636 297 AELIEHCRARIASYKKPKSVEFADALPRTAGG 328
|
|
| CBAL |
cd05923 |
4-Chlorobenzoate-CoA ligase (CBAL); CBAL catalyzes the conversion of 4-chlorobenzoate (4-CB) ... |
30-555 |
6.01e-67 |
|
4-Chlorobenzoate-CoA ligase (CBAL); CBAL catalyzes the conversion of 4-chlorobenzoate (4-CB) to 4-chlorobenzoyl-coenzyme A (4-CB-CoA) by the two-step adenylation and thioester-forming reactions. 4-Chlorobenzoate (4-CBA) is an environmental pollutant derived from microbial breakdown of aromatic pollutants, such as polychlorinated biphenyls (PCBs), DDT, and certain herbicides. The 4-CBA degrading pathway converts 4-CBA to the metabolite 4-hydroxybezoate (4-HBA), allowing some soil-dwelling microbes to utilize 4-CBA as an alternate carbon source. This pathway consists of three chemical steps catalyzed by 4-CBA-CoA ligase, 4-CBA-CoA dehalogenase, and 4HBA-CoA thioesterase in sequential reactions.
Pssm-ID: 341247 [Multi-domain] Cd Length: 493 Bit Score: 225.08 E-value: 6.01e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 30 DMFAAALERAPHESALLYFDG--RLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVN 107
Cdd:cd05923 5 EMLRRAASRAPDACAIADPARglRLTYSELRARIEAVAARLHARGLRPGQRVAVVLPNSVEAVIALLALHRLGAVPALIN 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 108 PMNRARELKLLLD-DSQARVLICDAALegevvreviasieaegnAAPRVFTTRARALQTRDDPRvfgtqreaSGAGEGAR 186
Cdd:cd05923 85 PRLKAAELAELIErGEMTAAVIAVDAQ-----------------VMDAIFQSGVRVLALSDLVG--------LGEPESAG 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 187 DLLQAaqavqPGRKPppvvlaaSDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREG--GPILGVAPLFHITG 264
Cdd:cd05923 140 PLIED-----PPREP-------EQPAFVFYTSGTTGLPKGAVIPQRAAESRVLFMSTQAGLRHGrhNVVLGLMPLYHVIG 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 265 LVGHIGAAWIARAPLILTHRFDPAATLDAIEEHRAEFTIGAITVFIALLHHADATREKLATLTKIYSGGAPIAPSVVEAF 344
Cdd:cd05923 208 FFAVLVAALALDGTYVVVEEFDPADALKLIEQERVTSLFATPTHLDALAAAAEFAGLKLSSLRHVTFAGATMPDAVLERV 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 345 RAKFGHVIHGAYGLTETNSPTHMVPLARTAPVDPHSGALAMGVPVPGAEAAIvdddgnmLAAGETGEIVCR--GPMVVPG 422
Cdd:cd05923 288 NQHLPGEKVNIYGTTEAMNSLYMRDARTGTEMRPGFFSEVRIVRIGGSPDEA-------LANGEEGELIVAaaADAAFTG 360
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 423 YWNNAAATADAFRGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETV 502
Cdd:cd05923 361 YLNQPEATAKKLQDGWYRTGDVGYVDPSGDVRILGRVDDMIISGGENIHPSEIERVLSRHPGVTEVVVIGVADERWGQSV 440
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 1595048490 503 KAVVSLRAGAVAdAAELIAFCKA-RMAAYKYPRIVEFRDELPKTATGKILRREL 555
Cdd:cd05923 441 TACVVPREGTLS-ADELDQFCRAsELADFKRPRRYFFLDELPKNAMNKVLRRQL 493
|
|
| PRK05852 |
PRK05852 |
fatty acid--CoA ligase family protein; |
16-553 |
9.33e-67 |
|
fatty acid--CoA ligase family protein;
Pssm-ID: 235625 [Multi-domain] Cd Length: 534 Bit Score: 225.54 E-value: 9.33e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 16 GIEPNPQQEYTNGLDMFAAALERAPHESALLYFDGR--LDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMAL 93
Cdd:PRK05852 6 GAAPMASDFGPRIADLVEVAATRLPEAPALVVTADRiaISYRDLARLVDDLAGQLTRSGLLPGDRVALRMGSNAEFVVAL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 94 LGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLICDAALEGEvvreviasiEAEGNAAPRVFTTRAralqTRDDPRVFG 173
Cdd:PRK05852 86 LAASRADLVVVPLDPALPIAEQRVRSQAAGARVVLIDADGPHD---------RAEPTTRWWPLTVNV----GGDSGPSGG 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 174 T---QREASGAgegardlLQAAQAVQPGRKPppvvlaasDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREG 250
Cdd:PRK05852 153 TlsvHLDAATE-------PTPATSTPEGLRP--------DDAMIMFTGGTTGLPKMVPWTHANIASSVRAIITGYRLSPR 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 251 GPILGVAPLFHITGLVGHIGAAWIARAPLILTHR--FDPAATLDAIEEHRAEFTIGAITVFIALLHHAD--ATREKLATL 326
Cdd:PRK05852 218 DATVAVMPLYHGHGLIAALLATLASGGAVLLPARgrFSAHTFWDDIKAVGATWYTAVPTIHQILLERAAtePSGRKPAAL 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 327 TKIYSGGAPIAPSVVEAFRAKFGHVIHGAYGLTETnspTHMVPLARTAPVDPHSGALAMGVPVP---GAEAAIVDDDGNM 403
Cdd:PRK05852 298 RFIRSCSAPLTAETAQALQTEFAAPVVCAFGMTEA---THQVTTTQIEGIGQTENPVVSTGLVGrstGAQIRIVGSDGLP 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 404 LAAGETGEIVCRGPMVVPGYWNNAAATADAFRGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHP 483
Cdd:PRK05852 375 LPAGAVGEVWLRGTTVVRGYLGDPTITAANFTDGWLRTGDLGSLSAAGDLSIRGRIKELINRGGEKISPERVEGVLASHP 454
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 484 AVREAAVVGVPDPYRGETVKAVVSLRAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRR 553
Cdd:PRK05852 455 NVMEAAVFGVPDQLYGEAVAAVIVPRESAPPTAEELVQFCRERLAAFEIPASFQEASGLPHTAKGSLDRR 524
|
|
| PLN02330 |
PLN02330 |
4-coumarate--CoA ligase-like 1 |
63-556 |
7.20e-66 |
|
4-coumarate--CoA ligase-like 1
Pssm-ID: 215189 [Multi-domain] Cd Length: 546 Bit Score: 223.70 E-value: 7.20e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 63 RIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLICDAALEGEVvrevi 142
Cdd:PLN02330 67 RFAKALRSLGLRKGQVVVVVLPNVAEYGIVALGIMAAGGVFSGANPTALESEIKKQAEAAGAKLIVTNDTNYGKV----- 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 143 asieaEGNAAPRVfttraralqtrddprVFGTQREASGAGegARDLLQAAQavQPGRKPPPVVLAASDPAMLVYTSGTSG 222
Cdd:PLN02330 142 -----KGLGLPVI---------------VLGEEKIEGAVN--WKELLEAAD--RAGDTSDNEEILQTDLCALPFSSGTTG 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 223 RPKGAICTHGNFAFNSQTYRDFCGLREGGPI--LGVAPLFHITGLVGHIGAAWIARAPLILTHRFDPAATLDAIEEHRAE 300
Cdd:PLN02330 198 ISKGVMLTHRNLVANLCSSLFSVGPEMIGQVvtLGLIPFFHIYGITGICCATLRNKGKVVVMSRFELRTFLNALITQEVS 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 301 FTIGAITVFIALLHHA-----DATREKLATltkIYSGGAPIAPSVVEAFRAKFGHV-IHGAYGLTETNSPThmvpLARTA 374
Cdd:PLN02330 278 FAPIVPPIILNLVKNPiveefDLSKLKLQA---IMTAAAPLAPELLTAFEAKFPGVqVQEAYGLTEHSCIT----LTHGD 350
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 375 PVDPHSGAL--AMGVPVPGAEAAIVD-DDGNMLAAGETGEIVCRGPMVVPGYWNNAAATADAF-RGGWFHTGDVGFMDEA 450
Cdd:PLN02330 351 PEKGHGIAKknSVGFILPNLEVKFIDpDTGRSLPKNTPGELCVRSQCVMQGYYNNKEETDRTIdEDGWLHTGDIGYIDDD 430
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 451 GWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVADAAELIAFCKARMAAY 530
Cdd:PLN02330 431 GDIFIVDRIKELIKYKGFQVAPAELEAILLTHPSVEDAAVVPLPDEEAGEIPAACVVINPKAKESEEDILNFVAANVAHY 510
|
490 500
....*....|....*....|....*.
gi 1595048490 531 KYPRIVEFRDELPKTATGKILRRELR 556
Cdd:PLN02330 511 KKVRVVQFVDSIPKSLSGKIMRRLLK 536
|
|
| BACL_like |
cd05929 |
Bacterial Bile acid CoA ligases and similar proteins; Bile acid-Coenzyme A ligase catalyzes ... |
71-556 |
1.32e-65 |
|
Bacterial Bile acid CoA ligases and similar proteins; Bile acid-Coenzyme A ligase catalyzes the formation of bile acid-CoA conjugates in a two-step reaction: the formation of a bile acid-AMP molecule as an intermediate, followed by the formation of a bile acid-CoA. This ligase requires a bile acid with a free carboxyl group, ATP, Mg2+, and CoA for synthesis of the final bile acid-CoA conjugate. The bile acid-CoA ligation is believed to be the initial step in the bile acid 7alpha-dehydroxylation pathway in the intestinal bacterium Eubacterium sp.
Pssm-ID: 341252 [Multi-domain] Cd Length: 473 Bit Score: 221.10 E-value: 1.32e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 71 EGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPmnrarelKLLLDDSQARVLICDAALEgevvreviASIEAEGN 150
Cdd:cd05929 37 EGVWIADGVYIYLINSILTVFAAAAAWKCGACPAYKSS-------RAPRAEACAIIEIKAAALV--------CGLFTGGG 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 151 AAPRVfttraralqtRDDPRVfgtqreasgagegardllqaaqavqPGRKPPPVVLAASDPAMLVYTSGTSGRPKGAICT 230
Cdd:cd05929 102 ALDGL----------EDYEAA-------------------------EGGSPETPIEDEAAGWKMLYSGGTTGRPKGIKRG 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 231 HGNFAFNSQTYRDF---CGLREGGPILGVAPLFHITGLVGHIGAAwIARAPLILTHRFDPAATLDAIEEHRAEFTIGAIT 307
Cdd:cd05929 147 LPGGPPDNDTLMAAalgFGPGADSVYLSPAPLYHAAPFRWSMTAL-FMGGTLVLMEKFDPEEFLRLIERYRVTFAQFVPT 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 308 VFIALLHHADATREK--LATLTKIYSGGAPIAPSVVEAFRAKFGHVIHGAYGLTETNSPThmvpLARTAPVDPHSGALam 385
Cdd:cd05929 226 MFVRLLKLPEAVRNAydLSSLKRVIHAAAPCPPWVKEQWIDWGGPIIWEYYGGTEGQGLT----IINGEEWLTHPGSV-- 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 386 GVPVpGAEAAIVDDDGNMLAAGETGEIVCRGPmvvPG--YWNNAAATADAF-RGGWFHTGDVGFMDEAGWFYLVDRKKDM 462
Cdd:cd05929 300 GRAV-LGKVHILDEDGNEVPPGEIGEVYFANG---PGfeYTNDPEKTAAARnEGGWSTLGDVGYLDEDGYLYLTDRRSDM 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 463 INAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVAD---AAELIAFCKARMAAYKYPRIVEFR 539
Cdd:cd05929 376 IISGGVNIYPQEIENALIAHPKVLDAAVVGVPDEELGQRVHAVVQPAPGADAGtalAEELIAFLRDRLSRYKCPRSIEFV 455
|
490
....*....|....*..
gi 1595048490 540 DELPKTATGKILRRELR 556
Cdd:cd05929 456 AELPRDDTGKLYRRLLR 472
|
|
| PRK13390 |
PRK13390 |
acyl-CoA synthetase; Provisional |
39-556 |
1.78e-65 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 139538 [Multi-domain] Cd Length: 501 Bit Score: 221.42 E-value: 1.78e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 39 APHESALLYFDG--RLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELK 116
Cdd:PRK13390 10 APDRPAVIVAETgeQVSYRQLDDDSAALARVLYDAGLRTGDVVALLSDNSPEALVVLWAALRSGLYITAINHHLTAPEAD 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 117 LLLDDSQARVLICDAALEGEVVreviasiEAEGNAAPRVfttraralqtrddprVFGTQREASGAGEGArdlLQAAQavq 196
Cdd:PRK13390 90 YIVGDSGARVLVASAALDGLAA-------KVGADLPLRL---------------SFGGEIDGFGSFEAA---LAGAG--- 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 197 pgrkpPPVvlaASDP--AMLVYTSGTSGRPKG--------AICTHGNFAFnsQTYRDFCGLREGGPILGVAPLFHIT--- 263
Cdd:PRK13390 142 -----PRL---TEQPcgAVMLYSSGTTGFPKGiqpdlpgrDVDAPGDPIV--AIARAFYDISESDIYYSSAPIYHAAplr 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 264 --GLVGHIGAAwiarapLILTHRFDPAATLDAIEEHRAEFTIGAITVFIALLHHADATREK--LATLTKIYSGGAPIAPS 339
Cdd:PRK13390 212 wcSMVHALGGT------VVLAKRFDAQATLGHVERYRITVTQMVPTMFVRLLKLDADVRTRydVSSLRAVIHAAAPCPVD 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 340 VVEAFRAKFGHVIHGAYGLTETnsptHMVPLARTAPVDPHSGALAMGVPvpgAEAAIVDDDGNMLAAGETGEIVCRGPMV 419
Cdd:PRK13390 286 VKHAMIDWLGPIVYEYYSSTEA----HGMTFIDSPDWLAHPGSVGRSVL---GDLHICDDDGNELPAGRIGTVYFERDRL 358
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 420 VPGYWNNAAATADAFRGG---WFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDP 496
Cdd:PRK13390 359 PFRYLNDPEKTAAAQHPAhpfWTTVGDLGSVDEDGYLYLADRKSFMIISGGVNIYPQETENALTMHPAVHDVAVIGVPDP 438
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1595048490 497 YRGETVKAVVSLRAGAVAD---AAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:PRK13390 439 EMGEQVKAVIQLVEGIRGSdelARELIDYTRSRIAHYKAPRSVEFVDELPRTPTGKLVKGLLR 501
|
|
| VL_LC_FACS_like |
cd05907 |
Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA ... |
52-518 |
1.36e-64 |
|
Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; This family includes long-chain fatty acid (C12-C20) CoA synthetases and Bubblegum-like very long-chain (>C20) fatty acid CoA synthetases. FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Eukaryotes generally have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells. Drosophila melanogaster mutant bubblegum (BGM) have elevated levels of very-long-chain fatty acids (VLCFA) caused by a defective gene later named bubblegum. The human homolog (hsBG) of bubblegum has been characterized as a very long chain fatty acid CoA synthetase that functions specifically in the brain; hsBG may play a central role in brain VLCFA metabolism and myelinogenesis. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.
Pssm-ID: 341233 [Multi-domain] Cd Length: 452 Bit Score: 217.46 E-value: 1.36e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 52 LDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLICDA 131
Cdd:cd05907 6 ITWAEFAEEVRALAKGLIALGVEPGDRVAILSRNRPEWTIADLAILAIGAVPVPIYPTSSAEQIAYILNDSEAKALFVED 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 132 AlegevvreviasieaegnaaprvfttraralqtrddprvfgtqreasgagegardllqaaqavqpgrkpppvvlaaSDP 211
Cdd:cd05907 86 P----------------------------------------------------------------------------DDL 89
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 212 AMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLVGHIGAAWIARAplILTHRFDPAATL 291
Cdd:cd05907 90 ATIIYTSGTTGRPKGVMLSHRNILSNALALAERLPATEGDRHLSFLPLAHVFERRAGLYVPLLAGA--RIYFASSAETLL 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 292 DAIEEHRAEFTIGAITVF---IALLHHADATREK--------LATLTKIYSGGAPIAPSVVEAFRAkFGHVIHGAYGLTE 360
Cdd:cd05907 168 DDLSEVRPTVFLAVPRVWekvYAAIKVKAVPGLKrklfdlavGGRLRFAASGGAPLPAELLHFFRA-LGIPVYEGYGLTE 246
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 361 TNSPTHMVPlartaPVDPHSGALamGVPVPGAEAAIVDDdgnmlaagetGEIVCRGPMVVPGYWNNAAATADAF-RGGWF 439
Cdd:cd05907 247 TSAVVTLNP-----PGDNRIGTV--GKPLPGVEVRIADD----------GEILVRGPNVMLGYYKNPEATAEALdADGWL 309
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 440 HTGDVGFMDEAGWFYLVDRKKD-MINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYrgetVKAVVSLRAGAVADAAE 518
Cdd:cd05907 310 HTGDLGEIDEDGFLHITGRKKDlIITSGGKNISPEPIENALKASPLISQAVVIGDGRPF----LVALIVPDPEALEAWAE 385
|
|
| A_NRPS_Srf_like |
cd12117 |
The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis ... |
30-555 |
2.51e-63 |
|
The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and, in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the adenylation domain of the Bacillus subtilis termination module (Surfactin domain, SrfA-C) which recognizes a specific amino acid building block, which is then activated and transferred to the terminal thiol of the 4'-phosphopantetheine (Ppan) arm of the downstream peptidyl carrier protein (PCP) domain.
Pssm-ID: 341282 [Multi-domain] Cd Length: 483 Bit Score: 215.14 E-value: 2.51e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 30 DMFAAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPM 109
Cdd:cd12117 1 ELFEEQAARTPDAVAVVYGDRSLTYAELNERANRLARRLRAAGVGPGDVVGVLAERSPELVVALLAVLKAGAAYVPLDPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 110 NRARELKLLLDDSQARVLICDAALEGEVvreviasieaegnaaprvfttraralqtrDDPRVFGTQREASGAGEGArdll 189
Cdd:cd12117 81 LPAERLAFMLADAGAKVLLTDRSLAGRA-----------------------------GGLEVAVVIDEALDAGPAG---- 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 190 qaaqavqpgrkPPPVVLAASDPAMLVYTSGTSGRPKGAICTHGN---FAFNsqtyRDFCGLREGGPILGVAPL------F 260
Cdd:cd12117 128 -----------NPAVPVSPDDLAYVMYTSGSTGRPKGVAVTHRGvvrLVKN----TNYVTLGPDDRVLQTSPLafdastF 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 261 HITGlvghigaAWIARAPLILT---HRFDPAATLDAIEEHRAefTIGAITVfiALLHH-ADATREKLATLTKIYSGGAPI 336
Cdd:cd12117 193 EIWG-------ALLNGARLVLApkgTLLDPDALGALIAEEGV--TVLWLTA--ALFNQlADEDPECFAGLRELLTGGEVV 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 337 APSVVEAFRAKFG--HVIHGaYGLTE--TNSPTHMVPlartaPVDPHSGALAMGVPVPGAEAAIVDDDGNMLAAGETGEI 412
Cdd:cd12117 262 SPPHVRRVLAACPglRLVNG-YGPTEntTFTTSHVVT-----ELDEVAGSIPIGRPIANTRVYVLDEDGRPVPPGVPGEL 335
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 413 VCRGPMVVPGYWNNAAATA-----DAFRGG--WFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAV 485
Cdd:cd12117 336 YVGGDGLALGYLNRPALTAerfvaDPFGPGerLYRTGDLARWLPDGRLEFLGRIDDQVKIRGFRIELGEIEAALRAHPGV 415
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1595048490 486 REAAVVGVPD-PYRGETVKAVVslrAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRREL 555
Cdd:cd12117 416 REAVVVVREDaGGDKRLVAYVV---AEGALDAAELRAFLRERLPAYMVPAAFVVLDELPLTANGKVDRRAL 483
|
|
| A_NRPS_AB3403-like |
cd17646 |
Peptide Synthetase; The adenylation (A) domain of NRPS recognizes a specific amino acid or ... |
30-555 |
6.78e-63 |
|
Peptide Synthetase; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341301 [Multi-domain] Cd Length: 488 Bit Score: 214.06 E-value: 6.78e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 30 DMFAAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPM 109
Cdd:cd17646 2 ALVAEQAARTPDAPAVVDEGRTLTYRELDERANRLAHLLRARGVGPEDRVAVLLPRSADLVVALLAVLKAGAAYLPLDPG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 110 NRARELKLLLDDSQARVLICDAALEgevvreviasieaegnaaprvfttraralqtrddprvfgtqreASGAGEGARDLL 189
Cdd:cd17646 82 YPADRLAYMLADAGPAVVLTTADLA-------------------------------------------ARLPAGGDVALL 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 190 QAAQAVQPGRKPPPVVLAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPL-FHITglVGH 268
Cdd:cd17646 119 GDEALAAPPATPPLVPPRPDNLAYVIYTSGSTGRPKGVMVTHAGIVNRLLWMQDEYPLGPGDRVLQKTPLsFDVS--VWE 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 269 IGAAWIARAPLIL----THRfDPAATLDAIEEHR---AEFTIGAITVFIALlhhadATREKLATLTKIYSGGAPIAPSVV 341
Cdd:cd17646 197 LFWPLVAGARLVVarpgGHR-DPAYLAALIREHGvttCHFVPSMLRVFLAE-----PAAGSCASLRRVFCSGEALPPELA 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 342 EAFRAKFGHVIHGAYGLTETnspTHMVPLARTAPVDPhSGALAMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVP 421
Cdd:cd17646 271 ARFLALPGAELHNLYGPTEA---AIDVTHWPVRGPAE-TPSVPIGRPVPNTRLYVLDDALRPVPVGVPGELYLGGVQLAR 346
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 422 GYWNNAAATADAFRGGWF-------HTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVP 494
Cdd:cd17646 347 GYLGRPALTAERFVPDPFgpgsrmyRTGDLARWRPDGALEFLGRSDDQVKIRGFRVEPGEIEAALAAHPAVTHAVVVARA 426
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1595048490 495 DPYRGETVKAVVSLRAGAVA-DAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRREL 555
Cdd:cd17646 427 APAGAARLVGYVVPAAGAAGpDTAALRAHLAERLPEYMVPAAFVVLDALPLTANGKLDRAAL 488
|
|
| PRK07787 |
PRK07787 |
acyl-CoA synthetase; Validated |
31-556 |
1.34e-62 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236096 [Multi-domain] Cd Length: 471 Bit Score: 212.93 E-value: 1.34e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 31 MFAAALERAPHESALLYFDGR-LDWQALDAWSDRIAcllldEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPM 109
Cdd:PRK07787 4 LNPAAVAAAADIADAVRIGGRvLSRSDLAGAATAVA-----ERVAGARRVAVLATPTLATVLAVVGALIAGVPVVPVPPD 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 110 NRARELKLLLDDSQARVLICDAAlegevvreviasieAEGNAAPRV-FTTRARALQTRDDPrvfgtqreasgagegardl 188
Cdd:PRK07787 79 SGVAERRHILADSGAQAWLGPAP--------------DDPAGLPHVpVRLHARSWHRYPEP------------------- 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 189 lqaaqavqpgrkpppvvlAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLV-G 267
Cdd:PRK07787 126 ------------------DPDAPALIVYTSGTTGPPKGVVLSRRAIAADLDALAEAWQWTADDVLVHGLPLFHVHGLVlG 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 268 HIGAAWIArAPLILTHRFDPAATLDAIEEhRAEFTIGAITVFIALLHHADATReKLATLTKIYSGGAPIAPSVVEAFRAK 347
Cdd:PRK07787 188 VLGPLRIG-NRFVHTGRPTPEAYAQALSE-GGTLYFGVPTVWSRIAADPEAAR-ALRGARLLVSGSAALPVPVFDRLAAL 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 348 FGHVIHGAYGLTETnspthMVPLARTAPVDPHSGALamGVPVPGAEAAIVDDDGNMLAA-GET-GEIVCRGPMVVPGYWN 425
Cdd:PRK07787 265 TGHRPVERYGMTET-----LITLSTRADGERRPGWV--GLPLAGVETRLVDEDGGPVPHdGETvGELQVRGPTLFDGYLN 337
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 426 NAAATADAFRG-GWFHTGDVGFMDEAGWFYLVDRKK-DMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVK 503
Cdd:PRK07787 338 RPDATAAAFTAdGWFRTGDVAVVDPDGMHRIVGREStDLIKSGGYRIGAGEIETALLGHPGVREAAVVGVPDDDLGQRIV 417
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|...
gi 1595048490 504 AVVSlrAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:PRK07787 418 AYVV--GADDVAADELIDFVAQQLSVHKRPREVRFVDALPRNAMGKVLKKQLL 468
|
|
| DltA |
cd05945 |
D-alanine:D-alanyl carrier protein ligase (DltA) and similar proteins; This family includes ... |
36-555 |
1.19e-61 |
|
D-alanine:D-alanyl carrier protein ligase (DltA) and similar proteins; This family includes D-alanyl carrier protein ligase DltA and aliphatic beta-amino acid adenylation enzymes IdnL1 and CmiS6. DltA incorporates D-ala in techoic acids in gram-positive bacteria via a two-step process, starting with adenylation of D-alanine that transfers D-alanine to the D-alanyl carrier protein. IdnL1, a short-chain aliphatic beta-amino acid adenylation enzyme, recognizes 3-aminobutanoic acid, and is involved in the synthesis of the macrolactam antibiotic incednine. CmiS6 is a medium-chain beta-amino acid adenylation enzyme that recognizes 3-aminononanoic acid, and is involved in the synthesis of cremimycin, also a macrolactam antibiotic. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341267 [Multi-domain] Cd Length: 449 Bit Score: 209.80 E-value: 1.19e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 36 LERAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVN---PMNRA 112
Cdd:cd05945 1 AAANPDRPAVVEGGRTLTYRELKERADALAAALASLGLDAGDPVVVYGHKSPDAIAAFLAALKAGHAYVPLDassPAERI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 113 RElklllddsqarvlICDAAlegevvreviasieaegnaaprvfttraralqtrddprvfgtqreasgagegardllqaa 192
Cdd:cd05945 81 RE-------------ILDAA------------------------------------------------------------ 87
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 193 qavqpgrKPPPVVLAASDPAMLVYTSGTSGRPKGAICTHGNF-AFNSQTYRDFcgLREGGPILGVAPLFHITGLVGHIGA 271
Cdd:cd05945 88 -------KPALLIADGDDNAYIIFTSGSTGRPKGVQISHDNLvSFTNWMLSDF--PLGPGDVFLNQAPFSFDLSVMDLYP 158
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 272 AWIARAPLILTHR---FDPAATLDAIEEHraeftigAITV------FIA-LLHHADATREKLATLTKIYSGGAPIAPSVV 341
Cdd:cd05945 159 ALASGATLVPVPRdatADPKQLFRFLAEH-------GITVwvstpsFAAmCLLSPTFTPESLPSLRHFLFCGEVLPHKTA 231
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 342 EAFRAKF-GHVIHGAYGLTETN---SPTHMvplarTAPVDPHSGALAMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGP 417
Cdd:cd05945 232 RALQQRFpDARIYNTYGPTEATvavTYIEV-----TPEVLDGYDRLPIGYAKPGAKLVILDEDGRPVPPGEKGELVISGP 306
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 418 MVVPGYWNNAAATADAFR----GGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGV 493
Cdd:cd05945 307 SVSKGYLNNPEKTAAAFFpdegQRAYRTGDLVRLEADGLLFYRGRLDFQVKLNGYRIELEEIEAALRQVPGVKEAVVVPK 386
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1595048490 494 PDpyrGETVK---AVVSLRAGAVA-DAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRREL 555
Cdd:cd05945 387 YK---GEKVTeliAFVVPKPGAEAgLTKAIKAELAERLPPYMIPRRFVYLDELPLNANGKIDRKAL 449
|
|
| 23DHB-AMP_lg |
cd05920 |
2,3-dihydroxybenzoate-AMP ligase; 2,3-dihydroxybenzoate-AMP ligase activates 2, ... |
30-555 |
2.93e-61 |
|
2,3-dihydroxybenzoate-AMP ligase; 2,3-dihydroxybenzoate-AMP ligase activates 2,3-dihydroxybenzoate (DHB) by ligation of AMP from ATP with the release of pyrophosphate. However, it can also catalyze the ATP-PPi exchange for 2,3-DHB analogs, such as salicyclic acid (o-hydrobenzoate), as well as 2,4-DHB and 2,5-DHB, but with less efficiency. Proteins in this family are the stand-alone adenylation components of non-ribosomal peptide synthases (NRPSs) involved in the biosynthesis of siderophores, which are low molecular weight iron-chelating compounds synthesized by many bacteria to aid in the acquisition of this vital trace elements. In Escherichia coli, the 2,3-dihydroxybenzoate-AMP ligase is called EntE, the adenylation component of the enterobactin NRPS system.
Pssm-ID: 341244 [Multi-domain] Cd Length: 482 Bit Score: 209.49 E-value: 2.93e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 30 DMFAAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPM 109
Cdd:cd05920 19 DLLARSAARHPDRIAVVDGDRRLTYRELDRRADRLAAGLRGLGIRPGDRVVVQLPNVAEFVVLFFALLRLGAVPVLALPS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 110 NRARELklllddsqarvlicdaalegevvREVIASIEAEGNAAPRVFTtraralqtRDDPRvfgtqreasgagEGARDLL 189
Cdd:cd05920 99 HRRSEL-----------------------SAFCAHAEAVAYIVPDRHA--------GFDHR------------ALARELA 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 190 QAaqavQPgrkpppvvlaasDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLV--G 267
Cdd:cd05920 136 ES----IP------------EVALFLLSGGTTGTPKLIPRTHNDYAYNVRASAEVCGLDQDTVYLAVLPAAHNFPLAcpG 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 268 HIGAAWiARAPLILTHRFDPAATLDAIEEHRAEFTIGAITVFIALLHHADATREKLATLTKIYSGGAPIAPSVVEAFRAK 347
Cdd:cd05920 200 VLGTLL-AGGRVVLAPDPSPDAAFPLIEREGVTVTALVPALVSLWLDAAASRRADLSSLRLLQVGGARLSPALARRVPPV 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 348 FGHVIHGAYGLTETnspthmvPLARTAPVDPHSGALA-MGVPV-PGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWN 425
Cdd:cd05920 279 LGCTLQQVFGMAEG-------LLNYTRLDDPDEVIIHtQGRPMsPDDEIRVVDEEGNPVPPGEEGELLTRGPYTIRGYYR 351
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 426 NAAATADAFRG-GWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKA 504
Cdd:cd05920 352 APEHNARAFTPdGFYRTGDLVRRTPDGYLVVEGRIKDQINRGGEKIAAEEVENLLLRHPAVHDAAVVAMPDELLGERSCA 431
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|..
gi 1595048490 505 VVSLRAGAVaDAAELIAFCKAR-MAAYKYPRIVEFRDELPKTATGKILRREL 555
Cdd:cd05920 432 FVVLRDPPP-SAAQLRRFLRERgLAAYKLPDRIEFVDSLPLTAVGKIDKKAL 482
|
|
| PrpE |
cd05967 |
Propionyl-CoA synthetase (PrpE); EC 6.2.1.17: propanoate:CoA ligase (AMP-forming) or ... |
41-556 |
3.56e-60 |
|
Propionyl-CoA synthetase (PrpE); EC 6.2.1.17: propanoate:CoA ligase (AMP-forming) or propionate#CoA ligase (PrpE) catalyzes the first step of the 2-methylcitric acid cycle for propionate catabolism. It activates propionate to propionyl-CoA in a two-step reaction, which proceeds through a propionyl-AMP intermediate and requires ATP and Mg2+. In Salmonella enterica, the PrpE protein is required for growth of Salmonella enterica on propionate and can substitute for the acetyl-CoA synthetase (Acs) enzyme during growth on acetate. PrpE can also activate acetate, 3HP, and butyrate to their corresponding CoA-thioesters, although with less efficiency.
Pssm-ID: 341271 [Multi-domain] Cd Length: 617 Bit Score: 209.86 E-value: 3.56e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 41 HESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLD 120
Cdd:cd05967 72 YDSPVTGTERTYTYAELLDEVSRLAGVLRKLGVVKGDRVIIYMPMIPEAAIAMLACARIGAIHSVVFGGFAAKELASRID 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 121 DSQARVLI-CDAALEGEVVREVIASIEaegnaaprvfttRARALQTRDDPRVFGTQRE--ASGAGEGARDLLQAAQAVQP 197
Cdd:cd05967 152 DAKPKLIVtASCGIEPGKVVPYKPLLD------------KALELSGHKPHHVLVLNRPqvPADLTKPGRDLDWSELLAKA 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 198 GRKPPpVVLAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQ-TYRDFCGLREGGPILGVAplfHITGLVGHigaAWIAR 276
Cdd:cd05967 220 EPVDC-VPVAATDPLYILYTSGTTGKPKGVVRDNGGHAVALNwSMRNIYGIKPGDVWWAAS---DVGWVVGH---SYIVY 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 277 APLIL-----------THRFDPAATLDAIEEHRAEFTIGAITVFIAL----LHHADATREKLATLTKIYSGGAPIAPSVV 341
Cdd:cd05967 293 GPLLHgattvlyegkpVGTPDPGAFWRVIEKYQVNALFTAPTAIRAIrkedPDGKYIKKYDLSSLRTLFLAGERLDPPTL 372
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 342 EAFRAKFGHVIHGAYGLTETNSPThMVPLARTAPVDPHSGAlaMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPM--- 418
Cdd:cd05967 373 EWAENTLGVPVIDHWWQTETGWPI-TANPVGLEPLPIKAGS--PGKPVPGYQVQVLDEDGEPVGPNELGNIVIKLPLppg 449
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 419 VVPGYWNNAAATADAFRG---GWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPD 495
Cdd:cd05967 450 CLLTLWKNDERFKKLYLSkfpGYYDTGDAGYKDEDGYLFIMGRTDDVINVAGHRLSTGEMEESVLSHPAVAECAVVGVRD 529
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1595048490 496 PYRGETVKAVVSLRAGAVADAA----ELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:cd05967 530 ELKGQVPLGLVVLKEGVKITAEelekELVALVREQIGPVAAFRLVIFVKRLPKTRSGKILRRTLR 594
|
|
| AA-adenyl-dom |
TIGR01733 |
amino acid adenylation domain; This model represents a domain responsible for the specific ... |
57-490 |
8.27e-59 |
|
amino acid adenylation domain; This model represents a domain responsible for the specific recognition of amino acids and activation as adenylyl amino acids. The reaction catalyzed is aa + ATP -> aa-AMP + PPi. These domains are usually found as components of multi-domain non-ribosomal peptide synthetases and are usually called "A-domains" in that context. A-domains are almost invariably followed by "T-domains" (thiolation domains, pfam00550) to which the amino acid adenylate is transferred as a thiol-ester to a bound pantetheine cofactor with the release of AMP (these are also called peptide carrier proteins, or PCPs. When the A-domain does not represent the first module (corresponding to the first amino acid in the product molecule) it is usually preceded by a "C-domain" (condensation domain, pfam00668) which catalyzes the ligation of two amino acid thiol-esters from neighboring modules. This domain is a subset of the AMP-binding domain found in Pfam (pfam00501) which also hits substrate--CoA ligases and luciferases. Sequences scoring in between trusted and noise for this model may be ambiguous as to whether they activate amino acids or other molecules lacking an alpha amino group.
Pssm-ID: 273779 [Multi-domain] Cd Length: 409 Bit Score: 200.95 E-value: 8.27e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 57 LDAWSDRIA-CLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLICDAALEG 135
Cdd:TIGR01733 5 LDERANRLArHLRAAGGVGPGDRVAVLLERSAELVVAILAVLKAGAAYVPLDPAYPAERLAFILEDAGARLLLTDSALAS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 136 EVVREVIASIEAEGnaaprvfttraralqtrddprvfgtqreasgagegaRDLLQAAQAVQPgrKPPPVVLAASDPAMLV 215
Cdd:TIGR01733 85 RLAGLVLPVILLDP------------------------------------LELAALDDAPAP--PPPDAPSGPDDLAYVI 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 216 YTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLfHITGLVGHIGAAWIARAPLILTHRFDPAATLDAIE 295
Cdd:TIGR01733 127 YTSGSTGRPKGVVVTHRSLVNLLAWLARRYGLDPDDRVLQFASL-SFDASVEEIFGALLAGATLVVPPEDEERDDAALLA 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 296 EHRAEFTIGAITVFIALLHH-ADATREKLATLTKIYSGGAPIAPSVVEAFRAKFGHV-IHGAYGLTETNSPTHMVPLARt 373
Cdd:TIGR01733 206 ALIAEHPVTVLNLTPSLLALlAAALPPALASLRLVILGGEALTPALVDRWRARGPGArLINLYGPTETTVWSTATLVDP- 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 374 aPVDPHSGALAMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWNNAAATADAF---------RGGWFHTGDV 444
Cdd:TIGR01733 285 -DDAPRESPVPIGRPLANTRLYVLDDDLRPVPVGVVGELYIGGPGVARGYLNRPELTAERFvpdpfaggdGARLYRTGDL 363
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 1595048490 445 GFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAV 490
Cdd:TIGR01733 364 VRYLPDGNLEFLGRIDDQVKIRGYRIELGEIEAALLRHPGVREAVV 409
|
|
| FAAL |
cd05931 |
Fatty acyl-AMP ligase (FAAL); FAAL belongs to the class I adenylate forming enzyme family and ... |
37-556 |
9.55e-59 |
|
Fatty acyl-AMP ligase (FAAL); FAAL belongs to the class I adenylate forming enzyme family and is homologous to fatty acyl-coenzyme A (CoA) ligases (FACLs). However, FAALs produce only the acyl adenylate and are unable to perform the thioester-forming reaction, while FACLs perform a two-step catalytic reaction; AMP ligation followed by CoA ligation using ATP and CoA as cofactors. FAALs have insertion motifs between the N-terminal and C-terminal subdomains that distinguish them from the FACLs. This insertion motif precludes the binding of CoA, thus preventing CoA ligation. It has been suggested that the acyl adenylates serve as substrates for multifunctional polyketide synthases to permit synthesis of complex lipids such as phthiocerol dimycocerosate, sulfolipids, mycolic acids, and mycobactin.
Pssm-ID: 341254 [Multi-domain] Cd Length: 547 Bit Score: 204.39 E-value: 9.55e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 37 ERAPHESALLYFDG------RLDWQALDAWSDRIACLLLDEGvQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMN 110
Cdd:cd05931 4 AARPDRPAYTFLDDeggreeTLTYAELDRRARAIAARLQAVG-KPGDRVLLLAPPGLDFVAAFLGCLYAGAIAVPLPPPT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 111 RARE---LKLLLDDSQARVLICDAALEGEVVREVIAsieAEGNAAPRVFTTRARALQTRDDPrvfgtqreasgagegard 187
Cdd:cd05931 83 PGRHaerLAAILADAGPRVVLTTAAALAAVRAFAAS---RPAAGTPRLLVVDLLPDTSAADW------------------ 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 188 llqaaqavqpgrkpPPVVLAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLVG 267
Cdd:cd05931 142 --------------PPPSPDPDDIAYLQYTSGSTGTPKGVVVTHRNLLANVRQIRRAYGLDPGDVVVSWLPLYHDMGLIG 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 268 HIGAAWIARAPLILT--HRF--DPAATLDAIEEHRAefTIGAITVFiALLHHADATREK------LATLTKIYSGGAPIA 337
Cdd:cd05931 208 GLLTPLYSGGPSVLMspAAFlrRPLRWLRLISRYRA--TISAAPNF-AYDLCVRRVRDEdlegldLSSWRVALNGAEPVR 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 338 PSVVEAFRAKFG------HVIHGAYGLTE-----TNSPTHMVP------------LARTAPVDPHSGA--LAMGVPVPGA 392
Cdd:cd05931 285 PATLRRFAEAFApfgfrpEAFRPSYGLAEatlfvSGGPPGTGPvvlrvdrdalagRAVAVAADDPAARelVSCGRPLPDQ 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 393 EAAIVDDDGNM-LAAGETGEIVCRGPMVVPGYWNNAAATADAFR-------GGWFHTGDVGFMDEaGWFYLVDRKKDMIN 464
Cdd:cd05931 365 EVRIVDPETGReLPDGEVGEIWVRGPSVASGYWGRPEATAETFGalaatdeGGWLRTGDLGFLHD-GELYITGRLKDLII 443
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 465 AAGYKVWPREVEDVLYG-HPAVRE--AAVVGVPDPYRGETVKAVVSLRAGAVADAAELIAFCKARMAAYK--YPRIVEF- 538
Cdd:cd05931 444 VRGRNHYPQDIEATAEEaHPALRPgcVAAFSVPDDGEERLVVVAEVERGADPADLAAIAAAIRAAVAREHgvAPADVVLv 523
|
570
....*....|....*....
gi 1595048490 539 -RDELPKTATGKILRRELR 556
Cdd:cd05931 524 rPGSIPRTSSGKIQRRACR 542
|
|
| ACS-like |
cd17634 |
acetate-CoA ligase; This family includes acyl- and aryl-CoA ligases, as well as the ... |
36-551 |
3.03e-58 |
|
acetate-CoA ligase; This family includes acyl- and aryl-CoA ligases, as well as the adenylation domain of nonribosomal peptide synthetases and firefly luciferases. The adenylate-forming enzymes catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain.
Pssm-ID: 341289 [Multi-domain] Cd Length: 587 Bit Score: 203.96 E-value: 3.03e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 36 LERAPHESALLYfDG-------RLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNP 108
Cdd:cd17634 63 LRENGDRTAIIY-EGddtsqsrTISYRELHREVCRFAGTLLDLGVKKGDRVAIYMPMIPEAAVAMLACARIGAVHSVIFG 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 109 MNRARELKLLLDDSQARVLI-CDAALE-GEVVREVIASIEAEGNAAPRVFTtraralqtrddprVFGTQREASG-AGEGA 185
Cdd:cd17634 142 GFAPEAVAGRIIDSSSRLLItADGGVRaGRSVPLKKNVDDALNPNVTSVEH-------------VIVLKRTGSDiDWQEG 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 186 RDLLQAAQAVQPGRKPPPVVLAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTyrDFCGLREGGPilgvAPLFHITGL 265
Cdd:cd17634 209 RDLWWRDLIAKASPEHQPEAMNAEDPLFILYTSGTTGKPKGVLHTTGGYLVYAAT--TMKYVFDYGP----GDIYWCTAD 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 266 VGHI-GAAWIARAPLIL---THRFD-------PAATLDAIEEHRAEFTIGAITVFIALLHHADATREK--LATLTKIYSG 332
Cdd:cd17634 283 VGWVtGHSYLLYGPLACgatTLLYEgvpnwptPARMWQVVDKHGVNILYTAPTAIRALMAAGDDAIEGtdRSSLRILGSV 362
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 333 GAPIAPSVVEAFRAKFGH----VIHGAYGlTETNSptHMVPLARTAPVDPHSGALamgVPVPGAEAAIVDDDGNMLAAGE 408
Cdd:cd17634 363 GEPINPEAYEWYWKKIGKekcpVVDTWWQ-TETGG--FMITPLPGAIELKAGSAT---RPVFGVQPAVVDNEGHPQPGGT 436
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 409 TGEIVCRGP---MVVPGYWNNA---AATADAFRGGWFHtGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGH 482
Cdd:cd17634 437 EGNLVITDPwpgQTRTLFGDHErfeQTYFSTFKGMYFS-GDGARRDEDGYYWITGRSDDVINVAGHRLGTAEIESVLVAH 515
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1595048490 483 PAVREAAVVGVPDPYRGETVKAVVSLRAGAVAD---AAELIAFCKARMAAYKYPRIVEFRDELPKTATGKIL 551
Cdd:cd17634 516 PKVAEAAVVGIPHAIKGQAPYAYVVLNHGVEPSpelYAELRNWVRKEIGPLATPDVVHWVDSLPKTRSGKIM 587
|
|
| A_NRPS_VisG_like |
cd17651 |
similar to adenylation domain of virginiamycin S synthetase; This family of the adenylation (A) ... |
32-556 |
1.36e-57 |
|
similar to adenylation domain of virginiamycin S synthetase; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes virginiamycin S synthetase (VisG) in Streptomyces virginiae; VisG is involved in virginiamycin S (VS) biosynthesis as the provider of an L-pheGly molecule, a highly specific substrate for the last condensation step by VisF. This family also includes linear gramicidin synthetase B (LgrB) in Brevibacillus brevis. Substrate specificity analysis using residues of the substrate-binding pockets of all 16 adenylation domains has shown good agreement of the substrate amino acids predicted with the sequence of linear gramicidin. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341306 [Multi-domain] Cd Length: 491 Bit Score: 199.88 E-value: 1.36e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 32 FAAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNR 111
Cdd:cd17651 1 FERQAARTPDAPALVAEGRRLTYAELDRRANRLAHRLRARGVGPGDLVALCARRSAELVVALLAILKAGAAYVPLDPAYP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 112 ARELKLLLDDSQARVLICDAALEGEVvreviasieaegnaaprvfttraralqtrDDPRVFGTqreasgagegardLLQA 191
Cdd:cd17651 81 AERLAFMLADAGPVLVLTHPALAGEL-----------------------------AVELVAVT-------------LLDQ 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 192 AQAVQPGRKPPPVVLAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPL-----FH-ITGL 265
Cdd:cd17651 119 PGAAAGADAEPDPALDADDLAYVIYTSGSTGRPKGVVMPHRSLANLVAWQARASSLGPGARTLQFAGLgfdvsVQeIFST 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 266 VGHIGAAWIARAPLilthRFDPAATLDAIEEHRAEFTIGAITVFIALLHHADATREKLATLTKIYSGG--APIAPSVVEA 343
Cdd:cd17651 199 LCAGATLVLPPEEV----RTDPPALAAWLDEQRISRVFLPTVALRALAEHGRPLGVRLAALRYLLTGGeqLVLTEDLREF 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 344 FRAKFGHVIHGAYGLTETNSPT-HMVPlartAPVDPHSGALAMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPG 422
Cdd:cd17651 275 CAGLPGLRLHNHYGPTETHVVTaLSLP----GDPAAWPAPPPIGRPIDNTRVYVLDAALRPVPPGVPGELYIGGAGLARG 350
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 423 YWNNAAATA-----DAFRGG--WFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPD 495
Cdd:cd17651 351 YLNRPELTAerfvpDPFVPGarMYRTGDLARWLPDGELEFLGRADDQVKIRGFRIELGEIEAALARHPGVREAVVLARED 430
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1595048490 496 PYRGETVKAVVSLRAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:cd17651 431 RPGEKRLVAYVVGDPEAPVDAAELRAALATHLPEYMVPSAFVLLDALPLTPNGKLDRRALP 491
|
|
| PLN02479 |
PLN02479 |
acetate-CoA ligase |
36-556 |
2.47e-56 |
|
acetate-CoA ligase
Pssm-ID: 178097 [Multi-domain] Cd Length: 567 Bit Score: 198.53 E-value: 2.47e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 36 LERA----PHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNR 111
Cdd:PLN02479 26 LERAavvhPTRKSVVHGSVRYTWAQTYQRCRRLASALAKRSIGPGSTVAVIAPNIPAMYEAHFGVPMAGAVVNCVNIRLN 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 112 ARELKLLLDDSQARVLICDA---ALEGEVVRevIASIEAEGNAAPRVFTTRAralQTRDDPRVFgtqreASGAGEGARDL 188
Cdd:PLN02479 106 APTIAFLLEHSKSEVVMVDQeffTLAEEALK--ILAEKKKSSFKPPLLIVIG---DPTCDPKSL-----QYALGKGAIEY 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 189 LQAAQAVQP--GRKPPPvvlAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLV 266
Cdd:PLN02479 176 EKFLETGDPefAWKPPA---DEWQSIALGYTSGTTASPKGVVLHHRGAYLMALSNALIWGMNEGAVYLWTLPMFHCNGWC 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 267 GHIGAAWIARAPLILTHrFDPAATLDAIEEHRAEFTIGAITVFIALLHH-ADATREKLATLTKIYSGGAPIAPSVVEAFR 345
Cdd:PLN02479 253 FTWTLAALCGTNICLRQ-VTAKAIYSAIANYGVTHFCAAPVVLNTIVNApKSETILPLPRVVHVMTAGAAPPPSVLFAMS 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 346 AKFGHVIHgAYGLTETNSPTHMV---PLARTAPVDPHSGALA-MGVPVPGAEAAIVDDDGNML---AAGET-GEIVCRGP 417
Cdd:PLN02479 332 EKGFRVTH-TYGLSETYGPSTVCawkPEWDSLPPEEQARLNArQGVRYIGLEGLDVVDTKTMKpvpADGKTmGEIVMRGN 410
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 418 MVVPGYWNNAAATADAFRGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPY 497
Cdd:PLN02479 411 MVMKGYLKNPKANEEAFANGWFHSGDLGVKHPDGYIEIKDRSKDIIISGGENISSLEVENVVYTHPAVLEASVVARPDER 490
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1595048490 498 RGETVKAVVSLRAGA-----VADAAELIAFCKARMAAYKYPRIVEFrDELPKTATGKILRRELR 556
Cdd:PLN02479 491 WGESPCAFVTLKPGVdksdeAALAEDIMKFCRERLPAYWVPKSVVF-GPLPKTATGKIQKHVLR 553
|
|
| MACS_like_1 |
cd05974 |
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ... |
52-556 |
1.13e-55 |
|
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. MACS enzymes are localized to mitochondria.
Pssm-ID: 341278 [Multi-domain] Cd Length: 432 Bit Score: 193.55 E-value: 1.13e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 52 LDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQArvlicda 131
Cdd:cd05974 1 VSFAEMSARSSRVANFLRSIGVGRGDRILLMLGNVVELWEAMLAAMKLGAVVIPATTLLTPDDLRDRVDRGGA------- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 132 alegevvreviasieaegnaaprvftTRARALQTRddprvfgtqreasgagegardllqaaqavqpgrkpppvvlAASDP 211
Cdd:cd05974 74 --------------------------VYAAVDENT----------------------------------------HADDP 87
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 212 AMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPlfhiTGLVGH----IGAAWIARAPLILTH--RF 285
Cdd:cd05974 88 MLLYFTSGTTSKPKLVEHTHRSYPVGHLSTMYWIGLKPGDVHWNISS----PGWAKHawscFFAPWNAGATVFLFNyaRF 163
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 286 DPAATLDAIEEHRAEFTIGAITVFiALLHHADATREKLAtLTKIYSGGAPIAPSVVEAFRAKFGHVIHGAYGLTET---- 361
Cdd:cd05974 164 DAKRVLAALVRYGVTTLCAPPTVW-RMLIQQDLASFDVK-LREVVGAGEPLNPEVIEQVRRAWGLTIRDGYGQTETtalv 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 362 -NSPTHmvplartaPVDPHSgalaMGVPVPGAEAAIVDDDGNMLAAGETGEIV--CRGPMVVPGYWNNAAATADAFRGGW 438
Cdd:cd05974 242 gNSPGQ--------PVKAGS----MGRPLPGYRVALLDPDGAPATEGEVALDLgdTRPVGLMKGYAGDPDKTAHAMRGGY 309
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 439 FHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGA---VAD 515
Cdd:cd05974 310 YRTGDIAMRDEDGYLTYVGRADDVFKSSDYRISPFELESVLIEHPAVAEAAVVPSPDPVRLSVPKAFIVLRAGYepsPET 389
|
490 500 510 520
....*....|....*....|....*....|....*....|.
gi 1595048490 516 AAELIAFCKARMAAYKYPRIVEFRdELPKTATGKILRRELR 556
Cdd:cd05974 390 ALEIFRFSRERLAPYKRIRRLEFA-ELPKTISGKIRRVELR 429
|
|
| PRK07638 |
PRK07638 |
acyl-CoA synthetase; Validated |
37-556 |
5.05e-55 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236071 [Multi-domain] Cd Length: 487 Bit Score: 193.07 E-value: 5.05e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 37 ERAPHESALLYFDGRL---DWqaldawsDRIACLL---LDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMN 110
Cdd:PRK07638 12 SLQPNKIAIKENDRVLtykDW-------FESVCKVanwLNEKESKNKTIAILLENRIEFLQLFAGAAMAGWTCVPLDIKW 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 111 RARELKLLLDDSQARVLICDAALEGEVvreviasIEAEGnaapRVFTTRaralqtrddprvfgtqreasgagEGARDLLQ 190
Cdd:PRK07638 85 KQDELKERLAISNADMIVTERYKLNDL-------PDEEG----RVIEID-----------------------EWKRMIEK 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 191 AAQAvqpgrkPPPVVLAASDPAMLVYTSGTSGRPKGAICTHGNF--AFNSqTYRDFcGLREGGPILGVAPLFHITGLVGH 268
Cdd:PRK07638 131 YLPT------YAPIENVQNAPFYMGFTSGSTGKPKAFLRAQQSWlhSFDC-NVHDF-HMKREDSVLIAGTLVHSLFLYGA 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 269 IGAAWIArAPLILTHRFDPAATLDAIEEHRAEFTIGAITVFIALLHhADATREklaTLTKIYSGGAPIAPSVVEAFRAKF 348
Cdd:PRK07638 203 ISTLYVG-QTVHLMRKFIPNQVLDKLETENISVMYTVPTMLESLYK-ENRVIE---NKMKIISSGAKWEAEAKEKIKNIF 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 349 GHV-IHGAYGLTETNSPTHMVPLARTAPvdPHSgalaMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWNNA 427
Cdd:PRK07638 278 PYAkLYEFYGASELSFVTALVDEESERR--PNS----VGRPFHNVQVRICNEAGEEVQKGEIGTVYVKSPQFFMGYIIGG 351
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 428 AATADAFRGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVS 507
Cdd:PRK07638 352 VLARELNADGWMTVRDVGYEDEEGFIYIVGREKNMILFGGINIFPEEIESVLHEHPAVDEIVVIGVPDSYWGEKPVAIIK 431
|
490 500 510 520
....*....|....*....|....*....|....*....|....*....
gi 1595048490 508 LRagavADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:PRK07638 432 GS----ATKQQLKSFCLQRLSSFKIPKEWHFVDEIPYTNSGKIARMEAK 476
|
|
| PLN02574 |
PLN02574 |
4-coumarate--CoA ligase-like |
72-556 |
1.51e-54 |
|
4-coumarate--CoA ligase-like
Pssm-ID: 215312 [Multi-domain] Cd Length: 560 Bit Score: 193.52 E-value: 1.51e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 72 GVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKlllddsqARVLICDAALegevvreVIASIEAEGNA 151
Cdd:PLN02574 88 GVRQGDVVLLLLPNSVYFPVIFLAVLSLGGIVTTMNPSSSLGEIK-------KRVVDCSVGL-------AFTSPENVEKL 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 152 AP-RVFTTRARALQTRDDprvfgtqreasGAGEGARDLLQAAQAVQPGRKPPpvvLAASDPAMLVYTSGTSGRPKGAICT 230
Cdd:PLN02574 154 SPlGVPVIGVPENYDFDS-----------KRIEFPKFYELIKEDFDFVPKPV---IKQDDVAAIMYSSGTTGASKGVVLT 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 231 HGNFAFNSQTYRDFCGLREGGP-----ILGVAPLFHITGLVGHIGAAWIARAPLILTHRFDPAATLDAIEEHRAEFTIGA 305
Cdd:PLN02574 220 HRNLIAMVELFVRFEASQYEYPgsdnvYLAALPMFHIYGLSLFVVGLLSLGSTIVVMRRFDASDMVKVIDRFKVTHFPVV 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 306 ITVFIALLHHADAT-REKLATLTKIYSGGAPIAPSVVEAFRAKFGHV--IHGaYGLTETNSPThmvplARTAPVDPHSGA 382
Cdd:PLN02574 300 PPILMALTKKAKGVcGEVLKSLKQVSCGAAPLSGKFIQDFVQTLPHVdfIQG-YGMTESTAVG-----TRGFNTEKLSKY 373
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 383 LAMGVPVPGAEAAIVD-DDGNMLAAGETGEIVCRGPMVVPGYWNNAAATA-DAFRGGWFHTGDVGFMDEAGWFYLVDRKK 460
Cdd:PLN02574 374 SSVGLLAPNMQAKVVDwSTGCLLPPGNCGELWIQGPGVMKGYLNNPKATQsTIDKDGWLRTGDIAYFDEDGYLYIVDRLK 453
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 461 DMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVADAAELIAFCKARMAAYKYPRIVEFRD 540
Cdd:PLN02574 454 EIIKYKGFQIAPADLEAVLISHPEIIDAAVTAVPDKECGEIPVAFVVRRQGSTLSQEAVINYVAKQVAPYKKVRKVVFVQ 533
|
490
....*....|....*.
gi 1595048490 541 ELPKTATGKILRRELR 556
Cdd:PLN02574 534 SIPKSPAGKILRRELK 549
|
|
| PRK07867 |
PRK07867 |
acyl-CoA synthetase; Validated |
41-556 |
2.08e-54 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236120 [Multi-domain] Cd Length: 529 Bit Score: 192.20 E-value: 2.08e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 41 HESALLYFDGRLDWQALDAWSDRIACLLLDE-GVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLL 119
Cdd:PRK07867 18 DDRGLYFEDSFTSWREHIRGSAARAAALRARlDPTRPPHVGVLLDNTPEFSLLLGAAALSGIVPVGLNPTRRGAALARDI 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 120 DDSQARVLICDAAlegevvreviasieaegnaaprvfttrARALQTRDDP--RVFGTQREASgagegaRDLLqaaqAVQP 197
Cdd:PRK07867 98 AHADCQLVLTESA---------------------------HAELLDGLDPgvRVINVDSPAW------ADEL----AAHR 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 198 GRKPPPVVLAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLVGHIGAAWIARA 277
Cdd:PRK07867 141 DAEPPFRVADPDDLFMLIFTSGTSGDPKAVRCTHRKVASAGVMLAQRFGLGPDDVCYVSMPLFHSNAVMAGWAVALAAGA 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 278 PLILTHRFDPAATLDAIEEHRAEFT--IGAITVFIAllhhadATREKL----ATLTKIYsgGAPIAPSVVEAFRAKFGHV 351
Cdd:PRK07867 221 SIALRRKFSASGFLPDVRRYGATYAnyVGKPLSYVL------ATPERPddadNPLRIVY--GNEGAPGDIARFARRFGCV 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 352 IHGAYGLTETNspthmVPLARTaPVDPhSGALamGVPVPGAE-----------AAIVDDDGNMLAAGETGEIV-CRGPMV 419
Cdd:PRK07867 293 VVDGFGSTEGG-----VAITRT-PDTP-PGAL--GPLPPGVAivdpdtgtecpPAEDADGRLLNADEAIGELVnTAGPGG 363
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 420 VPGYWNNAAATADAFRGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRG 499
Cdd:PRK07867 364 FEGYYNDPEADAERMRGGVYWSGDLAYRDADGYAYFAGRLGDWMRVDGENLGTAPIERILLRYPDATEVAVYAVPDPVVG 443
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*....
gi 1595048490 500 ETVKAVVSLRAGAVADAAELIAFCKAR--MAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:PRK07867 444 DQVMAALVLAPGAKFDPDAFAEFLAAQpdLGPKQWPSYVRVCAELPRTATFKVLKRQLS 502
|
|
| PLN02860 |
PLN02860 |
o-succinylbenzoate-CoA ligase |
68-556 |
2.52e-54 |
|
o-succinylbenzoate-CoA ligase
Pssm-ID: 215464 [Multi-domain] Cd Length: 563 Bit Score: 193.09 E-value: 2.52e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 68 LLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLICDaalegevvreviasiEA 147
Cdd:PLN02860 49 LLRLGLRNGDVVAIAALNSDLYLEWLLAVACAGGIVAPLNYRWSFEEAKSAMLLVRPVMLVTD---------------ET 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 148 EGNAAPRVFTTRARALQTRddprVFGTQREASGAgEGARDLLQAAQAVQPGRKPPPVVLA-ASDPAMLV-YTSGTSGRPK 225
Cdd:PLN02860 114 CSSWYEELQNDRLPSLMWQ----VFLESPSSSVF-IFLNSFLTTEMLKQRALGTTELDYAwAPDDAVLIcFTSGTTGRPK 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 226 GAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLVGHIgAAWIARAPLILTHRFDPAATLDAIEEHRAE--FTI 303
Cdd:PLN02860 189 GVTISHSALIVQSLAKIAIVGYGEDDVYLHTAPLCHIGGLSSAL-AMLMVGACHVLLPKFDAKAALQAIKQHNVTsmITV 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 304 GAITVFIALLHHADATREKLATLTKIYSGGAPIA----PSVVEAF-RAKfghvIHGAYGLTETNS---------PTHMVP 369
Cdd:PLN02860 268 PAMMADLISLTRKSMTWKVFPSVRKILNGGGSLSsrllPDAKKLFpNAK----LFSAYGMTEACSsltfmtlhdPTLESP 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 370 LARTAPVD-------PHSGALAMGVPVPGAEAAIVDDDgnmlaAGETGEIVCRGPMVVPGYWNNAAATA-DAFRGGWFHT 441
Cdd:PLN02860 344 KQTLQTVNqtksssvHQPQGVCVGKPAPHVELKIGLDE-----SSRVGRILTRGPHVMLGYWGQNSETAsVLSNDGWLDT 418
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 442 GDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAG---------- 511
Cdd:PLN02860 419 GDIGWIDKAGNLWLIGRSNDRIKTGGENVYPEEVEAVLSQHPGVASVVVVGVPDSRLTEMVVACVRLRDGwiwsdneken 498
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 1595048490 512 ----AVADAAELIAFCKAR-MAAYKYPR-IVEFRDELPKTATGKILRRELR 556
Cdd:PLN02860 499 akknLTLSSETLRHHCREKnLSRFKIPKlFVQWRKPFPLTTTGKIRRDEVR 549
|
|
| PRK06164 |
PRK06164 |
acyl-CoA synthetase; Validated |
30-556 |
6.41e-54 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 235722 [Multi-domain] Cd Length: 540 Bit Score: 191.11 E-value: 6.41e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 30 DMFAAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPM 109
Cdd:PRK06164 14 SLLDAHARARPDAVALIDEDRPLSRAELRALVDRLAAWLAAQGVRRGDRVAVWLPNCIEWVVLFLACARLGATVIAVNTR 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 110 NRARELKLLLDDSQARVLICDAALEGEVVREVIASIE-AEGNAAPRVFTTRARALQTRDDPRVFGTQREAsgagegardl 188
Cdd:PRK06164 94 YRSHEVAHILGRGRARWLVVWPGFKGIDFAAILAAVPpDALPPLRAIAVVDDAADATPAPAPGARVQLFA---------- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 189 lQAAQAVQPGRKPPPVVlaASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPL---FHITGL 265
Cdd:PRK06164 164 -LPDPAPPAAAGERAAD--PDAGALLFTTSGTTSGPKLVLHRQATLLRHARAIARAYGYDPGAVLLAALPFcgvFGFSTL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 266 VGHIGAAwiarAPLILTHRFDPAATLDAIEEHRAEFTIGAITVFIALLHHADATREkLATLTkiYSGGAPIAPS---VVE 342
Cdd:PRK06164 241 LGALAGG----APLVCEPVFDAARTARALRRHRVTHTFGNDEMLRRILDTAGERAD-FPSAR--LFGFASFAPAlgeLAA 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 343 AFRAKfGHVIHGAYGLTETNSpthmVPLARTAPVDPHSGALAMGVPV-PGAEAAIVD-DDGNMLAAGETGEIVCRGPMVV 420
Cdd:PRK06164 314 LARAR-GVPLTGLYGSSEVQA----LVALQPATDPVSVRIEGGGRPAsPEARVRARDpQDGALLPDGESGEIEIRAPSLM 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 421 PGYWNNAAATADAFRG-GWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVpdPYRG 499
Cdd:PRK06164 389 RGYLDNPDATARALTDdGYFRTGDLGYTRGDGQFVYQTRMGDSLRLGGFLVNPAEIEHALEALPGVAAAQVVGA--TRDG 466
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1595048490 500 ETVK-AVVSLRAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATG---KILRRELR 556
Cdd:PRK06164 467 KTVPvAFVIPTDGASPDEAGLMAACREALAGFKVPARVQVVEAFPVTESAngaKIQKHRLR 527
|
|
| EntF |
COG1020 |
EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites ... |
30-556 |
7.28e-54 |
|
EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440643 [Multi-domain] Cd Length: 1329 Bit Score: 197.39 E-value: 7.28e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 30 DMFAAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPM 109
Cdd:COG1020 480 ELFEAQAARTPDAVAVVFGDQSLTYAELNARANRLAHHLRALGVGPGDLVGVCLERSLEMVVALLAVLKAGAAYVPLDPA 559
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 110 NRARELKLLLDDSQARVLICDAALegevvreviasieaegnaaprvfttrARALQTRDDPRVfgtqreasgagegarDLL 189
Cdd:COG1020 560 YPAERLAYMLEDAGARLVLTQSAL--------------------------AARLPELGVPVL---------------ALD 598
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 190 QAAQAVQPGrKPPPVVLAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPL-FHITglVGH 268
Cdd:COG1020 599 ALALAAEPA-TNPPVPVTPDDLAYVIYTSGSTGRPKGVMVEHRALVNLLAWMQRRYGLGPGDRVLQFASLsFDAS--VWE 675
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 269 IGAAWIARAPLIL---THRFDPAATLDAIEEHRaeftigaITVFI---ALLHH-ADATREKLATLTKIYSGGAPIAPSVV 341
Cdd:COG1020 676 IFGALLSGATLVLappEARRDPAALAELLARHR-------VTVLNltpSLLRAlLDAAPEALPSLRLVLVGGEALPPELV 748
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 342 EAFRAKFGHV-IHGAYGLTETnspTHMVPLARTAPVDPHSGALAMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVV 420
Cdd:COG1020 749 RRWRARLPGArLVNLYGPTET---TVDSTYYEVTPPDADGGSVPIGRPIANTRVYVLDAHLQPVPVGVPGELYIGGAGLA 825
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 421 PGYWNNAAATADAF------RGG--WFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVG 492
Cdd:COG1020 826 RGYLNRPELTAERFvadpfgFPGarLYRTGDLARWLPDGNLEFLGRADDQVKIRGFRIELGEIEAALLQHPGVREAVVVA 905
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1595048490 493 VPDPYRGETVKAVVSLRAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:COG1020 906 REDAPGDKRLVAYVVPEAGAAAAAALLRLALALLLPPYMVPAAVVLLLPLPLTGNGKLDRLALP 969
|
|
| AACS_like |
cd05968 |
Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; This ... |
36-556 |
1.58e-53 |
|
Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; This uncharacterized acyl-CoA synthetase family (EC 6.2.1.16, or acetoacetate#CoA ligase or acetoacetate:CoA ligase (AMP-forming)) is highly homologous to acetoacetyl-CoA synthetase. However, the proteins in this family exist in only bacteria and archaea. AACS is a cytosolic ligase that specifically activates acetoacetate to its coenzyme A ester by a two-step reaction. Acetoacetate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is the first step of the mevalonate pathway of isoprenoid biosynthesis via isopentenyl diphosphate. Isoprenoids are a large class of compounds found in all living organisms.
Pssm-ID: 341272 [Multi-domain] Cd Length: 610 Bit Score: 191.55 E-value: 1.58e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 36 LERAPHESALLYFDGR-----LDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMN 110
Cdd:cd05968 71 LADTRTRPALRWEGEDgtsrtLTYGELLYEVKRLANGLRALGVGKGDRVGIYLPMIPEIVPAFLAVARIGGIVVPIFSGF 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 111 RARELKLLLDDSQARVLIcdaALEGEVVREVIASIEAEGNAAPRVFTTRARALQTRDDPRVFGtqreASGAGEGARDLLQ 190
Cdd:cd05968 151 GKEAAATRLQDAEAKALI---TADGFTRRGREVNLKEEADKACAQCPTVEKVVVVRHLGNDFT----PAKGRDLSYDEEK 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 191 AAQAVQPGRkpppvvLAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFC-GLREGGPILGVAPLFHITG---LV 266
Cdd:cd05968 224 ETAGDGAER------TESEDPLMIIYTSGTTGKPKGTVHVHAGFPLKAAQDMYFQfDLKPGDLLTWFTDLGWMMGpwlIF 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 267 GHIgaawIARAPLILTH---RFDPAATL-DAIEEHRAEFTIGAITVFIALLHHADA--TREKLATLTKIYSGGAPIAPsv 340
Cdd:cd05968 298 GGL----ILGATMVLYDgapDHPKADRLwRMVEDHEITHLGLSPTLIRALKPRGDApvNAHDLSSLRVLGSTGEPWNP-- 371
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 341 vEAFRAKFGHVIHGAYGLTETNSPTHM-------VPLARTAPVdphsgalAMGVPVPGAEAAIVDDDGNMlAAGETGEIV 413
Cdd:cd05968 372 -EPWNWLFETVGKGRNPIINYSGGTEIsggilgnVLIKPIKPS-------SFNGPVPGMKADVLDESGKP-ARPEVGELV 442
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 414 CRGPMV--VPGYWNNAAATADA----FRGGWFHtGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVRE 487
Cdd:cd05968 443 LLAPWPgmTRGFWRDEDRYLETywsrFDNVWVH-GDFAYYDEEGYFYILGRSDDTINVAGKRVGPAEIESVLNAHPAVLE 521
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1595048490 488 AAVVGVPDPYRGETVKAVVSLRAGAVADAA---ELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:cd05968 522 SAAIGVPHPVKGEAIVCFVVLKPGVTPTEAlaeELMERVADELGKPLSPERILFVKDLPKTRNAKVMRRVIR 593
|
|
| PRK13388 |
PRK13388 |
acyl-CoA synthetase; Provisional |
36-556 |
2.27e-53 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 237374 [Multi-domain] Cd Length: 540 Bit Score: 189.85 E-value: 2.27e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 36 LERAPHES-ALLYFDGRLDWQALDAWSDRIACLLLdeGVQRGDR---VALYLQNVPQFVMALLGIWKAGAVMVPVNPMNR 111
Cdd:PRK13388 10 RDRAGDDTiAVRYGDRTWTWREVLAEAAARAAALI--ALADPDRplhVGVLLGNTPEMLFWLAAAALGGYVLVGLNTTRR 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 112 ARELKLLLDDSQARVLICDAALegevvREVIASIEAEGNaapRVFTTraralqtrDDPRVfgtqreasgagegaRDLLQA 191
Cdd:PRK13388 88 GAALAADIRRADCQLLVTDAEH-----RPLLDGLDLPGV---RVLDV--------DTPAY--------------AELVAA 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 192 AQAVQPGRKPppvvlAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLVGHIGA 271
Cdd:PRK13388 138 AGALTPHREV-----DAMDPFMLIFTSGTTGAPKAVRCSHGRLAFAGRALTERFGLTRDDVCYVSMPLFHSNAVMAGWAP 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 272 AWIARAPLILTHRFDPAATLDAIEEHRAEFT--IG-AITVFIALLHHADatrEKLATLTKIYsgGAPIAPSVVEAFRAKF 348
Cdd:PRK13388 213 AVASGAAVALPAKFSASGFLDDVRRYGATYFnyVGkPLAYILATPERPD---DADNPLRVAF--GNEASPRDIAEFSRRF 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 349 GHVIHGAYGLTETnspthmvplARTAPVDPHSGALAMGVPVPGAE-----------AAIVDDDGNMLAAGET-GEIV-CR 415
Cdd:PRK13388 288 GCQVEDGYGSSEG---------AVIVVREPGTPPGSIGRGAPGVAiynpetltecaVARFDAHGALLNADEAiGELVnTA 358
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 416 GPMVVPGYWNNAAATADAFRGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPD 495
Cdd:PRK13388 359 GAGFFEGYYNNPEATAERMRHGMYWSGDLAYRDADGWIYFAGRTADWMRVDGENLSAAPIERILLRHPAINRVAVYAVPD 438
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1595048490 496 PYRGETVKAVVSLRAGAVADAAELIAFCKAR--MAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:PRK13388 439 ERVGDQVMAALVLRDGATFDPDAFAAFLAAQpdLGTKAWPRYVRIAADLPSTATNKVLKRELI 501
|
|
| A_NRPS_Ta1_like |
cd12116 |
The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A ... |
40-555 |
3.21e-53 |
|
The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the myxovirescin (TA) antibiotic biosynthetic gene in Myxococcus xanthus; TA production plays a role in predation. It also includes the salinosporamide A polyketide synthase which is involved in the biosynthesis of salinosporamide A, a marine microbial metabolite whose chlorine atom is crucial for potent proteasome inhibition and anticancer activity.
Pssm-ID: 341281 [Multi-domain] Cd Length: 470 Bit Score: 187.88 E-value: 3.21e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 40 PHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLL 119
Cdd:cd12116 1 PDATAVRDDDRSLSYAELDERANRLAARLRARGVGPGDRVAVYLPRSARLVAAMLAVLKAGAAYVPLDPDYPADRLRYIL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 120 DDSQARVLICDAALEgevvreviasieaegNAAPRVFTTRARALqtrddprvfgtqreasgagegardllqAAQAVQPGR 199
Cdd:cd12116 81 EDAEPALVLTDDALP---------------DRLPAGLPVLLLAL---------------------------AAAAAAPAA 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 200 KPPPVVLAasDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVA-PLFHITGL-------VGhiGA 271
Cdd:cd12116 119 PRTPVSPD--DLAYVIYTSGSTGRPKGVVVSHRNLVNFLHSMRERLGLGPGDRLLAVTtYAFDISLLelllpllAG--AR 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 272 AWIARAplilTHRFDPAATLDAIEEHRaeftigaITVFIA------LLhhADATREKLATLTkIYSGGAPIAPSVVEAFR 345
Cdd:cd12116 195 VVIAPR----ETQRDPEALARLIEAHS-------ITVMQAtpatwrML--LDAGWQGRAGLT-ALCGGEALPPDLAARLL 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 346 AKFGHViHGAYGLTETNSpthmvpLARTAPVDPHSGALAMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWN 425
Cdd:cd12116 261 SRVGSL-WNLYGPTETTI------WSTAARVTAAAGPIPIGRPLANTQVYVLDAALRPVPPGVPGELYIGGDGVAQGYLG 333
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 426 NAAATADAFR--------GGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPY 497
Cdd:cd12116 334 RPALTAERFVpdpfagpgSRLYRTGDLVRRRADGRLEYLGRADGQVKIRGHRIELGEIEAALAAHPGVAQAAVVVREDGG 413
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*...
gi 1595048490 498 RGETVkAVVSLRAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRREL 555
Cdd:cd12116 414 DRRLV-AYVVLKAGAAPDAAALRAHLRATLPAYMVPSAFVRLDALPLTANGKLDRKAL 470
|
|
| PRK13383 |
PRK13383 |
acyl-CoA synthetase; Provisional |
26-555 |
5.88e-53 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 139531 [Multi-domain] Cd Length: 516 Bit Score: 188.28 E-value: 5.88e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 26 TNGLDMFAAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVP 105
Cdd:PRK13383 35 TNPYTLLAVTAARWPGRTAIIDDDGALSYRELQRATESLARRLTRDGVAPGRAVGVMCRNGRGFVTAVFAVGLLGADVVP 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 106 VNPMNRARELKLLLDDSQARVLICDaalegevvREVIASIEAEGNAAPRVfttraralqtrdDPrvfgtqreasgAGEGA 185
Cdd:PRK13383 115 ISTEFRSDALAAALRAHHISTVVAD--------NEFAERIAGADDAVAVI------------DP-----------ATAGA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 186 RDLLQAAQAVQPGRkpppvvlaasdpaMLVYTSGTSGRPKG---------AICThgnfafnSQTYRDFCGLREGGPILGV 256
Cdd:PRK13383 164 EESGGRPAVAAPGR-------------IVLLTSGTTGKPKGvprapqlrsAVGV-------WVTILDRTRLRTGSRISVA 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 257 APLFHITGLvGHIGAAwIARAPLILTHR-FDPAATLDAIEEHRAEFTIGAITVFIALLHHADATREK--LATLTKIYSGG 333
Cdd:PRK13383 224 MPMFHGLGL-GMLMLT-IALGGTVLTHRhFDAEAALAQASLHRADAFTAVPVVLARILELPPRVRARnpLPQLRVVMSSG 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 334 APIAPSVVEAFRAKFGHVIHGAYGLTETNSPthmvplARTAPVDPHSGALAMGVPVPGAEAAIVDDDGNMLAAGETGEIV 413
Cdd:PRK13383 302 DRLDPTLGQRFMDTYGDILYNGYGSTEVGIG------ALATPADLRDAPETVGKPVAGCPVRILDRNNRPVGPRVTGRIF 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 414 CRGPMVVPGYwnnAAATADAFRGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGV 493
Cdd:PRK13383 376 VGGELAGTRY---TDGGGKAVVDGMTSTGDMGYLDNAGRLFIVGREDDMIISGGENVYPRAVENALAAHPAVADNAVIGV 452
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1595048490 494 PDPYRGETVKAVVSLRAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRREL 555
Cdd:PRK13383 453 PDERFGHRLAAFVVLHPGSGVDAAQLRDYLKDRVSRFEQPRDINIVSSIPRNPTGKVLRKEL 514
|
|
| PLN03102 |
PLN03102 |
acyl-activating enzyme; Provisional |
36-556 |
1.35e-52 |
|
acyl-activating enzyme; Provisional
Pssm-ID: 215576 [Multi-domain] Cd Length: 579 Bit Score: 188.69 E-value: 1.35e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 36 LERA----PHESALLYFDGRLDW-QALDAWSdRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMN 110
Cdd:PLN03102 20 LKRAsecyPNRTSIIYGKTRFTWpQTYDRCC-RLAASLISLNITKNDVVSVLAPNTPAMYEMHFAVPMAGAVLNPINTRL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 111 RARELKLLLDDSQARVLICDAALEgEVVREVIASIEAE-GNAAPRVFTtraraLQTRDDP-RVFGTQREASGagegardL 188
Cdd:PLN03102 99 DATSIAAILRHAKPKILFVDRSFE-PLAREVLHLLSSEdSNLNLPVIF-----IHEIDFPkRPSSEELDYEC-------L 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 189 LQAAQavqpgrkPPPVVLAA-------SDPAMLVYTSGTSGRPKGAICTHGNfAFNSqTYRDFCGLREGG-PI-LGVAPL 259
Cdd:PLN03102 166 IQRGE-------PTPSLVARmfriqdeHDPISLNYTSGTTADPKGVVISHRG-AYLS-TLSAIIGWEMGTcPVyLWTLPM 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 260 FHITGLVGHIGAAWIARAPLILTHRFDPAaTLDAIEEHRAEFTIGAITVFIALLHHADATREKLATLTKIYSGGAPIAPS 339
Cdd:PLN03102 237 FHCNGWTFTWGTAARGGTSVCMRHVTAPE-IYKNIEMHNVTHMCCVPTVFNILLKGNSLDLSPRSGPVHVLTGGSPPPAA 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 340 VVEAFRAKFGHVIHGaYGLTETNSPT---------HMVPLARTAPVDPHSGALAMG---VPVPGAEA-AIVDDDGNMLaa 406
Cdd:PLN03102 316 LVKKVQRLGFQVMHA-YGLTEATGPVlfcewqdewNRLPENQQMELKARQGVSILGladVDVKNKETqESVPRDGKTM-- 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 407 getGEIVCRGPMVVPGYWNNAAATADAFRGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVR 486
Cdd:PLN03102 393 ---GEIVIKGSSIMKGYLKNPKATSEAFKHGWLNTGDVGVIHPDGHVEIKDRSKDIIISGGENISSVEVENVLYKYPKVL 469
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 487 EAAVVGVPDPYRGETVKAVVSLRAGA----------VADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:PLN03102 470 ETAVVAMPHPTWGETPCAFVVLEKGEttkedrvdklVTRERDLIEYCRENLPHFMCPRKVVFLQELPKNGNGKILKPKLR 549
|
|
| PRK06018 |
PRK06018 |
putative acyl-CoA synthetase; Provisional |
61-556 |
1.04e-51 |
|
putative acyl-CoA synthetase; Provisional
Pssm-ID: 235673 [Multi-domain] Cd Length: 542 Bit Score: 185.34 E-value: 1.04e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 61 SDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLICDAALegevvre 140
Cdd:PRK06018 49 ALKVSQALDRDGIKLGDRVATIAWNTWRHLEAWYGIMGIGAICHTVNPRLFPEQIAWIINHAEDRVVITDLTF------- 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 141 vIASIEAEGNAAPRV-----FTTRARALQT--------------RDDPRVFGTQREASGAGegardllqaaqavqpgrkp 201
Cdd:PRK06018 122 -VPILEKIADKLPSVeryvvLTDAAHMPQTtlknavayeewiaeADGDFAWKTFDENTAAG------------------- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 202 ppvvlaasdpamLVYTSGTSGRPKGAICTHGNFAFNS--QTYRDFCGLREGGPILGVAPLFHITglvghigaAW-IA-RA 277
Cdd:PRK06018 182 ------------MCYTSGTTGDPKGVLYSHRSNVLHAlmANNGDALGTSAADTMLPVVPLFHAN--------SWgIAfSA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 278 PLILTHRFDPAATLDA------IEEHRAEFTIGAITVFIALLHHADATREKLATLTKIYSGGAPIAPSVVEAFRAKFGHV 351
Cdd:PRK06018 242 PSMGTKLVMPGAKLDGasvyelLDTEKVTFTAGVPTVWLMLLQYMEKEGLKLPHLKMVVCGGSAMPRSMIKAFEDMGVEV 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 352 IHgAYGLTETnSPTHMV----PLARTAPVDPHSGALAM-GVPVPGAEAAIVDDDGNMLAA-GET-GEIVCRGPMVVPGYW 424
Cdd:PRK06018 322 RH-AWGMTEM-SPLGTLaalkPPFSKLPGDARLDVLQKqGYPPFGVEMKITDDAGKELPWdGKTfGRLKVRGPAVAAAYY 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 425 NNAAATADAfrGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKA 504
Cdd:PRK06018 400 RVDGEILDD--DGFFDTGDVATIDAYGYMRITDRSKDVIKSGGEWISSIDLENLAVGHPKVAEAAVIGVYHPKWDERPLL 477
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|..
gi 1595048490 505 VVSLRAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:PRK06018 478 IVQLKPGETATREEILKYMDGKIAKWWMPDDVAFVDAIPHTATGKILKTALR 529
|
|
| PRK07008 |
PRK07008 |
long-chain-fatty-acid--CoA ligase; Validated |
214-556 |
5.67e-51 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 235908 [Multi-domain] Cd Length: 539 Bit Score: 183.37 E-value: 5.67e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 214 LVYTSGTSGRPKGAICTHGNFAFNS--QTYRDFCGLREGGPILGVAPLFHITGLvGHIGAAWIARAPLILT-HRFDPAAT 290
Cdd:PRK07008 181 LCYTSGTTGNPKGALYSHRSTVLHAygAALPDAMGLSARDAVLPVVPMFHVNAW-GLPYSAPLTGAKLVLPgPDLDGKSL 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 291 LDAIEEHRAEFTIGAITVFIALLHHADATREKLATLTKIYSGGAPIAPSVVEAFRAKFG-HVIHgAYGLTEtnspthMVP 369
Cdd:PRK07008 260 YELIEAERVTFSAGVPTVWLGLLNHMREAGLRFSTLRRTVIGGSACPPAMIRTFEDEYGvEVIH-AWGMTE------MSP 332
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 370 LARTA----------PVDPHSGALAMGVPVPGAEAAIVDDDGNMLA-AGET-GEIVCRGPMVVPGYWNNaaaTADAFRGG 437
Cdd:PRK07008 333 LGTLCklkwkhsqlpLDEQRKLLEKQGRVIYGVDMKIVGDDGRELPwDGKAfGDLQVRGPWVIDRYFRG---DASPLVDG 409
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 438 WFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVADAA 517
Cdd:PRK07008 410 WFPTGDVATIDADGFMQITDRSKDVIKSGGEWISSIDIENVAVAHPAVAEAACIACAHPKWDERPLLVVVKRPGAEVTRE 489
|
330 340 350
....*....|....*....|....*....|....*....
gi 1595048490 518 ELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:PRK07008 490 ELLAFYEGKVAKWWIPDDVVFVDAIPHTATGKLQKLKLR 528
|
|
| OSB_MenE-like |
cd17630 |
O-succinylbenzoic acid-CoA ligase; This family contains O-succinylbenzoyl-CoA (OSB-CoA) ... |
210-556 |
7.53e-51 |
|
O-succinylbenzoic acid-CoA ligase; This family contains O-succinylbenzoyl-CoA (OSB-CoA) synthetase (also known as O-succinylbenzoic acid CoA ligase) that belongs to the ANL superfamily and catalyzes the ligation of CoA to o-succinylbenzoate (OSB). It includes MenE in the bacterial menaquinone biosynthesis pathway which is a promising target for the development of novel antibacterial agents. MenE catalyzes CoA ligation via an acyl-adenylate intermediate; tight-binding inhibitors of MenE based on stable acyl-sulfonyladenosine analogs of this intermediate provide a pathway toward the development of optimized MenE inhibitors.
Pssm-ID: 341285 [Multi-domain] Cd Length: 325 Bit Score: 177.52 E-value: 7.53e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 210 DPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLVGHIGAAWIARAPLILTHRFDPAA 289
Cdd:cd17630 1 RLATVILTSGSTGTPKAVVHTAANLLASAAGLHSRLGFGGGDSWLLSLPLYHVGGLAILVRSLLAGAELVLLERNQALAE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 290 TLdaiEEHRAEFTIGAITVFIALLHhADATREKLATLTKIYSGGAPIAPSVVEAFRAKfGHVIHGAYGLTETNSPThmvp 369
Cdd:cd17630 81 DL---APPGVTHVSLVPTQLQRLLD-SGQGPAALKSLRAVLLGGAPIPPELLERAADR-GIPLYTTYGMTETASQV---- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 370 larTAPVDPHSGALAMGVPVPGAEAAIVDDdgnmlaagetGEIVCRGPMVVPGYWNNAAaTADAFRGGWFHTGDVGFMDE 449
Cdd:cd17630 152 ---ATKRPDGFGRGGVGVLLPGRELRIVED----------GEIWVGGASLAMGYLRGQL-VPEFNEDGWFTTKDLGELHA 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 450 AGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGavADAAELIAFCKARMAA 529
Cdd:cd17630 218 DGRLTVLGRADNMIISGGENIQPEEIEAALAAHPAVRDAFVVGVPDEELGQRPVAVIVGRGP--ADPAELRAWLKDKLAR 295
|
330 340
....*....|....*....|....*..
gi 1595048490 530 YKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:cd17630 296 FKLPKRIYPVPELPRTGGGKVDRRALR 322
|
|
| PRK09274 |
PRK09274 |
peptide synthase; Provisional |
38-530 |
1.15e-50 |
|
peptide synthase; Provisional
Pssm-ID: 236443 [Multi-domain] Cd Length: 552 Bit Score: 182.79 E-value: 1.15e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 38 RAPH--ESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNP-MNRaRE 114
Cdd:PRK09274 26 AVPGgrGADGKLAYDELSFAELDARSDAIAHGLNAAGIGRGMRAVLMVTPSLEFFALTFALFKAGAVPVLVDPgMGI-KN 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 115 LKLLLDDSQARVLICDAalEGEVVREVIASieAEGNAAPRVFTTRARALqtrddprvfgtqreasgageGARDLLQAAQa 194
Cdd:PRK09274 105 LKQCLAEAQPDAFIGIP--KAHLARRLFGW--GKPSVRRLVTVGGRLLW--------------------GGTTLATLLR- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 195 VQPGRKPPPVVLAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLVghIGAAWI 274
Cdd:PRK09274 160 DGAAAPFPMADLAPDDMAAILFTSGSTGTPKGVVYTHGMFEAQIEALREDYGIEPGEIDLPTFPLFALFGPA--LGMTSV 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 275 ArAPLILTH--RFDPAATLDAIEEHRAEFTIGAITVFIALLHHADATREKLATLTKIYSGGAPIAPSVVEAFRAKFGHV- 351
Cdd:PRK09274 238 I-PDMDPTRpaTVDPAKLFAAIERYGVTNLFGSPALLERLGRYGEANGIKLPSLRRVISAGAPVPIAVIERFRAMLPPDa 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 352 -IHGAYGLTETnSPTHMV----PLARTAPV-DPHSGALaMGVPVPGAEAAIVD---------DDGNMLAAGETGEIVCRG 416
Cdd:PRK09274 317 eILTPYGATEA-LPISSIesreILFATRAAtDNGAGIC-VGRPVDGVEVRIIAisdapipewDDALRLATGEIGEIVVAG 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 417 PMVVPGYWNNAAATA-----DAFRGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVV 491
Cdd:PRK09274 395 PMVTRSYYNRPEATRlakipDGQGDVWHRMGDLGYLDAQGRLWFCGRKAHRVETAGGTLYTIPCERIFNTHPGVKRSALV 474
|
490 500 510 520
....*....|....*....|....*....|....*....|
gi 1595048490 492 GVPDPyrGETVKA-VVSLRAGAVADAAELIAFCKARMAAY 530
Cdd:PRK09274 475 GVGVP--GAQRPVlCVELEPGVACSKSALYQELRALAAAH 512
|
|
| LC_FACL_like |
cd05914 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); The members of this family are ... |
63-552 |
3.04e-50 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); The members of this family are bacterial long-chain fatty acid CoA synthetase, most of which are as yet uncharacterized. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.
Pssm-ID: 341240 [Multi-domain] Cd Length: 463 Bit Score: 179.56 E-value: 3.04e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 63 RIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLicdaalegevvrevi 142
Cdd:cd05914 19 KFALLLKINGVGTGDRVALMGENRPEWGIAFFAIWTYGAIAVPILAEFTADEVHHILNHSEAKAI--------------- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 143 asieaegnaaprvFTTraralqtrdDPrvfgtqreasgagegardllqaaqavqpgrkpppvvlaaSDPAMLVYTSGTSG 222
Cdd:cd05914 84 -------------FVS---------DE---------------------------------------DDVALINYTSGTTG 102
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 223 RPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLVGHIGAAWIARAPLILTHRFdPAATLDAIEEHRAEFT 302
Cdd:cd05914 103 NSKGVMLTYRNIVSNVDGVKEVVLLGKGDKILSILPLHHIYPLTFTLLLPLLNGAHVVFLDKI-PSAKIIALAFAQVTPT 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 303 IGaITVFIALLHHADATREKLATLTK--------------------------------IYSGGAPIAPSVVEAFR-AKFG 349
Cdd:cd05914 182 LG-VPVPLVIEKIFKMDIIPKLTLKKfkfklakkinnrkirklafkkvheafggnikeFVIGGAKINPDVEEFLRtIGFP 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 350 HVIhgAYGLTETNspthmvPLARTAPvdPHSGALA-MGVPVPGAEAAIVDDDgnmlAAGETGEIVCRGPMVVPGYWNNAA 428
Cdd:cd05914 261 YTI--GYGMTETA------PIISYSP--PNRIRLGsAGKVIDGVEVRIDSPD----PATGEGEIIVRGPNVMKGYYKNPE 326
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 429 ATADAF-RGGWFHTGDVGFMDEAGWFYLVDRKKDMI-NAAGYKVWPREVEDVLYGHPAVREAAVV---------GVPDPY 497
Cdd:cd05914 327 ATAEAFdKDGWFHTGDLGKIDAEGYLYIRGRKKEMIvLSSGKNIYPEEIEAKINNMPFVLESLVVvqekklvalAYIDPD 406
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 498 RgETVKAvvsLRAGAVADAA--ELIAFCKARMAAYKypRIVEFR---DELPKTATGKILR 552
Cdd:cd05914 407 F-LDVKA---LKQRNIIDAIkwEVRDKVNQKVPNYK--KISKVKivkEEFEKTPKGKIKR 460
|
|
| PRK08279 |
PRK08279 |
long-chain-acyl-CoA synthetase; Validated |
10-556 |
5.50e-50 |
|
long-chain-acyl-CoA synthetase; Validated
Pssm-ID: 236217 [Multi-domain] Cd Length: 600 Bit Score: 181.61 E-value: 5.50e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 10 RALYDTGIePNPQQEYTNGlDMFAAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQF 89
Cdd:PRK08279 23 RGLKRTAL-ITPDSKRSLG-DVFEEAAARHPDRPALLFEDQSISYAELNARANRYAHWAAARGVGKGDVVALLMENRPEY 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 90 VMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLICDAALegevvREVIASIEAegnaaprvfttraralQTRDDP 169
Cdd:PRK08279 101 LAAWLGLAKLGAVVALLNTQQRGAVLAHSLNLVDAKHLIVGEEL-----VEAFEEARA----------------DLARPP 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 170 RVFGTQREASGAGEGARDLLQAAQAVqpgRKPPPVV---LAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCG 246
Cdd:PRK08279 160 RLWVAGGDTLDDPEGYEDLAAAAAGA---PTTNPASrsgVTAKDTAFYIYTSGTTGLPKAAVMSHMRWLKAMGGFGGLLR 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 247 LREGGPILGVAPLFHITGLVGHIGAAWIARAPLILTHRFDPAATLDAIEEHRAeftigaiTVFIA-------LLHHADAT 319
Cdd:PRK08279 237 LTPDDVLYCCLPLYHNTGGTVAWSSVLAAGATLALRRKFSASRFWDDVRRYRA-------TAFQYigelcryLLNQPPKP 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 320 REKLATLTKIYsgGAPIAPSVVEAFRAKFG--HVIHGaYGLTETN---------------SPTHMVPLARTAPVDPHSGA 382
Cdd:PRK08279 310 TDRDHRLRLMI--GNGLRPDIWDEFQQRFGipRILEF-YAASEGNvgfinvfnfdgtvgrVPLWLAHPYAIVKYDVDTGE 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 383 lamgvPVPgaeaaivDDDGNML--AAGETGE----IVCRGPMVvpGYwNNAAATA-----DAFRGG--WFHTGDVGFMDE 449
Cdd:PRK08279 387 -----PVR-------DADGRCIkvKPGEVGLligrITDRGPFD--GY-TDPEASEkkilrDVFKKGdaWFNTGDLMRDDG 451
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 450 AGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDP-YRGETVKAVVSLRAGAVADAAELIAFCKARMA 528
Cdd:PRK08279 452 FGHAQFVDRLGDTFRWKGENVATTEVENALSGFPGVEEAVVYGVEVPgTDGRAGMAAIVLADGAEFDLAALAAHLYERLP 531
|
570 580
....*....|....*....|....*...
gi 1595048490 529 AYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:PRK08279 532 AYAVPLFVRLVPELETTGTFKYRKVDLR 559
|
|
| ACS |
cd05966 |
Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); ... |
63-556 |
1.44e-48 |
|
Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Acetyl-CoA synthetase (ACS, EC 6.2.1.1, acetate#CoA ligase or acetate:CoA ligase (AMP-forming)) catalyzes the formation of acetyl-CoA from acetate, CoA, and ATP. Synthesis of acetyl-CoA is carried out in a two-step reaction. In the first step, the enzyme catalyzes the synthesis of acetyl-AMP intermediate from acetate and ATP. In the second step, acetyl-AMP reacts with CoA to produce acetyl-CoA. This enzyme is widely present in all living organisms. The activity of this enzyme is crucial for maintaining the required levels of acetyl-CoA, a key intermediate in many important biosynthetic and catabolic processes. Acetyl-CoA is used in the biosynthesis of glucose, fatty acids, and cholesterol. It can also be used in the production of energy in the citric acid cycle. Eukaryotes typically have two isoforms of acetyl-CoA synthetase, a cytosolic form involved in biosynthetic processes and a mitochondrial form primarily involved in energy generation.
Pssm-ID: 341270 [Multi-domain] Cd Length: 608 Bit Score: 177.75 E-value: 1.44e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 63 RIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLI-CDAALEGEVVREV 141
Cdd:cd05966 96 RFANVLKSLGVKKGDRVAIYMPMIPELVIAMLACARIGAVHSVVFAGFSAESLADRINDAQCKLVItADGGYRGGKVIPL 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 142 IASIEAegnaaprvfttrarALQTRDDPR---VFG-TQREASGAgEGaRDL-LQAAQAVQPgRKPPPVVLAASDPAMLVY 216
Cdd:cd05966 176 KEIVDE--------------ALEKCPSVEkvlVVKrTGGEVPMT-EG-RDLwWHDLMAKQS-PECEPEWMDSEDPLFILY 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 217 TSGTSGRPKGAICTHGNFAFNSQT-------YRD----FCglreggpilgvaplfhiTGLVGHI-GAAWIARAPLIL--- 281
Cdd:cd05966 239 TSGSTGKPKGVVHTTGGYLLYAATtfkyvfdYHPddiyWC-----------------TADIGWItGHSYIVYGPLANgat 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 282 THRF-------DPAATLDAIEEHRAEFTIGAITVFIALLHHADATREK--LATLTKIYSGGAPIAPSVVEAFRAKFGH-- 350
Cdd:cd05966 302 TVMFegtptypDPGRYWDIVEKHKVTIFYTAPTAIRALMKFGDEWVKKhdLSSLRVLGSVGEPINPEAWMWYYEVIGKer 381
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 351 -VIHGAYGLTETNSptHMV-PLARTAPVDPHSGALamgvPVPGAEAAIVDDDGNMLAAGETGEIVCRGPmvvpgyWNNAA 428
Cdd:cd05966 382 cPIVDTWWQTETGG--IMItPLPGATPLKPGSATR----PFFGIEPAILDEEGNEVEGEVEGYLVIKRP------WPGMA 449
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 429 ATA----DAFR-------GGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPY 497
Cdd:cd05966 450 RTIygdhERYEdtyfskfPGYYFTGDGARRDEDGYYWITGRVDDVINVSGHRLGTAEVESALVAHPAVAEAAVVGRPHDI 529
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1595048490 498 RGETVKAVVSLRAGAVAD---AAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:cd05966 530 KGEAIYAFVTLKDGEEPSdelRKELRKHVRKEIGPIATPDKIQFVPGLPKTRSGKIMRRILR 591
|
|
| A_NRPS_Cytc1-like |
cd17643 |
similar to adenylation domain of cytotrienin synthetase CytC1; This family of the adenylation ... |
40-555 |
1.40e-47 |
|
similar to adenylation domain of cytotrienin synthetase CytC1; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes Streptomyces sp. cytotrienin synthetase (CytC1), a relatively promiscuous adenylation enzyme that installs the aminoacyl moieties on the phosphopantetheinyl arm of the holo carrier protein CytC2. Also included are Streptomyces sp Thr1, involved in the biosynthesis of 4-chlorothreonine, Pseudomonas aeruginosa pyoverdine synthetase D (PvdD), involved in the biosynthesis of the siderophore pyoverdine and Pseudomonas syringae syringopeptin synthetase, where syringpeptin is a necrosis-inducing phytotoxin that functions as a virulence determinant in the plant-pathogen interaction. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341298 [Multi-domain] Cd Length: 450 Bit Score: 172.11 E-value: 1.40e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 40 PHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLL 119
Cdd:cd17643 1 PEAVAVVDEDRRLTYGELDARANRLARTLRAEGVGPGDRVALALPRSAELIVALLAILKAGGAYVPIDPAYPVERIAFIL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 120 DDSQARVLICDAalegevvreviasieaegnaaprvfttraralqtrddprvfgtqreasgagegardllqaaqavqpgr 199
Cdd:cd17643 81 ADSGPSLLLTDP-------------------------------------------------------------------- 92
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 200 kpppvvlaaSDPAMLVYTSGTSGRPKGAICTHGNFAfnsqtyrdfCGLREGGPILGVAP-----LFH----------ITG 264
Cdd:cd17643 93 ---------DDLAYVIYTSGSTGRPKGVVVSHANVL---------ALFAATQRWFGFNEddvwtLFHsyafdfsvweIWG 154
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 265 LVGHIG-----AAWIARaplilthrfDPAATLDAIEEHRaeftigaITV-------FIALLHHADATREKLATLTKIYSG 332
Cdd:cd17643 155 ALLHGGrlvvvPYEVAR---------SPEDFARLLRDEG-------VTVlnqtpsaFYQLVEAADRDGRDPLALRYVIFG 218
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 333 GAPIAPSVVEAFRAKFGH----VIHGaYGLTETNSPTHMVPLaRTAPVDPHSGALaMGVPVPGAEAAIVDDDGNMLAAGE 408
Cdd:cd17643 219 GEALEAAMLRPWAGRFGLdrpqLVNM-YGITETTVHVTFRPL-DAADLPAAAASP-IGRPLPGLRVYVLDADGRPVPPGV 295
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 409 TGEIVCRGPMVVPGYWNNAAATADAFRGGWF--------HTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLY 480
Cdd:cd17643 296 VGELYVSGAGVARGYLGRPELTAERFVANPFggpgsrmyRTGDLARRLPDGELEYLGRADEQVKIRGFRIELGEIEAALA 375
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1595048490 481 GHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRREL 555
Cdd:cd17643 376 THPSVRDAAVIVREDEPGDTRLVAYVVADDGAAADIAELRALLKELLPDYMVPARYVPLDALPLTVNGKLDRAAL 450
|
|
| A_NRPS_TubE_like |
cd05906 |
The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) ... |
51-556 |
1.70e-47 |
|
The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino)-acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. This family includes NRPSs that synthesize toxins and antitumor agents; for example, TubE for Tubulysine, CrpA for cryptophycin, TdiA for terrequinone A, KtzG for kutzneride, and Vlm1/Vlm2 for Valinomycin. Nonribosomal peptide synthetases are large multifunctional enzymes which synthesize many therapeutically useful peptides. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and, in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341232 [Multi-domain] Cd Length: 540 Bit Score: 173.62 E-value: 1.70e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 51 RLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNP-----MNRARELKL-----LLD 120
Cdd:cd05906 39 FQSYQDLLEDARRLAAGLRQLGLRPGDSVILQFDDNEDFIPAFWACVLAGFVPAPLTVpptydEPNARLRKLrhiwqLLG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 121 DsqarvlicdaalegevvreviasieaegnaaPRVFTTRARALQTRDDPRVFGTQREASGAGEGARDllqaaqavqPGRK 200
Cdd:cd05906 119 S-------------------------------PVVLTDAELVAEFAGLETLSGLPGIRVLSIEELLD---------TAAD 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 201 PPPVVLAASDPAMLVYTSGTSGRPKGAICTHGN----FAFNSQTyrdfCGLREGGPILGVAPLFHITGLVG-HI-----G 270
Cdd:cd05906 159 HDLPQSRPDDLALLMLTSGSTGFPKAVPLTHRNilarSAGKIQH----NGLTPQDVFLNWVPLDHVGGLVElHLravylG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 271 AAWI-ARAPLILThrfDPAATLDAIEEHRAEFTIgAITVFIALLhhADATREK------LATLTKIYSGGAPIAPSVVEA 343
Cdd:cd05906 235 CQQVhVPTEEILA---DPLRWLDLIDRYRVTITW-APNFAFALL--NDLLEEIedgtwdLSSLRYLVNAGEAVVAKTIRR 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 344 FR---AKFG---HVIHGAYGLTETNSpthMVPLARTAPVDPHSGAL---AMGVPVPGAEAAIVDDDGNMLAAGETGEIVC 414
Cdd:cd05906 309 LLrllEPYGlppDAIRPAFGMTETCS---GVIYSRSFPTYDHSQALefvSLGRPIPGVSMRIVDDEGQLLPEGEVGRLQV 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 415 RGPMVVPGYWNNAAATADAFR-GGWFHTGDVGFMDEaGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVRE--AAVV 491
Cdd:cd05906 386 RGPVVTKGYYNNPEANAEAFTeDGWFRTGDLGFLDN-GNLTITGRTKDTIIVNGVNYYSHEIEAAVEEVPGVEPsfTAAF 464
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 492 GVPDPYRGETVKAVVSL-RAGAVADAAELIAFCK---ARMAAYKYPRIVEF-RDELPKTATGKILRRELR 556
Cdd:cd05906 465 AVRDPGAETEELAIFFVpEYDLQDALSETLRAIRsvvSREVGVSPAYLIPLpKEEIPKTSLGKIQRSKLK 534
|
|
| Ac_CoA_lig_AcsA |
TIGR02188 |
acetate--CoA ligase; This model describes acetate-CoA ligase (EC 6.2.1.1), also called ... |
63-556 |
4.70e-47 |
|
acetate--CoA ligase; This model describes acetate-CoA ligase (EC 6.2.1.1), also called acetyl-CoA synthetase and acetyl-activating enzyme. It catalyzes the reaction ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA and belongs to the family of AMP-binding enzymes described by pfam00501.
Pssm-ID: 274022 [Multi-domain] Cd Length: 626 Bit Score: 173.97 E-value: 4.70e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 63 RIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLIC-DAALEGEVV--- 138
Cdd:TIGR02188 100 RFANVLKSLGVKKGDRVAIYMPMIPEAAIAMLACARIGAIHSVVFGGFSAEALADRINDAGAKLVITaDEGLRGGKVipl 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 139 -REVIASIEAEGNAAPRVFTTRAralqtrddprvfgTQREASGAGEGaRDL-LQAAQAVQPgRKPPPVVLAASDPAMLVY 216
Cdd:TIGR02188 180 kAIVDEALEKCPVSVEHVLVVRR-------------TGNPVVPWVEG-RDVwWHDLMAKAS-AYCEPEPMDSEDPLFILY 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 217 TSGTSGRPKGAICTHGNFAFNSQ-TYRDFCGLREGGpilgvapLFHITGLVGHI-GAAWIARAPLIL---THRF------ 285
Cdd:TIGR02188 245 TSGSTGKPKGVLHTTGGYLLYAAmTMKYVFDIKDGD-------IFWCTADVGWItGHSYIVYGPLANgatTVMFegvpty 317
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 286 -DPAATLDAIEEHRAEFTIGAITVFIALLHHADA--TREKLATLTKIYSGGAPIAPSVVEAFRAKFGH---VIHGAYGLT 359
Cdd:TIGR02188 318 pDPGRFWEIIEKHKVTIFYTAPTAIRALMRLGDEwvKKHDLSSLRLLGSVGEPINPEAWMWYYKVVGKercPIVDTWWQT 397
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 360 ETNSptHMV-PLARTAPVDPHSGALamgvPVPGAEAAIVDDDGNML-AAGETGEIVCRGPMvvPG--------------- 422
Cdd:TIGR02188 398 ETGG--IMItPLPGATPTKPGSATL----PFFGIEPAVVDEEGNPVeGPGEGGYLVIKQPW--PGmlrtiygdherfvdt 469
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 423 YWNnaaatadAFRGGWFhTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETV 502
Cdd:TIGR02188 470 YFS-------PFPGYYF-TGDGARRDKDGYIWITGRVDDVINVSGHRLGTAEIESALVSHPAVAEAAVVGIPDDIKGQAI 541
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*..
gi 1595048490 503 KAVVSLRAGAVAD---AAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:TIGR02188 542 YAFVTLKDGYEPDdelRKELRKHVRKEIGPIAKPDKIRFVPGLPKTRSGKIMRRLLR 598
|
|
| AFD_YhfT-like |
cd17633 |
fatty acid-CoA ligase VraA; This family of acyl-CoA ligases includes Bacillus subtilis YhfT, ... |
210-552 |
3.69e-46 |
|
fatty acid-CoA ligase VraA; This family of acyl-CoA ligases includes Bacillus subtilis YhfT, as well as long-chain fatty acid-CoA ligase VraA, all of which are as yet to be characterized. These proteins belong to the adenylate-forming enzymes which catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain
Pssm-ID: 341288 [Multi-domain] Cd Length: 320 Bit Score: 164.50 E-value: 3.69e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 210 DPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLVGHIGAAWIARApLILTHRFDPAA 289
Cdd:cd17633 1 NPFYIGFTSGTTGLPKAYYRSERSWIESFVCNEDLFNISGEDAILAPGPLSHSLFLYGAISALYLGGT-FIGQRKFNPKS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 290 TLDAIEEHRAEFTIGAITVFIALLHHadatREKLATLTKIYSGGAPIAPSVVEAFRAKFGH-VIHGAYGLTETNSPTHMV 368
Cdd:cd17633 80 WIRKINQYNATVIYLVPTMLQALART----LEPESKIKSIFSSGQKLFESTKKKLKNIFPKaNLIEFYGTSELSFITYNF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 369 PlARTAPvdPHSgalaMGVPVPGAEAAIVDDDGnmlaaGETGEIVCRGPMVVPGYWNNAAATADafrgGWFHTGDVGFMD 448
Cdd:cd17633 156 N-QESRP--PNS----VGRPFPNVEIEIRNADG-----GEIGKIFVKSEMVFSGYVRGGFSNPD----GWMSVGDIGYVD 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 449 EAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSlraGAVADAAELIAFCKARMA 528
Cdd:cd17633 220 EEGYLYLVGRESDMIIIGGINIFPTEIESVLKAIPGIEEAIVVGIPDARFGEIAVALYS---GDKLTYKQLKRFLKQKLS 296
|
330 340
....*....|....*....|....
gi 1595048490 529 AYKYPRIVEFRDELPKTATGKILR 552
Cdd:cd17633 297 RYEIPKKIIFVDSLPYTSSGKIAR 320
|
|
| FACL_like_4 |
cd05944 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ... |
209-556 |
3.82e-46 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341266 [Multi-domain] Cd Length: 359 Bit Score: 165.73 E-value: 3.82e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 209 SDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLVGHIGAAWIARAPLILT----HR 284
Cdd:cd05944 2 DDVAAYFHTGGTTGTPKLAQHTHSNEVYNAWMLALNSLFDPDDVLLCGLPLFHVNGSVVTLLTPLASGAHVVLAgpagYR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 285 fDPAATLD---AIEEHRAEFTIGAITVFIALLH---HADATREKLAtltkiYSGGAPIAPSVVEAFRAKFGHVIHGAYGL 358
Cdd:cd05944 82 -NPGLFDNfwkLVERYRITSLSTVPTVYAALLQvpvNADISSLRFA-----MSGAAPLPVELRARFEDATGLPVVEGYGL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 359 TETNSPTHMVPlaRTAPVDPHSgalaMGVPVPGAEAAIV--DDDGNML---AAGETGEIVCRGPMVVPGYWNNAAATADA 433
Cdd:cd05944 156 TEATCLVAVNP--PDGPKRPGS----VGLRLPYARVRIKvlDGVGRLLrdcAPDEVGEICVAGPGVFGGYLYTEGNKNAF 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 434 FRGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAV 513
Cdd:cd05944 230 VADGWLNTGDLGRLDADGYLFITGRAKDLIIRGGHNIDPALIEEALLRHPAVAFAGAVGQPDAHAGELPVAYVQLKPGAV 309
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1595048490 514 ADAAELIAFCKARMAAY-KYPRIVEFRDELPKTATGKILRRELR 556
Cdd:cd05944 310 VEEEELLAWARDHVPERaAVPKHIEVLEELPVTAVGKVFKPALR 353
|
|
| FACL_like_5 |
cd05924 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ... |
210-549 |
4.90e-46 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341248 [Multi-domain] Cd Length: 364 Bit Score: 165.63 E-value: 4.90e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 210 DPAMLVYTSGTSGRPKGAICTHG----------NFAFNSQTYRDFCGLR----EGGPILGVAPLFHITGLVGHIGAAWIA 275
Cdd:cd05924 4 DDLYILYTGGTTGMPKGVMWRQEdifrmlmggaDFGTGEFTPSEDAHKAaaaaAGTVMFPAPPLMHGTGSWTAFGGLLGG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 276 RAPLILTHRFDPAATLDAIEEHRAEFTIGAITVFIALLhhADATREK----LATLTKIYSGGAPIAPSVVEAFRAKFGH- 350
Cdd:cd05924 84 QTVVLPDDRFDPEEVWRTIEKHKVTSMTIVGDAMARPL--IDALRDAgpydLSSLFAISSGGALLSPEVKQGLLELVPNi 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 351 VIHGAYGLTET-NSPTHMVplartAPVDPHSGALAMgvpvPGAEAAIVDDDGNML--AAGETGEIVCRGpmVVP-GYWNN 426
Cdd:cd05924 162 TLVDAFGSSETgFTGSGHS-----AGSGPETGPFTR----ANPDTVVLDDDGRVVppGSGGVGWIARRG--HIPlGYYGD 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 427 AAATADAFR--GG--WFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETV 502
Cdd:cd05924 231 EAKTAETFPevDGvrYAVPGDRATVEADGTVTLLGRGSVCINTGGEKVFPEEVEEALKSHPAVYDVLVVGRPDERWGQEV 310
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1595048490 503 KAVVSLRAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGK 549
Cdd:cd05924 311 VAVVQLREGAGVDLEELREHCRTRIARYKLPKQVVFVDEIERSPAGK 357
|
|
| PRK05620 |
PRK05620 |
long-chain fatty-acid--CoA ligase; |
64-556 |
7.87e-45 |
|
long-chain fatty-acid--CoA ligase;
Pssm-ID: 180167 [Multi-domain] Cd Length: 576 Bit Score: 166.88 E-value: 7.87e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 64 IACLLLDE-GVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLICDAALEGEVVrEVI 142
Cdd:PRK05620 51 LAHALHDElGITGDQRVGSMMYNCAEHLEVLFAVACMGAVFNPLNKQLMNDQIVHIINHAEDEVIVADPRLAEQLG-EIL 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 143 ASieaegnaAPRVfttRARALQTRDDprvfgTQREASGAGEGARdlLQAAQAVQPGRK---PPPVvLAASDPAMLVYTSG 219
Cdd:PRK05620 130 KE-------CPCV---RAVVFIGPSD-----ADSAAAHMPEGIK--VYSYEALLDGRStvyDWPE-LDETTAAAICYSTG 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 220 TSGRPKGAICTHGNFAFNSQTYR--DFCGLREGGPILGVAPLFHITGLvGHIGAAWIARAPLILT-HRFDPAATLDAIEE 296
Cdd:PRK05620 192 TTGAPKGVVYSHRSLYLQSLSLRttDSLAVTHGESFLCCVPIYHVLSW-GVPLAAFMSGTPLVFPgPDLSAPTLAKIIAT 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 297 HRAEFTIGAITVFIALLHHADATREKLATLTKIYSGGAPIAPSVVEAFRAKFG-HVIHgAYGLTETnSPTHMVplARtap 375
Cdd:PRK05620 271 AMPRVAHGVPTLWIQLMVHYLKNPPERMSLQEIYVGGSAVPPILIKAWEERYGvDVVH-VWGMTET-SPVGTV--AR--- 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 376 vdPHSGA---------LAMGVPVPGAEAAIVDDdGNMLAAGE--TGEIVCRGPMVVPGYWNNAAAT----ADAFRG---- 436
Cdd:PRK05620 344 --PPSGVsgearwayrVSQGRFPASLEYRIVND-GQVMESTDrnEGEIQVRGNWVTASYYHSPTEEgggaASTFRGedve 420
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 437 ---------GWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVS 507
Cdd:PRK05620 421 dandrftadGWLRTGDVGSVTRDGFLTIHDRARDVIRSGGEWIYSAQLENYIMAAPEVVECAVIGYPDDKWGERPLAVTV 500
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|..
gi 1595048490 508 LRAG---AVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:PRK05620 501 LAPGiepTRETAERLRDQLRDRLPNWMLPEYWTFVDEIDKTSVGKFDKKDLR 552
|
|
| FACL_like_1 |
cd05910 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ... |
51-530 |
1.45e-43 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341236 [Multi-domain] Cd Length: 457 Bit Score: 161.09 E-value: 1.45e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 51 RLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDsqarvlicd 130
Cdd:cd05910 2 RLSFRELDERSDRIAQGLTAYGIRRGMRAVLMVPPGPDFFALTFALFKAGAVPVLIDPGMGRKNLKQCLQE--------- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 131 aalegevvreviasieaegnAAPRVFTTRARALqtrddprvfgtqreasgagegardllqaaqavqpgrkpppvvlaasD 210
Cdd:cd05910 73 --------------------AEPDAFIGIPKAD----------------------------------------------E 86
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 211 PAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLVghIGAAWIA-----RAPLilthRF 285
Cdd:cd05910 87 PAAILFTSGSTGTPKGVVYRHGTFAAQIDALRQLYGIRPGEVDLATFPLFALFGPA--LGLTSVIpdmdpTRPA----RA 160
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 286 DPAATLDAIEEHRAEFTIGAITVFIALLHHADATREKLATLTKIYSGGAPIAPSVVEAFRAKF--GHVIHGAYGLTE--- 360
Cdd:cd05910 161 DPQKLVGAIRQYGVSIVFGSPALLERVARYCAQHGITLPSLRRVLSAGAPVPIALAARLRKMLsdEAEILTPYGATEalp 240
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 361 -TNSPTHMVPLARTAPVDPHSGaLAMGVPVPGAEAAIVD---------DDGNMLAAGETGEIVCRGPMVVPGYWNNAAAT 430
Cdd:cd05910 241 vSSIGSRELLATTTAATSGGAG-TCVGRPIPGVRVRIIEiddepiaewDDTLELPRGEIGEITVTGPTVTPTYVNRPVAT 319
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 431 A-----DAFRGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVkAV 505
Cdd:cd05910 320 AlakidDNSEGFWHRMGDLGYLDDEGRLWFCGRKAHRVITTGGTLYTEPVERVFNTHPGVRRSALVGVGKPGCQLPV-LC 398
|
490 500
....*....|....*....|....*
gi 1595048490 506 VSLRAGAVADAAELIAFCKARMAAY 530
Cdd:cd05910 399 VEPLPGTITPRARLEQELRALAKDY 423
|
|
| A_NRPS_TlmIV_like |
cd12114 |
The adenylation domain of nonribosomal peptide synthetases (NRPS), including ... |
40-555 |
3.22e-42 |
|
The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the TLM biosynthetic gene cluster from Streptoalloteichus that consists of nine NRPS genes; the N-terminal module of TlmVI (NRPS-5) and the starter module of BlmVI (NRPS-5) are comprised of the acyl CoA ligase (AL) and acyl carrier protein (ACP)-like domains, which are thought to be involved in the biosynthesis of the beta-aminoalaninamide moiety.
Pssm-ID: 341279 [Multi-domain] Cd Length: 477 Bit Score: 157.82 E-value: 3.22e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 40 PHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLL 119
Cdd:cd12114 1 PDATAVICGDGTLTYGELAERARRVAGALKAAGVRPGDLVAVTLPKGPEQVVAVLGILAAGAAYVPVDIDQPAARREAIL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 120 DDSQARVLICDAALEGEVVreviasieaegnaaprvfttraralqtrddprvfgtqreasgagEGARDLLQAAQAVQPGR 199
Cdd:cd12114 81 ADAGARLVLTDGPDAQLDV--------------------------------------------AVFDVLILDLDALAAPA 116
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 200 KPPPVVLAASDPAMLVYTSGTSGRPKGAICTHGNfAFNS--QTYRDFcGLREGGPILGVAPL------FHITGLVGhIGA 271
Cdd:cd12114 117 PPPPVDVAPDDLAYVIFTSGSTGTPKGVMISHRA-ALNTilDINRRF-AVGPDDRVLALSSLsfdlsvYDIFGALS-AGA 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 272 AWIARAPLiltHRFDPAATLDAIEEHRaeftigaITV-------FIALLHHADATREKLATLTKIYSGGAPIAPSVVEAF 344
Cdd:cd12114 194 TLVLPDEA---RRRDPAHWAELIERHG-------VTLwnsvpalLEMLLDVLEAAQALLPSLRLVLLSGDWIPLDLPARL 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 345 RAKFGHV-IHGAYGLTETN--SPTHMVplartAPVDPHSGALAMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVP 421
Cdd:cd12114 264 RALAPDArLISLGGATEASiwSIYHPI-----DEVPPDWRSIPYGRPLANQRYRVLDPRGRDCPDWVPGELWIGGRGVAL 338
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 422 GYWNNAAATADAF-----RGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDP 496
Cdd:cd12114 339 GYLGDPELTAARFvthpdGERLYRTGDLGRYRPDGTLEFLGRRDGQVKVRGYRIELGEIEAALQAHPGVARAVVVVLGDP 418
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*....
gi 1595048490 497 YRGETVKAVVSLRAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRREL 555
Cdd:cd12114 419 GGKRLAAFVVPDNDGTPIAPDALRAFLAQTLPAYMIPSRVIALEALPLTANGKVDRAAL 477
|
|
| A_NRPS_CmdD_like |
cd17652 |
similar to adenylation domain of chondramide synthase cmdD; This family of the adenylation (A) ... |
40-555 |
3.96e-42 |
|
similar to adenylation domain of chondramide synthase cmdD; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes phosphinothricin tripeptide (PTT, phosphinothricylalanylalanine) synthetase, where PTT is a natural-product antibiotic and potent herbicide that is produced by Streptomyces hygroscopicus. This adenylation domain has been confirmed to directly activate beta-tyrosine, and fluorinated chondramides are produced through precursor-directed biosynthesis. Also included in this family is chondramide synthase D (also known as ATP-dependent phenylalanine adenylase or phenylalanine activase or tyrosine activase). Chondramides A-D are depsipeptide antitumor and antifungal antibiotics produced by C. crocatus, are a class of mixed peptide/polyketide depsipeptides comprised of three amino acids (alanine, N-methyltryptophan, plus the unusual amino acid beta-tyrosine or alpha-methoxy-beta-tyrosine) and a polyketide chain ([E]-7-hydroxy-2,4,6-trimethyloct-4-enoic acid).
Pssm-ID: 341307 [Multi-domain] Cd Length: 436 Bit Score: 156.64 E-value: 3.96e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 40 PHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLL 119
Cdd:cd17652 1 PDAPAVVFGDETLTYAELNARANRLARLLAARGVGPERLVALALPRSAELVVAILAVLKAGAAYLPLDPAYPAERIAYML 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 120 DDSQARVLIcdaalegevvreviasieaegnaaprvfttraralqtrddprvfgTQreasgagegardllqaaqavqpgr 199
Cdd:cd17652 81 ADARPALLL---------------------------------------------TT------------------------ 91
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 200 kpppvvlaASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVA-PLFHITglVGHIGAAWIARAP 278
Cdd:cd17652 92 --------PDNLAYVIYTSGSTGRPKGVVVTHRGLANLAAAQIAAFDVGPGSRVLQFAsPSFDAS--VWELLMALLAGAT 161
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 279 LILThrfdPAATLDAIEEHRAEFTIGAITVFI----ALLHHADATREKLATLTkiySGGAPIAPSVVEafRAKFGHVIHG 354
Cdd:cd17652 162 LVLA----PAEELLPGEPLADLLREHRITHVTlppaALAALPPDDLPDLRTLV---VAGEACPAELVD--RWAPGRRMIN 232
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 355 AYGLTETNSpthmvpLARTAPVDPHSGALAMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWNNAAATADAF 434
Cdd:cd17652 233 AYGPTETTV------CATMAGPLPGGGVPPIGRPVPGTRVYVLDARLRPVPPGVPGELYIAGAGLARGYLNRPGLTAERF 306
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 435 RGGWF--------HTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVV 506
Cdd:cd17652 307 VADPFgapgsrmyRTGDLARWRADGQLEFLGRADDQVKIRGFRIELGEVEAALTEHPGVAEAVVVVRDDRPGDKRLVAYV 386
|
490 500 510 520
....*....|....*....|....*....|....*....|....*....
gi 1595048490 507 SLRAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRREL 555
Cdd:cd17652 387 VPAPGAAPTAAELRAHLAERLPGYMVPAAFVVLDALPLTPNGKLDRRAL 435
|
|
| AAS_C |
cd05909 |
C-terminal domain of the acyl-acyl carrier protein synthetase (also called ... |
208-556 |
9.13e-42 |
|
C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Acyl-acyl carrier protein synthase (Aas) is a membrane protein responsible for a minor pathway of incorporating exogenous fatty acids into membrane phospholipids. Its in vitro activity is characterized by the ligation of free fatty acids between 8 and 18 carbons in length to the acyl carrier protein sulfydryl group (ACP-SH) in the presence of ATP and Mg2+. However, its in vivo function is as a 2-acylglycerophosphoethanolamine (2-acyl-GPE) acyltransferase. The reaction occurs in two steps: the acyl chain is first esterified to acyl carrier protein (ACP) via a thioester bond, followed by a second step where the acyl chain is transferred to a 2-acyllysophospholipid, thus completing the transacylation reaction. This model represents the C-terminal domain of the enzyme, which belongs to the class I adenylate-forming enzyme family, including acyl-CoA synthetases.
Pssm-ID: 341235 [Multi-domain] Cd Length: 490 Bit Score: 156.72 E-value: 9.13e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 208 ASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLVGHIGAAWIARAPLIL-THRFD 286
Cdd:cd05909 146 PDDPAVILFTSGSEGLPKGVVLSHKNLLANVEQITAIFDPNPEDVVFGALPFFHSFGLTGCLWLPLLSGIKVVFhPNPLD 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 287 PAATLDAIEEHRAEFTIGAITVFIALLHHAdaTREKLATLTKIYSGGAPIAPSVVEAFRAKFGHVIHGAYGLTETnSPth 366
Cdd:cd05909 226 YKKIPELIYDKKATILLGTPTFLRGYARAA--HPEDFSSLRLVVAGAEKLKDTLRQEFQEKFGIRILEGYGTTEC-SP-- 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 367 mVPLARTAPVDPHSGALamGVPVPGAEAAIVD-DDGNMLAAGETGEIVCRGPMVVPGYWNNAAATADAFRGGWFHTGDVG 445
Cdd:cd05909 301 -VISVNTPQSPNKEGTV--GRPLPGMEVKIVSvETHEEVPIGEGGLLLVRGPNVMLGYLNEPELTSFAFGDGWYDTGDIG 377
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 446 FMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGH-PAVREAAVVGVPDPYRGEtvkAVVSLRAGAVADAAELIAFCK 524
Cdd:cd05909 378 KIDGEGFLTITGRLSRFAKIAGEMVSLEAIEDILSEIlPEDNEVAVVSVPDGRKGE---KIVLLTTTTDTDPSSLNDILK 454
|
330 340 350
....*....|....*....|....*....|...
gi 1595048490 525 ARMAAYKY-PRIVEFRDELPKTATGKILRRELR 556
Cdd:cd05909 455 NAGISNLAkPSYIHQVEEIPLLGTGKPDYVTLK 487
|
|
| FATP_FACS |
cd05940 |
Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its ... |
49-556 |
1.66e-41 |
|
Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Fatty acid transport protein (FATP) transports long-chain or very-long-chain fatty acids across the plasma membrane. FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. At least five copies of FATPs are identified in mammalian cells. This family also includes prokaryotic FATPs. FATPs are the key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis.
Pssm-ID: 341263 [Multi-domain] Cd Length: 449 Bit Score: 155.20 E-value: 1.66e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 49 DGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLI 128
Cdd:cd05940 1 DEALTYAELDAMANRYARWLKSLGLKPGDVVALFMENRPEYVLLWLGLVKIGAVAALINYNLRGESLAHCLNVSSAKHLV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 129 cdaalegevvreviasieaegnaaprvfttraralqtrddprvfgtqreasgagegardllqaaqavqpgrkpppvvlaa 208
Cdd:cd05940 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 209 SDPAMLVYTSGTSGRPKGAICTHGNfAFNSQTYRDFCGLREGGPIL-GVAPLFHITGLVGHIGAAWIARAPLILTHRFDP 287
Cdd:cd05940 81 VDAALYIYTSGTTGLPKAAIISHRR-AWRGGAFFAGSGGALPSDVLyTCLPLYHSTALIVGWSACLASGATLVIRKKFSA 159
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 288 AATLDAIEEHRAeftigAITVFIA-----LLHHADATREKLATLTKIYSGGapIAPSVVEAFRAKFGhVIHGA--YGLTE 360
Cdd:cd05940 160 SNFWDDIRKYQA-----TIFQYIGelcryLLNQPPKPTERKHKVRMIFGNG--LRPDIWEEFKERFG-VPRIAefYAATE 231
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 361 TNSPTHMVP-----LARTAPVDPHSGALAMGVPVPGAEAAIVDDDGNMLAA--GETGEIVCRGPMVVP--GYWNNAAATA 431
Cdd:cd05940 232 GNSGFINFFgkpgaIGRNPSLLRKVAPLALVKYDLESGEPIRDAEGRCIKVprGEPGLLISRINPLEPfdGYTDPAATEK 311
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 432 ----DAFRGG--WFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDP-YRGETVKA 504
Cdd:cd05940 312 kilrDVFKKGdaWFNTGDLMRLDGEGFWYFVDRLGDTFRWKGENVSTTEVAAVLGAFPGVEEANVYGVQVPgTDGRAGMA 391
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|..
gi 1595048490 505 VVSLRAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:cd05940 392 AIVLQPNEEFDLSALAAHLEKNLPGYARPLFLRLQPEMEITGTFKQQKVDLR 443
|
|
| A_NRPS_Sfm_like |
cd12115 |
The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene ... |
30-555 |
3.54e-41 |
|
The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the saframycin A gene cluster from Streptomyces lavendulae which implicates the NRPS system for assembling the unusual tetrapeptidyl skeleton in an iterative manner. It also includes saframycin Mx1 produced by Myxococcus xanthus NRPS.
Pssm-ID: 341280 [Multi-domain] Cd Length: 447 Bit Score: 154.40 E-value: 3.54e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 30 DMFAAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPM 109
Cdd:cd12115 3 DLVEAQAARTPDAIALVCGDESLTYAELNRRANRLAARLRAAGVGPESRVGVCLERTPDLVVALLAVLKAGAAYVPLDPA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 110 NRARELKLLLDDSQARVLICDAAlegevvreviasieaegnaaprvfttraralqtrddprvfgtqreasgagegardll 189
Cdd:cd12115 83 YPPERLRFILEDAQARLVLTDPD--------------------------------------------------------- 105
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 190 qaaqavqpgrkpppvvlaasDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAP------LFHIT 263
Cdd:cd12115 106 --------------------DLAYVIYTSGSTGRPKGVAIEHRNAAAFLQWAAAAFSAEELAGVLASTSicfdlsVFELF 165
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 264 GLVGHIGAAWIARAPLILthrFDPAAtldaieehRAEFT-IGAITVFIALLHHADATREKLATLTkiySGGAPIAPSVVE 342
Cdd:cd12115 166 GPLATGGKVVLADNVLAL---PDLPA--------AAEVTlINTVPSAAAELLRHDALPASVRVVN---LAGEPLPRDLVQ 231
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 343 AFRAKF-GHVIHGAYGLTE--TNSPTHMVPLArtapvdpHSGALAMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMV 419
Cdd:cd12115 232 RLYARLqVERVVNLYGPSEdtTYSTVAPVPPG-------ASGEVSIGRPLANTQAYVLDRALQPVPLGVPGELYIGGAGV 304
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 420 VPGYWNNAAATADAFRGGWFH-------TGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVG 492
Cdd:cd12115 305 ARGYLGRPGLTAERFLPDPFGpgarlyrTGDLVRWRPDGLLEFLGRADNQVKVRGFRIELGEIEAALRSIPGVREAVVVA 384
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1595048490 493 VPDPYRGETVKAVVSLRAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRREL 555
Cdd:cd12115 385 IGDAAGERRLVAYIVAEPGAAGLVEDLRRHLGTRLPAYMVPSRFVRLDALPLTPNGKIDRSAL 447
|
|
| A_NRPS_PvdJ-like |
cd17649 |
non-ribosomal peptide synthetase; This family of the adenylation (A) domain of nonribosomal ... |
40-556 |
6.83e-41 |
|
non-ribosomal peptide synthetase; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes pyoverdine biosynthesis protein PvdJ involved in the synthesis of pyoverdine, which consists of a chromophore group attached to a variable peptide chain and comprises around 6-12 amino acids that are specific for each Pseudomonas species, and for which the peptide might be first synthesized before the chromophore assembly. Also included is ornibactin biosynthesis protein OrbI; ornibactin is a tetrapeptide siderophore with an l-ornithine-d-hydroxyaspartate-l-serine-l-ornithine backbone. The adenylation domain at the N-terminal of OrbI possibly initiates the ornibactin with the binding of N5-hydroxyornithine. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341304 [Multi-domain] Cd Length: 450 Bit Score: 153.68 E-value: 6.83e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 40 PHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLL 119
Cdd:cd17649 1 PDAVALVFGDQSLSYAELDARANRLAHRLRALGVGPEVRVGIALERSLEMVVALLAILKAGGAYVPLDPEYPAERLRYML 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 120 DDSQARVLICdaalegevvreviasieaegnAAPRvfttraralqtrddprvfgtqreasgagegardllqaaqavqpgr 199
Cdd:cd17649 81 EDSGAGLLLT---------------------HHPR--------------------------------------------- 94
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 200 kpppvvlaasDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPlFHITGLVGHIGAAWIARAPL 279
Cdd:cd17649 95 ----------QLAYVIYTSGSTGTPKGVAVSHGPLAAHCQATAERYGLTPGDRELQFAS-FNFDGAHEQLLPPLICGACV 163
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 280 IL--THRFDPAATL-DAIEEHRAefTIGAIT---VFIALLHHADATREKLATLTKIYSGGAPIAPSVVEafRAKFGHV-I 352
Cdd:cd17649 164 VLrpDELWASADELaEMVRELGV--TVLDLPpayLQQLAEEADRTGDGRPPSLRLYIFGGEALSPELLR--RWLKAPVrL 239
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 353 HGAYGLTETN-SPTHMVPLARTAPVDPhsgALAMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWNNAAATA 431
Cdd:cd17649 240 FNAYGPTEATvTPLVWKCEAGAARAGA---SMPIGRPLGGRSAYILDADLNPVPVGVTGELYIGGEGLARGYLGRPELTA 316
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 432 DAF-------RGG-WFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPyRGETVK 503
Cdd:cd17649 317 ERFvpdpfgaPGSrLYRTGDLARWRDDGVIEYLGRVDHQVKIRGFRIELGEIEAALLEHPGVREAAVVALDGA-GGKQLV 395
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*
gi 1595048490 504 AVVSLRAGAV--ADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:cd17649 396 AYVVLRAAAAqpELRAQLRTALRASLPDYMVPAHLVFLARLPLTPNGKLDRKALP 450
|
|
| LC_FACS_bac1 |
cd17641 |
bacterial long-chain fatty acid CoA synthetase; The members of this family are bacterial ... |
54-518 |
7.64e-41 |
|
bacterial long-chain fatty acid CoA synthetase; The members of this family are bacterial long-chain fatty acid CoA synthetase, most of which are as yet uncharacterized. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.
Pssm-ID: 341296 [Multi-domain] Cd Length: 569 Bit Score: 155.66 E-value: 7.64e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 54 WQALdAWSD------RIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVL 127
Cdd:cd17641 9 WQEF-TWADyadrvrAFALGLLALGVGRGDVVAILGDNRPEWVWAELAAQAIGALSLGIYQDSMAEEVAYLLNYTGARVV 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 128 ICDaalEGEVVREVIaSIEAEGNAAPRVFTTRARALQTRDDPR------VFGTQREASGAGEGARDLLQAAqavqpgRKP 201
Cdd:cd17641 88 IAE---DEEQVDKLL-EIADRIPSVRYVIYCDPRGMRKYDDPRlisfedVVALGRALDRRDPGLYEREVAA------GKG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 202 ppvvlaaSDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLVGHIGAAWIARapLIL 281
Cdd:cd17641 158 -------EDVAVLCTTSGTTGKPKLAMLSHGNFLGHCAAYLAADPLGPGDEYVSVLPLPWIGEQMYSVGQALVCG--FIV 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 282 THRFDPAATLDAIEEHRAEFTIGAITVFIALLHH-----ADATREK---------------------------------- 322
Cdd:cd17641 229 NFPEEPETMMEDLREIGPTFVLLPPRVWEGIAADvrarmMDATPFKrfmfelgmklglraldrgkrgrpvslwlrlaswl 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 323 --------------LATLTKIYSGGAPIAPSVVEAFRAkFGHVIHGAYGLTETNSPThmvPLARTAPVDPHSgalaMGVP 388
Cdd:cd17641 309 adallfrplrdrlgFSRLRSAATGGAALGPDTFRFFHA-IGVPLKQLYGQTELAGAY---TVHRDGDVDPDT----VGVP 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 389 VPGAEAAIVdddgnmlaagETGEIVCRGPMVVPGYWNNAAATADAF-RGGWFHTGDVGFMDEAGWFYLVDRKKDMINAA- 466
Cdd:cd17641 381 FPGTEVRID----------EVGEILVRSPGVFVGYYKNPEATAEDFdEDGWLHTGDAGYFKENGHLVVIDRAKDVGTTSd 450
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|..
gi 1595048490 467 GYKVWPREVEDVLYGHPAVREAAVVGVPDPYrgetVKAVVSLRAGAVADAAE 518
Cdd:cd17641 451 GTRFSPQFIENKLKFSPYIAEAVVLGAGRPY----LTAFICIDYAIVGKWAE 498
|
|
| A_NRPS_GliP_like |
cd17653 |
nonribosomal peptide synthase GliP-like; This family includes the adenylation (A) domain of ... |
30-556 |
1.78e-40 |
|
nonribosomal peptide synthase GliP-like; This family includes the adenylation (A) domain of nonribosomal peptide synthases (NRPS) gliotoxin biosynthesis protein P (GliP), thioclapurine biosynthesis protein P (tcpP) and Sirodesmin biosynthesis protein P (SirP). In the filamentous fungus Aspergillus fumigatus, NRPS GliP is involved in the biosynthesis of gliotoxin, which is initiated by the condensation of serine and phenylalanine. Studies show that GliP is not required for invasive aspergillosis, suggesting that the principal targets of gliotoxin are neutrophils or other phagocytes. SirP is a phytotoxin produced by the fungus Leptosphaeria maculans, which causes blackleg disease of canola (Brassica napus). In the fungus Claviceps purpurea, NRPS tcpP catalyzes condensation of tyrosine and glycine, part of biosynthesis of an unusual class of epipolythiodioxopiperazines (ETPs) that lacks the reactive thiol group for toxicity. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341308 [Multi-domain] Cd Length: 433 Bit Score: 152.08 E-value: 1.78e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 30 DMFAAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPM 109
Cdd:cd17653 1 DAFERIAAAHPDAVAVESLGGSLTYGELDAASNALANRLLQLGVVPGDVVPLLSDRSLEMLVAILAILKAGAAYVPLDAK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 110 NRARELKLLLDDSQARVLICDAAlegevvreviasieaegnaaprvfttraralqtrddprvfgtqreasgagegardll 189
Cdd:cd17653 81 LPSARIQAILRTSGATLLLTTDS--------------------------------------------------------- 103
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 190 qaaqavqpgrkpppvvlaASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVA-PLFHITglVGH 268
Cdd:cd17653 104 ------------------PDDLAYIIFTSGSTGIPKGVMVPHRGVLNYVSQPPARLDVGPGSRVAQVLsIAFDAC--IGE 163
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 269 IGAAWIARAPLILThrfDPAATLDAIEehrAEFTIGAIT-VFIALLHHADatrekLATLTKIYSGGAPIAPSVVEAFRak 347
Cdd:cd17653 164 IFSTLCNGGTLVLA---DPSDPFAHVA---RTVDALMSTpSILSTLSPQD-----FPNLKTIFLGGEAVPPSLLDRWS-- 230
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 348 FGHVIHGAYGLTETnspTHMVPLARTAPVDPhsgaLAMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWNNA 427
Cdd:cd17653 231 PGRRLYNAYGPTEC---TISSTMTELLPGQP----VTIGKPIPNSTCYILDADLQPVPEGVVGEICISGVQVARGYLGNP 303
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 428 AATADAFRGGWFH-------TGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYG-HPAVREAAVVGVPDpyrg 499
Cdd:cd17653 304 ALTASKFVPDPFWpgsrmyrTGDYGRWTEDGGLEFLGREDNQVKVRGFRINLEEIEEVVLQsQPEVTQAAAIVVNG---- 379
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*..
gi 1595048490 500 etvkAVVSLRAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:cd17653 380 ----RLVAFVTPETVDVDGLRSELAKHLPSYAVPDRIIALDSFPLTANGKVDRKALR 432
|
|
| ttLC_FACS_like |
cd05915 |
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes ... |
47-556 |
1.23e-39 |
|
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes fatty acyl-CoA synthetases that can activate medium-chain to long-chain fatty acids. They catalyze the ATP-dependent acylation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. Fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters. The fatty acyl-CoA synthetase from Thermus thermophiles in this family has been shown to catalyze the long-chain fatty acid, myristoyl acid, while another member in this family, the AlkK protein identified in Pseudomonas oleovorans, targets medium chain fatty acids. This family also includes an uncharacterized subgroup of FACS.
Pssm-ID: 213283 [Multi-domain] Cd Length: 509 Bit Score: 151.43 E-value: 1.23e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 47 YFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARV 126
Cdd:cd05915 20 GEVHRTTYAEVYQRARRLMGGLRALGVGVGDRVATLGFNHFRHLEAYFAVPGMGAVLHTANPRLSPKEIAYILNHAEDKV 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 127 LICDAalEGEVVREVIASIEAEGNAAPrvfTTRARAlqtrddprvfgtqreasgagEGARDLLQAAQavqPGRKP-PPVv 205
Cdd:cd05915 100 LLFDP--NLLPLVEAIRGELKTVQHFV---VMDEKA--------------------PEGYLAYEEAL---GEEADpVRV- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 206 lAASDPAMLVYTSGTSGRPKGAICTHGNfAFNSQTYRDFCGLREGGPI---LGVAPLFHITGLVGHIGAAWIARAPLILT 282
Cdd:cd05915 151 -PERAACGMAYTTGTTGLPKGVVYSHRA-LVLHSLAASLVDGTALSEKdvvLPVVPMFHVNAWCLPYAATLVGAKQVLPG 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 283 HRFDPAATLDAIEEHRAEFTIGAITVFIALLHHADATREKLATLTKIYSGGAPiAPSVVEAFRAKFGHVIHGAYGLTET- 361
Cdd:cd05915 229 PRLDPASLVELFDGEGVTFTAGVPTVWLALADYLESTGHRLKTLRRLVVGGSA-APRSLIARFERMGVEVRQGYGLTETs 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 362 --NSPTHMVPLARTAPVDPHSGALAMGVPVPGAEAAIVDDDGNMLAA--GETGEIVC-RGPMVVPGYWNNAAAT-ADAFR 435
Cdd:cd05915 308 pvVVQNFVKSHLESLSEEEKLTLKAKTGLPIPLVRLRVADEEGRPVPkdGKALGEVQlKGPWITGGYYGNEEATrSALTP 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 436 GGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAgAVAD 515
Cdd:cd05915 388 DGFFRTGDIAVWDEEGYVEIKDRLKDLIKSGGEWISSVDLENALMGHPKVKEAAVVAIPHPKWQERPLAVVVPRG-EKPT 466
|
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 1595048490 516 AAELIAFCKARMAAYKY-PRIVEFRDELPKTATGKILRRELR 556
Cdd:cd05915 467 PEELNEHLLKAGFAKWQlPDAYVFAEEIPRTSAGKFLKRALR 508
|
|
| PRK12316 |
PRK12316 |
peptide synthase; Provisional |
1-555 |
2.32e-39 |
|
peptide synthase; Provisional
Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 154.73 E-value: 2.32e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 1 MNAYERFPWRALYDTGIEPNPQQEYTNGLdmFAAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVA 80
Cdd:PRK12316 1980 LDAGERQRILADWDRTPEAYPRGPGVHQR--IAEQAARAPEAIAVVFGDQHLSYAELDSRANRLAHRLRARGVGPEVRVA 2057
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 81 LYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLICDAALEGEV-VREVIASIEAEgnaaprvfttr 159
Cdd:PRK12316 2058 IAAERSFELVVALLAVLKAGGAYVPLDPNYPAERLAYMLEDSGAALLLTQRHLLERLpLPAGVARLPLD----------- 2126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 160 aRALQTRDDPRvfgtqreasgagegardllqaaqavqpgrKPPPVVLAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQ 239
Cdd:PRK12316 2127 -RDAEWADYPD-----------------------------TAPAVQLAGENLAYVIYTSGSTGLPKGVAVSHGALVAHCQ 2176
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 240 TYRDFCGLREGGPILGVAPlFHITGLVGHIGAAWIARAPLIL---THRfDPAATLDAIEEHRAefTIGAI--TVFIALLH 314
Cdd:PRK12316 2177 AAGERYELSPADCELQFMS-FSFDGAHEQWFHPLLNGARVLIrddELW-DPEQLYDEMERHGV--TILDFppVYLQQLAE 2252
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 315 HADATREKLATLTKIYSGGAPIAPSVVEAFRAKFGHVIHGAYGLTETNspthMVPLARTA-PVDPHSGALA-MGVPVPGA 392
Cdd:PRK12316 2253 HAERDGRPPAVRVYCFGGEAVPAASLRLAWEALRPVYLFNGYGPTEAV----VTPLLWKCrPQDPCGAAYVpIGRALGNR 2328
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 393 EAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWNNAAATADAF-------RGG-WFHTGDVGFMDEAGWFYLVDRKKDMIN 464
Cdd:PRK12316 2329 RAYILDADLNLLAPGMAGELYLGGEGLARGYLNRPGLTAERFvpdpfsaSGErLYRTGDLARYRADGVVEYLGRIDHQVK 2408
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 465 AAGYKVWPREVEDVLYGHPAVREAAVVGVpDPYRGETVKAVVSLRAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPK 544
Cdd:PRK12316 2409 IRGFRIELGEIEARLQAHPAVREAVVVAQ-DGASGKQLVAYVVPDDAAEDLLAELRAWLAARLPAYMVPAHWVVLERLPL 2487
|
570
....*....|.
gi 1595048490 545 TATGKILRREL 555
Cdd:PRK12316 2488 NPNGKLDRKAL 2498
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
210-550 |
6.86e-39 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 152.77 E-value: 6.86e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 210 DPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLVghiGAAWIaraPLIL-----THR 284
Cdd:PRK08633 783 DTATIIFSSGSEGEPKGVMLSHHNILSNIEQISDVFNLRNDDVILSSLPFFHSFGLT---VTLWL---PLLEgikvvYHP 856
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 285 fDP---AATLDAIEEHRAEFTIGAITVFIALLHHADATREKLATLTKIYSGGAPIAPSVVEAFRAKFGHVIHGAYGLTET 361
Cdd:PRK08633 857 -DPtdaLGIAKLVAKHRATILLGTPTFLRLYLRNKKLHPLMFASLRLVVAGAEKLKPEVADAFEEKFGIRILEGYGATET 935
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 362 nSPTHMV--PLARTAPVDPHSGALA--MGVPVPGAEAAIVD-DDGNMLAAGETGEIVCRGPMVVPGYWNNAAATADAFR- 435
Cdd:PRK08633 936 -SPVASVnlPDVLAADFKRQTGSKEgsVGMPLPGVAVRIVDpETFEELPPGEDGLILIGGPQVMKGYLGDPEKTAEVIKd 1014
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 436 ---GGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLygHPAVREA----AVVGVPDPYRGETVKAVVSL 508
Cdd:PRK08633 1015 idgIGWYVTGDKGHLDEDGFLTITDRYSRFAKIGGEMVPLGAVEEEL--AKALGGEevvfAVTAVPDEKKGEKLVVLHTC 1092
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1595048490 509 RAGAVADAAELIAfcKARMAAYKYP-RIVEFrDELPKTATGKI 550
Cdd:PRK08633 1093 GAEDVEELKRAIK--ESGLPNLWKPsRYFKV-EALPLLGSGKL 1132
|
|
| PRK12316 |
PRK12316 |
peptide synthase; Provisional |
31-555 |
6.25e-38 |
|
peptide synthase; Provisional
Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 150.11 E-value: 6.25e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 31 MFAAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMN 110
Cdd:PRK12316 4556 LVAERARMTPDAVAVVFDEEKLTYAELNRRANRLAHALIARGVGPEVLVGIAMERSAEMMVGLLAVLKAGGAYVPLDPEY 4635
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 111 RARELKLLLDDSQARVLIcdaalegevvreviasieaegnaaprvftTRARALQtrddprvfgtqREASGAGEGARDLLQ 190
Cdd:PRK12316 4636 PRERLAYMMEDSGAALLL-----------------------------TQSHLLQ-----------RLPIPDGLASLALDR 4675
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 191 AAQAVQPGRKPPPVVLAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPL-FHITGLVGHI 269
Cdd:PRK12316 4676 DEDWEGFPAHDPAVRLHPDNLAYVIYTSGSTGRPKGVAVSHGSLVNHLHATGERYELTPDDRVLQFMSFsFDGSHEGLYH 4755
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 270 GAAWIARAPLILTHRFDPAATLDAIEEHRAEFTIGAITVFIALLHHADATREkLATLTKIYSGGAPIAP-SVVEAFRAKF 348
Cdd:PRK12316 4756 PLINGASVVIRDDSLWDPERLYAEIHEHRVTVLVFPPVYLQQLAEHAERDGE-PPSLRVYCFGGEAVAQaSYDLAWRALK 4834
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 349 GHVIHGAYGLTETNspthMVPLARTAPVDPHSGALAM--GVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWNN 426
Cdd:PRK12316 4835 PVYLFNGYGPTETT----VTVLLWKARDGDACGAAYMpiGTPLGNRSGYVLDGQLNPLPVGVAGELYLGGEGVARGYLER 4910
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 427 AAATADAF-------RGG-WFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYR 498
Cdd:PRK12316 4911 PALTAERFvpdpfgaPGGrLYRTGDLARYRADGVIDYLGRVDHQVKIRGFRIELGEIEARLREHPAVREAVVIAQEGAVG 4990
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1595048490 499 GETVKAVVSlRAGAVADAAELIAFCKARMAA--------YKYPRIVEFRDELPKTATGKILRREL 555
Cdd:PRK12316 4991 KQLVGYVVP-QDPALADADEAQAELRDELKAalrerlpeYMVPAHLVFLARMPLTPNGKLDRKAL 5054
|
|
| FADD10 |
cd17635 |
adenylate forming domain, fatty acid CoA ligase (FadD10); This family contains long chain ... |
209-552 |
4.78e-37 |
|
adenylate forming domain, fatty acid CoA ligase (FadD10); This family contains long chain fatty acid CoA ligases, including FadD10 which is involved in the synthesis of a virulence-related lipopeptide. FadD10 is a fatty acyl-AMP ligase (FAAL) that transfers fatty acids to an acyl carrier protein. Structures of FadD10 in apo- and complexed form with dodecanoyl-AMP, show a novel open conformation, facilitated by its unique inter-domain and intermolecular interactions, which is critical for the enzyme to carry out the acyl transfer onto the acyl carrier protein (Rv0100) rather than coenzyme A.
Pssm-ID: 341290 [Multi-domain] Cd Length: 340 Bit Score: 140.47 E-value: 4.78e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 209 SDPAMLVYTSGTSGRPKGAICTHGNFaFNSQTYRDFCGLREGGPILGVAPLfHITglvgHIGAAWIARAPLILT------ 282
Cdd:cd17635 1 EDPLAVIFTSGTTGEPKAVLLANKTF-FAVPDILQKEGLNWVVGDVTYLPL-PAT----HIGGLWWILTCLIHGglcvtg 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 283 -HRFDPAATLDAIEEHRAEFTI---GAITVFIALLHHADATREKLATLtkIYSGGAPIAPSVveAFRAKFGHV-IHGAYG 357
Cdd:cd17635 75 gENTTYKSLFKILTTNAVTTTClvpTLLSKLVSELKSANATVPSLRLI--GYGGSRAIAADV--RFIEATGLTnTAQVYG 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 358 LTETNSPTHMvplartapvDPHSGAL---AMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWNNAAATADAF 434
Cdd:cd17635 151 LSETGTALCL---------PTDDDSIeinAVGRPYPGVDVYLAATDGIAGPSASFGTIWIKSPANMLGYWNNPERTAEVL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 435 RGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVA 514
Cdd:cd17635 222 IDGWVNTGDLGERREDGFLFITGRSSESINCGGVKIAPDEVERIAEGVSGVQECACYEISDEEFGELVGLAVVASAELDE 301
|
330 340 350
....*....|....*....|....*....|....*....
gi 1595048490 515 DAAE-LIAFCKARMAAYKYPRIVEFRDELPKTATGKILR 552
Cdd:cd17635 302 NAIRaLKHTIRRELEPYARPSTIVIVTDIPRTQSGKVKR 340
|
|
| hsFATP2a_ACSVL_like |
cd05938 |
Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar ... |
49-555 |
7.45e-37 |
|
Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar proteins; Fatty acid transport proteins (FATP) of this family transport long-chain or very-long-chain fatty acids across the plasma membrane. At least five copies of FATPs are identified in mammalian cells. This family includes hsFATP2, hsFATP5, and hsFATP6, and similar proteins. Each FATP has unique patterns of tissue distribution. These FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. The hsFATP proteins exist in two splice variants; the b variant, lacking exon 3, has no acyl-CoA synthetase activity. FATPs are key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis.
Pssm-ID: 341261 [Multi-domain] Cd Length: 537 Bit Score: 143.59 E-value: 7.45e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 49 DGRLDWQALDAWSDRIACLLLDE-GVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVL 127
Cdd:cd05938 3 GETYTYRDVDRRSNQAARALLAHaGLRPGDTVALLLGNEPAFLWIWLGLAKLGCPVAFLNTNIRSKSLLHCFRCCGAKVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 128 ICDAALEgEVVREVIASIEAEGnaaprvfttraralqtrddPRVFGTQREASgaGEGARDLLQAAQAVQPgrKPPPVVLA 207
Cdd:cd05938 83 VVAPELQ-EAVEEVLPALRADG-------------------VSVWYLSHTSN--TEGVISLLDKVDAASD--EPVPASLR 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 208 A----SDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRdFCGLREGGPILGVAPLFHITGLVGHIGAAWIARAPLILTH 283
Cdd:cd05938 139 AhvtiKSPALYIYTSGTTGLPKAARISHLRVLQCSGFLS-LCGVTADDVIYITLPLYHSSGFLLGIGGCIELGATCVLKP 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 284 RFDPAATLDAIEEHRaeftigaITVF--IALL--------------HHadatREKLATltkiysgGAPIAPSVVEAFRAK 347
Cdd:cd05938 218 KFSASQFWDDCRKHN-------VTVIqyIGELlrylcnqpqspndrDH----KVRLAI-------GNGLRADVWREFLRR 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 348 FGHV-IHGAYGLTETNSPThMVPLARTAPVDPHSGALAMGVPV------PGAEAAIVDDDGNMLAA--GETGEIVCRGPM 418
Cdd:cd05938 280 FGPIrIREFYGSTEGNIGF-FNYTGKIGAVGRVSYLYKLLFPFelikfdVEKEEPVRDAQGFCIPVakGEPGLLVAKITQ 358
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 419 VVP--GYWNNAAAT-----ADAFRGG--WFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAA 489
Cdd:cd05938 359 QSPflGYAGDKEQTekkllRDVFKKGdvYFNTGDLLVQDQQNFLYFHDRVGDTFRWKGENVATTEVADVLGLLDFLQEVN 438
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1595048490 490 VVGVPDP-YRGETVKAVVSLRAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRREL 555
Cdd:cd05938 439 VYGVTVPgHEGRIGMAAVKLKPGHEFDGKKLYQHVREYLPAYARPRFLRIQDSLEITGTFKQQKVRL 505
|
|
| A_NRPS_SidN3_like |
cd05918 |
The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); ... |
30-556 |
1.09e-36 |
|
The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. This family of siderophore-synthesizing NRPS includes the third adenylation domain of SidN from the endophytic fungus Neotyphodium lolii, ferrichrome siderophore synthetase, HC-toxin synthetase, and enniatin synthase. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341242 [Multi-domain] Cd Length: 481 Bit Score: 142.30 E-value: 1.09e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 30 DMFAAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPM 109
Cdd:cd05918 3 DLIEERARSQPDAPAVCAWDGSLTYAELDRLSSRLAHHLRSLGVGPGVFVPLCFEKSKWAVVAMLAVLKAGGAFVPLDPS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 110 NRARELKLLLDDSQARVLICDAAlegevvreviasieaegnaaprvfttraralqtrddprvfgtqreasgagegardll 189
Cdd:cd05918 83 HPLQRLQEILQDTGAKVVLTSSP--------------------------------------------------------- 105
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 190 qaaqavqpgrkpppvvlaaSDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPL-FHITglVGH 268
Cdd:cd05918 106 -------------------SDAAYVIFTSGSTGKPKGVVIEHRALSTSALAHGRALGLTSESRVLQFASYtFDVS--ILE 164
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 269 IGAAWIARAPLILTHRFDPAATL-DAIEEHRAefTIGAIT-VFIALLHHADatrekLATLTKIYSGGAPIAPSVVEAFRa 346
Cdd:cd05918 165 IFTTLAAGGCLCIPSEEDRLNDLaGFINRLRV--TWAFLTpSVARLLDPED-----VPSLRTLVLGGEALTQSDVDTWA- 236
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 347 kfGHV-IHGAYGLTETNspthmvPLARTAPVDPHSGALAMGVPVPGAeAAIVD-DDGNMLAA-GETGEIVCRGPMVVPGY 423
Cdd:cd05918 237 --DRVrLINAYGPAECT------IAATVSPVVPSTDPRNIGRPLGAT-CWVVDpDNHDRLVPiGAVGELLIEGPILARGY 307
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 424 WNNAAATADAF-------------RGGWF-HTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAA 489
Cdd:cd05918 308 LNDPEKTAAAFiedpawlkqegsgRGRRLyRTGDLVRYNPDGSLEYVGRKDTQVKIRGQRVELGEIEHHLRQSLPGAKEV 387
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 490 VVGVPDPYRGETVK---AVVSLRAG-----------------AVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGK 549
Cdd:cd05918 388 VVEVVKPKDGSSSPqlvAFVVLDGSssgsgdgdslflepsdeFRALVAELRSKLRQRLPSYMVPSVFLPLSHLPLTASGK 467
|
....*..
gi 1595048490 550 ILRRELR 556
Cdd:cd05918 468 IDRRALR 474
|
|
| prpE |
PRK10524 |
propionyl-CoA synthetase; Provisional |
63-556 |
1.45e-36 |
|
propionyl-CoA synthetase; Provisional
Pssm-ID: 182517 [Multi-domain] Cd Length: 629 Bit Score: 143.94 E-value: 1.45e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 63 RIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLIC-DAALEGevvrev 141
Cdd:PRK10524 96 RMAAMLRSLGVQRGDRVLIYMPMIAEAAFAMLACARIGAIHSVVFGGFASHSLAARIDDAKPVLIVSaDAGSRG------ 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 142 iasieaeGNAAP-RVFTTRARALQTRDDPRVFGTQRE-ASGAGEGARDLLQAA-QAVQPGRKPPPVVLAASDPAMLVYTS 218
Cdd:PRK10524 170 -------GKVVPyKPLLDEAIALAQHKPRHVLLVDRGlAPMARVAGRDVDYATlRAQHLGARVPVEWLESNEPSYILYTS 242
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 219 GTSGRPKGAICTHGNFAFNSQTYRD--FCGlREGGPILGVAplfHITGLVGHigaAWIARAPLI----------LTHRFD 286
Cdd:PRK10524 243 GTTGKPKGVQRDTGGYAVALATSMDtiFGG-KAGETFFCAS---DIGWVVGH---SYIVYAPLLagmatimyegLPTRPD 315
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 287 PAATLDAIEEHRAEFTIGAITVFIALLHHADA--TREKLATLTKIYSGGAPIAPSVVEAFRAKFGHVIHGAYGLTETNSP 364
Cdd:PRK10524 316 AGIWWRIVEKYKVNRMFSAPTAIRVLKKQDPAllRKHDLSSLRALFLAGEPLDEPTASWISEALGVPVIDNYWQTETGWP 395
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 365 thMVPLARTAPVDPH-SGAlaMGVPVPGAEAAIVDD-DGNMLAAGETGEIVCRGPMVvPG---------------YWNna 427
Cdd:PRK10524 396 --ILAIARGVEDRPTrLGS--PGVPMYGYNVKLLNEvTGEPCGPNEKGVLVIEGPLP-PGcmqtvwgdddrfvktYWS-- 468
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 428 aatadAFRGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVS 507
Cdd:PRK10524 469 -----LFGRQVYSTFDWGIRDADGYYFILGRTDDVINVAGHRLGTREIEESISSHPAVAEVAVVGVKDALKGQVAVAFVV 543
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*..
gi 1595048490 508 LRAGAVAD--------AAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:PRK10524 544 PKDSDSLAdrearlalEKEIMALVDSQLGAVARPARVWFVSALPKTRSGKLLRRAIQ 600
|
|
| LC_FACS_bac |
cd05932 |
Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter ... |
63-518 |
3.46e-36 |
|
Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; The members of this family are bacterial long-chain fatty acid CoA synthetase. Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase in this family is involved in the synthesis of isoprenoid wax ester storage compounds when grown on phytol as the sole carbon source. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.
Pssm-ID: 341255 [Multi-domain] Cd Length: 508 Bit Score: 141.45 E-value: 3.46e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 63 RIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLIcdaalegevvrevI 142
Cdd:cd05932 18 RLAAALRALGLEPGSKIALISKNCAEWFITDLAIWMAGHISVPLYPTLNPDTIRYVLEHSESKALF-------------V 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 143 ASIEAEGNAAPRVFTTRARALQTRDDPRVFGTQREAsgagegardlLQAAQAVQPGRKPPpvvlAASDPAMLVYTSGTSG 222
Cdd:cd05932 85 GKLDDWKAMAPGVPEGLISISLPPPSAANCQYQWDD----------LIAQHPPLEERPTR----FPEQLATLIYTSGTTG 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 223 RPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLVghigaaWIARAPLILTHRFDPAATLDA----IEEHR 298
Cdd:cd05932 151 QPKGVMLTFGSFAWAAQAGIEHIGTEENDRMLSYLPLAHVTERV------FVEGGSLYGGVLVAFAESLDTfvedVQRAR 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 299 AEFTIGAITVFIALLH--HADATREKLATLTKI-----------------------YSGGAPIAPSVVEAFRaKFGHVIH 353
Cdd:cd05932 225 PTLFFSVPRLWTKFQQgvQDKIPQQKLNLLLKIpvvnslvkrkvlkglgldqcrlaGCGSAPVPPALLEWYR-SLGLNIL 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 354 GAYGLTETNSPTHMvplarTAPVDPHSGALamGVPVPGAEAAIvdddgnmlaaGETGEIVCRGPMVVPGYWNNAAATADA 433
Cdd:cd05932 304 EAYGMTENFAYSHL-----NYPGRDKIGTV--GNAGPGVEVRI----------SEDGEILVRSPALMMGYYKDPEATAEA 366
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 434 FRG-GWFHTGDVGFMDEAGWFYLVDRKKDMINAA-GYKVWPREVEDVLYGHPAVREAAVVG--VPDPYrgetvkAVVSLR 509
Cdd:cd05932 367 FTAdGFLRTGDKGELDADGNLTITGRVKDIFKTSkGKYVAPAPIENKLAEHDRVEMVCVIGsgLPAPL------ALVVLS 440
|
....*....
gi 1595048490 510 AGAVADAAE 518
Cdd:cd05932 441 EEARLRADA 449
|
|
| PRK00174 |
PRK00174 |
acetyl-CoA synthetase; Provisional |
63-556 |
7.60e-36 |
|
acetyl-CoA synthetase; Provisional
Pssm-ID: 234677 [Multi-domain] Cd Length: 637 Bit Score: 141.82 E-value: 7.60e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 63 RIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLIC------------- 129
Cdd:PRK00174 110 RFANALKSLGVKKGDRVAIYMPMIPEAAVAMLACARIGAVHSVVFGGFSAEALADRIIDAGAKLVITadegvrggkpipl 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 130 ----DAALEG-EVVREVIasieaegnaaprVFttraralqtrddpRVFGtqreASGAGEGARDL----LQAAQAVQPgrk 200
Cdd:PRK00174 190 kanvDEALANcPSVEKVI------------VV-------------RRTG----GDVDWVEGRDLwwheLVAGASDEC--- 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 201 pPPVVLAASDPAMLVYTSGTSGRPKGAICTHGNFA-FNSQTYRDFCGLREGgpilgvaPLFHITGLVGHI-GAAWIARAP 278
Cdd:PRK00174 238 -EPEPMDAEDPLFILYTSGSTGKPKGVLHTTGGYLvYAAMTMKYVFDYKDG-------DVYWCTADVGWVtGHSYIVYGP 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 279 LIL---------------THRFdpaatLDAIEEHRaeftigaITVF------I-ALLHHADA--TREKLATLTKIYSGGA 334
Cdd:PRK00174 310 LANgattlmfegvpnypdPGRF-----WEVIDKHK-------VTIFytaptaIrALMKEGDEhpKKYDLSSLRLLGSVGE 377
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 335 PIAPSVVEAFRAKFGH---VIHGAYGLTETNSptHMV-PLARTAPVDPHSGALamgvPVPGAEAAIVDDDGNMLAAGETG 410
Cdd:PRK00174 378 PINPEAWEWYYKVVGGercPIVDTWWQTETGG--IMItPLPGATPLKPGSATR----PLPGIQPAVVDEEGNPLEGGEGG 451
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 411 EIVCRGPMvvPG---------------YWNnaaatadAFRGGWFhTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREV 475
Cdd:PRK00174 452 NLVIKDPW--PGmmrtiygdherfvktYFS-------TFKGMYF-TGDGARRDEDGYYWITGRVDDVLNVSGHRLGTAEI 521
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 476 EDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVADAA---ELIAFCKARMAAYKYPRIVEFRDELPKTATGKILR 552
Cdd:PRK00174 522 ESALVAHPKVAEAAVVGRPDDIKGQGIYAFVTLKGGEEPSDElrkELRNWVRKEIGPIAKPDVIQFAPGLPKTRSGKIMR 601
|
....
gi 1595048490 553 RELR 556
Cdd:PRK00174 602 RILR 605
|
|
| entE |
PRK10946 |
(2,3-dihydroxybenzoyl)adenylate synthase; |
38-556 |
1.16e-35 |
|
(2,3-dihydroxybenzoyl)adenylate synthase;
Pssm-ID: 236803 [Multi-domain] Cd Length: 536 Bit Score: 140.13 E-value: 1.16e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 38 RAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGavMVPVNPM--NRAREL 115
Cdd:PRK10946 35 AASDAIAVICGERQFSYRELNQASDNLACSLRRQGIKPGDTALVQLGNVAEFYITFFALLKLG--VAPVNALfsHQRSEL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 116 KLLLDDSQARVLICDAALE----GEVVREVIASIEAEgnaaprvfttraRALQTRDDPrvfgtqreasgageGARDLLQA 191
Cdd:PRK10946 113 NAYASQIEPALLIADRQHAlfsdDDFLNTLVAEHSSL------------RVVLLLNDD--------------GEHSLDDA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 192 AQAVQPGRKPPPVvlAASDPAMLVYTSGTSGRPKGAICTHGNF-----------AFNSQTyRDFCGLreggPI------- 253
Cdd:PRK10946 167 INHPAEDFTATPS--PADEVAFFQLSGGSTGTPKLIPRTHNDYyysvrrsveicGFTPQT-RYLCAL----PAahnypms 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 254 ----LGVaplFHITGLVghigaawiaraplILTHrfDPAATL--DAIEEHRAEFTI---GAITVFIALLHHADAtREKLA 324
Cdd:PRK10946 240 spgaLGV---FLAGGTV-------------VLAP--DPSATLcfPLIEKHQVNVTAlvpPAVSLWLQAIAEGGS-RAQLA 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 325 TLTKIYSGGAPIAPSVVEAFRAKFGHVIHGAYGLTETnspthMVPLARTAPVDPHSgALAMGVPV-PGAEAAIVDDDGNM 403
Cdd:PRK10946 301 SLKLLQVGGARLSETLARRIPAELGCQLQQVFGMAEG-----LVNYTRLDDSDERI-FTTQGRPMsPDDEVWVADADGNP 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 404 LAAGETGEIVCRGPMVVPGYWNNAAATADAF-RGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGH 482
Cdd:PRK10946 375 LPQGEVGRLMTRGPYTFRGYYKSPQHNASAFdANGFYCSGDLVSIDPDGYITVVGREKDQINRGGEKIAAEEIENLLLRH 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 483 PAVREAAVVGVPDPYRGET----------VKAVV---SLRAGAVADaaeliafckarmaaYKYPRIVEFRDELPKTATGK 549
Cdd:PRK10946 455 PAVIHAALVSMEDELMGEKscaflvvkepLKAVQlrrFLREQGIAE--------------FKLPDRVECVDSLPLTAVGK 520
|
....*..
gi 1595048490 550 ILRRELR 556
Cdd:PRK10946 521 VDKKQLR 527
|
|
| PRK12467 |
PRK12467 |
peptide synthase; Provisional |
31-555 |
1.57e-35 |
|
peptide synthase; Provisional
Pssm-ID: 237108 [Multi-domain] Cd Length: 3956 Bit Score: 142.99 E-value: 1.57e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 31 MFAAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMN 110
Cdd:PRK12467 3100 LIEAQVARTPEAPALVFGDQQLSYAELNRRANRLAHRLIAIGVGPDVLVGVAVERSVEMIVALLAVLKAGGAYVPLDPEY 3179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 111 RARELKLLLDDSQARVLIcdaalegevvreviasieaegnaaprvftTRARALQTRddPRVfgtqreasgAGEGARDLLQ 190
Cdd:PRK12467 3180 PRERLAYMIEDSGVKLLL-----------------------------TQAHLLEQL--PAP---------AGDTALTLDR 3219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 191 AAQAVQPGRKPPPVVLAASdPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPlFHITGLVGHIG 270
Cdd:PRK12467 3220 LDLNGYSENNPSTRVMGEN-LAYVIYTSGSTGKPKGVGVRHGALANHLCWIAEAYELDANDRVLLFMS-FSFDGAQERFL 3297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 271 AAWIARAPLILT--HRFDPAATLDAIEEHR---AEFTIGAITVFIallhhADATREKLATLTKIYSGGAPIAPSVVEAFR 345
Cdd:PRK12467 3298 WTLICGGCLVVRdnDLWDPEELWQAIHAHRisiACFPPAYLQQFA-----EDAGGADCASLDIYVFGGEAVPPAAFEQVK 3372
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 346 AKFGHV-IHGAYGLTETNspthMVPLARTAPVD--PHSGALAMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPG 422
Cdd:PRK12467 3373 RKLKPRgLTNGYGPTEAV----VTVTLWKCGGDavCEAPYAPIGRPVAGRSIYVLDGQLNPVPVGVAGELYIGGVGLARG 3448
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 423 YWNNAAATADAF--------RGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVp 494
Cdd:PRK12467 3449 YHQRPSLTAERFvadpfsgsGGRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIEARLLQHPSVREAVVLAR- 3527
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1595048490 495 DPYRGETVKAVVSLRAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRREL 555
Cdd:PRK12467 3528 DGAGGKQLVAYVVPADPQGDWRETLRDHLAASLPDYMVPAQLLVLAAMPLGPNGKVDRKAL 3588
|
|
| PRK09192 |
PRK09192 |
fatty acyl-AMP ligase; |
30-556 |
3.49e-35 |
|
fatty acyl-AMP ligase;
Pssm-ID: 236403 [Multi-domain] Cd Length: 579 Bit Score: 139.37 E-value: 3.49e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 30 DMFAAALERAPH-ESALLYFDGR------LDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAV 102
Cdd:PRK09192 21 PTLVEALDYAALgEAGMNFYDRRgqleeaLPYQTLRARAEAGARRLLALGLKPGDRVALIAETDGDFVEAFFACQYAGLV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 103 MVPVN-PMN---RA---RELKLLLDDSQARVLICDAALEGEVvreviasiEAEGNAAPRVFTTRARALQTRDDPRVfgtq 175
Cdd:PRK09192 101 PVPLPlPMGfggREsyiAQLRGMLASAQPAAIITPDELLPWV--------NEATHGNPLLHVLSHAWFKALPEADV---- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 176 reasgagegardllqAAQAVQPGrkpppvvlaasDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTY-RDFCGLREGGPIL 254
Cdd:PRK09192 169 ---------------ALPRPTPD-----------DIAYLQYSSGSTRFPRGVIITHRALMANLRAIsHDGLKVRPGDRCV 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 255 GVAPLFHITGLVGHIGAAWIAR--APLILTHRF--DPAATLDAIEEHRAE--------FTIGAITVFIALLHHADATREK 322
Cdd:PRK09192 223 SWLPFYHDMGLVGFLLTPVATQlsVDYLPTRDFarRPLQWLDLISRNRGTisysppfgYELCARRVNSKDLAELDLSCWR 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 323 LATLtkiysGGAPIAPSVVEAFRAKFGHVIHGA------YGLTETNSPTHMVPLAR---------------TAPVDPHSG 381
Cdd:PRK09192 303 VAGI-----GADMIRPDVLHQFAEAFAPAGFDDkafmpsYGLAEATLAVSFSPLGSgivveevdrdrleyqGKAVAPGAE 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 382 ALAM------GVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWNNAAATADAFRGGWFHTGDVGFMDEaGWFYL 455
Cdd:PRK09192 378 TRRVrtfvncGKALPGHEIEIRNEAGMPLPERVVGHICVRGPSLMSGYFRDEESQDVLAADGWLDTGDLGYLLD-GYLYI 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 456 VDRKKDMINAAGYKVWPREVEDVLYGHPAVR--EAAVVGVPDPyRGETVKAVVSLRAGAVADAAELIAFCKARM-AAYKY 532
Cdd:PRK09192 457 TGRAKDLIIINGRNIWPQDIEWIAEQEPELRsgDAAAFSIAQE-NGEKIVLLVQCRISDEERRGQLIHALAALVrSEFGV 535
|
570 580
....*....|....*....|....*.
gi 1595048490 533 PRIVEF--RDELPKTATGKILRRELR 556
Cdd:PRK09192 536 EAAVELvpPHSLPRTSSGKLSRAKAK 561
|
|
| A_NRPS_ACVS-like |
cd17648 |
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase; This family contains ACV ... |
40-555 |
9.03e-35 |
|
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase; This family contains ACV synthetase (ACVS, EC 6.3.2.26; also known as N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase or delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase) is involved in medically important antibiotic biosynthesis. ACV synthetase is active in an early step in the penicillin G biosynthesis pathway which involves the formation of the tripeptide 6-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine (ACV); each of the constituent amino acids of the tripeptide ACV are activated as aminoacyl-adenylates with peptide bonds formed through the participation of amino acid thioester intermediates. ACV is then cyclized by the action of isopenicillin N synthase.
Pssm-ID: 341303 [Multi-domain] Cd Length: 453 Bit Score: 136.38 E-value: 9.03e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 40 PHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGD-RVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLL 118
Cdd:cd17648 1 PDRVAVVYGDKRLTYRELNERANRLAHYLLSVAEIRPDdLVGLVLDKSELMIIAILAVWKAGAAYVPIDPSYPDERIQFI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 119 LDDSQARVLICDAalegevvreviasieaegnaaprvfttraralqtrddprvfgtqreasgagegardllqaaqavqpg 198
Cdd:cd17648 81 LEDTGARVVITNS------------------------------------------------------------------- 93
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 199 rkpppvvlaaSDPAMLVYTSGTSGRPKGAICTHGNfAFNSQT--YRDFCGLREGGPILGVAPLFHITGLVGHIGAAWIAR 276
Cdd:cd17648 94 ----------TDLAYAIYTSGTTGKPKGVLVEHGS-VVNLRTslSERYFGRDNGDEAVLFFSNYVFDFFVEQMTLALLNG 162
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 277 APLIL---THRFDPAATLDAIEEHRAEFTIGAITVfialLHHADATRekLATLTKIYSGGAPIAPSVVEAFRAKFGHVIH 353
Cdd:cd17648 163 QKLVVppdEMRFDPDRFYAYINREKVTYLSGTPSV----LQQYDLAR--LPHLKRVDAAGEEFTAPVFEKLRSRFAGLII 236
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 354 GAYGLTETNSPTHMVPLARTAPVDphsgaLAMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWNNAAATADA 433
Cdd:cd17648 237 NAYGPTETTVTNHKRFFPGDQRFD-----KSLGRPVRNTKCYVLNDAMKRVPVGAVGELYLGGDGVARGYLNRPELTAER 311
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 434 F------------RGGW---FHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVG--VPDP 496
Cdd:cd17648 312 FlpnpfqteqeraRGRNarlYKTGDLVRWLPSGELEYLGRNDFQVKIRGQRIEPGEVEAALASYPGVRECAVVAkeDASQ 391
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1595048490 497 YRGETVKAVVS---LRAGAVaDAAELIAFCKARMAAYKYP-RIVEFrDELPKTATGKILRREL 555
Cdd:cd17648 392 AQSRIQKYLVGyylPEPGHV-PESDLLSFLRAKLPRYMVPaRLVRL-EGIPVTINGKLDVRAL 452
|
|
| PRK07768 |
PRK07768 |
long-chain-fatty-acid--CoA ligase; Validated |
51-554 |
1.12e-34 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 236091 [Multi-domain] Cd Length: 545 Bit Score: 137.43 E-value: 1.12e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 51 RLDWQALDAWSDRIACLLLDEGVQRGDRVALyLQNVP-QFVMALLGIWKAGA--VMVPvNPMNRArELKLLLDDSQARVL 127
Cdd:PRK07768 29 RHTWGEVHERARRIAGGLAAAGVGPGDAVAV-LAGAPvEIAPTAQGLWMRGAslTMLH-QPTPRT-DLAVWAEDTLRVIG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 128 ICDAALegevvreVIASieaegnaAPrvFTTRARALqtrddprvfgtqreasgAGEGAR-----DLLQAAQAvqpgrkpP 202
Cdd:PRK07768 106 MIGAKA-------VVVG-------EP--FLAAAPVL-----------------EEKGIRvltvaDLLAADPI-------D 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 203 PVVLAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLR-EGGPILGVAPLFHITGLVGHI------GAAWIA 275
Cdd:PRK07768 146 PVETGEDDLALMQLTSGSTGSPKAVQITHGNLYANAEAMFVAAEFDvETDVMVSWLPLFHDMGMVGFLtvpmyfGAELVK 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 276 RAPLILTHrfDPAATLDAIEEHRAEFTIG---AITVFIALLHH-ADATREKLATLTKIYSGGAPIAPSVVEAFR---AKF 348
Cdd:PRK07768 226 VTPMDFLR--DPLLWAELISKYRGTMTAApnfAYALLARRLRRqAKPGAFDLSSLRFALNGAEPIDPADVEDLLdagARF 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 349 G---HVIHGAYGLTETNSPTHMVP-----------------LARTAPVD-PHSGALAM-GVPVPGAEAAIVDDDGNMLAA 406
Cdd:PRK07768 304 GlrpEAILPAYGMAEATLAVSFSPcgaglvvdevdadllaaLRRAVPATkGNTRRLATlGPPLPGLEVRVVDEDGQVLPP 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 407 GETGEIVCRGPMVVPGYWNNAAATADAFRGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVR 486
Cdd:PRK07768 384 RGVGVIELRGESVTPGYLTMDGFIPAQDADGWLDTGDLGYLTEEGEVVVCGRVKDVIIMAGRNIYPTDIERAAARVEGVR 463
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1595048490 487 E--AAVVGVPDPYRGETVKAVVSLRAGAVADAAELIafcKARMAAYKY------PRIVEF--RDELPKTATGKiLRRE 554
Cdd:PRK07768 464 PgnAVAVRLDAGHSREGFAVAVESNAFEDPAEVRRI---RHQVAHEVVaevgvrPRNVVVlgPGSIPKTPSGK-LRRA 537
|
|
| PRK07824 |
PRK07824 |
o-succinylbenzoate--CoA ligase; |
209-556 |
3.50e-34 |
|
o-succinylbenzoate--CoA ligase;
Pssm-ID: 236108 [Multi-domain] Cd Length: 358 Bit Score: 132.86 E-value: 3.50e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 209 SDPAMLVYTSGTSGRPKGAICTHGNF-AFNSQTYRdfcglREGGP--ILGVAPLFHITGLVGHIGAAWIARAPLIL--TH 283
Cdd:PRK07824 35 DDVALVVATSGTTGTPKGAMLTAAALtASADATHD-----RLGGPgqWLLALPAHHIAGLQVLVRSVIAGSEPVELdvSA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 284 RFDPAATLDAIEEHRAE--FTIGAITVFIALLHHADATrEKLATLTKIYSGGAPIAPSVVEAfRAKFGHVIHGAYGLTET 361
Cdd:PRK07824 110 GFDPTALPRAVAELGGGrrYTSLVPMQLAKALDDPAAT-AALAELDAVLVGGGPAPAPVLDA-AAAAGINVVRTYGMSET 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 362 NSpthmvplartapvdphsGALAMGVPVPGAEAAIVDddgnmlaagetGEIVCRGPMVVPGYWNnaAATADAF-RGGWFH 440
Cdd:PRK07824 188 SG-----------------GCVYDGVPLDGVRVRVED-----------GRIALGGPTLAKGYRN--PVDPDPFaEPGWFR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 441 TGDVGFMDEaGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVADAAELI 520
Cdd:PRK07824 238 TDDLGALDD-GVLTVLGRADDAISTGGLTVLPQVVEAALATHPAVADCAVFGLPDDRLGQRVVAAVVGDGGPAPTLEALR 316
|
330 340 350
....*....|....*....|....*....|....*.
gi 1595048490 521 AFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:PRK07824 317 AHVARTLDRTAAPRELHVVDELPRRGIGKVDRRALV 352
|
|
| PRK12316 |
PRK12316 |
peptide synthase; Provisional |
31-555 |
3.68e-34 |
|
peptide synthase; Provisional
Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 138.94 E-value: 3.68e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 31 MFAAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMN 110
Cdd:PRK12316 516 LFEEQVERTPEAPALAFGEETLDYAELNRRANRLAHALIERGVGPDVLVGVAMERSIEMVVALLAILKAGGAYVPLDPEY 595
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 111 RARELKLLLDDSQARVLICDAALEGEVvreviasieaegnaaprvfttraralqtrddPRVFGTQREAsgagegardlLQ 190
Cdd:PRK12316 596 PAERLAYMLEDSGVQLLLSQSHLGRKL-------------------------------PLAAGVQVLD----------LD 634
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 191 AAQAVQPGR--KPPPVVLAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPlFHITGLVGH 268
Cdd:PRK12316 635 RPAAWLEGYseENPGTELNPENLAYVIYTSGSTGKPKGAGNRHRALSNRLCWMQQAYGLGVGDTVLQKTP-FSFDVSVWE 713
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 269 IGAAWIARAPLILT---HRFDPAATLDAIEEHRAEFTIGAITVFIALLHHADAtrEKLATLTKIYSGGAPIAPSVVEAFR 345
Cdd:PRK12316 714 FFWPLMSGARLVVAapgDHRDPAKLVELINREGVDTLHFVPSMLQAFLQDEDV--ASCTSLRRIVCSGEALPADAQEQVF 791
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 346 AKF--GHVIHgAYGLTETNspthmVPLARTAPVDPHSGALAMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGY 423
Cdd:PRK12316 792 AKLpqAGLYN-LYGPTEAA-----IDVTHWTCVEEGGDSVPIGRPIANLACYILDANLEPVPVGVLGELYLAGRGLARGY 865
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 424 WNNAAATADAFRGGWF-------HTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVpdp 496
Cdd:PRK12316 866 HGRPGLTAERFVPSPFvagermyRTGDLARYRADGVIEYAGRIDHQVKLRGLRIELGEIEARLLEHPWVREAAVLAV--- 942
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*....
gi 1595048490 497 yRGETVKAVVSLRAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRREL 555
Cdd:PRK12316 943 -DGKQLVGYVVLESEGGDWREALKAHLAASLPEYMVPAQWLALERLPLTPNGKLDRKAL 1000
|
|
| A_NRPS_Bac |
cd17655 |
bacitracin synthetase and related proteins; This family of the adenylation (A) domain of ... |
31-555 |
4.58e-34 |
|
bacitracin synthetase and related proteins; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes bacitracin synthetases 1, 2, and 3 (BA1, also known as ATP-dependent cysteine adenylase or cysteine activase, BA2, also known as ATP-dependent lysine adenylase or lysine activase, and BA3, also known as ATP-dependent isoleucine adenylase or isoleucine activase) in Bacilli. Bacitracin is a mixture of related cyclic peptides used as a polypeptide antibiotic. This family also includes gramicidin synthetase 1 involved in synthesis of the cyclic peptide antibiotic gramicidin S via activation of phenylalanine. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341310 [Multi-domain] Cd Length: 490 Bit Score: 135.15 E-value: 4.58e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 31 MFAAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMN 110
Cdd:cd17655 2 LFEEQAEKTPDHTAVVFEDQTLTYRELNERANQLARTLREKGVGPDTIVGIMAERSLEMIVGILGILKAGGAYLPIDPDY 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 111 RARELKLLLDDSQARVLICDAALEgevvrEVIASIEAegnaaprvfttrarALQTRDDprvfgtqreaSGAGEGARDLlq 190
Cdd:cd17655 82 PEERIQYILEDSGADILLTQSHLQ-----PPIAFIGL--------------IDLLDED----------TIYHEESENL-- 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 191 aaqavqpgrkppPVVLAASDPAMLVYTSGTSGRPKGAICTHGNF-----AFNSQTYRDfcglrEGGPILGVAPlFHITGL 265
Cdd:cd17655 131 ------------EPVSKSDDLAYVIYTSGSTGKPKGVMIEHRGVvnlveWANKVIYQG-----EHLRVALFAS-ISFDAS 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 266 VGHIGAAWIARAPLILThRFDPAATLDAIEEHRAEFTIGAITVFIALLHHADATREKLA-TLTKIYSGGAPIAPSVVEAF 344
Cdd:cd17655 193 VTEIFASLLSGNTLYIV-RKETVLDGQALTQYIRQNRITIIDLTPAHLKLLDAADDSEGlSLKHLIVGGEALSTELAKKI 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 345 RAKFGH--VIHGAYGLTETnspthmVPLARTAPVDP---HSGALAMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMV 419
Cdd:cd17655 272 IELFGTnpTITNAYGPTET------TVDASIYQYEPetdQQVSVPIGKPLGNTRIYILDQYGRPQPVGVAGELYIGGEGV 345
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 420 VPGYWNNAAATA-----DAFRGG--WFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVG 492
Cdd:cd17655 346 ARGYLNRPELTAekfvdDPFVPGerMYRTGDLARWLPDGNIEFLGRIDHQVKIRGYRIELGEIEARLLQHPDIKEAVVIA 425
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1595048490 493 VPDPYRGETVKA-VVSLRAgavADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRREL 555
Cdd:cd17655 426 RKDEQGQNYLCAyIVSEKE---LPVAQLREFLARELPDYMIPSYFIKLDEIPLTPNGKVDRKAL 486
|
|
| PLN02654 |
PLN02654 |
acetate-CoA ligase |
48-556 |
3.08e-32 |
|
acetate-CoA ligase
Pssm-ID: 215353 [Multi-domain] Cd Length: 666 Bit Score: 131.56 E-value: 3.08e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 48 FDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVL 127
Cdd:PLN02654 117 FDASLTYSELLDRVCQLANYLKDVGVKKGDAVVIYLPMLMELPIAMLACARIGAVHSVVFAGFSAESLAQRIVDCKPKVV 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 128 I-CDAALEG-------EVVREVIASIEAEGNAAPRVFTTRARALQTRDDPRvfgtqreasgaGEGARDLLQAAQAVQPGR 199
Cdd:PLN02654 197 ItCNAVKRGpktinlkDIVDAALDESAKNGVSVGICLTYENQLAMKREDTK-----------WQEGRDVWWQDVVPNYPT 265
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 200 KPPPVVLAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQT-------YRDF--------CGLREGGPILGVAPLFHITG 264
Cdd:PLN02654 266 KCEVEWVDAEDPLFLLYTSGSTGKPKGVLHTTGGYMVYTATtfkyafdYKPTdvywctadCGWITGHSYVTYGPMLNGAT 345
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 265 LVGHIGAAwiaRAPlilthrfDPAATLDAIEEHRAEFTIGAITVFIALLHHAD--ATREKLATLTKIYSGGAPIAPSvve 342
Cdd:PLN02654 346 VLVFEGAP---NYP-------DSGRCWDIVDKYKVTIFYTAPTLVRSLMRDGDeyVTRHSRKSLRVLGSVGEPINPS--- 412
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 343 AFRAKFGHV------IHGAYGLTETNSpTHMVPLARTAPVDPHSGALamgvPVPGAEAAIVDDDGNMLaageTGEivCRG 416
Cdd:PLN02654 413 AWRWFFNVVgdsrcpISDTWWQTETGG-FMITPLPGAWPQKPGSATF----PFFGVQPVIVDEKGKEI----EGE--CSG 481
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 417 PMVVPGYWNNAAAT--ADAFR---------GGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAV 485
Cdd:PLN02654 482 YLCVKKSWPGAFRTlyGDHERyettyfkpfAGYYFSGDGCSRDKDGYYWLTGRVDDVINVSGHRIGTAEVESALVSHPQC 561
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1595048490 486 REAAVVGVPDPYRGETVKAVVSLRAGaVADAAE----LIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:PLN02654 562 AEAAVVGIEHEVKGQGIYAFVTLVEG-VPYSEElrksLILTVRNQIGAFAAPDKIHWAPGLPKTRSGKIMRRILR 635
|
|
| FATP_chFAT1_like |
cd05937 |
Uncharacterized subfamily of bifunctional fatty acid transporter/very-long-chain acyl-CoA ... |
54-556 |
9.90e-32 |
|
Uncharacterized subfamily of bifunctional fatty acid transporter/very-long-chain acyl-CoA synthetase in fungi; Fatty acid transport protein (FATP) transports long-chain or very-long-chain fatty acids across the plasma membrane. FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. FATPs are the key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis. Members of this family are fungal FATPs, including FAT1 from Cochliobolus heterostrophus.
Pssm-ID: 341260 [Multi-domain] Cd Length: 468 Bit Score: 127.93 E-value: 9.90e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 54 WQALDAWSDRIACLLLDE-GVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLICDaa 132
Cdd:cd05937 8 YSETYDLVLRYAHWLHDDlGVQAGDFVAIDLTNSPEFVFLWLGLWSIGAAPAFINYNLSGDPLIHCLKLSGSRFVIVD-- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 133 legevvreviasieaegnaaprvfttraralqtrDDprvfgtqreasgagegardllqaaqavqpgrkpppvvlaasDPA 212
Cdd:cd05937 86 ----------------------------------PD-----------------------------------------DPA 90
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 213 MLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGlvGHIGAAWI--ARAPLILTHRFDPAAT 290
Cdd:cd05937 91 ILIYTSGTTGLPKAAAISWRRTLVTSNLLSHDLNLKNGDRTYTCMPLYHGTA--AFLGACNClmSGGTLALSRKFSASQF 168
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 291 LDAIEEHRAEFT--IGAITVFiaLLHHADATREKLATLTKIYSGGapIAPSVVEAFRAKFG-HVIHGAYGLTE------- 360
Cdd:cd05937 169 WKDVRDSGATIIqyVGELCRY--LLSTPPSPYDRDHKVRVAWGNG--LRPDIWERFRERFNvPEIGEFYAATEgvfaltn 244
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 361 -------TNSPTHMVPLAR------TAPV--DPHSGALAMGvpvPGAEAAIVdddgnmLAAGETGEIVCRGPMV----VP 421
Cdd:cd05937 245 hnvgdfgAGAIGHHGLIRRwkfenqVVLVkmDPETDDPIRD---PKTGFCVR------APVGEPGEMLGRVPFKnreaFQ 315
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 422 GYWNNAAATA-----DAFRGG--WFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVP 494
Cdd:cd05937 316 GYLHNEDATEsklvrDVFRKGdiYFRTGDLLRQDADGRWYFLDRLGDTFRWKSENVSTTEVADVLGAHPDIAEANVYGVK 395
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1595048490 495 DP-YRGETVKAVVSLRAGAVA----DAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:cd05937 396 VPgHDGRAGCAAITLEESSAVptefTKSLLASLARKNLPSYAVPLFLRLTEEVATTDNHKQQKGVLR 462
|
|
| PRK12316 |
PRK12316 |
peptide synthase; Provisional |
31-555 |
4.97e-31 |
|
peptide synthase; Provisional
Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 129.31 E-value: 4.97e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 31 MFAAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMN 110
Cdd:PRK12316 3062 LFEEQVERTPDAVALAFGEQRLSYAELNRRANRLAHRLIERGVGPDVLVGVAVERSLEMVVGLLAILKAGGAYVPLDPEY 3141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 111 RARELKLLLDDSQARVLICDAALEgevvreviasieaegnaaprvfttraralqtrdDPRVFGTQReasgagegardLLQ 190
Cdd:PRK12316 3142 PEERLAYMLEDSGAQLLLSQSHLR---------------------------------LPLAQGVQV-----------LDL 3177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 191 AAQAVQPGRKPPPVVLAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPlFHITGLVGHIG 270
Cdd:PRK12316 3178 DRGDENYAEANPAIRTMPENLAYVIYTSGSTGKPKGVGIRHSALSNHLCWMQQAYGLGVGDRVLQFTT-FSFDVFVEELF 3256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 271 AAWIARAPLILTHR---FDPAATLDAIEEHRAEFTIGAITVFIALLHHADATRekLATLTKIYSGGAPIAPSVVEAFRAk 347
Cdd:PRK12316 3257 WPLMSGARVVLAGPedwRDPALLVELINSEGVDVLHAYPSMLQAFLEEEDAHR--CTSLKRIVCGGEALPADLQQQVFA- 3333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 348 fGHVIHGAYGLTETnspthMVPLARTAPVDPHSGALAMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWNNA 427
Cdd:PRK12316 3334 -GLPLYNLYGPTEA-----TITVTHWQCVEEGKDAVPIGRPIANRACYILDGSLEPVPVGALGELYLGGEGLARGYHNRP 3407
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 428 AATADAFRGGWF-------HTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVpdpyRGE 500
Cdd:PRK12316 3408 GLTAERFVPDPFvpgerlyRTGDLARYRADGVIEYIGRVDHQVKIRGFRIELGEIEARLLEHPWVREAVVLAV----DGR 3483
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*
gi 1595048490 501 TVKAVVSLRAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRREL 555
Cdd:PRK12316 3484 QLVAYVVPEDEAGDLREALKAHLKASLPEYMVPAHLLFLERMPLTPNGKLDRKAL 3538
|
|
| LC_FACS_like |
cd17640 |
Long-chain fatty acid CoA synthetase; This family includes long-chain fatty acid (C12-C20) CoA ... |
63-492 |
1.72e-30 |
|
Long-chain fatty acid CoA synthetase; This family includes long-chain fatty acid (C12-C20) CoA synthetases, including an Arabidopsis gene At4g14070 that plays a role in activation and elongation of exogenous fatty acids. FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Eukaryotes generally have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.
Pssm-ID: 341295 [Multi-domain] Cd Length: 468 Bit Score: 124.39 E-value: 1.72e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 63 RIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLICDaalegevvrevi 142
Cdd:cd17640 17 DFAAGLRSLGVKAGEKVALFADNSPRWLIADQGIMALGAVDVVRGSDSSVEELLYILNHSESVALVVE------------ 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 143 asieaegnaaprvfttraralqtrDDPrvfgtqreasgagegardllqaaqavqpgrkpppvvlaaSDPAMLVYTSGTSG 222
Cdd:cd17640 85 ------------------------NDS---------------------------------------DDLATIIYTSGTTG 101
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 223 RPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLVghigAAWIARAPLILTHRFDPAATLDAIEEHRAEFT 302
Cdd:cd17640 102 NPKGVMLTHANLLHQIRSLSDIVPPQPGDRFLSILPIWHSYERS----AEYFIFACGCSQAYTSIRTLKDDLKRVKPHYI 177
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 303 IGAITVFIAL-------LHHADATREKLA-TLTKI------YSGGAPIAPSVVEAFRAKFGHVIHGaYGLTETnSPThmv 368
Cdd:cd17640 178 VSVPRLWESLysgiqkqVSKSSPIKQFLFlFFLSGgifkfgISGGGALPPHVDTFFEAIGIEVLNG-YGLTET-SPV--- 252
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 369 pLARTAPVDPHSGALamGVPVPGAEAAIVDDDGN-MLAAGETGEIVCRGPMVVPGYWNNAAATADAFRG-GWFHTGDVGF 446
Cdd:cd17640 253 -VSARRLKCNVRGSV--GRPLPGTEIKIVDPEGNvVLPPGEKGIVWVRGPQVMKGYYKNPEATSKVLDSdGWFNTGDLGW 329
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 1595048490 447 MDEAGWFYLVDRKKDMIN-AAGYKVWPREVEDVLYGHPAVREAAVVG 492
Cdd:cd17640 330 LTCGGELVLTGRAKDTIVlSNGENVEPQPIEEALMRSPFIEQIMVVG 376
|
|
| PRK12467 |
PRK12467 |
peptide synthase; Provisional |
31-555 |
4.72e-30 |
|
peptide synthase; Provisional
Pssm-ID: 237108 [Multi-domain] Cd Length: 3956 Bit Score: 126.04 E-value: 4.72e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 31 MFAAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMN 110
Cdd:PRK12467 517 LIEAQARQHPERPALVFGEQVLSYAELNRQANRLAHVLIAAGVGPDVLVGIAVERSIEMVVGLLAVLKAGGAYVPLDPEY 596
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 111 RARELKLLLDDSQARVLICDAALegevvreviasieaegnaaprvfttrARALQTRDDPRVFGTQREAsgagegarDLLQ 190
Cdd:PRK12467 597 PQDRLAYMLDDSGVRLLLTQSHL--------------------------LAQLPVPAGLRSLCLDEPA--------DLLC 642
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 191 AAQAVQPgrkppPVVLAASDPAMLVYTSGTSGRPKGAICTHGNFAfnsqtyRDFCGLREGGPILGVAPLFHITGLVGHIG 270
Cdd:PRK12467 643 GYSGHNP-----EVALDPDNLAYVIYTSGSTGQPKGVAISHGALA------NYVCVIAERLQLAADDSMLMVSTFAFDLG 711
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 271 -----AAWIARAPLILTHR---FDPAATLDAIEEHRAEFTIGAITVFIALLHhaDATREKLATLTKIYSGGAPIAPS-VV 341
Cdd:PRK12467 712 vtelfGALASGATLHLLPPdcaRDAEAFAALMADQGVTVLKIVPSHLQALLQ--ASRVALPRPQRALVCGGEALQVDlLA 789
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 342 EAFRAKFGHVIHGAYGLTETNSPTHMVPLaRTAPVDphSGALAMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVP 421
Cdd:PRK12467 790 RVRALGPGARLINHYGPTETTVGVSTYEL-SDEERD--FGNVPIGQPLANLGLYILDHYLNPVPVGVVGELYIGGAGLAR 866
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 422 GYWNNAAATADAF-------RGG-WFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGV 493
Cdd:PRK12467 867 GYHRRPALTAERFvpdpfgaDGGrLYRTGDLARYRADGVIEYLGRMDHQVKIRGFRIELGEIEARLLAQPGVREAVVLAQ 946
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1595048490 494 PDPYRGETVKAVVSlraGAVADAA-------ELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRREL 555
Cdd:PRK12467 947 PGDAGLQLVAYLVP---AAVADGAehqatrdELKAQLRQVLPDYMVPAHLLLLDSLPLTPNGKLDRKAL 1012
|
|
| PRK05857 |
PRK05857 |
fatty acid--CoA ligase; |
37-555 |
6.03e-30 |
|
fatty acid--CoA ligase;
Pssm-ID: 180293 [Multi-domain] Cd Length: 540 Bit Score: 123.58 E-value: 6.03e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 37 ERAPHESALLYFDG--RLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVN----PMN 110
Cdd:PRK05857 25 RQQPEAIALRRCDGtsALRYRELVAEVGGLAADLRAQSVSRGSRVLVISDNGPETYLSVLACAKLGAIAVMADgnlpIAA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 111 RARELKLLldDSQARVLICDAALEGEVVREVIASIeaegnAAPRVFTTraralqtrddprvfgtqreaSGAGEGARDLLQ 190
Cdd:PRK05857 105 IERFCQIT--DPAAALVAPGSKMASSAVPEALHSI-----PVIAVDIA--------------------AVTRESEHSLDA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 191 AAQAVQPGrkpppvvLAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFcGLREGGPILG---VAPLfhitgLVG 267
Cdd:PRK05857 158 ASLAGNAD-------QGSEDPLAMIFTSGTTGEPKAVLLANRTFFAVPDILQKE-GLNWVTWVVGettYSPL-----PAT 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 268 HIGAAW-----IARAPLILTHRFDPAATLDAIEEHRAEFTIGAITVFIALLHHADATREKLATLTKI-YSGGAPIAPSV- 340
Cdd:PRK05857 225 HIGGLWwiltcLMHGGLCVTGGENTTSLLEILTTNAVATTCLVPTLLSKLVSELKSANATVPSLRLVgYGGSRAIAADVr 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 341 -VEAFRAKFGHVihgaYGLTETNSPTHMVPLARTAPVDPHSGALamGVPVPGAEAAIVDDDG---NMLAAGET---GEIV 413
Cdd:PRK05857 305 fIEATGVRTAQV----YGLSETGCTALCLPTDDGSIVKIEAGAV--GRPYPGVDVYLAATDGigpTAPGAGPSasfGTLW 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 414 CRGPMVVPGYWNNAAATADAFRGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGV 493
Cdd:PRK05857 379 IKSPANMLGYWNNPERTAEVLIDGWVNTGDLLERREDGFFYIKGRSSEMIICGGVNIAPDEVDRIAEGVSGVREAACYEI 458
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1595048490 494 PDPYRGETVK-AVVslrAGAVADAAELIAFcKARMAA-YK-------YPRIVEFRDELPKTATGKILRREL 555
Cdd:PRK05857 459 PDEEFGALVGlAVV---ASAELDESAARAL-KHTIAArFRresepmaRPSTIVIVTDIPRTQSGKVMRASL 525
|
|
| PRK08308 |
PRK08308 |
acyl-CoA synthetase; Validated |
207-555 |
6.97e-30 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236231 [Multi-domain] Cd Length: 414 Bit Score: 121.68 E-value: 6.97e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 207 AASDPAMLVYTSGTSGRPK------GAICTHGNfAFNSQtyrdFCGLREGGPILgVAPLFHITGLVGHIGAAwIAR--AP 278
Cdd:PRK08308 99 LAEEPSLLQYSSGTTGEPKlirrswTEIDREIE-AYNEA----LNCEQDETPIV-ACPVTHSYGLICGVLAA-LTRgsKP 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 279 LILTHRfDPAATLDAIEEHRAEFTIGAItvfiALLHH-ADATREKlATLTKIYSGGAPIAPSVVEAFRAKFGHVIHgAYG 357
Cdd:PRK08308 172 VIITNK-NPKFALNILRNTPQHILYAVP----LMLHIlGRLLPGT-FQFHAVMTSGTPLPEAWFYKLRERTTYMMQ-QYG 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 358 LTEtnspthmvplARTAPVDPH-SGALAMGVPVPGAEAAIVDDDGNmlaageTGEIVCrgpmvvpgyWNNAAAtadafrg 436
Cdd:PRK08308 245 CSE----------AGCVSICPDmKSHLDLGNPLPHVSVSAGSDENA------PEEIVV---------KMGDKE------- 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 437 gwFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSlrAGAVADA 516
Cdd:PRK08308 293 --IFTKDLGYKSERGTLHFMGRMDDVINVSGLNVYPIEVEDVMLRLPGVQEAVVYRGKDPVAGERVKAKVI--SHEEIDP 368
|
330 340 350
....*....|....*....|....*....|....*....
gi 1595048490 517 AELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRREL 555
Cdd:PRK08308 369 VQLREWCIQHLAPYQVPHEIESVTEIPKNANGKVSRKLL 407
|
|
| PRK05691 |
PRK05691 |
peptide synthase; Validated |
30-555 |
8.37e-30 |
|
peptide synthase; Validated
Pssm-ID: 235564 [Multi-domain] Cd Length: 4334 Bit Score: 125.28 E-value: 8.37e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 30 DMFAAALERAPHESALLyFDGR-LDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNP 108
Cdd:PRK05691 2192 GLFAAQAARTPQAPALT-FAGQtLSYAELDARANRLARALRERGVGPQVRVGLALERSLEMVVGLLAILKAGGAYVPLDP 2270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 109 MNRARELKLLLDDSQARVLICDAALegevvreviasIEAEGNAAPRVfttrAR-ALQtrDDprvfgtqreasgagegard 187
Cdd:PRK05691 2271 EYPLERLHYMIEDSGIGLLLSDRAL-----------FEALGELPAGV----ARwCLE--DD------------------- 2314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 188 llQAAQAVQPGrKPPPVVLAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILG------------ 255
Cdd:PRK05691 2315 --AAALAAYSD-APLPFLSLPQHQAYLIYTSGSTGKPKGVVVSHGEIAMHCQAVIERFGMRADDCELHfysinfdaaser 2391
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 256 -VAPLfhitgLVGhigaawiARAPLILTHRFDPAATLDAIEEHRAEFtIGAITVFIALLHHADATREKLATLTKIYSGGA 334
Cdd:PRK05691 2392 lLVPL-----LCG-------ARVVLRAQGQWGAEEICQLIREQQVSI-LGFTPSYGSQLAQWLAGQGEQLPVRMCITGGE 2458
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 335 PIAPSVVEAFRAKFG-HVIHGAYGLTETNspthMVPLARTAP--VDPHSGALAMGVPVPGAEAAIVDDDGNMLAAGETGE 411
Cdd:PRK05691 2459 ALTGEHLQRIRQAFApQLFFNAYGPTETV----VMPLACLAPeqLEEGAASVPIGRVVGARVAYILDADLALVPQGATGE 2534
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 412 IVCRGPMVVPGYWNNAAATADAF--------RGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHP 483
Cdd:PRK05691 2535 LYVGGAGLAQGYHDRPGLTAERFvadpfaadGGRLYRTGDLVRLRADGLVEYVGRIDHQVKIRGFRIELGEIESRLLEHP 2614
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1595048490 484 AVREAAVVGVPDPYRGETVKAVVSLRAGAVADA-----AELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRREL 555
Cdd:PRK05691 2615 AVREAVVLALDTPSGKQLAGYLVSAVAGQDDEAqaalrEALKAHLKQQLPDYMVPAHLILLDSLPLTANGKLDRRAL 2691
|
|
| PRK05691 |
PRK05691 |
peptide synthase; Validated |
36-556 |
1.90e-29 |
|
peptide synthase; Validated
Pssm-ID: 235564 [Multi-domain] Cd Length: 4334 Bit Score: 124.12 E-value: 1.90e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 36 LERAPHESALL-YFDgrLDWQAldawsdRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARE 114
Cdd:PRK05691 31 LADDPGEGVVLsYRD--LDLRA------RTIAAALQARASFGDRAVLLFPSGPDYVAAFFGCLYAGVIAVPAYPPESARR 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 115 -----LKLLLDDSQARVLICDAALegevvREVIASIEA-EGNAAPRVFTTraralqtrddprvfgtqreasgagegarDL 188
Cdd:PRK05691 103 hhqerLLSIIADAEPRLLLTVADL-----RDSLLQMEElAAANAPELLCV----------------------------DT 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 189 LQAAQAvQPGRKPppvVLAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLrEGGP---ILGVAPLFHITGL 265
Cdd:PRK05691 150 LDPALA-EAWQEP---ALQPDDIAFLQYTSGSTALPKGVQVSHGNLVANEQLIRHGFGI-DLNPddvIVSWLPLYHDMGL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 266 VGHI------GAAWIARAPLILTHRfdPAATLDAIEEHRAefTIGAITVFIALLHHADATREKLATLT-----KIYSGGA 334
Cdd:PRK05691 225 IGGLlqpifsGVPCVLMSPAYFLER--PLRWLEAISEYGG--TISGGPDFAYRLCSERVSESALERLDlsrwrVAYSGSE 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 335 PIAPSVVEAFRAKFG------HVIHGAYGLTETN------SPTHMVP--------LARTApVDPHSGALAM--GVPVPGA 392
Cdd:PRK05691 301 PIRQDSLERFAEKFAacgfdpDSFFASYGLAEATlfvsggRRGQGIPaleldaeaLARNR-AEPGTGSVLMscGRSQPGH 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 393 EAAIVD-DDGNMLAAGETGEIVCRGPMVVPGYWNNAAATADAF--RGG--WFHTGDVGFMDEaGWFYLVDRKKDMINAAG 467
Cdd:PRK05691 380 AVLIVDpQSLEVLGDNRVGEIWASGPSIAHGYWRNPEASAKTFveHDGrtWLRTGDLGFLRD-GELFVTGRLKDMLIVRG 458
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 468 YKVWPREVEDVLYGH-PAVREAAVVGVPDPYRGET---VKAVVSLRAGAVADAAELIAFCKARMA-AYK-YPRIVEFRD- 540
Cdd:PRK05691 459 HNLYPQDIEKTVEREvEVVRKGRVAAFAVNHQGEEgigIAAEISRSVQKILPPQALIKSIRQAVAeACQeAPSVVLLLNp 538
|
570
....*....|....*..
gi 1595048490 541 -ELPKTATGKILRRELR 556
Cdd:PRK05691 539 gALPKTSSGKLQRSACR 555
|
|
| A_NRPS_PpsD_like |
cd17650 |
similar to adenylation domain of plipastatin synthase (PpsD); This family of the adenylation ... |
40-555 |
8.76e-29 |
|
similar to adenylation domain of plipastatin synthase (PpsD); This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes bacitracin synthetase 1 (BacA) in Bacillus licheniformis, tyrocidine synthetase in Brevibacillus brevis, plipastatin synthase (PpsD, an important antifungal protein) in Bacillus subtilis and mannopeptimycin peptide synthetase (MppB) in Streptomyces hygroscopicus. Plipastatin has strong fungitoxic activity and is involved in inhibition of phospholipase A2 and biofilm formation. Bacitracin, a mixture of related cyclic peptides, is used as a polypeptide antibiotic while function of tyrocidine is thought to be regulation of sporulation. MppB is involved in biosynthetic pathway of mannopeptimycin, a novel class of mannosylated lipoglycopeptides. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341305 [Multi-domain] Cd Length: 447 Bit Score: 119.11 E-value: 8.76e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 40 PHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLL 119
Cdd:cd17650 1 PDAIAVSDATRQLTYRELNERANQLARTLRGLGVAPGSVVGVCADRSLDAIVGLLAVLKAGGAYVPIDPDYPAERLQYML 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 120 DDSQARVLIcdaalegevvreviasieaegnaaprvfttraralqtrddprvfgtqreasgagegardllqaaqaVQPGr 199
Cdd:cd17650 81 EDSGAKLLL------------------------------------------------------------------TQPE- 93
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 200 kpppvvlaasDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLVGHIGAAWIARAPL 279
Cdd:cd17650 94 ----------DLAYVIYTSGTTGKPKGVMVEHRNVAHAAHAWRREYELDSFPVRLLQMASFSFDVFAGDFARSLLNGGTL 163
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 280 ILTH---RFDPAATLDAIEEHRAEFTIGAITVFIALLHHADATREKLATLTKIYSG--GAPIAPSVVEAFRAKFGHVIHG 354
Cdd:cd17650 164 VICPdevKLDPAALYDLILKSRITLMESTPALIRPVMAYVYRNGLDLSAMRLLIVGsdGCKAQDFKTLAARFGQGMRIIN 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 355 AYGLTETNSPTHMVPLARTApvDPHSGALAMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWNNAAATADAF 434
Cdd:cd17650 244 SYGVTEATIDSTYYEEGRDP--LGDSANVPIGRPLPNTAMYVLDERLQPQPVGVAGELYIGGAGVARGYLNRPELTAERF 321
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 435 R-------GGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDpyRGETVKAVVS 507
Cdd:cd17650 322 VenpfapgERMYRTGDLARWRADGNVELLGRVDHQVKIRGFRIELGEIESQLARHPAIDEAVVAVRED--KGGEARLCAY 399
|
490 500 510 520
....*....|....*....|....*....|....*....|....*...
gi 1595048490 508 LRAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRREL 555
Cdd:cd17650 400 VVAAATLNTAELRAFLAKELPSYMIPSYYVQLDALPLTPNGKVDRRAL 447
|
|
| PRK12467 |
PRK12467 |
peptide synthase; Provisional |
21-555 |
2.26e-28 |
|
peptide synthase; Provisional
Pssm-ID: 237108 [Multi-domain] Cd Length: 3956 Bit Score: 121.04 E-value: 2.26e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 21 PQQEYTNGL---DMFAAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIW 97
Cdd:PRK12467 1566 THTGYPLARlvhQLIEDQAAATPEAVALVFGEQELTYGELNRRANRLAHRLIALGVGPEVLVGIAVERSLEMVVGLLAIL 1645
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 98 KAGAVMVPVNPMNRARELKLLLDDSQARVLICDAALegevvreviasieaegnaAPRVfttraralqtrddprvfgtqre 177
Cdd:PRK12467 1646 KAGGAYVPLDPEYPRERLAYMIEDSGIELLLTQSHL------------------QARL---------------------- 1685
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 178 asGAGEGARDL-LQAAQAVQPGRKP--PPVVLAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPIL 254
Cdd:PRK12467 1686 --PLPDGLRSLvLDQEDDWLEGYSDsnPAVNLAPQNLAYVIYTSGSTGRPKGAGNRHGALVNRLCATQEAYQLSAADVVL 1763
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 255 GVAPL---FHITGLVGHI--GAAWIARAPLIltHRfDPAATLDAIEEHRAEFTIGAITVFIALLHHADATREKLAtLTKI 329
Cdd:PRK12467 1764 QFTSFafdVSVWELFWPLinGARLVIAPPGA--HR-DPEQLIQLIERQQVTTLHFVPSMLQQLLQMDEQVEHPLS-LRRV 1839
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 330 YSGGAPIAPSVVEAFRAKFGHV-IHGAYGLTETN-SPTHmvplaRTA-PVDPHSGALA-MGVPVPGAEAAIVDDDGNMLA 405
Cdd:PRK12467 1840 VCGGEALEVEALRPWLERLPDTgLFNLYGPTETAvDVTH-----WTCrRKDLEGRDSVpIGQPIANLSTYILDASLNPVP 1914
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 406 AGETGEIVCRGPMVVPGYWNNAAATADAF------RGG--WFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVED 477
Cdd:PRK12467 1915 IGVAGELYLGGVGLARGYLNRPALTAERFvadpfgTVGsrLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIEA 1994
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 478 VLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVADA-------AELIAFCKARMAAYKYPRIVEFRDELPKTATGKI 550
Cdd:PRK12467 1995 RLREQGGVREAVVIAQDGANGKQLVAYVVPTDPGLVDDDeaqvalrAILKNHLKASLPEYMVPAHLVFLARMPLTPNGKL 2074
|
....*
gi 1595048490 551 LRREL 555
Cdd:PRK12467 2075 DRKAL 2079
|
|
| PRK06060 |
PRK06060 |
p-hydroxybenzoic acid--AMP ligase FadD22; |
63-556 |
3.18e-28 |
|
p-hydroxybenzoic acid--AMP ligase FadD22;
Pssm-ID: 180374 [Multi-domain] Cd Length: 705 Bit Score: 119.37 E-value: 3.18e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 63 RIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLICDAALegevvrevi 142
Cdd:PRK06060 42 RLGEVLRNRGLSSGDRVLLCLPDSPDLVQLLLACLARGVMAFLANPELHRDDHALAARNTEPALVVTSDAL--------- 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 143 asieaegnaaprvfttraralqtRDdprvfgtqREASGAGEGARDLLQAAQAVQPGRKPPpvvLAASDPAMLVYTSGTSG 222
Cdd:PRK06060 113 -----------------------RD--------RFQPSRVAEAAELMSEAARVAPGGYEP---MGGDALAYATYTSGTTG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 223 RPKGAICTHGN-FAFNSQTYRDFCGLREGGPILGVAPLFHITGLVGHI-------GAAWIARAPL------ILTHRFDPA 288
Cdd:PRK06060 159 PPKAAIHRHADpLTFVDAMCRKALRLTPEDTGLCSARMYFAYGLGNSVwfplatgGSAVINSAPVtpeaaaILSARFGPS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 289 aTLDAIEEHRAEfTIGAITvfiallhhADATReklaTLTKIYSGGAPIAPSVVEAFRAKFGHV-IHGAYGLTETNSPthm 367
Cdd:PRK06060 239 -VLYGVPNFFAR-VIDSCS--------PDSFR----SLRCVVSAGEALELGLAERLMEFFGGIpILDGIGSTEVGQT--- 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 368 vpLARTAPVDPHSGALamGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWNNAAATADafRGGWFHTGDVGFM 447
Cdd:PRK06060 302 --FVSNRVDEWRLGTL--GRVLPPYEIRVVAPDGTTAGPGVEGDLWVRGPAIAKGYWNRPDSPVA--NEGWLDTRDRVCI 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 448 DEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVADAAELIAFCK--- 524
Cdd:PRK06060 376 DSDGWVTYRCRADDTEVIGGVNVDPREVERLIIEDEAVAEAAVVAVRESTGASTLQAFLVATSGATIDGSVMRDLHRgll 455
|
490 500 510
....*....|....*....|....*....|..
gi 1595048490 525 ARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:PRK06060 456 NRLSAFKVPHRFAVVDRLPRTPNGKLVRGALR 487
|
|
| PRK04813 |
PRK04813 |
D-alanine--poly(phosphoribitol) ligase subunit DltA; |
44-555 |
4.17e-28 |
|
D-alanine--poly(phosphoribitol) ligase subunit DltA;
Pssm-ID: 235313 [Multi-domain] Cd Length: 503 Bit Score: 117.69 E-value: 4.17e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 44 ALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVN---PMNRareLKLLLD 120
Cdd:PRK04813 20 AYDYLGEKLTYGQLKEDSDALAAFIDSLKLPDKSPIIVFGHMSPEMLATFLGAVKAGHAYIPVDvssPAER---IEMIIE 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 121 DSQARVLIC--DAALEGEVVREVIASIEAEGNAAPRVFttraralqtrddprvfgtqreasgagegardllQAAQAVQpg 198
Cdd:PRK04813 97 VAKPSLIIAteELPLEILGIPVITLDELKDIFATGNPY---------------------------------DFDHAVK-- 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 199 rkpppvvlaASDPAMLVYTSGTSGRPKGAICTHGNF-AFNSQTYRDFcGLREGGPILGVAPL-FHITGLvghigaAWiar 276
Cdd:PRK04813 142 ---------GDDNYYIIFTSGTTGKPKGVQISHDNLvSFTNWMLEDF-ALPEGPQFLNQAPYsFDLSVM------DL--- 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 277 APLILThrfdpAATLDAIE-----------EHRAEFTIGAIT-----VFIALLHhADATREKLATLTKIYSGGAPIAPSV 340
Cdd:PRK04813 203 YPTLAS-----GGTLVALPkdmtanfkqlfETLPQLPINVWVstpsfADMCLLD-PSFNEEHLPNLTHFLFCGEELPHKT 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 341 VEAFRAKFGH-VIHGAYGLTETnspTHMVP-LARTAPVDPHSGALAMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPM 418
Cdd:PRK04813 277 AKKLLERFPSaTIYNTYGPTEA---TVAVTsIEITDEMLDQYKRLPIGYAKPDSPLLIIDEEGTKLPDGEQGEIVISGPS 353
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 419 VVPGYWNNAAATADAF---RGGW-FHTGDVGFMDEAGWFYLvDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVgvp 494
Cdd:PRK04813 354 VSKGYLNNPEKTAEAFftfDGQPaYHTGDAGYLEDGLLFYQ-GRIDFQIKLNGYRIELEEIEQNLRQSSYVESAVVV--- 429
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1595048490 495 dPY-RGETVK---AVVSLRAGAVADAAELIAFCKA----RMAAYKYPRIVEFRDELPKTATGKILRREL 555
Cdd:PRK04813 430 -PYnKDHKVQyliAYVVPKEEDFEREFELTKAIKKelkeRLMEYMIPRKFIYRDSLPLTPNGKIDRKAL 497
|
|
| LC_FACS_euk1 |
cd17639 |
Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins; The ... |
208-495 |
2.24e-27 |
|
Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins; The members of this family are eukaryotic fatty acid CoA synthetases (EC 6.2.1.3) that activate fatty acids with chain lengths of 12 to 20 and includes fungal proteins. They act on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Organisms tend to have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells. In Schizosaccharomyces pombe, lcf1 gene encodes a new fatty acyl-CoA synthetase that preferentially recognizes myristic acid as a substrate.
Pssm-ID: 341294 [Multi-domain] Cd Length: 507 Bit Score: 115.78 E-value: 2.24e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 208 ASDPAMLVYTSGTSGRPKGAICTHGNF--AFNSQTYRDFCGLREGGPILGVAPLFHITGLV---------GHIGAAwiar 276
Cdd:cd17639 87 PDDLACIMYTSGSTGNPKGVMLTHGNLvaGIAGLGDRVPELLGPDDRYLAYLPLAHIFELAaenvclyrgGTIGYG---- 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 277 APLILT-----------HRFDP------AATLD----AIEEHRAEftIGAI--TVFiallHHADATREKL---------- 323
Cdd:cd17639 163 SPRTLTdkskrgckgdlTEFKPtlmvgvPAIWDtirkGVLAKLNP--MGGLkrTLF----WTAYQSKLKAlkegpgtpll 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 324 ----------AT---LTKIYSGGAPIAPSVVEAFRAKFGHVIHGaYGLTETNSPThmvplARTAPVDPHSGALamGVPVP 390
Cdd:cd17639 237 delvfkkvraALggrLRYMLSGGAPLSADTQEFLNIVLCPVIQG-YGLTETCAGG-----TVQDPGDLETGRV--GPPLP 308
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 391 GAEAAIVD-DDGNMLA-AGET-GEIVCRGPMVVPGYWNNAAATADAFRG-GWFHTGDVGFMDEAGWFYLVDRKKDMI-NA 465
Cdd:cd17639 309 CCEIKLVDwEEGGYSTdKPPPrGEILIRGPNVFKGYYKNPEKTKEAFDGdGWFHTGDIGEFHPDGTLKIIDRKKDLVkLQ 388
|
330 340 350
....*....|....*....|....*....|
gi 1595048490 466 AGYKVWPREVEDVLYGHPAVREAAVVGVPD 495
Cdd:cd17639 389 NGEYIALEKLESIYRSNPLVNNICVYADPD 418
|
|
| A_NRPS_LgrA-like |
cd17645 |
adenylation (A) domain of linear gramicidin synthetase (LgrA) and similar proteins; This ... |
31-555 |
3.68e-27 |
|
adenylation (A) domain of linear gramicidin synthetase (LgrA) and similar proteins; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes linear gramicidin synthetase (LgrA) in Brevibacillus brevis. LgrA has a formylation domain fused to the N-terminal end that formylates its substrate for linear gramicidin synthesis to proceed. This formyl group is essential for the clinically important antibacterial activity of gramicidin by enabling head-to-head gramicidin dimers to make a beta-helical pore in gram-positive bacterial membranes, allowing free passage of monovalent cations, destroying the ion gradient and killing bacteria. This family also includes bacitracin synthetase 1 (known as ATP-dependent cysteine adenylase or BA1); it activates cysteine, incorporates two D-amino acids, releases and cyclizes the mature bacitracin, an antibiotic that is a mixture of related cyclic peptides that disrupt gram positive bacteria by interfering with cell wall and peptidoglycan synthesis. Also included is surfactin synthetase which activates and polymerizes the amino acids Leu, Glu, Asp, and Val to form the antibiotic surfactin.
Pssm-ID: 341300 [Multi-domain] Cd Length: 440 Bit Score: 114.19 E-value: 3.68e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 31 MFAAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMN 110
Cdd:cd17645 3 LFEEQVERTPDHVAVVDRGQSLTYKQLNEKANQLARHLRGKGVKPDDQVGIMLDKSLDMIAAILGVLKAGGAYVPIDPDY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 111 RARELKLLLDDSQARVLICDAalegevvreviasieaegnaaprvfttraralqtrddprvfgtqreasgagegardllq 190
Cdd:cd17645 83 PGERIAYMLADSSAKILLTNP----------------------------------------------------------- 103
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 191 aaqavqpgrkpppvvlaaSDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPlFHITGLVGHIG 270
Cdd:cd17645 104 ------------------DDLAYVIYTSGSTGLPKGVMIEHHNLVNLCEWHRPYFGVTPADKSLVYAS-FSFDASAWEIF 164
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 271 AAWIARAPLILTH---RFDPAATLDAIEEHRAEFTI---GAITVFIALLHHadatreklaTLTKIYSGGapiapSVVEAF 344
Cdd:cd17645 165 PHLTAGAALHVVPserRLDLDALNDYFNQEGITISFlptGAAEQFMQLDNQ---------SLRVLLTGG-----DKLKKI 230
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 345 RAKfGHVIHGAYGltetnsPTHMVPLARTAPVDPHSGALAMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYW 424
Cdd:cd17645 231 ERK-GYKLVNNYG------PTENTVVATSFEIDKPYANIPIGKPIDNTRVYILDEALQLQPIGVAGELCIAGEGLARGYL 303
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 425 NNAAATADAFRGGWF-------HTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPY 497
Cdd:cd17645 304 NRPELTAEKFIVHPFvpgermyRTGDLAKFLPDGNIEFLGRLDQQVKIRGYRIEPGEIEPFLMNHPLIELAAVLAKEDAD 383
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*...
gi 1595048490 498 RGETVKAVVSlrAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRREL 555
Cdd:cd17645 384 GRKYLVAYVT--APEEIPHEELREWLKNDLPDYMIPTYFVHLKALPLTANGKVDRKAL 439
|
|
| AMP-binding_C |
pfam13193 |
AMP-binding enzyme C-terminal domain; This is a small domain that is found C terminal to ... |
474-549 |
4.06e-27 |
|
AMP-binding enzyme C-terminal domain; This is a small domain that is found C terminal to pfam00501. It has a central beta sheet core that is flanked by alpha helices.
Pssm-ID: 463804 [Multi-domain] Cd Length: 76 Bit Score: 104.16 E-value: 4.06e-27
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1595048490 474 EVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGK 549
Cdd:pfam13193 1 EVESALVSHPAVAEAAVVGVPDELKGEAPVAFVVLKPGVELLEEELVAHVREELGPYAVPKEVVFVDELPKTRSGK 76
|
|
| A_NRPS_MycA_like |
cd05908 |
The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin ... |
212-556 |
5.96e-27 |
|
The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as (amino)-acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. This family includes NRPS similar to mycosubtilin synthase subunit A (MycA). Mycosubtilin, which is characterized by a beta-amino fatty acid moiety linked to the circular heptapeptide Asn-Tyr-Asn-Gln-Pro-Ser-Asn, belongs to the iturin family of lipopeptide antibiotics. The mycosubtilin synthase subunit A (MycA) combines functional domains derived from peptide synthetases, amino transferases, and fatty acid synthases. Nonribosomal peptide synthetases are large multifunction enzymes that synthesize many therapeutically useful peptides. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and, in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341234 [Multi-domain] Cd Length: 499 Bit Score: 114.12 E-value: 5.96e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 212 AMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLV-GHIGAAwIARAP--LILTHRF--D 286
Cdd:cd05908 109 AFIQFSSGSTGDPKGVMLTHENLVHNMFAILNSTEWKTKDRILSWMPLTHDMGLIaFHLAPL-IAGMNqyLMPTRLFirR 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 287 PAATLDAIEEHRAEFTIG---AITVFIALLHHADATREKLATLTKIYSGGAPIAPSVVEAFR---AKFG---HVIHGAYG 357
Cdd:cd05908 188 PILWLKKASEHKATIVSSpnfGYKYFLKTLKPEKANDWDLSSIRMILNGAEPIDYELCHEFLdhmSKYGlkrNAILPVYG 267
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 358 LTET---------NSP-----------THMVPLARTAPVDPHSGA-LAMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRG 416
Cdd:cd05908 268 LAEAsvgaslpkaQSPfktitlgrrhvTHGEPEPEVDKKDSECLTfVEVGKPIDETDIRICDEDNKILPDGYIGHIQIRG 347
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 417 PMVVPGYWNNAAATADAFRG-GWFHTGDVGFMDEaGWFYLVDRKKDMINAAGYKVWPR-------EVEDVLYGhpavrEA 488
Cdd:cd05908 348 KNVTPGYYNNPEATAKVFTDdGWLKTGDLGFIRN-GRLVITGREKDIIFVNGQNVYPHdieriaeELEGVELG-----RV 421
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 489 AVVGVPDPYRGETVKAVVSLRAGAVADAAELIAFCKARMAAYKYPRIVEFR--DELPKTATGKILRRELR 556
Cdd:cd05908 422 VACGVNNSNTRNEEIFCFIEHRKSEDDFYPLGKKIKKHLNKRGGWQINEVLpiRRIPKTTSGKVKRYELA 491
|
|
| A_NRPS_ProA |
cd17656 |
gramicidin S synthase 2, also known as ATP-dependent proline adenylase; This family of the ... |
40-555 |
2.26e-26 |
|
gramicidin S synthase 2, also known as ATP-dependent proline adenylase; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) contains gramicidin S synthase 2 (also known as ATP-dependent proline adenylase or proline activase or ProA). ProA is a multifunctional enzyme involved in synthesis of the cyclic peptide antibiotic gramicidin S and able to activate and polymerize the amino acids proline, valine, ornithine and leucine. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341311 [Multi-domain] Cd Length: 479 Bit Score: 112.18 E-value: 2.26e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 40 PHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLL 119
Cdd:cd17656 2 PDAVAVVFENQKLTYRELNERSNQLARFLREKGVKKDSIVAIMMERSAEMIVGILGILKAGGAFVPIDPEYPEERRIYIM 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 120 DDSQARVLICDAALegevvreviasieaegnAAPRVFTTRARALqtrDDPRVfgTQREASGAGegardllqaaqavqpgr 199
Cdd:cd17656 82 LDSGVRVVLTQRHL-----------------KSKLSFNKSTILL---EDPSI--SQEDTSNID----------------- 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 200 kpppVVLAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVA-PLFHITglVGHIGAAWIARAP 278
Cdd:cd17656 123 ----YINNSDDLLYIIYTSGTTGKPKGVQLEHKNMVNLLHFEREKTNINFSDKVLQFAtCSFDVC--YQEIFSTLLSGGT 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 279 LILTH---RFDPAATLDAIEEHRAEfTIGAITVFIALLHHADATREKLATLTK-IYSGGAP--IAPSVVEAFRAKFGHvI 352
Cdd:cd17656 197 LYIIReetKRDVEQLFDLVKRHNIE-VVFLPVAFLKFIFSEREFINRFPTCVKhIITAGEQlvITNEFKEMLHEHNVH-L 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 353 HGAYGLTETnsptHMVPLARTAPVDPHSGALAMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVPGYWNNAAATAD 432
Cdd:cd17656 275 HNHYGPSET----HVVTTYTINPEAEIPELPPIGKPISNTWIYILDQEQQLQPQGIVGELYISGASVARGYLNRQELTAE 350
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 433 AFRGGWF-------HTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKA- 504
Cdd:cd17656 351 KFFPDPFdpnermyRTGDLARYLPDGNIEFLGRADHQVKIRGYRIELGEIEAQLLNHPGVSEAVVLDKADDKGEKYLCAy 430
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 1595048490 505 VVSLRAGAVADAAELIAfckARMAAYKYPRIVEFRDELPKTATGKILRREL 555
Cdd:cd17656 431 FVMEQELNISQLREYLA---KQLPEYMIPSFFVPLDQLPLTPNGKVDRKAL 478
|
|
| LC-FACS_euk |
cd05927 |
Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS); The members of this family are ... |
200-556 |
3.90e-26 |
|
Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS); The members of this family are eukaryotic fatty acid CoA synthetases that activate fatty acids with chain lengths of 12 to 20. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Organisms tend to have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells.
Pssm-ID: 341250 [Multi-domain] Cd Length: 545 Bit Score: 112.31 E-value: 3.90e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 200 KPPPVVLAASDPAMLVYTSGTSGRPKGAICTHGNFAFNS----QTYRDFCGLREGGPILGVAPLFHI-----TGLVGHIG 270
Cdd:cd05927 105 KVPPPPPKPEDLATICYTSGTTGNPKGVMLTHGNIVSNVagvfKILEILNKINPTDVYISYLPLAHIfervvEALFLYHG 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 271 AAwiaraplILTHRFDPAATLDAIEEHRAEFTIGAITVF-----------------IALLHHAdATREKLATLTK----- 328
Cdd:cd05927 185 AK-------IGFYSGDIRLLLDDIKALKPTVFPGVPRVLnriydkifnkvqakgplKRKLFNF-ALNYKLAELRSgvvra 256
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 329 ----------------------IYSGGAPIAPSVVEAFRAKFG-HVIHGaYGLTETNSPTHMvplarTAPVDPHSGALam 385
Cdd:cd05927 257 spfwdklvfnkikqalggnvrlMLTGSAPLSPEVLEFLRVALGcPVLEG-YGQTECTAGATL-----TLPGDTSVGHV-- 328
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 386 GVPVPGAEAAIVD-DDGNMLAAGE--TGEIVCRGPMVVPGYWNNAAATADAFR-GGWFHTGDVGFMDEAGWFYLVDRKKD 461
Cdd:cd05927 329 GGPLPCAEVKLVDvPEMNYDAKDPnpRGEVCIRGPNVFSGYYKDPEKTAEALDeDGWLHTGDIGEWLPNGTLKIIDRKKN 408
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 462 MIN-AAGYKVWPREVEDVLYGHPAVREAAVVG-----------VPDPyrgETVKAVVSLRAGAVADAAEL---------- 519
Cdd:cd05927 409 IFKlSQGEYVAPEKIENIYARSPFVAQIFVYGdslksflvaivVPDP---DVLKEWAASKGGGTGSFEELcknpevkkai 485
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 1595048490 520 -----IAFCKARMAAYKYPRIVEFRDELPK------TATGKILRRELR 556
Cdd:cd05927 486 ledlvRLGKENGLKGFEQVKAIHLEPEPFSvengllTPTFKLKRPQLK 533
|
|
| PRK05691 |
PRK05691 |
peptide synthase; Validated |
29-555 |
4.38e-26 |
|
peptide synthase; Validated
Pssm-ID: 235564 [Multi-domain] Cd Length: 4334 Bit Score: 113.72 E-value: 4.38e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 29 LDMFAAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNP 108
Cdd:PRK05691 1134 PELLNEQARQTPERIALVWDGGSLDYAELHAQANRLAHYLRDKGVGPDVCVAIAAERSPQLLVGLLAILKAGGAYVPLDP 1213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 109 MNRARELKLLLDDSQARVLICDAALegevvreviasieaegnaaprvfttraralqtrddprvFGTQREASGAGEGARDL 188
Cdd:PRK05691 1214 DYPAERLAYMLADSGVELLLTQSHL--------------------------------------LERLPQAEGVSAIALDS 1255
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 189 LQAAQ-AVQPgrkpPPVVLAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPL-FHITglV 266
Cdd:PRK05691 1256 LHLDSwPSQA----PGLHLHGDNLAYVIYTSGSTGQPKGVGNTHAALAERLQWMQATYALDDSDVLMQKAPIsFDVS--V 1329
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 267 GHIGAAWIARAPLILT----HRfDPAATLDAIEEHRA---EFTIGAITVFIALLHHADATReklatLTKIYSGGAPIAPS 339
Cdd:PRK05691 1330 WECFWPLITGCRLVLAgpgeHR-DPQRIAELVQQYGVttlHFVPPLLQLFIDEPLAAACTS-----LRRLFSGGEALPAE 1403
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 340 VVEAFRAKFGHV-IHGAYGLTETN-SPTHMVPLARTAPVDPhsgalaMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGP 417
Cdd:PRK05691 1404 LRNRVLQRLPQVqLHNRYGPTETAiNVTHWQCQAEDGERSP------IGRPLGNVLCRVLDAELNLLPPGVAGELCIGGA 1477
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 418 MVVPGYWNNAAATADAF------RGG--WFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAA 489
Cdd:PRK05691 1478 GLARGYLGRPALTAERFvpdplgEDGarLYRTGDRARWNADGALEYLGRLDQQVKLRGFRVEPEEIQARLLAQPGVAQAA 1557
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1595048490 490 VVgVPDPYRGETVKAVVSLRAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRREL 555
Cdd:PRK05691 1558 VL-VREGAAGAQLVGYYTGEAGQEAEAERLKAALAAELPEYMVPAQLIRLDQMPLGPSGKLDRRAL 1622
|
|
| hsFATP4_like |
cd05939 |
Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins; Fatty ... |
49-556 |
4.03e-25 |
|
Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins; Fatty acid transport protein (FATP) transports long-chain or very-long-chain fatty acids across the plasma membrane. At least five copies of FATPs are identified in mammalian cells. This family includes FATP4, FATP1, and homologous proteins. Each FATP has unique patterns of tissue distribution. FATP4 is mainly expressed in the brain, testis, colon and kidney. FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. FATPs are the key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis.
Pssm-ID: 341262 [Multi-domain] Cd Length: 474 Bit Score: 108.67 E-value: 4.03e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 49 DGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNpmnrarelklllddsqarvli 128
Cdd:cd05939 1 DRHWTFRELNEYSNKVANFFQAQGYRSGDVVALFMENRLEFVALWLGLAKIGVETALIN--------------------- 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 129 cdAALEGEVVREVIAsieaegnaaprvfTTRARALQTrddprvfgtqreasgagegarDLLQAAQAVQPGRKPPPVVLAA 208
Cdd:cd05939 60 --SNLRLESLLHCIT-------------VSKAKALIF---------------------NLLDPLLTQSSTEPPSQDDVNF 103
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 209 SDPAMLVYTSGTSGRPKGAICTHGNFAFNSQ-TYRDFcGLREGGPILGVAPLFHITGLVGHIGAAWIARAPLILTHRFDP 287
Cdd:cd05939 104 RDKLFYIYTSGTTGLPKAAVIVHSRYYRIAAgAYYAF-GMRPEDVVYDCLPLYHSAGGIMGVGQALLHGSTVVIRKKFSA 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 288 AATLDAIEEHRAEFT--IGAITVFiaLLHHADATREKLATLTKIYSGGapIAPSVVEAFRAKFG-HVIHGAYGLTETNS- 363
Cdd:cd05939 183 SNFWDDCVKYNCTIVqyIGEICRY--LLAQPPSEEEQKHNVRLAVGNG--LRPQIWEQFVRRFGiPQIGEFYGATEGNSs 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 364 -----------------PTHMVPLaRTAPVDPHSGALamgvpvpgaeaaIVDDDGNMLAA--GETGEIVCRGPMVVP--- 421
Cdd:cd05939 259 lvnidnhvgacgfnsriLPSVYPI-RLIKVDEDTGEL------------IRDSDGLCIPCqpGEPGLLVGKIIQNDPlrr 325
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 422 --GYWNNAAATA----DAFRGG--WFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGV 493
Cdd:cd05939 326 fdGYVNEGATNKkiarDVFKKGdsAFLSGDVLVMDELGYLYFKDRTGDTFRWKGENVSTTEVEGILSNVLGLEDVVVYGV 405
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1595048490 494 PDPYrgetvkavVSLRAG--AVADAAE------LIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:cd05939 406 EVPG--------VEGRAGmaAIVDPERkvdldrFSAVLAKSLPPYARPQFIRLLPEVDKTGTFKLQKTDLQ 468
|
|
| PRK07445 |
PRK07445 |
O-succinylbenzoic acid--CoA ligase; Reviewed |
190-556 |
1.68e-24 |
|
O-succinylbenzoic acid--CoA ligase; Reviewed
Pssm-ID: 236019 [Multi-domain] Cd Length: 452 Bit Score: 106.23 E-value: 1.68e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 190 QAAQAVQP----GRKPPPVVLAASDPA-----------MLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCglrEGGPI- 253
Cdd:PRK07445 86 QVLNLVQPdqiwGLDQLKLSHPPPLPSqgilpnletgwIMIPTGGSSGQIRFAIHTWETLTASVQGFQRYF---QLQQVn 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 254 -LGVAPLFHITGLVGHIgAAWIARAPLILT--HRFDPAATLDAieeHRAEFtigaitvFIAL----LHHA-DATREKLAT 325
Cdd:PRK07445 163 sFCVLPLYHVSGLMQFM-RSFLTGGKLVILpyKRLKSGQELPP---NPSDF-------FLSLvptqLQRLlQLRPQWLAQ 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 326 LTKIYSGGAPIAPSVVEAfrAKFGHV-IHGAYGLTETNSpthMVplARTAPVDPHSGALAMGVPVPGAEAAIVdddgnml 404
Cdd:PRK07445 232 FRTILLGGAPAWPSLLEQ--ARQLQLrLAPTYGMTETAS---QI--ATLKPDDFLAGNNSSGQVLPHAQITIP------- 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 405 aAGETGEIVCRGPMVVPGYWNNAAATAdafrgGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPA 484
Cdd:PRK07445 298 -ANQTGNITIQAQSLALGYYPQILDSQ-----GIFETDDLGYLDAQGYLHILGRNSQKIITGGENVYPAEVEAAILATGL 371
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1595048490 485 VREAAVVGVPDPYRGETVKAVVSLRAGAVaDAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:PRK07445 372 VQDVCVLGLPDPHWGEVVTAIYVPKDPSI-SLEELKTAIKDQLSPFKQPKHWIPVPQLPRNPQGKINRQQLQ 442
|
|
| PRK09029 |
PRK09029 |
O-succinylbenzoic acid--CoA ligase; Provisional |
37-556 |
1.83e-22 |
|
O-succinylbenzoic acid--CoA ligase; Provisional
Pssm-ID: 236363 [Multi-domain] Cd Length: 458 Bit Score: 100.33 E-value: 1.83e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 37 ERAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELK 116
Cdd:PRK09029 14 QVRPQAIALRLNDEVLTWQQLCARIDQLAAGFAQQGVVEGSGVALRGKNSPETLLAYLALLQCGARVLPLNPQLPQPLLE 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 117 LLLDDSQARVLICDAalegevvreviasieaegnaaprvfttraralqtrddprvfgtqreasgaGEGARDLLQAAQaVQ 196
Cdd:PRK09029 94 ELLPSLTLDFALVLE--------------------------------------------------GENTFSALTSLH-LQ 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 197 PGRKPPPVVLAASDPAMLVYTSGTSGRPKGAICTHGN-----------FAFNSQ-TYrdfcglreggpiLGVAPLFHITG 264
Cdd:PRK09029 123 LVEGAHAVAWQPQRLATMTLTSGSTGLPKAAVHTAQAhlasaegvlslMPFTAQdSW------------LLSLPLFHVSG 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 265 LvGhIGAAWIARAplilthrfdpaATLDAIEEHRAEFTIGAITvfiallhHA-----------DATREKLaTLTKIYSGG 333
Cdd:PRK09029 191 Q-G-IVWRWLYAG-----------ATLVVRDKQPLEQALAGCT-------HAslvptqlwrllDNRSEPL-SLKAVLLGG 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 334 APIAPSVVEAFRAKfGHVIHGAYGLTEtnspthmvpLARTA---PVDPHSGAlamGVPVPGAEAAIVDDdgnmlaagetg 410
Cdd:PRK09029 250 AAIPVELTEQAEQQ-GIRCWCGYGLTE---------MASTVcakRADGLAGV---GSPLPGREVKLVDG----------- 305
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 411 EIVCRGPMVVPGYWNNAAATADAFRGGWFHTGDVGFMDEAGWfYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAV 490
Cdd:PRK09029 306 EIWLRGASLALGYWRQGQLVPLVNDEGWFATRDRGEWQNGEL-TILGRLDNLFFSGGEGIQPEEIERVINQHPLVQQVFV 384
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1595048490 491 VGVPDPYRGETVKAVVSLRAGavADAAELIAFCKARMAAYKYPrIVEFRdeLPKT-ATG--KILRRELR 556
Cdd:PRK09029 385 VPVADAEFGQRPVAVVESDSE--AAVVNLAEWLQDKLARFQQP-VAYYL--LPPElKNGgiKISRQALK 448
|
|
| A_NRPS_ApnA-like |
cd17644 |
similar to adenylation domain of anabaenopeptin synthetase (ApnA); This family of the ... |
31-555 |
6.35e-22 |
|
similar to adenylation domain of anabaenopeptin synthetase (ApnA); This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes Planktothrix agardhii anabaenopeptin synthetase (ApnA A1), which is capable of activating two chemically distinct amino acids (Arg and Tyr). Structural studies show that the architecture of the active site forces Arg to adopt a Tyr-like conformation, thus explaining the bispecificity. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341299 [Multi-domain] Cd Length: 465 Bit Score: 98.66 E-value: 6.35e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 31 MFAAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMN 110
Cdd:cd17644 5 LFEEQVERTPDAVAVVFEDQQLTYEELNTKANQLAHYLQSLGVKSESLVGICVERSLEMIIGLLAILKAGGAYVPLDPNY 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 111 RARELKLLLDDSQARVLIcdaalegevvreviasieaegnaaprvfttraralqtrddprvfgTQREasgagegardllq 190
Cdd:cd17644 85 PQERLTYILEDAQISVLL---------------------------------------------TQPE------------- 106
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 191 aaqavqpgrkpppvvlaasDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPL-FHITglVGHI 269
Cdd:cd17644 107 -------------------NLAYVIYTSGSTGKPKGVMIEHQSLVNLSHGLIKEYGITSSDRVLQFASIaFDVA--AEEI 165
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 270 GAAWIARAPLIL---THRFDPAATLDAIEEHRaeftigaITVF---IALLHH--ADATREKLA---TLTKIYSGGAPIAP 338
Cdd:cd17644 166 YVTLLSGATLVLrpeEMRSSLEDFVQYIQQWQ-------LTVLslpPAYWHLlvLELLLSTIDlpsSLRLVIVGGEAVQP 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 339 SVVEAFRAKFGHVIH--GAYGLTETNSPTHMVPLarTAPVDPHSGALAMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRG 416
Cdd:cd17644 239 ELVRQWQKNVGNFIQliNVYGPTEATIAATVCRL--TQLTERNITSVPIGRPIANTQVYILDENLQPVPVGVPGELHIGG 316
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 417 PMVVPGYWNNAAATADAFRGGWFH---------TGDVGfmdeagwFYLVD-------RKKDMINAAGYKVWPREVEDVLY 480
Cdd:cd17644 317 VGLARGYLNRPELTAEKFISHPFNsseserlykTGDLA-------RYLPDgnieylgRIDNQVKIRGFRIELGEIEAVLS 389
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1595048490 481 GHPAVREAAVVGVPDPYRGETVKAVVSLRAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRREL 555
Cdd:cd17644 390 QHNDVKTAVVIVREDQPGNKRLVAYIVPHYEESPSTVELRQFLKAKLPDYMIPSAFVVLEELPLTPNGKIDRRAL 464
|
|
| entF |
PRK10252 |
enterobactin non-ribosomal peptide synthetase EntF; |
30-555 |
1.01e-21 |
|
enterobactin non-ribosomal peptide synthetase EntF;
Pssm-ID: 236668 [Multi-domain] Cd Length: 1296 Bit Score: 99.73 E-value: 1.01e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 30 DMFAAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPM 109
Cdd:PRK10252 462 ALVAQQAAKTPDAPALADARYQFSYREMREQVVALANLLRERGVKPGDSVAVALPRSVFLTLALHAIVEAGAAWLPLDTG 541
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 110 NRARELKLLLDDSQARVLICDAALEGEVvreviasieaegNAAPRVFTTRARALQTRDDPRvfgtqreasgagegardll 189
Cdd:PRK10252 542 YPDDRLKMMLEDARPSLLITTADQLPRF------------ADVPDLTSLCYNAPLAPQGAA------------------- 590
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 190 qaaqavqPGRKPPPvvlaaSDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPL-FHITglVGH 268
Cdd:PRK10252 591 -------PLQLSQP-----HHTAYIIFTSGSTGRPKGVMVGQTAIVNRLLWMQNHYPLTADDVVLQKTPCsFDVS--VWE 656
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 269 IGAAWIARAPLIL----THRfDPAATLDAIEEHR---AEFTIGAITVFIALLHHADATReKLATLTKIYSGGAPIAPSVV 341
Cdd:PRK10252 657 FFWPFIAGAKLVMaepeAHR-DPLAMQQFFAEYGvttTHFVPSMLAAFVASLTPEGARQ-SCASLRQVFCSGEALPADLC 734
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 342 EAFRAKFGHVIHGAYGLTETNSPTHMVPLARTAPVDPHSGALAMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVVP 421
Cdd:PRK10252 735 REWQQLTGAPLHNLYGPTEAAVDVSWYPAFGEELAAVRGSSVPIGYPVWNTGLRILDARMRPVPPGVAGDLYLTGIQLAQ 814
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 422 GYWNNAAATA-----DAFRGG--WFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVP 494
Cdd:PRK10252 815 GYLGRPDLTAsrfiaDPFAPGerMYRTGDVARWLDDGAVEYLGRSDDQLKIRGQRIELGEIDRAMQALPDVEQAVTHACV 894
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1595048490 495 DPYRGET-------VKAVVSlRAGAVADAAELIAFCKARMAAYKYPRIVEFRDELPKTATGKILRREL 555
Cdd:PRK10252 895 INQAAATggdarqlVGYLVS-QSGLPLDTSALQAQLRERLPPHMVPVVLLQLDQLPLSANGKLDRKAL 961
|
|
| PTZ00216 |
PTZ00216 |
acyl-CoA synthetase; Provisional |
68-482 |
2.45e-21 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 240316 [Multi-domain] Cd Length: 700 Bit Score: 98.12 E-value: 2.45e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 68 LLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPmNRARE-LKLLLDDSQARVLICDaaleGEVVREVIASI- 145
Cdd:PTZ00216 138 LAELGLTKGSNVAIYEETRWEWLASIYGIWSQSMVAATVYA-NLGEDaLAYALRETECKAIVCN----GKNVPNLLRLMk 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 146 EAEGNAAPRVFTTRARALQTRDDPRVFG-TQREASGAGEGARdllqaaqavqpgrKPPPVVLAASDPAMLVYTSGTSGRP 224
Cdd:PTZ00216 213 SGGMPNTTIIYLDSLPASVDTEGCRLVAwTDVVAKGHSAGSH-------------HPLNIPENNDDLALIMYTSGTTGDP 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 225 KGAICTHGNFA--FNSQTYR--DFCG-LREGGPILGVAPLFHITGL-VGHIgaaWIARAPLI-------LTHRF-DPAAT 290
Cdd:PTZ00216 280 KGVMHTHGSLTagILALEDRlnDLIGpPEEDETYCSYLPLAHIMEFgVTNI---FLARGALIgfgsprtLTDTFaRPHGD 356
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 291 LdaiEEHRAEFTIGAITVFIAL------------------LHHADATRekLATLTK------------------------ 328
Cdd:PTZ00216 357 L---TEFRPVFLIGVPRIFDTIkkaveaklppvgslkrrvFDHAYQSR--LRALKEgkdtpywnekvfsapravlggrvr 431
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 329 -IYSGGAPIAPSVVEAFRAKFGHVIHGaYGLTET--NSPTHmvplaRTAPVDPHsgalAMGVPVPGAEAAIVDDDGnmla 405
Cdd:PTZ00216 432 aMLSGGGPLSAATQEFVNVVFGMVIQG-WGLTETvcCGGIQ-----RTGDLEPN----AVGQLLKGVEMKLLDTEE---- 497
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 406 AGET------GEIVCRGPMVVPGYWNNAAATADAF-RGGWFHTGDVGFMDEAGWFYLVDRKKDMI-NAAGYKVwPREVED 477
Cdd:PTZ00216 498 YKHTdtpeprGEILLRGPFLFKGYYKQEELTREVLdEDGWFHTGDVGSIAANGTLRIIGRVKALAkNCLGEYI-ALEALE 576
|
....*
gi 1595048490 478 VLYGH 482
Cdd:PTZ00216 577 ALYGQ 581
|
|
| PLN02736 |
PLN02736 |
long-chain acyl-CoA synthetase |
196-528 |
6.42e-21 |
|
long-chain acyl-CoA synthetase
Pssm-ID: 178337 [Multi-domain] Cd Length: 651 Bit Score: 96.71 E-value: 6.42e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 196 QPGRKPPPvvlaaSDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHI----TGLVG-HIG 270
Cdd:PLN02736 213 QPFRPPKP-----EDVATICYTSGTTGTPKGVVLTHGNLIANVAGSSLSTKFYPSDVHISYLPLAHIyervNQIVMlHYG 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 271 AAwiaraplILTHRFDPAATLDAIEEHRAefTI------------GAITVFI--------ALLHHA-------------- 316
Cdd:PLN02736 288 VA-------VGFYQGDNLKLMDDLAALRP--TIfcsvprlynriyDGITNAVkesgglkeRLFNAAynakkqalengknp 358
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 317 ---------DATREKLATLTK-IYSGGAPIAPSVVEAFRAKFGHVIHGAYGLTETNSpthmvPLARTAPVDPHSGALamG 386
Cdd:PLN02736 359 spmwdrlvfNKIKAKLGGRVRfMSSGASPLSPDVMEFLRICFGGRVLEGYGMTETSC-----VISGMDEGDNLSGHV--G 431
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 387 VPVPGAEAAIVD-DDGNMLAAGET---GEIVCRGPMVVPGYWNNAAATADAFRG-GWFHTGDVGFMDEAGWFYLVDRKKD 461
Cdd:PLN02736 432 SPNPACEVKLVDvPEMNYTSEDQPyprGEICVRGPIIFKGYYKDEVQTREVIDEdGWLHTGDIGLWLPGGRLKIIDRKKN 511
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1595048490 462 MIN-AAGYKVWPREVEDV-----------LYGHPAVREAAVVGVPDPyrgETVKAVVSLRAGAVADAAELIAFCKARMA 528
Cdd:PLN02736 512 IFKlAQGEYIAPEKIENVyakckfvaqcfVYGDSLNSSLVAVVVVDP---EVLKAWAASEGIKYEDLKQLCNDPRVRAA 587
|
|
| AFD_CAR-like |
cd17632 |
adenylation domain of carboxylic acid reductase (CAR); This family contains the adenylation ... |
70-537 |
5.24e-20 |
|
adenylation domain of carboxylic acid reductase (CAR); This family contains the adenylation domain of carboxylic acid reductase enzymes (CARs), and performs an equivalent function to that of the ANL superfamily of adenylating enzymes. It takes a carboxylic acid substrate and ATP, and produces an AMP-acyl phosphoester intermediate, releasing pyrophosphate. Kinetic analysis using various substrates shows that this enzyme has a broad but similar substrate specificity, preferring electron-rich acids. This suggests that attack by the carboxylate on the alpha-phosphate of adenosine triphosphate (ATP) is the step that determines the substrate specificity and reaction kinetics. CAR is an important enzyme for use as a biocatalyst providing regiospecific route to aldehydes from their respective carboxylic acids.
Pssm-ID: 341287 [Multi-domain] Cd Length: 588 Bit Score: 93.67 E-value: 5.24e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 70 DEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLICDAALEGEVVREViasieAEG 149
Cdd:cd17632 87 EQPVRPGDFVAVLGFTSPDYATVDLALTRLGAVSVPLQAGASAAQLAPILAETEPRLLAVSAEHLDLAVEAV-----LEG 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 150 NAAPR--VFTTRARALQTRDDprVFGTQREASGAGEGARDLLQAAQAVQPGRKPPPVVLAASD--PAMLVYTSGTSGRPK 225
Cdd:cd17632 162 GTPPRlvVFDHRPEVDAHRAA--LESARERLAAVGIPVTTLTLIAVRGRDLPPAPLFRPEPDDdpLALLIYTSGSTGTPK 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 226 GAICTHGNFAfnsQTYRDFCGLREGGPILGVA----PLFHITG---LVGHI---GAAWIARAPLILThRFDPAATLDAIE 295
Cdd:cd17632 240 GAMYTERLVA---TFWLKVSSIQDIRPPASITlnfmPMSHIAGrisLYGTLargGTAYFAAASDMST-LFDDLALVRPTE 315
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 296 -------------EHRAEFTIGAITVFIALLHHADAT---REKL--ATLTKIYSGGAPIAPSVVEAFRAKFGHVIHGAYG 357
Cdd:cd17632 316 lflvprvcdmlfqRYQAELDRRSVAGADAETLAERVKaelRERVlgGRLLAAVCGSAPLSAEMKAFMESLLDLDLHDGYG 395
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 358 LTETNSPTHMVPLARTAPVD------PHSGALAMGVPVPgaeaaivdddgnmlaageTGEIVCRGPMVVPGYWNNAAATA 431
Cdd:cd17632 396 STEAGAVILDGVIVRPPVLDyklvdvPELGYFRTDRPHP------------------RGELLVKTDTLFPGYYKRPEVTA 457
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 432 DAF-RGGWFHTGDVgfMDEAG--WFYLVDRKKDMIN-AAGYKVWPREVEDVLYGHPAVRE-------------AAVVGVP 494
Cdd:cd17632 458 EVFdEDGFYRTGDV--MAELGpdRLVYVDRRNNVLKlSQGEFVTVARLEAVFAASPLVRQifvygnserayllAVVVPTQ 535
|
490 500 510 520
....*....|....*....|....*....|....*....|....*
gi 1595048490 495 DPYRGETVKAvvsLRAgAVADAAELIAFcKARMAAYKYPR--IVE 537
Cdd:cd17632 536 DALAGEDTAR---LRA-ALAESLQRIAR-EAGLQSYEIPRdfLIE 575
|
|
| ACSBG_like |
cd05933 |
Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS); This family of very ... |
63-542 |
6.61e-19 |
|
Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS); This family of very long-chain fatty acid CoA synthetase is named bubblegum because Drosophila melanogaster mutant bubblegum (BGM) has elevated levels of very-long-chain fatty acids (VLCFA) caused by a defective gene of this family. The human homolog (hsBG) has been characterized as a very long chain fatty acid CoA synthetase that functions specifically in the brain; hsBG may play a central role in brain VLCFA metabolism and myelinogenesis. VL-FACS is involved in the first reaction step of very long chain fatty acid degradation. It catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.
Pssm-ID: 341256 [Multi-domain] Cd Length: 596 Bit Score: 90.11 E-value: 6.61e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 63 RIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLICDAALEGEVVREVI 142
Cdd:cd05933 20 QAAKAFLKLGLERFHGVGILGFNSPEWFIAAVGAIFAGGIAVGIYTTNSPEACQYVAETSEANILVVENQKQLQKILQIQ 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 143 ASIeaegnaaPRVfttRArALQTRDD-----PRVFGTQREASGAGEGARDLLQAAQAVQpgrkpppvvlAASDPAMLVYT 217
Cdd:cd05933 100 DKL-------PHL---KA-IIQYKEPlkekePNLYSWDEFMELGRSIPDEQLDAIISSQ----------KPNQCCTLIYT 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 218 SGTSGRPKGAICTHGNFAFN----SQTYRDFCGLREGGPILGVAPLFHI--------TGLVgHIGAAWIA-----RAPLI 280
Cdd:cd05933 159 SGTTGMPKGVMLSHDNITWTakaaSQHMDLRPATVGQESVVSYLPLSHIaaqildiwLPIK-VGGQVYFAqpdalKGTLV 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 281 LTHR-FDPAATL------DAIEEHRAEFTIGAITVFIALLHHADA------------------------------TREKL 323
Cdd:cd05933 238 KTLReVRPTAFMgvprvwEKIQEKMKAVGAKSGTLKRKIASWAKGvgletnlklmggespsplfyrlakklvfkkVRKAL 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 324 --ATLTKIYSGGAPIAPSVVEAFRAkFGHVIHGAYGLTETNSPthmvplaRTAPVDPHSGALAMGVPVPGAEAAIV--DD 399
Cdd:cd05933 318 glDRCQKFFTGAAPISRETLEFFLS-LNIPIMELYGMSETSGP-------HTISNPQAYRLLSCGKALPGCKTKIHnpDA 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 400 DGNmlaagetGEIVCRGPMVVPGYWNNAAATADAF-RGGWFHTGDVGFMDEAGWFYLVDRKKDMI-NAAGYKVWPREVED 477
Cdd:cd05933 390 DGI-------GEICFWGRHVFMGYLNMEDKTEEAIdEDGWLHSGDLGKLDEDGFLYITGRIKELIiTAGGENVPPVPIED 462
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1595048490 478 -VLYGHPAVREAAVVGVPDPYRGE--TVKAVVSLRAGAVADA--AELIAFC-KARMAAYKYPRIVEFRDEL 542
Cdd:cd05933 463 aVKKELPIISNAMLIGDKRKFLSMllTLKCEVNPETGEPLDEltEEAIEFCrKLGSQATRVSEIAGGKDPK 533
|
|
| PRK05851 |
PRK05851 |
long-chain-fatty acid--ACP ligase MbtM; |
33-556 |
1.78e-18 |
|
long-chain-fatty acid--ACP ligase MbtM;
Pssm-ID: 180289 [Multi-domain] Cd Length: 525 Bit Score: 88.67 E-value: 1.78e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 33 AAALERAPHESA--LLYFDG------RLDWQALDAWSDRIACLLLDegvqRGDRVALYLQNVP--QFVMALLGIWKAGAV 102
Cdd:PRK05851 5 AAALSDAMTASGrdLVVLDResglwrRHPWPEVHGRAENVAARLLD----RDRPGAVGLVGEPtvELVAAIQGAWLAGAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 103 MVPVNPMNRARELKLLLDDSQARVLicdaaleGEVVREVIASIEAEGNAAPRVFttrarALQTRDDPRVFGTQREASgag 182
Cdd:PRK05851 81 VSILPGPVRGADDGRWADATLTRFA-------GIGVRTVLSHGSHLERLRAVDS-----SVTVHDLATAAHTNRSAS--- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 183 egardllqaaqavqpgrKPPPvvlAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLrEGGPILGVA--PLF 260
Cdd:PRK05851 146 -----------------LTPP---DSGGPAVLQGTAGSTGTPRTAILSPGAVLSNLRGLNARVGL-DAATDVGCSwlPLY 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 261 HITGLVGHIGAAWiARAPLIL--THRF--DPAATLDAIEEHRAEFTIGAITVFIALLHHADATRE-KLATLTKIYSGGAP 335
Cdd:PRK05851 205 HDMGLAFLLTAAL-AGAPLWLapTTAFsaSPFRWLSWLSDSRATLTAAPNFAYNLIGKYARRVSDvDLGALRVALNGGEP 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 336 IAPSVVEAF---RAKFGH---VIHGAYGLTETNSpthmvplARTAPVdPHSGALA----------------MGVPVPGAE 393
Cdd:PRK05851 284 VDCDGFERFataMAPFGFdagAAAPSYGLAESTC-------AVTVPV-PGIGLRVdevttddgsgarrhavLGNPIPGME 355
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 394 AAIVDDDGNMLAAG-ETGEIVCRGPMVVPGYWnnAAATADafRGGWFHTGDVGFMDEAGwFYLVDRKKDMINAAGYKVWP 472
Cdd:PRK05851 356 VRISPGDGAAGVAGrEIGEIEIRGASMMSGYL--GQAPID--PDDWFPTGDLGYLVDGG-LVVCGRAKELITVAGRNIFP 430
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 473 REVEDVLYGHPAVREAAVVGVPDPYRGETVKAVVSLR-AGAVADAA--ELIafckARMAAY--KYPRIVEFRD--ELPKT 545
Cdd:PRK05851 431 TEIERVAAQVRGVREGAVVAVGTGEGSARPGLVIAAEfRGPDEAGArsEVV----QRVASEcgVVPSDVVFVApgSLPRT 506
|
570
....*....|.
gi 1595048490 546 ATGKILRRELR 556
Cdd:PRK05851 507 SSGKLRRLAVK 517
|
|
| PLN02430 |
PLN02430 |
long-chain-fatty-acid-CoA ligase |
19-553 |
1.96e-18 |
|
long-chain-fatty-acid-CoA ligase
Pssm-ID: 178049 [Multi-domain] Cd Length: 660 Bit Score: 88.72 E-value: 1.96e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 19 PNPQQEYTNGLDMFAAALERAPHESAL---LYFDGRLD---WQALDAWSD---RIACLLLDEGVQRGDRVALYLQNVPQF 89
Cdd:PLN02430 35 PPIDSDITTAWDIFSKSVEKYPDNKMLgwrRIVDGKVGpymWKTYKEVYEevlQIGSALRASGAEPGSRVGIYGSNCPQW 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 90 VMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLIcdaaLEGEVVREVIasiEAEGNAAPRV-----FTTraralq 164
Cdd:PLN02430 115 IVAMEACAAHSLICVPLYDTLGPGAVDYIVDHAEIDFVF----VQDKKIKELL---EPDCKSAKRLkaivsFTS------ 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 165 trddprvfGTQREASGAGE-GAR-----DLLQAAQAvQPGRKPPPvvlAASDPAMLVYTSGTSGRPKGAICTHGNFA--- 235
Cdd:PLN02430 182 --------VTEEESDKASQiGVKtyswiDFLHMGKE-NPSETNPP---KPLDICTIMYTSGTSGDPKGVVLTHEAVAtfv 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 236 -----FNSQ-----TYRDFcglreggpILGVAPLFHItgLVGHIGAAWIARAPLILTHRFDPAATLDAIEEHRAEFTIGA 305
Cdd:PLN02430 250 rgvdlFMEQfedkmTHDDV--------YLSFLPLAHI--LDRMIEEYFFRKGASVGYYHGDLNALRDDLMELKPTLLAGV 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 306 ITV----------------------FIALLHH-----------------AD-----ATREKLA-TLTKIYSGGAPIAPSV 340
Cdd:PLN02430 320 PRVferihegiqkalqelnprrrliFNALYKYklawmnrgyshkkaspmADflafrKVKAKLGgRLRLLISGGAPLSTEI 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 341 VEAFRAKF-GHVIHGaYGLTETNSPTHMvplartAPVDPHSGALAMGVPVPGAEAAI--VDDDG-NMLAAGETGEIVCRG 416
Cdd:PLN02430 400 EEFLRVTScAFVVQG-YGLTETLGPTTL------GFPDEMCMLGTVGAPAVYNELRLeeVPEMGyDPLGEPPRGEICVRG 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 417 PMVVPGYWNNAAATADAFRGGWFHTGDVGFMDEAGWFYLVDRKKDMIN-AAGYKVWPREVEDVLYGHPAVREAAVVGvpD 495
Cdd:PLN02430 473 KCLFSGYYKNPELTEEVMKDGWFHTGDIGEILPNGVLKIIDRKKNLIKlSQGEYVALEYLENVYGQNPIVEDIWVYG--D 550
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*....
gi 1595048490 496 PYRGETVkAVVSLRAGAVADAAELIAFCKARMAAYKYPRIVEF-RDELPKTATGKILRR 553
Cdd:PLN02430 551 SFKSMLV-AVVVPNEENTNKWAKDNGFTGSFEELCSLPELKEHiLSELKSTAEKNKLRG 608
|
|
| PRK05850 |
PRK05850 |
acyl-CoA synthetase; Validated |
76-554 |
4.25e-18 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 235624 [Multi-domain] Cd Length: 578 Bit Score: 87.69 E-value: 4.25e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 76 GDRVALYlqnVPQ---FVMALLGIWKAGAVMVPVN-PMNRARE--LKLLLDDSQARVLICDAALEGEVVREVIAsieAEG 149
Cdd:PRK05850 59 GDRAVIL---APQgleYIVAFLGALQAGLIAVPLSvPQGGAHDerVSAVLRDTSPSVVLTTSAVVDDVTEYVAP---QPG 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 150 NAAPRVFttraralqtrddprvfgtqreasgagegARDLLQaaqaVQPGRKPPPVVLAASDPAMLVYTSGTSGRPKGAIC 229
Cdd:PRK05850 133 QSAPPVI----------------------------EVDLLD----LDSPRGSDARPRDLPSTAYLQYTSGSTRTPAGVMV 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 230 THGNFAFN-SQTYRDFCGLREGGPILGVA-----PLFHITGLVGHIGAAWIARAPLILTHRFD----PAATLDAIEEHRA 299
Cdd:PRK05850 181 SHRNVIANfEQLMSDYFGDTGGVPPPDTTvvswlPFYHDMGLVLGVCAPILGGCPAVLTSPVAflqrPARWMQLLASNPH 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 300 EFTIG---AITVFIALLHHADATREKLATLTKIYSGGAPIAPSVVEAFRAKFGH------VIHGAYGLTE------TNSP 364
Cdd:PRK05850 261 AFSAApnfAFELAVRKTSDDDMAGLDLGGVLGIISGSERVHPATLKRFADRFAPfnlretAIRPSYGLAEatvyvaTREP 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 365 THMVPLAR----------TAPVDPHSGALAMGVPVPGAEAA-IVDDDGNM-LAAGETGEIVCRGPMVVPGYWNNAAATAD 432
Cdd:PRK05850 341 GQPPESVRfdyeklsaghAKRCETGGGTPLVSYGSPRSPTVrIVDPDTCIeCPAGTVGEIWVHGDNVAAGYWQKPEETER 420
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 433 AF------------RGGWFHTGDVGFMDEaGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAvVGVPDPyRGE 500
Cdd:PRK05850 421 TFgatlvdpspgtpEGPWLRTGDLGFISE-GELFIVGRIKDLLIVDGRNHYPDDIEATIQEITGGRVAA-ISVPDD-GTE 497
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1595048490 501 TVKAVVSL--RAGAVADAAELIAFCKAR-MAAYKYPRIVEFRD-------ELPKTATGKILRRE 554
Cdd:PRK05850 498 KLVAIIELkkRGDSDEEAMDRLRTVKREvTSAISKSHGLSVADlvlvapgSIPITTSGKIRRAA 561
|
|
| PLN02387 |
PLN02387 |
long-chain-fatty-acid-CoA ligase family protein |
50-506 |
2.02e-17 |
|
long-chain-fatty-acid-CoA ligase family protein
Pssm-ID: 215217 [Multi-domain] Cd Length: 696 Bit Score: 85.94 E-value: 2.02e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 50 GRLDWQALDAWSDRI---ACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARV 126
Cdd:PLN02387 102 GEYEWITYGQVFERVcnfASGLVALGHNKEERVAIFADTRAEWLIALQGCFRQNITVVTIYASLGEEALCHSLNETEVTT 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 127 LICDaalegevVREV--IASIEAEgnaaprvFTTRARALQTRDDprvfGTQREASGAGEGARDLLQAAQAVQPGRKPP-- 202
Cdd:PLN02387 182 VICD-------SKQLkkLIDISSQ-------LETVKRVIYMDDE----GVDSDSSLSGSSNWTVSSFSEVEKLGKENPvd 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 203 PVVLAASDPAMLVYTSGTSGRPKGAICTHGNF-AFNSQTYRDFCGLREGGPILGVAPLFHITGLVGH-----IGAAWIAR 276
Cdd:PLN02387 244 PDLPSPNDIAVIMYTSGSTGLPKGVMMTHGNIvATVAGVMTVVPKLGKNDVYLAYLPLAHILELAAEsvmaaVGAAIGYG 323
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 277 APLILTHrfdpaaTLDAIEEHraefTIGAITVFIALLHHA---------DATREKLAT---LTK---------------- 328
Cdd:PLN02387 324 SPLTLTD------TSNKIKKG----TKGDASALKPTLMTAvpaildrvrDGVRKKVDAkggLAKklfdiaykrrlaaieg 393
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 329 -------------------------------IYSGGAPIAPSVVEAFRAKFGHVIHGAYGLTETNSPThmvplARTAPVD 377
Cdd:PLN02387 394 swfgawglekllwdalvfkkiravlggrirfMLSGGAPLSGDTQRFINICLGAPIGQGYGLTETCAGA-----TFSEWDD 468
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 378 PHSGALamGVPVPGAEAAIVD-DDGNMLAAGET---GEIVCRGPMVVPGYWNNAAATADAF----RG-GWFHTGDVGFMD 448
Cdd:PLN02387 469 TSVGRV--GPPLPCCYVKLVSwEEGGYLISDKPmprGEIVIGGPSVTLGYFKNQEKTDEVYkvdeRGmRWFYTGDIGQFH 546
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*....
gi 1595048490 449 EAGWFYLVDRKKDMIN-AAGYKVWPREVEDVLYGHPAVREAAVVGvpDPYRGETVKAVV 506
Cdd:PLN02387 547 PDGCLEIIDRKKDIVKlQHGEYVSLGKVEAALSVSPYVDNIMVHA--DPFHSYCVALVV 603
|
|
| AACS |
cd05943 |
Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); AACS is a cytosolic ligase that ... |
51-551 |
2.24e-17 |
|
Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); AACS is a cytosolic ligase that specifically activates acetoacetate to its coenzyme A ester by a two-step reaction. Acetoacetate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is the first step of the mevalonate pathway of isoprenoid biosynthesis via isopentenyl diphosphate. Isoprenoids are a large class of compounds found in all living organisms. AACS is widely distributed in bacteria, archaea and eukaryotes. In bacteria, AACS is known to exhibit an important role in the metabolism of poly-b-hydroxybutyrate, an intracellular reserve of organic carbon and chemical energy by some microorganisms. In mammals, AACS influences the rate of ketone body utilization for the formation of physiologically important fatty acids and cholesterol.
Pssm-ID: 341265 [Multi-domain] Cd Length: 629 Bit Score: 85.40 E-value: 2.24e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 51 RLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNP-------MNRARELklllddsQ 123
Cdd:cd05943 98 EVTWAELRRRVARLAAALRALGVKPGDRVAGYLPNIPEAVVAMLATASIGAIWSSCSPdfgvpgvLDRFGQI-------E 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 124 ARVLI-CDAALEG-------EVVREVIASIeaeGNAAPRVFTtraralqtrddPRVFGTQR-EASGAGEGAR--DLLQAA 192
Cdd:cd05943 171 PKVLFaVDAYTYNgkrhdvrEKVAELVKGL---PSLLAVVVV-----------PYTVAAGQpDLSKIAKALTleDFLATG 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 193 QAVQPGRKPPPVvlaaSDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDF-CGLREGGPILGVAPL------FHITGL 265
Cdd:cd05943 237 AAGELEFEPLPF----DHPLYILYSSGTTGLPKCIVHGAGGTLLQHLKEHILhCDLRPGDRLFYYTTCgwmmwnWLVSGL 312
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 266 VghIGAAWIAR--APLilthRFDPAATLDAIEEHRAEFtIGAITVFIALLHHAD---ATREKLATLTKIYSGGAPIAPSV 340
Cdd:cd05943 313 A--VGATIVLYdgSPF----YPDTNALWDLADEEGITV-FGTSAKYLDALEKAGlkpAETHDLSSLRTILSTGSPLKPES 385
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 341 VEAFRAKFGHVIHGAYGLTETNSPTHMVPLARTAPVdpHSGALAmgVPVPGAEAAIVDDDGNMLAaGETGEIVCRGPMvv 420
Cdd:cd05943 386 FDYVYDHIKPDVLLASISGGTDIISCFVGGNPLLPV--YRGEIQ--CRGLGMAVEAFDEEGKPVW-GEKGELVCTKPF-- 458
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 421 P----GYWNNA------AATADAFRGGWFHtGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAV 490
Cdd:cd05943 459 PsmpvGFWNDPdgsryrAAYFAKYPGVWAH-GDWIEITPRGGVVILGRSDGTLNPGGVRIGTAEIYRVVEKIPEVEDSLV 537
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1595048490 491 VGVPDPYRGETVKAVVSLRAGAVADaAELIAFCKARMAAYKYPRIVEFR----DELPKTATGKIL 551
Cdd:cd05943 538 VGQEWKDGDERVILFVKLREGVELD-DELRKRIRSTIRSALSPRHVPAKiiavPDIPRTLSGKKV 601
|
|
| PTZ00237 |
PTZ00237 |
acetyl-CoA synthetase; Provisional |
204-552 |
5.59e-16 |
|
acetyl-CoA synthetase; Provisional
Pssm-ID: 240325 [Multi-domain] Cd Length: 647 Bit Score: 80.94 E-value: 5.59e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 204 VVLAASDPAMLVYTSGTSGRPKGAICTHG------NFAFNSQTYRDFCGLREGGPILGVApLFH--ITGLVGHiGAAWIA 275
Cdd:PTZ00237 249 VPVESSHPLYILYTSGTTGNSKAVVRSNGphlvglKYYWRSIIEKDIPTVVFSHSSIGWV-SFHgfLYGSLSL-GNTFVM 326
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 276 RAPLILTHRFDPAATLDAIEEHRAE-FTIGAITVFIALLHHADATREK----LATLTKIYSGGAPIAPSVVEAFRAKFGH 350
Cdd:PTZ00237 327 FEGGIIKNKHIEDDLWNTIEKHKVThTLTLPKTIRYLIKTDPEATIIRskydLSNLKEIWCGGEVIEESIPEYIENKLKI 406
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 351 VIHGAYGLTETNSpthMVPLARTAPVDPHSgalAMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPMVvPGYWNNAAAT 430
Cdd:PTZ00237 407 KSSRGYGQTEIGI---TYLYCYGHINIPYN---ATGVPSIFIKPSILSEDGKELNVNEIGEVAFKLPMP-PSFATTFYKN 479
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 431 ADAFRG------GWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAVVGVPDPYRGETVKA 504
Cdd:PTZ00237 480 DEKFKQlfskfpGYYNSGDLGFKDENGYYTIVSRSDDQIKISGNKVQLNTIETSILKHPLVLECCSIGIYDPDCYNVPIG 559
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1595048490 505 VVSLRAGAVADAAELIAF-------CKARMAAYKYPRIVEFRDELPKTATGKILR 552
Cdd:PTZ00237 560 LLVLKQDQSNQSIDLNKLkneinniITQDIESLAVLRKIIIVNQLPKTKTGKIPR 614
|
|
| PRK06334 |
PRK06334 |
long chain fatty acid--[acyl-carrier-protein] ligase; Validated |
210-503 |
3.20e-15 |
|
long chain fatty acid--[acyl-carrier-protein] ligase; Validated
Pssm-ID: 180533 [Multi-domain] Cd Length: 539 Bit Score: 78.32 E-value: 3.20e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 210 DPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLVGHIGAAWIARAPLILTHR-FDPA 288
Cdd:PRK06334 184 DVAVILFTSGTEKLPKGVPLTHANLLANQRACLKFFSPKEDDVMMSFLPPFHAYGFNSCTLFPLLSGVPVVFAYNpLYPK 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 289 ATLDAIEEHRAEFtIGAITVFIA-LLHHADATREKLATLTKIYSGGAPIAPSVVEAFRAKFGHV-IHGAYGLTETNspth 366
Cdd:PRK06334 264 KIVEMIDEAKVTF-LGSTPVFFDyILKTAKKQESCLPSLRFVVIGGDAFKDSLYQEALKTFPHIqLRQGYGTTECS---- 338
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 367 mvPLARTAPVDPHSGALAMGVPVPGAEAAIVDDDGNM-LAAGETGEIVCRGPMVVPGYWNNAAATADAFRGG--WFHTGD 443
Cdd:PRK06334 339 --PVITINTVNSPKHESCVGMPIRGMDVLIVSEETKVpVSSGETGLVLTRGTSLFSGYLGEDFGQGFVELGGetWYVTGD 416
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1595048490 444 VGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVL---YGHPAVREAA---VVGVPdpyrGETVK 503
Cdd:PRK06334 417 LGYVDRHGELFLKGRLSRFVKIGAEMVSLEALESILmegFGQNAADHAGplvVCGLP----GEKVR 478
|
|
| PRK07769 |
PRK07769 |
long-chain-fatty-acid--CoA ligase; Validated |
74-556 |
7.16e-15 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 181109 [Multi-domain] Cd Length: 631 Bit Score: 77.46 E-value: 7.16e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 74 QRGDRVA-LYLQNVpQFVMALLGIWKAGAVMVPV---NPMNRARELKLLLDDSQ-ARVLICDAALEGevVREVIasieae 148
Cdd:PRK07769 77 KPGDRVAiLAPQNL-DYLIAFFGALYAGRIAVPLfdpAEPGHVGRLHAVLDDCTpSAILTTTDSAEG--VRKFF------ 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 149 gnaaprvfttraRALQTRDDPRVFgtqreasgagegardllqAAQAV--QPGRKPPPVVLAASDPAMLVYTSGTSGRPKG 226
Cdd:PRK07769 148 ------------RARPAKERPRVI------------------AVDAVpdEVGATWVPPEANEDTIAYLQYTSGSTRIPAG 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 227 AICTHGNFAFNSQTYRDFCGLREGgpILGVA--PLFHITGLVGHIGAAWIARAPLILThrfdPAATLD---------AIE 295
Cdd:PRK07769 198 VQITHLNLPTNVLQVIDALEGQEG--DRGVSwlPFFHDMGLITVLLPALLGHYITFMS----PAAFVRrpgrwirelARK 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 296 EHRAEFTIGAITVFiALLHHADATREK-------LATLTKIYSGGAPIAPSVVEAFRAKFG------HVIHGAYGLTET- 361
Cdd:PRK07769 272 PGGTGGTFSAAPNF-AFEHAAARGLPKdgeppldLSNVKGLLNGSEPVSPASMRKFNEAFApyglppTAIKPSYGMAEAt 350
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 362 ---------NSPT------------HMVPLARTAP-VDPHSGALAMGVpvpgAE-AAIVD-DDGNMLAAGETGEIVCRGP 417
Cdd:PRK07769 351 lfvsttpmdEEPTviyvdrdelnagRFVEVPADAPnAVAQVSAGKVGV----SEwAVIVDpETASELPDGQIGEIWLHGN 426
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 418 MVVPGYWNNAAATADAFR------------------GGWFHTGDVG-FMDeaGWFYLVDRKKDMINAAGYKVWPREVE-D 477
Cdd:PRK07769 427 NIGTGYWGKPEETAATFQnilksrlseshaegapddALWVRTGDYGvYFD--GELYITGRVKDLVIIDGRNHYPQDLEyT 504
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 478 VLYGHPAVRE--AAVVGVP----------DPYRGETVKA--------VVSLRAgAVADAAELIAFCKARMAAYKYPRIVE 537
Cdd:PRK07769 505 AQEATKALRTgyVAAFSVPanqlpqvvfdDSHAGLKFDPedtseqlvIVAERA-PGAHKLDPQPIADDIRAAIAVRHGVT 583
|
570 580
....*....|....*....|....*.
gi 1595048490 538 FRDEL-------PKTATGKILRRELR 556
Cdd:PRK07769 584 VRDVLlvpagsiPRTSSGKIARRACR 609
|
|
| PRK05691 |
PRK05691 |
peptide synthase; Validated |
31-555 |
2.71e-14 |
|
peptide synthase; Validated
Pssm-ID: 235564 [Multi-domain] Cd Length: 4334 Bit Score: 76.36 E-value: 2.71e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 31 MFAAALERAPHESALLYFDGRLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMN 110
Cdd:PRK05691 3725 LFEAQVAAHPQRIAASCLDQQWSYAELNRAANRLGHALRAAGVGVDQPVALLAERGLDLLGMIVGSFKAGAGYLPLDPGL 3804
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 111 RARELKLLLDDSQARVLICDAAlegevvreviasieaegnaaprvftTRARALQTRDdprvfgtqreasGAGEGARDLLQ 190
Cdd:PRK05691 3805 PAQRLQRIIELSRTPVLVCSAA-------------------------CREQARALLD------------ELGCANRPRLL 3847
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 191 AAQAVQPGRKP---PPVVLAASDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPL-FHIT--- 263
Cdd:PRK05691 3848 VWEEVQAGEVAshnPGIYSGPDNLAYVIYTSGSTGLPKGVMVEQRGMLNNQLSKVPYLALSEADVIAQTASQsFDISvwq 3927
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 264 GLVGHIGAAWIARAPLILTHrfDPAATLDAIEEHRA---EFTIGAITVFIALLHHA-DATREKLATltkiysgGAPIAPS 339
Cdd:PRK05691 3928 FLAAPLFGARVEIVPNAIAH--DPQGLLAHVQAQGItvlESVPSLIQGMLAEDRQAlDGLRWMLPT-------GEAMPPE 3998
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 340 VVEAFRAKFGHV-IHGAYGLTETNSPthmVPLARTAPVDPHSGALAMGVPVPGAEAAIVDDDGNMLAAGETGEIVCRGPM 418
Cdd:PRK05691 3999 LARQWLQRYPQIgLVNAYGPAECSDD---VAFFRVDLASTRGSYLPIGSPTDNNRLYLLDEALELVPLGAVGELCVAGTG 4075
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 419 VVPGYWNNAAATADAFRGGWF--------HTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAv 490
Cdd:PRK05691 4076 VGRGYVGDPLRTALAFVPHPFgapgerlyRTGDLARRRSDGVLEYVGRIDHQVKIRGYRIELGEIEARLHEQAEVREAA- 4154
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1595048490 491 VGVPDPYRGETVKAVVSLRAGAVADaAELIAFCKARMAA----YKYPRIVEFRDELPKTATGKILRREL 555
Cdd:PRK05691 4155 VAVQEGVNGKHLVGYLVPHQTVLAQ-GALLERIKQRLRAelpdYMVPLHWLWLDRLPLNANGKLDRKAL 4222
|
|
| PRK06814 |
PRK06814 |
acyl-[ACP]--phospholipid O-acyltransferase; |
191-550 |
4.48e-14 |
|
acyl-[ACP]--phospholipid O-acyltransferase;
Pssm-ID: 235865 [Multi-domain] Cd Length: 1140 Bit Score: 75.39 E-value: 4.48e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 191 AAQAVQPGRKPppvvlaaSDPAMLVYTSGTSGRPKGAICTHGNF---AFNSQTYRDFcglregGP---ILGVAPLFHITG 264
Cdd:PRK06814 782 FPLVYFCNRDP-------DDPAVILFTSGSEGTPKGVVLSHRNLlanRAQVAARIDF------SPedkVFNALPVFHSFG 848
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 265 LVGHIGAAWIARAPLI-----LTHRFDPAATLDAieehRAEFTIGAITVFIALLHHADATreKLATLTKIYSGGAPIAPS 339
Cdd:PRK06814 849 LTGGLVLPLLSGVKVFlypspLHYRIIPELIYDT----NATILFGTDTFLNGYARYAHPY--DFRSLRYVFAGAEKVKEE 922
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 340 VVEAFRAKFGHVIHGAYGLTET------NSPTHMVP--LARTAPvdphsGALAMGVPVPGAEaaivdddgnmlaagETGE 411
Cdd:PRK06814 923 TRQTWMEKFGIRILEGYGVTETapvialNTPMHNKAgtVGRLLP-----GIEYRLEPVPGID--------------EGGR 983
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 412 IVCRGPMVVPGYWN-NAAATADAFRGGWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVL------YGHpa 484
Cdd:PRK06814 984 LFVRGPNVMLGYLRaENPGVLEPPADGWYDTGDIVTIDEEGFITIKGRAKRFAKIAGEMISLAAVEELAaelwpdALH-- 1061
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1595048490 485 vreaAVVGVPDPYRGETvkaVVSLRAGAVADAAELIAFCKARMAAYKY-PRIVEFRDELPKTATGKI 550
Cdd:PRK06814 1062 ----AAVSIPDARKGER---IILLTTASDATRAAFLAHAKAAGASELMvPAEIITIDEIPLLGTGKI 1121
|
|
| PRK08180 |
PRK08180 |
feruloyl-CoA synthase; Reviewed |
51-450 |
1.15e-13 |
|
feruloyl-CoA synthase; Reviewed
Pssm-ID: 236175 [Multi-domain] Cd Length: 614 Bit Score: 73.76 E-value: 1.15e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 51 RLDW-QALDAwSDRIACLLLDEGVQRGDRVALYLQN-VPQFVMALLGIWkAGAVMVPVNPMN--------RARELKLLL- 119
Cdd:PRK08180 69 RLTYaEALER-VRAIAQALLDRGLSAERPLMILSGNsIEHALLALAAMY-AGVPYAPVSPAYslvsqdfgKLRHVLELLt 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 120 ------DDSQArvliCDAALEGEVV--REVIASieaEGNAAPRVFTTRARALQTRDDPRVfgtqreasgagegardlLQA 191
Cdd:PRK08180 147 pglvfaDDGAA----FARALAAVVPadVEVVAV---RGAVPGRAATPFAALLATPPTAAV-----------------DAA 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 192 AQAVQPgrkpppvvlaaSDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRD-FCGLREGGPIL-----------GVapl 259
Cdd:PRK08180 203 HAAVGP-----------DTIAKFLFTSGSTGLPKAVINTHRMLCANQQMLAQtFPFLAEEPPVLvdwlpwnhtfgGN--- 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 260 fHITGLVGHIGAawiaraplilTHRFDP--------AATLDAIEEHraeftigAITV-------FIALLHHA---DATRE 321
Cdd:PRK08180 269 -HNLGIVLYNGG----------TLYIDDgkptpggfDETLRNLREI-------SPTVyfnvpkgWEMLVPALerdAALRR 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 322 KL-ATLTKIYSGGAPIAPSVVEAF----RAKFGH--VIHGAYGLTETnSPTHM---VPLARTAPVdphsgalamGVPVPG 391
Cdd:PRK08180 331 RFfSRLKLLFYAGAALSQDVWDRLdrvaEATCGEriRMMTGLGMTET-APSATfttGPLSRAGNI---------GLPAPG 400
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1595048490 392 AEAAIVDDDGNMlaagetgEIVCRGPMVVPGYWNNAAATADAF-RGGWFHTGD-VGFMDEA 450
Cdd:PRK08180 401 CEVKLVPVGGKL-------EVRVKGPNVTPGYWRAPELTAEAFdEEGYYRSGDaVRFVDPA 454
|
|
| FCS |
cd05921 |
Feruloyl-CoA synthetase (FCS); Feruloyl-CoA synthetase is an essential enzyme in the feruloyl ... |
49-531 |
1.26e-13 |
|
Feruloyl-CoA synthetase (FCS); Feruloyl-CoA synthetase is an essential enzyme in the feruloyl acid degradation pathway and enables some proteobacteria to grow on media containing feruloyl acid as the sole carbon source. It catalyzes the transfer of CoA to the carboxyl group of ferulic acid, which then forms feruloyl-CoA in the presence of ATP and Mg2. The resulting feruloyl-CoA is further degraded to vanillin and acetyl-CoA. Feruloyl-CoA synthetase (FCS) is a subfamily of the adenylate-forming enzymes superfamily.
Pssm-ID: 341245 [Multi-domain] Cd Length: 561 Bit Score: 73.62 E-value: 1.26e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 49 DGRLDW------QALDAwSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNP----MNR-ARELKL 117
Cdd:cd05921 18 EGNGGWrrvtyaEALRQ-VRAIAQGLLDLGLSAERPLLILSGNSIEHALMALAAMYAGVPAAPVSPayslMSQdLAKLKH 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 118 LLDDSQARVLICDAAlegEVVREVIASIEAEGnaAPRVFTTraralqtrddprvfgtqreasGAGEGARDLLQAAQAVQP 197
Cdd:cd05921 97 LFELLKPGLVFAQDA---APFARALAAIFPLG--TPLVVSR---------------------NAVAGRGAISFAELAATP 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 198 GRKPPPVVLAASDP---AMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGP--ILGVAPLFHITG------LV 266
Cdd:cd05921 151 PTAAVDAAFAAVGPdtvAKFLFTSGSTGLPKAVINTQRMLCANQAMLEQTYPFFGEEPpvLVDWLPWNHTFGgnhnfnLV 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 267 GHIGAAWIARAPLILTHRFdpAATLDAIEE--HRAEFTIGA-ITVFIALLHHADATREKL-ATLTKIYSGGAPIAPSVVE 342
Cdd:cd05921 231 LYNGGTLYIDDGKPMPGGF--EETLRNLREisPTVYFNVPAgWEMLVAALEKDEALRRRFfKRLKLMFYAGAGLSQDVWD 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 343 AFRA----KFGHVI--HGAYGLTETnSPTHMV---PLARTAPVdphsgalamGVPVPGAEAAIVDDDGNMlaagetgEIV 413
Cdd:cd05921 309 RLQAlavaTVGERIpmMAGLGATET-APTATFthwPTERSGLI---------GLPAPGTELKLVPSGGKY-------EVR 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 414 CRGPMVVPGYWNNAAATADAF-RGGWFHTGDVG-FMD----EAGWFYLVDRKKDMINAAG--YKVWPREVEDVLYGHPAV 485
Cdd:cd05921 372 VKGPNVTPGYWRQPELTAQAFdEEGFYCLGDAAkLADpddpAKGLVFDGRVAEDFKLASGtwVSVGPLRARAVAACAPLV 451
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*.
gi 1595048490 486 REAAVVG----------VPDPYRGETVKAVVSLRAGAVADAAELIAFCKARMAAYK 531
Cdd:cd05921 452 HDAVVAGedraevgalvFPDLLACRRLVGLQEASDAEVLRHAKVRAAFRDRLAALN 507
|
|
| Dip2 |
cd05905 |
Disco-interacting protein 2 (Dip2); Dip2 proteins show sequence similarity to other members of ... |
52-556 |
1.31e-13 |
|
Disco-interacting protein 2 (Dip2); Dip2 proteins show sequence similarity to other members of the adenylate forming enzyme family, including insect luciferase, acetyl CoA ligases and the adenylation domain of nonribosomal peptide synthetases (NRPS). However, its function may have diverged from other members of the superfamily. In mouse embryo, Dip2 homolog A plays an important role in the development of both vertebrate and invertebrate nervous systems. Dip2A appears to regulate cell growth and the arrangement of cells in organs. Biochemically, Dip2A functions as a receptor of FSTL1, an extracellular glycoprotein, and may play a role as a cardiovascular protective agent.
Pssm-ID: 341231 [Multi-domain] Cd Length: 571 Bit Score: 73.54 E-value: 1.31e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 52 LDWQALDAWSDRIACLLLDE-GVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVLICD 130
Cdd:cd05905 15 LTWGKLLSRAEKIAAVLQKKvGLKPGDRVALMYPDPLDFVAAFYGCLYAGVVPIPIEPPDISQQLGFLLGTCKVRVALTV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 131 AALEGEVVREVIASIEAEGNAAPRVFttrARALQTRDDPRVFGTQREASGAGEGARDllqaaqavqpgrkpppvvlaaSD 210
Cdd:cd05905 95 EACLKGLPKKLLKSKTAAEIAKKKGW---PKILDFVKIPKSKRSKLKKWGPHPPTRD---------------------GD 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 211 PAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLVGHIGAAWIARAPLILTHRFD---- 286
Cdd:cd05905 151 TAYIEYSFSSDGSLSGVAVSHSSLLAHCRALKEACELYESRPLVTVLDFKSGLGLWHGCLLSVYSGHHTILIPPELmktn 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 287 PAATLDAIEEHRAEFTIGAITVFIALLHHADATREKLATLTKIYSG--------GAPIAPSVVEAF-----------RA- 346
Cdd:cd05905 231 PLLWLQTLSQYKVRDAYVKLRTLHWCLKDLSSTLASLKNRDVNLSSlrmcmvpcENRPRISSCDSFlklfqtlglspRAv 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 347 --KFGHVIHGAYGLTETNSP------------THMVPLARTApVDPHSGALAM-GVPVPGAEAAIVDDDG-NMLAAGETG 410
Cdd:cd05905 311 stEFGTRVNPFICWQGTSGPepsrvyldmralRHGVVRLDER-DKPNSLPLQDsGKVLPGAQVAIVNPETkGLCKDGEIG 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 411 EIVCRGPMVVPGYWNNAAATADAFRG-------------GWFHTGDVGF----------MDEAGWFYLVDRKKDMINAAG 467
Cdd:cd05905 390 EIWVNSPANASGYFLLDGETNDTFKVfpstrlstgitnnSYARTGLLGFlrptkctdlnVEEHDLLFVVGSIDETLEVRG 469
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 468 YKVWPREVED-VLYGHPAVREAA--------VVGVPDPYRGETVKA-VVSLRAGAVADAAELIAFCKArmaaykyprIVE 537
Cdd:cd05905 470 LRHHPSDIEAtVMRVHPYRGRCAvfsitglvVVVAEQPPGSEEEALdLVPLVLNAILEEHQVIVDCVA---------LVP 540
|
570
....*....|....*....
gi 1595048490 538 fRDELPKTATGKILRRELR 556
Cdd:cd05905 541 -PGSLPKNPLGEKQRMEIR 558
|
|
| PLN02614 |
PLN02614 |
long-chain acyl-CoA synthetase |
9-491 |
1.48e-13 |
|
long-chain acyl-CoA synthetase
Pssm-ID: 166255 [Multi-domain] Cd Length: 666 Bit Score: 73.52 E-value: 1.48e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 9 WRALYDTGIEPNPQQEYTNGLDMFAAALERAPHESALLYFD------GRLDWQALDAWSDRIACL---LLDEGVQRGDRV 79
Cdd:PLN02614 28 YRSIFAKDGFPNPIEGMDSCWDVFRMSVEKYPNNPMLGRREivdgkpGKYVWQTYQEVYDIVIKLgnsLRSVGVKDEAKC 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 80 ALYLQNVPQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDSQARVlicdAALEGEVVREVIASIEAEGNAAPRVFTTR 159
Cdd:PLN02614 108 GIYGANSPEWIISMEACNAHGLYCVPLYDTLGAGAVEFIISHSEVSI----VFVEEKKISELFKTCPNSTEYMKTVVSFG 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 160 ARALQTRDDPRVFG----TQREASGAGEGArdllqaaQAVQPGRKPppvvlaaSDPAMLVYTSGTSGRPKGAICTHGNFA 235
Cdd:PLN02614 184 GVSREQKEEAETFGlviyAWDEFLKLGEGK-------QYDLPIKKK-------SDICTIMYTSGTTGDPKGVMISNESIV 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 236 FNSQTYRDFCG-----LREGGPILGVAPLFHI------TGLVGHIGAAWIARA--------------------PLILTHR 284
Cdd:PLN02614 250 TLIAGVIRLLKsanaaLTVKDVYLSYLPLAHIfdrvieECFIQHGAAIGFWRGdvklliedlgelkptifcavPRVLDRV 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 285 ------------------FDPAATLDAIEEHRAEFTIGAITVFIALLHhaDATREKLATLTKI-YSGGAPIApSVVEAFR 345
Cdd:PLN02614 330 ysglqkklsdggflkkfvFDSAFSYKFGNMKKGQSHVEASPLCDKLVF--NKVKQGLGGNVRIiLSGAAPLA-SHVESFL 406
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 346 AKFG--HVIHGaYGLTETNSPTHMvplarTAPvDPHSGALAMGVPVPGAE---AAIVDDDGNMLAAGETGEIVCRGPMVV 420
Cdd:PLN02614 407 RVVAccHVLQG-YGLTESCAGTFV-----SLP-DELDMLGTVGPPVPNVDirlESVPEMEYDALASTPRGEICIRGKTLF 479
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1595048490 421 PGYWNNAAATADAFRGGWFHTGDVGFMDEAGWFYLVDRKKDMIN-AAGYKVWPREVEDVlYGHPAVREAAVV 491
Cdd:PLN02614 480 SGYYKREDLTKEVLIDGWLHTGDVGEWQPNGSMKIIDRKKNIFKlSQGEYVAVENIENI-YGEVQAVDSVWV 550
|
|
| PLN02861 |
PLN02861 |
long-chain-fatty-acid-CoA ligase |
317-462 |
1.40e-11 |
|
long-chain-fatty-acid-CoA ligase
Pssm-ID: 178452 [Multi-domain] Cd Length: 660 Bit Score: 67.17 E-value: 1.40e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 317 DATREKLATLTKI-YSGGAPIAPSVVEAFRAKFGHVIHGAYGLTETNSPThmvpLARTAPVDPHSGALamGVPVPGAEAA 395
Cdd:PLN02861 375 DKIKEGLGGRVRLlLSGAAPLPRHVEEFLRVTSCSVLSQGYGLTESCGGC----FTSIANVFSMVGTV--GVPMTTIEAR 448
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 396 I--VDDDG-NMLAAGETGEIVCRGPMVVPGYWNNAAATADAFRGGWFHTGDVGFMDEAGWFYLVDRKKDM 462
Cdd:PLN02861 449 LesVPEMGyDALSDVPRGEICLRGNTLFSGYHKRQDLTEEVLIDGWFHTGDIGEWQPNGAMKIIDRKKNI 518
|
|
| PRK12476 |
PRK12476 |
putative fatty-acid--CoA ligase; Provisional |
52-556 |
2.90e-11 |
|
putative fatty-acid--CoA ligase; Provisional
Pssm-ID: 171527 [Multi-domain] Cd Length: 612 Bit Score: 65.92 E-value: 2.90e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 52 LDWQALDAWSDRIACLLlDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPV---NPMNRARELKLLLDDSQARVLI 128
Cdd:PRK12476 69 LTWTQLGVRLRAVGARL-QQVAGPGDRVAILAPQGIDYVAGFFAAIKAGTIAVPLfapELPGHAERLDTALRDAEPTVVL 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 129 CDAALEgEVVREVIasieaegnaaprvfttraRALQTRDDPRVFGTQREASGAGEGARdllqaaqavqpgrkppPVVLAA 208
Cdd:PRK12476 148 TTTAAA-EAVEGFL------------------RNLPRLRRPRVIAIDAIPDSAGESFV----------------PVELDT 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 209 SDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGpILGVA--PLFHITGLV---------GHIgaawIARA 277
Cdd:PRK12476 193 DDVSHLQYTSGSTRPPVGVEITHRAVGTNLVQMILSIDLLDRN-THGVSwlPLYHDMGLSmigfpavygGHS----TLMS 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 278 PLILTHRfdPAATLDAI-EEHRAEFTIGAITVFI-------ALLHHADATreKLATLTKIySGGAPIAPSVVEAFRAKFG 349
Cdd:PRK12476 268 PTAFVRR--PQRWIKALsEGSRTGRVVTAAPNFAyewaaqrGLPAEGDDI--DLSNVVLI-IGSEPVSIDAVTTFNKAFA 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 350 ------HVIHGAYGLTE-TNSPTHMVPLA---------------RTAPVDP-HSGALAM---GVPVPGAEAAIVDDD-GN 402
Cdd:PRK12476 343 pyglprTAFKPSYGIAEaTLFVATIAPDAepsvvyldreqlgagRAVRVAAdAPNAVAHvscGQVARSQWAVIVDPDtGA 422
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 403 MLAAGETGEIVCRGPMVVPGYWNNAAATADAFR-------------------GGWFHTGDVGF-MDeaGWFYLVDRKKDM 462
Cdd:PRK12476 423 ELPDGEVGEIWLHGDNIGRGYWGRPEETERTFGaklqsrlaegshadgaaddGTWLRTGDLGVyLD--GELYITGRIADL 500
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 463 INAAGYKVWPREVE-DVLYGHPAVREAAVVGVPDPYRGETVKAVVSLRAG--AVADAAELIAFCKARMAAYKYPRIVEFR 539
Cdd:PRK12476 501 IVIDGRNHYPQDIEaTVAEASPMVRRGYVTAFTVPAEDNERLVIVAERAAgtSRADPAPAIDAIRAAVSRRHGLAVADVR 580
|
570 580
....*....|....*....|.
gi 1595048490 540 ----DELPKTATGKILRRELR 556
Cdd:PRK12476 581 lvpaGAIPRTTSGKLARRACR 601
|
|
| PRK07868 |
PRK07868 |
acyl-CoA synthetase; Validated |
38-556 |
3.25e-10 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236121 [Multi-domain] Cd Length: 994 Bit Score: 63.20 E-value: 3.25e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 38 RAPHESALLyFDGRL-DWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNP-MNRAREL 115
Cdd:PRK07868 459 DAPKGEFLL-FDGRVhTYEAVNRRINNVVRGLIAVGVRQGDRVGVLMETRPSALVAIAALSRLGAVAVLMPPdTDLAAAV 537
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 116 KLllddSQARVLICDAAlegevvreviaSIEAEGNAAPRVFTT---RARALQTRDDPRVFgtqreasgagegarDLLQ-- 190
Cdd:PRK07868 538 RL----GGVTEIITDPT-----------NLEAARQLPGRVLVLgggESRDLDLPDDADVI--------------DMEKid 588
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 191 AAQAVQPG-RKPPPVVlaASDPAMLVYtSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGLVGHI 269
Cdd:PRK07868 589 PDAVELPGwYRPNPGL--ARDLAFIAF-STAGGELVAKQITNYRWALSAFGTASAAALDRRDTVYCLTPLHHESGLLVSL 665
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 270 GAAWIARAPLILTHRFDPAATldAIEEHRAEFTIGAITvfIALLHhaDATREKLATLtkiySGGAPI-------APS--- 339
Cdd:PRK07868 666 GGAVVGGSRIALSRGLDPDRF--VQEVRQYGVTVVSYT--WAMLR--EVVDDPAFVL----HGNHPVrlfigsgMPTglw 735
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 340 --VVEAFRAkfGHVIHgAYGLTETNspthmVPLARTAPVDPHSgalaMGVPVPGA-----------EAAIVDDDGNMLAA 406
Cdd:PRK07868 736 erVVEAFAP--AHVVE-FFATTDGQ-----AVLANVSGAKIGS----KGRPLPGAgrvelaaydpeHDLILEDDRGFVRR 803
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 407 GETGEI-----VCRGPmVVPgywnNAAATADAFRGG--WFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVL 479
Cdd:PRK07868 804 AEVNEVgvllaRARGP-IDP----TASVKRGVFAPAdtWISTEYLFRRDDDGDYWLVDRRGSVIRTARGPVYTEPVTDAL 878
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1595048490 480 YGHPAVREAAVVGVPDPYRGETVKAvVSLRAGAVADAAEL-IAFckARMAAYKYPRIVEFRDELPKTATGKILRRELR 556
Cdd:PRK07868 879 GRIGGVDLAVTYGVEVGGRQLAVAA-VTLRPGAAITAADLtEAL--ASLPVGLGPDIVHVVPEIPLSATYRPTVSALR 953
|
|
| PRK03584 |
PRK03584 |
acetoacetate--CoA ligase; |
51-551 |
3.68e-10 |
|
acetoacetate--CoA ligase;
Pssm-ID: 235134 [Multi-domain] Cd Length: 655 Bit Score: 62.51 E-value: 3.68e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 51 RLDWQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALL------GIWKA-----GAVMVpvnpMNRARELKlll 119
Cdd:PRK03584 114 ELSWAELRRQVAALAAALRALGVGPGDRVAAYLPNIPETVVAMLataslgAIWSScspdfGVQGV----LDRFGQIE--- 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 120 ddsqARVLI-CDAALEG-------EVVREVIASIeaeGNAAPRVFTTRARAlqtrddprvfgtqREASGAGEGARDlLQA 191
Cdd:PRK03584 187 ----PKVLIaVDGYRYGgkafdrrAKVAELRAAL---PSLEHVVVVPYLGP-------------AAAAAALPGALL-WED 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 192 AQAVQPGRKPPPVVLAASDPAMLVYTSGTSGRPKGAICTHGnfafnsqtyrdfcG-----LREGGPILGVAPL------- 259
Cdd:PRK03584 246 FLAPAEAAELEFEPVPFDHPLWILYSSGTTGLPKCIVHGHG-------------GillehLKELGLHCDLGPGdrffwyt 312
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 260 --------FHITGLVghIGAAwiarapLIL-----THRfDPAATLDAIEEHRAEFtIGAITVFIALLHHAD---ATREKL 323
Cdd:PRK03584 313 tcgwmmwnWLVSGLL--VGAT------LVLydgspFYP-DPNVLWDLAAEEGVTV-FGTSAKYLDACEKAGlvpGETHDL 382
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 324 ATLTKIYSGGAPIAPsvvEAFRAKFGHVIHGaygltetnspthmVPLARTapvdphSG------ALAMGVP-VP------ 390
Cdd:PRK03584 383 SALRTIGSTGSPLPP---EGFDWVYEHVKAD-------------VWLASI------SGgtdicsCFVGGNPlLPvyrgei 440
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 391 -----GAEAAIVDDDGNMLaAGETGEIVCRGPMvvP----GYWNNA------AATADAFRGGWFHtGDVGFMDEAGWFYL 455
Cdd:PRK03584 441 qcrglGMAVEAWDEDGRPV-VGEVGELVCTKPF--PsmplGFWNDPdgsryrDAYFDTFPGVWRH-GDWIEITEHGGVVI 516
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 456 VDRKKDMINAAG--------YkvwpREVEDVlyghPAVREAAVVGVPDPYRGETVKAVVSLRAGAVADAAeLIAFCKARM 527
Cdd:PRK03584 517 YGRSDATLNRGGvrigtaeiY----RQVEAL----PEVLDSLVIGQEWPDGDVRMPLFVVLAEGVTLDDA-LRARIRTTI 587
|
570 580
....*....|....*....|....*....
gi 1595048490 528 AAYKYPR-----IVEFRDeLPKTATGKIL 551
Cdd:PRK03584 588 RTNLSPRhvpdkIIAVPD-IPRTLSGKKV 615
|
|
| PRK08043 |
PRK08043 |
bifunctional acyl-ACP--phospholipid O-acyltransferase/long-chain-fatty-acid--ACP ligase; |
188-549 |
4.76e-10 |
|
bifunctional acyl-ACP--phospholipid O-acyltransferase/long-chain-fatty-acid--ACP ligase;
Pssm-ID: 181207 [Multi-domain] Cd Length: 718 Bit Score: 62.42 E-value: 4.76e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 188 LLQAAQAVQPgRKPppvvlaaSDPAMLVYTSGTSGRPKGAICTHGNFAFNSQTYRDFCGLREGGPILGVAPLFHITGL-V 266
Cdd:PRK08043 352 LLMPRLAQVK-QQP-------EDAALILFTSGSEGHPKGVVHSHKSLLANVEQIKTIADFTPNDRFMSALPLFHSFGLtV 423
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 267 GHIG----AAWIARAPLILTHRFDPAATLDaieehRAEFTIGAITVFIAllHHAD-ATREKLATLTKIYSGGAPIAPSVV 341
Cdd:PRK08043 424 GLFTplltGAEVFLYPSPLHYRIVPELVYD-----RNCTVLFGTSTFLG--NYARfANPYDFARLRYVVAGAEKLQESTK 496
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 342 EAFRAKFGHVIHGAYGLTETNSPTHM-VPLArtapVDPHSgalaMGVPVPGAEAAIVDDDGnmlaAGETGEIVCRGPMVV 420
Cdd:PRK08043 497 QLWQDKFGLRILEGYGVTECAPVVSInVPMA----AKPGT----VGRILPGMDARLLSVPG----IEQGGRLQLKGPNIM 564
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 421 PGYWNN------AAATADAFRG----GWFHTGDVGFMDEAGWFYLVDRKKDMINAAGYKVWPREVEDVLYGHPAVREAAV 490
Cdd:PRK08043 565 NGYLRVekpgvlEVPTAENARGemerGWYDTGDIVRFDEQGFVQIQGRAKRFAKIAGEMVSLEMVEQLALGVSPDKQHAT 644
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 491 VGVPDPYRGEtvkAVVSLRAGAVADAAELIAFCKAR-MAAYKYPRIVEFRDELPKTATGK 549
Cdd:PRK08043 645 AIKSDASKGE---ALVLFTTDSELTREKLQQYAREHgVPELAVPRDIRYLKQLPLLGSGK 701
|
|
| alpha_am_amid |
TIGR03443 |
L-aminoadipate-semialdehyde dehydrogenase; Members of this protein family are ... |
54-487 |
2.33e-09 |
|
L-aminoadipate-semialdehyde dehydrogenase; Members of this protein family are L-aminoadipate-semialdehyde dehydrogenase (EC 1.2.1.31), product of the LYS2 gene. It is also called alpha-aminoadipate reductase. In fungi, lysine is synthesized via aminoadipate. Currently, all members of this family are fungal.
Pssm-ID: 274582 [Multi-domain] Cd Length: 1389 Bit Score: 60.46 E-value: 2.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 54 WQALDAWSDRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGA---VMVPVNPMNRArelKLLLDDSQARVLIcd 130
Cdd:TIGR03443 273 YKQINEASNILAHYLLKTGIKRGDVVMIYAYRGVDLVVAVMGVLKAGAtfsVIDPAYPPARQ---TIYLSVAKPRALI-- 347
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 131 aalegevvreviaSIEAEGNAAPRVFT---------TRARALQTRDDPRVFGTQREAsgageGARDLLQAAQAVQpgRKP 201
Cdd:TIGR03443 348 -------------VIEKAGTLDQLVRDyidkelelrTEIPALALQDDGSLVGGSLEG-----GETDVLAPYQALK--DTP 407
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 202 PPVVLAASDPAMLVYTSGTSGRPKGAICTHGNFA--FN--SQTYrdfcGLREGGP---ILGVA----------PLFHITG 264
Cdd:TIGR03443 408 TGVVVGPDSNPTLSFTSGSEGIPKGVLGRHFSLAyyFPwmAKRF----GLSENDKftmLSGIAhdpiqrdmftPLFLGAQ 483
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 265 L-------VGHIG--AAWIARAPLILTHrFDPAAtldaieehrAEFTIGAITVFIALLHHA----------DATRekLAT 325
Cdd:TIGR03443 484 LlvptaddIGTPGrlAEWMAKYGATVTH-LTPAM---------GQLLSAQATTPIPSLHHAffvgdiltkrDCLR--LQT 551
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 326 LtkiysggapiAPSVveafrakfghVIHGAYGLTETNsptHMVPLARTAPVDPHSGALAMGVPVPGAEAAIVD------- 398
Cdd:TIGR03443 552 L----------AENV----------CIVNMYGTTETQ---RAVSYFEIPSRSSDSTFLKNLKDVMPAGKGMKNvqllvvn 608
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 399 --DDGNMLAAGETGEIVCRGPMVVPGYWNNAAATADAFRGGWF-----------------------------HTGDVGfm 447
Cdd:TIGR03443 609 rnDRTQTCGVGEVGEIYVRAGGLAEGYLGLPELNAEKFVNNWFvdpshwidldkennkperefwlgprdrlyRTGDLG-- 686
|
490 500 510 520
....*....|....*....|....*....|....*....|....*..
gi 1595048490 448 deagwFYLVD-------RKKDMINAAGYKVWPREVEDVLYGHPAVRE 487
Cdd:TIGR03443 687 -----RYLPDgnveccgRADDQVKIRGFRIELGEIDTHLSQHPLVRE 728
|
|
| PRK12582 |
PRK12582 |
acyl-CoA synthetase; Provisional |
62-449 |
3.02e-08 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 237144 [Multi-domain] Cd Length: 624 Bit Score: 56.59 E-value: 3.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 62 DRIACLLLDEGVQRGDRVALYLQNVPQFVMALLGIWKAGAVMVPVNPM-----NRARELKLLLDDSQARVLICDaalege 136
Cdd:PRK12582 91 DALAQALLDLGLDPGRPVMILSGNSIEHALMTLAAMQAGVPAAPVSPAyslmsHDHAKLKHLFDLVKPRVVFAQ------ 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 137 vvreviasieaegNAAPrvfTTRARALQTRDDPRVFgtqrEASGAGEGARDLLQAAQAVQPgrkPPPVVLAASDP----- 211
Cdd:PRK12582 165 -------------SGAP---FARALAALDLLDVTVV----HVTGPGEGIASIAFADLAATP---PTAAVAAAIAAitpdt 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 212 -AMLVYTSGTSGRPKGAICTHGNFAFNSQTYRdfcGLREGGPILGVA------PLFHITGlvGHI---------GAAWI- 274
Cdd:PRK12582 222 vAKYLFTSGSTGMPKAVINTQRMMCANIAMQE---QLRPREPDPPPPvsldwmPWNHTMG--GNAnfngllwggGTLYId 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 275 ARAPLilTHRFDPaaTLDAIEEhRAEFTIGAITVFIALLHHA----DATREKL-ATLTKIYSGGAPIAPSVVE-----AF 344
Cdd:PRK12582 297 DGKPL--PGMFEE--TIRNLRE-ISPTVYGNVPAGYAMLAEAmekdDALRRSFfKNLRLMAYGGATLSDDLYErmqalAV 371
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 345 RAKfGH--VIHGAYGLTETNspthmvPLARTAPVDPHSGALAmGVPVPGAEAaivdddgNMLAAGETGEIVCRGPMVVPG 422
Cdd:PRK12582 372 RTT-GHriPFYTGYGATETA------PTTTGTHWDTERVGLI-GLPLPGVEL-------KLAPVGDKYEVRVKGPNVTPG 436
|
410 420
....*....|....*....|....*....
gi 1595048490 423 YWNNAAATADAF-RGGWFHTGDVG-FMDE 449
Cdd:PRK12582 437 YHKDPELTAAAFdEEGFYRLGDAArFVDP 465
|
|
| PLN03052 |
PLN03052 |
acetate--CoA ligase; Provisional |
442-556 |
7.96e-06 |
|
acetate--CoA ligase; Provisional
Pssm-ID: 215553 [Multi-domain] Cd Length: 728 Bit Score: 48.92 E-value: 7.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 442 GDVgFMDEAGWFYLVD-RKKDMINAAGYKVWPREVEDVL-YGHPAVREAAVVGVPDPYRGE---TVKAVVSLRAGAVADA 516
Cdd:PLN03052 594 GDI-FERTSGGYYRAHgRADDTMNLGGIKVSSVEIERVCnAADESVLETAAIGVPPPGGGPeqlVIAAVLKDPPGSNPDL 672
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 1595048490 517 AEL-IAFCKARMAA----YKYPRIVEFrDELPKTATGKILRRELR 556
Cdd:PLN03052 673 NELkKIFNSAIQKKlnplFKVSAVVIV-PSFPRTASNKVMRRVLR 716
|
|
| PaaK |
COG1541 |
Phenylacetate-coenzyme A ligase PaaK, adenylate-forming domain family [Coenzyme transport and ... |
52-129 |
8.37e-03 |
|
Phenylacetate-coenzyme A ligase PaaK, adenylate-forming domain family [Coenzyme transport and metabolism];
Pssm-ID: 441150 [Multi-domain] Cd Length: 423 Bit Score: 38.59 E-value: 8.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1595048490 52 LDWQALDAWSDRIACLLLDEGVQRGDRValylQNV------PQFVMALLGIWKAGAVMVPVNPMNRARELKLLLDDsQAR 125
Cdd:COG1541 103 YTRKDLDRWAELFARSLRAAGVRPGDRV----QNAfgyglfTGGLGLHYGAERLGATVIPAGGGNTERQLRLMQDF-GPT 177
|
....
gi 1595048490 126 VLIC 129
Cdd:COG1541 178 VLVG 181
|
|
| |
