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Conserved domains on  [gi|1424095424|ref|WP_112391116|]
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alpha/beta hydrolase [Agrobacterium tumefaciens]

Protein Classification

alpha/beta hydrolase( domain architecture ID 11437497)

alpha/beta hydrolase catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

CATH:  3.40.50.1820
EC:  3.-.-.-
Gene Ontology:  GO:0016787
PubMed:  19508187|12369917|37582413

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 42-351 3.75e-95

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


:

Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 283.34  E-value: 3.75e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424095424  42 VFPKSEKVDHEKVSFKNRYGIILAADLYMPKTRNSvGNPAIVVSGPFGAVKEQSSgLYAQTMAERGFVTLAFDPSYTGES 121
Cdd:COG1073     1 IFPPSDKVNKEDVTFKSRDGIKLAGDLYLPAGASK-KYPAVVVAHGNGGVKEQRA-LYAQRLAELGFNVLAFDYRGYGES 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424095424 122 GGEPRNIASPDINteDFSAAVDYIGLRPEVDRERIGVIGVCGWGGMALNAVASDKRVKAVVASTMYDmtrvmskgyndsv 201
Cdd:COG1073    79 EGEPREEGSPERR--DARAAVDYLRTLPGVDPERIGLLGISLGGGYALNAAATDPRVKAVILDSPFT------------- 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424095424 202 tleqrtaTLEQLSRQRWVDAEKGIpayqaaynaevGPDAPqfmvdyhdyystprgYHKRAvnsrnawsqtTPISFMN--M 279
Cdd:COG1073   144 -------SLEDLAAQRAKEARGAY-----------LPGVP---------------YLPNV----------RLASLLNdeF 180

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1424095424 280 PILSYIAEISpRPVLFIHGEK--AHSLYFAETAYAAAAEPKELHVIPGASHTDLYDKMDVIPFTKLASFFEQHL 351
Cdd:COG1073   181 DPLAKIEKIS-RPLLFIHGEKdeAVPFYMSEDLYEAAAEPKELLIVPGAGHVDLYDRPEEEYFDKLAEFFKKNL 253
 
Name Accession Description Interval E-value
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 42-351 3.75e-95

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 283.34  E-value: 3.75e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424095424  42 VFPKSEKVDHEKVSFKNRYGIILAADLYMPKTRNSvGNPAIVVSGPFGAVKEQSSgLYAQTMAERGFVTLAFDPSYTGES 121
Cdd:COG1073     1 IFPPSDKVNKEDVTFKSRDGIKLAGDLYLPAGASK-KYPAVVVAHGNGGVKEQRA-LYAQRLAELGFNVLAFDYRGYGES 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424095424 122 GGEPRNIASPDINteDFSAAVDYIGLRPEVDRERIGVIGVCGWGGMALNAVASDKRVKAVVASTMYDmtrvmskgyndsv 201
Cdd:COG1073    79 EGEPREEGSPERR--DARAAVDYLRTLPGVDPERIGLLGISLGGGYALNAAATDPRVKAVILDSPFT------------- 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424095424 202 tleqrtaTLEQLSRQRWVDAEKGIpayqaaynaevGPDAPqfmvdyhdyystprgYHKRAvnsrnawsqtTPISFMN--M 279
Cdd:COG1073   144 -------SLEDLAAQRAKEARGAY-----------LPGVP---------------YLPNV----------RLASLLNdeF 180

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1424095424 280 PILSYIAEISpRPVLFIHGEK--AHSLYFAETAYAAAAEPKELHVIPGASHTDLYDKMDVIPFTKLASFFEQHL 351
Cdd:COG1073   181 DPLAKIEKIS-RPLLFIHGEKdeAVPFYMSEDLYEAAAEPKELLIVPGAGHVDLYDRPEEEYFDKLAEFFKKNL 253
Peptidase_S15 pfam02129
X-Pro dipeptidyl-peptidase (S15 family);
61-298 1.41e-07

X-Pro dipeptidyl-peptidase (S15 family);


Pssm-ID: 396621 [Multi-domain]  Cd Length: 264  Bit Score: 51.96  E-value: 1.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424095424  61 GIILAADLYMPkTRNSVGNPAIVVSGPFGAVKEQSSGLY----AQTMAERGFVTLAFDPSYTGESGGEpRNIASPDiNTE 136
Cdd:pfam02129   2 GVRLAADIYRP-TKTGGPVPALLTRSPYGARRDGASDLAlahpEWEFAARGYAVVYQDVRGTGGSEGV-FTVGGPQ-EAA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424095424 137 DFSAAVDYIGLRPEVDReRIGVIGvCGWGGMALNAVASD--KRVKAVVA-STMYDMTRVMSKG----YNDSVTLEQRTAT 209
Cdd:pfam02129  79 DGKDVIDWLAGQPWCNG-KVGMTG-ISYLGTTQLAAAATgpPGLKAIAPeSGISDLYDYYREGgavrAPGGLGWEDLDLL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424095424 210 LEQLSRQRW--VDAEKGIPAYQAAYNAEVGPDAPQFMV--------DYHDYystprgYHKRAVNSRNAWSQTtpisfmnm 279
Cdd:pfam02129 157 AEALTSRRAddGDAYRAAARYEAAGDELLAELDRQLFLlewllqtgDYDAF------WQDRNYLEDADKVKA-------- 222

                         250
                  ....*....|....*....
gi 1424095424 280 pilsyiaeisprPVLFIHG 298
Cdd:pfam02129 223 ------------PVLLVGG 229
 
Name Accession Description Interval E-value
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 42-351 3.75e-95

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 283.34  E-value: 3.75e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424095424  42 VFPKSEKVDHEKVSFKNRYGIILAADLYMPKTRNSvGNPAIVVSGPFGAVKEQSSgLYAQTMAERGFVTLAFDPSYTGES 121
Cdd:COG1073     1 IFPPSDKVNKEDVTFKSRDGIKLAGDLYLPAGASK-KYPAVVVAHGNGGVKEQRA-LYAQRLAELGFNVLAFDYRGYGES 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424095424 122 GGEPRNIASPDINteDFSAAVDYIGLRPEVDRERIGVIGVCGWGGMALNAVASDKRVKAVVASTMYDmtrvmskgyndsv 201
Cdd:COG1073    79 EGEPREEGSPERR--DARAAVDYLRTLPGVDPERIGLLGISLGGGYALNAAATDPRVKAVILDSPFT------------- 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424095424 202 tleqrtaTLEQLSRQRWVDAEKGIpayqaaynaevGPDAPqfmvdyhdyystprgYHKRAvnsrnawsqtTPISFMN--M 279
Cdd:COG1073   144 -------SLEDLAAQRAKEARGAY-----------LPGVP---------------YLPNV----------RLASLLNdeF 180

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1424095424 280 PILSYIAEISpRPVLFIHGEK--AHSLYFAETAYAAAAEPKELHVIPGASHTDLYDKMDVIPFTKLASFFEQHL 351
Cdd:COG1073   181 DPLAKIEKIS-RPLLFIHGEKdeAVPFYMSEDLYEAAAEPKELLIVPGAGHVDLYDRPEEEYFDKLAEFFKKNL 253
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
55-351 6.01e-24

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 98.17  E-value: 6.01e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424095424  55 SFKNRYGIILAADLYMPKTRNSVgnPAIVVSGPFGAVKEQSSGLYAQTMAERGFVTLAFDPSYTGESGGEPRniaspDIN 134
Cdd:COG1506     1 TFKSADGTTLPGWLYLPADGKKY--PVVVYVHGGPGSRDDSFLPLAQALASRGYAVLAPDYRGYGESAGDWG-----GDE 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424095424 135 TEDFSAAVDYIGLRPEVDRERIGVIGVCGWGGMALNAVA-SDKRVKAVVAstmydmtrvmskgyndsvtleqrtatleql 213
Cdd:COG1506    74 VDDVLAAIDYLAARPYVDPDRIGIYGHSYGGYMALLAAArHPDRFKAAVA------------------------------ 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424095424 214 srqrwvdaekgipayqaaynaevgpDAPqfMVDYHDYYSTPRGYHKRAVNsrnaWSQTTPISFMNMPILSYIAEIsPRPV 293
Cdd:COG1506   124 -------------------------LAG--VSDLRSYYGTTREYTERLMG----GPWEDPEAYAARSPLAYADKL-KTPL 171

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1424095424 294 LFIHGEK------AHSLYFaETAYAAAAEPKELHVIPGASHTdLYDKMDVIPFTKLASFFEQHL 351
Cdd:COG1506   172 LLIHGEAddrvppEQAERL-YEALKKAGKPVELLVYPGEGHG-FSGAGAPDYLERILDFLDRHL 233
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
49-183 2.66e-16

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 76.93  E-value: 2.66e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424095424  49 VDHEKVSFKNRYGIILAADLYMPKTRNSVgnPAIVV----SGPFGAVKEqssglYAQTMAERGFVTLAFD------PSYT 118
Cdd:COG0412     1 MTTETVTIPTPDGVTLPGYLARPAGGGPR--PGVVVlheiFGLNPHIRD-----VARRLAAAGYVVLAPDlygrggPGDD 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1424095424 119 GESGGEPRNIASPDINTEDFSAAVDYIGLRPEVDRERIGVIGVCgWGG-MALNAVASDKRVKAVVA 183
Cdd:COG0412    74 PDEARALMGALDPELLAADLRAALDWLKAQPEVDAGRVGVVGFC-FGGgLALLAAARGPDLAAAVS 138
Peptidase_S15 pfam02129
X-Pro dipeptidyl-peptidase (S15 family);
61-298 1.41e-07

X-Pro dipeptidyl-peptidase (S15 family);


Pssm-ID: 396621 [Multi-domain]  Cd Length: 264  Bit Score: 51.96  E-value: 1.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424095424  61 GIILAADLYMPkTRNSVGNPAIVVSGPFGAVKEQSSGLY----AQTMAERGFVTLAFDPSYTGESGGEpRNIASPDiNTE 136
Cdd:pfam02129   2 GVRLAADIYRP-TKTGGPVPALLTRSPYGARRDGASDLAlahpEWEFAARGYAVVYQDVRGTGGSEGV-FTVGGPQ-EAA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424095424 137 DFSAAVDYIGLRPEVDReRIGVIGvCGWGGMALNAVASD--KRVKAVVA-STMYDMTRVMSKG----YNDSVTLEQRTAT 209
Cdd:pfam02129  79 DGKDVIDWLAGQPWCNG-KVGMTG-ISYLGTTQLAAAATgpPGLKAIAPeSGISDLYDYYREGgavrAPGGLGWEDLDLL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424095424 210 LEQLSRQRW--VDAEKGIPAYQAAYNAEVGPDAPQFMV--------DYHDYystprgYHKRAVNSRNAWSQTtpisfmnm 279
Cdd:pfam02129 157 AEALTSRRAddGDAYRAAARYEAAGDELLAELDRQLFLlewllqtgDYDAF------WQDRNYLEDADKVKA-------- 222

                         250
                  ....*....|....*....
gi 1424095424 280 pilsyiaeisprPVLFIHG 298
Cdd:pfam02129 223 ------------PVLLVGG 229
DLH pfam01738
Dienelactone hydrolase family;
65-183 3.01e-07

Dienelactone hydrolase family;


Pssm-ID: 396343 [Multi-domain]  Cd Length: 213  Bit Score: 50.43  E-value: 3.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424095424  65 AADLYMPKtrnSVGNPAIVVSGPFGAVKEQSSgLYAQTMAERGFVTLAFDPSYTGESGGEPRNIA----------SPDIN 134
Cdd:pfam01738   1 DAYLATPK---NPPWPVVVVFQEIFGVNDNIR-EIADRLADEGYVALAPDLYFRQGDPNDEADAAramfelvskrVMEKV 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1424095424 135 TEDFSAAVDYIGLRPEVDRERIGVIGVCGWGGMALNAVASDKRVKAVVA 183
Cdd:pfam01738  77 LDDLEAAVNYLKSQPEVSPKKVGVVGYCMGGALAVLLAAKGPLVDAAVG 125
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
51-184 3.73e-07

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 50.39  E-value: 3.73e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424095424  51 HEKVSFKNRYGIILAADLYMPKTRNSvgnPAIVVSGPFGAvkeqSSGLY---AQTMAERGFVTLAFDPSYTGESGGEPRN 127
Cdd:COG2267     3 RRLVTLPTRDGLRLRGRRWRPAGSPR---GTVVLVHGLGE----HSGRYaelAEALAAAGYAVLAFDLRGHGRSDGPRGH 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1424095424 128 IASPDINTEDFSAAVDYIGLRPEvdrERIGVIGvCGWGGM-ALNAVAS-DKRVKAVVAS 184
Cdd:COG2267    76 VDSFDDYVDDLRAALDALRARPG---LPVVLLG-HSMGGLiALLYAARyPDRVAGLVLL 130
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
100-194 6.65e-06

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 46.45  E-value: 6.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424095424 100 AQTMAERGFVTLAFDPSYTGESGGEPRNIASPDINT---EDFSAAVDYIGLRPEVDRERIGVIgvcGW--GGMALNAVAS 174
Cdd:pfam00326   7 AQLLADRGYVVAIANGRGSGGYGEAFHDAGKGDLGQnefDDFIAAAEYLIEQGYTDPDRLAIW---GGsyGGYLTGAALN 83

                          90       100
                  ....*....|....*....|...
gi 1424095424 175 D--KRVKAVVAST-MYDMTRVMS 194
Cdd:pfam00326  84 QrpDLFKAAVAHVpVVDWLAYMS 106
COG4188 COG4188
Predicted dienelactone hydrolase [General function prediction only];
64-183 5.30e-05

Predicted dienelactone hydrolase [General function prediction only];


Pssm-ID: 443342 [Multi-domain]  Cd Length: 326  Bit Score: 44.71  E-value: 5.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424095424  64 LAADLYMPKTRNSVGN-----PAIVVSGPFGAVKEQSSGLyAQTMAERGFVTLAFD---PSYTGESGGEPRNIASPDIN- 134
Cdd:COG4188    42 LPVDVWYPATAPADAPaggpfPLVVLSHGLGGSREGYAYL-AEHLASHGYVVAAPDhpgSNAADLSAALDGLADALDPEe 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1424095424 135 ----TEDFSAAVDYI--------GLRPEVDRERIGVIG-------------------------------VCGWGGMA-LN 170
Cdd:COG4188   121 lwerPLDLSFVLDQLlalnksdpPLAGRLDLDRIGVIGhslggytalalagarldfaalrqycgknpdlQCRALDLPrLA 200

                         170
                  ....*....|...
gi 1424095424 171 AVASDKRVKAVVA 183
Cdd:COG4188   201 YDLRDPRIKAVVA 213
Axe1 COG3458
Cephalosporin-C deacetylase or related acetyl esterase [Secondary metabolites biosynthesis, ...
 141-192 8.13e-05

Cephalosporin-C deacetylase or related acetyl esterase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442681 [Multi-domain]  Cd Length: 318  Bit Score: 44.03  E-value: 8.13e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1424095424 141 AVDYIGLRPEVDRERIGVIGVCGWGGMALNAVASDKRVKAVVAS--TMYDMTRV 192
Cdd:COG3458   163 AVDALRSLPEVDGKRIGVTGGSQGGGLALAAAALDPRVKAAAADvpFLCDFRRA 216
AXE1 pfam05448
Acetyl xylan esterase (AXE1); This family consists of several bacterial acetyl xylan esterase ...
 137-183 3.51e-03

Acetyl xylan esterase (AXE1); This family consists of several bacterial acetyl xylan esterase proteins. Acetyl xylan esterases are enzymes that hydrolyse the ester linkages of the acetyl groups in position 2 and/or 3 of the xylose moieties of natural acetylated xylan from hardwood. These enzymes are one of the accessory enzymes which are part of the xylanolytic system, together with xylanases, beta-xylosidases, alpha-arabinofuranosidases and methylglucuronidases; these are all required for the complete hydrolysis of xylan.


Pssm-ID: 398876 [Multi-domain]  Cd Length: 316  Bit Score: 38.92  E-value: 3.51e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1424095424 137 DFSAAVDYIGLRPEVDRERIGVIGVCGWGGMALNAVASDKRVKAVVA 183
Cdd:pfam05448 157 DAVRAVEIVMSFPEVDEERIVVTGGSQGGALALAAAALSPRIKAVVA 203
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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