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Conserved domains on  [gi|1421773513|ref|WP_111877239|]
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ISC system 2Fe-2S type ferredoxin [Paracidovorax anthurii]

Protein Classification

2Fe-2S iron-sulfur cluster-binding family protein( domain architecture ID 1376)

2Fe-2S iron-sulfur cluster-binding family protein such as ferredoxin, an iron-sulfur protein transfering electrons in a wide variety of metabolic reactions

Gene Ontology:  GO:0051536

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
fer2 super family cl00159
2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in ...
 2-111 1.98e-45

2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis and ferredoxins, which participate in redox chains (from bacteria to mammals). Fold is ismilar to thioredoxin.


The actual alignment was detected with superfamily member TIGR02007:

Pssm-ID: 444718 [Multi-domain]  Cd Length: 110  Bit Score: 142.62  E-value: 1.98e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1421773513   2 PVIKILPHPEYCPAGTEVTVPVGTSICEALLDNGIKIEHACDMSCACTTCHVIVRKGYESLNEAEEEEEDLLDRAWGLEP 81
Cdd:TIGR02007   1 PKIVFLPHEDLCPEGAVVEAKPGETILDVALDNGIEIEHACEKSCACTTCHCIVREGFDSLEEASEQEEDMLDKAWGLEP 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1421773513  82 QSRLSCQAILAQSDVTVEIPKYTINHAKEN 111
Cdd:TIGR02007  81 DSRLSCQAVVADEDLVVEIPKYTINHAREA 110
 
Name Accession Description Interval E-value
fdx_isc TIGR02007
ferredoxin, 2Fe-2S type, ISC system; This family consists of proteobacterial ferredoxins ...
 2-111 1.98e-45

ferredoxin, 2Fe-2S type, ISC system; This family consists of proteobacterial ferredoxins associated with and essential to the ISC system of 2Fe-2S cluster assembly. This family is closely related to (but excludes) eukaryotic (mitochondrial) adrenodoxins, which are ferredoxins involved in electron transfer to P450 cytochromes. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 131062 [Multi-domain]  Cd Length: 110  Bit Score: 142.62  E-value: 1.98e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1421773513   2 PVIKILPHPEYCPAGTEVTVPVGTSICEALLDNGIKIEHACDMSCACTTCHVIVRKGYESLNEAEEEEEDLLDRAWGLEP 81
Cdd:TIGR02007   1 PKIVFLPHEDLCPEGAVVEAKPGETILDVALDNGIEIEHACEKSCACTTCHCIVREGFDSLEEASEQEEDMLDKAWGLEP 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1421773513  82 QSRLSCQAILAQSDVTVEIPKYTINHAKEN 111
Cdd:TIGR02007  81 DSRLSCQAVVADEDLVVEIPKYTINHAREA 110
Fdx COG0633
Ferredoxin [Energy production and conversion];
1-101 1.67e-19

Ferredoxin [Energy production and conversion];


Pssm-ID: 440398 [Multi-domain]  Cd Length: 87  Bit Score: 76.04  E-value: 1.67e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1421773513   1 MPVIKILPHpeycpaGTEVTVPVGTSICEALLDNGIKIEHACDMsCACTTCHVIVRKGYESLNEAEEEeedlldRAWGLE 80
Cdd:COG0633     1 MPKVTFIPE------GHTVEVPAGESLLEAALRAGIDLPYSCRS-GACGTCHVRVLEGEVDHREEDAL------SDEERA 67

                          90       100
                  ....*....|....*....|.
gi 1421773513  81 PQSRLSCQAIlAQSDVTVEIP 101
Cdd:COG0633    68 AGSRLACQAR-PTSDLVVELP 87
PLN02593 PLN02593
adrenodoxin-like ferredoxin protein
 14-112 1.26e-16

adrenodoxin-like ferredoxin protein


Pssm-ID: 178203 [Multi-domain]  Cd Length: 117  Bit Score: 69.36  E-value: 1.26e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1421773513  14 PAGTE--VTVPVGTSICEALLDNGIKIEHACDMSCACTTCHVIV--RKGYESLNEAEEEEEDLLDRAWGLEPQSRLSCQA 89
Cdd:PLN02593    8 KDGEErtVKAPVGMSLLEAAHENDIELEGACEGSLACSTCHVIVmdEKVYNKLPEPTDEENDMLDLAFGLTETSRLGCQV 87

                          90       100
                  ....*....|....*....|....*
gi 1421773513  90 ILAQS--DVTVEIPKYTINHAKENH 112
Cdd:PLN02593   88 IAKPEldGMRLALPAATRNFAVDGH 112
fer2 cd00207
2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in ...
 16-99 6.21e-12

2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis and ferredoxins, which participate in redox chains (from bacteria to mammals). Fold is ismilar to thioredoxin.


Pssm-ID: 238126 [Multi-domain]  Cd Length: 84  Bit Score: 56.63  E-value: 6.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1421773513  16 GTEVTVPVGTSICEALLDNGIKIEHACDMScACTTCHVIVRKGyeslneAEEEEEDLLDRAWGLEPQSRLSCQAiLAQSD 95
Cdd:cd00207     9 GVEVEVPEGETLLDAAREAGIDIPYSCRAG-ACGTCKVEVVEG------EVDQSDPSLLDEEEAEGGYVLACQT-RVTDG 80


                  ....
gi 1421773513  96 VTVE 99
Cdd:cd00207    81 LVIE 84
Fer2 pfam00111
2Fe-2S iron-sulfur cluster binding domain;
14-91 2.29e-04

2Fe-2S iron-sulfur cluster binding domain;


Pssm-ID: 395061 [Multi-domain]  Cd Length: 77  Bit Score: 36.73  E-value: 2.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1421773513  14 PAGTEVTVPV---GTSICEALLDNGIKIEHACDMSCaCTTCHVIVRKGyeslneAEEEEEDLLDRAWGLEPQSRLSCQAI 90
Cdd:pfam00111   3 INGKGVTIEVpdgETTLLDAAEEAGIDIPYSCRGGG-CGTCAVKVLEG------EDQSDQSFLEDDELAAGYVVLACQTY 75


                  .
gi 1421773513  91 L 91
Cdd:pfam00111  76 P 76
 
Name Accession Description Interval E-value
fdx_isc TIGR02007
ferredoxin, 2Fe-2S type, ISC system; This family consists of proteobacterial ferredoxins ...
 2-111 1.98e-45

ferredoxin, 2Fe-2S type, ISC system; This family consists of proteobacterial ferredoxins associated with and essential to the ISC system of 2Fe-2S cluster assembly. This family is closely related to (but excludes) eukaryotic (mitochondrial) adrenodoxins, which are ferredoxins involved in electron transfer to P450 cytochromes. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 131062 [Multi-domain]  Cd Length: 110  Bit Score: 142.62  E-value: 1.98e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1421773513   2 PVIKILPHPEYCPAGTEVTVPVGTSICEALLDNGIKIEHACDMSCACTTCHVIVRKGYESLNEAEEEEEDLLDRAWGLEP 81
Cdd:TIGR02007   1 PKIVFLPHEDLCPEGAVVEAKPGETILDVALDNGIEIEHACEKSCACTTCHCIVREGFDSLEEASEQEEDMLDKAWGLEP 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1421773513  82 QSRLSCQAILAQSDVTVEIPKYTINHAKEN 111
Cdd:TIGR02007  81 DSRLSCQAVVADEDLVVEIPKYTINHAREA 110
Fdx COG0633
Ferredoxin [Energy production and conversion];
1-101 1.67e-19

Ferredoxin [Energy production and conversion];


Pssm-ID: 440398 [Multi-domain]  Cd Length: 87  Bit Score: 76.04  E-value: 1.67e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1421773513   1 MPVIKILPHpeycpaGTEVTVPVGTSICEALLDNGIKIEHACDMsCACTTCHVIVRKGYESLNEAEEEeedlldRAWGLE 80
Cdd:COG0633     1 MPKVTFIPE------GHTVEVPAGESLLEAALRAGIDLPYSCRS-GACGTCHVRVLEGEVDHREEDAL------SDEERA 67

                          90       100
                  ....*....|....*....|.
gi 1421773513  81 PQSRLSCQAIlAQSDVTVEIP 101
Cdd:COG0633    68 AGSRLACQAR-PTSDLVVELP 87
PLN02593 PLN02593
adrenodoxin-like ferredoxin protein
 14-112 1.26e-16

adrenodoxin-like ferredoxin protein


Pssm-ID: 178203 [Multi-domain]  Cd Length: 117  Bit Score: 69.36  E-value: 1.26e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1421773513  14 PAGTE--VTVPVGTSICEALLDNGIKIEHACDMSCACTTCHVIV--RKGYESLNEAEEEEEDLLDRAWGLEPQSRLSCQA 89
Cdd:PLN02593    8 KDGEErtVKAPVGMSLLEAAHENDIELEGACEGSLACSTCHVIVmdEKVYNKLPEPTDEENDMLDLAFGLTETSRLGCQV 87

                          90       100
                  ....*....|....*....|....*
gi 1421773513  90 ILAQS--DVTVEIPKYTINHAKENH 112
Cdd:PLN02593   88 IAKPEldGMRLALPAATRNFAVDGH 112
fer2 cd00207
2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in ...
 16-99 6.21e-12

2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis and ferredoxins, which participate in redox chains (from bacteria to mammals). Fold is ismilar to thioredoxin.


Pssm-ID: 238126 [Multi-domain]  Cd Length: 84  Bit Score: 56.63  E-value: 6.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1421773513  16 GTEVTVPVGTSICEALLDNGIKIEHACDMScACTTCHVIVRKGyeslneAEEEEEDLLDRAWGLEPQSRLSCQAiLAQSD 95
Cdd:cd00207     9 GVEVEVPEGETLLDAAREAGIDIPYSCRAG-ACGTCKVEVVEG------EVDQSDPSLLDEEEAEGGYVLACQT-RVTDG 80


                  ....
gi 1421773513  96 VTVE 99
Cdd:cd00207    81 LVIE 84
COG3894 COG3894
Uncharacterized 2Fe-2S and 4Fe-4S clusters-containing protein, contains DUF4445 domain ...
 1-110 1.51e-10

Uncharacterized 2Fe-2S and 4Fe-4S clusters-containing protein, contains DUF4445 domain [Function unknown];


Pssm-ID: 443101 [Multi-domain]  Cd Length: 621  Bit Score: 56.35  E-value: 1.51e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1421773513   1 MPVIKILPHPEycpaGTEVTVPVGTSICEALLDNGIKIEHACDMSCACTTCHVIVRKGYESLNEAEEEEEDLLDrawGLE 80
Cdd:COG3894     1 MPKVKVTFLPS----GKRVEVEAGTTLLDAAREAGVDIDAPCGGRGTCGKCKVKVEEGEFSPVTEEERRLLSPE---ELA 73

                          90       100       110
                  ....*....|....*....|....*....|
gi 1421773513  81 PQSRLSCQAILaQSDVTVEIPKYTINHAKE 110
Cdd:COG3894    74 EGYRLACQARV-LGDLVVEVPPESRLDKQK 102
NqrF COG2871
Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF [Energy production and ...
 14-101 2.19e-08

Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF [Energy production and conversion]; Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF is part of the Pathway/BioSystem: Na+-translocating NADH dehydrogenase


Pssm-ID: 442118 [Multi-domain]  Cd Length: 396  Bit Score: 50.25  E-value: 2.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1421773513  14 PAGTEVTVPVGTSICEALLDNGIKIEHACDMSCACTTCHVIVRKGYESLNEAEEEEEDLLDRAWGLepqsRLSCQAILaQ 93
Cdd:COG2871    41 GDGKEIEVEEGQTLLDALLRQGIFLPSACGGGGTCGQCKVKVLEGGGDILPTETFHLSDRERKEGY----RLACQVKV-K 115


                  ....*...
gi 1421773513  94 SDVTVEIP 101
Cdd:COG2871   116 SDMEIEVP 123
PTZ00490 PTZ00490
Ferredoxin superfamily; Provisional
 18-106 4.23e-08

Ferredoxin superfamily; Provisional


Pssm-ID: 185668  Cd Length: 143  Bit Score: 47.94  E-value: 4.23e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1421773513  18 EVTVPVGTSICEALLD-NGIKIEHACDMSCACTTCHVIVRKG-YESLNEAEEEEEDLLDRAWGLEPQSRLSCQAIL--AQ 93
Cdd:PTZ00490   49 DVEVPVGMSLMHALRDvAKLDVEGTCNGCMQCATCHVYLSAAsFKKLGGPSEEEEDVLAKALDVKETSRLACQVDLtpEM 128

                          90
                  ....*....|...
gi 1421773513  94 SDVTVEIPKYTIN 106
Cdd:PTZ00490  129 DGLEVELPSYVTN 141
Fer2 pfam00111
2Fe-2S iron-sulfur cluster binding domain;
14-91 2.29e-04

2Fe-2S iron-sulfur cluster binding domain;


Pssm-ID: 395061 [Multi-domain]  Cd Length: 77  Bit Score: 36.73  E-value: 2.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1421773513  14 PAGTEVTVPV---GTSICEALLDNGIKIEHACDMSCaCTTCHVIVRKGyeslneAEEEEEDLLDRAWGLEPQSRLSCQAI 90
Cdd:pfam00111   3 INGKGVTIEVpdgETTLLDAAEEAGIDIPYSCRGGG-CGTCAVKVLEG------EDQSDQSFLEDDELAAGYVVLACQTY 75


                  .
gi 1421773513  91 L 91
Cdd:pfam00111  76 P 76
PRK07609 PRK07609
CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated
 14-104 2.02e-03

CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated


Pssm-ID: 181058 [Multi-domain]  Cd Length: 339  Bit Score: 36.00  E-value: 2.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1421773513  14 PAGTEVTVPVGTSICEALLDNGIKIEHACDmSCACTTCHVIVRKGYESLNEAEEEEEDLLDRAWGLEpqsrLSCQAIlAQ 93
Cdd:PRK07609    9 PSGRQFTAEPDETILDAALRQGIHLPYGCK-NGACGSCKGRLLEGEVEQGPHQASALSGEERAAGEA----LTCCAK-PL 82

                          90
                  ....*....|.
gi 1421773513  94 SDVTVEIPKYT 104
Cdd:PRK07609   83 SDLVLEAREVP 93
Fer2_4 pfam13510
2Fe-2S iron-sulfur cluster binding domain; The 2Fe-2S ferredoxin family have a general core ...
 16-55 8.63e-03

2Fe-2S iron-sulfur cluster binding domain; The 2Fe-2S ferredoxin family have a general core structure consisting of beta(2)-alpha-beta(2) which a beta-grasp type fold. The domain is around one hundred amino acids with four conserved cysteine residues to which the 2Fe-2S cluster is ligated. This cluster appears within sarcosine oxidase proteins.


Pssm-ID: 433268 [Multi-domain]  Cd Length: 82  Bit Score: 32.90  E-value: 8.63e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1421773513  16 GTEVTVPVGTSICEALLDNGIKIEHAC------DMSCA---CTTCHVIV 55
Cdd:pfam13510  10 GRPVTAPEGDTIAAALLANGVRVPRSCkygrprGIFCAmgeCRNCLVEV 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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