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Conserved domains on  [gi|1382177982|ref|WP_108045133|]
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Fur family transcriptional regulator Irr [Bosea sp. 124]

Protein Classification

Fur family transcriptional regulator( domain architecture ID 10002362)

Fur (ferric uptake regulator) family transcriptional regulator such as metal ion uptake regulator proteins, which are responsible for controlling the intracellular concentration of iron in many bacteria; similar to peroxide-responsive repressor PerR, zinc-uptake regulator Zur, nickel-uptake regulator Nur, manganese-uptake regulator Mur and iron response regulator Irr

Gene Ontology:  GO:0003700|GO:0006355
PubMed:  17216355

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fur COG0735
Fe2+ or Zn2+ uptake regulation protein Fur/Zur [Inorganic ion transport and metabolism];
22-148 1.95e-35

Fe2+ or Zn2+ uptake regulation protein Fur/Zur [Inorganic ion transport and metabolism];


:

Pssm-ID: 440498  Cd Length: 140  Bit Score: 120.06  E-value: 1.95e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382177982  22 HDIRERLRRVGLRPTRQRVSLGWVLFARgDRHISAEMLYEEAMKEKIPVSLATIYNTLHQFTQAGLLRELAIDGAKTFFD 101
Cdd:COG0735     5 EEAEELLREAGLRLTPQRLAILELLLES-DRHLSAEEIYEALRKKGPSISLATVYRTLDLLVEAGLVHRIEFGGGKARYE 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1382177982 102 TDSSE-HHHFVVDGENTVIDIPAEAVD-VAALPEPPEGYEIARVDVVVR 148
Cdd:COG0735    84 LNEGDhHHHLICTKCGKVIELDDDEIEeLLEELAEPHGFEIESHELEIY 132
 
Name Accession Description Interval E-value
Fur COG0735
Fe2+ or Zn2+ uptake regulation protein Fur/Zur [Inorganic ion transport and metabolism];
22-148 1.95e-35

Fe2+ or Zn2+ uptake regulation protein Fur/Zur [Inorganic ion transport and metabolism];


Pssm-ID: 440498  Cd Length: 140  Bit Score: 120.06  E-value: 1.95e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382177982  22 HDIRERLRRVGLRPTRQRVSLGWVLFARgDRHISAEMLYEEAMKEKIPVSLATIYNTLHQFTQAGLLRELAIDGAKTFFD 101
Cdd:COG0735     5 EEAEELLREAGLRLTPQRLAILELLLES-DRHLSAEEIYEALRKKGPSISLATVYRTLDLLVEAGLVHRIEFGGGKARYE 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1382177982 102 TDSSE-HHHFVVDGENTVIDIPAEAVD-VAALPEPPEGYEIARVDVVVR 148
Cdd:COG0735    84 LNEGDhHHHLICTKCGKVIELDDDEIEeLLEELAEPHGFEIESHELEIY 132
Fur_like cd07153
Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, ...
 37-148 1.34e-26

Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Ferric uptake regulator (Fur) and related metalloregulatory proteins are iron-dependent, DNA-binding repressors and activators mainly involved in iron metabolism. A general model for Fur repression under iron-rich conditions is that activated Fur (a dimer having one Fe2+ coordinated per monomer) binds to specific DNA sequences (Fur boxes) in the promoter region of iron-responsive genes, hindering access of RNA polymerase, and repressing transcription. Positive regulation by Fur can be direct or indirect, as in the Fur repression of an anti-sense regulatory small RNA. Some members sense metal ions other than Fe2+. For example, the zinc uptake regulator (Zur) responds to Zn2+, the manganese uptake regulator (Mur) responds to Mn2+, and the nickel uptake regulator (Nur) responds to Ni2+. Other members sense signals other than metal ions. For example, PerR, a metal-dependent sensor of hydrogen peroxide. PerR regulates DNA-binding activity through metal-based protein oxidation, and co-ordinates Mn2+ or Fe2+ at its regulatory site. Fur family proteins contain an N-terminal winged-helix DNA-binding domain followed by a dimerization domain; this CD spans both those domains.


Pssm-ID: 133478 [Multi-domain]  Cd Length: 116  Bit Score: 96.49  E-value: 1.34e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382177982  37 RQRVSLGWVLFARgDRHISAEMLYEEAMKEKIPVSLATIYNTLHQFTQAGLLRELAIDGAKTFFDTDSSEHHHFVVDGE- 115
Cdd:cd07153     1 PQRLAILEVLLES-DGHLTAEEIYERLRKKGPSISLATVYRTLELLEEAGLVREIELGDGKARYELNTDEHHHHLICTKc 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1382177982 116 NTVIDIPAEAVD-VAALPEPPEGYEIARVDVVVR 148
Cdd:cd07153    80 GKVIDFEDCPLEeLLEELAAKTGFKITSHRLELY 113
FUR pfam01475
Ferric uptake regulator family; This family includes metal ion uptake regulator proteins, that ...
 32-121 5.18e-19

Ferric uptake regulator family; This family includes metal ion uptake regulator proteins, that bind to the operator DNA and controls transcription of metal ion-responsive genes. This family is also known as the FUR family.


Pssm-ID: 426280  Cd Length: 121  Bit Score: 77.28  E-value: 5.18e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382177982  32 GLRPTRQRVSLGWVLFARGDRHISAEMLYEEAMKEKIPVSLATIYNTLHQFTQAGLLRELAIDGAKTFFDTDSSEHHHFV 111
Cdd:pfam01475   3 GLKLTPQRLKILEVLQKSDKEHLSAEEIYKELREEDPNISLATVYRTLNLLEEAGLVKRLEFDGGESRFELNTGHHHDHL 82

                          90
                  ....*....|.
gi 1382177982 112 VDGE-NTVIDI 121
Cdd:pfam01475  83 ICEDcGKVIEF 93
fur PRK09462
ferric uptake regulator; Provisional
 23-109 9.27e-10

ferric uptake regulator; Provisional


Pssm-ID: 236527  Cd Length: 148  Bit Score: 53.97  E-value: 9.27e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382177982  23 DIRERLRRVGLRPTRQRVSLGWVLFARGDRHISAEMLYEEAMKEKIPVSLATIYNTLHQFTQAGLLRELAIDGAKTFFDT 102
Cdd:PRK09462    3 DNNTALKKAGLKVTLPRLKILEVLQEPDNHHVSAEDLYKRLIDMGEEIGLATVYRVLNQFDDAGIVTRHNFEGGKSVFEL 82


                  ....*..
gi 1382177982 103 dSSEHHH 109
Cdd:PRK09462   83 -TQQHHH 88
 
Name Accession Description Interval E-value
Fur COG0735
Fe2+ or Zn2+ uptake regulation protein Fur/Zur [Inorganic ion transport and metabolism];
22-148 1.95e-35

Fe2+ or Zn2+ uptake regulation protein Fur/Zur [Inorganic ion transport and metabolism];


Pssm-ID: 440498  Cd Length: 140  Bit Score: 120.06  E-value: 1.95e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382177982  22 HDIRERLRRVGLRPTRQRVSLGWVLFARgDRHISAEMLYEEAMKEKIPVSLATIYNTLHQFTQAGLLRELAIDGAKTFFD 101
Cdd:COG0735     5 EEAEELLREAGLRLTPQRLAILELLLES-DRHLSAEEIYEALRKKGPSISLATVYRTLDLLVEAGLVHRIEFGGGKARYE 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1382177982 102 TDSSE-HHHFVVDGENTVIDIPAEAVD-VAALPEPPEGYEIARVDVVVR 148
Cdd:COG0735    84 LNEGDhHHHLICTKCGKVIELDDDEIEeLLEELAEPHGFEIESHELEIY 132
Fur_like cd07153
Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, ...
 37-148 1.34e-26

Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Ferric uptake regulator (Fur) and related metalloregulatory proteins are iron-dependent, DNA-binding repressors and activators mainly involved in iron metabolism. A general model for Fur repression under iron-rich conditions is that activated Fur (a dimer having one Fe2+ coordinated per monomer) binds to specific DNA sequences (Fur boxes) in the promoter region of iron-responsive genes, hindering access of RNA polymerase, and repressing transcription. Positive regulation by Fur can be direct or indirect, as in the Fur repression of an anti-sense regulatory small RNA. Some members sense metal ions other than Fe2+. For example, the zinc uptake regulator (Zur) responds to Zn2+, the manganese uptake regulator (Mur) responds to Mn2+, and the nickel uptake regulator (Nur) responds to Ni2+. Other members sense signals other than metal ions. For example, PerR, a metal-dependent sensor of hydrogen peroxide. PerR regulates DNA-binding activity through metal-based protein oxidation, and co-ordinates Mn2+ or Fe2+ at its regulatory site. Fur family proteins contain an N-terminal winged-helix DNA-binding domain followed by a dimerization domain; this CD spans both those domains.


Pssm-ID: 133478 [Multi-domain]  Cd Length: 116  Bit Score: 96.49  E-value: 1.34e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382177982  37 RQRVSLGWVLFARgDRHISAEMLYEEAMKEKIPVSLATIYNTLHQFTQAGLLRELAIDGAKTFFDTDSSEHHHFVVDGE- 115
Cdd:cd07153     1 PQRLAILEVLLES-DGHLTAEEIYERLRKKGPSISLATVYRTLELLEEAGLVREIELGDGKARYELNTDEHHHHLICTKc 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1382177982 116 NTVIDIPAEAVD-VAALPEPPEGYEIARVDVVVR 148
Cdd:cd07153    80 GKVIDFEDCPLEeLLEELAAKTGFKITSHRLELY 113
FUR pfam01475
Ferric uptake regulator family; This family includes metal ion uptake regulator proteins, that ...
 32-121 5.18e-19

Ferric uptake regulator family; This family includes metal ion uptake regulator proteins, that bind to the operator DNA and controls transcription of metal ion-responsive genes. This family is also known as the FUR family.


Pssm-ID: 426280  Cd Length: 121  Bit Score: 77.28  E-value: 5.18e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382177982  32 GLRPTRQRVSLGWVLFARGDRHISAEMLYEEAMKEKIPVSLATIYNTLHQFTQAGLLRELAIDGAKTFFDTDSSEHHHFV 111
Cdd:pfam01475   3 GLKLTPQRLKILEVLQKSDKEHLSAEEIYKELREEDPNISLATVYRTLNLLEEAGLVKRLEFDGGESRFELNTGHHHDHL 82

                          90
                  ....*....|.
gi 1382177982 112 VDGE-NTVIDI 121
Cdd:pfam01475  83 ICEDcGKVIEF 93
fur PRK09462
ferric uptake regulator; Provisional
 23-109 9.27e-10

ferric uptake regulator; Provisional


Pssm-ID: 236527  Cd Length: 148  Bit Score: 53.97  E-value: 9.27e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1382177982  23 DIRERLRRVGLRPTRQRVSLGWVLFARGDRHISAEMLYEEAMKEKIPVSLATIYNTLHQFTQAGLLRELAIDGAKTFFDT 102
Cdd:PRK09462    3 DNNTALKKAGLKVTLPRLKILEVLQEPDNHHVSAEDLYKRLIDMGEEIGLATVYRVLNQFDDAGIVTRHNFEGGKSVFEL 82


                  ....*..
gi 1382177982 103 dSSEHHH 109
Cdd:PRK09462   83 -TQQHHH 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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