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Conserved domains on  [gi|1381892985|ref|WP_107775149|]
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MULTISPECIES: OmpA family protein, partial [Bacteria]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10802 super family cl32581
peptidoglycan-associated lipoprotein Pal;
1-146 9.76e-53

peptidoglycan-associated lipoprotein Pal;


The actual alignment was detected with superfamily member PRK10802:

Pssm-ID: 182744 [Multi-domain]  Cd Length: 173  Bit Score: 164.66  E-value: 9.76e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381892985   1 MKKLAKVLMIAAPAFVLAACSS---------SSDNANANANANAGQFGGMTAEDLQ-------TRYNTVYFGFDSYAVEG 64
Cdd:PRK10802    3 LNKVLKGLMLALPVMAIAACSSnknasndqsEGMLGAGTGMDANGGNGNMSSEEQArlqmqqlQQNNIVYFDLDKYDIRS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381892985  65 EYQQLLDAHAAYLTS-ANGKVTVAGHADERGTPEYNIALGQRRADAVKNYLATKG--ANQVSTVSYGEEKPAVLGHTEAD 141
Cdd:PRK10802   83 DFAQMLDAHANFLRSnPSYKVTVEGHADERGTPEYNIALGERRANAVKMYLQGKGvsADQISIVSYGKEKPAVLGHDEAA 162


                  ....*
gi 1381892985 142 YAKNR 146
Cdd:PRK10802  163 YAKNR 167
 
Name Accession Description Interval E-value
PRK10802 PRK10802
peptidoglycan-associated lipoprotein Pal;
1-146 9.76e-53

peptidoglycan-associated lipoprotein Pal;


Pssm-ID: 182744 [Multi-domain]  Cd Length: 173  Bit Score: 164.66  E-value: 9.76e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381892985   1 MKKLAKVLMIAAPAFVLAACSS---------SSDNANANANANAGQFGGMTAEDLQ-------TRYNTVYFGFDSYAVEG 64
Cdd:PRK10802    3 LNKVLKGLMLALPVMAIAACSSnknasndqsEGMLGAGTGMDANGGNGNMSSEEQArlqmqqlQQNNIVYFDLDKYDIRS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381892985  65 EYQQLLDAHAAYLTS-ANGKVTVAGHADERGTPEYNIALGQRRADAVKNYLATKG--ANQVSTVSYGEEKPAVLGHTEAD 141
Cdd:PRK10802   83 DFAQMLDAHANFLRSnPSYKVTVEGHADERGTPEYNIALGERRANAVKMYLQGKGvsADQISIVSYGKEKPAVLGHDEAA 162


                  ....*
gi 1381892985 142 YAKNR 146
Cdd:PRK10802  163 YAKNR 167
Pal_lipo TIGR02802
peptidoglycan-associated lipoprotein; Members of this protein are Pal (also called OprL), the ...
 52-146 2.48e-52

peptidoglycan-associated lipoprotein; Members of this protein are Pal (also called OprL), the Peptidoglycan-Associated Lipoprotein of the Tol-Pal system. The system appears to be involved both in the maintenance of outer membrane integrity and in the import of certain organic molecules as nutrients. Members of this family contain a hydrodrophobic lipoprotein signal sequence, a conserved N-terminal cleavage and modification site, a poorly conserved low-complexity region, together comprising about 65 amino acids, and a well-conserved C-terminal domain. The seed alignment for this model includes only the conserved C-terminal domain.


Pssm-ID: 274307 [Multi-domain]  Cd Length: 104  Bit Score: 161.19  E-value: 2.48e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381892985  52 TVYFGFDSYAVEGEYQQLLDAHAAYLTS-ANGKVTVAGHADERGTPEYNIALGQRRADAVKNYLATKG--ANQVSTVSYG 128
Cdd:TIGR02802   1 RVYFDFDSSDLKSEAQATLDAHAQYLKKnPSVRVTIEGHTDERGTREYNLALGERRANAVKDYLQSKGvsASQIETVSYG 80

                          90
                  ....*....|....*...
gi 1381892985 129 EEKPAVLGHTEADYAKNR 146
Cdd:TIGR02802  81 KEKPAALGHDEAAWAKNR 98
OmpA_C-like cd07185
Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; ...
 52-146 5.00e-35

Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.


Pssm-ID: 143586 [Multi-domain]  Cd Length: 106  Bit Score: 117.27  E-value: 5.00e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381892985  52 TVYFGFDSYAVEGEYQQLLDAHAAYLTSANG-KVTVAGHADERGTPEYNIALGQRRADAVKNYLATKG--ANQVSTVSYG 128
Cdd:cd07185     3 TIYFDFGSAELTPEAKPLLDKLAEVLKKNPDaKIRIEGHTDSRGSDAYNQELSERRAEAVADYLVSKGvdASRITAVGYG 82

                          90
                  ....*....|....*...
gi 1381892985 129 EEKPAVLGHTEADYAKNR 146
Cdd:cd07185    83 ESRPIASNDTEEGRAKNR 100
OmpA COG2885
Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall ...
 25-146 3.68e-32

Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442131 [Multi-domain]  Cd Length: 294  Bit Score: 115.65  E-value: 3.68e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381892985  25 DNANANANANAGQFGGMTAEDLQTRYNTVYFGFDSYAVEGEYQQLLDAHAAYLTS-ANGKVTVAGHADERGTPEYNIALG 103
Cdd:COG2885   161 DAAAKAEAAAAAAALLPAAVAEVVLLSNVYFDFDSAELTPEAKAALDELAALLKEnPDLRIEIEGHTDSRGSDAYNLALS 240

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1381892985 104 QRRADAVKNYLATKG--ANQVSTVSYGEEKPAVLGHTEADYAKNR 146
Cdd:COG2885   241 ERRAEAVKDYLVSKGipASRITAVGYGESRPVASNDTEEGRAKNR 285
OmpA pfam00691
OmpA family; The Pfam entry also includes MotB and related proteins which are not included in ...
 55-145 1.87e-20

OmpA family; The Pfam entry also includes MotB and related proteins which are not included in the Prosite family.


Pssm-ID: 425825 [Multi-domain]  Cd Length: 95  Bit Score: 79.71  E-value: 1.87e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381892985  55 FGFDSYAVEGEYQQLLDAHAAYLTSAN--GKVTVAGHADERGTPEYNIALGQRRADAVKNYLATKG--ANQVSTVSYGEE 130
Cdd:pfam00691   1 FDPGSSQLTPKAKATLDEIADLLKFPElkNTITIEGHTDTVGSAAYNWELSQRRAEAVRRYLVNFGvpPSRISVVGYGAT 80

                          90
                  ....*....|....*
gi 1381892985 131 KPAVLGHTEADYAKN 145
Cdd:pfam00691  81 KPITDNKTPEGRARN 95
 
Name Accession Description Interval E-value
PRK10802 PRK10802
peptidoglycan-associated lipoprotein Pal;
1-146 9.76e-53

peptidoglycan-associated lipoprotein Pal;


Pssm-ID: 182744 [Multi-domain]  Cd Length: 173  Bit Score: 164.66  E-value: 9.76e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381892985   1 MKKLAKVLMIAAPAFVLAACSS---------SSDNANANANANAGQFGGMTAEDLQ-------TRYNTVYFGFDSYAVEG 64
Cdd:PRK10802    3 LNKVLKGLMLALPVMAIAACSSnknasndqsEGMLGAGTGMDANGGNGNMSSEEQArlqmqqlQQNNIVYFDLDKYDIRS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381892985  65 EYQQLLDAHAAYLTS-ANGKVTVAGHADERGTPEYNIALGQRRADAVKNYLATKG--ANQVSTVSYGEEKPAVLGHTEAD 141
Cdd:PRK10802   83 DFAQMLDAHANFLRSnPSYKVTVEGHADERGTPEYNIALGERRANAVKMYLQGKGvsADQISIVSYGKEKPAVLGHDEAA 162


                  ....*
gi 1381892985 142 YAKNR 146
Cdd:PRK10802  163 YAKNR 167
Pal_lipo TIGR02802
peptidoglycan-associated lipoprotein; Members of this protein are Pal (also called OprL), the ...
 52-146 2.48e-52

peptidoglycan-associated lipoprotein; Members of this protein are Pal (also called OprL), the Peptidoglycan-Associated Lipoprotein of the Tol-Pal system. The system appears to be involved both in the maintenance of outer membrane integrity and in the import of certain organic molecules as nutrients. Members of this family contain a hydrodrophobic lipoprotein signal sequence, a conserved N-terminal cleavage and modification site, a poorly conserved low-complexity region, together comprising about 65 amino acids, and a well-conserved C-terminal domain. The seed alignment for this model includes only the conserved C-terminal domain.


Pssm-ID: 274307 [Multi-domain]  Cd Length: 104  Bit Score: 161.19  E-value: 2.48e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381892985  52 TVYFGFDSYAVEGEYQQLLDAHAAYLTS-ANGKVTVAGHADERGTPEYNIALGQRRADAVKNYLATKG--ANQVSTVSYG 128
Cdd:TIGR02802   1 RVYFDFDSSDLKSEAQATLDAHAQYLKKnPSVRVTIEGHTDERGTREYNLALGERRANAVKDYLQSKGvsASQIETVSYG 80

                          90
                  ....*....|....*...
gi 1381892985 129 EEKPAVLGHTEADYAKNR 146
Cdd:TIGR02802  81 KEKPAALGHDEAAWAKNR 98
OmpA_C-like cd07185
Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; ...
 52-146 5.00e-35

Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.


Pssm-ID: 143586 [Multi-domain]  Cd Length: 106  Bit Score: 117.27  E-value: 5.00e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381892985  52 TVYFGFDSYAVEGEYQQLLDAHAAYLTSANG-KVTVAGHADERGTPEYNIALGQRRADAVKNYLATKG--ANQVSTVSYG 128
Cdd:cd07185     3 TIYFDFGSAELTPEAKPLLDKLAEVLKKNPDaKIRIEGHTDSRGSDAYNQELSERRAEAVADYLVSKGvdASRITAVGYG 82

                          90
                  ....*....|....*...
gi 1381892985 129 EEKPAVLGHTEADYAKNR 146
Cdd:cd07185    83 ESRPIASNDTEEGRAKNR 100
OmpA COG2885
Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall ...
 25-146 3.68e-32

Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442131 [Multi-domain]  Cd Length: 294  Bit Score: 115.65  E-value: 3.68e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381892985  25 DNANANANANAGQFGGMTAEDLQTRYNTVYFGFDSYAVEGEYQQLLDAHAAYLTS-ANGKVTVAGHADERGTPEYNIALG 103
Cdd:COG2885   161 DAAAKAEAAAAAAALLPAAVAEVVLLSNVYFDFDSAELTPEAKAALDELAALLKEnPDLRIEIEGHTDSRGSDAYNLALS 240

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1381892985 104 QRRADAVKNYLATKG--ANQVSTVSYGEEKPAVLGHTEADYAKNR 146
Cdd:COG2885   241 ERRAEAVKDYLVSKGipASRITAVGYGESRPVASNDTEEGRAKNR 285
OmpA pfam00691
OmpA family; The Pfam entry also includes MotB and related proteins which are not included in ...
 55-145 1.87e-20

OmpA family; The Pfam entry also includes MotB and related proteins which are not included in the Prosite family.


Pssm-ID: 425825 [Multi-domain]  Cd Length: 95  Bit Score: 79.71  E-value: 1.87e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381892985  55 FGFDSYAVEGEYQQLLDAHAAYLTSAN--GKVTVAGHADERGTPEYNIALGQRRADAVKNYLATKG--ANQVSTVSYGEE 130
Cdd:pfam00691   1 FDPGSSQLTPKAKATLDEIADLLKFPElkNTITIEGHTDTVGSAAYNWELSQRRAEAVRRYLVNFGvpPSRISVVGYGAT 80

                          90
                  ....*....|....*
gi 1381892985 131 KPAVLGHTEADYAKN 145
Cdd:pfam00691  81 KPITDNKTPEGRARN 95
MotB COG1360
Flagellar motor protein MotB [Cell motility];
53-146 1.67e-12

Flagellar motor protein MotB [Cell motility];


Pssm-ID: 440971 [Multi-domain]  Cd Length: 174  Bit Score: 61.40  E-value: 1.67e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381892985  53 VYFGFDSYAVEGEYQQLLDAHAAYLTSANGKVTVAGHADER--GTPEY--NIALGQRRADAVKNYLATKG--ANQVSTVS 126
Cdd:COG1360    61 VLFDSGSAELTPEGRELLDKIAAVLAEVPNRIRVEGHTDNVpiSTARFpsNWELSAARAAAVVRYLIEGGvpPERLSAVG 140

                          90       100
                  ....*....|....*....|
gi 1381892985 127 YGEEKPAVLGHTEADYAKNR 146
Cdd:COG1360   141 YGDTRPLAPNDTPEGRARNR 160
PRK10808 PRK10808
outer membrane protein A; Reviewed
 53-138 6.46e-12

outer membrane protein A; Reviewed


Pssm-ID: 236764 [Multi-domain]  Cd Length: 351  Bit Score: 61.63  E-value: 6.46e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381892985  53 VYFGFDSYAVEGEYQQLLDAHAAYLTSAN---GKVTVAGHADERGTPEYNIALGQRRADAVKNYLATKG--ANQVSTVSY 127
Cdd:PRK10808  226 VLFNFNKATLKPEGQQALDQLYSQLSNLDpkdGSVVVLGYTDRIGSDAYNQGLSEKRAQSVVDYLVSKGipADKISARGM 305

                          90
                  ....*....|.
gi 1381892985 128 GEEKPaVLGHT 138
Cdd:PRK10808  306 GKSNP-VTGNT 315
PRK10510 PRK10510
OmpA family lipoprotein;
84-146 2.84e-07

OmpA family lipoprotein;


Pssm-ID: 182507 [Multi-domain]  Cd Length: 219  Bit Score: 47.95  E-value: 2.84e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1381892985  84 VTVAGHADERGTPEYNIALGQRRADAVKNYLATKG--ANQVSTVSYGEEKPAVLGHTEADYAKNR 146
Cdd:PRK10510  146 VNVVGYTDSTGSHDLNMRLSQQRADSVASALITQGvdASRIRTQGMGPANPIASNSTAEGKAQNR 210
PRK07033 PRK07033
DotU family type VI secretion system protein;
55-146 2.95e-07

DotU family type VI secretion system protein;


Pssm-ID: 180801 [Multi-domain]  Cd Length: 427  Bit Score: 48.12  E-value: 2.95e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381892985  55 FGFDSYAVEGEYQQLLDAHAAYLTSANGKVTVAGHADER--GTPEY--NIALGQRRADAVKNYLATK--GANQVSTVSYG 128
Cdd:PRK07033  318 FASASTSVRDRYQPVLARVADALNQVKGNVLVTGYSDNVpiRTARFpsNWELSQARAQAVRALLAARlgQPERVTAEGRG 397

                          90
                  ....*....|....*...
gi 1381892985 129 EEKPAVLGHTEADYAKNR 146
Cdd:PRK07033  398 DSDPVAPNDSAENRARNR 415
PRK09039 PRK09039
peptidoglycan -binding protein;
86-146 4.44e-06

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 44.57  E-value: 4.44e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1381892985  86 VAGHADER---GTPEY--NIALGQRRADAVKNYLATKG--ANQVSTVSYGEEKPAVLGHTEADYAKNR 146
Cdd:PRK09039  267 VDGHTDNVplsGTGRFrdNWELSSARAISVVKFLIALGvpADRLAAAGFGEFQPLDPGDTPEARARNR 334
PRK09967 PRK09967
OmpA family protein;
51-146 7.83e-05

OmpA family protein;


Pssm-ID: 182172 [Multi-domain]  Cd Length: 160  Bit Score: 40.35  E-value: 7.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381892985  51 NTVYFGFDSYAVEGEYQQLLDAHAAYLTSANGK-VTVAGHADERGTPEYNIALGQRRADAVKNYLAtKGAN----QVSTV 125
Cdd:PRK09967   52 DAILFAKNDYKLLPESQQQIQTMAAKLASTGLThARMDGHTDNYGEDSYNEGLSLKRANVVADAWA-MGGQiprsNLTTQ 130

                          90       100
                  ....*....|....*....|.
gi 1381892985 126 SYGEEKPAVLGHTEADYAKNR 146
Cdd:PRK09967  131 GLGKKYPIASNKTAQGRAENR 151
PRK06925 PRK06925
flagellar motor protein MotB;
69-146 4.03e-04

flagellar motor protein MotB;


Pssm-ID: 235887 [Multi-domain]  Cd Length: 230  Bit Score: 38.98  E-value: 4.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381892985  69 LLDAHAAYLTSANGKVTVAGHADERGTPEY----NIALGQRRADAVKNYLATK---GANQVSTVSYGEEKPAVLGHTEAD 141
Cdd:PRK06925  136 FLHKIGVLLSTIPNDIKVEGHTDSRPISTYrypsNWELSAARASSVIRYFTSKeklDSSRFIAVGYADTKPVVPNTTEEN 215


                  ....*
gi 1381892985 142 YAKNR 146
Cdd:PRK06925  216 MQENR 220
motB PRK08944
flagellar motor protein MotB; Reviewed
 65-146 2.52e-03

flagellar motor protein MotB; Reviewed


Pssm-ID: 236356 [Multi-domain]  Cd Length: 302  Bit Score: 36.53  E-value: 2.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381892985  65 EYQQLLDAHAAYLTSANGKVTVAGHADERGTP--EY--NIALGQRRADAVKNYL-ATKG--ANQVSTVSYGEEKPAVLGH 137
Cdd:PRK08944  193 KFKPVVRKIGELLKDVPGIITVSGHTDNVPISseLYrsNWDLSSARAVAVAHELlKVKGfdPQRLKVVGMADTQPLVPND 272


                  ....*....
gi 1381892985 138 TEADYAKNR 146
Cdd:PRK08944  273 TAENRARNR 281
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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