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Conserved domains on  [gi|1337428514|ref|WP_103272016|]
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MULTISPECIES: heme o synthase [unclassified Achromobacter]

Protein Classification

protoheme IX farnesyltransferase( domain architecture ID 10792362)

protoheme IX farnesyltransferase acts in step 1 of the conversion protoheme IX to heme O in heme O biosynthesis

EC:  2.5.1.141
Gene Ontology:  GO:0016765|GO:0008495|GO:0006783|GO:0016740|GO:0048034
PubMed:  7885224|34428995

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK04375 PRK04375
protoheme IX farnesyltransferase; Provisional
 3-296 1.93e-143

protoheme IX farnesyltransferase; Provisional


:

Pssm-ID: 235293  Cd Length: 296  Bit Score: 405.29  E-value: 1.93e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514   3 SLAAPQSGLLRQYLVLTKPRVTQLAVFCAVIGMFLAAPGIPDMQRVLFGTLGIWLLAAAAFAINCLIEQEVDARMLRTAR 82
Cdd:PRK04375    1 VSSSSSRATLKDYLALTKPRVISLNLFTALGGMLLAPPGVPPLLLLLLTLLGIALVAGAAGALNNYIDRDIDAKMERTKN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514  83 RATARGTISAYQVLSLSGLLGGAGMFVLYHMVNPLTMWLTFATFVGYAVIYTVILKPRTPQNIVIGGLSGAMPPALGWAA 162
Cdd:PRK04375   81 RPLVTGRISPREALIFGLVLGVLGFLLLGLFVNPLAAWLTLAGIFFYVVVYTLWLKRRTPQNIVIGGAAGAMPPLIGWAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514 163 VADSVPAEAWVLVLIIFIWTPPHFWALALYRNHDYAKAGLPMLPVTHGQQFTRLHILLYSVALLATTLLPYIILMSGVLY 242
Cdd:PRK04375  161 VTGSLSWEALILFLIIFLWTPPHFWALAIFRKDDYAAAGIPMLPVVKGIRVTKRQILLYTVLLVAVSLLPVLLGMAGLLY 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1337428514 243 LTAALVLGGMFLSYAWRLYREYSDELARSMFRFSILYLALLFGALLVDHWVGLL 296
Cdd:PRK04375  241 LVVALLLGAWFLYYAWRLYRKDDRKWARKLFRYSINYLTLLFVALLVDHLLLLS 294
 
Name Accession Description Interval E-value
PRK04375 PRK04375
protoheme IX farnesyltransferase; Provisional
 3-296 1.93e-143

protoheme IX farnesyltransferase; Provisional


Pssm-ID: 235293  Cd Length: 296  Bit Score: 405.29  E-value: 1.93e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514   3 SLAAPQSGLLRQYLVLTKPRVTQLAVFCAVIGMFLAAPGIPDMQRVLFGTLGIWLLAAAAFAINCLIEQEVDARMLRTAR 82
Cdd:PRK04375    1 VSSSSSRATLKDYLALTKPRVISLNLFTALGGMLLAPPGVPPLLLLLLTLLGIALVAGAAGALNNYIDRDIDAKMERTKN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514  83 RATARGTISAYQVLSLSGLLGGAGMFVLYHMVNPLTMWLTFATFVGYAVIYTVILKPRTPQNIVIGGLSGAMPPALGWAA 162
Cdd:PRK04375   81 RPLVTGRISPREALIFGLVLGVLGFLLLGLFVNPLAAWLTLAGIFFYVVVYTLWLKRRTPQNIVIGGAAGAMPPLIGWAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514 163 VADSVPAEAWVLVLIIFIWTPPHFWALALYRNHDYAKAGLPMLPVTHGQQFTRLHILLYSVALLATTLLPYIILMSGVLY 242
Cdd:PRK04375  161 VTGSLSWEALILFLIIFLWTPPHFWALAIFRKDDYAAAGIPMLPVVKGIRVTKRQILLYTVLLVAVSLLPVLLGMAGLLY 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1337428514 243 LTAALVLGGMFLSYAWRLYREYSDELARSMFRFSILYLALLFGALLVDHWVGLL 296
Cdd:PRK04375  241 LVVALLLGAWFLYYAWRLYRKDDRKWARKLFRYSINYLTLLFVALLVDHLLLLS 294
CyoE COG0109
Polyprenyltransferase (heme O synthase) [Coenzyme transport and metabolism, Lipid transport ...
 2-295 1.43e-129

Polyprenyltransferase (heme O synthase) [Coenzyme transport and metabolism, Lipid transport and metabolism];


Pssm-ID: 439879  Cd Length: 299  Bit Score: 370.23  E-value: 1.43e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514   2 TSLAAPQSGLLRQYLVLTKPRVTQLAVFCAVIGMFLAAPGIPDMQRVLFGTLGIWLLAAAAFAINCLIEQEVDARMLRTA 81
Cdd:COG0109     6 ASSAASLRSTLRDYLALTKPRIILLLLFTALAGMLLAAGGLPDLLLLLLTLLGGALAAGAANALNNYIDRDIDALMKRTK 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514  82 RRATARGTISAYQVLSLSGLLGGAGMFVLYHMVNPLTMWLTFATFVGYAVIYTVILKPRTPQNIVIGGLSGAMPPALGWA 161
Cdd:COG0109    86 NRPLPTGRISPREALIFGLVLGVLGLALLALFVNPLAALLGLLGIFFYVVVYTLWLKRRTPQNIVIGGAAGAMPPLIGWA 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514 162 AVADSVPAEAWVLVLIIFIWTPPHFWALALYRNHDYAKAGLPMLPVTHGQQFTRLHILLYSVALLATTLLPYIILMSGVL 241
Cdd:COG0109   166 AVTGSLSLEALLLFLIIFLWTPPHFWALALKRRDDYARAGVPMLPVVKGERRTKRQILLYTLLLVPVSLLPYLLGMAGLI 245

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1337428514 242 YLTAALVLGGMFLSYAWRLYREYSDELARSMFRFSILYLALLFGALLVDHWVGL 295
Cdd:COG0109   246 YLVVALVLGAWFLYLAVRLYRRPDRKWARKLFKFSILYLTLLFLALLVDHLLLL 299
PT_UbiA_Cox10 cd13957
Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase (also called heme O ...
 16-286 1.11e-104

Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase (also called heme O synthase, heme A:farnesyltransferase, cytochrome c oxidase subunit X [Cox10]) converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of the heme B porphyrin ring with a hydroxyethyl farnesyl side group. It is localized at the mitochondrial inner membrane. Eukaryotic Cox10 is important for the maturation of the heme A prosthetic group of cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, that catalyzes the electron transfer from reduced cytochrome c to oxygen. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260120  Cd Length: 271  Bit Score: 305.90  E-value: 1.11e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514  16 LVLTKPRVTQLAVFCAVIGMFLAAPGIPDMQRVLFGTLGIWLLAAAAFAINCLIEQEVDARMLRTARRATARGTISAYQV 95
Cdd:cd13957     1 LELTKPRITLLVLLTALAGYLLAPGGVPDLLLLLLTLLGTALVSASANALNQYIERDIDAKMKRTRNRPLPSGRISPKHA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514  96 LSLSGLLGGAGMFVLYHMVNPLTMWLTFATFVGYAVIYTVILKPRTPQNIVIGGLSGAMPPALGWAAVADSVPAEAWVLV 175
Cdd:cd13957    81 LIFGLVLGILGLALLALFVNPLTALLGLLGIFLYVFVYTPLKKRTTPLNTVIGGIAGAIPPLIGWAAATGSLDLGAWLLF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514 176 LIIFIWTPPHFWALALYRNHDYAKAGLPMLPVTHGQQFTRLHILLYSVALLATTLLPYIILMSGVLYLTAALVLGGMFLS 255
Cdd:cd13957   161 LILFLWQPPHFWALAILYRDDYARAGIPMLPVVKGERRTKRQILLYTLLLVPLSLLLYLLGLTGWIYLVVALLLGLYFLY 240

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1337428514 256 YAWRLYREYSDELARSMFRFSILYLALLFGA 286
Cdd:cd13957   241 LAIKLYRSPDDKWARKLFFASLIYLPLLFLL 271
cyoE_ctaB TIGR01473
protoheme IX farnesyltransferase; This model describes protoheme IX farnesyltransferase, also ...
 13-290 5.87e-91

protoheme IX farnesyltransferase; This model describes protoheme IX farnesyltransferase, also called heme O synthase, an enzyme that creates an intermediate in the biosynthesis of heme A. Prior to the description of its enzymatic function, this protein was often called a cytochrome o ubiquinol oxidase assembly factor. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 273645  Cd Length: 280  Bit Score: 271.43  E-value: 5.87e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514  13 RQYLVLTKPRVTQLAVFCAVIGMFLAA-PGIPDMQRVLFGTLGIWLLAAAAFAINCLIEQEVDARMLRTARRATARGTIS 91
Cdd:TIGR01473   1 KDYLQLTKPRIISLLLITAFAGMWLAPgGALVNPPLLLLTLLGTTLAAASANAFNMYIDRDIDKKMKRTRNRPLVTGRIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514  92 AYQVLSLSGLLGGAGMFVLYHMVNPLTMWLTFATFVGYAVIYTVILKPRTPQNIVIGGLSGAMPPALGWAAVADSVPAEA 171
Cdd:TIGR01473  81 PREALAFGLLLGVLGVAILAAFVNPLAALLGLFGIFFYVIVYTIWLKRRTPQNTVIGGFAGAVPPLIGWAAVTGSISLGA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514 172 WVLVLIIFIWTPPHFWALALYRNHDYAKAGLPMLPVTHGQQFTRLHILLYSVALLATTLLPYIILMSGVLYLTAALVLGG 251
Cdd:TIGR01473 161 WLLFAIIFLWQPPHFWALALKYKDDYRAAGIPMLPVVKGERITKRQIALYTAALLPVSLLLAFLGGTGWLYLIVATLLGA 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1337428514 252 MFLSYAWRLYREYSD-ELARSMFRFSILYLALLFGALLVD 290
Cdd:TIGR01473 241 LFLYLAFKFYRDPTDrKKARKLFKFSLIYLALLFVALLID 280
UbiA pfam01040
UbiA prenyltransferase family;
27-278 4.22e-47

UbiA prenyltransferase family;


Pssm-ID: 460038 [Multi-domain]  Cd Length: 250  Bit Score: 158.16  E-value: 4.22e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514  27 AVFCAVIGMFLAAPGIPDMQRVLFGTLGIWLLAAAAFAINCLIEQEVDARMLRTARRATARGTISAYQVLSLSGLLGGAG 106
Cdd:pfam01040   1 LLIPALAGLALAAGGVPDLLLLLLALLGTVLARAAANALNDYYDRDIDAIMPRTPNRPLPSGRISPREALIFALVLLALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514 107 MFVLYhMVNPLTMWLTFATFVGYaVIYTVILKPRTPQNIVIGGLSGAMPPALGWAAVADSVPAEAWVLVLIIFIWTPPHF 186
Cdd:pfam01040  81 LLLLL-LLNPLTALLGLAALLLY-VLYTLRLKRRTLLGQLVGGLAFGLPPLLGWAAVTGSLSPLALLLALALFLWTWAIA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514 187 WALALYRNHDYAKAGLPMLPVTHGQQFTRLHILLYSVALLATTLLPYIILMSGVLYLTAALVLGGMFLSYAWRLYREYSD 266
Cdd:pfam01040 159 LANDLRDREDDRKAGIKTLPVVLGRKAARILLALLLAVALLLLLLLLLLLLGGLYLLLALLLAALALLYAARLLRLRDPK 238

                         250
                  ....*....|..
gi 1337428514 267 ELARSMFRFSIL 278
Cdd:pfam01040 239 KDAKAFFFLSSL 250
 
Name Accession Description Interval E-value
PRK04375 PRK04375
protoheme IX farnesyltransferase; Provisional
 3-296 1.93e-143

protoheme IX farnesyltransferase; Provisional


Pssm-ID: 235293  Cd Length: 296  Bit Score: 405.29  E-value: 1.93e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514   3 SLAAPQSGLLRQYLVLTKPRVTQLAVFCAVIGMFLAAPGIPDMQRVLFGTLGIWLLAAAAFAINCLIEQEVDARMLRTAR 82
Cdd:PRK04375    1 VSSSSSRATLKDYLALTKPRVISLNLFTALGGMLLAPPGVPPLLLLLLTLLGIALVAGAAGALNNYIDRDIDAKMERTKN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514  83 RATARGTISAYQVLSLSGLLGGAGMFVLYHMVNPLTMWLTFATFVGYAVIYTVILKPRTPQNIVIGGLSGAMPPALGWAA 162
Cdd:PRK04375   81 RPLVTGRISPREALIFGLVLGVLGFLLLGLFVNPLAAWLTLAGIFFYVVVYTLWLKRRTPQNIVIGGAAGAMPPLIGWAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514 163 VADSVPAEAWVLVLIIFIWTPPHFWALALYRNHDYAKAGLPMLPVTHGQQFTRLHILLYSVALLATTLLPYIILMSGVLY 242
Cdd:PRK04375  161 VTGSLSWEALILFLIIFLWTPPHFWALAIFRKDDYAAAGIPMLPVVKGIRVTKRQILLYTVLLVAVSLLPVLLGMAGLLY 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1337428514 243 LTAALVLGGMFLSYAWRLYREYSDELARSMFRFSILYLALLFGALLVDHWVGLL 296
Cdd:PRK04375  241 LVVALLLGAWFLYYAWRLYRKDDRKWARKLFRYSINYLTLLFVALLVDHLLLLS 294
CyoE COG0109
Polyprenyltransferase (heme O synthase) [Coenzyme transport and metabolism, Lipid transport ...
 2-295 1.43e-129

Polyprenyltransferase (heme O synthase) [Coenzyme transport and metabolism, Lipid transport and metabolism];


Pssm-ID: 439879  Cd Length: 299  Bit Score: 370.23  E-value: 1.43e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514   2 TSLAAPQSGLLRQYLVLTKPRVTQLAVFCAVIGMFLAAPGIPDMQRVLFGTLGIWLLAAAAFAINCLIEQEVDARMLRTA 81
Cdd:COG0109     6 ASSAASLRSTLRDYLALTKPRIILLLLFTALAGMLLAAGGLPDLLLLLLTLLGGALAAGAANALNNYIDRDIDALMKRTK 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514  82 RRATARGTISAYQVLSLSGLLGGAGMFVLYHMVNPLTMWLTFATFVGYAVIYTVILKPRTPQNIVIGGLSGAMPPALGWA 161
Cdd:COG0109    86 NRPLPTGRISPREALIFGLVLGVLGLALLALFVNPLAALLGLLGIFFYVVVYTLWLKRRTPQNIVIGGAAGAMPPLIGWA 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514 162 AVADSVPAEAWVLVLIIFIWTPPHFWALALYRNHDYAKAGLPMLPVTHGQQFTRLHILLYSVALLATTLLPYIILMSGVL 241
Cdd:COG0109   166 AVTGSLSLEALLLFLIIFLWTPPHFWALALKRRDDYARAGVPMLPVVKGERRTKRQILLYTLLLVPVSLLPYLLGMAGLI 245

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1337428514 242 YLTAALVLGGMFLSYAWRLYREYSDELARSMFRFSILYLALLFGALLVDHWVGL 295
Cdd:COG0109   246 YLVVALVLGAWFLYLAVRLYRRPDRKWARKLFKFSILYLTLLFLALLVDHLLLL 299
PT_UbiA_Cox10 cd13957
Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase (also called heme O ...
 16-286 1.11e-104

Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase (also called heme O synthase, heme A:farnesyltransferase, cytochrome c oxidase subunit X [Cox10]) converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of the heme B porphyrin ring with a hydroxyethyl farnesyl side group. It is localized at the mitochondrial inner membrane. Eukaryotic Cox10 is important for the maturation of the heme A prosthetic group of cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, that catalyzes the electron transfer from reduced cytochrome c to oxygen. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260120  Cd Length: 271  Bit Score: 305.90  E-value: 1.11e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514  16 LVLTKPRVTQLAVFCAVIGMFLAAPGIPDMQRVLFGTLGIWLLAAAAFAINCLIEQEVDARMLRTARRATARGTISAYQV 95
Cdd:cd13957     1 LELTKPRITLLVLLTALAGYLLAPGGVPDLLLLLLTLLGTALVSASANALNQYIERDIDAKMKRTRNRPLPSGRISPKHA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514  96 LSLSGLLGGAGMFVLYHMVNPLTMWLTFATFVGYAVIYTVILKPRTPQNIVIGGLSGAMPPALGWAAVADSVPAEAWVLV 175
Cdd:cd13957    81 LIFGLVLGILGLALLALFVNPLTALLGLLGIFLYVFVYTPLKKRTTPLNTVIGGIAGAIPPLIGWAAATGSLDLGAWLLF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514 176 LIIFIWTPPHFWALALYRNHDYAKAGLPMLPVTHGQQFTRLHILLYSVALLATTLLPYIILMSGVLYLTAALVLGGMFLS 255
Cdd:cd13957   161 LILFLWQPPHFWALAILYRDDYARAGIPMLPVVKGERRTKRQILLYTLLLVPLSLLLYLLGLTGWIYLVVALLLGLYFLY 240

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1337428514 256 YAWRLYREYSDELARSMFRFSILYLALLFGA 286
Cdd:cd13957   241 LAIKLYRSPDDKWARKLFFASLIYLPLLFLL 271
cyoE_ctaB TIGR01473
protoheme IX farnesyltransferase; This model describes protoheme IX farnesyltransferase, also ...
 13-290 5.87e-91

protoheme IX farnesyltransferase; This model describes protoheme IX farnesyltransferase, also called heme O synthase, an enzyme that creates an intermediate in the biosynthesis of heme A. Prior to the description of its enzymatic function, this protein was often called a cytochrome o ubiquinol oxidase assembly factor. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 273645  Cd Length: 280  Bit Score: 271.43  E-value: 5.87e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514  13 RQYLVLTKPRVTQLAVFCAVIGMFLAA-PGIPDMQRVLFGTLGIWLLAAAAFAINCLIEQEVDARMLRTARRATARGTIS 91
Cdd:TIGR01473   1 KDYLQLTKPRIISLLLITAFAGMWLAPgGALVNPPLLLLTLLGTTLAAASANAFNMYIDRDIDKKMKRTRNRPLVTGRIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514  92 AYQVLSLSGLLGGAGMFVLYHMVNPLTMWLTFATFVGYAVIYTVILKPRTPQNIVIGGLSGAMPPALGWAAVADSVPAEA 171
Cdd:TIGR01473  81 PREALAFGLLLGVLGVAILAAFVNPLAALLGLFGIFFYVIVYTIWLKRRTPQNTVIGGFAGAVPPLIGWAAVTGSISLGA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514 172 WVLVLIIFIWTPPHFWALALYRNHDYAKAGLPMLPVTHGQQFTRLHILLYSVALLATTLLPYIILMSGVLYLTAALVLGG 251
Cdd:TIGR01473 161 WLLFAIIFLWQPPHFWALALKYKDDYRAAGIPMLPVVKGERITKRQIALYTAALLPVSLLLAFLGGTGWLYLIVATLLGA 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1337428514 252 MFLSYAWRLYREYSD-ELARSMFRFSILYLALLFGALLVD 290
Cdd:TIGR01473 241 LFLYLAFKFYRDPTDrKKARKLFKFSLIYLALLFVALLID 280
UbiA pfam01040
UbiA prenyltransferase family;
27-278 4.22e-47

UbiA prenyltransferase family;


Pssm-ID: 460038 [Multi-domain]  Cd Length: 250  Bit Score: 158.16  E-value: 4.22e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514  27 AVFCAVIGMFLAAPGIPDMQRVLFGTLGIWLLAAAAFAINCLIEQEVDARMLRTARRATARGTISAYQVLSLSGLLGGAG 106
Cdd:pfam01040   1 LLIPALAGLALAAGGVPDLLLLLLALLGTVLARAAANALNDYYDRDIDAIMPRTPNRPLPSGRISPREALIFALVLLALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514 107 MFVLYhMVNPLTMWLTFATFVGYaVIYTVILKPRTPQNIVIGGLSGAMPPALGWAAVADSVPAEAWVLVLIIFIWTPPHF 186
Cdd:pfam01040  81 LLLLL-LLNPLTALLGLAALLLY-VLYTLRLKRRTLLGQLVGGLAFGLPPLLGWAAVTGSLSPLALLLALALFLWTWAIA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514 187 WALALYRNHDYAKAGLPMLPVTHGQQFTRLHILLYSVALLATTLLPYIILMSGVLYLTAALVLGGMFLSYAWRLYREYSD 266
Cdd:pfam01040 159 LANDLRDREDDRKAGIKTLPVVLGRKAARILLALLLAVALLLLLLLLLLLLGGLYLLLALLLAALALLYAARLLRLRDPK 238

                         250
                  ....*....|..
gi 1337428514 267 ELARSMFRFSIL 278
Cdd:pfam01040 239 KDAKAFFFLSSL 250
PLN02776 PLN02776
prenyltransferase
 18-289 4.02e-38

prenyltransferase


Pssm-ID: 215415  Cd Length: 341  Bit Score: 137.57  E-value: 4.02e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514  18 LTKPRVTQLAVFCAVIGMFLAAPGIPDMQRVLFGTLGIWLLAAAAFAINCLIEQEVDARMLRTARRATARGTISAYQVLS 97
Cdd:PLN02776    1 LSKARLSALVVATSGAGFVLGSGEAIDLPGLGWTCAGTMLCAASANTLNQVFEVKNDSKMKRTMRRPLPSGRISVPHAVA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514  98 LSGLLGGAGMFVLYHMVNPLTMWLTFATFVGYAVIYTViLKPRTPQNIVIGGLSGAMPPALGWAAVADSVPAEAWVLVLI 177
Cdd:PLN02776   81 WAVVVGAAGVALLAYKTNMLTAGLGAGNILLYAFVYTP-LKQIHPANTWVGAVVGAIPPLMGWAAASGQLDAGAMVLAAA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514 178 IFIWTPPHFWALA-LYRNhDYAKAGLPMLPVTH--GQQfTRLHILLYSVALLATTLLPYIILMSGVLYLTAALVLGGMFL 254
Cdd:PLN02776  160 LYFWQMPHFMALAyMCRD-DYAAGGYRMLSLADatGRR-TALVALRNCLYLAPLGFLAYDWGVTSSPFALEAALLTAYLA 237

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1337428514 255 SYAWRLYREYSDELARSMFRFSILYLALLFGALLV 289
Cdd:PLN02776  238 ASAASFYREPTNANARKMFHGSLLYLPAFMALLLL 272
UbiA COG0382
4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate ...
 18-289 2.98e-21

4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate polyprenyltransferase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440151  Cd Length: 280  Bit Score: 90.67  E-value: 2.98e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514  18 LTKPRVTQLAVFCAVIGMFLAAPGIPDMQRVLFGTLGIWLLAAAAFAINCLIEQEVDARMLRTARRATARGTISAYQVLS 97
Cdd:COG0382     9 LDRPIGILLLLWPTLWALFLAAGGLPDLLLLLLAVLGTVLMRSAGYVINDYFDREIDRINERKPNRPLASGRISLREALL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514  98 LSGLLGGAGMFVLYhMVNPLTMWLTFATFVGyAVIYTVILKPRTPQNIVIGGLSGAMPPALGWAAVADSVPAEAWVLVLI 177
Cdd:COG0382    89 LAIVLLLLALALAL-LLNPLTFLLALAALAL-AWAYSLFLKRFTLLGNLVLGLLFGLGILMGFAAVTGSLPLSAWLLALA 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514 178 IFIWTpphfWAL----ALYRNHDYAKAGLPMLPVTHGQQFTRLHILLYSVALLATTLLPYIILMSGVLYLTAALVLGGMF 253
Cdd:COG0382   167 AFLWT----LAYdtiyDLEDREGDRKIGIKTLAILFGVRDALIIAGVLYALAVLLLLLLGLLAGLGLLYLLGLLAALLLL 242

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1337428514 254 LSYAWRLYREYSDE--LARSMFRFSILYLALLFGALLV 289
Cdd:COG0382   243 YLSQLWLLRPRKKDpaRALKLFKLNMLLGLLLFLGIAL 280
PT_UbiA_COQ2 cd13959
4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known ...
 18-290 5.72e-18

4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known as Coq2, catalyzes the prenylation of p-hydroxybenzoate with an all-trans polyprenyl group, an important step in ubiquinone (CoQ) biosynthesis. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260122 [Multi-domain]  Cd Length: 272  Bit Score: 81.74  E-value: 5.72e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514  18 LTKPRVTQLAVFCAVIGMFLAAPGIPD--MQRVLFGTLGIWLLAAAAFAINCLIEQEVDARMLRTARRATARGTISAYQV 95
Cdd:cd13959     3 LDKPIGTLLLLPPALWGLLLAAGGLPLplLKLLLLFLLGAFLMRSAGCTINDIADRDIDAKVPRTKNRPLASGAISVKEA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514  96 LSLSGLLGGAGMFVLYhMVNPLTMWLTFATFVGyAVIYtvilkPRT------PQniVIGGLSGAMPPALGWAAVADSVPA 169
Cdd:cd13959    83 LLFLAVQLLLGLALLL-QLNPLTILLSPIALLL-VLIY-----PLMkrftywPQ--LVLGLAFGWGPLMGWAAVTGSLPL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514 170 EAWVLVLIIFIWTpphfwalALY--------RNHDyAKAGLPMLPVTHGqQFTRLHILLYSVALLATTLLPYIILMSGVL 241
Cdd:cd13959   154 PALLLYLAVIFWT-------AGYdtiyahqdREDD-RKIGVKSTAVLFG-DRTKLILALLLHLFVALLLLAGGLAGLGWP 224

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1337428514 242 YLTAALVLGGMFLsYAWRLYREYSDELARSMFRFSILYLALLFGALLVD 290
Cdd:cd13959   225 YYLGLGAAAHLLW-QEHRLDLPDPLRSCLAFFLSNGWVGLLLFAGLLLD 272
ubiA PRK12886
prenyltransferase; Reviewed
 12-296 2.71e-12

prenyltransferase; Reviewed


Pssm-ID: 237247  Cd Length: 291  Bit Score: 65.87  E-value: 2.71e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514  12 LRQYLVLTKPRVTQLAVFCAVIGMFLAAPGIPDMQRVLFGTLGIWLLAAAAFAINCLIEQEVDARMLRTARRATARGTIS 91
Cdd:PRK12886    8 LKVFLEMIKFSHTLFALPFAGIGAVLAALGLPGASQLDWILMAMVGARTAAMGFNRLIDAEIDARNPRTAGRAIPAGLIS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514  92 AYQVLsLSGLLGGAGMFVLYHMVNPLTMWLTFATfVGYAVIYTvILKPRTPQNIVIGGLSGAMPPALGWAAVADSVPAEA 171
Cdd:PRK12886   88 KGSAI-LFIVLSSLLMLFAAWFLNPLCLYLSPPA-LFFLLLYS-YCKRFTALAHVVLGFCLALAPLGAWIAIRGTIELPA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514 172 WVLVLIIFIWTPPHFWALALYRNHDYAKAGLPMLPVTHGQQFTRLHILLYSVALLATTLLPYIILMSGVLYLTAALVLGG 251
Cdd:PRK12886  165 ILLGLAVLFWVAGFDILYALQDLEFDRKEGLHSIPAKLGVNGSLWIARVFHLLMIGFLFALGISAGLGPWFLAGLAVTGI 244

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1337428514 252 MFLSYAWRLYREYSDELARSMFRFSILYLALLFGALLVDHWVGLL 296
Cdd:PRK12886  245 LLLYEHWLLRGGDLTRLDAAFFNMNGYISVTLFAATLFDRLFYFG 289
PT_UbiA cd13956
UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA ...
 35-289 1.13e-11

UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260119 [Multi-domain]  Cd Length: 271  Bit Score: 63.91  E-value: 1.13e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514  35 MFLAAPGIPDMQRVLFGTLGIWLLAAAAFAINCLIEQEVDArmLRTARRATARGTISAYQVLSLSGLLGGAGMFVLYHmV 114
Cdd:cd13956    21 ALAGAFAGPLPALLLLALLAVFLGAGAGYALNDYTDRELDA--INKPDRPLPSGRLSPRQALAFAAALLLVGLALALA-L 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514 115 NPLTMWLTFATFVGyAVIYTVILKPRT-PQNIVIGGLSGAMPPALGWAAVADSVPAEAWVLVLIIFIW-TPPHFWALALY 192
Cdd:cd13956    98 GPLALLLLLAGLLL-GLAYSLGLKRLKlGGWGVLGYATGLALLPGLGAVAAGGLVPLALLLALVFLLLgLGINLYNDLPD 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514 193 RNHDyAKAGLPMLPVTHGQQFT-RLHILLYSVALLATTLLPYIILMSGVLYLTAALVLGGMFLSYAWRLYREYSDELARS 271
Cdd:cd13956   177 VEGD-RAAGIRTLPVRLGPRRArRLAAGLLLAALILVVLLAVAGLLGPLALLALLAVALLALRARFARADRLPALPRGFL 255

                         250
                  ....*....|....*...
gi 1337428514 272 MFRFsilYLALLFGALLV 289
Cdd:cd13956   256 LLAV---YRLLLFAALLL 270
ubiA PRK12884
prenyltransferase; Reviewed
 12-289 1.67e-10

prenyltransferase; Reviewed


Pssm-ID: 183812  Cd Length: 279  Bit Score: 60.36  E-value: 1.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514  12 LRQYLVLTKPRVTQLAVFCAVIGMFLAAPGIPDMQrVLFGTLGIWLLAAAAFAINCLIEQEVDaRMLRTaRRATARGTIS 91
Cdd:PRK12884    4 MKAYLELLRPEHGLMAGIAVVLGAIIALGGLPLDE-ALLGFLTAFFASGSANALNDYFDYEVD-RINRP-DRPIPSGRIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514  92 AYQVLSLSGLLGGAGmFVLYHMVNPLTMWLTFAtFVGYAVIYTVILKPR-TPQNIVIGGLSGaMPPALGWAAVADsVPAE 170
Cdd:PRK12884   81 RREALLLAILLFILG-LIAAYLISPLAFLVVIL-VSVLGILYNWKLKEYgLIGNLYVAFLTG-MTFIFGGIAVGE-LNEA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514 171 AWVLVLIIFIWTPPHFWALALYRNHDYAKAGLPMLPVTHGQQFT-RLHILLYSVALLaTTLLPYIILMSGVLYLTAALVL 249
Cdd:PRK12884  157 VILLAAMAFLMTLGREIMKDIEDVEGDRLRGARTLAILYGEKIAgRIAAALFILAVL-LSPLPYLFGIFNILYLAPVLVA 235

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1337428514 250 GGMFLSYAWRLYREYSDELARSMFRFSILYLALLFGALLV 289
Cdd:PRK12884  236 DLIFLYSAYSLLRSQDRETIRKVRKITLTAMLLALVAFAL 275
PT_UbiA_DGGGPS cd13961
Geranylgeranylglycerol-phosphate geranylgeranyltransferase; Digeranylgeranylglyceryl phosphate ...
 15-287 1.70e-08

Geranylgeranylglycerol-phosphate geranylgeranyltransferase; Digeranylgeranylglyceryl phosphate synthase (DGGGPS) transfers a geranylgeranyl group from geranylgeranyl diphosphate to (S)-3-O-geranylgeranylglyceryl phosphate to form (S)-2,3-di-O-geranylgeranylglyceryl phosphate, as part of the isoprenoid ether lipid biosynthesis. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260124  Cd Length: 270  Bit Score: 54.43  E-value: 1.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514  15 YLVLTKPRVTQLAVFCAVIGMFLAAPGIPDM--QRVLFGTLGIWLLAAAAFAINCLIEQEVDarMLRTARRATARGTISA 92
Cdd:cd13961     2 YLELIRPPNLLMAALAQYLGALFALGPLLSLndLELLLLFLSVFLIAAAGYIINDYFDVEID--RINKPDRPIPSGRISR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514  93 YQVLSLSGLLGGAGMFVLYhmvnpLTMWLTFATFVGYAVI---YTVILKpRTP--QNIVIGGLSGaMPPALGWAAVADSV 167
Cdd:cd13961    80 REALILSILLNALGLILAF-----LLSPLALLIALLNSLLlwlYSHKLK-RTPliGNLLVALLTG-LPFLFGGLAAGNLL 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514 168 PAeAWVLVLIIFIwtpphfwaLALYR-----NHDY---AKAGLPMLPVTHGQQFTRLHILLYSVALLATTLLPYIILMSG 239
Cdd:cd13961   153 LI-ILLLALFAFL--------ITLGReivkdIEDVegdRAEGARTLPIVYGIKKAKKIAALLLLLAILLSPLPYLLGGLG 223

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1337428514 240 VLYLTAALVLGGMFLSYAWRLYREYSDELARSmfrfSILYLALLFGAL 287
Cdd:cd13961   224 ILYLILIIIADLLFLYSAIRLAKSPKDYSKLS----KLLKLAMLLGLL 267
PLN02809 PLN02809
4-hydroxybenzoate nonaprenyltransferase
 38-167 8.27e-03

4-hydroxybenzoate nonaprenyltransferase


Pssm-ID: 178405  Cd Length: 289  Bit Score: 37.36  E-value: 8.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337428514  38 AAPG-IPDMQR-VLFGTlGIWLLAAAAFAINCLIEQEVDARMLRTARRATARGTISAYQVLSLSGLLGGAGMFVLYHMVN 115
Cdd:PLN02809   36 APPGsLPDLKMlALFGC-GALLLRGAGCTINDLLDRDIDKKVERTKLRPIASGALTPFQGVGFLGAQLLLGLGILLQLNN 114

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1337428514 116 pltmwltFATFVGYAVIYTV----ILKPRTPQNIVIGGLSGAMPPALGWAAVADSV 167
Cdd:PLN02809  115 -------YSRILGASSLLLVftypLMKRFTFWPQAFLGLTFNWGALLGWAAVKGSL 163
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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