NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1225349198|ref|WP_093359542|]
View 

MULTISPECIES: DUF2793 domain-containing protein [Alphaproteobacteria]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DUF2793 pfam10983
Protein of unknown function (DUF2793); This is a bacterial family of proteins with unknown ...
 24-109 7.78e-46

Protein of unknown function (DUF2793); This is a bacterial family of proteins with unknown function.


:

Pssm-ID: 431578  Cd Length: 86  Bit Score: 151.23  E-value: 7.78e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1225349198  24 HNEALRLLDGLVQLSVLDRDLTAPPGSPADGDRYIVASGATGEWSGWDLNVALWTDGAWLRLPPRIGWRAWVEDEGLLLV 103
Cdd:pfam10983   1 HNEALRRLDALVQLAVLSRDLTTPPASPAEGDRYIVPAGATGAWAGHAGAIAAWTDGAWRFLTPRAGWRAWVVDEGALLV 80


                  ....*.
gi 1225349198 104 YDGAGW 109
Cdd:pfam10983  81 FDGTAW 86
BclA_C super family cl47267
BclA C-terminal domain; This is the C-terminal domain of BclA (Bacillus collagen-like protein ...
 240-335 2.81e-04

BclA C-terminal domain; This is the C-terminal domain of BclA (Bacillus collagen-like protein of anthracis) which is expressed on spores of Bacillus species. Trimers of the C-terminal domain (CTD) form the tips of the spore's hair-like nap and are the immunodominant target of vertebrate antibodies and drive trimerization. Structure analysis indicate the C-terminal region of the peptide folding into an all-beta structure with a jelly-fold topology, similar to the first human complement C1q, a member of the tumor necrosis factor (TNF)-like family. The C-terminal globular domain has been shown to be located on the exterior of the exosporium, and therefore is critical in determining the immunogenicity of the spore in a mammalian host.


The actual alignment was detected with superfamily member pfam18573:

Pssm-ID: 436587 [Multi-domain]  Cd Length: 127  Bit Score: 40.34  E-value: 2.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1225349198 240 TKIGLNNTDYNDQGAFDAVNNHFVAPVDGTYLfgatLLYKINASATARMRGRLVLNGTTeIRGSLgeisATHVSLATAIW 319
Cdd:pfam18573  17 TPVPLPNNQNLSGITVNGTNTTFTVNEAGRYY----ISYQVNTTAALLVGLRLLVNGTP-VPGSI----ITPALSTSSYS 87

                          90
                  ....*....|....*.
gi 1225349198 320 LQTMVPLTAGDTVELQ 335
Cdd:pfam18573  88 NSVIVTLTAGDTISLQ 103
 
Name Accession Description Interval E-value
DUF2793 pfam10983
Protein of unknown function (DUF2793); This is a bacterial family of proteins with unknown ...
 24-109 7.78e-46

Protein of unknown function (DUF2793); This is a bacterial family of proteins with unknown function.


Pssm-ID: 431578  Cd Length: 86  Bit Score: 151.23  E-value: 7.78e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1225349198  24 HNEALRLLDGLVQLSVLDRDLTAPPGSPADGDRYIVASGATGEWSGWDLNVALWTDGAWLRLPPRIGWRAWVEDEGLLLV 103
Cdd:pfam10983   1 HNEALRRLDALVQLAVLSRDLTTPPASPAEGDRYIVPAGATGAWAGHAGAIAAWTDGAWRFLTPRAGWRAWVVDEGALLV 80


                  ....*.
gi 1225349198 104 YDGAGW 109
Cdd:pfam10983  81 FDGTAW 86
BclA_C pfam18573
BclA C-terminal domain; This is the C-terminal domain of BclA (Bacillus collagen-like protein ...
 240-335 2.81e-04

BclA C-terminal domain; This is the C-terminal domain of BclA (Bacillus collagen-like protein of anthracis) which is expressed on spores of Bacillus species. Trimers of the C-terminal domain (CTD) form the tips of the spore's hair-like nap and are the immunodominant target of vertebrate antibodies and drive trimerization. Structure analysis indicate the C-terminal region of the peptide folding into an all-beta structure with a jelly-fold topology, similar to the first human complement C1q, a member of the tumor necrosis factor (TNF)-like family. The C-terminal globular domain has been shown to be located on the exterior of the exosporium, and therefore is critical in determining the immunogenicity of the spore in a mammalian host.


Pssm-ID: 436587 [Multi-domain]  Cd Length: 127  Bit Score: 40.34  E-value: 2.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1225349198 240 TKIGLNNTDYNDQGAFDAVNNHFVAPVDGTYLfgatLLYKINASATARMRGRLVLNGTTeIRGSLgeisATHVSLATAIW 319
Cdd:pfam18573  17 TPVPLPNNQNLSGITVNGTNTTFTVNEAGRYY----ISYQVNTTAALLVGLRLLVNGTP-VPGSI----ITPALSTSSYS 87

                          90
                  ....*....|....*.
gi 1225349198 320 LQTMVPLTAGDTVELQ 335
Cdd:pfam18573  88 NSVIVTLTAGDTISLQ 103
 
Name Accession Description Interval E-value
DUF2793 pfam10983
Protein of unknown function (DUF2793); This is a bacterial family of proteins with unknown ...
 24-109 7.78e-46

Protein of unknown function (DUF2793); This is a bacterial family of proteins with unknown function.


Pssm-ID: 431578  Cd Length: 86  Bit Score: 151.23  E-value: 7.78e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1225349198  24 HNEALRLLDGLVQLSVLDRDLTAPPGSPADGDRYIVASGATGEWSGWDLNVALWTDGAWLRLPPRIGWRAWVEDEGLLLV 103
Cdd:pfam10983   1 HNEALRRLDALVQLAVLSRDLTTPPASPAEGDRYIVPAGATGAWAGHAGAIAAWTDGAWRFLTPRAGWRAWVVDEGALLV 80


                  ....*.
gi 1225349198 104 YDGAGW 109
Cdd:pfam10983  81 FDGTAW 86
BclA_C pfam18573
BclA C-terminal domain; This is the C-terminal domain of BclA (Bacillus collagen-like protein ...
 240-335 2.81e-04

BclA C-terminal domain; This is the C-terminal domain of BclA (Bacillus collagen-like protein of anthracis) which is expressed on spores of Bacillus species. Trimers of the C-terminal domain (CTD) form the tips of the spore's hair-like nap and are the immunodominant target of vertebrate antibodies and drive trimerization. Structure analysis indicate the C-terminal region of the peptide folding into an all-beta structure with a jelly-fold topology, similar to the first human complement C1q, a member of the tumor necrosis factor (TNF)-like family. The C-terminal globular domain has been shown to be located on the exterior of the exosporium, and therefore is critical in determining the immunogenicity of the spore in a mammalian host.


Pssm-ID: 436587 [Multi-domain]  Cd Length: 127  Bit Score: 40.34  E-value: 2.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1225349198 240 TKIGLNNTDYNDQGAFDAVNNHFVAPVDGTYLfgatLLYKINASATARMRGRLVLNGTTeIRGSLgeisATHVSLATAIW 319
Cdd:pfam18573  17 TPVPLPNNQNLSGITVNGTNTTFTVNEAGRYY----ISYQVNTTAALLVGLRLLVNGTP-VPGSI----ITPALSTSSYS 87

                          90
                  ....*....|....*.
gi 1225349198 320 LQTMVPLTAGDTVELQ 335
Cdd:pfam18573  88 NSVIVTLTAGDTISLQ 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH