NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1224993953|ref|WP_093008760.1|]
View 

IS3 family transposase

Protein Classification

transposase family protein( domain architecture ID 1750059)

transposase family protein might bind to the end of a transposon and catalyze the movement of the transposon to another part of the genome by a cut and paste mechanism or a replicative transposition mechanism

Gene Ontology:  GO:0003677|GO:0006313
PubMed:  11774877

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
transpos_IS3 super family cl41295
IS3 family transposase;
8-362 6.75e-115

IS3 family transposase;


The actual alignment was detected with superfamily member NF033516:

Pssm-ID: 468052 [Multi-domain]  Cd Length: 369  Bit Score: 338.77  E-value: 6.75e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953   8 EKAKIVLEVLSGQRTVAEACRAYGMAESLFYRWQREFLENAHAAF----TSGCAEQEARIRELERLAGQLALELEVPKKS 83
Cdd:NF033516    2 FKLEAVREVLEGGKSVAEVARELGISPSTLYRWRKKYRGGGEAADagrlKELLTPEEEENRRLKRELAELRLENEILKKA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953  84 LGALPAKERRELVKALKGAYPLRLLSRVLGVPRSTLYYRPQDPP----PEEAALRGRLRALAEAWP-RYGYRRLTALLRG 158
Cdd:NF033516   82 RKLLRPAVKYALIDALRGEYSVRRACRVLGVSRSTYYYWRKRPPsrraPDDAELRARIREIFEESRgRYGYRRITALLRR 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953 159 EGVQVGEKRVRSLMREEGLLLPRKGSSPRTTFPGGLPPEGVKNLLP-GLEVTRPHQVWVADLSYVVLGEGVAYLAVVMDL 237
Cdd:NF033516  162 EGIRVNHKRVYRLMRELGLLARRRRKRRPYTTDSGHVHPVAPNLLNrQFTATRPNQVWVTDITYIRTAEGWLYLAVVLDL 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953 238 HTRKILGVALGPRLSQGLALAA-LEMALREGCPE--VHHSDRGVQYTSRAYVERLLGLGVRLSYAGTGRPWENGHAERLI 314
Cdd:NF033516  242 FSREIVGWSVSTSMSAELVLDAlEMAIEWRGKPEglILHSDNGSQYTSKAYREWLKEHGITQSMSRPGNCWDNAVAESFF 321

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1224993953 315 RTIKEEWVALREYRTLAEARASVKAFVlEVYNRKRPHSALDYMTPEAF 362
Cdd:NF033516  322 GTLKRECLYRRRFRTLEEARQAIEEYI-EFYNHERPHSSLGYLTPAEF 368
 
Name Accession Description Interval E-value
transpos_IS3 NF033516
IS3 family transposase;
8-362 6.75e-115

IS3 family transposase;


Pssm-ID: 468052 [Multi-domain]  Cd Length: 369  Bit Score: 338.77  E-value: 6.75e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953   8 EKAKIVLEVLSGQRTVAEACRAYGMAESLFYRWQREFLENAHAAF----TSGCAEQEARIRELERLAGQLALELEVPKKS 83
Cdd:NF033516    2 FKLEAVREVLEGGKSVAEVARELGISPSTLYRWRKKYRGGGEAADagrlKELLTPEEEENRRLKRELAELRLENEILKKA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953  84 LGALPAKERRELVKALKGAYPLRLLSRVLGVPRSTLYYRPQDPP----PEEAALRGRLRALAEAWP-RYGYRRLTALLRG 158
Cdd:NF033516   82 RKLLRPAVKYALIDALRGEYSVRRACRVLGVSRSTYYYWRKRPPsrraPDDAELRARIREIFEESRgRYGYRRITALLRR 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953 159 EGVQVGEKRVRSLMREEGLLLPRKGSSPRTTFPGGLPPEGVKNLLP-GLEVTRPHQVWVADLSYVVLGEGVAYLAVVMDL 237
Cdd:NF033516  162 EGIRVNHKRVYRLMRELGLLARRRRKRRPYTTDSGHVHPVAPNLLNrQFTATRPNQVWVTDITYIRTAEGWLYLAVVLDL 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953 238 HTRKILGVALGPRLSQGLALAA-LEMALREGCPE--VHHSDRGVQYTSRAYVERLLGLGVRLSYAGTGRPWENGHAERLI 314
Cdd:NF033516  242 FSREIVGWSVSTSMSAELVLDAlEMAIEWRGKPEglILHSDNGSQYTSKAYREWLKEHGITQSMSRPGNCWDNAVAESFF 321

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1224993953 315 RTIKEEWVALREYRTLAEARASVKAFVlEVYNRKRPHSALDYMTPEAF 362
Cdd:NF033516  322 GTLKRECLYRRRFRTLEEARQAIEEYI-EFYNHERPHSSLGYLTPAEF 368
Tra5 COG2801
Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];
57-368 1.18e-78

Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442053 [Multi-domain]  Cd Length: 309  Bit Score: 243.91  E-value: 1.18e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953  57 AEQEARIRELERLAGQLALELEVPKKSLGALPAKERRELVKALKGAYPLRLLSRVLGVPRSTLYYRPQdpppEEAALRGR 136
Cdd:COG2801     1 ELAEEEELRKEEELLRRLLLLLRLLLLRRRVLRRVSRRRRRLLRLLRRRRARSRRRRRLRRPRSYRAD----EDAELLER 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953 137 LRALAEAWPRYGYRRLTALLRGEGVQVGEKRVRSLMREEGLLLPRKGSSPRTTFPGGLPPeGVKNLLpgLEVTRPHQVWV 216
Cdd:COG2801    77 IKEIFAESPRYGYRRITAELRREGIAVNRKRVRRLMRELGLQARRRRKKKYTTYSGHGGP-IAPNLL--FTATAPNQVWV 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953 217 ADLSYVVLGEGVAYLAVVMDLHTRKILGVALGPRLSQGLALA---ALEMALREGCPEVHHSDRGVQYTSRAYVERLLGLG 293
Cdd:COG2801   154 TDITYIPTAEGWLYLAAVIDLFSREIVGWSVSDSMDAELVVDaleMAIERRGPPKPLILHSDNGSQYTSKAYQELLKKLG 233

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1224993953 294 VRLSYAGTGRPWENGHAERLIRTIKEEWVALREYRTLAEARASVKAFVlEVYNRKRPHSALDYMTPEAFSESLLK 368
Cdd:COG2801   234 ITQSMSRPGNPQDNAFIESFFGTLKYELLYRRRFESLEEAREAIEEYI-EFYNHERPHSSLGYLTPAEYEKQLAA 307
PHA02517 PHA02517
putative transposase OrfB; Reviewed
 112-359 5.46e-42

putative transposase OrfB; Reviewed


Pssm-ID: 222853 [Multi-domain]  Cd Length: 277  Bit Score: 148.09  E-value: 5.46e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953 112 LGVPRSTLYY---RPQDP------PPEEAALRGR-LRALAEAWPRYGYRRLTALLRGEGVQVGEKRVRSLMREEGLLLPR 181
Cdd:PHA02517    1 LGIAPSTYYRcqqQRHHPdkrrarAQHDDWLKSEiLRVYDENHQVYGVRKVWRQLNREGIRVARCTVGRLMKELGLAGVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953 182 KGSSPRTTfpGGLPPEGVKNLLP-GLEVTRPHQVWVADLSYVVLGEGVAYLAVVMDLHTRKILGVALG----PRLSQGLA 256
Cdd:PHA02517   81 RGKKVRTT--ISRKAVAAPDRVNrQFVATRPNQLWVADFTYVSTWQGWVYVAFIIDVFARRIVGWRVSssmdTDFVLDAL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953 257 LAALEMALREGcPEVHHSDRGVQYTSRAYVERLLGLGVRLSYAGTGRPWENGHAERLIRTIKEEWVALREYRTLAEARAS 336
Cdd:PHA02517  159 EQALWARGRPG-GLIHHSDKGSQYVSLAYTQRLKEAGIRASTGSRGDSYDNAPAESINGLYKAEVIHRVSWKNREEVELA 237

                         250       260
                  ....*....|....*....|...
gi 1224993953 337 VKAFVlEVYNRKRPHSALDYMTP 359
Cdd:PHA02517  238 TLEWV-AWYNNRRLHERLGYTPP 259
rve_3 pfam13683
Integrase core domain;
292-359 2.67e-20

Integrase core domain;


Pssm-ID: 433402 [Multi-domain]  Cd Length: 67  Bit Score: 83.80  E-value: 2.67e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1224993953 292 LGVRLSYAGTGRPWENGHAERLIRTIKEEWVALREYRTLAEARASVKAFVlEVYNRKRPHSALDYMTP 359
Cdd:pfam13683   1 LGIEISYIAPGKPMQNGLVESFNGTLRDECLNEHLFSSLAEARALLAAWR-EDYNTERPHSSLGYRTP 67
transpos_IS481 NF033577
IS481 family transposase; null
 92-359 4.22e-20

IS481 family transposase; null


Pssm-ID: 468094 [Multi-domain]  Cd Length: 283  Bit Score: 89.19  E-value: 4.22e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953  92 RRELVK-ALKGAYPLRLLSRVLGVPRSTLYY------------------RPQDPPPE-EAALRGRLRALAEAWpRYGYRR 151
Cdd:NF033577    2 RLELVRlVLEDGWSVREAARRFGISRKTVYKwlkryraggeeglidrsrRPHRSPRRtSPETEARILALRREL-RLGPRR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953 152 LTALLRGEGVQVGEKRVRSLMREEGLLLPR---KGSSPRTTFpgglppegvknllpglEVTRPHQVWVADLSYVVL--GE 226
Cdd:NF033577   81 IAYELERQGPGVSRSTVHRILRRHGLSRLRaldRKTGKVKRY----------------ERAHPGELWHIDIKKLGRipDV 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953 227 GVAYLAVVMDLHTRKILGVALGPRLSQGLALAALEMALREGCPeVHH--SDRGVQYTSRA-YVERLLG-LGVRLSYAGTG 302
Cdd:NF033577  145 GRLYLHTAIDDHSRFAYAELYPDETAETAADFLRRAFAEHGIP-IRRvlTDNGSEFRSRAhGFELALAeLGIEHRRTRPY 223

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1224993953 303 RPWENGHAERLIRTIKEEWVALREYRTLAEARASVKAFvLEVYNRKRPHSALDYMTP 359
Cdd:NF033577  224 HPQTNGKVERFHRTLKDEFAYARPYESLAELQAALDEW-LHHYNHHRPHSALGGKTP 279
transpos_IS21 NF033546
IS21 family transposase;
109-364 2.20e-03

IS21 family transposase;


Pssm-ID: 468077 [Multi-domain]  Cd Length: 296  Bit Score: 39.50  E-value: 2.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953 109 SRVLGVPRST--------------LYYRPQDPPPEEAALRGRLRALAEAWPRYGYRRLTAL---LRGEGVQVGEKRVRSL 171
Cdd:NF033546   15 ARELGISRNTvrkylrragldeppKYERRPPRPSKLDPFEPYIPDWLEAHLRKPGVTATLLweeLRAEGYPGSYSTVRRY 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953 172 MRE-EGLLLPRKGSSPRTTFPG-------GLPPEGVKNllpglEVTRPHQVWVADLSY-------VVLGEGvayLAVVMD 236
Cdd:NF033546   95 VRRwRAEQGPAKVFVRLEHAPGeqaqvdfGEATVVVTG-----GTGKILHVFVAVLGYsrytyveATPSES---QEDLLD 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953 237 LHTRKILgvALGprlsqglalaalemalreGCPEVHHSD-------RGVQYTSRAYVERLLGL----GVRLSYAGTGRPW 305
Cdd:NF033546  167 GHQRAFE--FFG------------------GVPREIVYDnlktavdKRDRYEEPRLNPRFAAFaahyGFEPRPCRPYRPQ 226

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1224993953 306 ENGHAERLIRTIKEE--WVALREYRTLAEARASVKAFVLEVYNRkRPHSALDYMTPEAFSE 364
Cdd:NF033546  227 EKGKVERAVGYVRRWflRLRGRRFESLAELNAALAEWLAELANQ-RPHGTTGGSPAERFEE 286
 
Name Accession Description Interval E-value
transpos_IS3 NF033516
IS3 family transposase;
8-362 6.75e-115

IS3 family transposase;


Pssm-ID: 468052 [Multi-domain]  Cd Length: 369  Bit Score: 338.77  E-value: 6.75e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953   8 EKAKIVLEVLSGQRTVAEACRAYGMAESLFYRWQREFLENAHAAF----TSGCAEQEARIRELERLAGQLALELEVPKKS 83
Cdd:NF033516    2 FKLEAVREVLEGGKSVAEVARELGISPSTLYRWRKKYRGGGEAADagrlKELLTPEEEENRRLKRELAELRLENEILKKA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953  84 LGALPAKERRELVKALKGAYPLRLLSRVLGVPRSTLYYRPQDPP----PEEAALRGRLRALAEAWP-RYGYRRLTALLRG 158
Cdd:NF033516   82 RKLLRPAVKYALIDALRGEYSVRRACRVLGVSRSTYYYWRKRPPsrraPDDAELRARIREIFEESRgRYGYRRITALLRR 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953 159 EGVQVGEKRVRSLMREEGLLLPRKGSSPRTTFPGGLPPEGVKNLLP-GLEVTRPHQVWVADLSYVVLGEGVAYLAVVMDL 237
Cdd:NF033516  162 EGIRVNHKRVYRLMRELGLLARRRRKRRPYTTDSGHVHPVAPNLLNrQFTATRPNQVWVTDITYIRTAEGWLYLAVVLDL 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953 238 HTRKILGVALGPRLSQGLALAA-LEMALREGCPE--VHHSDRGVQYTSRAYVERLLGLGVRLSYAGTGRPWENGHAERLI 314
Cdd:NF033516  242 FSREIVGWSVSTSMSAELVLDAlEMAIEWRGKPEglILHSDNGSQYTSKAYREWLKEHGITQSMSRPGNCWDNAVAESFF 321

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1224993953 315 RTIKEEWVALREYRTLAEARASVKAFVlEVYNRKRPHSALDYMTPEAF 362
Cdd:NF033516  322 GTLKRECLYRRRFRTLEEARQAIEEYI-EFYNHERPHSSLGYLTPAEF 368
Tra5 COG2801
Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];
57-368 1.18e-78

Transposase InsO and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442053 [Multi-domain]  Cd Length: 309  Bit Score: 243.91  E-value: 1.18e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953  57 AEQEARIRELERLAGQLALELEVPKKSLGALPAKERRELVKALKGAYPLRLLSRVLGVPRSTLYYRPQdpppEEAALRGR 136
Cdd:COG2801     1 ELAEEEELRKEEELLRRLLLLLRLLLLRRRVLRRVSRRRRRLLRLLRRRRARSRRRRRLRRPRSYRAD----EDAELLER 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953 137 LRALAEAWPRYGYRRLTALLRGEGVQVGEKRVRSLMREEGLLLPRKGSSPRTTFPGGLPPeGVKNLLpgLEVTRPHQVWV 216
Cdd:COG2801    77 IKEIFAESPRYGYRRITAELRREGIAVNRKRVRRLMRELGLQARRRRKKKYTTYSGHGGP-IAPNLL--FTATAPNQVWV 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953 217 ADLSYVVLGEGVAYLAVVMDLHTRKILGVALGPRLSQGLALA---ALEMALREGCPEVHHSDRGVQYTSRAYVERLLGLG 293
Cdd:COG2801   154 TDITYIPTAEGWLYLAAVIDLFSREIVGWSVSDSMDAELVVDaleMAIERRGPPKPLILHSDNGSQYTSKAYQELLKKLG 233

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1224993953 294 VRLSYAGTGRPWENGHAERLIRTIKEEWVALREYRTLAEARASVKAFVlEVYNRKRPHSALDYMTPEAFSESLLK 368
Cdd:COG2801   234 ITQSMSRPGNPQDNAFIESFFGTLKYELLYRRRFESLEEAREAIEEYI-EFYNHERPHSSLGYLTPAEYEKQLAA 307
PHA02517 PHA02517
putative transposase OrfB; Reviewed
 112-359 5.46e-42

putative transposase OrfB; Reviewed


Pssm-ID: 222853 [Multi-domain]  Cd Length: 277  Bit Score: 148.09  E-value: 5.46e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953 112 LGVPRSTLYY---RPQDP------PPEEAALRGR-LRALAEAWPRYGYRRLTALLRGEGVQVGEKRVRSLMREEGLLLPR 181
Cdd:PHA02517    1 LGIAPSTYYRcqqQRHHPdkrrarAQHDDWLKSEiLRVYDENHQVYGVRKVWRQLNREGIRVARCTVGRLMKELGLAGVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953 182 KGSSPRTTfpGGLPPEGVKNLLP-GLEVTRPHQVWVADLSYVVLGEGVAYLAVVMDLHTRKILGVALG----PRLSQGLA 256
Cdd:PHA02517   81 RGKKVRTT--ISRKAVAAPDRVNrQFVATRPNQLWVADFTYVSTWQGWVYVAFIIDVFARRIVGWRVSssmdTDFVLDAL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953 257 LAALEMALREGcPEVHHSDRGVQYTSRAYVERLLGLGVRLSYAGTGRPWENGHAERLIRTIKEEWVALREYRTLAEARAS 336
Cdd:PHA02517  159 EQALWARGRPG-GLIHHSDKGSQYVSLAYTQRLKEAGIRASTGSRGDSYDNAPAESINGLYKAEVIHRVSWKNREEVELA 237

                         250       260
                  ....*....|....*....|...
gi 1224993953 337 VKAFVlEVYNRKRPHSALDYMTP 359
Cdd:PHA02517  238 TLEWV-AWYNNRRLHERLGYTPP 259
rve_3 pfam13683
Integrase core domain;
292-359 2.67e-20

Integrase core domain;


Pssm-ID: 433402 [Multi-domain]  Cd Length: 67  Bit Score: 83.80  E-value: 2.67e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1224993953 292 LGVRLSYAGTGRPWENGHAERLIRTIKEEWVALREYRTLAEARASVKAFVlEVYNRKRPHSALDYMTP 359
Cdd:pfam13683   1 LGIEISYIAPGKPMQNGLVESFNGTLRDECLNEHLFSSLAEARALLAAWR-EDYNTERPHSSLGYRTP 67
transpos_IS481 NF033577
IS481 family transposase; null
 92-359 4.22e-20

IS481 family transposase; null


Pssm-ID: 468094 [Multi-domain]  Cd Length: 283  Bit Score: 89.19  E-value: 4.22e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953  92 RRELVK-ALKGAYPLRLLSRVLGVPRSTLYY------------------RPQDPPPE-EAALRGRLRALAEAWpRYGYRR 151
Cdd:NF033577    2 RLELVRlVLEDGWSVREAARRFGISRKTVYKwlkryraggeeglidrsrRPHRSPRRtSPETEARILALRREL-RLGPRR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953 152 LTALLRGEGVQVGEKRVRSLMREEGLLLPR---KGSSPRTTFpgglppegvknllpglEVTRPHQVWVADLSYVVL--GE 226
Cdd:NF033577   81 IAYELERQGPGVSRSTVHRILRRHGLSRLRaldRKTGKVKRY----------------ERAHPGELWHIDIKKLGRipDV 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953 227 GVAYLAVVMDLHTRKILGVALGPRLSQGLALAALEMALREGCPeVHH--SDRGVQYTSRA-YVERLLG-LGVRLSYAGTG 302
Cdd:NF033577  145 GRLYLHTAIDDHSRFAYAELYPDETAETAADFLRRAFAEHGIP-IRRvlTDNGSEFRSRAhGFELALAeLGIEHRRTRPY 223

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1224993953 303 RPWENGHAERLIRTIKEEWVALREYRTLAEARASVKAFvLEVYNRKRPHSALDYMTP 359
Cdd:NF033577  224 HPQTNGKVERFHRTLKDEFAYARPYESLAELQAALDEW-LHHYNHHRPHSALGGKTP 279
InsE COG2963
Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];
1-87 9.54e-17

Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442203 [Multi-domain]  Cd Length: 93  Bit Score: 74.58  E-value: 9.54e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953   1 MRRWSAKEKAKIVLEVLSGQRTVAEACRAYGMAESLFYRWQREFLENAHAAF--TSGCAEQEARIRELERLAGQLALELE 78
Cdd:COG2963     5 RRRYSPEFKAEAVRLVLEGGASVAEVARELGISPSTLYRWVRQYREGGLGGFpgDGRTTPEQAEIRRLRKELRRLEMEND 84


                  ....*....
gi 1224993953  79 VPKKSLGAL 87
Cdd:COG2963    85 ILKKAAALL 93
rve pfam00665
Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into ...
 211-304 3.88e-16

Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.


Pssm-ID: 459897 [Multi-domain]  Cd Length: 98  Bit Score: 73.12  E-value: 3.88e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953 211 PHQVWVADLSYV--VLGEGVAYLAVVMDLHTRKILGVALG--PRLSQGLALAALEMALREGCPEVHHSDRGVQYTSRAYV 286
Cdd:pfam00665   1 PNQLWQGDFTYIriPGGGGKLYLLVIVDDFSREILAWALSseMDAELVLDALERAIAFRGGVPLIIHSDNGSEYTSKAFR 80

                          90
                  ....*....|....*...
gi 1224993953 287 ERLLGLGVRLSYAGTGRP 304
Cdd:pfam00665  81 EFLKDLGIKPSFSRPGNP 98
HTH_21 pfam13276
HTH-like domain; This domain contains a predicted helix-turn-helix suggesting a DNA-binding ...
 128-183 5.05e-09

HTH-like domain; This domain contains a predicted helix-turn-helix suggesting a DNA-binding function.


Pssm-ID: 463824 [Multi-domain]  Cd Length: 60  Bit Score: 51.80  E-value: 5.05e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1224993953 128 PEEAALRGRLRALAEAW-PRYGYRRLTALLRGEG-VQVGEKRVRSLMREEGLLLPRKG 183
Cdd:pfam13276   1 ELEDELLEAIREIFEESrGTYGYRRITAELRREGgIRVNRKRVARLMRELGLRARRRR 58
HTH_Tnp_1 pfam01527
Transposase; Transposase proteins are necessary for efficient DNA transposition. This family ...
 2-69 1.50e-07

Transposase; Transposase proteins are necessary for efficient DNA transposition. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.


Pssm-ID: 426308 [Multi-domain]  Cd Length: 75  Bit Score: 48.12  E-value: 1.50e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1224993953   2 RRWSAKEKAKIVLEVLSGQRTVAEACRAYGMAESLFYRWQREFLEN-AHAAFTSGCAEQEARIRELERL 69
Cdd:pfam01527   5 RRFSEEFKLRAVKEVLEPGRTVKEVARRHGVSPNTLYQWRRQYEGGmGASPARPRLTALEEENRRLKRE 73
PRK09409 PRK09409
IS2 transposase TnpB; Reviewed
 145-362 7.74e-07

IS2 transposase TnpB; Reviewed


Pssm-ID: 181829 [Multi-domain]  Cd Length: 301  Bit Score: 50.10  E-value: 7.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953 145 PRYGYRRLTALLRGEG-----VQVGEKRVRSLMREEGLLLPRKGSSPrttfPGGLPPEGvknllpGLEVTRPHQVWVADL 219
Cdd:PRK09409   64 PTYGYRRVWALLRRQAeldgmPAINAKRVYRIMRQNALLLERKPAVP----PSKRAHTG------RVAVKESNQRWCSDG 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953 220 SYVVLGEGVAY-LAVVMDLHTRKIL--GVALGPRLSQGLALAALEMALRE------GCPEVHHSDRGVQYTSRAYVERLL 290
Cdd:PRK09409  134 FEFCCDNGERLrVTFALDCCDREALhwAVTTGGFNSETVQDVMLGAVERRfgndlpSSPVEWLTDNGSCYRANETRQFAR 213

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1224993953 291 GLGVRLSYAGTGRPWENGHAERLIRTIKEEWVALR-EYRTLAEARASVKAFvlEVYNRKRPHSALDYMTPEAF 362
Cdd:PRK09409  214 MLGLEPKNTAVRSPESNGIAESFVKTIKRDYISIMpKPDGLTAAKNLAEAF--EHYNEWHPHSALGYRSPREY 284
PRK14702 PRK14702
insertion element IS2 transposase InsD; Provisional
 145-362 1.38e-06

insertion element IS2 transposase InsD; Provisional


Pssm-ID: 237792 [Multi-domain]  Cd Length: 262  Bit Score: 49.35  E-value: 1.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953 145 PRYGYRRLTALLRGEG-----VQVGEKRVRSLMREEGLLLPRKGSSPrttfPGGLPPEGvknllpGLEVTRPHQVWVADL 219
Cdd:PRK14702   25 PTYGYRRVWALLRRQAeldgmPAINAKRVYRLMRQNALLLERKPAVP----PSKRAHTG------RVAVKESNQRWCSDG 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953 220 SYVVLGEGVAY-LAVVMDLHTRKIL--GVALGPRLSQGLALAALEMALRE------GCPEVHHSDRGVQYTSRAYVERLL 290
Cdd:PRK14702   95 FEFCCDNGERLrVTFALDCCDREALhwAVTTGGFNSETVQDVMLGAVERRfgndlpSSPVEWLTDNGSCYRANETRQFAR 174

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1224993953 291 GLGVRLSYAGTGRPWENGHAERLIRTIKEEWVALR-EYRTLAEARASVKAFvlEVYNRKRPHSALDYMTPEAF 362
Cdd:PRK14702  175 MLGLEPKNTAVRSPESNGIAESFVKTIKRDYISIMpKPDGLTAAKNLAEAF--EHYNEWHPHSALGYRSPREY 245
Tra8 COG2826
Transposase and inactivated derivatives, IS30 family [Mobilome: prophages, transposons];
275-368 3.06e-05

Transposase and inactivated derivatives, IS30 family [Mobilome: prophages, transposons];


Pssm-ID: 442074 [Multi-domain]  Cd Length: 325  Bit Score: 45.26  E-value: 3.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953 275 DRGVQYTSRAYVERLLGLGVRLSYAGTgrPWENGHAERLIRTIKEEWValreYRT-LAEARASVKAFVLEVYNRkRPHSA 353
Cdd:COG2826   235 DNGKEFADHKEIEAALGIKVYFADPYS--PWQRGTNENTNGLLRQYFP----KGTdFSTVTQEELDAIADRLNN-RPRKC 307

                          90
                  ....*....|....*.
gi 1224993953 354 LDYMTP-EAFSESLLK 368
Cdd:COG2826   308 LGYKTPaEVFAEELAA 323
PRK09413 PRK09413
IS2 repressor TnpA; Reviewed
 2-84 5.31e-04

IS2 repressor TnpA; Reviewed


Pssm-ID: 181833  Cd Length: 121  Bit Score: 39.40  E-value: 5.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953   2 RRWSAKEKAKIVLEVLSGQRTVAEACRAYGMAESLFYRWQREFLENAHAAFTSG--------CAEQEARIRELERLAGQL 73
Cdd:PRK09413   11 RRRTTQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGeqvvpaseLAAAMKQIKELQRLLGKK 90

                          90
                  ....*....|.
gi 1224993953  74 ALELEVPKKSL 84
Cdd:PRK09413   91 TMENELLKEAV 101
DUF1153 pfam06627
Protein of unknown function (DUF1153); This family consists of several short, hypothetical ...
 2-42 1.01e-03

Protein of unknown function (DUF1153); This family consists of several short, hypothetical bacterial proteins of unknown function.


Pssm-ID: 429042  Cd Length: 87  Bit Score: 37.64  E-value: 1.01e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1224993953   2 RRWSAKEKAKIVLEVLSGQRTVAEACRAYGMAESLFYRWQR 42
Cdd:pfam06627  28 RRWVARRKAEVVAAVRGGLLTLDEACERYGLSEEEFASWQR 68
transpos_IS21 NF033546
IS21 family transposase;
109-364 2.20e-03

IS21 family transposase;


Pssm-ID: 468077 [Multi-domain]  Cd Length: 296  Bit Score: 39.50  E-value: 2.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953 109 SRVLGVPRST--------------LYYRPQDPPPEEAALRGRLRALAEAWPRYGYRRLTAL---LRGEGVQVGEKRVRSL 171
Cdd:NF033546   15 ARELGISRNTvrkylrragldeppKYERRPPRPSKLDPFEPYIPDWLEAHLRKPGVTATLLweeLRAEGYPGSYSTVRRY 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953 172 MRE-EGLLLPRKGSSPRTTFPG-------GLPPEGVKNllpglEVTRPHQVWVADLSY-------VVLGEGvayLAVVMD 236
Cdd:NF033546   95 VRRwRAEQGPAKVFVRLEHAPGeqaqvdfGEATVVVTG-----GTGKILHVFVAVLGYsrytyveATPSES---QEDLLD 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1224993953 237 LHTRKILgvALGprlsqglalaalemalreGCPEVHHSD-------RGVQYTSRAYVERLLGL----GVRLSYAGTGRPW 305
Cdd:NF033546  167 GHQRAFE--FFG------------------GVPREIVYDnlktavdKRDRYEEPRLNPRFAAFaahyGFEPRPCRPYRPQ 226

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1224993953 306 ENGHAERLIRTIKEE--WVALREYRTLAEARASVKAFVLEVYNRkRPHSALDYMTPEAFSE 364
Cdd:NF033546  227 EKGKVERAVGYVRRWflRLRGRRFESLAELNAALAEWLAELANQ-RPHGTTGGSPAERFEE 286
HTH_28 pfam13518
Helix-turn-helix domain; This helix-turn-helix domain is often found in transposases and is ...
 8-46 2.23e-03

Helix-turn-helix domain; This helix-turn-helix domain is often found in transposases and is likely to be DNA-binding.


Pssm-ID: 463908 [Multi-domain]  Cd Length: 52  Bit Score: 35.65  E-value: 2.23e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1224993953   8 EKAKIVLEVLSGqRTVAEACRAYGMAESLFYRWQREFLE 46
Cdd:pfam13518   1 ERLKIVLLALEG-ESIKEAARLFGISRSTVYRWIRRYRE 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH