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Conserved domains on  [gi|1169125909|ref|WP_080467930|]
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hypothetical protein, partial [Bacillus cereus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PoNe_LXG-like cd20729
Polymorphic Nuclease effector (PoNe) co-occurring with N-terminal LXG domains; The DNase toxin ...
 1-139 2.37e-77

Polymorphic Nuclease effector (PoNe) co-occurring with N-terminal LXG domains; The DNase toxin domain called PoNe (Polymorphic Nuclease effector) belongs to a diverse superfamily of PD-(D/E)xK phosphodiesterases, and is associated with several toxin delivery systems including type V, type VI, and type VII. PoNe toxicity is antagonized by cognate immunity proteins (PoNi) containing DUF1911 and DUF1910 domains. This subfamily contains some members that contain LXG domains in the N-terminal region. This group of polymorphic toxin proteins in bacteria are predicted to be associated with type VII secretion pathways to mediate export of bacterial toxins.


:

Pssm-ID: 410638  Cd Length: 139  Bit Score: 225.75  E-value: 2.37e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169125909   1 QKGNYGEIKSSDNLLNNQSLKEAGFELKPVGKSAPSGINDKIVKGIDGLYENANAESKIKYVIDEAKFGSSQLGKTKDGR 80
Cdd:cd20729     1 QKGNFGEIKSSDNLLNNQSLKEKGYDLKRVGRSAPSSLDDKIVKGIDGIYENENPESKIKYVIDEAKFGSSQLGKTKDGK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1169125909  81 QMSNDWLNGAKTRKSRILKAVDGDMKLSIKITNALKKGEVERVLSKVDSTGNVKTYRID 139
Cdd:cd20729    81 QMSDDWLKGSETGKSRILKAVDGDEELAEKIKEALKNGQVERVLSKVDSDGNVKTYRLD 139
 
Name Accession Description Interval E-value
PoNe_LXG-like cd20729
Polymorphic Nuclease effector (PoNe) co-occurring with N-terminal LXG domains; The DNase toxin ...
 1-139 2.37e-77

Polymorphic Nuclease effector (PoNe) co-occurring with N-terminal LXG domains; The DNase toxin domain called PoNe (Polymorphic Nuclease effector) belongs to a diverse superfamily of PD-(D/E)xK phosphodiesterases, and is associated with several toxin delivery systems including type V, type VI, and type VII. PoNe toxicity is antagonized by cognate immunity proteins (PoNi) containing DUF1911 and DUF1910 domains. This subfamily contains some members that contain LXG domains in the N-terminal region. This group of polymorphic toxin proteins in bacteria are predicted to be associated with type VII secretion pathways to mediate export of bacterial toxins.


Pssm-ID: 410638  Cd Length: 139  Bit Score: 225.75  E-value: 2.37e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169125909   1 QKGNYGEIKSSDNLLNNQSLKEAGFELKPVGKSAPSGINDKIVKGIDGLYENANAESKIKYVIDEAKFGSSQLGKTKDGR 80
Cdd:cd20729     1 QKGNFGEIKSSDNLLNNQSLKEKGYDLKRVGRSAPSSLDDKIVKGIDGIYENENPESKIKYVIDEAKFGSSQLGKTKDGK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1169125909  81 QMSNDWLNGAKTRKSRILKAVDGDMKLSIKITNALKKGEVERVLSKVDSTGNVKTYRID 139
Cdd:cd20729    81 QMSDDWLKGSETGKSRILKAVDGDEELAEKIKEALKNGQVERVLSKVDSDGNVKTYRLD 139
 
Name Accession Description Interval E-value
PoNe_LXG-like cd20729
Polymorphic Nuclease effector (PoNe) co-occurring with N-terminal LXG domains; The DNase toxin ...
 1-139 2.37e-77

Polymorphic Nuclease effector (PoNe) co-occurring with N-terminal LXG domains; The DNase toxin domain called PoNe (Polymorphic Nuclease effector) belongs to a diverse superfamily of PD-(D/E)xK phosphodiesterases, and is associated with several toxin delivery systems including type V, type VI, and type VII. PoNe toxicity is antagonized by cognate immunity proteins (PoNi) containing DUF1911 and DUF1910 domains. This subfamily contains some members that contain LXG domains in the N-terminal region. This group of polymorphic toxin proteins in bacteria are predicted to be associated with type VII secretion pathways to mediate export of bacterial toxins.


Pssm-ID: 410638  Cd Length: 139  Bit Score: 225.75  E-value: 2.37e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169125909   1 QKGNYGEIKSSDNLLNNQSLKEAGFELKPVGKSAPSGINDKIVKGIDGLYENANAESKIKYVIDEAKFGSSQLGKTKDGR 80
Cdd:cd20729     1 QKGNFGEIKSSDNLLNNQSLKEKGYDLKRVGRSAPSSLDDKIVKGIDGIYENENPESKIKYVIDEAKFGSSQLGKTKDGK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1169125909  81 QMSNDWLNGAKTRKSRILKAVDGDMKLSIKITNALKKGEVERVLSKVDSTGNVKTYRID 139
Cdd:cd20729    81 QMSDDWLKGSETGKSRILKAVDGDEELAEKIKEALKNGQVERVLSKVDSDGNVKTYRLD 139
PoNe_LXG_HINT-like cd20740
Polymorphic Nuclease effector (PoNe) domain co-occurring with N-terminal LXG or pre-toxin HINT ...
 1-97 2.47e-25

Polymorphic Nuclease effector (PoNe) domain co-occurring with N-terminal LXG or pre-toxin HINT domains; The DNase toxin domain called PoNe (Polymorphic Nuclease effector) belongs to a diverse superfamily of PD-(D/E)xK phosphodiesterases, and is associated with several toxin delivery systems including type V, type VI, and type VII. PoNe toxicity is antagonized by cognate immunity proteins (PoNi) containing DUF1911 and DUF1910 domains. This subfamily contains members with PoNe domains that co-occur with N-terminal domains such as HINT or LXG domains. The pre-toxin HINT domain, a member of the HINT superfamily of proteases, is usually found N-terminal to the toxin module in polymorphic toxin systems; the HINT domain is predicted to function in releasing the toxin domain by autoproteolysis. The LXG domains that are present in the N-terminal region of a group of polymorphic toxin proteins in bacteria and predicted to use a Type VII secretion pathway to mediate export of bacterial toxins.


Pssm-ID: 410649  Cd Length: 96  Bit Score: 92.38  E-value: 2.47e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169125909   1 QKGNYGEIKSSDNLLNNqslkeaGFELkpVGKSAPSGINDKIVKGIDGLYENANAESKikYVIDEAKFGSSQLGK-TKDG 79
Cdd:cd20740     1 QKGNYGEMKMDVHYESQ------GYER--ISDGRVTSLDDKIHKGIDGVYENSTPPPK--YIIAEAKYGSSQLGNtTKDG 70

                          90
                  ....*....|....*...
gi 1169125909  80 RQMSNDWLNGAKTRKSRI 97
Cdd:cd20740    71 PQMSDDWILGRLRLEKAV 88
PoNe_FilH-like cd20730
Polymorphic Nuclease effector (PoNe) co-occurring with filamentous hemagglutinin N-terminal ...
 44-142 1.14e-20

Polymorphic Nuclease effector (PoNe) co-occurring with filamentous hemagglutinin N-terminal domain repeats; The DNase toxin domain called PoNe (Polymorphic Nuclease effector) belongs to a diverse superfamily of PD-(D/E)xK phosphodiesterases, and is associated with several toxin delivery systems including type V, type VI, and type VII. PoNe toxicity is antagonized by cognate immunity proteins (PoNi) containing DUF1911 and DUF1910 domains. This subfamily contains proteins with PoNe domains that typically co-occur with N-terminal hemagglutinin repeats and/or a hemagglutination activity domain.


Pssm-ID: 410639  Cd Length: 133  Bit Score: 81.63  E-value: 1.14e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169125909  44 KGIDGLYEnANaESKIKYVIDEAKFGSSQLGKTKDGRQMSNDWLNGAKTRKSRILKAVDGDMKLSIkITNALKKGEVERV 123
Cdd:cd20730    33 NGIDDLYK-VN-RPDVDYVVIEYKFGSSKLKTTKDGLQMSDSWLTGANTNSNRILEAVGGDNAAAV-IRDALRAGRVEKW 109

                          90
                  ....*....|....*....
gi 1169125909 124 LSKVDSTGNVKTYRIDAKG 142
Cdd:cd20730   110 VVHTDPFGSVTVGVLDKLG 128
PoNe_PAAR-like cd20733
Polymorphic Nuclease effector (PoNe) co-occurring with an N-terminal PAAR domain; The DNase ...
 1-139 1.33e-20

Polymorphic Nuclease effector (PoNe) co-occurring with an N-terminal PAAR domain; The DNase toxin domain called PoNe (Polymorphic Nuclease effector) belongs to a diverse superfamily of PD-(D/E)xK phosphodiesterases, and is associated with several toxin delivery systems including type V, type VI, and type VII. PoNe toxicity is antagonized by cognate immunity proteins (PoNi) containing DUF1911 and DUF1910 domains. This subfamily contain members with PoNe domains that typically co-occur with N-terminal domains such as proline-alanine-alanine-arginine (PAAR) repeat domains that form a sharp conical extension on VgrG spikes, which is a trimeric protein complex of the bacterial type VI secretion system (T6SS).


Pssm-ID: 410642  Cd Length: 125  Bit Score: 81.21  E-value: 1.33e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169125909   1 QKGNYGEIKSsdnllnNQSLKEAGFElkPVGKS-APSGINDK-IVKGIDGLYENANAesKIKYVIDEAKFGSSQLGK--T 76
Cdd:cd20733     1 RKGAYGEYIA------DQLMLEKGFE--PLGKTdGQYRLEDKpGGRGIDGVYKNPNP--PPDYVITETKYRTAKLGKglT 70

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1169125909  77 KDGRQMSNDWLngaktrKSRILKAVDGdmKLSIKITNALKKGEVERVLSKVDSTGNVKTYRID 139
Cdd:cd20733    71 DSGKQMSDAWI------DKRLDKAVGK--EKADKIILAMDDGGVEKWLLRVDEDGVVIITKLD 125
PoNe_DUF4280 cd20738
Polymorphic Nuclease effector (PoNe) co-occurring with an N-terminal DUF4280 domain; The DNase ...
 1-140 3.21e-18

Polymorphic Nuclease effector (PoNe) co-occurring with an N-terminal DUF4280 domain; The DNase toxin domain called PoNe (Polymorphic Nuclease effector) belongs to a diverse superfamily of PD-(D/E)xK phosphodiesterases, and is associated with several toxin delivery systems including type V, type VI, and type VII. PoNe toxicity is antagonized by cognate immunity proteins (PoNi) containing DUF1911 and DUF1910 domains. This subfamily contains proteins with PoNe domains that typically co-occur with an N-terminal domain of unknown function (DUF4280), which has a single completely conserved residue C that may be functionally important.


Pssm-ID: 410647  Cd Length: 127  Bit Score: 75.09  E-value: 3.21e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169125909   1 QKGNYGEIKSsdnllnNQSLKEAGFElkPVGKSAPS-GINDKIVKGIDGLYENANAeskikYVIDEAKFGSSQLGKTKD- 78
Cdd:cd20738     4 RKGNYGEMKD------DVYYRQRGYR--DIRKEHPTmDIDKPTASGIDGAYEKPGG-----YVITDAKYNTAKLSKTLAd 70

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1169125909  79 -GRQMSNDWLNgaktrkSRILKAVDGDMKLSIKITNALKKGEVERVLSKVDSTGNVKTYRIDA 140
Cdd:cd20738    71 gTRQMSDKWVE------NHLDNGAGKEKADEARMARANDNGSLQREVTHVDKNGSMRSIPLDD 127
PoNe cd20702
Polymorphic Nuclease effector (PoNe) domain is a deoxyribonuclease; This family contains the ...
 2-87 8.08e-13

Polymorphic Nuclease effector (PoNe) domain is a deoxyribonuclease; This family contains the DNase toxin domain called PoNe (Polymorphic Nuclease effector), which belongs to a diverse superfamily of PD-(D/E)xK phosphodiesterases, and is associated with several toxin delivery systems including type V, type VI, and type VII. PoNe toxicity is antagonized by cognate immunity proteins (PoNi) containing DUF1911 and DUF1910 domains. The PoNe domain co-occurs with a variety of N-terminal domains such as filamentous hemagglutinin, nuclease, HINT, DUFs, PAAR, RHS repeat, or LXG domains. Some members of this family also co-occur with the FIX (Found in type sIX effector) domain of unknown function, as identified by Jana et al., who have also identified this PoNe domain.


Pssm-ID: 410637  Cd Length: 77  Bit Score: 59.69  E-value: 8.08e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169125909   2 KGNYGEIKSsdnllnNQSLKEAGFELKPvgksapSGINDKIVKGIDGLYENANAESkikYVIDEAKFGSSQL------GK 75
Cdd:cd20702     1 KGELGELAA------DLYLKSQGYTKLI------GGSKGGGGNGIDGVYKDPKGPE---YIIVEAKFGSASLkggvslGT 65

                          90
                  ....*....|..
gi 1169125909  76 TKDGRQMSNDWL 87
Cdd:cd20702    66 TKSGRQMSDTWI 77
PoNe_RHS-like cd20734
Polymorphic Nuclease effector (PoNe) domain co-occurring with RHS repeat-associated core ...
 1-89 5.12e-11

Polymorphic Nuclease effector (PoNe) domain co-occurring with RHS repeat-associated core domain; The DNase toxin domain called PoNe (Polymorphic Nuclease effector) belongs to a diverse superfamily of PD-(D/E)xK phosphodiesterases, and is associated with several toxin delivery systems including type V, type VI, and type VII. PoNe toxicity is antagonized by cognate immunity proteins (PoNi) containing DUF1911 and DUF1910 domains. This subfamily contains proteins with PoNe domains typically co-occurring with N-terminal domains such as RHS repeat-associated core domains, which may contain FG-GAP, RHS or YD repeats, and are found in secreted bacterial insecticidal toxins.


Pssm-ID: 410643  Cd Length: 90  Bit Score: 55.33  E-value: 5.12e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169125909   1 QKGNYGEikssdnLLNNQSLKEAGFELKPvgkSAPSGINdkivkGIDGLYENANAESKIKYV-IDEAKFGSSQLGKTKDG 79
Cdd:cd20734     3 IKGNLGE------SLMDIYLKRAGYQKLP---GKVGGNN-----GIDGLYVKYDKDGNIVDIlIVESKFGTSQLGRTGMG 68

                          90
                  ....*....|
gi 1169125909  80 RQMSNDWLNG 89
Cdd:cd20734    69 KQMSQEWIKA 78
PoNe_HINT_TF-like cd20741
Polymorphic Nuclease effector (PoNe) domain co-occurring with N-terminal domains such as HINT ...
 1-86 5.96e-09

Polymorphic Nuclease effector (PoNe) domain co-occurring with N-terminal domains such as HINT or TANFOR; The DNase toxin domain called PoNe (Polymorphic Nuclease effector) belongs to a diverse superfamily of PD-(D/E)xK phosphodiesterases, and is associated with several toxin delivery systems including type V, type VI, and type VII. PoNe toxicity is antagonized by cognate immunity proteins (PoNi) containing DUF1911 and DUF1910 domains. This subfamily contains proteins with PoNe domains that typically co-occur with N-terminal domains such as a TANFOR domain which contains uncharacterized single or repeat domains that co-occur with fibronectin type III domains, or a pre-toxin HINT domain, a member of the HINT superfamily of proteases usually found N-terminal to the toxin module in polymorphic toxin systems; the HINT domain is predicted to function in releasing the toxin domain by autoproteolysis.


Pssm-ID: 410650  Cd Length: 77  Bit Score: 49.67  E-value: 5.96e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169125909   1 QKGNYGEIKSsdnllnNQSLKEAGFELKPVGKSApsgINDKIVKGIDGLYENANAEskiKYVIDEAKFGSSQL--GKTKD 78
Cdd:cd20741     1 RKGNFGEMAT------DVDLFEKGYKPLHTRIDN---IDAPGHQGIDGVFKKPGTG---KYFIVESKYSGTALlnTLTGG 68


                  ....*...
gi 1169125909  79 GRQMSNDW 86
Cdd:cd20741    69 GRQMSDDW 76
PoNe_HINT cd20737
Polymorphic Nuclease effector (PoNe) domain co-occurring with N-terminal domains such as the ...
 2-89 1.14e-06

Polymorphic Nuclease effector (PoNe) domain co-occurring with N-terminal domains such as the HINT domain; The DNase toxin domain called PoNe (Polymorphic Nuclease effector) belongs to a diverse superfamily of PD-(D/E)xK phosphodiesterases, and is associated with several toxin delivery systems including type V, type VI, and type VII. PoNe toxicity is antagonized by cognate immunity proteins (PoNi) containing DUF1911 and DUF1910 domains. This subfamily contains proteins with PoNe domains that typically co-occur with a pre-toxin HINT domain, a member of the HINT superfamily of proteases usually found N-terminal to the toxin module in polymorphic toxin systems; the HINT domain is predicted to function in releasing the toxin domain by autoproteolysis.


Pssm-ID: 410646  Cd Length: 91  Bit Score: 44.35  E-value: 1.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169125909   2 KGNYGEIKSsdnllnNQSLKEAGFE-----LKPVGKSAPSGINDKIVKGIDGLYENANAeskiKYVIDEAK-FGSSQ--- 72
Cdd:cd20737     1 KGFVGELKA------AQILEERGYEplggtLDPRGSPDDAEAKWKGQKGIDGIYRDGDG----KYVIVESKaTGGGKpad 70

                          90       100
                  ....*....|....*....|
gi 1169125909  73 ---LGKTKDGRQMSNDWLNG 89
Cdd:cd20737    71 pklLTTTKGGRQMSEEWIER 90
PoNe_RHS-like cd20735
Polymorphic Nuclease effector (PoNe) domain co-occurring with N-terminal domains such as RHS ...
 45-118 1.93e-05

Polymorphic Nuclease effector (PoNe) domain co-occurring with N-terminal domains such as RHS repeats; The DNase toxin domain called PoNe (Polymorphic Nuclease effector) belongs to a diverse superfamily of PD-(D/E)xK phosphodiesterases, and is associated with several toxin delivery systems including type V, type VI, and type VII. PoNe toxicity is antagonized by cognate immunity proteins (PoNi) containing DUF1911 and DUF1910 domains. This subfamily contains proteins with PoNe domains that typically co-occur with uncharacterized N-terminal RHS repeat domains.


Pssm-ID: 410644 [Multi-domain]  Cd Length: 111  Bit Score: 41.23  E-value: 1.93e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1169125909  45 GIDGLYENANAESKIK-YVIDEAKFGSSQLGKTK-DGRQMSNDWLngaktrKSRILKAVDGDMKLSIKITNALKKG 118
Cdd:cd20735    39 GIDQVWVKRNNDGTIKeYLIVEAKGPGATLGQTPtKGTQMSQRWV------ENNLKEMENAGAVLGRELLDALKLG 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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