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Conserved domains on  [gi|1154824144|ref|WP_078737545|]
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acetate kinase [Porphyromonas circumdentaria]

Protein Classification

acetate kinase( domain architecture ID 10011301)

acetate kinase catalyzes the production of acetyl-CoA by phosphorylating acetate in the presence of ATP; may act on propionate and/or other substrates as well

CATH:  3.30.420.40
EC:  2.7.2.1
Gene Ontology:  GO:0008776|GO:0016310|GO:0000287|GO:0006085|GO:0005524
PubMed:  16678422

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 1-399 0e+00

acetate kinase A/propionate kinase 2; Reviewed


:

Pssm-ID: 234680  Cd Length: 402  Bit Score: 718.05  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144   1 MNILVLNCGSSSVKYKLMEMPQANVLAQGVVEKLGLEDSFLRFKLPNGDKVVLEKYMPEHTVAIDFVLQTLTSEKYGCIK 80
Cdd:PRK00180    1 MKILVLNAGSSSLKFQLIDMPNEEVLASGLVERIGLPDSRIKIKVDGGEKEEEELPIPDHAEALKFLLNTLTDGKLGLIK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144  81 SLKEIDAVGHRLVHGGDKFSKSVIITDEVVAKVTECIDLAPLHNPPSLKGIAAVTELMPGVPQVGVFDTSFQQTMPEHAY 160
Cdd:PRK00180   81 DLDEITAVGHRVVHGGEKFTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNVPQVAVFDTAFHQTMPEEAY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144 161 MYALPYEYYEKYGVRRYGFHGTSHRYVSQRACEFLGLDFKKTRIITAHIGNGASISAIKNGECIDTSLGLTPTEGLIMGT 240
Cdd:PRK00180  161 LYALPYELYEKYGIRRYGFHGTSHRYVSQRAAELLGKPLEELNLITCHLGNGASIAAIKNGKSVDTSMGFTPLEGLVMGT 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144 241 RCGDVDPGALVFIGEKEKMSYADLSNMINKKSGVLGISGVSSDMREIEAAIAAGNERAKLALEMYDYRIKKYVGALAAAM 320
Cdd:PRK00180  241 RSGDIDPAIIPYLMEKLGMSVDEIDNLLNKKSGLLGLSGVSSDMRDIEAAAEEGDERAKLALDVFVYRLAKYIGSYAAAL 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144 321 -GGVDVIVFTGGVGENQTTTREYVCRDMEYMGIQLDNELN-AKVRGEECLLSTADSKVKVVVIPTDEEKMIALDTLELIK 398
Cdd:PRK00180  321 nGRLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNlAARFGKEGDISTPDSKVKVLVIPTNEELMIARDTLRLLG 400


                  .
gi 1154824144 399 K 399
Cdd:PRK00180  401 K 401
 
Name Accession Description Interval E-value
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 1-399 0e+00

acetate kinase A/propionate kinase 2; Reviewed


Pssm-ID: 234680  Cd Length: 402  Bit Score: 718.05  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144   1 MNILVLNCGSSSVKYKLMEMPQANVLAQGVVEKLGLEDSFLRFKLPNGDKVVLEKYMPEHTVAIDFVLQTLTSEKYGCIK 80
Cdd:PRK00180    1 MKILVLNAGSSSLKFQLIDMPNEEVLASGLVERIGLPDSRIKIKVDGGEKEEEELPIPDHAEALKFLLNTLTDGKLGLIK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144  81 SLKEIDAVGHRLVHGGDKFSKSVIITDEVVAKVTECIDLAPLHNPPSLKGIAAVTELMPGVPQVGVFDTSFQQTMPEHAY 160
Cdd:PRK00180   81 DLDEITAVGHRVVHGGEKFTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNVPQVAVFDTAFHQTMPEEAY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144 161 MYALPYEYYEKYGVRRYGFHGTSHRYVSQRACEFLGLDFKKTRIITAHIGNGASISAIKNGECIDTSLGLTPTEGLIMGT 240
Cdd:PRK00180  161 LYALPYELYEKYGIRRYGFHGTSHRYVSQRAAELLGKPLEELNLITCHLGNGASIAAIKNGKSVDTSMGFTPLEGLVMGT 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144 241 RCGDVDPGALVFIGEKEKMSYADLSNMINKKSGVLGISGVSSDMREIEAAIAAGNERAKLALEMYDYRIKKYVGALAAAM 320
Cdd:PRK00180  241 RSGDIDPAIIPYLMEKLGMSVDEIDNLLNKKSGLLGLSGVSSDMRDIEAAAEEGDERAKLALDVFVYRLAKYIGSYAAAL 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144 321 -GGVDVIVFTGGVGENQTTTREYVCRDMEYMGIQLDNELN-AKVRGEECLLSTADSKVKVVVIPTDEEKMIALDTLELIK 398
Cdd:PRK00180  321 nGRLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNlAARFGKEGDISTPDSKVKVLVIPTNEELMIARDTLRLLG 400


                  .
gi 1154824144 399 K 399
Cdd:PRK00180  401 K 401
AckA COG0282
Acetate kinase [Energy production and conversion];
1-398 0e+00

Acetate kinase [Energy production and conversion];


Pssm-ID: 440051  Cd Length: 395  Bit Score: 712.96  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144   1 MNILVLNCGSSSVKYKLMEMPQANVLAQGVVEKLGLEDSFLRFKLPNGDKVVLEKYMPEHTVAIDFVLQTLTSEKYgcIK 80
Cdd:COG0282     1 MKILVLNAGSSSLKFQLFDMDSEEVLAKGLVERIGLPGARLKHKDAGGEKVERELPIPDHAAALALVLELLTDHGI--IK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144  81 SLKEIDAVGHRLVHGGDKFSKSVIITDEVVAKVTECIDLAPLHNPPSLKGIAAVTELMPGVPQVGVFDTSFQQTMPEHAY 160
Cdd:COG0282    79 DLDEIDAVGHRVVHGGEKFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQTMPEVAY 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144 161 MYALPYEYYEKYGVRRYGFHGTSHRYVSQRACEFLGLDFKKTRIITAHIGNGASISAIKNGECIDTSLGLTPTEGLIMGT 240
Cdd:COG0282   159 LYALPYELYEKYGIRRYGFHGTSHRYVAERAAELLGKPLADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVMGT 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144 241 RCGDVDPGALVFIGEKEKMSYADLSNMINKKSGVLGISGVSSDMREIEAAIAAGNERAKLALEMYDYRIKKYVGALAAAM 320
Cdd:COG0282   239 RSGDIDPGVVLYLMRKEGLSADEVDDLLNKESGLLGLSGISSDMRDLEEAAASGDERARLALDMFVYRIKKYIGAYAAAL 318

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1154824144 321 GGVDVIVFTGGVGENQTTTREYVCRDMEYMGIQLDNELNAkVRGEECLLSTADSKVKVVVIPTDEEKMIALDTLELIK 398
Cdd:COG0282   319 GGLDALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANA-ARGGERVISTPDSRVKVLVIPTNEELMIARDTLRLLK 395
ASKHA_NBD_AcK_PK cd24010
nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain ...
 3-396 0e+00

nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain family; The family corresponds to a group of proteins which transfer phosphate from ATP to a short chain aliphatic acid. It includes acetate kinase (AckA) and propionate kinase (TdcD and PduW). Acetate kinase (EC 2.7.2.1), also called acetokinase, catalyzes the formation of acetyl phosphate from acetate and ATP. It can also catalyze the reverse reaction in the presence of a divalent cation. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically. Propionate kinase TdcD (EC 2.7.2.15) catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor. The family also includes propionate kinase PduW (EC 2.7.2.15) that works with phosphate acetyltransferase (pta) to capture exogenous propionate and regenerate propionyl-CoA during degradation of propionate and 1,2-propanediol (1,2-PD). This protein restores growth to an eutQ deletion on ethanolamine and tetrathionate under anoxic conditions. The AcK/PK family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466860  Cd Length: 392  Bit Score: 676.53  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144   3 ILVLNCGSSSVKYKLMEMPQANVLAQGVVEKLGLEDSFLRFKLPNGDKVVLEKYMPEHTVAIDFVLQTLTSEKYGCikSL 82
Cdd:cd24010     1 ILVINCGSSSLKFQLFDMPTEEVLASGLVERIGLEGARLKHKVNNGEKIKEELPIPDHEEALKAILDTLTDPELGV--SL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144  83 KEIDAVGHRLVHGGDKFSKSVIITDEVVAKVTECIDLAPLHNPPSLKGIAAVTELMPGVPQVGVFDTSFQQTMPEHAYMY 162
Cdd:cd24010    79 DEIDAVGHRVVHGGEKFTESVLIDDEVIAAIEDLSPLAPLHNPANLAGIEAARKLLPDVPQVAVFDTAFHQTMPPHAYLY 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144 163 ALPYEYYEKYGVRRYGFHGTSHRYVSQRACEFLGLDFKKTRIITAHIGNGASISAIKNGECIDTSLGLTPTEGLIMGTRC 242
Cdd:cd24010   159 ALPYELYEKYGIRRYGFHGTSHRYVSRRAAELLGKPLEDLNLITCHLGNGASICAIKNGKSVDTSMGLTPLEGLVMGTRS 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144 243 GDVDPGALVFIGEKEKMSYADLSNMINKKSGVLGISGVSSDMREIEAAIAAGNERAKLALEMYDYRIKKYVGALAAAMGG 322
Cdd:cd24010   239 GDIDPAIVFYLMKKEGMSVDEIERLLNKKSGLLGISGVSSDMRDIEEAAEEGDERAKLALDVFVYRIKKYIGAYAAALGG 318

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1154824144 323 VDVIVFTGGVGENQTTTREYVCRDMEYMGIQLDNELNAKVRGEECLLSTADSKVKVVVIPTDEEKMIALDTLEL 396
Cdd:cd24010   319 VDAIVFTGGIGENSALIRELVCEGLEFLGIELDEEKNKAAGGGEREISTPDSKVKVLVIPTNEELMIARDTVRL 392
Acetate_kinase pfam00871
Acetokinase family; This family includes acetate kinase, butyrate kinase and ...
 3-391 0e+00

Acetokinase family; This family includes acetate kinase, butyrate kinase and 2-methylpropanoate kinase.


Pssm-ID: 395700  Cd Length: 387  Bit Score: 537.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144   3 ILVLNCGSSSVKYKLMEMPQANVLAQGVVEKLGLEDSFLRFKLPNGDKVVLEKYMPEHTVAIDFVLQTLtsEKYGCIKSL 82
Cdd:pfam00871   2 VLVLNAGSSSIKFQLFDAVIGEVLLSGLAERIGLPNARILWKMNGGKKNAALLAGADHSEALNFILNTL--LKHKIIELL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144  83 KEIDAVGHRLVHGGDKFSKSVIITDEVVAKVTECIDLAPLHNPPSLKGIAAVTELMPGVPQVGVFDTSFQQTMPEHAYMY 162
Cdd:pfam00871  80 AEITLIGHRVVHGGEKFTESVLITDEVIQGIKDLIPLAPLHNPAHLDGIEEAFKLFPQVKNVAVFDTAFHQTMPEEAYLY 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144 163 ALPYEYYEKYGVRRYGFHGTSHRYVSQRACEFLGLDFKKTRIITAHIGNGASISAIKNGECIDTSLGLTPTEGLIMGTRC 242
Cdd:pfam00871 160 ALPYSWYKEHGIRRYGFHGTSHKYVSQRAAKILNKPLEDLNLITCHLGNGASVCAVRNGKSVDTSMGFTPLEGLVMGTRS 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144 243 GDVDPGALVFIGEKEKMSYADLSNMINKKSGVLGISGVSSDMREIEAAIAAGNERAKLALEMYDYRIKKYVGALAAAMGG 322
Cdd:pfam00871 240 GDIDPAIIFYLAETLGMSADEINNTLNKKSGLLGLSGVSSDLRYVEDAYAEGKEDAQLAIKVYVHRLAKYIGSYAASLER 319

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1154824144 323 VDVIVFTGGVGENQTTTREYVCRDMEYMGIQLDNELNAKvRGEECLLSTADSKVKVVVIPTDEEKMIAL 391
Cdd:pfam00871 320 LDAIVFTGGIGENAAMVRELVLNALEVLGFEIDPERNNR-FGKSGVISTEDSRVKVVVIPTNEELMIAQ 387
ackA TIGR00016
acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in ...
 1-398 0e+00

acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in the secretion of acetate. It catalyzes the reaction ATP + acetate = ADP + acetyl phosphate. Some members of this family have been shown to act on propionate as well as acetate. An example of a propionate/acetate kinase is TdcD of E. coli (SP|P11868), an enzyme of an anaerobic pathway of threonine catabolism. It is not known how many members of this family act on additional substrates besides acetate. [Energy metabolism, Fermentation]


Pssm-ID: 272856  Cd Length: 404  Bit Score: 528.52  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144   1 MNILVLNCGSSSVKYKLMEMPQAN-VLAQGVVEKLGLEDSFLRFKLPNGDKVVLEKYMPEHTVAIDFVLQTLTseKYGCI 79
Cdd:TIGR00016   4 MKILVLNAGSSSLKFALFDAVNGEeVLASGLAERIFLPNARIKWVEDGGKKEAELLAGADHQEALKFILNTLL--KDKII 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144  80 KSLKEIDAVGHRLVHGGDKFSKSVIITDEVVAKVTECIDLAPLHNPPSLKGIAAVTELMPG--VPQVGVFDTSFQQTMPE 157
Cdd:TIGR00016  82 KLLSEIDLIGHRVVHGGEKFTDSVIITDEVIQKIKDISPLAPLHNPAHLIGIEAALKLFPLpkAKNVAVFDTAFHQTMPE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144 158 HAYMYALPYEYYEKYGVRRYGFHGTSHRYVSQRACEFLGLDFKKTRIITAHIGNGASISAIKNGECIDTSLGLTPTEGLI 237
Cdd:TIGR00016 162 EAYLYALPYSWYKEHGVRRYGFHGTSHKYVTQRAAKILNKPLDDLNLIVCHLGNGASVCAIKNGKSIDTSMGFTPLEGLM 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144 238 MGTRCGDVDPGALVFIGEKEKMSYADLSNMINKKSGVLGISGVSSDMREIEAAIAAGNERAKLALEMYDYRIKKYVGALA 317
Cdd:TIGR00016 242 MGTRSGDIDPAIIFYLAETLGMSADDIENTLNKKSGLLGISGLSSDLRDIEDAYAEGNEQAKLAIKVYVHRIAKYIGSYI 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144 318 AAMGG-VDVIVFTGGVGENQTTTREYVCRDMEYMGIQLDNELN-AKVRGEECLLSTADSKVKVVVIPTDEEKMIALDTLE 395
Cdd:TIGR00016 322 ASLEGnLDAIVFTGGIGENAAMVRELVLEKLEVLGFELDPELNnAARSGKSGVISTPESKVKILVIPTNEELMIAQDAIR 401


                  ...
gi 1154824144 396 LIK 398
Cdd:TIGR00016 402 LTK 404
 
Name Accession Description Interval E-value
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 1-399 0e+00

acetate kinase A/propionate kinase 2; Reviewed


Pssm-ID: 234680  Cd Length: 402  Bit Score: 718.05  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144   1 MNILVLNCGSSSVKYKLMEMPQANVLAQGVVEKLGLEDSFLRFKLPNGDKVVLEKYMPEHTVAIDFVLQTLTSEKYGCIK 80
Cdd:PRK00180    1 MKILVLNAGSSSLKFQLIDMPNEEVLASGLVERIGLPDSRIKIKVDGGEKEEEELPIPDHAEALKFLLNTLTDGKLGLIK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144  81 SLKEIDAVGHRLVHGGDKFSKSVIITDEVVAKVTECIDLAPLHNPPSLKGIAAVTELMPGVPQVGVFDTSFQQTMPEHAY 160
Cdd:PRK00180   81 DLDEITAVGHRVVHGGEKFTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNVPQVAVFDTAFHQTMPEEAY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144 161 MYALPYEYYEKYGVRRYGFHGTSHRYVSQRACEFLGLDFKKTRIITAHIGNGASISAIKNGECIDTSLGLTPTEGLIMGT 240
Cdd:PRK00180  161 LYALPYELYEKYGIRRYGFHGTSHRYVSQRAAELLGKPLEELNLITCHLGNGASIAAIKNGKSVDTSMGFTPLEGLVMGT 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144 241 RCGDVDPGALVFIGEKEKMSYADLSNMINKKSGVLGISGVSSDMREIEAAIAAGNERAKLALEMYDYRIKKYVGALAAAM 320
Cdd:PRK00180  241 RSGDIDPAIIPYLMEKLGMSVDEIDNLLNKKSGLLGLSGVSSDMRDIEAAAEEGDERAKLALDVFVYRLAKYIGSYAAAL 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144 321 -GGVDVIVFTGGVGENQTTTREYVCRDMEYMGIQLDNELN-AKVRGEECLLSTADSKVKVVVIPTDEEKMIALDTLELIK 398
Cdd:PRK00180  321 nGRLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNlAARFGKEGDISTPDSKVKVLVIPTNEELMIARDTLRLLG 400


                  .
gi 1154824144 399 K 399
Cdd:PRK00180  401 K 401
AckA COG0282
Acetate kinase [Energy production and conversion];
1-398 0e+00

Acetate kinase [Energy production and conversion];


Pssm-ID: 440051  Cd Length: 395  Bit Score: 712.96  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144   1 MNILVLNCGSSSVKYKLMEMPQANVLAQGVVEKLGLEDSFLRFKLPNGDKVVLEKYMPEHTVAIDFVLQTLTSEKYgcIK 80
Cdd:COG0282     1 MKILVLNAGSSSLKFQLFDMDSEEVLAKGLVERIGLPGARLKHKDAGGEKVERELPIPDHAAALALVLELLTDHGI--IK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144  81 SLKEIDAVGHRLVHGGDKFSKSVIITDEVVAKVTECIDLAPLHNPPSLKGIAAVTELMPGVPQVGVFDTSFQQTMPEHAY 160
Cdd:COG0282    79 DLDEIDAVGHRVVHGGEKFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQTMPEVAY 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144 161 MYALPYEYYEKYGVRRYGFHGTSHRYVSQRACEFLGLDFKKTRIITAHIGNGASISAIKNGECIDTSLGLTPTEGLIMGT 240
Cdd:COG0282   159 LYALPYELYEKYGIRRYGFHGTSHRYVAERAAELLGKPLADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVMGT 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144 241 RCGDVDPGALVFIGEKEKMSYADLSNMINKKSGVLGISGVSSDMREIEAAIAAGNERAKLALEMYDYRIKKYVGALAAAM 320
Cdd:COG0282   239 RSGDIDPGVVLYLMRKEGLSADEVDDLLNKESGLLGLSGISSDMRDLEEAAASGDERARLALDMFVYRIKKYIGAYAAAL 318

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1154824144 321 GGVDVIVFTGGVGENQTTTREYVCRDMEYMGIQLDNELNAkVRGEECLLSTADSKVKVVVIPTDEEKMIALDTLELIK 398
Cdd:COG0282   319 GGLDALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANA-ARGGERVISTPDSRVKVLVIPTNEELMIARDTLRLLK 395
ASKHA_NBD_AcK_PK cd24010
nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain ...
 3-396 0e+00

nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain family; The family corresponds to a group of proteins which transfer phosphate from ATP to a short chain aliphatic acid. It includes acetate kinase (AckA) and propionate kinase (TdcD and PduW). Acetate kinase (EC 2.7.2.1), also called acetokinase, catalyzes the formation of acetyl phosphate from acetate and ATP. It can also catalyze the reverse reaction in the presence of a divalent cation. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically. Propionate kinase TdcD (EC 2.7.2.15) catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor. The family also includes propionate kinase PduW (EC 2.7.2.15) that works with phosphate acetyltransferase (pta) to capture exogenous propionate and regenerate propionyl-CoA during degradation of propionate and 1,2-propanediol (1,2-PD). This protein restores growth to an eutQ deletion on ethanolamine and tetrathionate under anoxic conditions. The AcK/PK family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466860  Cd Length: 392  Bit Score: 676.53  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144   3 ILVLNCGSSSVKYKLMEMPQANVLAQGVVEKLGLEDSFLRFKLPNGDKVVLEKYMPEHTVAIDFVLQTLTSEKYGCikSL 82
Cdd:cd24010     1 ILVINCGSSSLKFQLFDMPTEEVLASGLVERIGLEGARLKHKVNNGEKIKEELPIPDHEEALKAILDTLTDPELGV--SL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144  83 KEIDAVGHRLVHGGDKFSKSVIITDEVVAKVTECIDLAPLHNPPSLKGIAAVTELMPGVPQVGVFDTSFQQTMPEHAYMY 162
Cdd:cd24010    79 DEIDAVGHRVVHGGEKFTESVLIDDEVIAAIEDLSPLAPLHNPANLAGIEAARKLLPDVPQVAVFDTAFHQTMPPHAYLY 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144 163 ALPYEYYEKYGVRRYGFHGTSHRYVSQRACEFLGLDFKKTRIITAHIGNGASISAIKNGECIDTSLGLTPTEGLIMGTRC 242
Cdd:cd24010   159 ALPYELYEKYGIRRYGFHGTSHRYVSRRAAELLGKPLEDLNLITCHLGNGASICAIKNGKSVDTSMGLTPLEGLVMGTRS 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144 243 GDVDPGALVFIGEKEKMSYADLSNMINKKSGVLGISGVSSDMREIEAAIAAGNERAKLALEMYDYRIKKYVGALAAAMGG 322
Cdd:cd24010   239 GDIDPAIVFYLMKKEGMSVDEIERLLNKKSGLLGISGVSSDMRDIEEAAEEGDERAKLALDVFVYRIKKYIGAYAAALGG 318

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1154824144 323 VDVIVFTGGVGENQTTTREYVCRDMEYMGIQLDNELNAKVRGEECLLSTADSKVKVVVIPTDEEKMIALDTLEL 396
Cdd:cd24010   319 VDAIVFTGGIGENSALIRELVCEGLEFLGIELDEEKNKAAGGGEREISTPDSKVKVLVIPTNEELMIARDTVRL 392
Acetate_kinase pfam00871
Acetokinase family; This family includes acetate kinase, butyrate kinase and ...
 3-391 0e+00

Acetokinase family; This family includes acetate kinase, butyrate kinase and 2-methylpropanoate kinase.


Pssm-ID: 395700  Cd Length: 387  Bit Score: 537.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144   3 ILVLNCGSSSVKYKLMEMPQANVLAQGVVEKLGLEDSFLRFKLPNGDKVVLEKYMPEHTVAIDFVLQTLtsEKYGCIKSL 82
Cdd:pfam00871   2 VLVLNAGSSSIKFQLFDAVIGEVLLSGLAERIGLPNARILWKMNGGKKNAALLAGADHSEALNFILNTL--LKHKIIELL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144  83 KEIDAVGHRLVHGGDKFSKSVIITDEVVAKVTECIDLAPLHNPPSLKGIAAVTELMPGVPQVGVFDTSFQQTMPEHAYMY 162
Cdd:pfam00871  80 AEITLIGHRVVHGGEKFTESVLITDEVIQGIKDLIPLAPLHNPAHLDGIEEAFKLFPQVKNVAVFDTAFHQTMPEEAYLY 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144 163 ALPYEYYEKYGVRRYGFHGTSHRYVSQRACEFLGLDFKKTRIITAHIGNGASISAIKNGECIDTSLGLTPTEGLIMGTRC 242
Cdd:pfam00871 160 ALPYSWYKEHGIRRYGFHGTSHKYVSQRAAKILNKPLEDLNLITCHLGNGASVCAVRNGKSVDTSMGFTPLEGLVMGTRS 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144 243 GDVDPGALVFIGEKEKMSYADLSNMINKKSGVLGISGVSSDMREIEAAIAAGNERAKLALEMYDYRIKKYVGALAAAMGG 322
Cdd:pfam00871 240 GDIDPAIIFYLAETLGMSADEINNTLNKKSGLLGLSGVSSDLRYVEDAYAEGKEDAQLAIKVYVHRLAKYIGSYAASLER 319

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1154824144 323 VDVIVFTGGVGENQTTTREYVCRDMEYMGIQLDNELNAKvRGEECLLSTADSKVKVVVIPTDEEKMIAL 391
Cdd:pfam00871 320 LDAIVFTGGIGENAAMVRELVLNALEVLGFEIDPERNNR-FGKSGVISTEDSRVKVVVIPTNEELMIAQ 387
ackA TIGR00016
acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in ...
 1-398 0e+00

acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in the secretion of acetate. It catalyzes the reaction ATP + acetate = ADP + acetyl phosphate. Some members of this family have been shown to act on propionate as well as acetate. An example of a propionate/acetate kinase is TdcD of E. coli (SP|P11868), an enzyme of an anaerobic pathway of threonine catabolism. It is not known how many members of this family act on additional substrates besides acetate. [Energy metabolism, Fermentation]


Pssm-ID: 272856  Cd Length: 404  Bit Score: 528.52  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144   1 MNILVLNCGSSSVKYKLMEMPQAN-VLAQGVVEKLGLEDSFLRFKLPNGDKVVLEKYMPEHTVAIDFVLQTLTseKYGCI 79
Cdd:TIGR00016   4 MKILVLNAGSSSLKFALFDAVNGEeVLASGLAERIFLPNARIKWVEDGGKKEAELLAGADHQEALKFILNTLL--KDKII 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144  80 KSLKEIDAVGHRLVHGGDKFSKSVIITDEVVAKVTECIDLAPLHNPPSLKGIAAVTELMPG--VPQVGVFDTSFQQTMPE 157
Cdd:TIGR00016  82 KLLSEIDLIGHRVVHGGEKFTDSVIITDEVIQKIKDISPLAPLHNPAHLIGIEAALKLFPLpkAKNVAVFDTAFHQTMPE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144 158 HAYMYALPYEYYEKYGVRRYGFHGTSHRYVSQRACEFLGLDFKKTRIITAHIGNGASISAIKNGECIDTSLGLTPTEGLI 237
Cdd:TIGR00016 162 EAYLYALPYSWYKEHGVRRYGFHGTSHKYVTQRAAKILNKPLDDLNLIVCHLGNGASVCAIKNGKSIDTSMGFTPLEGLM 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144 238 MGTRCGDVDPGALVFIGEKEKMSYADLSNMINKKSGVLGISGVSSDMREIEAAIAAGNERAKLALEMYDYRIKKYVGALA 317
Cdd:TIGR00016 242 MGTRSGDIDPAIIFYLAETLGMSADDIENTLNKKSGLLGISGLSSDLRDIEDAYAEGNEQAKLAIKVYVHRIAKYIGSYI 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144 318 AAMGG-VDVIVFTGGVGENQTTTREYVCRDMEYMGIQLDNELN-AKVRGEECLLSTADSKVKVVVIPTDEEKMIALDTLE 395
Cdd:TIGR00016 322 ASLEGnLDAIVFTGGIGENAAMVRELVLEKLEVLGFELDPELNnAARSGKSGVISTPESKVKILVIPTNEELMIAQDAIR 401


                  ...
gi 1154824144 396 LIK 398
Cdd:TIGR00016 402 LTK 404
PRK12379 PRK12379
propionate kinase;
3-396 7.91e-160

propionate kinase;


Pssm-ID: 183484  Cd Length: 396  Bit Score: 454.96  E-value: 7.91e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144   3 ILVLNCGSSSVKYKLMEMPQANVLAQGVVEKLGLEDSFLRFKlpNGDKVVLEKYMPEHTV-AIDFVLqtltsEKYGCIKS 81
Cdd:PRK12379    7 VLVINCGSSSIKFSVLDASDCEVLMSGIADGINSENAFLSVN--GGEPAPLAHHSYEGALkAIAFEL-----EKRNLNDS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144  82 lkeIDAVGHRLVHGGDKFSKSVIITDEVVAKVTECIDLAPLHNPPSLKGIAAVTELMPGVPQVGVFDTSFQQTMPEHAYM 161
Cdd:PRK12379   80 ---VALIGHRIAHGGSIFTESVIITDEVIDNIRRVSPLAPLHNYANLSGIEAAQQLFPGVTQVAVFDTSFHQTLAPEAYL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144 162 YALPYEYYEKYGVRRYGFHGTSHRYVSQRACEFLGLDFKKTRIITAHIGNGASISAIKNGECIDTSLGLTPTEGLIMGTR 241
Cdd:PRK12379  157 YGLPWEYYEELGVRRYGFHGTSHRYVSQRAHSLLNLDEDDSGLVVAHLGNGASICAVRNGQSVDTSMGMTPLEGLMMGTR 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144 242 CGDVDPGALVFIGEKEKMSYADLSNMINKKSGVLGISGVSSDMREIEAAIAAGNERAKLALEMYDYRIKKYVGALAAAMG 321
Cdd:PRK12379  237 SGDVDFGAMAWIASQTGQTLGDLERVVNKESGLLGISGLSSDLRVLEKAWHEGHERAQLAIKTFVHRIARHIAGHAASLH 316

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1154824144 322 GVDVIVFTGGVGENQTTTREYVCRDMEYMGIQLDNELNAKV-RGEECLLSTADSKVKVVVIPTDEEKMIALDTLEL 396
Cdd:PRK12379  317 RLDGIIFTGGIGENSSLIRRLVMEHLAVLGLEIDTEMNNQPnSGGERIISSENSRVICAVIPTNEEKMIALDAIHL 392
PRK12397 PRK12397
acetate/propionate family kinase;
3-396 4.97e-149

acetate/propionate family kinase;


Pssm-ID: 183500  Cd Length: 404  Bit Score: 428.10  E-value: 4.97e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144   3 ILVLNCGSSSVKYKLMEMPQANVLAQGVVEKLGLEDSflRFKLPNGDKVVLEKY-MPEHTVAIDFVLQTLTSekYGCIKS 81
Cdd:PRK12397    5 IMAINAGSSSLKFQLLEMPQGDMLCQGLIERIGMADA--QVTIKTHSQKWQETVpVADHRDAVTLLLEKLLG--YQIINS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144  82 LKEIDAVGHRLVHGGDKFSKSVIITDEVVAKVTECIDLAPLHNPPSLKGIAAVTELMPGVPQVGVFDTSFQQTMPEHAYM 161
Cdd:PRK12397   81 LRDIDGVGHRVAHGGEFFKDSTLVTDETLAQIERLAELAPLHNPVNALGIHVFRQLLPDAPSVAVFDTAFHQTLDEPAYI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144 162 YALPYEYYEKYGVRRYGFHGTSHRYVSQRACEFLGLDFKKTRIITAHIGNGASISAIKNGECIDTSLGLTPTEGLIMGTR 241
Cdd:PRK12397  161 YPLPWRYYAELGIRRYGFHGTSHKYVSGVLAEKLGVPLSALRVICCHLGNGSSICAIKNGRSVNTSMGFTPQSGVMMGTR 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144 242 CGDVDPGALVFIGEKEKMSYADLSNMINKKSGVLGISGVSSDMREIEAAIAAGNERAKLALEMYDYRIKKYVGALAAAMG 321
Cdd:PRK12397  241 SGDIDPSILPWIAQREGKTPQQLNQLLNNESGLLGVSGVSSDYRDVEQAANTGNRQAKLALTLFAERIRATIGSYIMQMG 320

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1154824144 322 GVDVIVFTGGVGENQTTTREYVCRDMEYMGIQLDNELNAKvrgEECLLSTADSKVKVVVIPTDEEKMIALDTLEL 396
Cdd:PRK12397  321 GLDALVFTGGIGENSARARSAVCHNLQFLGLAVDEEKNQR---NATFIQTENALVKVAVINTNEELMIAQDVMRI 392
PRK07157 PRK07157
acetate kinase; Provisional
 1-399 1.20e-131

acetate kinase; Provisional


Pssm-ID: 235948  Cd Length: 400  Bit Score: 383.71  E-value: 1.20e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144   1 MNILVLNCGSSSVKYKLMEMPQANVLAQGVVEKLGLEDSFLRFKLPNgDKVVLEKYMPEHTVAIDFVLQTLTSEKYgcIK 80
Cdd:PRK07157    3 AKILVINAGSSSIKWQLFDKENLNLIASGLAERIGLENGLIKIKFGK-KKYEKEVDMPNHKVAVAVLIEIWEENKL--IE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144  81 SLKEIDAVGHRLVHGGDKFSKSVIITDEVVAKVTECIDLAPLHNPPSLKGIAAVTELMPGVPQVGVFDTSFQQTMPEHAY 160
Cdd:PRK07157   80 DLEEIELIGFRVVHGGDYFNGPTKLDDKEISKIEKVAKYAPLHNPGALQTIKAFKKVLPKAKLSASFDTAFHTSIPKINY 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144 161 MYALPYEYYEKYGVRRYGFHGTSHRYVSQRACEFLglDFKKTRIITAHIGNGASISAIKNGECIDTSLGLTPTEGLIMGT 240
Cdd:PRK07157  160 TYPINYEIAKKYGIKKYGFHGISHKFITNKVEKIL--NKDKVNFVNLHIGNGASLCAIKNSKSIDTSMGLTPLAGVMMGT 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144 241 RCGDVDPGALVFIGEKEKMSYADLSNMINKKSGVLGISGVSSDMREIEAAIAAGNERAKLALEMYDYRIKKYVGALAAAM 320
Cdd:PRK07157  238 RSGDIDPSIHEFVAKEANMSISEFTDLLNKKSGLLGVSGISSDLRDVIKAAESGNKRAKFALDLYAQKIVDYLANYINKI 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144 321 GG-VDVIVFTGGVGENQTTTREYVCRDMEYMGIQLDNELNAKVRGEEC---LLSTADSKVKVVVIPTDEEKMIALDTLEL 396
Cdd:PRK07157  318 GKkIDAIVFTAGVGENSAFVRELVINKINIPNIKLDKEKNLKKIGEYGpieLISTPDSDIPVYVIRTNEELLIAKNAIKL 397


                  ...
gi 1154824144 397 IKK 399
Cdd:PRK07157  398 YEN 400
PRK12440 PRK12440
acetate/propionate family kinase;
3-397 1.34e-118

acetate/propionate family kinase;


Pssm-ID: 183528  Cd Length: 397  Bit Score: 350.32  E-value: 1.34e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144   3 ILVLNCGSSSVKYKLMEMPQANVLAQGVVEKLGLEDSFLRFKLpNGDK--VVLEKYMPEHTVAIDFVLQTLTSEKYGcik 80
Cdd:PRK12440    6 VLVINSGSSSLKFAVIDSVTGEAVLSGLGECFGLEDARMSWKY-QGEKteIAIEGEDNHHKIAIGRLVGLTEELGFT--- 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144  81 slKEIDAVGHRLVHGGDKFSKSVIITDEVVAKVTECIDLAPLHNPPSLKGIAAVTELMPGVPQVGVFDTSFQQTMPEHAY 160
Cdd:PRK12440   82 --QDIVAVGHRIVHGGEKFTSTVRIDEEVTAEIESLSDLAPLHNPAGAIGIRAAMAAFPSLPQFAVFDTAFHQTMPKKAF 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144 161 MYALPYEYYEKYGVRRYGFHGTSHRYVSQRACEFLGLDFKKTRIITAHIGNGASISAIKNGECIDTSLGLTPTEGLIMGT 240
Cdd:PRK12440  160 TGAIAKELYTDFGIRRYGFHGTSHYFVSREAAKMLNKPIEESSFISVHLGNGASVCAIKNGQSVDTSMGFTPLSGLMMGT 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144 241 RCGDVDPGALVFIgEKEKMSYADLSNMINKKSGVLGISGVSSDMREIEAAIAAGNERAKLALEMYDYRIKKYVGALAAAM 320
Cdd:PRK12440  240 RCGDLDPGIIEFL-LKKGWSQEKVFNSLNKKSGFLGVSGLTSDARGILEAMEEGHEGATLAFEVFTYRVAKYIASYLAAL 318

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1154824144 321 GGVDVIVFTGGVGENQTTTREYVCRDMEYMGIQLDNELNAKVR-GEECLLSTADS-KVKVVVIPTDEEKMIALDTLELI 397
Cdd:PRK12440  319 DSLDGIIFTGGIGENSLPIRREILKNLKLLGFVEDEKGNEDARfGKAGIIAKSELlNAVAMVIPTNEEFVIAQQSVELL 397
PRK07058 PRK07058
acetate/propionate family kinase;
3-397 1.52e-104

acetate/propionate family kinase;


Pssm-ID: 235922  Cd Length: 396  Bit Score: 314.29  E-value: 1.52e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144   3 ILVLNCGSSSVKYKLMEM--PQANVLAQGVVEklgLEDSFLRFKLPNGDKVVLEKYMPEHTVAIDFVL-QTLtsEKYGCI 79
Cdd:PRK07058    6 LLTFNAGSSTVKIGLFEVdgNEARRIGKGDID---FRRAPLRFHLRNGGETLDIPLKASVTDDLHTVLdETF--DWLAAH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144  80 KSLKEIDAVGHRLVHGGDKFSKSVIITDEVVAKVTECIDLAPLHNPPSLKGIAAVTELMPGVPQVGVFDTSFQQTMPEHA 159
Cdd:PRK07058   81 FDVSELVAVGHRVVHGGDRFAGAVLIDDATLDAIEALVPLAPLHQPQSLRLIRAIRHLRPHLPQTASFDTAFHRTQPDLV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144 160 YMYALPYEYYEKyGVRRYGFHGTSHRYVSQRACEfLGLDFKKTRIITAHIGNGASISAIKNGECIDTSLGLTPTEGLIMG 239
Cdd:PRK07058  161 RRFAIPRALHDE-GIKRYGFHGLSYKFVAGELRR-RAPELARGKVVAAHLGSGASLCALDAGKSRDTSMGFSTLDGIPMA 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144 240 TRCGDVDPGALVFIGEKEKMSYADLSNMINKKSGVLGISGVSSDMREIEAAIAAGnerAKLALEMYDYRIKKYVGALAAA 319
Cdd:PRK07058  239 TRCGALDPGVVLHLLKQEGMSLDEVEDLLYHRSGLLGVSGISGDTRDLLASDAPE---AREALDLFALRIAGEIARLAAT 315

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1154824144 320 MGGVDVIVFTGGVGENQTTTREYVCRDMEYMGIQLDNELNAKvrgEECLLSTADSKVKVVVIPTDEEKMIALDTLELI 397
Cdd:PRK07058  316 LGGLDAVVFTAGIGEHQPAIRAAVCERLAWLGVELDPAANAA---NAFTISSRTSRVAAFVIPTDEEQVIADEAFSVL 390
ASKHA_NBD_BK cd24011
nucleotide-binding domain (NBD) of the butyrate kinase (BK) domain family; Butyrate kinase (EC ...
 175-332 1.26e-34

nucleotide-binding domain (NBD) of the butyrate kinase (BK) domain family; Butyrate kinase (EC 2.7.2.7) catalyzes the formation of butyryl-CoA by phosphorylating butyrate in the presence of ATP to form butyryl phosphate. Butyrate kinases exist in many fermentative species of the bacterial and archaeal families. They belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466861  Cd Length: 345  Bit Score: 130.73  E-value: 1.26e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144 175 RRYGFHGTSHRYVSQRACEFLGLDFKKTRIITAHIGNGASISAIKNGECIDTSLGLtPTEGLIMGTRCGDVDPGALVFIG 254
Cdd:cd24011   147 RRSIFHALNQKAVARRAAKELGKPYEELNLIVAHLGGGISVGAHRKGRVIDVNNAL-DGEGPFSPERAGTLPVGDLIKLC 225

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1154824144 255 EKEKMSYADLSNMINKKSGVLGISGVsSDMREIEAAIAAGNERAKLALEMYDYRIKKYVGALAAAMGG-VDVIVFTGGV 332
Cdd:cd24011   226 FSGKYTLEELKKKLKGKGGLVAYLGT-NDFREVEKRIEAGDEKAKLVLDAMAYQIAKEIGALAAVLKGkVDAIILTGGL 303
PRK03011 PRK03011
butyrate kinase; Provisional
 175-332 2.54e-28

butyrate kinase; Provisional


Pssm-ID: 235099  Cd Length: 358  Bit Score: 113.72  E-value: 2.54e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154824144 175 RRYGFHGTSHRYVSQRACEFLGLDFKKTRIITAHIGNGASISAIKNGECIDTSLGLtPTEGLIMGTRCGDVDPGALVFIG 254
Cdd:PRK03011  149 RKSIFHALNQKAVARRVAKELGKKYEELNLIVAHLGGGISVGAHRKGRVIDVNNAL-DGEGPFSPERAGGLPVGDLVELC 227

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1154824144 255 EKEKMSYADLSNMINKKSGVLGISGvSSDMREIEAAIAAGNERAKLALEMYDYRIKKYVGALAAAMGG-VDVIVFTGGV 332
Cdd:PRK03011  228 FSGKYTKEELKKKLVGKGGLVAYLG-TNDAREVEKRIEEGDEKAKLVYEAMAYQIAKEIGAMAAVLKGkVDAIVLTGGL 305
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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