NCBI Conserved Domain Search

Conserved domains on [gi|1148848711|ref|WP_077571107|]

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PAS domain S-box protein [Paenibacillus ihbetae]

Protein Classification

sensor histidine kinase( domain architecture ID 1001154)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals

EC: 2.7.13.3

Gene Ontology: GO:0004673|GO:0000155

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

KinA super family

cl47424

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...

404-755

4.26e-128

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

The actual alignment was detected with superfamily member COG5805:

Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 391.02 E-value: 4.26e-128

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 404 SQLKQMVEENQSVKEYLESIINQTADAIHTTDTHERVISVNNAFEQLYGWKANEVIGQKL-ELVPPSKLDEERDRLRRLR 482
Cdd:COG5805   143 TKKKKIEEILQEQEERLQTLIENSPDLICVIDTDGRILFINESIERLFGAPREELIGKNLlELLHPCDKEEFKERIESIT 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 483 EGERLPPVETVRMRKDGSLIEVSISTSLVRDEQGQVTSMISVSRDVTERNRIEELLRRSEKLNTVGQLAAGVAHEIRNPL 562
Cdd:COG5805   223 EVWQEFIIEREIITKDGRIRYFEAVIVPLIDTDGSVKGILVILRDITEKKEAEELMARSEKLSIAGQLAAGIAHEIRNPL 302

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 563 TTLRGFLQLQQQTQSVNADHIDLMLSELDRINLIVSEFLILAKPQAIHFQERDVRGILRDVISFLDSQAHLYGVEVKLDF 642
Cdd:COG5805   303 TSIKGFLQLLQPGIEDKEEYFDIMLSELDRIESIISEFLALAKPQAVNKEKENINELIQDVVTLLETEAILHNIQIRLEL 382

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 643 SPEPALVHCEENQLKQVFINLLKNAFEAMPDGGTVTITLKrPGGDHVLITIQDEGHGIPEELMPHLGEPFITNKETGTGL 722
Cdd:COG5805   383 LDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTE-EEDNSVIIRVIDEGIGIPEERLKKLGEPFFTTKEKGTGL 461

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1148848711 723 GLMVSQRIIQGHQGTLEIESKSGVGTKISIVLP 755
Cdd:COG5805   462 GLMVSYKIIENHNGTIDIDSKVGKGTTFTITLP 494

HAMP

cd06225

Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ...

355-399

7.92e-13

Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.

Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 63.23 E-value: 7.92e-13

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1148848711 355 TKPIQSILRTVNDVADGHFDRRLEVTSRDELGQLAGRINAMTRNL 399
Cdd:cd06225     1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45

Tar super family

cl43297

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];

265-450

1.19e-12

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];

The actual alignment was detected with superfamily member COG0840:

Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 71.20 E-value: 1.19e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 265 GKLDQDMEAVRDAVSTGENVVLVDTIQGKKVLKSFIPIDYEDKPTNVIGVVMDYEAISSVMREQMISLVAISLVLLEIVI 344
Cdd:COG0840   117 ELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALLEAAALALAAAALALALLAAALLALVALAI 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 345 FGSYIVAGYFTKPIQSILRTVNDVADGHFDRRLEVTSRDELGQLAGRINAMTRNLGHYTSQLKQMVEENQSVKEYLESII 424
Cdd:COG0840   197 ILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENLRELVGQVRESAEQVASASEELAASA 276

                         170       180
                  ....*....|....*....|....*.
gi 1148848711 425 NQTADAihTTDTHERVISVNNAFEQL 450
Cdd:COG0840   277 EELAAG--AEEQAASLEETAAAMEEL 300

Name

Accession

Description

Interval

E-value

KinA

COG5805

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...

404-755

4.26e-128

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 391.02 E-value: 4.26e-128

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 404 SQLKQMVEENQSVKEYLESIINQTADAIHTTDTHERVISVNNAFEQLYGWKANEVIGQKL-ELVPPSKLDEERDRLRRLR 482
Cdd:COG5805   143 TKKKKIEEILQEQEERLQTLIENSPDLICVIDTDGRILFINESIERLFGAPREELIGKNLlELLHPCDKEEFKERIESIT 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 483 EGERLPPVETVRMRKDGSLIEVSISTSLVRDEQGQVTSMISVSRDVTERNRIEELLRRSEKLNTVGQLAAGVAHEIRNPL 562
Cdd:COG5805   223 EVWQEFIIEREIITKDGRIRYFEAVIVPLIDTDGSVKGILVILRDITEKKEAEELMARSEKLSIAGQLAAGIAHEIRNPL 302

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 563 TTLRGFLQLQQQTQSVNADHIDLMLSELDRINLIVSEFLILAKPQAIHFQERDVRGILRDVISFLDSQAHLYGVEVKLDF 642
Cdd:COG5805   303 TSIKGFLQLLQPGIEDKEEYFDIMLSELDRIESIISEFLALAKPQAVNKEKENINELIQDVVTLLETEAILHNIQIRLEL 382

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 643 SPEPALVHCEENQLKQVFINLLKNAFEAMPDGGTVTITLKrPGGDHVLITIQDEGHGIPEELMPHLGEPFITNKETGTGL 722
Cdd:COG5805   383 LDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTE-EEDNSVIIRVIDEGIGIPEERLKKLGEPFFTTKEKGTGL 461

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1148848711 723 GLMVSQRIIQGHQGTLEIESKSGVGTKISIVLP 755
Cdd:COG5805   462 GLMVSYKIIENHNGTIDIDSKVGKGTTFTITLP 494

PRK11360

two-component system sensor histidine kinase AtoS;

275-755

2.23e-89

two-component system sensor histidine kinase AtoS;

Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 293.41 E-value: 2.23e-89

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 275 RDAVSTGENVVLVDTIQGKKVLKSFIPIDYEDKptnVIGVVMDYEAISSVMRE--QM-ISLVAISLVLLEIVIFGSYIVA 351
Cdd:PRK11360  135 REVMRTNTPLVESGGQVRGGILNSMIPIERNGE---VIGYIWANELTEDIRRQawKMdRRIYAVLAAGLVIGLLLIFLLS 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 352 GYFtkpiqsiLRTVNDVADG------HFDRRLEVTsRDELGQLAGRINAMTRNLghytsqlkqmveenQSVKEYLESIIN 425
Cdd:PRK11360  212 RRF-------SANVDIIKDGlstlenDLSTRLPPL-PGELGEISQAINNLAQAL--------------RETRSLNELILE 269

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 426 QTADAIHTTDTHERVISVNNAFEQLYGWKANEVIGQKL-ELVPPSKLDEERDRLRRLREGERLPpvETVRMRKDGSLIEV 504
Cdd:PRK11360  270 SIADGVIAIDRQGKITTMNPAAEVITGLQRHELVGKPYsELFPPNTPFASPLLDTLEHGTEHVD--LEISFPGRDRTIEL 347

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 505 SISTSLVRDEQGQVTSMISVSRDVTERNRIEELLRRSEKLNTVGQLAAGVAHEIRNPLTTLRGFLQL--QQQTQSVNADH 582
Cdd:PRK11360  348 SVSTSLLHNTHGEMIGALVIFSDLTERKRLQRRVARQERLAALGELVAGVAHEIRNPLTAIRGYVQIwrQQTSDPPSQEY 427

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 583 IDLMLSELDRINLIVSEFLILAKPQAIHFQERDVRGILRDVISFLDSQAHLYGVEVKLDFSPEPALVHCEENQLKQVFIN 662
Cdd:PRK11360  428 LSVVLREVDRLNKVIDQLLEFSRPRESQWQPVSLNALVEEVLQLFQTAGVQARVDFETELDNELPPIWADPELLKQVLLN 507

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 663 LLKNAFEAMPDGGTVTITLKRPGGDHVLITIQDEGHGIPEELMPHLGEPFITNKETGTGLGLMVSQRIIQGHQGTLEIES 742
Cdd:PRK11360  508 ILINAVQAISARGKIRIRTWQYSDGQVAVSIEDNGCGIDPELLKKIFDPFFTTKAKGTGLGLALSQRIINAHGGDIEVES 587

                         490
                  ....*....|...
gi 1148848711 743 KSGVGTKISIVLP 755
Cdd:PRK11360  588 EPGVGTTFTLYLP 600

HATPase_c

smart00387

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.

653-755

9.13e-32

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.

Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 119.29 E-value: 9.13e-32

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711  653 ENQLKQVFINLLKNAFEAMPDGGTVTITLKRpGGDHVLITIQDEGHGIPEELMPHLGEPFITNKET-----GTGLGLMVS 727
Cdd:smart00387   3 PDRLRQVLSNLLDNAIKYTPEGGRITVTLER-DGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRsrkigGTGLGLSIV 81

                           90       100
                   ....*....|....*....|....*...
gi 1148848711  728 QRIIQGHQGTLEIESKSGVGTKISIVLP 755
Cdd:smart00387  82 KKLVELHGGEISVESEPGGGTTFTITLP 109

HATPase_c

pfam02518

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...

653-758

3.80e-29

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.

Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 111.69 E-value: 3.80e-29

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 653 ENQLKQVFINLLKNAFEAMPDGGTVTITLKRpgGDHVLITIQDEGHGIPEELMPHLGEPFITNKET---GTGLGLMVSQR 729
Cdd:pfam02518   3 ELRLRQVLSNLLDNALKHAAKAGEITVTLSE--GGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRgggGTGLGLSIVRK 80

                          90       100
                  ....*....|....*....|....*....
gi 1148848711 730 IIQGHQGTLEIESKSGVGTKISIVLPAAR 758
Cdd:pfam02518  81 LVELLGGTITVESEPGGGTTVTLTLPLAQ 109

HATPase_AtoS-like

cd16943

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

655-755

3.00e-28

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.

Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 109.05 E-value: 3.00e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 655 QLKQVFINLLKNAFEAMPDGGTVTItlkRPGG--DHVLITIQDEGHGIPEELMPHLGEPFITNKE--TGTGLGLMVSQRI 730
Cdd:cd16943     3 QLNQVLLNLLVNAAQAMEGRGRITI---RTWAhvDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPvgEGTGLGLSLSYRI 79

                          90       100
                  ....*....|....*....|....*
gi 1148848711 731 IQGHQGTLEIESKSGVGTKISIVLP 755
Cdd:cd16943    80 IQKHGGTIRVASVPGGGTRFTIILP 104

sensory_box

TIGR00229

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ...

418-538

8.53e-16

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]

Pssm-ID: 272971 [Multi-domain] Cd Length: 124 Bit Score: 74.25 E-value: 8.53e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 418 EYLESIINQTADAIHTTDTHERVISVNNAFEQLYGWKANEVIGQK-LELVPPSKLDEERDRLRRLREGERLPPVETVR-M 495
Cdd:TIGR00229   3 ERYRAIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSAEELIGRNvLELIPEEDREEVRERIERRLEGEPEPVSEERRvR 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1148848711 496 RKDGSLIEVSISTSLVRdEQGQVTSMISVSRDVTERNRIEELL 538
Cdd:TIGR00229  83 RKDGSEIWVEVSVSPIR-TNGGELGVVGIVRDITERKEAEEAL 124

HAMP

cd06225

Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ...

355-399

7.92e-13

Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 63.23 E-value: 7.92e-13

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1148848711 355 TKPIQSILRTVNDVADGHFDRRLEVTSRDELGQLAGRINAMTRNL 399
Cdd:cd06225     1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45

Tar

COG0840

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];

265-450

1.19e-12

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];

Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 71.20 E-value: 1.19e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 265 GKLDQDMEAVRDAVSTGENVVLVDTIQGKKVLKSFIPIDYEDKPTNVIGVVMDYEAISSVMREQMISLVAISLVLLEIVI 344
Cdd:COG0840   117 ELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALLEAAALALAAAALALALLAAALLALVALAI 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 345 FGSYIVAGYFTKPIQSILRTVNDVADGHFDRRLEVTSRDELGQLAGRINAMTRNLGHYTSQLKQMVEENQSVKEYLESII 424
Cdd:COG0840   197 ILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENLRELVGQVRESAEQVASASEELAASA 276

                         170       180
                  ....*....|....*....|....*.
gi 1148848711 425 NQTADAihTTDTHERVISVNNAFEQL 450
Cdd:COG0840   277 EELAAG--AEEQAASLEETAAAMEEL 300

HAMP

pfam00672

HAMP domain;

349-399

1.09e-10

HAMP domain;

Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 57.25 E-value: 1.09e-10

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1148848711 349 IVAGYFTKPIQSILRTVNDVADGHFDRRLEVTSRDELGQLAGRINAMTRNL 399
Cdd:pfam00672   1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERL 51

HAMP

smart00304

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;

353-399

4.52e-10

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;

Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 55.72 E-value: 4.52e-10

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1148848711  353 YFTKPIQSILRTVNDVADGHFDRRLEVTSRDELGQLAGRINAMTRNL 399
Cdd:smart00304   2 RLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRL 48

PRK10935

nitrate/nitrite two-component system sensor histidine kinase NarQ;

329-412

2.72e-04

nitrate/nitrite two-component system sensor histidine kinase NarQ;

Pssm-ID: 236800 [Multi-domain] Cd Length: 565 Bit Score: 44.46 E-value: 2.72e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 329 MISLVAISLV-LLEIVIFGSYIVagYFTK-----PIQSILRTVNDVADGHFDR-RLEVTSRDELGQLAGRINAMTRNLGH 401
Cdd:PRK10935  147 LILLAAISLLgLILILTLVFFTV--RFTRrqvvaPLNQLVTASQQIEKGQFDHiPLDTTLPNELGLLAKAFNQMSSELHK 224

                          90
                  ....*....|.
gi 1148848711 402 YTSQLKQMVEE 412
Cdd:PRK10935  225 LYRSLEASVEE 235

Name

Accession

Description

Interval

E-value

KinA

COG5805

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...

404-755

4.26e-128

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 391.02 E-value: 4.26e-128

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 404 SQLKQMVEENQSVKEYLESIINQTADAIHTTDTHERVISVNNAFEQLYGWKANEVIGQKL-ELVPPSKLDEERDRLRRLR 482
Cdd:COG5805   143 TKKKKIEEILQEQEERLQTLIENSPDLICVIDTDGRILFINESIERLFGAPREELIGKNLlELLHPCDKEEFKERIESIT 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 483 EGERLPPVETVRMRKDGSLIEVSISTSLVRDEQGQVTSMISVSRDVTERNRIEELLRRSEKLNTVGQLAAGVAHEIRNPL 562
Cdd:COG5805   223 EVWQEFIIEREIITKDGRIRYFEAVIVPLIDTDGSVKGILVILRDITEKKEAEELMARSEKLSIAGQLAAGIAHEIRNPL 302

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 563 TTLRGFLQLQQQTQSVNADHIDLMLSELDRINLIVSEFLILAKPQAIHFQERDVRGILRDVISFLDSQAHLYGVEVKLDF 642
Cdd:COG5805   303 TSIKGFLQLLQPGIEDKEEYFDIMLSELDRIESIISEFLALAKPQAVNKEKENINELIQDVVTLLETEAILHNIQIRLEL 382

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 643 SPEPALVHCEENQLKQVFINLLKNAFEAMPDGGTVTITLKrPGGDHVLITIQDEGHGIPEELMPHLGEPFITNKETGTGL 722
Cdd:COG5805   383 LDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTE-EEDNSVIIRVIDEGIGIPEERLKKLGEPFFTTKEKGTGL 461

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1148848711 723 GLMVSQRIIQGHQGTLEIESKSGVGTKISIVLP 755
Cdd:COG5805   462 GLMVSYKIIENHNGTIDIDSKVGKGTTFTITLP 494

KinE

COG5809

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...

404-755

1.63e-126

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 386.64 E-value: 1.63e-126

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 404 SQLKQMVEENQSVKEYLESIINQTADAIHTTDTHERVISVNNAFEQLYGWKANEVIGQKL-ELVPPSKLDEERDRLRRLR 482
Cdd:COG5809   127 TERKRMEEALRESEEKFRLIFNHSPDGIIVTDLDGRIIYANPAACKLLGISIEELIGKSIlELIHSDDQENVAAFISQLL 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 483 EGERLPPVETVRMRKDGSLIEVSISTSLVrDEQGQVTSMISVSRDVTERNRIEELLRRSEKLNTVGQLAAGVAHEIRNPL 562
Cdd:COG5809   207 KDGGIAQGEVRFWTKDGRWRLLEASGAPI-KKNGEVDGIVIIFRDITERKKLEELLRKSEKLSVVGELAAGIAHEIRNPL 285

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 563 TTLRGFLQLQQQTQSV-NADHIDLMLSELDRINLIVSEFLILAKPQAIHFQERDVRGILRDVISFLDSQAHLYGVEVKLD 641
Cdd:COG5809   286 TSLKGFIQLLKDTIDEeQKTYLDIMLSELDRIESIISEFLVLAKPQAIKYEPKDLNTLIEEVIPLLQPQALLKNVQIELE 365

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 642 FSPEPALVHCEENQLKQVFINLLKNAFEAMPDGGTVTITLKRPGGDHVLITIQDEGHGIPEELMPHLGEPFITNKETGTG 721
Cdd:COG5809   366 LEDDIPDILGDENQLKQVFINLLKNAIEAMPEGGNITIETKAEDDDKVVISVTDEGCGIPEERLKKLGEPFYTTKEKGTG 445

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1148848711 722 LGLMVSQRIIQGHQGTLEIESKSGVGTKISIVLP 755
Cdd:COG5809   446 LGLMVSYKIIEEHGGKITVESEVGKGTTFSITLP 479

NtrY

COG5000

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...

329-760

3.71e-112

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];

Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 346.95 E-value: 3.71e-112

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 329 MISLVAISLVLLEIVIFGSYIVAGYFTKPIQSILRTVNDVADGHFDRRLEVTSRDELGQLAGRINAMTRnlghytsQLKQ 408
Cdd:COG5000     8 LLLLLLIALLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTD-------QLKE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 409 MVEENQSVKEYLESIINQTADAIHTTDTHERVISVNNAFEQLYGWKANEVIGQKLELVPPSKLDEERDRLRRLREGErlp 488
Cdd:COG5000    81 QREELEERRRYLETILENLPAGVIVLDADGRITLANPAAERLLGIPLEELIGKPLEELLPELDLAELLREALERGWQ--- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 489 pvETVRMRKDGSLIeVSISTSLVRDEqGQVtsmiSVSRDVTErnrieelLRRSEKLNTVGQLAAGVAHEIRNPLTTLRGF 568
Cdd:COG5000   158 --EEIELTRDGRRT-LLVRASPLRDD-GYV----IVFDDITE-------LLRAERLAAWGELARRIAHEIKNPLTPIQLS 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 569 LQ-LQQQTQSVNAD-------HIDLMLSELDRINLIVSEFLILAKPQAIHFQERDVRGILRDVISFLDSQAHLYGVEVKL 640
Cdd:COG5000   223 AErLRRKLADKLEEdredlerALDTIIRQVDRLKRIVDEFLDFARLPEPQLEPVDLNELLREVLALYEPALKEKDIRLEL 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 641 DFSPEPALVHCEENQLKQVFINLLKNAFEAMPDGGTVTITLKRpGGDHVLITIQDEGHGIPEELMPHLGEPFITNKETGT 720
Cdd:COG5000   303 DLDPDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRR-EDGRVRIEVSDNGPGIPEEVLERIFEPFFTTKPKGT 381

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 1148848711 721 GLGLMVSQRIIQGHQGTLEIESKSGVGTKISIVLPAARRQ 760
Cdd:COG5000   382 GLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLAEEA 421

NtrB

COG3852

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];

414-762

1.02e-111

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];

Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 343.75 E-value: 1.02e-111

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 414 QSVKEYLESIINQTADAIHTTDTHERVISVNNAFEQLYGWKANEVIGQKLELVPPSKLDEERDRLRRLREGERLPPVETV 493
Cdd:COG3852     3 RESEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFPEDSPLRELLERALAEGQPVTEREVT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 494 RMRKDGSLIEVSISTSLVRDEQGQvTSMISVSRDVTERNRIEELLRRSEKLNTVGQLAAGVAHEIRNPLTTLRGFLQL-- 571
Cdd:COG3852    83 LRRKDGEERPVDVSVSPLRDAEGE-GGVLLVLRDITERKRLERELRRAEKLAAVGELAAGLAHEIRNPLTGIRGAAQLle 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 572 QQQTQSVNADHIDLMLSELDRINLIVSEFLILAKPQAIHFQERDVRGILRDVISFLDSQAHlYGVEVKLDFSPEPALVHC 651
Cdd:COG3852   162 RELPDDELREYTQLIIEEADRLNNLVDRLLSFSRPRPPEREPVNLHEVLERVLELLRAEAP-KNIRIVRDYDPSLPEVLG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 652 EENQLKQVFINLLKNAFEAMPDGGTVTITL---------KRPGGDHVLITIQDEGHGIPEELMPHLGEPFITNKETGTGL 722
Cdd:COG3852   241 DPDQLIQVLLNLVRNAAEAMPEGGTITIRTrverqvtlgGLRPRLYVRIEVIDNGPGIPEEILDRIFEPFFTTKEKGTGL 320

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1148848711 723 GLMVSQRIIQGHQGTLEIESKSGVGTKISIVLPAARRQSD 762
Cdd:COG3852   321 GLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQAEEE 360

KinC

COG5807

Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ...

406-755

4.93e-95

Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 300.16 E-value: 4.93e-95

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 406 LKQMVEENQSVKEYLESIinqtADAIHTTDTHERVISVNNAFEQLYGWKANEVIGQklelvpPSKLDEERDRLRRLREGE 485
Cdd:COG5807    19 FKLTEDSEFKFKQLFDSI----LEFVFFIDSKGEILECNDFAEDLYGLSQNEYIGK------TFVEEKCILKDEQLYNKE 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 486 RLPPVETVRMRKDGSLIEvsISTSLVRDeQGQVTSMISVSRDVTERNRIEELLRRSEKLNTVGQLAAGVAHEIRNPLTTL 565
Cdd:COG5807    89 AFDRIEISYLTKNGEFDE--IIYPIYYK-DGVILGLITVYRDITKRKEAEDKLLRSEKLSVAGELAAGIAHEIRNPLTSI 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 566 RGFLQLQQQ--TQSVNADHIDLMLSELDRINLIVSEFLILAKPQAIHFQERDVRGILRDVISFLDSQAHLYGVEVKLDFS 643
Cdd:COG5807   166 KGFLQLLQEsrEDSEREEYFNIIISEIDRINTIITELLVLSKPKKFNFKKLNLNDVLEDVIALLSTEAILKNISIKYDLA 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 644 PEPALVHCEENQLKQVFINLLKNAFEAMPDGGTVTITLKRPgGDHVLITIQDEGHGIPEELMPHLGEPFITNKETGTGLG 723
Cdd:COG5807   246 DDEPVINGDKNQLKQVFINLIKNAIEAMETGGNITIKTYVE-GDFVVISVKDEGIGIPEEVLEKIGEPFFTTKEEGTGLG 324

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1148848711 724 LMVSQRIIQGHQGTLEIESKSGVGTKISIVLP 755
Cdd:COG5807   325 LSICKKIIEEHNGTIEVESKPGKGTTFTIYLP 356

PRK11360

two-component system sensor histidine kinase AtoS;

275-755

2.23e-89

two-component system sensor histidine kinase AtoS;

Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 293.41 E-value: 2.23e-89

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 275 RDAVSTGENVVLVDTIQGKKVLKSFIPIDYEDKptnVIGVVMDYEAISSVMRE--QM-ISLVAISLVLLEIVIFGSYIVA 351
Cdd:PRK11360  135 REVMRTNTPLVESGGQVRGGILNSMIPIERNGE---VIGYIWANELTEDIRRQawKMdRRIYAVLAAGLVIGLLLIFLLS 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 352 GYFtkpiqsiLRTVNDVADG------HFDRRLEVTsRDELGQLAGRINAMTRNLghytsqlkqmveenQSVKEYLESIIN 425
Cdd:PRK11360  212 RRF-------SANVDIIKDGlstlenDLSTRLPPL-PGELGEISQAINNLAQAL--------------RETRSLNELILE 269

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 426 QTADAIHTTDTHERVISVNNAFEQLYGWKANEVIGQKL-ELVPPSKLDEERDRLRRLREGERLPpvETVRMRKDGSLIEV 504
Cdd:PRK11360  270 SIADGVIAIDRQGKITTMNPAAEVITGLQRHELVGKPYsELFPPNTPFASPLLDTLEHGTEHVD--LEISFPGRDRTIEL 347

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 505 SISTSLVRDEQGQVTSMISVSRDVTERNRIEELLRRSEKLNTVGQLAAGVAHEIRNPLTTLRGFLQL--QQQTQSVNADH 582
Cdd:PRK11360  348 SVSTSLLHNTHGEMIGALVIFSDLTERKRLQRRVARQERLAALGELVAGVAHEIRNPLTAIRGYVQIwrQQTSDPPSQEY 427

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 583 IDLMLSELDRINLIVSEFLILAKPQAIHFQERDVRGILRDVISFLDSQAHLYGVEVKLDFSPEPALVHCEENQLKQVFIN 662
Cdd:PRK11360  428 LSVVLREVDRLNKVIDQLLEFSRPRESQWQPVSLNALVEEVLQLFQTAGVQARVDFETELDNELPPIWADPELLKQVLLN 507

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 663 LLKNAFEAMPDGGTVTITLKRPGGDHVLITIQDEGHGIPEELMPHLGEPFITNKETGTGLGLMVSQRIIQGHQGTLEIES 742
Cdd:PRK11360  508 ILINAVQAISARGKIRIRTWQYSDGQVAVSIEDNGCGIDPELLKKIFDPFFTTKAKGTGLGLALSQRIINAHGGDIEVES 587

                         490
                  ....*....|...
gi 1148848711 743 KSGVGTKISIVLP 755
Cdd:PRK11360  588 EPGVGTTFTLYLP 600

KinB

COG5806

Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ...

530-757

3.73e-79

Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 260.18 E-value: 3.73e-79

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 530 ERNRIEELLRRSEKLNTVGQLAAGVAHEIRNPLTTLRGFLQLQQQTQSVNAD---HIDLMLSELDRINLIVSEFLILAKP 606
Cdd:COG5806   184 ENILLRKELQRAEKLEVVSELAASIAHEVRNPLTVVRGFIQLLQEPELSDEKrkqYIRIALEELDRAEAIITDYLTFAKP 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 607 QAIHFQERDVRGILRDVISFLDSQAHLYGVEVKLDFSPePALVHCEENQLKQVFINLLKNAFEAMPDGGTVTITLKRPGg 686
Cdd:COG5806   264 QPEKLEKIDVSEELEHVIDVLSPYANMNNVEIQTELEP-GLYIEGDRQKLQQCLINIIKNGIEAMPNGGTLTIDVSIDK- 341

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1148848711 687 DHVLITIQDEGHGIPEELMPHLGEPFITNKETGTGLGLMVSQRIIQGHQGTLEIESKSGVGTKISIVLPAA 757
Cdd:COG5806   342 NKVIISIKDTGVGMTKEQLERLGEPYFSTKEKGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITLPLA 412

COG4191

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...

526-757

2.07e-72

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];

Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 240.47 E-value: 2.07e-72

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 526 RDVTERNRIEELLRRSEKLNTVGQLAAGVAHEIRNPLTTLRGFLQL------QQQTQSVNADHIDLMLSELDRINLIVSE 599
Cdd:COG4191   121 RAEEELRELQEQLVQSEKLAALGELAAGIAHEINNPLAAILGNAELlrrrleDEPDPEELREALERILEGAERAAEIVRS 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 600 FLILAKPQAIHFQERDVRGILRDVISFLDSQAHLYGVEVKLDFSPEPALVHCEENQLKQVFINLLKNAFEAMPDG--GTV 677
Cdd:COG4191   201 LRAFSRRDEEEREPVDLNELIDEALELLRPRLKARGIEVELDLPPDLPPVLGDPGQLEQVLLNLLINAIDAMEEGegGRI 280

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 678 TITLkRPGGDHVLITIQDEGHGIPEELMPHLGEPFITNKET--GTGLGLMVSQRIIQGHQGTLEIESKSGVGTKISIVLP 755
Cdd:COG4191   281 TIST-RREGDYVVISVRDNGPGIPPEVLERIFEPFFTTKPVgkGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLP 359


                  ..
gi 1148848711 756 AA 757
Cdd:COG4191   360 LA 361

KinD

COG5808

Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ...

530-756

1.24e-65

Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];

Pssm-ID: 444510 [Multi-domain] Cd Length: 454 Bit Score: 225.40 E-value: 1.24e-65

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 530 ERNRIEELLRRSE--KLNTVGQLAAGVAHEIRNPLTTLRGFLQLQQQTQSVNAD--HIDLMLSELDRINLIVSEFLILAK 605
Cdd:COG5808   222 RKTLLERVIQEINtqKLELIGTFAASTAHEIRNPLTSIKGFIQLLQEKYPELEDqkYFDIIQEEIQRINQIVSEFLVLGK 301

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 606 PQAIHFQERDVRGILRDVISFLDSQAHLYGVEVKLDFSPEPALVHCEENQLKQVFINLLKNAFEAMPDGGTVTITLkRPG 685
Cdd:COG5808   302 PTAKKLELDDLNELIEEILSIIDSEANLKNIRVEKQSLDEPLHIKCDKDRIKQVLLNLIKNAIEAMKEGGKLTISI-END 380

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1148848711 686 GDHVLITIQDEGHGIPEELMPHLGEPFITNKETGTGLGLMVSQRIIQGHQGTLEIESKSGVGTKISIVLPA 756
Cdd:COG5808   381 DEKAVIEVIDNGEGIPEDIIDEIFEPFVTTKEGGTGLGLSVCKRIVEMHGGEIDIESEEGKGTTFTIRLPL 451

BaeS

COG0642

Signal transduction histidine kinase [Signal transduction mechanisms];

510-757

2.88e-61

Signal transduction histidine kinase [Signal transduction mechanisms];

Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 209.38 E-value: 2.88e-61

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 510 LVRDEQGQVTSMISVSRDVTERNRIEELLRRSEKLntVGQLAAGVAHEIRNPLTTLRGFLQ-LQQQTQSVNADHIDLMLS 588
Cdd:COG0642    75 LLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANEA--KSRFLANVSHELRTPLTAIRGYLElLLEELDEEQREYLETILR 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 589 ELDRINLIVSEFLILAKPQA----IHFQERDVRGILRDVISFLDSQAHLYGVEVKLDFSPEPALVHCEENQLKQVFINLL 664
Cdd:COG0642   153 SADRLLRLINDLLDLSRLEAgkleLEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLL 232

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 665 KNAFEAMPDGGTVTITLkRPGGDHVLITIQDEGHGIPEELMPHLGEPFITNKET----GTGLGLMVSQRIIQGHQGTLEI 740
Cdd:COG0642   233 SNAIKYTPEGGTVTVSV-RREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSrrggGTGLGLAIVKRIVELHGGTIEV 311

                         250
                  ....*....|....*..
gi 1148848711 741 ESKSGVGTKISIVLPAA 757
Cdd:COG0642   312 ESEPGKGTTFTVTLPLA 328

KdpD

COG2205

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];

533-758

2.29e-57

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];

Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 195.51 E-value: 2.29e-57

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 533 RIEELLRRSEKLNTV-GQLAAGVAHEIRNPLTTLRGFLQLQQQTQSVN----ADHIDLMLSELDRINLIVSEFLILAKPQ 607
Cdd:COG2205     1 ELEEALEELEELERLkSEFLANVSHELRTPLTSILGAAELLLDEEDLSpeerRELLEIIRESAERLLRLIEDLLDLSRLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 608 A----IHFQERDVRGILRDVISFLDSQAHLYGVEVKLDFSPEPALVHCEENQLKQVFINLLKNAFEAMPDGGTVTITLKR 683
Cdd:COG2205    81 SgklsLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARR 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1148848711 684 pGGDHVLITIQDEGHGIPEELMPHLGEPF----ITNKETGTGLGLMVSQRIIQGHQGTLEIESKSGVGTKISIVLPAAR 758
Cdd:COG2205   161 -EGDGVRISVSDNGPGIPEEELERIFERFyrgdNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAE 238

WalK

COG5002

Sensor histidine kinase WalK [Signal transduction mechanisms];

511-758

3.92e-56

Sensor histidine kinase WalK [Signal transduction mechanisms];

Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 197.47 E-value: 3.92e-56

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 511 VRDEQGQVTSMISVSRDVTERNRIEELLRrseklntvgQLAAGVAHEIRNPLTTLRGFLQL----QQQTQSVNADHIDLM 586
Cdd:COG5002   138 LSALLLGLLLLAAVERDITELERLEQMRR---------EFVANVSHELRTPLTSIRGYLELlldgAADDPEERREYLEII 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 587 LSELDRINLIVSEFLILAKPQA----IHFQERDVRGILRDVISFLDSQAHLYGVEVKLDFSPEPALVHCEENQLKQVFIN 662
Cdd:COG5002   209 LEEAERLSRLVNDLLDLSRLESgelkLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPLLVLGDPDRLEQVLTN 288

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 663 LLKNAFEAMPDGGTVTITLKRpGGDHVLITIQDEGHGIPEELMPHLGEPF------ITNKETGTGLGLMVSQRIIQGHQG 736
Cdd:COG5002   289 LLDNAIKYTPEGGTITVSLRE-EDDQVRISVRDTGIGIPEEDLPRIFERFyrvdksRSRETGGTGLGLAIVKHIVEAHGG 367

                         250       260
                  ....*....|....*....|..
gi 1148848711 737 TLEIESKSGVGTKISIVLPAAR 758
Cdd:COG5002   368 RIWVESEPGKGTTFTITLPLAR 389

PRK10364

two-component system sensor histidine kinase ZraS;

531-764

1.08e-48

two-component system sensor histidine kinase ZraS;

Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 178.44 E-value: 1.08e-48

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 531 RNRIEELLRRSEKLNTVGQLAAGVAHEIRNPLTTLRGFLQ-LQQQTQSVNADH--IDLMLSELDRINLIVSEFLILAKPQ 607
Cdd:PRK10364  221 RQLLQDEMKRKEKLVALGHLAAGVAHEIRNPLSSIKGLAKyFAERAPAGGEAHqlAQVMAKEADRLNRVVSELLELVKPT 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 608 AIHFQERDVRGILRDVISFLDSQAHLYGVEVKLDFSPEPALVHCEENQLKQVFINLLKNAFEAMPDGGTVTITLKRpGGD 687
Cdd:PRK10364  301 HLALQAVDLNDLINHSLQLVSQDANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASE-SGA 379

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1148848711 688 HVLITIQDEGHGIPEELMPHLGEPFITNKETGTGLGLMVSQRIIQGHQGTLEIESKSGVGTKISIVLPAARRQSDME 764
Cdd:PRK10364  380 GVKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVNITRRDPQ 456

PRK13837

two-component system VirA-like sensor kinase;

522-761

3.44e-44

two-component system VirA-like sensor kinase;

Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 171.40 E-value: 3.44e-44

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 522 ISVSRDVTERNRIEELLRRSEKLNTVGQLAAGVAHEIRNPLTTLRGFLQLQQ---QTQSVNADHIDLMLSELDRINLIVS 598
Cdd:PRK13837  425 IERRRLETERDALERRLEHARRLEAVGTLASGIAHNFNNILGAILGYAEMALnklARHSRAARYIDEIISAGARARLIID 504

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 599 EFLILAKPQAIHFQERDVRGILRDVISFLdSQAHLYGVEVKLDFSPEPALVHCEENQLKQVFINLLKNAFEAMPDGGTVT 678
Cdd:PRK13837  505 QILAFGRKGERNTKPFDLSELVTEIAPLL-RVSLPPGVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVD 583

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 679 ITLKR--------------PGGDHVLITIQDEGHGIPEELMPHLGEPFITNKETGTGLGLMVSQRIIQGHQGTLEIESKS 744
Cdd:PRK13837  584 ISLSRaklrapkvlshgvlPPGRYVLLRVSDTGAGIDEAVLPHIFEPFFTTRAGGTGLGLATVHGIVSAHAGYIDVQSTV 663

                         250
                  ....*....|....*..
gi 1148848711 745 GVGTKISIVLPAARRQS 761
Cdd:PRK13837  664 GRGTRFDVYLPPSSKVP 680

HATPase_c

smart00387

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.

653-755

9.13e-32

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.

Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 119.29 E-value: 9.13e-32

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711  653 ENQLKQVFINLLKNAFEAMPDGGTVTITLKRpGGDHVLITIQDEGHGIPEELMPHLGEPFITNKET-----GTGLGLMVS 727
Cdd:smart00387   3 PDRLRQVLSNLLDNAIKYTPEGGRITVTLER-DGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRsrkigGTGLGLSIV 81

                           90       100
                   ....*....|....*....|....*...
gi 1148848711  728 QRIIQGHQGTLEIESKSGVGTKISIVLP 755
Cdd:smart00387  82 KKLVELHGGEISVESEPGGGTTFTITLP 109

PRK13557

histidine kinase; Provisional

440-765

6.57e-31

histidine kinase; Provisional

Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 128.25 E-value: 6.57e-31

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 440 VISVNNAFEQLYGWKANEVIGQKLE-LVPPSKLDEERDRLRRLREGERLPPVETVRMRKDGSLIEVSISTSLVRDEQGQV 518
Cdd:PRK13557   55 IVFANRAFLEMTGYAAEEIIGNNCRfLQGPETDRATVAEVRDAIAERREIATEILNYRKDGSSFWNALFVSPVYNDAGDL 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 519 TSMISVSRDVTERNRIEELLRRSEKLNTVGQLAAGVAHEIRNPLTTLRGFLQLQQQTQSVNADHIDLMLSELDRINLIVS 598
Cdd:PRK13557  135 VYFFGSQLDVSRRRDAEDALRQAQKMEALGQLTGGIAHDFNNLLQVMSGYLDVIQAALSHPDADRGRMARSVENIRAAAE 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 599 EFLILAKpQAIHF---QERDVRGI-LRDVISFLDSQA-HLYGVEVKLDFSPEPALVHCE--ENQLKQVFINLLKNAFEAM 671
Cdd:PRK13557  215 RAATLTQ-QLLAFarkQRLEGRVLnLNGLVSGMGELAeRTLGDAVTIETDLAPDLWNCRidPTQAEVALLNVLINARDAM 293

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 672 PDGGTVTITLKR--------------PGGDHVLITIQDEGHGIPEELMPHLGEPFITNKE--TGTGLGL-MVSQRIIQGh 734
Cdd:PRK13557  294 PEGGRVTIRTRNveiededlamyhglPPGRYVSIAVTDTGSGMPPEILARVMDPFFTTKEegKGTGLGLsMVYGFAKQS- 372

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1148848711 735 QGTLEIESKSGVGTKISIVLPAARRQSDMEA 765
Cdd:PRK13557  373 GGAVRIYSEVGEGTTVRLYFPASDQAENPEQ 403

HATPase_c

pfam02518

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...

653-758

3.80e-29

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.

Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 111.69 E-value: 3.80e-29

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 653 ENQLKQVFINLLKNAFEAMPDGGTVTITLKRpgGDHVLITIQDEGHGIPEELMPHLGEPFITNKET---GTGLGLMVSQR 729
Cdd:pfam02518   3 ELRLRQVLSNLLDNALKHAAKAGEITVTLSE--GGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRgggGTGLGLSIVRK 80

                          90       100
                  ....*....|....*....|....*....
gi 1148848711 730 IIQGHQGTLEIESKSGVGTKISIVLPAAR 758
Cdd:pfam02518  81 LVELLGGTITVESEPGGGTTVTLTLPLAQ 109

COG4251

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...

269-759

6.91e-29

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];

Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 121.43 E-value: 6.91e-29

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 269 QDMEAVRDAVSTGENVVLVDTIQGKKVLKSFIPIDYEDKPTNVIGVVMDYEAISSVMREQMISLVAISLVLLEIVIFGSY 348
Cdd:COG4251    15 LLLLLLLLLLLLVLLLALALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLLLLELALVLL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 349 IVAGYFTKPIQSILRTVNDVADGHFDRRLEVTSRDELGQLAGRINAMTRNLGHYTSQLKQMVEENQSVKEYLESIINQTA 428
Cdd:COG4251    95 ALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAA 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 429 DAIHTTDTHERVISVNNAFEQLYGWKANEVIGQKLELVPPSKLDEERDRLRRLREGERLPPVETVRMRKDGSLIEVSIST 508
Cdd:COG4251   175 LAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLEL 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 509 SLVRDEQGQVTsmisvsRDVTERNriEELLRRSEKLNtvgQLAAGVAHEIRNPLTTLRGFLQ-LQQQTQSV----NADHI 583
Cdd:COG4251   255 LELRLELEELE------EELEERT--AELERSNEELE---QFAYVASHDLREPLRKISGFSQlLEEDYGDKldeeGREYL 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 584 DLMLSELDRINLIVSEFLILAK--PQAIHFQERDVRGILRDVISFLDSQAHLYGVEVKLDFSPEpalVHCEENQLKQVFI 661
Cdd:COG4251   324 ERIRDAAERMQALIDDLLAYSRvgRQELEFEPVDLNELLEEVLEDLEPRIEERGAEIEVGPLPT---VRGDPTLLRQVFQ 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 662 NLLKNAFEAMPDGGTVTITLK-RPGGDHVLITIQDEGHGIPEELMPHLGEPFIT----NKETGTGLGLMVSQRIIQGHQG 736
Cdd:COG4251   401 NLISNAIKYSRPGEPPRIEIGaEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRlhsrDEYEGTGIGLAIVKKIVERHGG 480

                         490       500
                  ....*....|....*....|...
gi 1148848711 737 TLEIESKSGVGTKISIVLPAARR 759
Cdd:COG4251   481 RIWVESEPGEGATFYFTLPKAPA 503

CitA

COG3290

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...

401-759

6.98e-29

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];

Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 119.57 E-value: 6.98e-29

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 401 HYTSQLKQMVEENQSVKEYLESIINQTADAIHTTDTHERVISVNNAFEQLYGWkanEVIGQKLELVPPSKLDEERDRLRR 480
Cdd:COG3290    67 LLAALLLKLLEEIARLVEEREAVLESIREGVIAVDRDGRITLINDAARRLLGL---DAIGRPIDEVLAEVLETGERDEEI 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 481 LREGerlppvetvrmrkdgslIEVSISTSLVRDEqGQVTSMISVSRDVTERNRIEELLRRSEKLNTVgqLAAgVAHEIRN 560
Cdd:COG3290   144 LLNG-----------------RVLVVNRVPIRDD-GRVVGAVATFRDRTELERLEEELEGVKELAEA--LRA-QRHDFRN 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 561 PLTTLRGFLQLQQQTQSVnaDHIDLMLSELDRINLIVSeflilakpqaIHFQERDVRGILRDVISfldsQAHLYGVEVKL 640
Cdd:COG3290   203 HLHTISGLLQLGEYDEAL--EYIDEISEELQELIDSLL----------SRIGNPVLAALLLGKAA----RARERGIDLTI 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 641 DFSPEPALVHCEENQLKQVFINLLKNAFEAM----PDGGTVTITLkRPGGDHVLITIQDEGHGIPEELMPHLGEP-FITN 715
Cdd:COG3290   267 DIDSDLPDLPLSDTDLVTILGNLLDNAIEAVeklpEEERRVELSI-RDDGDELVIEVEDSGPGIPEELLEKIFERgFSTK 345

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1148848711 716 KETGTGLGLMVSQRIIQGHQGTLEIESKSGVGTKISIVLPAARR 759
Cdd:COG3290   346 LGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEGE 389

HATPase_AtoS-like

cd16943

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

655-755

3.00e-28

Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 109.05 E-value: 3.00e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 655 QLKQVFINLLKNAFEAMPDGGTVTItlkRPGG--DHVLITIQDEGHGIPEELMPHLGEPFITNKE--TGTGLGLMVSQRI 730
Cdd:cd16943     3 QLNQVLLNLLVNAAQAMEGRGRITI---RTWAhvDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPvgEGTGLGLSLSYRI 79

                          90       100
                  ....*....|....*....|....*
gi 1148848711 731 IQGHQGTLEIESKSGVGTKISIVLP 755
Cdd:cd16943    80 IQKHGGTIRVASVPGGGTRFTIILP 104

PAS

COG2202

PAS domain [Signal transduction mechanisms];

411-561

9.13e-27

PAS domain [Signal transduction mechanisms];

Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 110.11 E-value: 9.13e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 411 EENQSVKEYLESIINQTADAIHTTDTHERVISVNNAFEQLYGWKANEVIGQKL-ELVPPSKLDEERDRLRRLREGERLPP 489
Cdd:COG2202     4 EALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLrDLLPPEDDDEFLELLRAALAGGGVWR 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1148848711 490 VETVRMRKDGSLIEVSISTSLVRDEQGQVTSMISVSRDVTERNRIEELLRRSEKLNTVGQLAAGVAHEIRNP 561
Cdd:COG2202    84 GELRNRRKDGSLFWVELSISPVRDEDGEITGFVGIARDITERKRAEEALRESEERLRLLVENAPDGIFVLDL 155

PRK11100

sensory histidine kinase CreC; Provisional

555-758

4.63e-24

sensory histidine kinase CreC; Provisional

Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 106.47 E-value: 4.63e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 555 AHEIRNPLTTLRGFLQLQQQTQSVN-----ADHIDlmlSELDRINLIVSEFLILAK---PQAIHFQER-DVRGILRDVIS 625
Cdd:PRK11100  264 THELKSPLAAIRGAAELLQEDPPPEdrarfTGNIL---TQSARLQQLIDRLLELARleqRQELEVLEPvALAALLEELVE 340

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 626 FLDSQAHLYGVEVKLDfsPEPALVHCEENQLKQVFINLLKNAFEAMPDGGTVTITLkRPGGDHVLITIQDEGHGIPEELM 705
Cdd:PRK11100  341 AREAQAAAKGITLRLR--PDDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSA-EVDGEQVALSVEDQGPGIPDYAL 417

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1148848711 706 PHLGEPFIT-----NKETGTGLGLMVSQRIIQGHQGTLEIESKSGVGTKISIVLPAAR 758
Cdd:PRK11100  418 PRIFERFYSlprpaNGRKSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPRHF 475

phoR

PRK11006

phosphate regulon sensor histidine kinase PhoR;

524-756

6.23e-24

phosphate regulon sensor histidine kinase PhoR;

Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 105.48 E-value: 6.23e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 524 VSRDVTERNRIEELlRRSeklntvgqLAAGVAHEIRNPLTTLRGFLQLQQQ---TQSVNADHIDLMLSELDRINLIVSEF 600
Cdd:PRK11006  190 VARDVTQMHQLEGA-RRN--------FFANVSHELRTPLTVLQGYLEMMQDqplEGALREKALHTMREQTQRMEGLVKQL 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 601 LILAKPQA---IHFQER-DVRGILRdvisFLDSQAH-LYGVEVKLDFSPEPAL-VHCEENQLKQVFINLLKNAFEAMPDG 674
Cdd:PRK11006  261 LTLSKIEAaptIDLNEKvDVPMMLR----VLEREAQtLSQGKHTITFEVDNSLkVFGNEDQLRSAISNLVYNAVNHTPEG 336

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 675 GTVTITLKR-PGGdhVLITIQDEGHGIPEELMPHLGEPFIT-----NKETG-TGLGLMVSQRIIQGHQGTLEIESKSGVG 747
Cdd:PRK11006  337 THITVRWQRvPQG--AEFSVEDNGPGIAPEHIPRLTERFYRvdkarSRQTGgSGLGLAIVKHALSHHDSRLEIESEVGKG 414


                  ....*....
gi 1148848711 748 TKISIVLPA 756
Cdd:PRK11006  415 TRFSFVLPE 423

COG4192

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...

528-742

2.51e-23

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];

Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 105.54 E-value: 2.51e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 528 VTERNRIEELLRRSE-------KLNTVGQLAAGVAHEIRNPLTTLRGFL-----QLQQQTQSVNADHIDLMLSELDRINL 595
Cdd:COG4192   407 IEERKRIEKNLRQTQdeliqaaKMAVVGQTMTSLAHELNQPLNAMSMYLfsakkALEQENYAQLPTSLDKIEGLIERMDK 486

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 596 IVSEFLILAKPQAIHFQERDVRGILRDVISFLDSQAHLYGVEVKLdfsPEPALVHCEENQLKQVFINLLKNAFEAMPDGG 675
Cdd:COG4192   487 IIKSLRQFSRKSDTPLQPVDLRQVIEQAWELVESRAKPQQITLHI---PDDLMVQGDQVLLEQVLVNLLVNALDAVATQP 563

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1148848711 676 TVTITLKRPGGDHVlITIQDEGHGIPeeLMPHLGEPFITNKETGTGLGLMVSQRIIQGHQGTLEIES 742
Cdd:COG4192   564 QISVDLLSNAENLR-VAISDNGNGWP--LVDKLFTPFTTTKEVGLGLGLSICRSIMQQFGGDLYLAS 627

glnL

PRK11073

nitrogen regulation protein NR(II);

510-755

4.60e-23

nitrogen regulation protein NR(II);

Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 101.31 E-value: 4.60e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 510 LVRDEQGQVTSMiSVSRdVTERNRIEELL-----RR--SEKLNTVGQLAA-----GVAHEIRNPLTTLRGFLQLQQQTQS 577
Cdd:PRK11073   83 LVIDGRSHILSL-TAQR-LPEGMILLEMApmdnqRRlsQEQLQHAQQVAArdlvrGLAHEIKNPLGGLRGAAQLLSKALP 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 578 VNA--DHIDLMLSELDRINLIVSEFLILAKP-----QAIHFQERDVRGILRdvisfLDSQahlYGVEVKLDFSPE-PALV 649
Cdd:PRK11073  161 DPAltEYTKVIIEQADRLRNLVDRLLGPQRPgthvtESIHKVAERVVQLVS-----LELP---DNVRLIRDYDPSlPELA 232

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 650 HcEENQLKQVFINLLKNAFEAM-PDGGTVTI--------TLKrpGGDHVL---ITIQDEGHGIPEELMPHLGEPFITNKE 717
Cdd:PRK11073  233 H-DPDQIEQVLLNIVRNALQALgPEGGTITLrtrtafqlTLH--GERYRLaarIDIEDNGPGIPPHLQDTLFYPMVSGRE 309

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1148848711 718 TGTGLGLMVSQRIIQGHQGTLEIESKSGvGTKISIVLP 755
Cdd:PRK11073  310 GGTGLGLSIARNLIDQHSGKIEFTSWPG-HTEFSVYLP 346

envZ

PRK09467

osmolarity sensor protein; Provisional

550-755

9.76e-23

osmolarity sensor protein; Provisional

Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 101.91 E-value: 9.76e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 550 LAAGVAHEIRNPLTTLR----------GFLQlqqqtQSVNADhIDLMlseldriNLIVSEFLILAKP-QAIHFQERDVRG 618
Cdd:PRK09467  232 LMAGVSHDLRTPLTRIRlatemmseedGYLA-----ESINKD-IEEC-------NAIIEQFIDYLRTgQEMPMEMADLNA 298

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 619 ILRDVISfldSQAHlYGVEVKLDFSPEPALVHCEENQLKQVFINLLKNAFEAmpDGGTVTITLKRpGGDHVLITIQDEGH 698
Cdd:PRK09467  299 LLGEVIA---AESG-YEREIETALQPGPIEVPMNPIAIKRALANLVVNAARY--GNGWIKVSSGT-EGKRAWFQVEDDGP 371

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1148848711 699 GIPEELMPHLGEPFiTNKET-----GTGLGLMVSQRIIQGHQGTLEIESKSGVGTKISIVLP 755
Cdd:PRK09467  372 GIPPEQLKHLFQPF-TRGDSargssGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLP 432

HATPase_TmoS-FixL-DctS-like

cd16920

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

656-755

1.01e-22

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.

Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 93.23 E-value: 1.01e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 656 LKQVFINLLKNAFEAM----PDGGTVTITLKRPGGDHVLITIQDEGHGIPEELMPHLGEPFITNKETGTGLGLMVSQRII 731
Cdd:cd16920     1 IQQVLINLVRNGIEAMseggCERRELTIRTSPADDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKSEGLGMGLSICRSII 80

                          90       100
                  ....*....|....*....|....
gi 1148848711 732 QGHQGTLEIESKSGVGTKISIVLP 755
Cdd:cd16920    81 EAHGGRLSVESPAGGGATFQFTLP 104

HATPase_Glnl-NtrB-like

cd16918

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

656-755

2.21e-22

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).

Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 92.46 E-value: 2.21e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 656 LKQVFINLLKNAFEAMPD-GGTVTI--------TLKRPGGDHVL-ITIQDEGHGIPEELMPHLGEPFITNKETGTGLGLM 725
Cdd:cd16918     1 LIQVFLNLVRNAAQALAGsGGEIILrtrtqrqvTLGHPRHRLALrVSVIDNGPGIPPDLQDTIFYPMVSGRENGTGLGLA 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1148848711 726 VSQRIIQGHQGTLEIESKSGvGTKISIVLP 755
Cdd:cd16918    81 IAQNIVSQHGGVIECDSQPG-HTVFSVSLP 109

PRK10755

two-component system sensor histidine kinase PmrB;

537-762

6.10e-22

two-component system sensor histidine kinase PmrB;

Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 98.12 E-value: 6.10e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 537 LLRRSEKLNTVGQLAAGVAHEIRNPLTTLRGFLQLQQQTQSVNAdhiDLMLSELDRINLIVSEFLILAKP-QAI---HFQ 612
Cdd:PRK10755  127 VSRLTSTLDQERLFTADVAHELRTPLAGIRLHLELLEKQHHIDV---APLIARLDQMMHTVEQLLQLARAgQSFssgHYQ 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 613 ERDvrgILRDVI----SFLDSQAHLYGVEVKLDFSPEPALVHCEENQLKQVFINLLKNAFEAMPDGGTVTITLKRPGGDH 688
Cdd:PRK10755  204 TVK---LLEDVIlpsqDELSEMLEQRQQTLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGA 280

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1148848711 689 VLiTIQDEGHGIPEELMPHLGEPF--ITNKETGTGLGLMVSQRIIQGHQGTLEIESKS-GVGTKISIVLPAARRQSD 762
Cdd:PRK10755  281 VL-AVEDEGPGIDESKCGELSKAFvrMDSRYGGIGLGLSIVSRITQLHHGQFFLQNRQeRSGTRAWVWLPKAQNVAN 356

HATPase_EvgS-ArcB-TorS-like

cd16922

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...

656-755

7.96e-22

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.

Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 91.02 E-value: 7.96e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 656 LKQVFINLLKNA--FEampDGGTVTITLKR----PGGDHVLITIQDEGHGIPEELMPHLGEPF------ITNKETGTGLG 723
Cdd:cd16922     1 LRQILLNLLGNAikFT---EEGEVTLRVSLeeeeEDGVQLRFSVEDTGIGIPEEQQARLFEPFsqadssTTRKYGGTGLG 77

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1148848711 724 LMVSQRIIQGHQGTLEIESKSGVGTKISIVLP 755
Cdd:cd16922    78 LAISKKLVELMGGDISVESEPGQGSTFTFTLP 109

HATPase_NtrY-like

cd16944

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

655-755

5.53e-20

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.

Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 85.67 E-value: 5.53e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 655 QLKQVFINLLKNAFEAM---PDG-GTVTITLKRPGGDHVLITIQDEGHGIPEELMPHLGEPFITNKETGTGLGLMVSQRI 730
Cdd:cd16944     4 QISQVLTNILKNAAEAIegrPSDvGEVRIRVEADQDGRIVLIVCDNGKGFPREMRHRATEPYVTTRPKGTGLGLAIVKKI 83

                          90       100
                  ....*....|....*....|....*
gi 1148848711 731 IQGHQGTLEIESKSGVGTKISIVLP 755
Cdd:cd16944    84 MEEHGGRISLSNREAGGACIRIILP 108

PRK09303

histidine kinase;

514-747

6.78e-20

histidine kinase;

Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 92.32 E-value: 6.78e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 514 EQGQVTSMISVSRDVTERNRIEE---LLRR-----SEKLNTVGQLAAGVAHEIRNPLTTLRGFLQLQQQTQSVNADHIDL 585
Cdd:PRK09303  110 GENLQPSEIDSGRYSQELLQLSDelfVLRQenetlLEQLKFKDRVLAMLAHDLRTPLTAASLALETLELGQIDEDTELKP 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 586 ML---------SELDRINLIVSEFLILAKPQA----IHFQERDVRGILRDVISFLDSQAHLYGVEVKLDFSPEPALVHCE 652
Cdd:PRK09303  190 ALieqlqdqarRQLEEIERLITDLLEVGRTRWealrFNPQKLDLGSLCQEVILELEKRWLAKSLEIQTDIPSDLPSVYAD 269

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 653 ENQLKQVFINLLKNAFEAMPDGGTVTITLKRPGGDHVLITIQDEGHGIPEELMPHLGEPFI----TNKETGTGLGLMVSQ 728
Cdd:PRK09303  270 QERIRQVLLNLLDNAIKYTPEGGTITLSMLHRTTQKVQVSICDTGPGIPEEEQERIFEDRVrlprDEGTEGYGIGLSVCR 349

                         250
                  ....*....|....*....
gi 1148848711 729 RIIQGHQGTLEIESKSGVG 747
Cdd:PRK09303  350 RIVRVHYGQIWVDSEPGQG 368

HATPase_CckA-like

cd16919

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...

656-755

6.95e-20

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).

Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 85.51 E-value: 6.95e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 656 LKQVFINLLKNAFEAMPDGGTVTITLKR--------------PGGDHVLITIQDEGHGIPEELMPHLGEPFITNKE--TG 719
Cdd:cd16919     1 LELAILNLAVNARDAMPEGGRLTIETSNqrvdadyalnyrdlIPGNYVCLEVSDTGSGMPAEVLRRAFEPFFTTKEvgKG 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1148848711 720 TGLGLMVSQRIIQGHQGTLEIESKSGVGTKISIVLP 755
Cdd:cd16919    81 TGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116

PRK10604

sensor protein RstB; Provisional

549-755

7.56e-19

sensor protein RstB; Provisional

Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 90.05 E-value: 7.56e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 549 QLAAGVAHEIRNPLTTLRGFLQL-----QQQTQSVNADhidlmlseLDRINLIVSEFLILA---KPQA-IHFQERDVRGI 619
Cdd:PRK10604  214 QLIDGIAHELRTPLVRLRYRLEMsdnlsAAESQALNRD--------IGQLEALIEELLTYArldRPQNeLHLSEPDLPAW 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 620 LRDVISFLDSQAHlyGVEVKLDFSPEPALVHCEENQLKQVFINLLKNAFEAMpdGGTVTITLKRPGgDHVLITIQDEGHG 699
Cdd:PRK10604  286 LSTHLADIQAVTP--EKTVRLDTPHQGDYGALDMRLMERVLDNLLNNALRYA--HSRVRVSLLLDG-NQACLIVEDDGPG 360

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1148848711 700 IPEELMPHLGEPFI------TNKETGTGLGLMVSQRIIQGHQGTLEIESKSGVGTKISIVLP 755
Cdd:PRK10604  361 IPPEERERVFEPFVrldpsrDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWP 422

HATPase_HupT_MifS-like

cd16976

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

656-754

1.45e-18

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.

Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 81.35 E-value: 1.45e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 656 LKQVFINLLKNAFEAMPD--GGTVTITLKRPGGDHVLiTIQDEGHGIPEELMPHLGEPFITNKET--GTGLGLMVSQRII 731
Cdd:cd16976     1 IQQVLMNLLQNALDAMGKveNPRIRIAARRLGGRLVL-VVRDNGPGIAEEHLSRVFDPFFTTKPVgkGTGLGLSISYGIV 79

                          90       100
                  ....*....|....*....|...
gi 1148848711 732 QGHQGTLEIESKSGVGTKISIVL 754
Cdd:cd16976    80 EEHGGRLSVANEEGAGARFTFDL 102

PRK09959

acid-sensing system histidine kinase EvgS;

526-755

6.97e-18

acid-sensing system histidine kinase EvgS;

Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 88.64 E-value: 6.97e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711  526 RDVTE-RNRIEEL-LRRSEKLNTV---GQLAAGVAHEIRNPLTTLRGFLQLQQ-----QTQSVNAdhIDLMLSELDRINL 595
Cdd:PRK09959   686 QDITEtRDLIHALeVERNKAINATvakSQFLATMSHEIRTPISSIMGFLELLSgsglsKEQRVEA--ISLAYATGQSLLG 763

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711  596 IVSEFLILAKPQAIHFQerdVRGILRDVISFLDSQAHLYGV-----EVKLDFS---PEPALVHCEENQLKQVFINLLKNA 667
Cdd:PRK09959   764 LIGEILDVDKIESGNYQ---LQPQWVDIPTLVQNTCHSFGAiaaskSIALSCSstfPDHYLVKIDPQAFKQVLSNLLSNA 840

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711  668 FEAMPDGGT-VTITLKRPGGDHVLI--TIQDEGHGIPEE----LMPHLGEPFITNKETGTGLGLMVSQRIIQGHQGTLEI 740
Cdd:PRK09959   841 LKFTTEGAVkITTSLGHIDDNHAVIkmTIMDSGSGLSQEeqqqLFKRYSQTSAGRQQTGSGLGLMICKELIKNMQGDLSL 920

                          250
                   ....*....|....*
gi 1148848711  741 ESKSGVGTKISIVLP 755
Cdd:PRK09959   921 ESHPGIGTTFTITIP 935

PRK09835

Cu(+)/Ag(+) sensor histidine kinase;

533-757

6.61e-17

Cu(+)/Ag(+) sensor histidine kinase;

Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 84.44 E-value: 6.61e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 533 RIEELLRRSeklntvGQLAAGVAHEIRNPLTTLRGFLQL---QQQTQSVNADHIDLMLSELDRINLIVSEFLILAkpQAI 609
Cdd:PRK09835  254 RIEDVFTRQ------SNFSADIAHEIRTPITNLITQTEIalsQSRSQKELEDVLYSNLEELTRMAKMVSDMLFLA--QAD 325

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 610 HFQ---ER---DVRGILRDVISFLDSQAHLYGVEVKLDFSPepALVHCEENQLKQVFINLLKNAFEAMPDGGTVTITLKR 683
Cdd:PRK09835  326 NNQlipEKkmlDLADEVGKVFDFFEAWAEERGVELRFVGDP--CQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQE 403

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 684 PgGDHVLITIQDEGHGIPEELMPHLGEPFI------TNKETGTGLGLMVSQRIIQGHQGTLEIESKSgVGTKISIVLPAA 757
Cdd:PRK09835  404 V-DHQVQLVVENPGTPIAPEHLPRLFDRFYrvdpsrQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDA-RGTRFVISLPRL 481

PRK15347

two component system sensor kinase;

539-755

6.68e-17

two component system sensor kinase;

Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 85.46 E-value: 6.68e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 539 RRSEKLNTVgqlaagvAHEIRNPLTTLRGFLQLQQQTQSvNADHIDLM-------LSELDRINLIVSEFLILAKPQAIHF 611
Cdd:PRK15347  397 RKSEHLTTI-------SHEIRTPLNGVLGALELLQNTPL-TAEQMDLAdtarqctLSLLAIINNLLDFSRIESGQMTLSL 468

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 612 QERDVRGILRDVISFLDSQAHLYGVEVKLDFSPE-PALVHCEENQLKQVFINLLKNAFEAMPDGGtVTITLKRPGgDHVL 690
Cdd:PRK15347  469 EETALLPLLDQAMLTIQGPAQSKSLTLRTFVGAHvPLYLHLDSLRLRQILVNLLGNAVKFTETGG-IRLRVKRHE-QQLC 546

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1148848711 691 ITIQDEGHGIPEELMPHLGEPF--ITNKETGTGLGLMVSQRIIQGHQGTLEIESKSGVGTKISIVLP 755
Cdd:PRK15347  547 FTVEDTGCGIDIQQQQQIFTPFyqADTHSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLP 613

COG3920

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...

265-761

1.96e-16

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];

Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 83.03 E-value: 1.96e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 265 GKLDQDMEAVRDAVSTGENVVLVDTIQGKKVLKSFIPIDYEDKPTNVIGVVMDYEAISSVMREQMISLVAISLVLLEIVI 344
Cdd:COG3920    14 AALLLLAALLLLAAALLLALLALLLLALLLLALLLASALLALLALSAAALAAALAVALAAAVGAAAALLALLVLLLLLLL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 345 FGSYIVAGYFTKPIQSILRTVNDVADGHFDRRLEVTSRDELGQLAGRINAMTRNLGHYTSQLKQMVEENQSVKEYLESII 424
Cdd:COG3920    94 AAAALALALLLAALAGLLLLAALLLLRLVALLAALALLALLLLLLLLLAILALAELAVALAELAAALLLLAEELAALRLA 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 425 NQTADAIHTTDTHERVISVNNAFEQLYGWKANEVIGQKLELVPPSKLDEERDRLRRLREGERLPPVETVRMRKDGSLIEV 504
Cdd:COG3920   174 AAALLLLLAALLDLGLALAALAAAALLALLLALELLLALLLLLLLLLALLLVLLAALLRLRAAVLEELERRRRARGLGRL 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 505 SISTSLVRDEQGQVTSMISVSRD-VTERNRIEELLRRSEKLNTVgqLAAGVAHEIRNPLTTLRGFLQLQqqTQSVNADHI 583
Cdd:COG3920   254 LLLLLLLLLLLRALLLLAAGIRLvITERKRAEEELEASLEEKEL--LLRELHHRVKNNLQVVSSLLRLQ--ARRADDPEA 329

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 584 DLMLSEL-DRINLI--VSEFLIlakpQAIHFQERDVRGILRDVISFLDSQAHLYGVEVKLD-----FSPEPA-----LVH 650
Cdd:COG3920   330 REALEESqNRIQALalVHELLY----QSEDWEGVDLRDYLRELLEPLRDSYGGRGIRIELDgpdveLPADAAvplglILN 405

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 651 ceEnqlkqVFINLLKNAFEAMPDGgTVTITLKRpGGDHVLITIQDEGHGIPEELmphlgepfitNKETGTGLGLMVSQRI 730
Cdd:COG3920   406 --E-----LVTNALKHAFLSGEGG-RIRVSWRR-EDGRLRLTVSDNGVGLPEDV----------DPPARKGLGLRLIRAL 466

                         490       500       510
                  ....*....|....*....|....*....|.
gi 1148848711 731 IQGHQGTLEIESKSgvGTKISIVLPAARRQS 761
Cdd:COG3920   467 VRQLGGTLELDRPE--GTRVRITFPLAELAA 495

HATPase_TutC-TodS-like

cd16925

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...

655-755

6.04e-16

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.

Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 74.45 E-value: 6.04e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 655 QLKQVFINLLKNAFEAMPDGGTVTITLKRPGGDHVLITIQDEGHGIPEELMPHLGEPF------ITNKETGTGLGLMVSQ 728
Cdd:cd16925     4 KYERVVLNLLSNAFKFTPDGGRIRCILEKFRLNRFLLTVSDSGPGIPPNLREEIFERFrqgdgsSTRAHGGTGLGLSIVK 83

                          90       100
                  ....*....|....*....|....*..
gi 1148848711 729 RIIQGHQGTLEIESKSGVGTKISIVLP 755
Cdd:cd16925    84 EFVELHGGTVTVSDAPGGGALFQVELP 110

PRK10490

sensor protein KdpD; Provisional

514-755

7.40e-16

sensor protein KdpD; Provisional

Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 82.01 E-value: 7.40e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 514 EQGQVTSMISVSRDVTERnrieELLRRSeklntvgqLAAGVAHEIRNPLTTLRG-----FLQLQQQ----TQSVNA--DH 582
Cdd:PRK10490  643 ERLTLTASEEQARLASER----EQLRNA--------LLAALSHDLRTPLTVLFGqaeilTLDLASEgsphARQASEirQQ 710

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 583 IdlmlseLDRINLiVSEFLILAKPQAIHFQERDVRGILRDVI-SFLDSQAH-LYGVEVKLDFSPEPALVHCEENQLKQVF 660
Cdd:PRK10490  711 V------LNTTRL-VNNLLDMARIQSGGFNLRKEWLTLEEVVgSALQMLEPgLSGHPINLSLPEPLTLIHVDGPLFERVL 783

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 661 INLLKNAFEAMPDGGTVTITlKRPGGDHVLITIQDEGHGIPEELMPHLGEPFI-TNKET---GTGLGLMVSQRIIQGHQG 736
Cdd:PRK10490  784 INLLENAVKYAGAQAEIGID-AHVEGERLQLDVWDNGPGIPPGQEQLIFDKFArGNKESaipGVGLGLAICRAIVEVHGG 862

                         250
                  ....*....|....*....
gi 1148848711 737 TLEIESKSGVGTKISIVLP 755
Cdd:PRK10490  863 TIWAENRPEGGACFRVTLP 881

sensory_box

TIGR00229

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ...

418-538

8.53e-16

Pssm-ID: 272971 [Multi-domain] Cd Length: 124 Bit Score: 74.25 E-value: 8.53e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 418 EYLESIINQTADAIHTTDTHERVISVNNAFEQLYGWKANEVIGQK-LELVPPSKLDEERDRLRRLREGERLPPVETVR-M 495
Cdd:TIGR00229   3 ERYRAIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSAEELIGRNvLELIPEEDREEVRERIERRLEGEPEPVSEERRvR 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1148848711 496 RKDGSLIEVSISTSLVRdEQGQVTSMISVSRDVTERNRIEELL 538
Cdd:TIGR00229  83 RKDGSEIWVEVSVSPIR-TNGGELGVVGIVRDITERKEAEEAL 124

RocR

COG3829

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ...

408-543

1.39e-15

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];

Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 79.82 E-value: 1.39e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 408 QMVEENQSVKEYLESIINQTADAIHTTDTHERVISVNNAFEQLYGWKANEVIGQKL-ELVPPSKLDEERDRLRrlreger 486
Cdd:COG3829     1 AEELELKELEEELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNVtELIPNSPLLEVLKTGK------- 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1148848711 487 lpPVETVRMRKDGSLIEVSISTSLVRdEQGQVTSMISVSRDVTERNRIEELLRRSEK 543
Cdd:COG3829    74 --PVTGVIQKTGGKGKTVIVTAIPIF-EDGEVIGAVETFRDITELKRLERKLREEEL 127

HATPase_EcPhoR-like

cd16952

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

656-758

6.64e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.

Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 71.08 E-value: 6.64e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 656 LKQVFINLLKNAFEAMPDGGTVTITLKR-PGGDHvlITIQDEGHGIPEELMPHLGEPFI------TNKETGTGLGLMVSQ 728
Cdd:cd16952     1 LRSAFSNLVSNAVKYTPPSDTITVRWSQeESGAR--LSVEDTGPGIPPEHIPRLTERFYrvdierCRNTGGTGLGLAIVK 78

                          90       100       110
                  ....*....|....*....|....*....|
gi 1148848711 729 RIIQGHQGTLEIESKSGVGTKISIVLPAAR 758
Cdd:cd16952    79 HVMSRHDARLLIASELGKGSRFTCLFPSSR 108

HATPase_CpxA-like

cd16949

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

656-756

8.76e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.

Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 70.82 E-value: 8.76e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 656 LKQVFINLLKNAFEAMPdgGTVTITLKRPGgDHVLITIQDEGHGIPEELMPHLGEPF-----ITNKET-GTGLGLMVSQR 729
Cdd:cd16949     1 LARALENVLRNALRYSP--SKILLDISQDG-DQWTITITDDGPGVPEDQLEQIFLPFyrvdsARDRESgGTGLGLAIAER 77

                          90       100
                  ....*....|....*....|....*..
gi 1148848711 730 IIQGHQGTLEIESKSGVGTKISIVLPA 756
Cdd:cd16949    78 AIEQHGGKIKASNRKPGGLRVRIWLPA 104

PRK11466

hybrid sensory histidine kinase TorS; Provisional

552-758

1.08e-14

hybrid sensory histidine kinase TorS; Provisional

Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 78.41 E-value: 1.08e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 552 AGVAHEIRNPLTTLRGFLQLQQQTQSVNADHIDLML------SELDRINLIVSEFLILAKPQAIHFQER--DVRGILRDV 623
Cdd:PRK11466  449 AAMSHEIRTPLYGILGTAQLLADNPALNAQRDDLRAitdsgeSLLTILNDILDYSAIEAGGKNVSVSDEpfEPRPLLEST 528

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 624 ISFLDSQAHLYGVEVKLDFSPE-PALVHCEENQLKQVFINLLKNAFEAMPDGgtVTITLKRPGGDHVLITIQDEGHGIPE 702
Cdd:PRK11466  529 LQLMSGRVKGRPIRLATDIADDlPTALMGDPRRIRQVITNLLSNALRFTDEG--SIVLRSRTDGEQWLVEVEDSGCGIDP 606

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1148848711 703 ELMPHLGEPFI--TNKETGTGLGLMVSQRIIQGHQGTLEIESKSGVGTKISIVLPAAR 758
Cdd:PRK11466  607 AKLAEIFQPFVqvSGKRGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPLRV 664

PAS

COG2202

PAS domain [Signal transduction mechanisms];

382-538

2.15e-14

PAS domain [Signal transduction mechanisms];

Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 73.91 E-value: 2.15e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 382 RDELGQLAGRInAMTRNLghytSQLKQMVEENQSVKEYLESIINQTADAIHTTDTHERVISVNNAFEQLYGWKANEVIGQ 461
Cdd:COG2202   106 RDEDGEITGFV-GIARDI----TERKRAEEALRESEERLRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELLGK 180

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1148848711 462 KLELVPPSKLDEERDRLRRLREGERLPPVETVRMRKDGSLIEVSISTSLVRDE-QGQVTSMISVSRDVTERNRIEELL 538
Cdd:COG2202   181 SLLDLLHPEDRERLLELLRRLLEGGRESYELELRLKDGDGRWVWVEASAVPLRdGGEVIGVLGIVRDITERKRAEEAL 258

PRK11091

aerobic respiration control sensor protein ArcB; Provisional

526-769

2.64e-14

aerobic respiration control sensor protein ArcB; Provisional

Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 76.90 E-value: 2.64e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 526 RDVTERNRIEELLRRSEKLNTvgQLAAGVAHEIRNPLTTLRGF--------LQLQQ----QTQSVNA--------DHIDL 585
Cdd:PRK11091  264 RDITERKRYQDALEKASRDKT--TFISTISHELRTPLNGIVGLsrilldteLTAEQrkylKTIHVSAitlgnifnDIIDM 341

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 586 MLSELDRINLivseflilaKPQAIhfqerDVRGILRDVISFLDSQAHLYGVevKLDFSPE---PALVHCEENQLKQVFIN 662
Cdd:PRK11091  342 DKMERRKLQL---------DNQPI-----DFTDFLADLENLSGLQAEQKGL--RFDLEPLlplPHKVITDGTRLRQILWN 405

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 663 LLKNAFEAMPDGGtVTITLKRPGGDHVLITIQDEGHGIPEElmpHLGEPFI----------TNKETGTGLGLMVSQRIIQ 732
Cdd:PRK11091  406 LISNAVKFTQQGG-VTVRVRYEEGDMLTFEVEDSGIGIPED---ELDKIFAmyyqvkdshgGKPATGTGIGLAVSKRLAQ 481

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1148848711 733 GHQGTLEIESKSGVGT--KISIVLPAARRQSDMEATSND 769
Cdd:PRK11091  482 AMGGDITVTSEEGKGScfTLTIHAPAVAEEVEDAFDEDD 520

HATPase_CreC-like

cd16945

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

656-745

2.81e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.

Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 69.41 E-value: 2.81e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 656 LKQVFINLLKNAFEAMPDGGTVTITLkRPGGDHVLITIQDEGHGIPEELMPHLGEPFIT-----NKETGTGLGLMVSQRI 730
Cdd:cd16945     5 LRQAINNLLDNAIDFSPEGGLIALQL-EADTEGIELLVFDEGSGIPDYALNRVFERFYSlprphSGQKSTGLGLAFVQEV 83

                          90
                  ....*....|....*
gi 1148848711 731 IQGHQGTLEIESKSG 745
Cdd:cd16945    84 AQLHGGRITLRNRPD 98

PRK10549

two-component system sensor histidine kinase BaeS;

512-755

5.77e-14

two-component system sensor histidine kinase BaeS;

Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 75.05 E-value: 5.77e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 512 RDEQGQVTSMISVSRDVTERNrieELLRRSeklntvgqLAAGVAHEIRNPLTTLRGFLQ-LQQQTQSVNADHIDLMLSEL 590
Cdd:PRK10549  216 RDELGRLAQDFNQLASTLEKN---EQMRRD--------FMADISHELRTPLAVLRGELEaIQDGVRKFTPESVASLQAEV 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 591 DRINLIVSEF--LILAKPQAIHFQER--DVRGILRDVI-SFLDSQAHlYGVEVKLDFsPEPALVHCEENQLKQVFINLLK 665
Cdd:PRK10549  285 GTLTKLVDDLhqLSLSDEGALAYRKTpvDLVPLLEVAGgAFRERFAS-RGLTLQLSL-PDSATVFGDPDRLMQLFNNLLE 362

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 666 NAFEAMPDGGTVTITLKRPGgDHVLITIQDEGHGIPEELMPHLGEPFIT-----NKETG-TGLGLMVSQRIIQGHQGTLE 739
Cdd:PRK10549  363 NSLRYTDSGGSLHISAEQRD-KTLRLTFADSAPGVSDEQLQKLFERFYRtegsrNRASGgSGLGLAICLNIVEAHNGRII 441

                         250
                  ....*....|....*.
gi 1148848711 740 IESKSGVGTKISIVLP 755
Cdd:PRK10549  442 AAHSPFGGVSITVELP 457

HATPase_EnvZ-like

cd16950

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

656-755

4.04e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.

Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 65.93 E-value: 4.04e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 656 LKQVFINLLKNAFEAmpDGGTVTItlkRPGGDHVLITIQ--DEGHGIPEELMPHLGEPFITNKET----GTGLGLMVSQR 729
Cdd:cd16950     1 LKRVLSNLVDNALRY--GGGWVEV---SSDGEGNRTRIQvlDNGPGIAPEEVDELFQPFYRGDNArgtsGTGLGLAIVQR 75

                          90       100
                  ....*....|....*....|....*.
gi 1148848711 730 IIQGHQGTLEIESKSGVGTKISIVLP 755
Cdd:cd16950    76 ISDAHGGSLTLANRAGGGLCARIELP 101

nifL_nitrog

TIGR02938

nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation ...

522-755

4.14e-13

nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions]

Pssm-ID: 131984 [Multi-domain] Cd Length: 494 Bit Score: 72.24 E-value: 4.14e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 522 ISVSRDVTERNR---IEELLRRSEKLNTVGQLAAGVAHEIRNPLTTLRGFLQ-LQQQTQSVNADHIDLMLSEL---DRIN 594
Cdd:TIGR02938 248 ISNLREEQERARlsaLQALMAEEERLEAIRETLSAAIHRLQGPMNLISAAISvLQRRGDDAGNPASAAMLQQAlsaGREH 327

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 595 LIVSEFLILAKPQAIhFQERDVRGILRDVISFLDSQAHLYGVEVklDFSPEPAL--VHCEENQLKQVFINLLKNAFEAMP 672
Cdd:TIGR02938 328 MEALRQVIPQSPQEI-VVPVNLNQILRDVITLSTPRLLAAGIVV--DWQPAATLpaILGRELQLRSLFKALVDNAIEAMN 404

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 673 DGGTVTITLK---RPGGDHVLITIQDEGHGIPEELMPHLGEPFITNK---ETGTGLGLMVSQRIIQGHQGTLEIESKSGV 746
Cdd:TIGR02938 405 IKGWKRRELSittALNGDLIVVSILDSGPGIPQDLRYKVFEPFFTTKggsRKHIGMGLSVAQEIVADHGGIIDLDDDYSE 484


                  ....*....
gi 1148848711 747 GTKISIVLP 755
Cdd:TIGR02938 485 GCRIIVEFR 493

HATPase_BaeS-like

cd16946

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

652-755

4.77e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.

Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 65.95 E-value: 4.77e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 652 EENQLKQVFINLLKNAFEAMPDGGTVTI-TLKRPggDHVLITIQDEGHGIPEELMPHLGEPFI------TNKETGTGLGL 724
Cdd:cd16946     1 DRDRLQQLFVNLLENSLRYTDTGGKLRIrAAQTP--QEVRLDVEDSAPGVSDDQLARLFERFYrvessrNRASGGSGLGL 78

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1148848711 725 MVSQRIIQGHQGTLEIESKSGVGTKISIVLP 755
Cdd:cd16946    79 AICHNIALAHGGTISAEHSPLGGLRLVLTLP 109

HAMP

cd06225

Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ...

355-399

7.92e-13

Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 63.23 E-value: 7.92e-13

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1148848711 355 TKPIQSILRTVNDVADGHFDRRLEVTSRDELGQLAGRINAMTRNL 399
Cdd:cd06225     1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45

Tar

COG0840

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];

265-450

1.19e-12

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];

Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 71.20 E-value: 1.19e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 265 GKLDQDMEAVRDAVSTGENVVLVDTIQGKKVLKSFIPIDYEDKPTNVIGVVMDYEAISSVMREQMISLVAISLVLLEIVI 344
Cdd:COG0840   117 ELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALLEAAALALAAAALALALLAAALLALVALAI 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 345 FGSYIVAGYFTKPIQSILRTVNDVADGHFDRRLEVTSRDELGQLAGRINAMTRNLGHYTSQLKQMVEENQSVKEYLESII 424
Cdd:COG0840   197 ILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENLRELVGQVRESAEQVASASEELAASA 276

                         170       180
                  ....*....|....*....|....*.
gi 1148848711 425 NQTADAihTTDTHERVISVNNAFEQL 450
Cdd:COG0840   277 EELAAG--AEEQAASLEETAAAMEEL 300

PRK10337

sensor protein QseC; Provisional

555-735

1.20e-12

sensor protein QseC; Provisional

Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 70.83 E-value: 1.20e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 555 AHEIRNPLTTLRgflqlqQQTQSVNADHIDLMLSE---------LDRINLIVSEFLILAKPQAIH----FQERDVRGILR 621
Cdd:PRK10337  245 AHELRSPLAALK------VQTEVAQLSDDDPQARKkallqlhagIDRATRLVDQLLTLSRLDSLDnlqdVAEIPLEDLLQ 318

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 622 DVISFLDSQAHLYGVEVKLDFSPEPALVHCEENQLKQVFINLLKNAFEAMPDGGTVTITLkrpggDHVLITIQDEGHGIP 701
Cdd:PRK10337  319 SAVMDIYHTAQQAGIDVRLTLNAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTL-----NARNFTVRDNGPGVT 393

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1148848711 702 EELMPHLGEPFIT---NKETGTGLGLMVSQRIIQGHQ 735
Cdd:PRK10337  394 PEALARIGERFYRppgQEATGSGLGLSIVRRIAKLHG 430

HATPase_BasS-like

cd16940

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

645-752

1.25e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.

Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 64.73 E-value: 1.25e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 645 EPALVHCEENQLKQVFINLLKNAFEAMPDGGTVTITLKrpGGDHVLITIQDEGHGIPEELMPHLGEPFI---TNKETGTG 721
Cdd:cd16940     3 ADIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLS--ADDGAVIRVEDNGPGIDEEELEALFERFYrsdGQNYGGSG 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1148848711 722 LGLMVSQRIIQGHQGTLEIESKSGVGTKISI 752
Cdd:cd16940    81 LGLSIVKRIVELHGGQIFLGNAQGGGLEAWV 111

HATPase_LytS-like

cd16957

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

658-755

1.63e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.

Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 64.37 E-value: 1.63e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 658 QVFI-NLLKNAFEAMPDGGTVTITLKRPGGdHVLITIQDEGHGIPEELMPHLGEPFITNKEtGTGLGLM-VSQRIIQ--G 733
Cdd:cd16957     7 QVLVeNAIRHAFPKRKENNEVRVVVKKDQH-KVHVSVSDNGQGIPEERLDLLGKTTVTSEK-GTGTALEnLNRRLIGlfG 84

                          90       100
                  ....*....|....*....|..
gi 1148848711 734 HQGTLEIESKSGVGTKISIVLP 755
Cdd:cd16957    85 SEACLHIESEVHGGTEVWFVIP 106

YesM

COG2972

Sensor histidine kinase YesM [Signal transduction mechanisms];

175-759

1.03e-11

Sensor histidine kinase YesM [Signal transduction mechanisms];

Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 67.74 E-value: 1.03e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 175 DMIYKWGYYYDGKRNYIIDPYIQNSTFKDYVKVTSPDTVVQETLKANPHILEVTGINPDTFGNQYMREDGSDDVHYKLYN 254
Cdd:COG2972     2 SKSLSLLSIVLLLLILLLLVLLILLLSLLLIILLLLLLLILLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 255 RPITFGTYHYGKLDQDMEAVRDAVSTGENVVLVDTIQGKKVLKSFIPIDYEDKPTNVIGVVMDYEAISSVMREQMISLVA 334
Cdd:COG2972    82 ILLLLLLLLLLLILLLSLLLLLALILLLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLRRLILL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 335 ISLVLLEIVIFGSYIVAGYFTKPIQSILRTVNDVADGHFdRRLEVTSRDELGQLAGRINAMTRNLGHYTSQLKQMV-EEN 413
Cdd:COG2972   162 IILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDL-VRLEVSGNDEIGILARSFNEMVERIKELIEEVYELElEKK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 414 QSVKEYLESIINQtadaihttdtHervisvnnaFeqLYgwkaN--EVIGQKLELvppskldeerdrlrrlregerLPPVE 491
Cdd:COG2972   241 EAELKALQAQINP----------H---------F--LF----NtlNSIRWLAEL---------------------EDPEE 274

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 492 TVRMrkdgslievsistslvrdeqgqVTSMISVSRDVternrieelLRRSEKLNTVGQlaagvahEIRNplttLRGFLQL 571
Cdd:COG2972   275 AEEM----------------------LEALSKLLRYS---------LSKGDELVTLEE-------ELEL----IKSYLEI 312

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 572 QQqtqsvnadhidlmlseldrinlivseflilakpqaIHFQERdvrgilrdvisfldsqahlygVEVKLDFSPEPALVHC 651
Cdd:COG2972   313 QK-----------------------------------LRFGDR---------------------LEVEIEIDEELLDLLI 336

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 652 eenqLKQVFINLLKNAF----EAMPDGGTVTITLKRpGGDHVLITIQDEGHGIPEELMPHLGEPFiTNKETGTGLGLM-V 726
Cdd:COG2972   337 ----PKLILQPLVENAIehgiEPKEGGGTIRISIRK-EGDRLVITVEDNGVGMPEEKLEKLLEEL-SSKGEGRGIGLRnV 410

                         570       580       590
                  ....*....|....*....|....*....|....*
gi 1148848711 727 SQRI--IQGHQGTLEIESKSGVGTKISIVLPAARR 759
Cdd:COG2972   411 RERLklYYGEEYGLEIESEPGEGTTVTIRIPLEEE 445

HAMP

COG2770

HAMP domain [Signal transduction mechanisms];

211-631

1.05e-11

HAMP domain [Signal transduction mechanisms];

Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 68.22 E-value: 1.05e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 211 DTVVQETLKANPHILEVTGINPDTFGNQYMREDGSDDVHYKLYNRPITFGTYHYGKLDQDMEAVRDAVSTGENVVLVDTI 290
Cdd:COG2770    93 ALLLLLLLALLLLLAALLLLLLLAALALLLLLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAALALALGAGE 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 291 QGKKVLKSFIPIDYEDKPTNVIGVVMDYEAISSVMREQMISLVAISLVLLEIVIFGSYIVAGYFTKPIQSILRTVNDVAD 370
Cdd:COG2770   173 LLLLADLAAAIAALLAALLLLLLGGLLLVVLLEAALAALLLLLLLALLALLLALLLALLLARRITRPLRRLAEAARRIAA 252

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 371 GHFDRRLEVTSRDELGQLAGRINAMTRNLGHYTSQLKQMVEENQSVKEYLES---IINQTADAIHTTDTHERVISVNNAF 447
Cdd:COG2770   253 GDLDVRIPVSRKDEIGELARAFNRMADSLRESIEEAEEEEELAEAELARLLEallELLLALLLLLLALLLLAAAALLLEL 332

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 448 EQLYGWKANEVIGQKLELVPPSKLDEERDRLRRLREGERLPPVETVRMRKDGSLIEVSISTSLVRDEQGQVTSMISVSRD 527
Cdd:COG2770   333 LLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEEL 412

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 528 VTERNRIEELLRRSEKLNTVGQLAAGVAHEIRNPLTTLRGFLQLQQQTQSVNADHIDLMLSELDRINLIVSEFLILAKPQ 607
Cdd:COG2770   413 VLALLALALLALAAAAAAAEAAAAALELAAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGALELLLL 492

                         410       420
                  ....*....|....*....|....
gi 1148848711 608 AIHFQERDVRGILRDVISFLDSQA 631
Cdd:COG2770   493 EEEEEAGAAAEELAEELLLLEGLL 516

HisKA

pfam00512

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...

548-608

1.55e-11

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.

Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 60.30 E-value: 1.55e-11

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1148848711 548 GQLAAGVAHEIRNPLTTLRGFLQL--QQQTQSVNADHIDLMLSELDRINLIVSEFLILAKPQA 608
Cdd:pfam00512   3 SEFLANLSHELRTPLTAIRGYLELlrDEKLDEEQREYLETILRSAERLLRLINDLLDLSRIEA 65

HATPase_BvrS-ChvG-like

cd16953

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

656-755

2.24e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.

Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 61.43 E-value: 2.24e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 656 LKQVFINLLKNAFEAMPDGgTVTITLKR-PGGDHVLITIQDEGHGIPEELMPHLGEPFITNKETG------TGLGLMVSQ 728
Cdd:cd16953     1 LGQVLRNLIGNAISFSPPD-TGRITVSAmPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANeafgqhSGLGLSISR 79

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1148848711 729 RIIQGHQGTLEIESKS----GVGTKISIVLP 755
Cdd:cd16953    80 QIIEAHGGISVAENHNqpgqVIGARFTVQLP 110

HisKA

cd00082

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...

544-605

4.64e-11

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.

Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 58.76 E-value: 4.64e-11

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1148848711 544 LNTVGQLAAGVAHEIRNPLTTLRGFLQLQQQTQSVNADH---IDLMLSELDRINLIVSEFLILAK 605
Cdd:cd00082     1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQreyLERIREEAERLLRLINDLLDLSR 65

HisKA

smart00388

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...

548-608

8.09e-11

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.

Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 58.35 E-value: 8.09e-11

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1148848711  548 GQLAAGVAHEIRNPLTTLRGFLQL--QQQTQSVNADHIDLMLSELDRINLIVSEFLILAKPQA 608
Cdd:smart00388   3 REFLANLSHELRTPLTAIRGYLELllDTELSEEQREYLETILREAERLLRLINDLLDLSRIEA 65

NarQ

COG3850

Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ...

328-628

8.93e-11

Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];

Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 64.90 E-value: 8.93e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 328 QMISLVAISLVLLeIVIFGSYIVAGYFTKPIQSILRTVNDVADGHFDRRLEVTSRDELGQLAGRINAMTRNLGHYTSQLK 407
Cdd:COG3850   117 RKLALLRLLLALL-LALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGRDELGTLARAFNRMADELQELYAELE 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 408 QmvEENQSVKEYLESIINQTADAIHTTDTHERVISVNNAfeqlygwkANEVIGQKLELVPPSKLDEERDRLRRLREGERL 487
Cdd:COG3850   196 E--EEELEAELELLALLDELLLLAALLLLLALLLALLLA--------ALLAALLLLLLLQDALAESELLALNILAGLLEL 265

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 488 PPVETVRMRKDGSLIEVSISTSLVRDEQGQVTSMISVSRDVTERNRIEELLRRSEKLNTVGQLAAGVAHEIRNPLTTLRG 567
Cdd:COG3850   266 LLALLLLLLASALLLLELELLALLLELVELLALAAAEEALLLLVELAALLLLLLLQAIANASLLLIALASVVAALLELAS 345

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1148848711 568 FLQLQQQTQSVNADHIDLMLSELDRINLIVSEFLILAKPQAIHFQERDVRGILRDVISFLD 628
Cdd:COG3850   346 ILALQAALEAAAAGAALAAAAAAAGLARALAQAGADAAEALGLLAEASEGAAGQGAGLVDV 406

HATPase_DpiB-CitA-like

cd16915

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

662-755

1.00e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.

Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 59.22 E-value: 1.00e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 662 NLLKNAFEA---MPDG-GTVTITLkRPGGDHVLITIQDEGHGIPEELMPHLGEPFITNKETGT-GLGLMVSQRIIQGHQG 736
Cdd:cd16915     7 NLIDNALDAlaaTGAPnKQVEVFL-RDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQGErGIGLALVRQSVERLGG 85

                          90
                  ....*....|....*....
gi 1148848711 737 TLEIESKSGVGTKISIVLP 755
Cdd:cd16915    86 SITVESEPGGGTTFSIRIP 104

HAMP

pfam00672

HAMP domain;

349-399

1.09e-10

HAMP domain;

Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 57.25 E-value: 1.09e-10

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1148848711 349 IVAGYFTKPIQSILRTVNDVADGHFDRRLEVTSRDELGQLAGRINAMTRNL 399
Cdd:pfam00672   1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERL 51

HATPase_SpaK_NisK-like

cd16975

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

652-752

1.45e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.

Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 59.01 E-value: 1.45e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 652 EENQLKQVFINLLKNAFEAMPDGGTVTITLKrpgGDHVLIT--IQDEGHGIPEELMPHLGEPFITNKETGT-----GLGL 724
Cdd:cd16975     1 DTLLLSRALINIISNACQYAPEGGTVSISIY---DEEEYLYfeIWDNGHGFSEQDLKKALELFYRDDTSRRsgghyGMGL 77

                          90       100
                  ....*....|....*....|....*...
gi 1148848711 725 MVSQRIIQGHQGTLEIESKSGVGTKISI 752
Cdd:cd16975    78 YIAKNLVEKHGGSLIIENSQKGGAEVTV 105

PAS_9

pfam13426

PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ...

437-530

1.59e-10

PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).

Pssm-ID: 463873 [Multi-domain] Cd Length: 93 Bit Score: 58.24 E-value: 1.59e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 437 HERVISVNNAFEQLYGWKANEVIGQKL-ELVPPSKLDEERDRLRRLREGERlpPVETVRMRKDGSLIEVSISTSLVRDEQ 515
Cdd:pfam13426   1 DGRIIYVNDAALRLLGYTREELLGKSItDLFAEPEDSERLREALREGKAVR--EFEVVLYRKDGEPFPVLVSLAPIRDDG 78

                          90
                  ....*....|....*
gi 1148848711 516 GQVTSMISVSRDVTE 530
Cdd:pfam13426  79 GELVGIIAILRDITE 93

HATPase_YpdA-YehU-LytS-like

cd16924

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

662-755

2.51e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.

Pssm-ID: 340401 [Multi-domain] Cd Length: 103 Bit Score: 57.84 E-value: 2.51e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 662 NLLKNAFEAMPDGGTVTITLKRPGGdHVLITIQDEGHGIPEELMPHLGEpfitNKETGTGLGLM-VSQRIIQ--GHQGTL 738
Cdd:cd16924    12 NAIQHGLSPLTDKGVVTISALKEDN-HVMIEVEDNGRGIDPKVLNILGK----KPKEGNGIGLYnVHQRLILlfGEDYGI 86

                          90
                  ....*....|....*..
gi 1148848711 739 EIESKSGVGTKISIVLP 755
Cdd:cd16924    87 HIASEPDKGTRITFTIP 103

HATPase_FilI-like

cd16921

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

656-755

3.59e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.

Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 57.72 E-value: 3.59e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 656 LKQVFINLLKNAFEAMPDGGTVTITL-KRPGGDHVLITIQDEGHGIPEELMPHLGEPF--ITNKET--GTGLGLMVSQRI 730
Cdd:cd16921     1 LGQVLTNLLGNAIKFRRPRRPPRIEVgAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFqrLHSREEyeGTGVGLAIVRKI 80

                          90       100
                  ....*....|....*....|....*
gi 1148848711 731 IQGHQGTLEIESKSGVGTKISIVLP 755
Cdd:cd16921    81 IERHGGRIWLESEPGEGTTFYFTLP 105

HAMP

smart00304

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;

353-399

4.52e-10

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;

Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 55.72 E-value: 4.52e-10

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1148848711  353 YFTKPIQSILRTVNDVADGHFDRRLEVTSRDELGQLAGRINAMTRNL 399
Cdd:smart00304   2 RLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRL 48

PRK11086

sensory histidine kinase DcuS; Provisional

608-763

5.22e-10

sensory histidine kinase DcuS; Provisional

Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 62.62 E-value: 5.22e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 608 AIHFQErDVRGILRDVIS-----FL---DSQAHLYGVEvkLDFSPEPALVHCEENQLKQVFI----NLLKNAFEAMP--D 673
Cdd:PRK11086  377 ANNYQE-EIGSLLGKIKSpviagFLlgkISRARELGIT--LIISEDSQLPDSGDEDQVHELItilgNLIENALEAVGgeE 453

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 674 GGTVTITLkRPGGDHVLITIQDEGHGIPEELMPHLGEPFITNKETGTGLGLMVSQRIIQGHQGTLEIESKSGVGTKISIV 753
Cdd:PRK11086  454 GGEISVSL-HYRNGWLHCEVSDDGPGIAPDEIDAIFDKGYSTKGSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQ 532

                         170
                  ....*....|
gi 1148848711 754 LPAARRQSDM 763
Cdd:PRK11086  533 IPWDGERSNR 542

cpxA

PRK09470

envelope stress sensor histidine kinase CpxA;

554-755

9.99e-10

envelope stress sensor histidine kinase CpxA;

Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 61.49 E-value: 9.99e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 554 VAHEIRNPLTTLR--GFLQLQQQTQSVNADHIDlmlSELDRINLIVSEFLILAKPQAIHFQERDV-------RGILRDVi 624
Cdd:PRK09470  250 ISHELRTPLTRLQlaTALLRRRQGESKELERIE---TEAQRLDSMINDLLVLSRNQQKNHLERETfkanslwSEVLEDA- 325

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 625 SFLDSQAHLygvevKLDFS--PEPALVHCEENQLKQVFINLLKNAFEAMPDGGTVTITLKRPGgdhVLITIQDEGHGIPE 702
Cdd:PRK09470  326 KFEAEQMGK-----SLTVSapPGPWPINGNPNALASALENIVRNALRYSHTKIEVAFSVDKDG---LTITVDDDGPGVPE 397

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 703 ELMPHLGEPFITNKET------GTGLGLMVSQRIIQGHQGTLEIEsKSGV-GTKISIVLP 755
Cdd:PRK09470  398 EEREQIFRPFYRVDEArdresgGTGLGLAIVENAIQQHRGWVKAE-DSPLgGLRLTIWLP 456

PRK13558

bacterio-opsin activator; Provisional

379-547

2.87e-09

bacterio-opsin activator; Provisional

Pssm-ID: 237426 [Multi-domain] Cd Length: 665 Bit Score: 60.62 E-value: 2.87e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 379 VTSRDELGQLAGRIN----AMTRNLGHYTSQLKQMVEENQSVKEYL--ESIINQT-ADAihtTDTHERVISVNNAFEQLY 451
Cdd:PRK13558  108 AVSDDATAAIAERIEsavpEHSRDTEARMPISDLTVESDRRLKERAldEAPVGITiADA---TLPDEPLIYINDAFERIT 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 452 GWKANEVIGQKLELVPPSKLDEERDRLRRLREGERLP-PVETVRMRKDGSLIEVSISTSLVRDEQGQVTSMISVSRDVTE 530
Cdd:PRK13558  185 GYSPDEVLGRNCRFLQGEDTNEERVAELREAIDEERPtSVELRNYRKDGSTFWNQVDIAPIRDEDGTVTHYVGFQTDVTE 264

                         170
                  ....*....|....*...
gi 1148848711 531 RNRIE-ELLRRSEKLNTV 547
Cdd:PRK13558  265 RKEAElALQRERRKLQRL 282

PRK13560

hypothetical protein; Provisional

497-755

2.88e-09

hypothetical protein; Provisional

Pssm-ID: 106506 [Multi-domain] Cd Length: 807 Bit Score: 60.46 E-value: 2.88e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 497 KDGSLIEVSISTSLVRDEQGQVTSMISVSRDVTERNRIEELLRRSEKLNTVgqLAAGVAHEIRNPLTTLRGFLQLQqqTQ 576
Cdd:PRK13560  557 KGGAVCWIDDQSAAERDEEGQISHFEGIVIDISERKHAEEKIKAALTEKEV--LLKEIHHRVKNNLQIISSLLDLQ--AE 632

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 577 SVNADHIDLMLSE-LDRINLIVsefliLAKPQAihFQERDVRGIlrDVISFLDS-QAHLYGV----EVKLDFSPEPALVH 650
Cdd:PRK13560  633 KLHDEEAKCAFAEsQDRICAMA-----LAHEKL--YQSEDLADI--DFLDYIESlTAHLKNSfaidFGRIDCKIDADDGC 703

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 651 CEENQ-------LKQVFINLLKNAFeamPDG--GTVTITLKRPGGDHVLITIQDEGHGIPEELMphlgepfITNKETgtg 721
Cdd:PRK13560  704 LDIDKaipcgliISELLSNALKHAF---PDGaaGNIKVEIREQGDGMVNLCVADDGIGLPAGFD-------FRAAET--- 770

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1148848711 722 LGLMVSQRIIQGHQGTLEIESKSgvGTKISIVLP 755
Cdd:PRK13560  771 LGLQLVCALVKQLDGEIALDSRG--GARFNIRFP 802

HATPase_RstB-like

cd16939

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

656-756

2.96e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.

Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 55.13 E-value: 2.96e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 656 LKQVFINLLKNAFEAMPDggTVTITLkRPGGDHVLITIQDEGHGIPEELMPHLGEPFI------TNKETGTGLGLMVSQR 729
Cdd:cd16939     1 MARALDNLLRNALRYAHR--TVRIAL-LVSGGRLTLIVEDDGPGIPAAARERVFEPFVrldpsrDRATGGFGLGLAIVHR 77

                          90       100
                  ....*....|....*....|....*..
gi 1148848711 730 IIQGHQGTLEIESKSGVGTKISIVLPA 756
Cdd:cd16939    78 VALWHGGHVECDDSELGGACFRLTWPR 104

HATPase_PhoQ-like

cd16954

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

635-754

3.67e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.

Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 55.72 E-value: 3.67e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 635 GVEVKLDFSPEpALVHCEENQLKQVFINLLKNAFEAMpdGGTVTITLkRPGGDHVLITIQDEGHGIPEELMPHLGEPFIT 714
Cdd:cd16954    18 GVSISLDISPE-LRFPGERNDLMELLGNLLDNACKWC--LEFVEVTA-RQTDGGLHLIVDDDGPGVPESQRSKIFQRGQR 93

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1148848711 715 NKET--GTGLGLMVSQRIIQGHQGTLEIE-SKSGvGTKISIVL 754
Cdd:cd16954    94 LDEQrpGQGLGLAIAKEIVEQYGGELSLSdSPLG-GARFEVVF 135

HATPase_YcbM-like

cd16947

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

637-754

4.54e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).

Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 55.21 E-value: 4.54e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 637 EVKLDFSPEPALVHCEENQLKQVFINLLKNAFEAMPDGGTVTITLkRPGGDHVLITIQDEGHGIPEELMPHLGEPFITNK 716
Cdd:cd16947     2 QVEINIPDRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTL-REDEKHVYIDIWDKGKGISETEKDHVFERLYTLE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1148848711 717 ET------GTGLGLMVSQRIIQGHQGTLEIESKSGVGTKISIVL 754
Cdd:cd16947    81 DSrnsakqGNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTVTL 124

PRK10841

two-component system sensor histidine kinase RcsC;

656-755

6.78e-09

two-component system sensor histidine kinase RcsC;

Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 59.60 E-value: 6.78e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 656 LKQVFINLLKNAFEaMPDGGTVTITLKRpGGDHVLITIQDEGHGIPEELMPHLGEPFI---TNKET---GTGLGLMVSQR 729
Cdd:PRK10841  563 LQQVISNLLSNAIK-FTDTGCIVLHVRV-DGDYLSFRVRDTGVGIPAKEVVRLFDPFFqvgTGVQRnfqGTGLGLAICEK 640

                          90       100
                  ....*....|....*....|....*.
gi 1148848711 730 IIQGHQGTLEIESKSGVGTKISIVLP 755
Cdd:PRK10841  641 LINMMDGDISVDSEPGMGSQFTIRIP 666

HATPase_BceS-YxdK-YvcQ-like

cd16948

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

656-755

7.41e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.

Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 53.83 E-value: 7.41e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 656 LKQVFINLLKNAFEAMPDGGTVTITLKRpGGDHVLITIQDEGHGIPEELMPHLGEPFIT-----NKETGTGLGLMVSQRI 730
Cdd:cd16948     6 LSFIIGQIVSNALKYSKQGGKIEIYSET-NEQGVVLSIKDFGIGIPEEDLPRVFDKGFTgengrNFQESTGMGLYLVKKL 84

                          90       100
                  ....*....|....*....|....*..
gi 1148848711 731 IQ--GHQgtLEIESKSGVGTKISIVLP 755
Cdd:cd16948    85 CDklGHK--IDVESEVGEGTTFTITFP 109

PAS

pfam00989

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...

418-528

8.38e-09

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).

Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 53.96 E-value: 8.38e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 418 EYLESIINQTADAIHTTDTHERVISVNNAFEQLYGWKANEVIGQKL-ELVPPSKLDEERDRLRRLREGERLP-PVETVRM 495
Cdd:pfam00989   1 EDLRAILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLlDLIPEEDDAEVAELLRQALLQGEESrGFEVSFR 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1148848711 496 RKDGSLIEVSISTSLVRDEQGQVTSMISVSRDV 528
Cdd:pfam00989  81 VPDGRPRHVEVRASPVRDAGGEILGFLGVLRDI 113

HATPase_YehU-like

cd16956

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

662-755

1.03e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.

Pssm-ID: 340432 [Multi-domain] Cd Length: 101 Bit Score: 53.21 E-value: 1.03e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 662 NLLKNAFEAMPDGGTVTITLKRPGGdHVLITIQDEGHGI-PEELMPHLGEPfitnketGTGLGL-MVSQRIIQ--GHQGT 737
Cdd:cd16956    12 NAVKHGLSGLLDGGRVEITARLDGQ-HLLLEVEDNGGGMdPDTLARILIRS-------SNGLGLnLVDKRLRQafGNDYG 83

                          90
                  ....*....|....*...
gi 1148848711 738 LEIESKSGVGTKISIVLP 755
Cdd:cd16956    84 LDIECAPGEGTRITIRLP 101

PAS

cd00130

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...

427-528

2.92e-08

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.

Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 52.25 E-value: 2.92e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 427 TADAIHTTDTHERVISVNNAFEQLYGWKANEVIGQKL-ELVPPSKLDEERDRLRRLREGERLPPVETVRMRKDGSLIEVS 505
Cdd:cd00130     1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLlDLIHPEDREELRERLENLLSGGEPVTLEVRLRRKDGSVIWVL 80

                          90       100
                  ....*....|....*....|...
gi 1148848711 506 ISTSLVRDEQGQVTSMISVSRDV 528
Cdd:cd00130    81 VSLTPIRDEGGEVIGLLGVVRDI 103

PRK10815

two-component system sensor histidine kinase PhoQ;

555-760

5.88e-08

two-component system sensor histidine kinase PhoQ;

Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 55.79 E-value: 5.88e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 555 AHEIRNPL----TTLRGfLQLQQQTQSVNADHIdlMLSELDRINLIVSEFLILAKPQAIH-FQERD---VRGILRDVISF 626
Cdd:PRK10815  274 THSLKTPLavlqSTLRS-LRSGKQMSVEQAEPI--MLEQISRISQQIGYYLHRASMRSEHnLLSRElhsVAPLLDNLTSA 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 627 LDSQAHLYGVEVKLDFSPEPALVHcEENQLKQVFINLLKNA------FeampdggtVTITLkRPGGDHVLITIQDEGHGI 700
Cdd:PRK10815  351 LNKVYQRKGVNITLDISPEITFVG-EKNDFMEVMGNVLDNAckycleF--------VEISA-RQTDEHLHIVVEDDGPGI 420

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1148848711 701 PE---ELMPHLGEPFITNKeTGTGLGLMVSQRIIQGHQGTLEIESKSGVGTKISIVLpaaRRQ 760
Cdd:PRK10815  421 PEskrELIFDRGQRADTLR-PGQGLGLSVAREITEQYEGKISAGDSPLGGARMEVIF---GRQ 479

PRK11107

hybrid sensory histidine kinase BarA; Provisional

552-748

1.15e-07

hybrid sensory histidine kinase BarA; Provisional

Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 55.63 E-value: 1.15e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 552 AGVAHEIRNPLTTLRGFLQLQQQTQ--SVNADHIDLMlsELDRINL--IVSEFLILAKPQA-------IHFQERDVrgiL 620
Cdd:PRK11107  298 ANMSHELRTPLNGVIGFTRQTLKTPltPTQRDYLQTI--ERSANNLlaIINDILDFSKLEAgklvlenIPFSLRET---L 372

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 621 RDVISFLDSQAHLYGVEVKLDFSPE-PALVHCEENQLKQVFINLLKNAFEAMPDGGT-VTITLKRPGGDHVLITIQ--DE 696
Cdd:PRK11107  373 DEVVTLLAHSAHEKGLELTLNIDPDvPDNVIGDPLRLQQIITNLVGNAIKFTESGNIdILVELRALSNTKVQLEVQirDT 452

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1148848711 697 GHGIPEELMPHLGEPF------ITNKETGTGLGLMVSQRIIQGHQGTLEIESKSGVGT 748
Cdd:PRK11107  453 GIGISERQQSQLFQAFrqadasISRRHGGTGLGLVITQKLVNEMGGDISFHSQPNRGS 510

dpiB

PRK15053

sensor histidine kinase DpiB; Provisional

554-762

1.70e-07

sensor histidine kinase DpiB; Provisional

Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 54.45 E-value: 1.70e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 554 VAHEIRNPLTTLRGFLQLQqqtqsvnadhidlmlsELDRINLIVS------EFLILAKPQAihFQERDVRGILRDVISfl 627
Cdd:PRK15053  345 LRHEHLNWMSTLNGLLQMK----------------EYDRVLEMVQgesqaqQQLIDSLREA--FADRQVAGLLFGKVQ-- 404

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 628 dsQAHLYGVevKLDFSPEPAL----VHCEENQLKQVFINLLKNAFEA---MPDGGTVTITLKRPGGDHVLITIQDEGHGI 700
Cdd:PRK15053  405 --RARELGL--KMVIVPGSQLsqlpPGLDSTEFAAIVGNLLDNAFEAslrSDEGNKIVELFLSDEGDDVVIEVADQGCGV 480

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1148848711 701 PEELMPHLGEPFITNK--ETGT-GLGLMVSQRIIQGHQGTLEIESKSGVGTKISIVLPAARRQSD 762
Cdd:PRK15053  481 PESLRDKIFEQGVSTRadEPGEhGIGLYLIASYVTRCGGVITLEDNDPCGTLFSIFIPKVKPNDS 545

PRK13559

hypothetical protein; Provisional

426-757

4.18e-07

hypothetical protein; Provisional

Pssm-ID: 237427 [Multi-domain] Cd Length: 361 Bit Score: 52.90 E-value: 4.18e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 426 QTADAIHTTDTHER---VISVNNAFEQLYGWKANEVIGQKLE-LVPPSKLDEERDRLRRLREGERLPPVETVRMRKDGSL 501
Cdd:PRK13559   51 QTRMAMCITDPHQPdlpIVLANQAFLDLTGYAAEEVVGRNCRfLQGAATDPIAVAKIRAAIAAEREIVVELLNYRKDGEP 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 502 IEVSISTSLVRDEQGQVTSMISVSRDVTERNRIEElLRRSEKlntvgQLAAGVAHEIRNPLTTLRGFLQLqqqtqSVNAD 581
Cdd:PRK13559  131 FWNALHLGPVYGEDGRLLYFFGSQWDVTDIRAVRA-LEAHER-----RLAREVDHRSKNVFAVVDSIVRL-----TGRAD 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 582 HIDLMLSEL-DRINLIVSEFL-ILAKPqaiHFQERDVRGILRDVISFLDSQAH---LYGVEVKLDfspePALVHCEENQL 656
Cdd:PRK13559  200 DPSLYAAAIqERVQALARAHEtLLDER---GWETVEVEELIRAQVAPYAPRATrvaFEGPGIRLG----AASVQPLGLVL 272

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 657 KQVFINLLKNAFEAMPDgGTVTITLK-RPGGDHVLITIQDEGHGIPEELmphlgepfitnKETGTGlGLMVSQRIIQGHQ 735
Cdd:PRK13559  273 HELAVNAIKHGALSADQ-GRISISWKpSPEGAGFRIDWQEQGGPTPPKL-----------AKRGFG-TVIIGAMVESQLN 339

                         330       340
                  ....*....|....*....|..
gi 1148848711 736 GTLEIESkSGVGTKISIVLPAA 757
Cdd:PRK13559  340 GQLEKTW-SDDGLLARIEIPSR 360

ComP

COG4585

Signal transduction histidine kinase ComP [Signal transduction mechanisms];

615-759

6.21e-07

Signal transduction histidine kinase ComP [Signal transduction mechanisms];

Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 51.54 E-value: 6.21e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 615 DVRGILRDVISFLDSQAHLYGVEVKLDFSPEPALVHceenqlKQVFINLLKNAFEAM------PDGGTVTITLKRpGGDH 688
Cdd:COG4585   121 DDLGLAAALEELAERLLRAAGIRVELDVDGDPDRLP------PEVELALYRIVQEALtnalkhAGATRVTVTLEV-DDGE 193

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1148848711 689 VLITIQDEGHGIPEELMPhlgepfitnketGTGLGLMVSQRIIQGHQGTLEIESKSGVGTKISIVLPAARR 759
Cdd:COG4585   194 LTLTVRDDGVGFDPEAAP------------GGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPLAAA 252

PAS_4

pfam08448

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...

425-531

9.67e-07

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain is associated to signalling systems and works as a signal sensor domain. It recognizes differently substituted aromatic hydrocarbons, oxygen, different dodecanoic acids, autoinducers, 3,5-dimethyl-pyrazin-2-ol and N-alanyl-aminoacetone (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).

Pssm-ID: 312075 [Multi-domain] Cd Length: 110 Bit Score: 48.18 E-value: 9.67e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 425 NQTADAIHTTDTHERVISVNNAFEQLYGWKANEVIGQKLELVPPSKLDEERDRLRRLREGERLPPVETVRMRKDGSLIEV 504
Cdd:pfam08448   2 DSLPDALAVLDPDGRVRYANAAAAELFGLPPEELLGKTLAELLPPEDAARLERALRRALEGEEPIDFLEELLLNGEERHY 81

                          90       100
                  ....*....|....*....|....*..
gi 1148848711 505 SISTSLVRDEQGQVTSMISVSRDVTER 531
Cdd:pfam08448  82 ELRLTPLRDPDGEVIGVLVISRDITER 108

PRK13560

hypothetical protein; Provisional

378-541

2.35e-06

hypothetical protein; Provisional

Pssm-ID: 106506 [Multi-domain] Cd Length: 807 Bit Score: 51.21 E-value: 2.35e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 378 EVTSRDELGQLAGRINAMTRNLGHYTSQLKQMVEENQsvkeyLESIINQTADAIHTTDTHERVISV-NNAFEQLYGWKAN 456
Cdd:PRK13560  297 HAEFDDKENHCAGLVGAITDISGRRAAERELLEKEDM-----LRAIIEAAPIAAIGLDADGNICFVnNNAAERMLGWSAA 371

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 457 EVIGQKLELVPPSKLDEERDRLRRLREGERLPP-------------------VETVRMRKDGSLIEVSISTSLVRDEQGQ 517
Cdd:PRK13560  372 EVMGKPLPGMDPELNEEFWCGDFQEWYPDGRPMafdacpmaktikggkifdgQEVLIEREDDGPADCSAYAEPLHDADGN 451

                         170       180
                  ....*....|....*....|....
gi 1148848711 518 VTSMISVSRDVTERNRIEELLRRS 541
Cdd:PRK13560  452 IIGAIALLVDITERKQVEEQLLLA 475

HATPase_EL346-LOV-HK-like

cd16951

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

656-755

3.02e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.

Pssm-ID: 340427 [Multi-domain] Cd Length: 131 Bit Score: 47.03 E-value: 3.02e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 656 LKQVFINLLKNAFEAMpDGGTVTITLKRpGGDHVLITIQDEGHGIPEELMPHlgepfitNKETgtgLGLMVSQRIIQGHQ 735
Cdd:cd16951    44 VNELLQNALKHAFSDR-EGGTITIRSVV-DGDYLRITVIDDGVGLPQDEDWP-------NKGS---LGLQIVRSLVEGEL 111

                          90       100
                  ....*....|....*....|
gi 1148848711 736 GTLEIESKSGVGTKISIVLP 755
Cdd:cd16951   112 KAFLEVQSAENGTRVNIDIP 131

HATPase_CheA-like

cd16916

Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ...

675-755

4.83e-06

Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.

Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 47.58 E-value: 4.83e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 675 GTVTITLKRPGGdHVLITIQDEGHGI------------------------PEELMPHLGEP-FITNKE----TGTGLGLM 725
Cdd:cd16916    70 GTITLRAEHQGN-QVVIEVSDDGRGIdrekirekaierglitadeaatlsDDEVLNLIFAPgFSTAEQvtdvSGRGVGMD 148

                          90       100       110
                  ....*....|....*....|....*....|
gi 1148848711 726 VSQRIIQGHQGTLEIESKSGVGTKISIVLP 755
Cdd:cd16916   149 VVKRSIESLGGTIEVESEPGQGTTFTIRLP 178

HATPase_VanS-like

cd16923

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

656-742

1.07e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.

Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 44.68 E-value: 1.07e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 656 LKQVFINLLKNAFEAMPDGGTVTITLKRPGgDHVLITIQDEGHGIPEELMPHLGEPF----ITNKETGTGLGLMVSQRII 731
Cdd:cd16923     1 LQRVFSNLLSNAIKYSPENTRIYITSFLTD-DVVNIMFKNPSSHPLDFKLEKLFERFyrgdNSRNTEGAGLGLSIAKAII 79

                          90
                  ....*....|.
gi 1148848711 732 QGHQGTLEIES 742
Cdd:cd16923    80 ELHGGSASAEY 90

PAS

smart00091

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...

418-468

1.55e-05

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.

Pssm-ID: 214512 Cd Length: 67 Bit Score: 43.16 E-value: 1.55e-05

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1148848711  418 EYLESIINQTADAIHTTDTHERVISVNNAFEQLYGWKANEVIGQKL-ELVPP 468
Cdd:smart00091   1 ERLRAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLlELIHP 52

HATPase_UhpB-NarQ-NarX-like

cd16917

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

662-755

2.43e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.

Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 43.31 E-value: 2.43e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 662 NLLKNAfeampDGGTVTITLKRpGGDHVLITIQDEGHGIPEELMPHlgepfitnketGTGLGLMvsqriiqGHQ------ 735
Cdd:cd16917    11 NALKHA-----GASRVRVTLSY-TADELTLTVVDDGVGFDGPAPPG-----------GGGFGLL-------GMReraell 66

                          90       100
                  ....*....|....*....|.
gi 1148848711 736 -GTLEIESKSGVGTKISIVLP 755
Cdd:cd16917    67 gGTLTIGSRPGGGTRVTARLP 87

HATPase_YpdA-like

cd16955

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

674-755

4.15e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.

Pssm-ID: 340431 [Multi-domain] Cd Length: 102 Bit Score: 43.22 E-value: 4.15e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 674 GGTVTITLKRPGGDHVLITIQDEGHGIPEELMphlgEPFITNKETGTGLGLM-VSQRIIQGHQGTLEIESKSGVGTKISI 752
Cdd:cd16955    24 KGVVKISVKKQLKNRLHIAVEDNGIGISPKVI----ERVEQDEMPGNKIGLLnVHQRLKLGYGEGLHIRSRPDPGTLIAF 99


                  ...
gi 1148848711 753 VLP 755
Cdd:cd16955   100 YIP 102

PAC

smart00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); PAC motif ...

495-531

4.96e-05

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); PAC motif occurs C-terminal to a subset of all known PAS motifs. It is proposed to contribute to the PAS domain fold.

Pssm-ID: 197509 Cd Length: 43 Bit Score: 41.01 E-value: 4.96e-05

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1148848711  495 MRKDGSLIEVSISTSLVRDEQGQVTSMISVSRDVTER 531
Cdd:smart00086   7 RRKDGSYIWVLVSASPIRDEDGEVEGILGVVRDITER 43

PAS_8

pfam13188

PAS domain; PAS domains are involved in many signalling proteins where they are used as a ...

418-468

5.40e-05

PAS domain; PAS domains are involved in many signalling proteins where they are used as a signal sensor domain. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. This domain recognizes oxygen and CO (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).

Pssm-ID: 463802 [Multi-domain] Cd Length: 65 Bit Score: 41.77 E-value: 5.40e-05

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1148848711 418 EYLESIINQTADAIHTTDTHERVISVNNAFEQLYGWKA-NEVIGQKLELVPP 468
Cdd:pfam13188   1 ERLRALFESSPDGILVLDEGGRIIYVNPAALELLGYELlGELLGELLDLLDP 52

RsbW

COG2172

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];

660-725

5.81e-05

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];

Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 43.36 E-value: 5.81e-05

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1148848711 660 FINLLKNAFEAMPDGgTVTITLkRPGGDHVLITIQDEGHGIPEElmpHLGEPFITNKETGTGLGLM 725
Cdd:COG2172    43 VTNAVRHAYGGDPDG-PVEVEL-ELDPDGLEIEVRDEGPGFDPE---DLPDPYSTLAEGGRGLFLI 103

CheA

COG0643

Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];

675-755

5.82e-05

Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];

Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 46.33 E-value: 5.82e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 675 GTVTITLKRPGGdHVLITIQDEGHGI------------------------PEELMPHLGEP-FITNKE-T---GTGLGLM 725
Cdd:COG0643   309 GTITLSAYHEGG-RVVIEVSDDGRGLdlekirakaiekglitaeeaaalsDEELLELIFAPgFSTAEEvTdlsGRGVGMD 387

                          90       100       110
                  ....*....|....*....|....*....|
gi 1148848711 726 VSQRIIQGHQGTLEIESKSGVGTKISIVLP 755
Cdd:COG0643   388 VVKTNIEALGGTIEIESEPGKGTTFTLRLP 417

PRK13560

hypothetical protein; Provisional

419-542

1.09e-04

hypothetical protein; Provisional

Pssm-ID: 106506 [Multi-domain] Cd Length: 807 Bit Score: 45.82 E-value: 1.09e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 419 YLESIINQTADAIHTTDTHERVISVNNAFEQLYGWKANEVIGQKL-ELVPPSKLDEERDRLRRLREGERLPPVETVRMRK 497
Cdd:PRK13560  205 FLQQLLDNIADPAFWKDEDAKVFGCNDAACLACGFRREEIIGMSIhDFAPAQPADDYQEADAAKFDADGSQIIEAEFQNK 284

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1148848711 498 DGSL--IEVSISTSLVRDEQGQVTSMISVSRDVTERNRIEELLRRSE 542
Cdd:PRK13560  285 DGRTrpVDVIFNHAEFDDKENHCAGLVGAITDISGRRAAERELLEKE 331

PRK10935

nitrate/nitrite two-component system sensor histidine kinase NarQ;

329-412

2.72e-04

nitrate/nitrite two-component system sensor histidine kinase NarQ;

Pssm-ID: 236800 [Multi-domain] Cd Length: 565 Bit Score: 44.46 E-value: 2.72e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 329 MISLVAISLV-LLEIVIFGSYIVagYFTK-----PIQSILRTVNDVADGHFDR-RLEVTSRDELGQLAGRINAMTRNLGH 401
Cdd:PRK10935  147 LILLAAISLLgLILILTLVFFTV--RFTRrqvvaPLNQLVTASQQIEKGQFDHiPLDTTLPNELGLLAKAFNQMSSELHK 224

                          90
                  ....*....|.
gi 1148848711 402 YTSQLKQMVEE 412
Cdd:PRK10935  225 LYRSLEASVEE 235

HATPase_TopVIB-like

cd16933

Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family ...

656-707

4.57e-04

Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family includes the histidine kinase-like ATPase (HATPase) domain of the B subunit of topoisomerase VI (Topo VIB). Topo VI is a heterotetrameric complex composed of two TopVIA and two TopVIB subunits and is categorized as a type II B DNA topoisomerase. It is found in archaea and also in plants. Type II enzymes cleave both strands of a DNA duplex and pass a second duplex through the resulting break in an ATP-dependent mechanism. DNA cleavage by Topo VI generates two-nucleotide 5'-protruding ends.

Pssm-ID: 340410 [Multi-domain] Cd Length: 203 Bit Score: 42.34 E-value: 4.57e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1148848711 656 LKQVFINLLKNAFEAMPDGG---TVTITLKRPGGDHVLITIQDEGHGIPEELMPH 707
Cdd:cd16933    20 LYTTVRELVENSLDATEEAGilpDIKVEIEEIGKDHYKVIVEDNGPGIPEEQIPK 74

HATPase_AgrC-ComD-like

cd16935

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...

619-746

2.04e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.

Pssm-ID: 340412 [Multi-domain] Cd Length: 134 Bit Score: 39.10 E-value: 2.04e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 619 ILRDVISFLDSQAHLYGVEVKLDFsPEPALVHCEENQLKQVFINLLKNAFEA---MPDGG---TVTITLKrpgGDHVLIT 692
Cdd:cd16935     1 ALDSLLSEKLELAREKGIEFTIEI-DIPILLPISPLDLCIIFGNLLDNAIEAcakIDKENrfiHLKIRQK---KGFLIIS 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1148848711 693 IQDeghGIPEELMPHLGEPFITNKETGTGLGLMVSQRIIQGHQGTLEIESKSGV 746
Cdd:cd16935    77 IEN---SYEGELKKKNGLFLSTKKDKNHGIGLKSIREIVKKYNGNLSIEYENGI 127

PRK10618

phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional

676-764

2.42e-03

phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional

Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 41.46 E-value: 2.42e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 676 TVTITLKRPGGDHVLITIQDEGHGIPEELMPHLGEPFITNKE-----TGTGLGLMVSQRIIQGHQGTLEIESKSGVGTKI 750
Cdd:PRK10618  587 TLEVDQDESSPDRLTIRILDTGAGVSIKELDNLHFPFLNQTQgdrygKASGLTFFLCNQLCRKLGGHLTIKSREGLGTRY 666

                          90
                  ....*....|....
gi 1148848711 751 SIVLPAARRQSDME 764
Cdd:PRK10618  667 SIHLKMLAADPEVE 680

PRK10547

chemotaxis protein CheA; Provisional

718-755

4.07e-03

chemotaxis protein CheA; Provisional

Pssm-ID: 236712 [Multi-domain] Cd Length: 670 Bit Score: 40.48 E-value: 4.07e-03

                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1148848711 718 TGTGLGLMVSQRIIQGHQGTLEIESKSGVGTKISIVLP 755
Cdd:PRK10547  485 SGRGVGMDVVKRNIQEMGGHVEIQSKQGKGTTIRILLP 522

HATPase_Phy-like

cd16932

Histidine kinase-like ATPase domain of plant phytochromes similar to Arabidopsis thaliana ...

656-739

7.82e-03

Histidine kinase-like ATPase domain of plant phytochromes similar to Arabidopsis thaliana Phytochrome A, B, C, D and E; This family includes the histidine kinase-like ATPase (HATPase) domains of plant red/far-red photoreceptors, the phytochromes, and includes the Arabidopsis thaliana phytochrome family phyA-phyE. Following red light absorption, biologically inactive forms of phytochromes convert to active forms, which rapidly convert back to inactive forms upon far-red light irradiation. Phytochromes can be considered as having an N-terminal photosensory region to which a bilin chromophore is bound, and a C-terminal output region, which includes the HATPase domain represented here, and is involved in dimerization and presumably contributes to relaying the light signal to downstream signaling events.

Pssm-ID: 340409 [Multi-domain] Cd Length: 113 Bit Score: 36.87 E-value: 7.82e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 656 LKQVFINLLKNAFEAMP-DGGTVTI----TLKRPG-GDHVL---ITIQDEGHGIPEELMPhlgEPFITNKE-TGTGLGLM 725
Cdd:cd16932     7 LQQVLADFLLNAVRFTPsPGGWVEIkvspTKKQIGdGVHVIhleFRITHPGQGLPEELVQ---EMFEENQWtTQEGLGLS 83

                          90
                  ....*....|....
gi 1148848711 726 VSQRIIQGHQGTLE 739
Cdd:cd16932    84 ISRKLVKLMNGDVR 97

PRK10600

nitrate/nitrite two-component system sensor histidine kinase NarX;

325-412

9.74e-03

nitrate/nitrite two-component system sensor histidine kinase NarX;

Pssm-ID: 182581 [Multi-domain] Cd Length: 569 Bit Score: 39.27 E-value: 9.74e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1148848711 325 MREQMISLV-----AISLVLLEIVIFgsYIVAGYFTkPIQSILRTVNDVADGHFDRRLEVTSRDELGQLAGRINAMTRNL 399
Cdd:PRK10600  118 MRIETVVLVhrvfaVFMALLLVFTII--WLRRRLLQ-PWRQLLSMANAVSHRDFTQRANISGRDEMAMLGTALNNMSAEL 194

                          90
                  ....*....|...
gi 1148848711 400 GHYTSQLKQMVEE 412
Cdd:PRK10600  195 AESYAVLEQRVQE 207

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01