|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
33-387 |
3.40e-82 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 255.19 E-value: 3.40e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 33 RRLIPFLMLCYLGAYLDRVNVGFAKLQMLNDLHFSETVYGMGAGIFFLGYFLFEVPSNLILHRVGARRWLARIMLTWAVI 112
Cdd:cd17319 2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 113 SASFVFVKSPTAFYVLRFALGVAEAGFAPGVILYLTYWFPSARRAKALSLFFMAIPLAGIIGGPLSGAIMHslhgamsMA 192
Cdd:cd17319 82 TALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLL-------LF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 193 GWKWLFLLEALPSFVLGFAILLYLddgiagakwltdaekallarnvsadaahttahlsirtfvadRRLWLMAAIYFCVVL 272
Cdd:cd17319 155 GWRWAFIIEGLLGLLLAVLWWFYL-----------------------------------------RQVWGLALGYFGINY 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 273 GQYGLTFWLPTIIRKAGVADPLWVGLFTAIPYACAIVALPLIGISADR--RRERRFHLAVPMLVAAAGFATLPMLGSVAA 350
Cdd:cd17319 194 ALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRllRGARRLVIIIGLLLAAVGLLLAYLTTSPVV 273
|
330 340 350
....*....|....*....|....*....|....*..
gi 1147533804 351 SIVCLSIASAGILASSSQFWSLPTALLGGMSAAAGIA 387
Cdd:cd17319 274 AVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGG 310
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
41-387 |
1.27e-75 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 239.55 E-value: 1.27e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 41 LCYLGAYLDRVNVGFAKLQMLNDLHFSETVYGMGAGIFFLGYFLFEVPSNLILHRVGARRWLARIMLTWAVISASFVFVK 120
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 121 SPTAFYVLRFALGVAEAGFAPGVILYLTYWFPSARRAKALSLFFMAIPLAGIIGGPLSGAIMHslhgamsMAGWKWLFLL 200
Cdd:TIGR00893 81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILI-------HFSWQWAFII 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 201 EALPSFVLGFAILLYLDDGIAGAKWLTDAEKALLARNVSADAA----HTTAHLSIRTFVADRRLWLMAAIYFCVVLGQYG 276
Cdd:TIGR00893 154 EGVLGIIWGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQQgkgpSTPKKYQIKELLKDRRVWGLALGQFLVNIGLGF 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 277 LTFWLPTIIRKAGVADPLWVGLFTAIPYACAIVALPLIGISADRRRERRFHLAVPMLVAAAGFATLPML----GSVAASI 352
Cdd:TIGR00893 234 FLTWFPTYLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFARKTAIIAGLVLSLLmfatNYVNIPY 313
|
330 340 350
....*....|....*....|....*....|....*..
gi 1147533804 353 VCLSIASAGI--LASSSQFWSLPTALLGGMSAAAGIA 387
Cdd:TIGR00893 314 AALALVALGFfgLGAGAIGWALISDNAPGNIAGLTGG 350
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
34-371 |
3.02e-57 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 192.08 E-value: 3.02e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 34 RLIPFLMLCYLGAYLDRVNVGFAKLQ-MLNDLHFSETVYGMGAGIFFLGYFLFEVPSNLILHRVGARRWLARIMLTWAVI 112
Cdd:cd17327 5 FILPLLCILYFLQYLDKSNISNAAVMgMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 113 SASFVFVKSPTAFYVLRFALGVAEAGFAPGVILYLTYWFPSARRAKALSLFFMAIPLAGIIGGPLSGAIMHSlHGAMSMA 192
Cdd:cd17327 85 TLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKI-LGVGGLA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 193 GWKWLFLLEALPSFVLGFAILLYLDDGIAGAKWLTDAEKALLARNVSADAAHTTAHLS----IRTFVADRRLWLMAAIYF 268
Cdd:cd17327 164 GWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVERLRANQTGKGDQKFkwkqIKEAFKDPRTWLLFLFFF 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 269 CVVLGQYGLTFWLPTIIrKAGVADPLWVGLFTAIPYACAIVALPLIGISADRRRERRFHLAVPMLVAAAGFATLPMLGSV 348
Cdd:cd17327 244 CSQITNNGISNFLPLIL-KSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFACVLALVGSIILLAAPNP 322
|
330 340
....*....|....*....|...
gi 1147533804 349 AASIVCLSIASAGILASSSQFWS 371
Cdd:cd17327 323 PGAYFAAYILGGGSYAGFPILLS 345
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
25-387 |
2.87e-52 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 177.75 E-value: 2.87e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 25 AATYAKVARRLIPFLMLCYLGAYLDRVNVGFAKLQMLNDLHFSETVYGMGAGIFFLGYFLFEVPSNLILHRVGARRWLAR 104
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 105 IMLTWAVISASFVFVKSPTAFYVLRFALGVAEAGFAPGVILYLTYWFPSARRAKALSLFFMAIPLAGIIGGPLSGAIMHS 184
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 185 LhgamsmaGWKWLFLLEALPSFVLGFAillylddgiagakwltdaekallarnvsadaahttahlsirtfvadrRLWLMA 264
Cdd:COG2271 161 F-------GWRAAFLILGLPGLLLALL-----------------------------------------------RFWLLA 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 265 AIYFCVVLGQYGLTFWLPTIIRKAGVADPLWVGLFTAIPYACAIVALPLIGISADR-RRERRFHLAVPMLVAAAGFATLP 343
Cdd:COG2271 187 LAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRlGRRRKLVLAIGLLLAALALLLLA 266
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1147533804 344 MLGSVAASIVCLSIASAGILASSSQFWSLPTALLGGMSAAAGIA 387
Cdd:COG2271 267 LLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASG 310
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
30-387 |
9.19e-33 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 126.53 E-value: 9.19e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 30 KVARRLIPFLMLCYLGAYLDRVNVGFAKLQMLNDLHFSETVYGMGAGIFFLGYFLFEVPSNLILHRVGARRWLARIMLTW 109
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 110 AVISASFVFVKSPTAFYVLRFALGVAEAGFAPGVILYLTYWFPSARRAKALSLFFMAIPLAGIIGGPLSGAIMHSLhgam 189
Cdd:COG2223 81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF---- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 190 smaGWKWLFLLEALPSFVLGFAILLYLDDGIAGAKwltdaekallarnvsadAAHTTAHLSIRTFVADRRLWLMAAIYFC 269
Cdd:COG2223 157 ---GWRNAFLILGILLLVVAVLAWLFLRDPPAGAA-----------------AAAKASLRDQLEALRDPRFWLLSLLYFG 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 270 VVLGQYGLTFWLPTIIRKAGVADPLWVGLFTAIPYACAIVALPLIGISADRRRERRFHLAVPMLVAAAGFATLPMLGSVA 349
Cdd:COG2223 217 TFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLW 296
|
330 340 350
....*....|....*....|....*....|....*...
gi 1147533804 350 ASIVCLSIASAGILASSSQFWSLPTALLGGMSAAAGIA 387
Cdd:COG2223 297 LFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYG 334
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
26-387 |
6.45e-23 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 98.51 E-value: 6.45e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 26 ATYAKVARRLIPFLMLCYLGAYLDRVNVGFAKLQMLNDLHFSETVYGMGAGIFFLGYFLFEVPSNLILHRVGARRWLARI 105
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 106 MLTWAVISASFVFVKSPTAFYVLRFALGVAEAGFAPGVILYLTYWFPSARRAKALSLFFMAIPLAGIIGGPLSGAIMHSL 185
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 186 hgamsmaGWKWLFLLEALPSFVLGFAILLYLDDgiagakwltdaekallarnvSADAAHTTAHLSIRTFVADRRLWLMAA 265
Cdd:COG2814 162 -------GWRWVFLVNAVLALLALLLLLRLLPE--------------------SRPAARARLRGSLRELLRRPRLLLLLL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 266 IYFCVVLGQYGLTFWLPTIIRKAGVADPLWVGLFTAIPYACAIVALPLIGISADRRRERRFhLAVPMLVAAAGFATLPML 345
Cdd:COG2814 215 LAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRL-LLIGLLLLALGLLLLALA 293
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1147533804 346 GSVAASIVCLSIASAGILASSSQFWSLPTALLGGMSAAAGIA 387
Cdd:COG2814 294 GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASG 335
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
39-387 |
8.33e-23 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 98.65 E-value: 8.33e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 39 LMLCYLGAYLDRVNVGFAKLQMLNDLHFSETVYGMGAGIFFLGYFLFEVPSNLILHRVGARRWLARIMLTWAVISASFVF 118
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 119 VKSPTAFYVLRFALGVAEAGFAPGVILYLTYWFPSARRAKALSLFFMAIPLAGIIGGPLSGAIMHSLhgamsMAGWKWLF 198
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSL-----GFGWRAVF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 199 LLEALPSFVLGFAILLYLDDgiagakwltdaeKALLARNVSADAAHTTAHLSIRTFVADRRLWLMAAIYFCVVLGQYGLT 278
Cdd:cd06174 156 LIAAALALLAAILLLLVVPD------------PPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFS 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 279 FWLPTIIRKAGVADPLWVGLFTAIPYACAIVALPLIGISADRRRERRFHLAVPMLVAAAGFATLPMLGSVAASIVCLSIA 358
Cdd:cd06174 224 TLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLL 303
|
330 340
....*....|....*....|....*....
gi 1147533804 359 SAGILASSSQFWSLPTALLGGMSAAAGIA 387
Cdd:cd06174 304 GFGLGGLLPLSFALIAELFPPEIRGTAFG 332
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
39-387 |
3.37e-21 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 93.64 E-value: 3.37e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 39 LMLCYLGAYLDRVNVGFA-KLQMLNDLHFSETVYGMGAGIFFLGYFLFEVPSNLILHRVGARRWLARIMLTWAVISASFV 117
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPAlPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 118 FVKSPTAFYVLRFALGVAEAGFAPGVILYLTYWFPSARRAKALSLFFMAIPLAGIIGGPLSGAIMHSLhgamsmaGWKWL 197
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF-------GWRAA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 198 FLLEALPSFVLGFAILLYLDdgiagakwltdaeKALLARNVSADAAHTTAHLSIRTFVADRRLWLMAAIyFCVVLGQYGL 277
Cdd:pfam07690 154 FLILAILSLLAAVLLLLPRP-------------PPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLAL-LLFGFAFFGL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 278 TFWLPTIIRKAGVaDPLWVGLFTAIPYACAIVALPLIGISADR--RRERRFHLAVPMLVAAAGFATLPMLGSVAASIVCL 355
Cdd:pfam07690 220 LTYLPLYQEVLGL-SALLAGLLLGLGGLLGAIGRLLLGRLSDRlgRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLAL 298
|
330 340 350
....*....|....*....|....*....|..
gi 1147533804 356 SIASAGILASSSQFWSLPTALLGGMSAAAGIA 387
Cdd:pfam07690 299 LLLGFGFGLVFPALNALVSDLAPKEERGTASG 330
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
63-362 |
1.75e-16 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 79.93 E-value: 1.75e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 63 DLHFSETVYGMGAGIFFLGYFLFEVPSNLILHRVGARRWLARIMLTWAVISASFVFVKSPTAFYVLRFALGVAEAGFAPG 142
Cdd:cd17325 25 SLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 143 VILYLTYWFPSARRAKALSLFFMAIPLAGIIGGPLSGAIMHSLhgamsmaGWKWLFLLEALPSFVLGFAILLYLDDGIAG 222
Cdd:cd17325 105 AMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL-------GYRAPFLVCAALALLALVLALLLLPEPRPP 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 223 AKwltdaekallarnvSADAAHTTAHLSIRTFVADRRLWLMAAIYFCVVLGQYGLTFWLPTIIRKAGVADPLWVGLFTAI 302
Cdd:cd17325 178 PN--------------KRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGA 243
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 303 PYACAIVALPLIGISADRRRERRFhLAVPMLVAAAGFATLPMLGSVAASIVCLSIASAGI 362
Cdd:cd17325 244 QGLASALSQPPAGKLSDRIGRKPL-ILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGL 302
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
38-371 |
5.75e-16 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 78.37 E-value: 5.75e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 38 FLMLCYLgaYLDRVNVGFAKLQMLNDLHFSETVYGMGAGIFFLGYFLFEVPSNLILHRVGARRWLARIMLTWAVISASFV 117
Cdd:cd17380 5 FLATCIC--YADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 118 FVKSPT--AFYVLRFALGVAEAGFAPGVILYLTYWFPSARRAKALSLFFMAIPLAGIIGGPLSGAIMHslhgamsMAGWK 195
Cdd:cd17380 83 LLAYSSlpLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLE-------YYGWP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 196 WLFLLEALPSFVLGFAILLYLddgiagakwltdaekallarnvsadaahttahlsirtfvadRRLWLMAAIYFCVVLGQY 275
Cdd:cd17380 156 SVFYFFGLLGLLWALVWLIYL-----------------------------------------PPVWAIIVAHFCMNWGFY 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 276 GLTFWLPTIIRKAGVADPLwVGLFTAIPYACAIVALPLIGISADRRRERRFHLA--------VPMLVAAAGFATLPMLGS 347
Cdd:cd17380 195 ILLSWLPTYFHEVLVPLAK-GWVFNVVPWLVMFPSSNVAGWLADHLISRGWTVTsvrklmqsIGFLGPALFLLLLSHTDS 273
|
330 340
....*....|....*....|....
gi 1147533804 348 VAASIVCLSIASAGILASSSQFWS 371
Cdd:cd17380 274 FSLALLCMSVALGLSAFSSSGVLV 297
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
43-384 |
7.05e-15 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 75.49 E-value: 7.05e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 43 YLGAYLDRVNVGFAKLQMLNDLHFSETVYGMGAGIFFLGYFLFEVPSNLILHRVGARRWLARIMLTWAVISASFVFVKSP 122
Cdd:TIGR00881 4 YAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 123 TAFYVLRFALGVAEAGFAPGVILYLTYWFPSARRAKALSLFFMAIPLAGIIGGPLSGAIMHslhgamSMAGWKWLFLLEA 202
Cdd:TIGR00881 84 WVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIA------ELYSWHWVFIVPG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 203 LPSFVLGFAILLYLDDGIAgAKWLTDAE----KALLARNVSADAAHTTAHLSIRTFVADRRLWLMAAIYFCVVLGQYGLT 278
Cdd:TIGR00881 158 IIAIIVSLICFLLLRDSPQ-SCGLPPAEempnEEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGIL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 279 FWLPTIIRKAGVADPLWVGLFTAIPYACAIVALPLIGISADRR-RERRFHLAV----PMLVAAAGFaTLPMLGSVAASIV 353
Cdd:TIGR00881 237 DWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLfNGRRGPLAVffmaLIIVSLLVY-WLNPAANPLMDLI 315
|
330 340 350
....*....|....*....|....*....|..
gi 1147533804 354 CLsiASAGILASSSQF-WSLPTALLGGMSAAA 384
Cdd:TIGR00881 316 CL--FALGFLVYGPQMlIGVIASELAPKKAAG 345
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
39-362 |
1.90e-14 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 74.19 E-value: 1.90e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 39 LMLCYLGAYLDRVNVGFAKLQMLNDLHFSETVYGMGAGIFFLGYFLFEVPSNLILHRVGaRRWLARI-MLTWAVISASFV 117
Cdd:cd17328 4 LFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYN-RKWILAVgILIWSAATLLSS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 118 FVKSPTAFYVLRFALGVAEAGFAPGVILYLTYWFPSARRAKALSLFFMAIPLAGIIGGPLSGAImhslhgAMSMAGWKWL 197
Cdd:cd17328 83 FAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLV------AQATGGWRWA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 198 FLLEALPSFVLGFAILLYLDDGIAGAkwltDAEKALLARNVSADAAHTTAHLSIRTFvadrrlWLMAAIYFCVVLGQYGL 277
Cdd:cd17328 157 FRVTGVLGVLLAILLLLFVREPPRGA----AEGGVMAKSTATSFLADLKALAKNPSF------ILSTLGFTAVSFVTGAL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 278 TFWLPTIIRKAGVADP-------LWVGLFTAIpyaCAIVALPLIGISADRRRERR-----FHLAVPMLVAA--AGFATLP 343
Cdd:cd17328 227 AFWAPTFFLRAFGVGDlssadvgLIFGAITCI---AGVLGVLLGGILADRLRRKTpradpLVCAVGLLAAApfLFLALVL 303
|
330
....*....|....*....
gi 1147533804 344 MLGSVAASIVCLSIASAGI 362
Cdd:cd17328 304 ALSNLLLAWVLLFLGEFLL 322
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
59-384 |
2.03e-14 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 74.14 E-value: 2.03e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 59 QMLNDLHFSETVYGMGAGIFFLGYFLFEVPSNLILHRVGARRWLARIMLTWAVISASFVFVKSPTAFYVLRFALGVAEAG 138
Cdd:COG2807 43 EIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAV 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 139 FAPGVILYLTYWFPsARRAKALSLFFMAIPLAGIIGGPLSGAIMHSLhgamsmaGWKWLFLLEALPSFVLGFAILLyldd 218
Cdd:COG2807 123 GNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAAL-------GWRGALAVWALLALLALLLWLP---- 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 219 giagakwltdaekalLARNVSADAAHTTAHLSIRTFVADRRLWLMAAIYFCVVLGQYGLTFWLPTIIRKAGVaDPLWVGL 298
Cdd:COG2807 191 ---------------LLRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGL-SAATAGL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 299 FTAIPYACAIVALPLIGISADRRRERRFHLAVPMLVAAAGFATLpMLGSVAASIVCLSIASAGILASSSQFWSLPTALLG 378
Cdd:COG2807 255 LLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGL-LLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRAR 333
|
....*.
gi 1147533804 379 GMSAAA 384
Cdd:COG2807 334 TPAEAA 339
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
59-385 |
2.15e-14 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 73.74 E-value: 2.15e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 59 QMLNDLHFSETVYGMGAGIFFLGYFLFEVPSNLILHRVGARRWLARIMLTWAVISASFVFVKSPTAFYVLRFALGVAEAG 138
Cdd:cd17324 24 DIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 139 FAPGVILYLTYWFPSARRAKALSLFFMAIPLAGIIGGPLSGAImhslhgaMSMAGWKWLFLLEALPSFVLGFAILLyldd 218
Cdd:cd17324 104 FWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLL-------GQLLGWRAAFLAIAVLALLAALLLWR---- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 219 giagakwltdaekaLLARNVSADAAHTTAHLSIRTFVADRRLWLMAAIYFCVVLGQYGLTFWLPTIIRKAGVADPLWVGL 298
Cdd:cd17324 173 --------------LLPSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 299 FTAIPYACAIVALPLIGISADRRReRRFHLAVPMLVAAAGFATLPMLGSVAASIVCLSIASAGILASSSQFWSLPTALLG 378
Cdd:cd17324 239 LLLLFGVAGVVGSPLAGRLADRGG-RRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP 317
|
....*..
gi 1147533804 379 GMSAAAG 385
Cdd:cd17324 318 EARGLAS 324
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
63-353 |
3.28e-11 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 64.15 E-value: 3.28e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 63 DLHFSETVYGMGAGIFFLGYFLFEVPSNLILHRVGARRWLARIMLTWAVISASFVFVKSPTAFYVLRFALGVAEAGFAPG 142
Cdd:cd17489 25 DLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 143 VILYLTYWFPSARRAKALSLFFMAIPLAGIIGGPLSGAIMHSLHGAMSMagwkWLFLLEALPSFVLGFAIllylddgiag 222
Cdd:cd17489 105 AATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLF----IVAAVLALLALLLVFLV---------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 223 akwltdaeKALLARNVSADAAHTTAHLSIRtfvaDRRLWLMAAIYFCVVLGQYGLTFWLPTIIRKAGVADPlwvGLFTAI 302
Cdd:cd17489 171 --------KDPPPVAAEEAEAGTRAFRRLV----EKKVLPPALILFLASIAYGAISTFLPLYAAERGISNA---GLFFTV 235
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1147533804 303 PYACAIVALPLIGISADRRRERRFhLAVPMLVAAAGFATLPMLGSVAASIV 353
Cdd:cd17489 236 YAIALLLSRPFSGKLSDRKGPKTV-IIPGLLLLALGLLLLSFAGSPWMLLL 285
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
59-362 |
1.25e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 62.56 E-value: 1.25e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 59 QMLNDLHFSETVYGMGAGIFFLGYFLFEVPSNLILHRVGARRWLARIMLTWAVISASFVFVKSPTAFYVLRFALGVAEAG 138
Cdd:COG0738 33 ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 139 FAPGVILYLTYWFPsARRAKALSLFFMAIPLAGIIGGPLSGAIMHSLHGAmsmaGWKWLFLLEALPSFVLGFAILLyldd 218
Cdd:COG0738 113 LDVAANPYVAALGP-ETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSL----SWHLPYLILAVLLLLLALLFLR---- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 219 giagakwltdaekALLARNVSADAAHTTAHLSIRTFVADRRLWLMAAIYFCVVLGQYGLTFWLPTIIRKAGVADPLWVGL 298
Cdd:COG0738 184 -------------SKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAAL 250
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1147533804 299 FTAIPYACAIVALPLIGISADRRRERRFhLAVPMLVAAAGFATLPMLGSVAASIVCLSIASAGI 362
Cdd:COG0738 251 GLSLFWGGMTIGRFLGGFLLKRFGPVRL-LRLSALLAAVGLLLALLAPGPWLALIGLALVGLGL 313
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
33-318 |
9.20e-10 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 59.05 E-value: 9.20e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 33 RRLIPFLMLCYLGAYLDRVNVGFAKLQMLNDLHFSETVYGMGAGIFFLGYFLFEVPSNLILHRVGARRWLARIMLTWAVI 112
Cdd:COG0477 13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 113 SASFVFVKSPTAFYVLRFALGVAEAGFAPGVILYLTYWFPSARRAKALSLFFMAIPLAGIIGGPLSGAIMHSLhgamsma 192
Cdd:COG0477 93 SLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAAL------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 193 GWKWLFLLEALPSFVLGFAILLYLDDGIAGAKWLTDAEKALLARNVSADAAHTTAHLSIRTFVADRRLWLMAAIYFCVVL 272
Cdd:COG0477 166 GWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLAL 245
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1147533804 273 GQYGLTFWLPTIIRKAGVADPLWVGLFTAIPYACAIVALPLIGISA 318
Cdd:COG0477 246 LLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLL 291
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
58-369 |
1.73e-09 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 58.80 E-value: 1.73e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 58 LQMLNDLHFSETVYGMGAGIFFLGYFLFEVPSNLILHRVGARRW-LARIMLTWAVISASFVFVKSPTAFYVLRFALGVAE 136
Cdd:cd17341 23 PVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVfIASLLLLLIPLLALALAVSSYWGLLVLGFLLGFAG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 137 AGFAPGvILYLTYWFPSARRAKALSLFFMaiplAGIIGGPLSG----AIMHSLHGAMSMAGWKWLFLLEALPSFVLGFAI 212
Cdd:cd17341 103 ANFASG-QPWASFWFPKEKIGGAAGGIAG----AGNMGVAVSQllapLIAGAIVFDGGFVGWRNAFFVPGILLAIAAVLV 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 213 LLYLDDGIAGAKWLTDAEKALLARnvsadaahttahlsirtfVADRRLWLMAAIYFCVVLGQYGLTFWLPTIIRKAGVAD 292
Cdd:cd17341 178 LLFGDDLPTGKASALEFLKVQLAV------------------LKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLP 239
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1147533804 293 PLWVGLFTAIPYACAIVALPLIGISADRRRERRFHLAVPMLVAAAGFAtLPMLGSVAASIVCLSIASAGILASSSQF 369
Cdd:cd17341 240 LVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAAL-LSLSLPTSGTNLVLFLALFVALGLGAGA 315
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
95-376 |
1.97e-09 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 58.38 E-value: 1.97e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 95 RVGARRWLARIMLTWAVISASFVFVKSPTAFYVLRFALGVAEAGFAPGVILYLTYWFPSARRAKALSLFFMAIPLAGIIG 174
Cdd:cd17316 62 RIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLA 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 175 GPLSGAIMHSLHGAmsmAGWKWLFLLEALPSFVlgfaillylddgiagakwltdaekALLARnvsadaahttahlsirtf 254
Cdd:cd17316 142 ALVASLLIPLLSGD---WGWRILFLIGALPALL------------------------ALLLR------------------ 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 255 vadRRLWLMAAIYFCVVLGQYGLTFWLPTIIRKAGVADPLWVGLFTAIPYACAIVALPLIGISADrRRERRFHLAVPMLV 334
Cdd:cd17316 177 ---RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSD-RIGRKKTLVIGLIL 252
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 1147533804 335 AAAGFATLPML--GSVAASIVCLSIASAGILASSSQFWSLPTAL 376
Cdd:cd17316 253 SGILALPLFYLlsGSPTLLLLLLFILSFFVGGVWGALYAYLAEL 296
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
84-361 |
2.84e-09 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 58.35 E-value: 2.84e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 84 LFEVPSNLILHRVGARRWLARIMLTWAVISASFVFVKSPTAFYVLRFALGVAEAGFAPGVILYLTYWFPSARRAKALSLF 163
Cdd:cd17473 50 LFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQ 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 164 FMAIPLAGIIGGPLSGAImhslhgamSMAGWKWLFLLEALPSFVLGFAILlylddgiagakwltdaekaLLARNVSADAA 243
Cdd:cd17473 130 SAAMSLGGVVFLLLGGAL--------AEIGWRAPFLVYLLALPVLILVLL-------------------FLPEPARKSKS 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 244 HTTAHLSIRTFVADRRLWLMAAIYFCVVLGQYGLTFWLPTIIRKAGVADPLWVGLFTAIpyacAIVALPLIGISADRRRE 323
Cdd:cd17473 183 AASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAI----ASLAGAIGALLFGRLKR 258
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 1147533804 324 RRFH---LAVPMLVAAAGFATLPMLGSVAASIVCLSIASAG 361
Cdd:cd17473 259 RLGKrrlLAIGFALMALGFLLLALASGLWVVLLGAILAGLG 299
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
41-384 |
6.93e-08 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 53.82 E-value: 6.93e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 41 LCYLGAYLDRVNVGFAKLQMLNDLHFSETVYGMGAGIFFLGYFLFEVPSNLILHRVGARRWLARIMLTWAVISASFVFVK 120
Cdd:cd17312 10 LGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFST 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 121 SPTAFYVLRFALGVAE-AGFAPGVILyLTYWFPSARRAKALSLFFMAIPLAGIIGGPLSGAIMHSLhgamsmaGWKWLFL 199
Cdd:cd17312 90 SLWFFAVLWGLNGLFQsMGWPPCVKL-LGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYY-------GWRAAFL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 200 LEALPSFVLGFAILLYLDDgiagakwltdaekallarnvsadaahttahlsirtfvADRRLWLMAAIYFCVVLGQYGLTF 279
Cdd:cd17312 162 VPGIVGLVVAIILFFFLRD-------------------------------------SPPYVWVLSLAYAFVYIVRYACLD 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 280 WLPTIIRKAGVADPLWVGLFTAIPYACAIVALPLIGISADRRRERRFHLA-----VPMLVAAAGFatLPMLGSVAASIVC 354
Cdd:cd17312 205 WGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGRRAPIaviymLLMTLSLALF--WFFPHNKLLSIVL 282
|
330 340 350
....*....|....*....|....*....|
gi 1147533804 355 LSIASAGILASSSQFWSLPTALLGGMSAAA 384
Cdd:cd17312 283 LFLIGFFVGGPINLIGGAAAQDIGRKEAAG 312
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
53-286 |
1.31e-07 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 53.50 E-value: 1.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 53 VGFAKLQMLNDLHFSETVYGMGAGIFFLGYFLFEVPSNLILHRVGARRWLARIMLTWAVISASFVFVKSPTAFYVLRFAL 132
Cdd:cd17439 18 VGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLS 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 133 GVAEAGFAPGVILYLTYWFPSARRAKALSLFFMAIPLAGIIGGPLSGAIM------HSLHGAMSMAGWKWLFLLEALPSf 206
Cdd:cd17439 98 GVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYASAMAWAIIphygwsFQMGSAYQFHSWRVFVLVCAFPS- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 207 VLGFAIL--------LYLDDGIAGAKWLTdaEKALLARNVSADAaHTTAHLSIrTFVADRRLWLMAAIYFCVVLGQYGLT 278
Cdd:cd17439 177 VFAIGALttmpesprFFLENGKHDEAWMV--LKQVHDTNMRAKG-HPERVFSV-THIKRRITLMMMAVWFTMSFSYYGLT 252
|
....*...
gi 1147533804 279 FWLPTIIR 286
Cdd:cd17439 253 VWFPDMIK 260
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
66-368 |
1.86e-07 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 52.74 E-value: 1.86e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 66 FSETVYGMGAGIFFLGYFLfevpsnlilHRVGARRWLARIMLTWAVISASFVFVKSPTAFYVLRFALGVAEAGFAPGVIL 145
Cdd:TIGR00895 58 FSAGLIGMAFGALFFGPLA---------DRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNA 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 146 YLTYWFPSARRAKALSLFFMAIPLAGIIGGPLSGAIM--HSLHGAMSMAGWKWLFLLEALPSFVLGFAILLYLDDGIAGA 223
Cdd:TIGR00895 129 LVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIpvFGWRSLFYVGGIAPLLLLLLLMRFLPESIDFLVSKRPETVR 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 224 KWLTDAEKALLARNVSA----DAAHTTAHLSIRTFVADRR------LWLMaaiYFCVVLGQYGLTFWLPTIIRKAGvADP 293
Cdd:TIGR00895 209 RIVNAIAPQMQAEAQSAlpeqKSTQGTKRSVFKALFQGKTaritvlLWLL---YFMLLVGVYFLTNWLPKLMVELG-FSL 284
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1147533804 294 LWVGLFTAIPYACAIVALPLIGISADRRReRRFHLAVPMLVAAAGFATLPMLGSVaaSIVCLSIASAGILASSSQ 368
Cdd:TIGR00895 285 SLAATGGALFNFGGVIGSIIFGWLADRLG-PRVTALLLLLGAVFAVLVGSTLFSP--TLLLLLGAIAGFFVNGGQ 356
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
59-362 |
1.03e-06 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 50.26 E-value: 1.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 59 QMLNDLHFSETVYGMGAGIFFLGYFLFEVPSNLILHRVGARRWLARIMLTWAVISASFVFVKSPTAFYVLRFALGVAEAG 138
Cdd:cd17474 24 AIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 139 FAPGVILYLTYWFPSARRAKALSLFFMAIPLaGIIGGPLSGaimhslhGAMSMAGWKWLFLLEALPSFVLGFAILLYLDD 218
Cdd:cd17474 104 LGPLALTLIGDLFEGGERAKAMGLYEAALGL-GIAVGPLLG-------GLLAAISWRYPFFLLAALIPVAFLAILFLLPE 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 219 GIAGAKWLTdaekallarnvsadaahTTAHLSIRTFVADRRLWLMAAIYFCVVLGQYGLTFWLPTIIRKAGVADPLWVGL 298
Cdd:cd17474 176 PKEKAKSSS-----------------ATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGL 238
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1147533804 299 FTAIPYACAIVALPLIGISADRRRERRFHLAVPMLVAAAGFATLPMLGSVAASIVCLSIASAGI 362
Cdd:cd17474 239 LFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGL 302
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
39-369 |
1.64e-06 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 49.54 E-value: 1.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 39 LMLCYLGAYLDRVNVGFAKLQMLN----------------------DLHFSETVYGMGAGIFFLGYFLFEVPSNLILHRV 96
Cdd:cd17318 4 LFLGFAVVYAMRVNLSVAIVAMVNstathdnnntstdkdtlpveapEFDWSEKTQGIILSSFFYGYILTQIPGGYLAEKY 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 97 GARRwlariMLTWAVISASFVFVKSP-------TAFYVLRFALGVAEAGFAPGVILYLTYWFPSARRAKALSLFFMAIPL 169
Cdd:cd17318 84 GAKR-----VLGYSILITALLTLLTPlaarggyGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 170 AGIIGGPLSGAIMHSLhgamsmaGWKWLFllealpsfvlgfaillYLdDGIAGAKWltdaekallarnvsadaahttahl 249
Cdd:cd17318 159 GTVIAMPLSGFLCESL-------GWPSIF----------------YI-FGGLGLLW------------------------ 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 250 SIRTFVADRRLWLMAAIYFCVVLGQYGLTFWLPTIIRKAGVADPLWVGLFTAIPYACAIVALPLIGISAD--RRRERRFH 327
Cdd:cd17318 191 CLLWFFLVLPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADwlRSRGILST 270
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1147533804 328 LAVPMLVAAAGFaTLPMLGSVAA---------SIVCLSIASAGILASSSQF 369
Cdd:cd17318 271 TTVRKLFTSIGF-LGPGVFLIALgylgsnatlAVVFLTLSVGLSGACYSGF 320
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
59-386 |
2.97e-06 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 48.84 E-value: 2.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 59 QMLNDLHFSETVYGMGAGIFFLGYFLFEVPSNLILHRVGARRWLARIMLTWAVISASFVFVKSPTAFYVLRFALGVAEA- 137
Cdd:cd06180 24 LMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAf 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 138 GFAPGVILYLtYWFPSARRAKALSLFFmAIPLAGIIGGPLSGAIMHSLHGamsmaGWKWLFLLEALPSFVLGFAILLYLD 217
Cdd:cd06180 104 VFVFGSNLVL-HHATAAGRGHLIGLLF-AGVGLGIALSGLLVPAGLGGGL-----SWRAGWLALALLSAVLLLLSFLLLR 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 218 DGIagakwltdaekallarnvsadAAHTTAHLSIRTFVADRRLWLMAAIYFCVVLGQYGLTFWLPTIIRKAGvADPLWVG 297
Cdd:cd06180 177 RGP---------------------SAPTEASAAESAPGLNRPLWRLALAYGLFGFGYIITATFLPLIARETG-AGSLLAG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 298 LFTAIPYACAIVALPLIGISADRRRERRFhLAVPMLVAAAGFATLPMLGSVAASIVC--------LSIASAGILASSSQF 369
Cdd:cd06180 235 LLWSLFGLAAVPSCFLWGALSDRWGTRRA-LAANLLVQAVGVLLPLLSPGPAGLVLSavlfggtfMAITALVMALARELA 313
|
330
....*....|....*..
gi 1147533804 370 WSLPTALLGGMSAAAGI 386
Cdd:cd06180 314 PPAAPRALALMTASFGV 330
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
60-345 |
3.19e-06 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 48.77 E-value: 3.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 60 MLNDLHFSETVYGMGAGIFFLGYFLFEVPSNLILHRVGARRWLARIMLTWAVISASFVFVKSPTAFYVLRFALGVAEAGF 139
Cdd:cd17475 22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 140 APGVILYLTYWFPSARRAKALSLFFMAIPLAGIIGGPLSGAIMHSlhgamsmAGWKWLFLLEALPSFVLGFAILLYLDDG 219
Cdd:cd17475 102 QPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALH-------YGWRAAFVVAGLVSILAAVLFWLFYREP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 220 IAGAkwlTDAEKAllarnvsadaahTTAHLSIRTFVADRRLWLMAAIYFCVVLGQYG-LTFWLPTIIRKAGVAdPLWVGL 298
Cdd:cd17475 175 PAAS---AATESA------------STLLRSLKEVLRNRDVWLIAIAGALLVAPQFAlLTFLLLFLHDHLGLS-VVAAGA 238
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 1147533804 299 FTAIPYACAIVALPLIGISADR--RRERRFHLAVPMLVAAAGFATLPML 345
Cdd:cd17475 239 LLAVAQLGGALGRIGLGRVSDRvfGGRRRPVLVITAAIAAAALLVLSLL 287
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
60-351 |
4.04e-06 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 48.42 E-value: 4.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 60 MLNDLHFSETVYGMGAGIFFLGYFLFEVPSNLILHRVGARRWLARIMLTWAVISASFVFVKSPTAFYVLRFALGVAEAG- 138
Cdd:cd17355 29 IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGt 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 139 FAPGVILYLTYWFPSARRAKALSLFFMAIPLAGIIGGPLSGAIMHSLhgamsmaGWKWLFLLEALPSFVLGFAILLYLDD 218
Cdd:cd17355 109 LAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAF-------GWRTALLVLALLALLVLVPVLLLLRR 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 219 giagakwltdaEKALLARNVSADAAHTTAHLSIRTFVADRRLWLMAAIYFCVVLGQYGLTFWLPTIIRKAGVADPLWVGL 298
Cdd:cd17355 182 -----------RPADLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVA 250
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1147533804 299 FTAIpYACAIVALPLIGISADrRRERRFHLAVPMLVAAAGFATLPMLGSVAAS 351
Cdd:cd17355 251 LALI-GLFNIVGRLLSGWLGD-RYSPRRLLAASYALRALGLALLLLLPFPPLA 301
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
95-341 |
6.82e-06 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 47.68 E-value: 6.82e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 95 RVGARRWLARIMLTWAVISASFVFVKSPTAFYVLRFALGVAEAG-FAPGVILYLTYWfPSARRAKALSLFFMAIPLAGII 173
Cdd:cd17371 60 RFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGeWAAGAALMAEYV-PARHRGKALGYVQSGWAVGWLL 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 174 GGPLSGAIMHSLHGAMsmaGWKWLFLLEALPSFVLGFAillylddgiagAKWLTDAEKALLARnvsADAAHTTAHLSIRT 253
Cdd:cd17371 139 ATLLAALLFPLLPPEI---AWRVLFLLGALPALLVLFI-----------RRFVKEPPQWQAAR---AARRHFADRPSLRE 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 254 FVAD--RRLWLMAAIYFCVVL-GQYGLTFWLPTIIRKAGVADPLWVGLFTAIPYACAIVALPLIGISADrRRERRFHLAV 330
Cdd:cd17371 202 LFSPplLRTTLLASLLATGALgGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLAD-RIGRRNNFAL 280
|
250
....*....|.
gi 1147533804 331 PMLVAAAGFAT 341
Cdd:cd17371 281 FALGSAISILL 291
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
61-347 |
9.15e-06 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 47.22 E-value: 9.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 61 LNDLHFSETVYGMGAGIFFLGYFLFEVPSNLILHRVGARRWLARIMLTWAVISASFVF-VKSPTAFYVLRFALGVAEAGF 139
Cdd:cd17490 23 AESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIGLLFTVLASLIMIlFPSPWGLLIARFLSGIAAATW 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 140 APGVILYLTYwFPSARRAKALSLFFMAIPLAGIIGGPLSGAIMHSLhgamsmaGWKWLFLLEALPSfVLGFAILLYLDdg 219
Cdd:cd17490 103 VSFTVLYASY-FPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHF-------GMRAPFLLAALAG-VLGFILSLFIK-- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 220 iagakwltdaEKALLARNVSadaahtTAHLSIRTFVADRRLWLMAAIYFCVVLGQYGLTFWLPTIIRKAGVADPLWVGLF 299
Cdd:cd17490 172 ----------EERREKKPVL------TELKELLSVLKDKKLLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLL 235
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 1147533804 300 TAIPYACAIVALPLIGISADRRRERRFHLAVPMLVAAAGFATLPMLGS 347
Cdd:cd17490 236 SIIYLLPNALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPN 283
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
121-352 |
1.55e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 46.40 E-value: 1.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 121 SPTAFYVLRFALGVAEAGFAPGVILYLTYWFPSARRAKALSLFFMAIPLAGIIGGPLSGAIMHSLhgamsmaGWKWLFLL 200
Cdd:cd17321 83 SLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELF-------GWRWIFLI 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 201 EALPSFVLgfaillylddgiagakwltdaekallarnvsadaahttahlsirtFVADRRLWLMAAIYFCVVLGQYGLTFW 280
Cdd:cd17321 156 NVPIGLVA---------------------------------------------LLLARTFSGAVLAAFLLGAALGGLLFL 190
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1147533804 281 LPTIIRKAGVADPLWVGLFTAIPYACAIVALPLIGISADRRRERRFhLAVPMLVAAAGFATLPMLGSVAASI 352
Cdd:cd17321 191 LPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLV-LVAGLLLTAVGLLLLALLGADSSVW 261
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
63-365 |
1.78e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.45 E-value: 1.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 63 DLHFSETVYGMGAGIFFLGYFLFEVPSNLILHRVGARRWLARIMLTWAVISASFVFV-----KSPTAFYVLRFALGVAEA 137
Cdd:cd06173 28 QLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLallgsLSLWLLLVLAFLLGIASA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 138 GFAPGVILYLTYWFPSARRAKALSLFFMAIPLAGIIGGPLSGAIMHSLhgamsmaGWKWLFLLEALpSFVLGFAILLYLd 217
Cdd:cd06173 108 FFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALL-------GPGGAFAINAL-SFLLSALLLLFI- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 218 dgiagakwltdAEKALLARNVSADAAHTTAHLSIRTFVADRRLWLMAAIYFCVVLGQYGLTFWLPTIIRKAGVADPLWVG 297
Cdd:cd06173 179 -----------RRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYG 247
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1147533804 298 LFTAIPYACAIVALPLIGISADRRRERRFhLAVPMLVAAAGFATLPMLGSVAASIVCLSIASAGILAS 365
Cdd:cd06173 248 LLLAAFGVGALLGALLLGRLSKRRRRGRL-LLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLF 314
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
53-286 |
2.13e-05 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 46.45 E-value: 2.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 53 VGFAKLQMLNDLHFSETVYGMGAGIFFLGYFLFEVPSNLILHRVGARRWLARIMLTWAVISASFVFVKSPTAFYVLRFAL 132
Cdd:cd17438 18 VGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLFCRLIS 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 133 GVAEAGFAPGVILYLTYWFPSARRAKALSLFFMAIPLAGIIGGPLSGAIMHSLHGAMSMA------GWKWLFLLEALPSF 206
Cdd:cd17438 98 GFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYASAMAWSIIPHYGWGFSMGtnyhfhSWRVFVIICALPCI 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 207 VLGFAI-------LLYLDDGIAGAKW--LTDAEKALLARNVSADAAHTTAHLSIRTFVadrrlwLMAAIYFCVVLGQYGL 277
Cdd:cd17438 178 ASIIALkfmpespRFLLEMGKHDEAWmiLKNIHDTNMRAKGTPEKVFTVSNIKRKNTL------FLAVVWFTMAFSYYGL 251
|
....*....
gi 1147533804 278 TFWLPTIIR 286
Cdd:cd17438 252 TVWFPDMIR 260
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
60-216 |
3.92e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 45.26 E-value: 3.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 60 MLNDLHFSETVYGMGAGIFFLGYFLFEVPSNLILHRVGARRWLARIMLTWAVISASFVFVKSPTAFYVLRFALGVAEAGF 139
Cdd:cd17325 226 AAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLV 305
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1147533804 140 APGVILYLTYWFPSARRAKALSLFFMAIPLAGIIGGPLSGAIMHSLhgamsmaGWKWLFLLEALPSFVLGFAILLYL 216
Cdd:cd17325 306 FPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAF-------GFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
95-386 |
4.66e-05 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 44.88 E-value: 4.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 95 RVGARRWLARIMLTWAVISASFVFVKSPTAFYVLRFALGVAEAGFAPGVILYLTYWFPSARRAKALSLFFMAIPLAGIIG 174
Cdd:cd17365 60 RFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALG 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 175 GPLSGAIMHSLhgamsmaGWKWLFLLEALPSFVLgfaillylddgiagakwltdaekallarnvsadaahttahlsirtF 254
Cdd:cd17365 140 GFLAAALIPAF-------GWRSVFLLGGVPPLIL---------------------------------------------L 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 255 VADRRLWLMAAIYFCVVLGQYGLTFWLPTIIRKAGvADPLWVGLFTAIPYACAIVALPLIGISADRRRERRFhLAVPMLV 334
Cdd:cd17365 168 PLLRGTLLLWVTFFMGLLLVYLLNSWLPKLMVEAG-YSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRV-LALFFAL 245
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1147533804 335 AAAGFATLP--------MLGSVAASIVCLSIASAGILASSSQFWslPTALLG-GMSAAAGI 386
Cdd:cd17365 246 GAVSLALLGvspaslvlLYVLVFLAGACVNGAQVGLYALAARFY--PTEVRAtGVGWALGV 304
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
63-353 |
4.91e-05 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 44.99 E-value: 4.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 63 DLHFSETVYGMGAGIFFLGYFLFEVPSNLILHRVGARRWLARIMLTWAVISASFVFV-KSPTAFYVLRFALGVAEAGFAP 141
Cdd:TIGR00886 31 DLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAvQSYSVLLLIRLFIGIAGGSFAS 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 142 GvILYLTYWFPSARRAKALSLFF----MAIPLAGIIGGPLSGAIMhSLHGAMSMAGWKWLFLL-EALPSFVLGFAILLYL 216
Cdd:TIGR00886 111 C-MPWISFFFPKKIQGTALGLAAgwgnMGGGVAQFVMPPIIGSLI-FGGGQPAHLAWGWAFVIvPAGILLLPALLIFFVG 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 217 DDGIAGAKwltdaekallarnvsadaahTTAHLSIRTFVA---DRRLWLMAAIYFCVVLGQYGLTFWLPTIIRKAGVADP 293
Cdd:TIGR00886 189 ADTPPGKP--------------------ATGKLSFKEALKvfgNRHTWILALLYSVTFGSFLGVSSIFAMLFKDQFGLSK 248
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1147533804 294 LWVGLFTAIPYACAIVALPLIGISADRRRERRFHLAVPMLVAAAGFA---TLPMLGSVAASIV 353
Cdd:TIGR00886 249 VQAGAYASLGGFLGSLARPAGGAISDRLGGARKLLMNFLGVAMGAFLvvlGLVSDGSLAAFIV 311
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
156-380 |
1.15e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 44.12 E-value: 1.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 156 RAKALSLFFMAIPLAGIIGGPLSGAIMHSLhGAMSMAGWKWLFLLEALPSFVLGFAILLYLDDgiagakwltdaekalla 235
Cdd:COG2211 145 RTRLSSWRFAFAGLGGLLASVLPPPLVAAF-GGDAALGYRLTALIFAVLGLLAFLLTFFGTKE----------------- 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 236 rNVSADAAHTTAHLSIRTFVADRRLWLMAAIYFCVVLGQYGLTFWLPTIIRKAGVADPLWVGLFTAIPYACAIVALPLIG 315
Cdd:COG2211 207 -RPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWP 285
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1147533804 316 ISADRRRERRFHLAVpMLVAAAGFATLPMLGSVAASIVCLSIASAGILASSsqFWSLPTALLGGM 380
Cdd:COG2211 286 RLAKRFGKKKAFIIG-LLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGA--ILVLPWAMLADV 347
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
55-361 |
2.04e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 42.98 E-value: 2.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 55 FAKLQMLNDLHFSETVYGMGAGIFFLGYFLFEVPSNLILHRVGARRWLARIMLTWAVISASFVFVKSPTAFYVLRFALGV 134
Cdd:cd17329 21 FMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGF 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 135 AEAGFAPGVILYLTYWFPSARRAKALSLFFMAIPLAGIIGGPLSgaimhslhGAMSMAGWKWLFLLEALpSFVLGFAILL 214
Cdd:cd17329 101 GGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLG--------GLLLLYSFRLLFLAAAV-LFLLAALVLL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 215 ylddgiagakWLTDAEKALLARNVSADAAhttahLSIRTFVADRRLWLMAAIYFCVVLGQYGLTFWLPTIIRKAGVADPL 294
Cdd:cd17329 172 ----------FLLPETRPKRRAAEKTEIL-----RGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGES 236
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1147533804 295 WVGLFTAIPyACAIVALPLIGISADRRRERRFHLAVPMLVAAAGFATLPMLGSVAASIVCLSIASAG 361
Cdd:cd17329 237 LLGLLLALN-ALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLG 302
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
41-218 |
2.27e-04 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 43.00 E-value: 2.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 41 LCYLGAYLDRVNVGFAKLQMLNDLHFSETVYGMGAGIFFLGYFLFEVPSNLILHRVGARRWLARIMLTWAVISASFVFVK 120
Cdd:cd17345 10 IGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVP 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 121 SPTA----FYVLRFALGVAE-AGFAPGVILyLTYWFPSARRAKALSLFFMAIPLAGIIGGPLSGAIMhslhGAMSMAGWK 195
Cdd:cd17345 90 SATSsvglMFILLFLNGWFQgMGWPPSGRT-MVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGL----AIFGDGWWR 164
|
170 180
....*....|....*....|...
gi 1147533804 196 WLFLLEALPSFVLGFAILLYLDD 218
Cdd:cd17345 165 GAFIFPAIIAIIVAVIVLFLGKD 187
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
61-182 |
3.11e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 42.55 E-value: 3.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 61 LNDLHFSETVYGMGAGIFFLGYFLFEVPSNLILHRVGARRWLARIMLTWAVISASFVFVKSPTAFYVLRFALGVAEAGFA 140
Cdd:cd17477 23 LEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLF 102
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1147533804 141 PGVILYLTYWFPSARRAKALSLFFMAIpLAGIIGGPLSGAIM 182
Cdd:cd17477 103 VVSESWLNALATNENRGRVLGLYSTVL-GLGFALGPLLLALV 143
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
68-321 |
2.23e-03 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 39.94 E-value: 2.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 68 ETVYGMGAGIFFLGYFLFEVPSNLILHRVGaRRWLARIMLTWAVISASFVFV----KSPTAFYVLRFALGVAEAGFAPGV 143
Cdd:cd17357 48 DLLWSLIVSIFFIGGAIGSFISAFLANRFG-RKNGLLISNALLVVSSLLMFLsksaKSPELLIFGRFLVGIACGLSTGFV 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 144 ILYLTYWFPSARRAKALSLFFMAIPLAGIIGGPLSgaiMHSLHGamSMAGWKWLFLLEALPSfVLGFAILLYLDDgiaGA 223
Cdd:cd17357 127 PMYLQEISPSELRGALGSLTQIGVTLGILLGQVFG---LPSVLG--TETLWPYLLFFPGIPA-LLQLAALPFFPE---SP 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 224 KWL-------TDAEKAL-LARNVSADAAHTTAHL-------------SIRTFVADRRLWLMAAIYFCVVLGQ-----YGL 277
Cdd:cd17357 198 KFLliskgdeEEAEKSLkFLRGIEDDVDQELEEIkkeseqmgdqkqvSLMQLLRDPSLRLPLLLVLVVSASQqfsgiNAI 277
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1147533804 278 TFWLPTIIRKAGV--ADPLWVGLFTAIPYACAIVALPLIGISADRR 321
Cdd:cd17357 278 FFYSTFIFENAGFspQLAEWANLGIGIVNVLSTIVGPFLIEKVGRR 323
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
53-181 |
2.34e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 39.72 E-value: 2.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 53 VGFAKLQMLNDLHFSETVYGMGAGIFFLGYFLFEVPSNLILHRVGARRWLARI-MLTWAVISASFVFVKSPTAFYVLRFA 131
Cdd:cd06174 223 STLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIgLLLMALGLALLLLAPSLLLLLLLLLL 302
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 1147533804 132 LGVAEAGFAPGVILYLTYWFPSARRAKALSLFFMAIPLAGIIGGPLSGAI 181
Cdd:cd06174 303 LGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFL 352
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
76-216 |
2.43e-03 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 38.01 E-value: 2.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 76 GIFFLGY----FLFEVPSNLILHRVGARRWLARIMLTWAVISASFVFVKSPTAFYVLRFALGVAEAGFAPGVILYLTYWF 151
Cdd:TIGR00880 1 GLLLAGYalgqLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1147533804 152 PSARRAKALSLFFMAIpLAGIIGGPLSGAIMhslhgaMSMAGWKWLFLLEALPSFVLGFAILLYL 216
Cdd:TIGR00880 81 PPEERGVALGLMSAGI-ALGPLLGPPLGGVL------AQFLGWRAPFLFLAILALAAFILLAFLL 138
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
78-387 |
2.59e-03 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 39.73 E-value: 2.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 78 FFLGYFLFEVPSNLILHRVGARRWLARIMLTWAVISasFVFVKSPTAFYVLRFAL----GVAEAGFAPGVILYLTYWFPS 153
Cdd:TIGR00894 85 HFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVIS--IVIPWAAGGGIALVVFCrviqGLAQGSVSPATHKIIVKWAPP 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 154 ARRAKALSLFFMAIPLAGIIGGPLSGAImhslhgAMSMAGWKWLFLLEALPSFVLGFAILLYLDDGIAGAKWLTDAEKAL 233
Cdd:TIGR00894 163 KERSRLLGMSTSGFQLGTFIFLPISGWL------CESWGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKY 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 234 LARNVSADAAHTTAHLSIRTFVADRRLWLMAAIYFCVVLGQYGLTFWLPTIIRKAGVADPLWVGLFTAIPYACAIVALPL 313
Cdd:TIGR00894 237 INSSLQGQKGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIF 316
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1147533804 314 IGISADrrrerrFHLAVPMLVAAAG---FATLPMLGsVAASIVCLSIASAGIlASSSQFWSLPTALLGGMSAAAGIA 387
Cdd:TIGR00894 317 AGYLAD------FLKSSKTLSLTAArkiFNGIGGLG-PGIFAYALPYLSAAF-YLTIIILTLANAVSSGPLAGVLIN 385
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
77-360 |
4.68e-03 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 38.84 E-value: 4.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 77 IFFLGYFLFEVPSNLILHRVGARRWLARIMLTWAVISASFVFVKSPTAFYVLRFALGVAEAGFAPGVILYLTYWFPSARR 156
Cdd:TIGR00898 135 CFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQR 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 157 AKALSLFFMAIPLaGIIGGPLSG-AIMHslhgamsmagWKWLFLLEALPSFVLGFAILLYlddgIAGAKWL------TDA 229
Cdd:TIGR00898 215 AIVGTLIQVFFSL-GLVLLPLVAyFIPD----------WRWLQLAVSLPTFLFFLLSWFV----PESPRWLisqgriEEA 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 230 EKALLA------RNVSADAAHTTA------HLSIRTFVADRRLWLMAA-------IYFCVVLGQYGLTFWLPtiirKAGV 290
Cdd:TIGR00898 280 LKILQRiakingKKLPAEVLSLSLekdlssSKKQYSFLDLFRTPNLRKttlclmmLWFTTAFSYYGLVLDLG----NLGG 355
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1147533804 291 ADPLWVGLFTAIPYACAIVALPLIgisadRRRERRFHLAVPMLVAAAGFATL----PMLGSVAASIVCLSIASA 360
Cdd:TIGR00898 356 NIYLDLFISGLVELPAKLITLLLI-----DRLGRRYTMAASLLLAGVALLLLlfvpVDLYFLRTALAVLGKFGI 424
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
33-171 |
6.43e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 38.42 E-value: 6.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 33 RRLIPFLMLCYLGAYLDRVNVGFAKLQMLNDLHFSETVYGMGAGIFFLGYFLFEVPSNLILHRVGARRWLARIMLTWAVI 112
Cdd:COG2814 207 PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALG 286
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1147533804 113 SASFVFVKSPTAFYVLRFALGVAEAGFAPGVILYLTYWFPSARRAKALSLFFMAIPLAG 171
Cdd:COG2814 287 LLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
95-214 |
7.19e-03 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 38.27 E-value: 7.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 95 RVGARRWLARIMLTWAVISASFVFVKSPTAFYVLRFALGVAEAGFAPGVILYLTYWFPSARRAKALSLFFMAIPLAGIIG 174
Cdd:PRK15403 77 RIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIG 156
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1147533804 175 gPLSGA-IMHSLHgamsmagWKWLFLLEALPSFVLGFAILL 214
Cdd:PRK15403 157 -PLSGAaLMHFVH-------WKVLFAIIAVMGLIAFVGLLL 189
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
59-216 |
7.89e-03 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 37.94 E-value: 7.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 59 QMLNDLHFSETVYGMGAGIFFLGYFLfevpSNLI---LHRVGARRWLARIMLTWAVI-SASFVFVKSPTAFYVLRFALGV 134
Cdd:cd17323 24 QIAEDFHVSEEVANLGVSLFVLGFGL----GPLIwapLSELYGRRPVYLVSLFIFVIfQIGCALAPNIAMLIILRFLQGF 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1147533804 135 AEAGF---APGVILYLtywFPSARRAKALSLFFMAIPLAGIIGGPLSGAIMHSLhgamsmaGWKWLFLLEALPSFVLGFA 211
Cdd:cd17323 100 FGSSPlaiGAGTIADL---FTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSL-------GWRWIFWFLAIISGFCLIL 169
|
....*
gi 1147533804 212 ILLYL 216
Cdd:cd17323 170 IFLFL 174
|
|
| |
