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Conserved domains on  [gi|1092786850|ref|WP_070708204|]
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SusC/RagA family TonB-linked outer membrane protein [Porphyromonas sp. HMSC077F02]

Protein Classification

SusC/RagA family TonB-linked outer membrane protein( domain architecture ID 1000763)

SusC/RagA family TonB-linked outer membrane protein

Gene Ontology:  GO:0022857|GO:0009279

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OMP_RagA_SusC super family cl37378
TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade ...
 24-1003 0e+00

TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate]


The actual alignment was detected with superfamily member TIGR04056:

Pssm-ID: 274948 [Multi-domain]  Cd Length: 981  Bit Score: 681.62  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850   24 ITVKGIVTDERGDGVIGATVRLKsDATVGTMTGMDGDFTLKAKQGELIIVSYVGYKTQEVAAAP--NLNIKLVPDTELLD 101
Cdd:TIGR04056    1 ITVTGVVVDETGEPLIGASVVVK-GTTNGTITDIDGNFSLKVPPGAVLVFSYIGYKTQEVKVKGqkNLNITLKEDTQELD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  102 DVVVIGYGTRKVANTSASVVKINSKELQAKPTANIMDAVQGKVAGVKVLTSSGEPSERASINFHGKGSLGSDTTPLYILD 181
Cdd:TIGR04056   80 EVVVVGYGTQKKKSLTGAVSTVKAKELKKVPVSNLSNALQGKVAGVIITQSSGEPGGDAEIWIRGISSFGGNNSPLYVID 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  182 GVPVSDGlIQSLNPNDFESMQFLKDAAATSIYGARAANGVIYITTKRGVArERAQISVRTQYGIS------DLANPGYYK 255
Cdd:TIGR04056  160 GVPRDNG-LSDLNPEDIESISVLKDASATAIYGSRGANGVILITTKRGKE-GKPKISYNAEFGFStptrlpEMLNAYEYA 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  256 KLMNTNELFSFWEESGIKSKDEVADLRK---TYGNNNTEWWKY-YYQSAPSFQSDINVSGGAGRTNYYFSAGYLSQKGIR 331
Cdd:TIGR04056  238 ELYNEALLNRGSSPPDIYTDEEIEAYRNgldPDLYPNTDWQDEiFKRTAFNQRHNLSVSGGTEKARYYVSLGYYNEEGIL 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  332 AGSSYDKINMRLNLNSSLNDYIKMGINSSVSYDKARISPKSYASKETYVSLATLINPPYITPYKEDGSeYFDEPIPGLGA 411
Cdd:TIGR04056  318 KNSDYKRYNFRANIDAKLTKTLKLSLNVSGSLSKYNNPGGSTSNIWGALMLFPRGTPYSTPPVYSDGY-YPAYNSGNTSL 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  412 YNPkYHMTKDIPF-DKTLYMNVVGNITITPFKNFQLRSMVGVEVADY-TRDRLRLPSWKKLAG---NGTNSKQFSRDVLF 486
Cdd:TIGR04056  397 QNP-YALLNRGYNeNERNRLNGNASLEQKITKGLKLKGTFSYDYSNYkNKKYYKNPYYYNATGganNGYYSESNSRSRNY 475

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  487 STNNVAEYKFSVAdDHHFITLAGHEYINSKYNffsalGSGINDDRLTELQFATKDKTIESKTKEYAFLSFFGQFSYDYQE 566
Cdd:TIGR04056  476 YLEATLNYNRTFG-KHNVSALLGYSQQENKSS-----SYGGLLDDLPSLDAGTSDASVSGSDSEYRLQSLFGRATYSYKD 549

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  567 KYFLDLVLRNDASSRFSEKHRNAMFWSAGLLWKAKKEDFLANV-DWLNSLDFKASYGTQGNANIGNY----ESYATVGDG 641
Cdd:TIGR04056  550 RYLLEFNFRYDGSSRFAKGNRWGFFPSVSLGWRISEEKFMKKLkKWLSFLKLRASYGIVGNDNIGDRypylSLYNLGDGG 629

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  642 -----GKYMNNPGWKIAKAGNDELTWESQDKLTVGVAATLFD-RLSIDFEFYNRLTRNMLMDVPQPYTSGlklddmdFAS 715
Cdd:TIGR04056  630 ynfgtNNGTSVTGITESRYGNPNLKWEKTKKWNLGLDLGFFNnRLSLTVDYYYKKTKDILQSRSLPSVTG-------YSS 702

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  716 IKQNVGSYQNRGVDIKITGDIVRGKDYGVSGYFNFNYNADKIVKLFQGRDEWIlpGYGFGYVVGQPVNFMY-----PIFK 790
Cdd:TIGR04056  703 PYANIGKVKNKGVELSLNYRNKIGKDFSWSVRGNFTYNKNKILELDEGAYLPV--KYPYISKEGGPIGQIYgyiadGLFK 780

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  791 DID--------PKTGDPRWylpkldKDGNpikginnmNDNEVTSDfDESFLeqntGKHRYPPITGGFGFSANWRGLSLDA 862
Cdd:TIGR04056  781 DDDspkqtfgnVRPGDIKY------KDVN--------GDGKIDDD-DRVPI----GYSNTPDLTYGFGNSFSYKGFDLSA 841

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  863 DFAFVLGKWMIANETYFTKNPVAFAGMNTEKDSRNYWKQEGDNARYPSMKYQLATGTATKFDSSL-LSDASFMRLKNLTI 941
Cdd:TIGR04056  842 LFQGSGGGDVFNDGRGFYPFNGGDWGNVLKIVADNRWTPENPNADYPRLSYGDSNNSNNYQASTRwLEDGSYLRLKNLTL 921

                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1092786850  942 GYTFQKKLLEKQNvITGLKVYGTARNLLTFTKFEGIDPEVDSNLSFhTNPNTRQFVLGLEVS 1003
Cdd:TIGR04056  922 GYTLPKKWLKKIG-ISNLRVYFSGQNLFTFSKYKGWDPELQGNDGG-AYPLQRTFSFGVNLT 981
 
Name Accession Description Interval E-value
OMP_RagA_SusC TIGR04056
TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade ...
 24-1003 0e+00

TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 274948 [Multi-domain]  Cd Length: 981  Bit Score: 681.62  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850   24 ITVKGIVTDERGDGVIGATVRLKsDATVGTMTGMDGDFTLKAKQGELIIVSYVGYKTQEVAAAP--NLNIKLVPDTELLD 101
Cdd:TIGR04056    1 ITVTGVVVDETGEPLIGASVVVK-GTTNGTITDIDGNFSLKVPPGAVLVFSYIGYKTQEVKVKGqkNLNITLKEDTQELD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  102 DVVVIGYGTRKVANTSASVVKINSKELQAKPTANIMDAVQGKVAGVKVLTSSGEPSERASINFHGKGSLGSDTTPLYILD 181
Cdd:TIGR04056   80 EVVVVGYGTQKKKSLTGAVSTVKAKELKKVPVSNLSNALQGKVAGVIITQSSGEPGGDAEIWIRGISSFGGNNSPLYVID 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  182 GVPVSDGlIQSLNPNDFESMQFLKDAAATSIYGARAANGVIYITTKRGVArERAQISVRTQYGIS------DLANPGYYK 255
Cdd:TIGR04056  160 GVPRDNG-LSDLNPEDIESISVLKDASATAIYGSRGANGVILITTKRGKE-GKPKISYNAEFGFStptrlpEMLNAYEYA 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  256 KLMNTNELFSFWEESGIKSKDEVADLRK---TYGNNNTEWWKY-YYQSAPSFQSDINVSGGAGRTNYYFSAGYLSQKGIR 331
Cdd:TIGR04056  238 ELYNEALLNRGSSPPDIYTDEEIEAYRNgldPDLYPNTDWQDEiFKRTAFNQRHNLSVSGGTEKARYYVSLGYYNEEGIL 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  332 AGSSYDKINMRLNLNSSLNDYIKMGINSSVSYDKARISPKSYASKETYVSLATLINPPYITPYKEDGSeYFDEPIPGLGA 411
Cdd:TIGR04056  318 KNSDYKRYNFRANIDAKLTKTLKLSLNVSGSLSKYNNPGGSTSNIWGALMLFPRGTPYSTPPVYSDGY-YPAYNSGNTSL 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  412 YNPkYHMTKDIPF-DKTLYMNVVGNITITPFKNFQLRSMVGVEVADY-TRDRLRLPSWKKLAG---NGTNSKQFSRDVLF 486
Cdd:TIGR04056  397 QNP-YALLNRGYNeNERNRLNGNASLEQKITKGLKLKGTFSYDYSNYkNKKYYKNPYYYNATGganNGYYSESNSRSRNY 475

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  487 STNNVAEYKFSVAdDHHFITLAGHEYINSKYNffsalGSGINDDRLTELQFATKDKTIESKTKEYAFLSFFGQFSYDYQE 566
Cdd:TIGR04056  476 YLEATLNYNRTFG-KHNVSALLGYSQQENKSS-----SYGGLLDDLPSLDAGTSDASVSGSDSEYRLQSLFGRATYSYKD 549

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  567 KYFLDLVLRNDASSRFSEKHRNAMFWSAGLLWKAKKEDFLANV-DWLNSLDFKASYGTQGNANIGNY----ESYATVGDG 641
Cdd:TIGR04056  550 RYLLEFNFRYDGSSRFAKGNRWGFFPSVSLGWRISEEKFMKKLkKWLSFLKLRASYGIVGNDNIGDRypylSLYNLGDGG 629

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  642 -----GKYMNNPGWKIAKAGNDELTWESQDKLTVGVAATLFD-RLSIDFEFYNRLTRNMLMDVPQPYTSGlklddmdFAS 715
Cdd:TIGR04056  630 ynfgtNNGTSVTGITESRYGNPNLKWEKTKKWNLGLDLGFFNnRLSLTVDYYYKKTKDILQSRSLPSVTG-------YSS 702

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  716 IKQNVGSYQNRGVDIKITGDIVRGKDYGVSGYFNFNYNADKIVKLFQGRDEWIlpGYGFGYVVGQPVNFMY-----PIFK 790
Cdd:TIGR04056  703 PYANIGKVKNKGVELSLNYRNKIGKDFSWSVRGNFTYNKNKILELDEGAYLPV--KYPYISKEGGPIGQIYgyiadGLFK 780

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  791 DID--------PKTGDPRWylpkldKDGNpikginnmNDNEVTSDfDESFLeqntGKHRYPPITGGFGFSANWRGLSLDA 862
Cdd:TIGR04056  781 DDDspkqtfgnVRPGDIKY------KDVN--------GDGKIDDD-DRVPI----GYSNTPDLTYGFGNSFSYKGFDLSA 841

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  863 DFAFVLGKWMIANETYFTKNPVAFAGMNTEKDSRNYWKQEGDNARYPSMKYQLATGTATKFDSSL-LSDASFMRLKNLTI 941
Cdd:TIGR04056  842 LFQGSGGGDVFNDGRGFYPFNGGDWGNVLKIVADNRWTPENPNADYPRLSYGDSNNSNNYQASTRwLEDGSYLRLKNLTL 921

                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1092786850  942 GYTFQKKLLEKQNvITGLKVYGTARNLLTFTKFEGIDPEVDSNLSFhTNPNTRQFVLGLEVS 1003
Cdd:TIGR04056  922 GYTLPKKWLKKIG-ISNLRVYFSGQNLFTFSKYKGWDPELQGNDGG-AYPLQRTFSFGVNLT 981
CirA COG1629
Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];
100-753 2.27e-37

Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];


Pssm-ID: 441236 [Multi-domain]  Cd Length: 644  Bit Score: 149.98  E-value: 2.27e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  100 LDDVVVIGYGT-RKVANTSASVVKINSKELQAKPTANIMDAVQgKVAGVKVLTSSGEPSeraSINFHGKGSLGSDttPLY 178
Cdd:COG1629      1 LEEVVVTATRTdESLQDVPGSVSVISREQLEDQPATDLGDLLR-RVPGVSVTSAGGGAG---QISIRGFGGGGNR--VLV 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  179 ILDGVPVSDGL-----IQSLNPNDFESMQFLKDAAATsIYGARAANGVIYITTKRGVARERAQISVrtqygisdlanpgy 253
Cdd:COG1629     75 LVDGVPLNDPSggdggLSYIDPEDIERVEVLRGPSSA-LYGSGALGGVINIVTKKPKDGKGGEVSA-------------- 139

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  254 ykklmntnelfsfweesgikskdevadlrkTYGNNNTewwkyyyqsapsFQSDINVSGGAGRTNYYFSAGYLSQKGIRAG 333
Cdd:COG1629    140 ------------------------------SYGSYGT------------YRASLSLSGGNGKLAYRLSASYRDSDGYRDN 177

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  334 SSYDKINMRLNLNSSLNDYIKMGInsSVSYDKARispksyasketyvslatlinppyitpYKEDGSEYFDEPIPGLGAYN 413
Cdd:COG1629    178 SDSDRYNLRAKLGYQLGDDTRLTL--SASYSDSD--------------------------QDSPGYLTLAALRPRGAMDD 229

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  414 PKYHMTKDipFDKTLYMNVVGNITITPF-KNFQLRSMVGVEVADYTRDRLRLPSWkklAGNGTNSKQFSRDVLFSTNNVA 492
Cdd:COG1629    230 GTNPYSND--TDDNTRDRYSLSLEYEHLgDGLKLSASAYYRYDDTDLDSDFTPTP---ADGGTLEQTDFDNRTYGLELRL 304

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  493 EYKFSVADDHHFitLAGHEYINSKYN---FFSALGSGINDDRLTELQFATKDKTiesktkeyafLSFFGQFSYDYQEKYF 569
Cdd:COG1629    305 TYDLGFGGKHTL--LVGLDYQRQDLDgsgYPLDLGSGSLPTLTSGADDDGTTTS----------LALYAQDTYKLTDKLT 372

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  570 LDLVLRNDASSRFSEKHRNAMFWSAGllwKAKKEDFLANVdwlnSLDFKASYGTQGNANIGNYESYATVGDggkyMNNPG 649
Cdd:COG1629    373 LTAGLRYDYVSYDVDDTVTGTDSASG---SRSYSAFSPSL----GLTYQLSPNLSLYASYSRGFRAPTFGE----LYANG 441

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  650 WKIAKAGNDELTWESQDKLTVGVAATLFD-RLSIDFEFYNRLTRNMLMDVPQPYTSGlklddmdFASIKQNVGSYQNRGV 728
Cdd:COG1629    442 TDPYSVGNPDLKPETSTNYELGLRYRLLDgRLSLSLALFYSDVDNEILSVPLPNDSG-------FSTYYTNAGKARSYGV 514

                          650       660
                   ....*....|....*....|....*
gi 1092786850  729 DIKITGDIVRgkdyGVSGYFNFNYN 753
Cdd:COG1629    515 ELELSYQLTP----GLSLNASYSYT 535
Plug pfam07715
TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently ...
 112-221 5.47e-15

TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently folding subunit of the TonB-dependent receptors. It acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens the channel.


Pssm-ID: 462243 [Multi-domain]  Cd Length: 107  Bit Score: 71.92  E-value: 5.47e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  112 KVANTSASVVKINSKELQAKPTANIMDAVQGkVAGVKVltSSGEPSERASINFHGkgsLGSDTTpLYILDGVPVSDGL-- 189
Cdd:pfam07715    1 DLRDTPGSVSVVTAEDIEDQGATNLADALRG-VPGVSV--SSGGGGGGSSISIRG---FGSNRV-LVLVDGVPLNSGGgg 73

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1092786850  190 ---IQSLNPNDFESMQFLKdAAATSIYGARAANGV 221
Cdd:pfam07715   74 svdLNSIDPEDIERVEVLK-GPASALYGSGAIGGV 107
PRK10064 PRK10064
catecholate siderophore receptor CirA; Provisional
 84-228 1.72e-05

catecholate siderophore receptor CirA; Provisional


Pssm-ID: 236646 [Multi-domain]  Cd Length: 663  Bit Score: 48.73  E-value: 1.72e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850   84 AAAPNLNIKLVPDTELLDDVVVIGYGTRK-VANTSASVVKINSKELQAKPTANIMDAVqGKVAGVKVltsSGEPSERASI 162
Cdd:PRK10064    14 ASAISCAWPVLAVDDDGETMVVTASAVEQnLKDAPASISVITQEDLQRKPVQNLKDVL-KEVPGVQL---TNEGDNRKGV 89

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1092786850  163 NFHGkgsLGSDTTpLYILDGVPVSdgliqSLNP----NDFESMQFLKDA---------AATSIYGARAANGVIYITTKR 228
Cdd:PRK10064    90 SIRG---LDSSYT-LILIDGKRVN-----SRNAvfrhNDFDLNWIPVDAierievvrgPMSSLYGSDALGGVVNIITKK 159
ligand_gated_channel cd01347
TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) ...
 119-336 6.06e-05

TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.


Pssm-ID: 238657 [Multi-domain]  Cd Length: 635  Bit Score: 47.06  E-value: 6.06e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  119 SVVKINSKELQAKPTANIMDAVQgKVAGVKVltSSGEPSERASINFHGkgsLGSDTTpLYILDGVPVS------DGLIQS 192
Cdd:cd01347      1 SVSVITAEDIEKQPATSLADLLR-RIPGVSV--TRGGGGGGSTISIRG---FGPDRT-LVLVDGLPLAssnygrGVDLNT 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  193 LNPNDFESMQFLKDAAAtSIYGARAANGVIYITTKRgvARERAQISVRTQYGISDLANPGYYKklmntnelfsfWEESGI 272
Cdd:cd01347     74 IPPELIERVEVLKGPSS-ALYGSGAIGGVVNIITKR--PTDEFGGSVTAGYGSDNSGSSGGGG-----------FDVSGA 139

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  273 KSKDEVADLRKTYGNNNTEWWKYY-YQSAPSFQSDINVSGGAG-----RTNYYFSAGYLSQKGIRAGSSY 336
Cdd:cd01347    140 LADDGAFGARLYGAYRDGDGTIDGdGQADDSDEERYNVAGKLDwrpddDTRLTLDAGYQDQDADGPGGTL 209
 
Name Accession Description Interval E-value
OMP_RagA_SusC TIGR04056
TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade ...
 24-1003 0e+00

TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 274948 [Multi-domain]  Cd Length: 981  Bit Score: 681.62  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850   24 ITVKGIVTDERGDGVIGATVRLKsDATVGTMTGMDGDFTLKAKQGELIIVSYVGYKTQEVAAAP--NLNIKLVPDTELLD 101
Cdd:TIGR04056    1 ITVTGVVVDETGEPLIGASVVVK-GTTNGTITDIDGNFSLKVPPGAVLVFSYIGYKTQEVKVKGqkNLNITLKEDTQELD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  102 DVVVIGYGTRKVANTSASVVKINSKELQAKPTANIMDAVQGKVAGVKVLTSSGEPSERASINFHGKGSLGSDTTPLYILD 181
Cdd:TIGR04056   80 EVVVVGYGTQKKKSLTGAVSTVKAKELKKVPVSNLSNALQGKVAGVIITQSSGEPGGDAEIWIRGISSFGGNNSPLYVID 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  182 GVPVSDGlIQSLNPNDFESMQFLKDAAATSIYGARAANGVIYITTKRGVArERAQISVRTQYGIS------DLANPGYYK 255
Cdd:TIGR04056  160 GVPRDNG-LSDLNPEDIESISVLKDASATAIYGSRGANGVILITTKRGKE-GKPKISYNAEFGFStptrlpEMLNAYEYA 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  256 KLMNTNELFSFWEESGIKSKDEVADLRK---TYGNNNTEWWKY-YYQSAPSFQSDINVSGGAGRTNYYFSAGYLSQKGIR 331
Cdd:TIGR04056  238 ELYNEALLNRGSSPPDIYTDEEIEAYRNgldPDLYPNTDWQDEiFKRTAFNQRHNLSVSGGTEKARYYVSLGYYNEEGIL 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  332 AGSSYDKINMRLNLNSSLNDYIKMGINSSVSYDKARISPKSYASKETYVSLATLINPPYITPYKEDGSeYFDEPIPGLGA 411
Cdd:TIGR04056  318 KNSDYKRYNFRANIDAKLTKTLKLSLNVSGSLSKYNNPGGSTSNIWGALMLFPRGTPYSTPPVYSDGY-YPAYNSGNTSL 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  412 YNPkYHMTKDIPF-DKTLYMNVVGNITITPFKNFQLRSMVGVEVADY-TRDRLRLPSWKKLAG---NGTNSKQFSRDVLF 486
Cdd:TIGR04056  397 QNP-YALLNRGYNeNERNRLNGNASLEQKITKGLKLKGTFSYDYSNYkNKKYYKNPYYYNATGganNGYYSESNSRSRNY 475

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  487 STNNVAEYKFSVAdDHHFITLAGHEYINSKYNffsalGSGINDDRLTELQFATKDKTIESKTKEYAFLSFFGQFSYDYQE 566
Cdd:TIGR04056  476 YLEATLNYNRTFG-KHNVSALLGYSQQENKSS-----SYGGLLDDLPSLDAGTSDASVSGSDSEYRLQSLFGRATYSYKD 549

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  567 KYFLDLVLRNDASSRFSEKHRNAMFWSAGLLWKAKKEDFLANV-DWLNSLDFKASYGTQGNANIGNY----ESYATVGDG 641
Cdd:TIGR04056  550 RYLLEFNFRYDGSSRFAKGNRWGFFPSVSLGWRISEEKFMKKLkKWLSFLKLRASYGIVGNDNIGDRypylSLYNLGDGG 629

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  642 -----GKYMNNPGWKIAKAGNDELTWESQDKLTVGVAATLFD-RLSIDFEFYNRLTRNMLMDVPQPYTSGlklddmdFAS 715
Cdd:TIGR04056  630 ynfgtNNGTSVTGITESRYGNPNLKWEKTKKWNLGLDLGFFNnRLSLTVDYYYKKTKDILQSRSLPSVTG-------YSS 702

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  716 IKQNVGSYQNRGVDIKITGDIVRGKDYGVSGYFNFNYNADKIVKLFQGRDEWIlpGYGFGYVVGQPVNFMY-----PIFK 790
Cdd:TIGR04056  703 PYANIGKVKNKGVELSLNYRNKIGKDFSWSVRGNFTYNKNKILELDEGAYLPV--KYPYISKEGGPIGQIYgyiadGLFK 780

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  791 DID--------PKTGDPRWylpkldKDGNpikginnmNDNEVTSDfDESFLeqntGKHRYPPITGGFGFSANWRGLSLDA 862
Cdd:TIGR04056  781 DDDspkqtfgnVRPGDIKY------KDVN--------GDGKIDDD-DRVPI----GYSNTPDLTYGFGNSFSYKGFDLSA 841

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  863 DFAFVLGKWMIANETYFTKNPVAFAGMNTEKDSRNYWKQEGDNARYPSMKYQLATGTATKFDSSL-LSDASFMRLKNLTI 941
Cdd:TIGR04056  842 LFQGSGGGDVFNDGRGFYPFNGGDWGNVLKIVADNRWTPENPNADYPRLSYGDSNNSNNYQASTRwLEDGSYLRLKNLTL 921

                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1092786850  942 GYTFQKKLLEKQNvITGLKVYGTARNLLTFTKFEGIDPEVDSNLSFhTNPNTRQFVLGLEVS 1003
Cdd:TIGR04056  922 GYTLPKKWLKKIG-ISNLRVYFSGQNLFTFSKYKGWDPELQGNDGG-AYPLQRTFSFGVNLT 981
CirA COG1629
Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];
100-753 2.27e-37

Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];


Pssm-ID: 441236 [Multi-domain]  Cd Length: 644  Bit Score: 149.98  E-value: 2.27e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  100 LDDVVVIGYGT-RKVANTSASVVKINSKELQAKPTANIMDAVQgKVAGVKVLTSSGEPSeraSINFHGKGSLGSDttPLY 178
Cdd:COG1629      1 LEEVVVTATRTdESLQDVPGSVSVISREQLEDQPATDLGDLLR-RVPGVSVTSAGGGAG---QISIRGFGGGGNR--VLV 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  179 ILDGVPVSDGL-----IQSLNPNDFESMQFLKDAAATsIYGARAANGVIYITTKRGVARERAQISVrtqygisdlanpgy 253
Cdd:COG1629     75 LVDGVPLNDPSggdggLSYIDPEDIERVEVLRGPSSA-LYGSGALGGVINIVTKKPKDGKGGEVSA-------------- 139

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  254 ykklmntnelfsfweesgikskdevadlrkTYGNNNTewwkyyyqsapsFQSDINVSGGAGRTNYYFSAGYLSQKGIRAG 333
Cdd:COG1629    140 ------------------------------SYGSYGT------------YRASLSLSGGNGKLAYRLSASYRDSDGYRDN 177

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  334 SSYDKINMRLNLNSSLNDYIKMGInsSVSYDKARispksyasketyvslatlinppyitpYKEDGSEYFDEPIPGLGAYN 413
Cdd:COG1629    178 SDSDRYNLRAKLGYQLGDDTRLTL--SASYSDSD--------------------------QDSPGYLTLAALRPRGAMDD 229

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  414 PKYHMTKDipFDKTLYMNVVGNITITPF-KNFQLRSMVGVEVADYTRDRLRLPSWkklAGNGTNSKQFSRDVLFSTNNVA 492
Cdd:COG1629    230 GTNPYSND--TDDNTRDRYSLSLEYEHLgDGLKLSASAYYRYDDTDLDSDFTPTP---ADGGTLEQTDFDNRTYGLELRL 304

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  493 EYKFSVADDHHFitLAGHEYINSKYN---FFSALGSGINDDRLTELQFATKDKTiesktkeyafLSFFGQFSYDYQEKYF 569
Cdd:COG1629    305 TYDLGFGGKHTL--LVGLDYQRQDLDgsgYPLDLGSGSLPTLTSGADDDGTTTS----------LALYAQDTYKLTDKLT 372

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  570 LDLVLRNDASSRFSEKHRNAMFWSAGllwKAKKEDFLANVdwlnSLDFKASYGTQGNANIGNYESYATVGDggkyMNNPG 649
Cdd:COG1629    373 LTAGLRYDYVSYDVDDTVTGTDSASG---SRSYSAFSPSL----GLTYQLSPNLSLYASYSRGFRAPTFGE----LYANG 441

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  650 WKIAKAGNDELTWESQDKLTVGVAATLFD-RLSIDFEFYNRLTRNMLMDVPQPYTSGlklddmdFASIKQNVGSYQNRGV 728
Cdd:COG1629    442 TDPYSVGNPDLKPETSTNYELGLRYRLLDgRLSLSLALFYSDVDNEILSVPLPNDSG-------FSTYYTNAGKARSYGV 514

                          650       660
                   ....*....|....*....|....*
gi 1092786850  729 DIKITGDIVRgkdyGVSGYFNFNYN 753
Cdd:COG1629    515 ELELSYQLTP----GLSLNASYSYT 535
FepA COG4771
Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and ...
 80-753 4.62e-31

Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism];


Pssm-ID: 443803 [Multi-domain]  Cd Length: 612  Bit Score: 129.98  E-value: 4.62e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850   80 TQEVAAAPNLNIKLVPDTELLDDVVVIGYGT-RKVANTSASVVKINSKELQAKPTANIMDAVQgKVAGVKVLTSSGePSE 158
Cdd:COG4771      7 LLLLALAAQAADALAEDATELEEVVVTATRTeQSLSDAPASVSVITAEEIEKLGATDLADALR-LLPGVSVTRSGG-RGG 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  159 RASINFHGkgsLGSDTTpLYILDGVPVSDGL------IQSLNPNDFESMQFLKDAAATsIYGARAANGVIYITTKRGVAR 232
Cdd:COG4771     85 SSGISIRG---LGGDRV-LVLIDGVPVNNPAlggggdLSYIPPDDIERIEVIRGPASA-LYGSDAIGGVINIITKKPTDE 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  233 ERAQISVRtqygisdlanpgyykklmntnelfsfweesgikskdevadlrktYGNNNTEwwkyyyqsapSFQSDINVSGG 312
Cdd:COG4771    160 LEGSVSLG--------------------------------------------YGSNGNG----------TYSGSLSLGGP 185

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  313 AGRTNYYFSAGYLSQKGIR--------AGSSYDKINMRLNLNSSLNDYIKMGINSSVSYDKARISPksyasketyvslat 384
Cdd:COG4771    186 GDKLSFLLSGSYRDRDGYLdyrnggfvGNSGYERYNLNAKLGYRLSDNHRLSLSGGYSRQDRDGGP-------------- 251

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  385 linppyitpykedgseyfdePIPGLGAYNPKYHMTKDIPFDKTlymNVVGNITITPFKNFQLRsmvgvevadYTRDRLRL 464
Cdd:COG4771    252 --------------------PTLGDTEISSDNAGDRDTTTDRG---NYSLRYNGDLGDNLDLS---------LYYSRTDR 299

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  465 PSWKKLAGNGTNSKQFSRDVLFSTNnvAEYKFSVADDHHFItlAGHEYINSKYNfFSALGSGINDDRLTelqfatkdkti 544
Cdd:COG4771    300 DSTNGSLGGSTGSFSDSDDTTYGLE--LDLTYPLGGNHTLT--LGAEYRYDDLD-SSSFLGGADASRDT----------- 363

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  545 esktkeyafLSFFGQFSYDYQEKYFLDLVLRNDASSRFSEKHRNAMFWSAGLLWKAKKEdflanvdwlnsLDFKASYGTq 624
Cdd:COG4771    364 ---------YGLFAQDEWKLTDKLTLTAGLRYDYYSTFGASNYTAFSPRLGLRYDLSDN-----------LTLRASYGR- 422

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  625 GNANIGNYESYATVGDGGKYMNNpgwkiakaGNDELTWESQDKLTVGVAATLFD-RLSIDFEFYNRLTRNMLMDVPQPYT 703
Cdd:COG4771    423 GFRAPSLAELYGSGTGTPGRYVL--------GNPDLKPETSDNYELGLEYRLGNgGLSLSLTGFYTDIKDLIVLVPVGPG 494

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|
gi 1092786850  704 SGlklddmdFASIKQNVGSYQNRGVDIKITGDIvrgkDYGVSGYFNFNYN 753
Cdd:COG4771    495 PG-------DVLQYENVGKARTYGLELELKYRL----GKGLTLTASYTYL 533
BtuB COG4206
Outer membrane cobalamin receptor protein BtuB [Coenzyme transport and metabolism];
103-338 6.61e-31

Outer membrane cobalamin receptor protein BtuB [Coenzyme transport and metabolism];


Pssm-ID: 443355 [Multi-domain]  Cd Length: 276  Bit Score: 123.06  E-value: 6.61e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  103 VVVIGYG-TRKVANTSASVVKINSKELQAKPTANIMDAVQgKVAGVKVlTSSGEPSERASINFHGKGSlgsdTTPLYILD 181
Cdd:COG4206      1 VVVTATRlEQSKSDLTGSVTVIDAEELERSGATSLADALR-RVPGVQV-SSSGGPGSAASISIRGLGS----NQTLVLID 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  182 GVPVSDGL-----IQSLNPNDFESMQFLKDAAAtSIYGARAANGVIYITTKRGVARERAQISVRT-QYGISDLAnpgyyK 255
Cdd:COG4206     75 GVPLNDPSlggvdLSLIPPDDIERIEVLKGAAS-ALYGSDAIGGVINITTKKGKKGFKGSVSASYgSFGTRRLS-----A 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  256 KLMNTNELFSF-WEESGIKSKDEVADLRKTYGNNNTEWWKYYYQSA--PSFQSDINVSGGAGRTNYYFSAGYLSQKGIRA 332
Cdd:COG4206    149 SLSGGAGKFSYsLSASYRRSDGYRYNDPDLRNNDGYENTSLNARLGykLGDNGSLSLSGGYSDSERGYPGAVGSDRNLRL 228


                   ....*.
gi 1092786850  333 GSSYDK 338
Cdd:COG4206    229 SLSLEY 234
Plug pfam07715
TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently ...
 112-221 5.47e-15

TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently folding subunit of the TonB-dependent receptors. It acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens the channel.


Pssm-ID: 462243 [Multi-domain]  Cd Length: 107  Bit Score: 71.92  E-value: 5.47e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  112 KVANTSASVVKINSKELQAKPTANIMDAVQGkVAGVKVltSSGEPSERASINFHGkgsLGSDTTpLYILDGVPVSDGL-- 189
Cdd:pfam07715    1 DLRDTPGSVSVVTAEDIEDQGATNLADALRG-VPGVSV--SSGGGGGGSSISIRG---FGSNRV-LVLVDGVPLNSGGgg 73

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1092786850  190 ---IQSLNPNDFESMQFLKdAAATSIYGARAANGV 221
Cdd:pfam07715   74 svdLNSIDPEDIERVEVLK-GPASALYGSGAIGGV 107
CarbopepD_reg_2 pfam13715
CarboxypepD_reg-like domain; This domain family is found in bacteria, archaea and eukaryotes, ...
 26-105 1.62e-13

CarboxypepD_reg-like domain; This domain family is found in bacteria, archaea and eukaryotes, and is approximately 90 amino acids in length. The family is found in association with pfam07715 and pfam00593.


Pssm-ID: 433425 [Multi-domain]  Cd Length: 88  Bit Score: 66.85  E-value: 1.62e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850   26 VKGIVTDER-GDGVIGATVRLKSdATVGTMTGMDGDFTLKA-KQGEL-IIVSYVGYKTQEV------AAAPNLNIKLVPD 96
Cdd:pfam13715    1 ISGTVVDENtGEPLPGATVYVKG-TTKGTVTDADGNFELKNlPAGTYtLVVSFVGYKTQEKkvtvsnDNTLDVNFLLKED 79


                   ....*....
gi 1092786850   97 TELLDDVVV 105
Cdd:pfam13715   80 ALLLDEVVV 88
SusC_RagA_signa TIGR04057
TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; This model ...
 197-227 8.75e-12

TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; This model describes a 31-residue signature region of the SusC/RagA family of outer membrane proteins from the Bacteriodetes. While many TonB-dependent outer membrane receptors are associated with siderophore import, this family seems to include generalized nutrient receptors that may convey fairly large oligomers of protein or carbohydrate. This family occurs in high copy numbers in the most abundant species of the human gut microbiome.


Pssm-ID: 274949 [Multi-domain]  Cd Length: 31  Bit Score: 60.29  E-value: 8.75e-12
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1092786850  197 DFESMQFLKDAAATSIYGARAANGVIYITTK 227
Cdd:TIGR04057    1 DIESISVLKDASAAAIYGSRGANGVILITTK 31
FecA COG4772
Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];
84-351 2.28e-08

Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];


Pssm-ID: 443804 [Multi-domain]  Cd Length: 681  Bit Score: 58.02  E-value: 2.28e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850   84 AAAPNLNIKLVPDTELLDDVVVIGYGT--RKVANTSASVVKINSKELQAKPTANIMDAVQgKVAGVKVLTSSGePSERAS 161
Cdd:COG4772      7 AALLLAAAAAAEAATTLETVVVTGSRAaeARLKDVPGSVSVVDREELENQAATSLREVLR-RVPGVNVQEEDG-FGLRPN 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  162 INFHGKGSLGSDTTPLYiLDGVPV-----SDGLIQ-SLNPNDFESMQFLKDAAATsIYGARAANGVIYITTKRGVARERA 235
Cdd:COG4772     85 IGIRGLGPRRSRGITLL-EDGIPIapapyGDPAAYyFPDLERMERIEVLRGAAAL-RYGPQTVGGAINFVTRTIPTAFGG 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  236 QISVrtqygisdlanpgyykklmntnelfsfweesgikskdevadlrkTYGNNNTewwkyyyqsapsFQSDINVSGGAGR 315
Cdd:COG4772    163 ELRV--------------------------------------------TGGSFGY------------RRTHASVGGTVGN 186

                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 1092786850  316 TNYYFSAGYLSQKGIRAGSSYDKINMRLNLNSSLND 351
Cdd:COG4772    187 FGYLVEYSRKRGDGFRDNSGFDINDFNAKLGYRLSD 222
CarboxypepD_reg pfam13620
Carboxypeptidase regulatory-like domain;
25-93 3.74e-08

Carboxypeptidase regulatory-like domain;


Pssm-ID: 433354 [Multi-domain]  Cd Length: 81  Bit Score: 51.51  E-value: 3.74e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850   25 TVKGIVTDERGDGVIGATVRLKSDAT---VGTMTGMDGDFTLKA-KQGE-LIIVSYVGYKTQE-------VAAAPNLNIK 92
Cdd:pfam13620    1 TISGTVTDPSGAPVPGATVTVTNTDTgtvRTTTTDADGRYRFPGlPPGTyTVTVSAPGFKTATrtgvtvtAGQTTTLDVT 80


                   .
gi 1092786850   93 L 93
Cdd:pfam13620   81 L 81
PRK10064 PRK10064
catecholate siderophore receptor CirA; Provisional
 84-228 1.72e-05

catecholate siderophore receptor CirA; Provisional


Pssm-ID: 236646 [Multi-domain]  Cd Length: 663  Bit Score: 48.73  E-value: 1.72e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850   84 AAAPNLNIKLVPDTELLDDVVVIGYGTRK-VANTSASVVKINSKELQAKPTANIMDAVqGKVAGVKVltsSGEPSERASI 162
Cdd:PRK10064    14 ASAISCAWPVLAVDDDGETMVVTASAVEQnLKDAPASISVITQEDLQRKPVQNLKDVL-KEVPGVQL---TNEGDNRKGV 89

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1092786850  163 NFHGkgsLGSDTTpLYILDGVPVSdgliqSLNP----NDFESMQFLKDA---------AATSIYGARAANGVIYITTKR 228
Cdd:PRK10064    90 SIRG---LDSSYT-LILIDGKRVN-----SRNAvfrhNDFDLNWIPVDAierievvrgPMSSLYGSDALGGVVNIITKK 159
PRK13486 PRK13486
TonB-dependent receptor;
101-403 1.77e-05

TonB-dependent receptor;


Pssm-ID: 139606 [Multi-domain]  Cd Length: 696  Bit Score: 48.86  E-value: 1.77e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  101 DDVVVI---GYgTRKVANTSASVVKINSKELQAKPTANIMDAVQGkVAGVKVLTSSGEPserASINFHGKGSLGSDTtpL 177
Cdd:PRK13486    25 EDVMIVsasGY-EKKLTNAAASVSVISQEELQSSQYHDLAEALRS-VEGVDVESGTGKT---GGLEISIRGMPASYT--L 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  178 YILDGvpVSDGLIQSLNPNDFESMQ--FLKDAAA-----------TSIYGARAANGVIYITTKRGVARERAQISVRTQYG 244
Cdd:PRK13486    98 ILIDG--VRQGGSSDVTPNGFSAMNtgFMPPLAAierievirgpmSTLYGSDAMGGVVNIITRKNADKWLSSVNAGLNLQ 175

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  245 ISDlanpgyykKLMNTNElFSFW---------------------EESGIKSKDEVADLRKTYGNNNTEW-------WKYY 296
Cdd:PRK13486   176 ESN--------KWGNSSQ-FNFWssgplvddsvslqvrgstqqrQGSSVTSLSDTAATRIPYPTESQNYnlgarldWKAS 246

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  297 YQSAPSFQSDI-------------NVSGGAGRTNYY----FSAGYLSQKGIRAGSSYdkinmrLNLNSSLNDYIKMgINS 359
Cdd:PRK13486   247 EQDVLWFDMDTtrqrydnrdgqlgSLTGGYDRTLRYernkISAGYDHTFTFGTWKSY------LNWNETENKGREL-VRS 319

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*....
gi 1092786850  360 SVSYDKARISPKSYASKETYVSLATLInppyITPYKED-----GSEYFD 403
Cdd:PRK13486   320 VLKRDKWGLAGQPRELKESNLILNSLL----LTPLGEShlvtvGGEFQS 364
ligand_gated_channel cd01347
TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) ...
 119-336 6.06e-05

TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.


Pssm-ID: 238657 [Multi-domain]  Cd Length: 635  Bit Score: 47.06  E-value: 6.06e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  119 SVVKINSKELQAKPTANIMDAVQgKVAGVKVltSSGEPSERASINFHGkgsLGSDTTpLYILDGVPVS------DGLIQS 192
Cdd:cd01347      1 SVSVITAEDIEKQPATSLADLLR-RIPGVSV--TRGGGGGGSTISIRG---FGPDRT-LVLVDGLPLAssnygrGVDLNT 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  193 LNPNDFESMQFLKDAAAtSIYGARAANGVIYITTKRgvARERAQISVRTQYGISDLANPGYYKklmntnelfsfWEESGI 272
Cdd:cd01347     74 IPPELIERVEVLKGPSS-ALYGSGAIGGVVNIITKR--PTDEFGGSVTAGYGSDNSGSSGGGG-----------FDVSGA 139

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  273 KSKDEVADLRKTYGNNNTEWWKYY-YQSAPSFQSDINVSGGAG-----RTNYYFSAGYLSQKGIRAGSSY 336
Cdd:cd01347    140 LADDGAFGARLYGAYRDGDGTIDGdGQADDSDEERYNVAGKLDwrpddDTRLTLDAGYQDQDADGPGGTL 209
PRK13484 PRK13484
IreA family TonB-dependent siderophore receptor;
101-227 6.11e-05

IreA family TonB-dependent siderophore receptor;


Pssm-ID: 139605 [Multi-domain]  Cd Length: 682  Bit Score: 46.92  E-value: 6.11e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  101 DDVVVIGYG-TRKVANTSASVVKINSKELQAKPTANIMDAVQGkVAGVKV--------LTSSGEPSERASINFHGKGSLG 171
Cdd:PRK13484    31 DTLVVTASGfTQQLRNAPASVSVITSEQLQKKPVSDLVDAVKD-VEGISItggnekpdISIRGLSGDYTLILVDGRRQSG 109

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1092786850  172 SDTTPlyilDGvpvSDGLIQSLNP--NDFESMQFLKdAAATSIYGARAANGVIYITTK 227
Cdd:PRK13484   110 RESRP----NG---SGGFEAGFIPpvEAIERIEVIR-GPMSSLYGSDAIGGVINIITK 159
TonB_dep_Rec pfam00593
TonB dependent receptor; This model now only covers the conserved part of the barrel structure.
 455-736 1.45e-04

TonB dependent receptor; This model now only covers the conserved part of the barrel structure.


Pssm-ID: 395474 [Multi-domain]  Cd Length: 475  Bit Score: 45.53  E-value: 1.45e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  455 ADYTRDRLRLPSWKKLAGNGTNSKQFSRDVLFST-NNVAEYKFSVADDHHFitlaGHEYINSKYNFFSALGSGINDdrlT 533
Cdd:pfam00593   85 LRYSSLDGDYTSNSSGLSGAGDYLSDDRLYGLYGlDGDLELSLDLSHDLLL----GVELRTAGLDYRRLDDDAYDP---Y 157

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  534 ELQFATKDKTIESKTKEYAFlsfFGQFSYDYQEKYFLDLVLRNDASSRFSE----------KHRNAMFWSAGLLWKAkke 603
Cdd:pfam00593  158 DPANPSSSSYSDTTTDSYGL---YLQDNIKLTDRLTLTLGLRYDHYSTDGDdgngggdnfsRSYSAFSPRLGLVYKP--- 231

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  604 dflanvdwLNSLDFKASYGTQGNANIGNYESYATVGDGGKYMNNpgwkiakaGNDELTWESQDKLTVGVAATlFDRLSID 683
Cdd:pfam00593  232 --------TDNLSLYASYSRGFRAPSLGELYGSGSGGGGGAVAG--------GNPDLKPETSDNYELGLKYD-DGRLSLS 294

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1092786850  684 FEFYNRLTRNMLMDVPQPYTSGlklddmDFASIKQNVGSYQNRGVDIKITGDI 736
Cdd:pfam00593  295 LALFYIDIKNLITSDPDGPGLG------GTVYTYTNVGKARIRGVELELSGRL 341
Fiu COG4774
Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism];
109-244 1.84e-04

Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism];


Pssm-ID: 443806 [Multi-domain]  Cd Length: 639  Bit Score: 45.25  E-value: 1.84e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  109 GTRKVANTSASVVKINSKELQAKPTANIMDAVQGkVAGVKVLTSSGEPSERASINfhgkgslGSDTTPLYILDGVPVSDG 188
Cdd:COG4774      2 TDTPLLDTPQSVTVVTRELIEDQGATSLADALRN-VPGVTFGAGEGGNGDSFSIR-------GFSASGDIYVDGLRDPGQ 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1092786850  189 liQSLNPNDFESMQFLKDAAATsIYGARAANGVIYITTKRgvARERAQISVRTQYG 244
Cdd:COG4774     74 --YRRDTFNLERVEVLKGPASV-LYGRGSPGGVINLVTKR--PTDEPFTEVTLTYG 124
FhuE COG4773
Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion ...
 70-244 1.90e-04

Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism];


Pssm-ID: 443805 [Multi-domain]  Cd Length: 692  Bit Score: 45.27  E-value: 1.90e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850   70 LIIVSYVGYKTQEVAAAPNLNIklVPDTELLDDVVVIG-------YGTRKVA----------NTSASVVKINSKELQAKP 132
Cdd:COG4773      4 LLAGSGLAAAAAGALAQAAAAA--AAEATTLPEVTVTGtaegtggYTAKSSStatkldtplrETPQSVSVVTRQLIEDQG 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  133 TANIMDAVQgKVAGVKVLTSSGEPSERASINfhgkgslGSDTTPLYIlDGVPVSDGLIQSLNPNDFESMQFLKDAAATsI 212
Cdd:COG4773     82 ATTLDDALR-NVPGVTVSSYDGGGRDSFSIR-------GFSIDNYLR-DGLPLGGFGGGQPDTANLERVEVLKGPAGL-L 151

                          170       180       190
                   ....*....|....*....|....*....|..
gi 1092786850  213 YGARAANGVIYITTKRgvARERAQISVRTQYG 244
Cdd:COG4773    152 YGAGSPGGLVNLVTKR--PTAEPQGEVSLSAG 181
TonB-siderophor TIGR01783
TonB-dependent siderophore receptor; This subfamily model encompasses a wide variety of ...
 115-229 3.53e-04

TonB-dependent siderophore receptor; This subfamily model encompasses a wide variety of TonB-dependent outer membrane siderophore receptors. It has no overlap with TonB receptors known to transport other substances, but is likely incomplete due to lack of characterizations. It is likely that genuine siderophore receptors will be identified which score below the noise cutoff to this model at which point the model should be updated. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273805 [Multi-domain]  Cd Length: 651  Bit Score: 44.33  E-value: 3.53e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092786850  115 NTSASVVKINSKELQAKPTANIMDAVQgKVAGVKVlTSSGEPSERASINFHGKGSLGS-DTTPLyilDGVP-VSDGLIQS 192
Cdd:TIGR01783    1 DIPQSVSVITRQELEDQQAGSLSEALQ-RVPGVVV-GGSGGTTQFGNITIRGFGLEVDiDNVYL---DGVPlLSRGNLAI 75

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1092786850  193 LNPNDFESMQFLKDAAATsIYGARAANGVIYITTKRG 229
Cdd:TIGR01783   76 VDPAMVERVEVLRGPASL-LYGGSAPGGVINIVTKRP 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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