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Conserved domains on  [gi|1092457826|ref|WP_070447875|]
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MULTISPECIES: metalloregulator ArsR/SmtB family transcription factor [Lactobacillaceae]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 16677510)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 30-105 6.48e-29

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


:

Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 99.84  E-value: 6.48e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1092457826  30 MVNIFKAFGDMTRVKIILALSETPLSVGEIADTLDMSQSSISHQLSILKQLNLVSNARRGRNIHYRLSDQHIITIF 105
Cdd:NF033788    1 LAELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
 
Name Accession Description Interval E-value
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 30-105 6.48e-29

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 99.84  E-value: 6.48e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1092457826  30 MVNIFKAFGDMTRVKIILALSETPLSVGEIADTLDMSQSSISHQLSILKQLNLVSNARRGRNIHYRLSDQHIITIF 105
Cdd:NF033788    1 LAELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
22-112 9.13e-29

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 99.96  E-value: 9.13e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092457826  22 PDDTDLEAMVNIFKAFGDMTRVKIILALSETPLSVGEIADTLDMSQSSISHQLSILKQLNLVSNARRGRNIHYRLSDQHI 101
Cdd:COG0640     2 SETKELEELAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEAL 81

                          90
                  ....*....|.
gi 1092457826 102 ITIFNQTKEHI 112
Cdd:COG0640    82 AELLEWLLELL 92
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 33-96 5.88e-21

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 79.76  E-value: 5.88e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1092457826  33 IFKAFGDMTRVKIILALSETPLSVGEIADTLDMSQSSISHQLSILKQLNLVSNARRGRNIHYRL 96
Cdd:NF033789    1 TFKALSDPTRREILELLKEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSL 64
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 34-98 1.27e-18

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 73.87  E-value: 1.27e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1092457826  34 FKAFGDMTRVKIILALSETPLSVGEIADTLDMSQSSISHQLSILKQLNLVSNARRGRNIHYRLSD 98
Cdd:cd00090     1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTD 65
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
44-101 1.65e-16

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 68.01  E-value: 1.65e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1092457826   44 KIILALSETPLSVGEIADTLDMSQSSISHQLSILKQLNLVSNARRGRNIHYRLSDQHI 101
Cdd:smart00418   1 KILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKV 58
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 39-83 2.69e-14

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 61.69  E-value: 2.69e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1092457826  39 DMTRVKIILALSETPLSVGEIADTLDMSQSSISHQLSILKQLNLV 83
Cdd:pfam01022   1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 31-101 2.77e-11

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 55.98  E-value: 2.77e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1092457826  31 VNIFKAFGDMTRVKIILALSET-PLSVGEIADTLDMSQSSISHQLSILKQLNLVSNARRGRNIHYRLSdQHI 101
Cdd:PRK10141    7 LQLFKILSDETRLGIVLLLRESgELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRLS-PHI 77
 
Name Accession Description Interval E-value
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 30-105 6.48e-29

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 99.84  E-value: 6.48e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1092457826  30 MVNIFKAFGDMTRVKIILALSETPLSVGEIADTLDMSQSSISHQLSILKQLNLVSNARRGRNIHYRLSDQHIITIF 105
Cdd:NF033788    1 LAELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
22-112 9.13e-29

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 99.96  E-value: 9.13e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092457826  22 PDDTDLEAMVNIFKAFGDMTRVKIILALSETPLSVGEIADTLDMSQSSISHQLSILKQLNLVSNARRGRNIHYRLSDQHI 101
Cdd:COG0640     2 SETKELEELAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEAL 81

                          90
                  ....*....|.
gi 1092457826 102 ITIFNQTKEHI 112
Cdd:COG0640    82 AELLEWLLELL 92
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 33-96 5.88e-21

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 79.76  E-value: 5.88e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1092457826  33 IFKAFGDMTRVKIILALSETPLSVGEIADTLDMSQSSISHQLSILKQLNLVSNARRGRNIHYRL 96
Cdd:NF033789    1 TFKALSDPTRREILELLKEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSL 64
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 34-98 1.27e-18

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 73.87  E-value: 1.27e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1092457826  34 FKAFGDMTRVKIILALSETPLSVGEIADTLDMSQSSISHQLSILKQLNLVSNARRGRNIHYRLSD 98
Cdd:cd00090     1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTD 65
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
44-101 1.65e-16

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 68.01  E-value: 1.65e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1092457826   44 KIILALSETPLSVGEIADTLDMSQSSISHQLSILKQLNLVSNARRGRNIHYRLSDQHI 101
Cdd:smart00418   1 KILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKV 58
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
25-110 3.54e-16

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 68.06  E-value: 3.54e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092457826  25 TDLEAMVNIFKAFGDMTRVKIILALSETPLSVGEIADTLDMSQSSISHQLSILKQLNLVS----NARRGRNIHYRLSDQH 100
Cdd:COG4189     4 LDDEESLEVLKALASETRLRILRLLAEEPLNVNELAEALGLPKSTVSYHIRKLEEAGLIRteykPGKRGRQKICYLRVDK 83

                          90
                  ....*....|
gi 1092457826 101 IITIFNQTKE 110
Cdd:COG4189    84 ILIVLPGLDE 93
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 39-83 2.69e-14

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 61.69  E-value: 2.69e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1092457826  39 DMTRVKIILALSETPLSVGEIADTLDMSQSSISHQLSILKQLNLV 83
Cdd:pfam01022   1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 31-101 2.77e-11

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 55.98  E-value: 2.77e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1092457826  31 VNIFKAFGDMTRVKIILALSET-PLSVGEIADTLDMSQSSISHQLSILKQLNLVSNARRGRNIHYRLSdQHI 101
Cdd:PRK10141    7 LQLFKILSDETRLGIVLLLRESgELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRLS-PHI 77
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 32-90 3.39e-11

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 54.08  E-value: 3.39e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092457826  32 NIFKAFGDMTRVKIILAL-SETPLSVGEIADTLDMSQSSISHQLSILKQLNLVSNARRGR 90
Cdd:pfam12840   2 DVAEALADPTRLRILRALvGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
41-98 3.61e-10

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 54.11  E-value: 3.61e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1092457826  41 TRVKIILALSETP-LSVGEIADTLDMSQSSISHQLSILKQLNLVSNARRGRNIHYRLSD 98
Cdd:COG3398    98 TPRRILLYLLENPgATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLNP 156
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
42-98 7.08e-09

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 51.82  E-value: 7.08e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1092457826  42 RVKIILALSETPLSVGEIADTLDMSQSSISHQLSILKQLNLVSnaRRGRNihYRLSD 98
Cdd:COG4742    18 RKNILLLLAEGPKTRSELAESLDVSRSTILRQLKELEERGLIE--RDDGE--YELTT 70
GbsR COG1510
DNA-binding transcriptional regulator GbsR, MarR family [Transcription];
28-114 4.88e-08

DNA-binding transcriptional regulator GbsR, MarR family [Transcription];


Pssm-ID: 441119  Cd Length: 164  Bit Score: 48.39  E-value: 4.88e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092457826  28 EAMVNIFKAFGdMTRV--KI--ILALSETPLSVGEIADTLDMSQSSISHQLSILKQLNLVSNARR--GRNIHYRLSD--- 98
Cdd:COG1510    14 EAFGEMGERWG-LPRSagRIyaLLYLSDEPLTADELAEELGVSKSSVSTALRELEDWGLVRRVRKpgDRKDYFRAEKdvw 92

                          90
                  ....*....|....*.
gi 1092457826  99 QHIITIFNQTKEHIIE 114
Cdd:COG1510    93 ELFRRVFRERLRREID 108
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
36-99 7.44e-05

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 40.29  E-value: 7.44e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092457826  36 AFGDMTRVKIILALSE-TPLSVGEIADTLDMSQSSISHQLSILKQLNLV--SNARRGR---NIHYRLSDQ 99
Cdd:COG2345     9 ALADPTRRRILELLKRaGPVTAAELAEALGLTPNAVRRHLDALEEEGLVerETERRGRgrpAKLYRLTEA 78
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
40-99 5.52e-04

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 37.26  E-value: 5.52e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1092457826  40 MTRVKIILALSET-PLSVGEIADTLDMSQSSISHQLSILKQLNLVS---NARRGRNIHYRLSDQ 99
Cdd:COG1846    38 PAQFRVLAALAEAgGLTQSELAERLGLTKSTVSRLLDRLEEKGLVErepDPEDRRAVLVRLTEK 101
HTH_ICLR smart00346
helix_turn_helix isocitrate lyase regulation;
43-96 1.84e-03

helix_turn_helix isocitrate lyase regulation;


Pssm-ID: 214629 [Multi-domain]  Cd Length: 91  Bit Score: 34.87  E-value: 1.84e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1092457826   43 VKIILALSETP--LSVGEIADTLDMSQSSISHQLSILKQLNLVSnaRRGRNIHYRL 96
Cdd:smart00346   8 LAVLRALAEEPggLTLAELAERLGLSKSTAHRLLNTLQELGYVE--QDGQNGRYRL 61
Rrf2 pfam02082
Iron-dependent Transcriptional regulator; Several proteins in this family form iron-sulfur ...
 41-97 3.76e-03

Iron-dependent Transcriptional regulator; Several proteins in this family form iron-sulfur clusters enabling iron dependent DNA transcription regulation. The iron binding is mediated by three conserved cysteine residues. Members of this family can also bind O-acetyl-L-serine, [Fe-S] and nitric oxide (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 396591 [Multi-domain]  Cd Length: 131  Bit Score: 34.84  E-value: 3.76e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1092457826  41 TRVKIILAL--SETPLSVGEIADTLDMSQSSISHQLSILKQLNLVsNARRGRNIHYRLS 97
Cdd:pfam02082   9 LHALLYLALhpGGEPVTSEEIAERQNISPVYLEKILAKLRKAGLV-ESVRGAGGGYRLA 66
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 39-83 3.88e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 33.33  E-value: 3.88e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1092457826  39 DMTRVK--IILALSETP-LSVGEIADTLDMSQSSISHQLSILKQLNLV 83
Cdd:pfam12802   2 GLTPAQfrVLLALARNPgLTVAELARRLGISKQTVSRLVKRLEAKGLV 49
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 44-99 4.37e-03

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 33.73  E-value: 4.37e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1092457826  44 KIILALSETP--LSVGEIADTLDMSQSSISHQLSILKQLNLVSNARRGRNIHYRLSDQ 99
Cdd:COG2512    19 RVLELLRENGgrMTQSEIVKETGWSKSKVSRLLSRLEERGLIEKERVGRENVVELPED 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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