NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1002987746|ref|WP_061432273|]
View 

ATP-binding protein [Microcystis aeruginosa]

Protein Classification

COG4251 family protein( domain architecture ID 11468125)

COG4251 family protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 478-743 9.87e-120

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


:

Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 369.50  E-value: 9.87e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 478 ETVRLKSLPWKAVEINAALELRKAIVNIILKQADELARLARDLELSNAELKKFAYVASHDLQEPLNQVANYVQLLEMRYT 557
Cdd:COG4251   233 LLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAELERSNEELEQFAYVASHDLREPLRKISGFSQLLEEDYG 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 558 EELDEDAKEFITFAVEGVSLMQTLIDDVLAYSKVDMQAVEFNTIDANLALEKALANLKGRIQESQAIITVDPLPIVMADK 637
Cdd:COG4251   313 DKLDEEGREYLERIRDAAERMQALIDDLLAYSRVGRQELEFEPVDLNELLEEVLEDLEPRIEERGAEIEVGPLPTVRGDP 392

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 638 TQLMQLFQNLIGNAIKFRGK-ATPTIHIAAQRQEEEWLFSVTDNGIGIDPRFSERIFVIFQRLHTRDEYPGTGMGLAICK 716
Cdd:COG4251   393 TLLRQVFQNLISNAIKYSRPgEPPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRDEYEGTGIGLAIVK 472

                         250       260
                  ....*....|....*....|....*..
gi 1002987746 717 KIIECHRGRIWVESQLGKGAVFYFTIP 743
Cdd:COG4251   473 KIVERHGGRIWVESEPGEGATFYFTLP 499
PHY pfam00360
Phytochrome region; Phytochromes are red/far-red photochromic biliprotein photoreceptors which ...
 332-506 3.61e-81

Phytochrome region; Phytochromes are red/far-red photochromic biliprotein photoreceptors which regulate plant development. They are widely represented in both photosynthetic and non-photosynthetic bacteria and are known in a variety of fungi. Although sequence similarities are low, this domain is structurally related to pfam01590, which is generally located immediately N-terminal to this domain. Compared with pfam01590, this domain carries an additional tongue-like hairpin loop between the fifth beta-sheet and the sixth alpha-helix which functions to seal the chromophore pocket and stabilize the photoactivated far-red-absorbing state (Pfr). The tongue carries a conserved PRxSF motif, from which an arginine finger points into the chromophore pocket close to ring D forming a salt bridge with a conserved aspartate residue.


:

Pssm-ID: 425635  Cd Length: 178  Bit Score: 256.81  E-value: 3.61e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 332 VQSQLIDYMAEANNFIDGLIAHKPNLLDLTKATGAAICLGGNYTLIGVTPSEEELNYLITWLEKNVHEDVYYTNSLPRIY 411
Cdd:pfam00360   4 IQDRLVEAMARADDLVDGLVDQSPNLLDLVKADGAALCFGGNLLTLGETPPEEAIRDLAQWLGRNHDSEVFSTDSLSQAY 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 412 ADAGKFKDIASGLLAIPIS--KRNYLLWFRPEVIQTVNWGGDPGKAMEttAIDGDIRLCPRKSFSLWKETVRLKSLPWKA 489
Cdd:pfam00360  84 PEAAALADVASGLLAIPISrkPGNYLLWFRPEVVRTVNWGGDPHKAVE--IDPGGVRLSPRKSFDAWKETVRGRSLPWSE 161

                         170
                  ....*....|....*..
gi 1002987746 490 VEINAALELRKAIVNII 506
Cdd:pfam00360 162 VEIEAARELREALLGVV 178
PAS_2 pfam08446
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 13-123 1.16e-30

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.


:

Pssm-ID: 400652  Cd Length: 107  Bit Score: 116.20  E-value: 1.16e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746  13 LEREPIHLYNRIQPHGVLLVLSEPELKVSQTSSNSRSLLGISPGEIIGKTLEEIFDPFQIDPLKSAIENNDFDAINPSKI 92
Cdd:pfam08446   1 CYLEPIQRPGLIQPHGCLLAVDEPSLRVLQYSENAAEMLGLPAEDLLGTDLRDLFGASSASLLRKALAAGEISLLNPILI 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1002987746  93 WARVkgdDFAVFDAIFHRnAEQMLILELEPA 123
Cdd:pfam08446  81 HSRT---SGKPFYAILHR-SDGGLVLELEPA 107
GAF smart00065
Domain present in phytochromes and cGMP-specific phosphodiesterases; Mutations within these ...
 151-328 1.26e-15

Domain present in phytochromes and cGMP-specific phosphodiesterases; Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa.


:

Pssm-ID: 214500 [Multi-domain]  Cd Length: 149  Bit Score: 74.73  E-value: 1.26e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746  151 LKDFCNIIVKEVRKMTGFDRVMLYKFDEEDNGDVIAEDKIEQLEPYLGLRYPASDipLPARNLLSANWIRQIPDATSEPV 230
Cdd:smart00065   2 LEELLQTILEELRQLLGADRVLIYLVDENDRGELVLVAADGLTLPTLGIRFPLDE--GLAGRVAETGRPLNIPDVEADPL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746  231 DLVPSLhpetqqplnltlsslrsaspchleyLHNMGVGASLTISLIENKRLWGIIACHHrtpKYVPYELRKACEFLGRVI 310
Cdd:smart00065  80 FAEDLL-------------------------GRYQGVRSFLAVPLVADGELVGVLALHN---KKSPRPFTEEDEELLQAL 131

                          170
                   ....*....|....*...
gi 1002987746  311 FSEISAREETEDYDYRVK 328
Cdd:smart00065 132 ANQLAIALANAQLYEELR 149
 
Name Accession Description Interval E-value
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 478-743 9.87e-120

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 369.50  E-value: 9.87e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 478 ETVRLKSLPWKAVEINAALELRKAIVNIILKQADELARLARDLELSNAELKKFAYVASHDLQEPLNQVANYVQLLEMRYT 557
Cdd:COG4251   233 LLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAELERSNEELEQFAYVASHDLREPLRKISGFSQLLEEDYG 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 558 EELDEDAKEFITFAVEGVSLMQTLIDDVLAYSKVDMQAVEFNTIDANLALEKALANLKGRIQESQAIITVDPLPIVMADK 637
Cdd:COG4251   313 DKLDEEGREYLERIRDAAERMQALIDDLLAYSRVGRQELEFEPVDLNELLEEVLEDLEPRIEERGAEIEVGPLPTVRGDP 392

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 638 TQLMQLFQNLIGNAIKFRGK-ATPTIHIAAQRQEEEWLFSVTDNGIGIDPRFSERIFVIFQRLHTRDEYPGTGMGLAICK 716
Cdd:COG4251   393 TLLRQVFQNLISNAIKYSRPgEPPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRDEYEGTGIGLAIVK 472

                         250       260
                  ....*....|....*....|....*..
gi 1002987746 717 KIIECHRGRIWVESQLGKGAVFYFTIP 743
Cdd:COG4251   473 KIVERHGGRIWVESEPGEGATFYFTLP 499
PHY pfam00360
Phytochrome region; Phytochromes are red/far-red photochromic biliprotein photoreceptors which ...
 332-506 3.61e-81

Phytochrome region; Phytochromes are red/far-red photochromic biliprotein photoreceptors which regulate plant development. They are widely represented in both photosynthetic and non-photosynthetic bacteria and are known in a variety of fungi. Although sequence similarities are low, this domain is structurally related to pfam01590, which is generally located immediately N-terminal to this domain. Compared with pfam01590, this domain carries an additional tongue-like hairpin loop between the fifth beta-sheet and the sixth alpha-helix which functions to seal the chromophore pocket and stabilize the photoactivated far-red-absorbing state (Pfr). The tongue carries a conserved PRxSF motif, from which an arginine finger points into the chromophore pocket close to ring D forming a salt bridge with a conserved aspartate residue.


Pssm-ID: 425635  Cd Length: 178  Bit Score: 256.81  E-value: 3.61e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 332 VQSQLIDYMAEANNFIDGLIAHKPNLLDLTKATGAAICLGGNYTLIGVTPSEEELNYLITWLEKNVHEDVYYTNSLPRIY 411
Cdd:pfam00360   4 IQDRLVEAMARADDLVDGLVDQSPNLLDLVKADGAALCFGGNLLTLGETPPEEAIRDLAQWLGRNHDSEVFSTDSLSQAY 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 412 ADAGKFKDIASGLLAIPIS--KRNYLLWFRPEVIQTVNWGGDPGKAMEttAIDGDIRLCPRKSFSLWKETVRLKSLPWKA 489
Cdd:pfam00360  84 PEAAALADVASGLLAIPISrkPGNYLLWFRPEVVRTVNWGGDPHKAVE--IDPGGVRLSPRKSFDAWKETVRGRSLPWSE 161

                         170
                  ....*....|....*..
gi 1002987746 490 VEINAALELRKAIVNII 506
Cdd:pfam00360 162 VEIEAARELREALLGVV 178
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 640-743 5.71e-56

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 186.76  E-value: 5.71e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 640 LMQLFQNLIGNAIKFRGK-ATPTIHIAAQRQEEEWLFSVTDNGIGIDPRFSERIFVIFQRLHTRDEYPGTGMGLAICKKI 718
Cdd:cd16921     1 LGQVLTNLLGNAIKFRRPrRPPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSREEYEGTGVGLAIVRKI 80

                          90       100
                  ....*....|....*....|....*
gi 1002987746 719 IECHRGRIWVESQLGKGAVFYFTIP 743
Cdd:cd16921    81 IERHGGRIWLESEPGEGTTFYFTLP 105
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 635-744 2.06e-34

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 126.99  E-value: 2.06e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746  635 ADKTQLMQLFQNLIGNAIKFrGKATPTIHIAAQRQEEEWLFSVTDNGIGIDPRFSERIFVIFQRLHTRD-EYPGTGMGLA 713
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKY-TPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSrKIGGTGLGLS 79

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1002987746  714 ICKKIIECHRGRIWVESQLGKGAVFYFTIPL 744
Cdd:smart00387  80 IVKKLVELHGGEISVESEPGGGTTFTITLPL 110
PRK09303 PRK09303
histidine kinase;
507-754 1.04e-31

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 127.76  E-value: 1.04e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 507 LKQADELARLARDlelsNAELK---KF-----AYVAsHDLQEPLNQVANYVQLLEMRYTEELDEDAKEFIT----FAVEG 574
Cdd:PRK09303  128 LQLSDELFVLRQE----NETLLeqlKFkdrvlAMLA-HDLRTPLTAASLALETLELGQIDEDTELKPALIEqlqdQARRQ 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 575 VSLMQTLIDDVLAYSKVDMQAVEFNTIDANLA------LEKALANLKGRIQESQAIITVDpLPIVMADKTQLMQLFQNLI 648
Cdd:PRK09303  203 LEEIERLITDLLEVGRTRWEALRFNPQKLDLGslcqevILELEKRWLAKSLEIQTDIPSD-LPSVYADQERIRQVLLNLL 281

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 649 GNAIKFrgkaTP---TIHIAAQRQEEEWL-FSVTDNGIGIDPRFSERIFVIFQRLHTRDEYPGTGMGLAICKKIIECHRG 724
Cdd:PRK09303  282 DNAIKY----TPeggTITLSMLHRTTQKVqVSICDTGPGIPEEEQERIFEDRVRLPRDEGTEGYGIGLSVCRRIVRVHYG 357

                         250       260       270
                  ....*....|....*....|....*....|
gi 1002987746 725 RIWVESQLGKGAVFYFTIPLggnererWRG 754
Cdd:PRK09303  358 QIWVDSEPGQGSCFHFTLPV-------YRG 380
PAS_2 pfam08446
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 13-123 1.16e-30

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.


Pssm-ID: 400652  Cd Length: 107  Bit Score: 116.20  E-value: 1.16e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746  13 LEREPIHLYNRIQPHGVLLVLSEPELKVSQTSSNSRSLLGISPGEIIGKTLEEIFDPFQIDPLKSAIENNDFDAINPSKI 92
Cdd:pfam08446   1 CYLEPIQRPGLIQPHGCLLAVDEPSLRVLQYSENAAEMLGLPAEDLLGTDLRDLFGASSASLLRKALAAGEISLLNPILI 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1002987746  93 WARVkgdDFAVFDAIFHRnAEQMLILELEPA 123
Cdd:pfam08446  81 HSRT---SGKPFYAILHR-SDGGLVLELEPA 107
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 635-744 4.20e-30

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 114.77  E-value: 4.20e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 635 ADKTQLMQLFQNLIGNAIKFRGKATP-TIHIaaqRQEEEWLFSVTDNGIGIDPRFSERIFVIFQRLHTRDeYPGTGMGLA 713
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAAKAGEiTVTL---SEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRG-GGGTGLGLS 76

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1002987746 714 ICKKIIECHRGRIWVESQLGKGAVFYFTIPL 744
Cdd:pfam02518  77 IVRKLVELLGGTITVESEPGGGTTVTLTLPL 107
GAF smart00065
Domain present in phytochromes and cGMP-specific phosphodiesterases; Mutations within these ...
 151-328 1.26e-15

Domain present in phytochromes and cGMP-specific phosphodiesterases; Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa.


Pssm-ID: 214500 [Multi-domain]  Cd Length: 149  Bit Score: 74.73  E-value: 1.26e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746  151 LKDFCNIIVKEVRKMTGFDRVMLYKFDEEDNGDVIAEDKIEQLEPYLGLRYPASDipLPARNLLSANWIRQIPDATSEPV 230
Cdd:smart00065   2 LEELLQTILEELRQLLGADRVLIYLVDENDRGELVLVAADGLTLPTLGIRFPLDE--GLAGRVAETGRPLNIPDVEADPL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746  231 DLVPSLhpetqqplnltlsslrsaspchleyLHNMGVGASLTISLIENKRLWGIIACHHrtpKYVPYELRKACEFLGRVI 310
Cdd:smart00065  80 FAEDLL-------------------------GRYQGVRSFLAVPLVADGELVGVLALHN---KKSPRPFTEEDEELLQAL 131

                          170
                   ....*....|....*...
gi 1002987746  311 FSEISAREETEDYDYRVK 328
Cdd:smart00065 132 ANQLAIALANAQLYEELR 149
GAF pfam01590
GAF domain; This domain is present in cGMP-specific phosphodiesterases, adenylyl and guanylyl ...
 150-306 3.72e-12

GAF domain; This domain is present in cGMP-specific phosphodiesterases, adenylyl and guanylyl cyclases, phytochromes, FhlA and NifA. Adenylyl and guanylyl cyclases catalyze ATP and GTP to the second messengers cAMP and cGMP, respectively, these products up-regulating catalytic activity by binding to the regulatory GAF domain(s). The opposite hydrolysis reaction is catalyzed by phosphodiesterase. cGMP-dependent 3',5'-cyclic phosphodiesterase catalyzes the conversion of guanosine 3',5'-cyclic phosphate to guanosine 5'-phosphate. Here too, cGMP regulates catalytic activity by GAF-domain binding. Phytochromes are regulatory photoreceptors in plants and bacteria which exist in two thermally-stable states that are reversibly inter-convertible by light: the Pr state absorbs maximally in the red region of the spectrum, while the Pfr state absorbs maximally in the far-red region. This domain is also found in FhlA (formate hydrogen lyase transcriptional activator) and NifA, a transcriptional activator which is required for activation of most Nif operons which are directly involved in nitrogen fixation. NifA interacts with sigma-54. This domain can bind biliverdine and phycocyanobilin (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 460259 [Multi-domain]  Cd Length: 133  Bit Score: 64.04  E-value: 3.72e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 150 SLKDFCNIIVKEVRKMTGFDRVMLYKFDeedngdviaedkieqlepYLGLRYPASDIplparnllsanwiRQIPDATSEP 229
Cdd:pfam01590   1 DLEEILQTILEELRELLGADRCALYLPD------------------ADGLEYLPPGA-------------RWLKAAGLEI 49

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 230 VDLVPSLHPETQQPLNLTLSSlrsASPCHLE---YLHNMGVGASLTISLIENKRLWGIIACHHRTPKYVPYElrkaCEFL 306
Cdd:pfam01590  50 PPGTGVTVLRTGRPLVVPDAA---GDPRFLDpllLLRNFGIRSLLAVPIIDDGELLGVLVLHHPRPPFTEEE----LELL 122
 
Name Accession Description Interval E-value
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 478-743 9.87e-120

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 369.50  E-value: 9.87e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 478 ETVRLKSLPWKAVEINAALELRKAIVNIILKQADELARLARDLELSNAELKKFAYVASHDLQEPLNQVANYVQLLEMRYT 557
Cdd:COG4251   233 LLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAELERSNEELEQFAYVASHDLREPLRKISGFSQLLEEDYG 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 558 EELDEDAKEFITFAVEGVSLMQTLIDDVLAYSKVDMQAVEFNTIDANLALEKALANLKGRIQESQAIITVDPLPIVMADK 637
Cdd:COG4251   313 DKLDEEGREYLERIRDAAERMQALIDDLLAYSRVGRQELEFEPVDLNELLEEVLEDLEPRIEERGAEIEVGPLPTVRGDP 392

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 638 TQLMQLFQNLIGNAIKFRGK-ATPTIHIAAQRQEEEWLFSVTDNGIGIDPRFSERIFVIFQRLHTRDEYPGTGMGLAICK 716
Cdd:COG4251   393 TLLRQVFQNLISNAIKYSRPgEPPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRDEYEGTGIGLAIVK 472

                         250       260
                  ....*....|....*....|....*..
gi 1002987746 717 KIIECHRGRIWVESQLGKGAVFYFTIP 743
Cdd:COG4251   473 KIVERHGGRIWVESEPGEGATFYFTLP 499
PHY pfam00360
Phytochrome region; Phytochromes are red/far-red photochromic biliprotein photoreceptors which ...
 332-506 3.61e-81

Phytochrome region; Phytochromes are red/far-red photochromic biliprotein photoreceptors which regulate plant development. They are widely represented in both photosynthetic and non-photosynthetic bacteria and are known in a variety of fungi. Although sequence similarities are low, this domain is structurally related to pfam01590, which is generally located immediately N-terminal to this domain. Compared with pfam01590, this domain carries an additional tongue-like hairpin loop between the fifth beta-sheet and the sixth alpha-helix which functions to seal the chromophore pocket and stabilize the photoactivated far-red-absorbing state (Pfr). The tongue carries a conserved PRxSF motif, from which an arginine finger points into the chromophore pocket close to ring D forming a salt bridge with a conserved aspartate residue.


Pssm-ID: 425635  Cd Length: 178  Bit Score: 256.81  E-value: 3.61e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 332 VQSQLIDYMAEANNFIDGLIAHKPNLLDLTKATGAAICLGGNYTLIGVTPSEEELNYLITWLEKNVHEDVYYTNSLPRIY 411
Cdd:pfam00360   4 IQDRLVEAMARADDLVDGLVDQSPNLLDLVKADGAALCFGGNLLTLGETPPEEAIRDLAQWLGRNHDSEVFSTDSLSQAY 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 412 ADAGKFKDIASGLLAIPIS--KRNYLLWFRPEVIQTVNWGGDPGKAMEttAIDGDIRLCPRKSFSLWKETVRLKSLPWKA 489
Cdd:pfam00360  84 PEAAALADVASGLLAIPISrkPGNYLLWFRPEVVRTVNWGGDPHKAVE--IDPGGVRLSPRKSFDAWKETVRGRSLPWSE 161

                         170
                  ....*....|....*..
gi 1002987746 490 VEINAALELRKAIVNII 506
Cdd:pfam00360 162 VEIEAARELREALLGVV 178
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
512-744 1.06e-60

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 204.76  E-value: 1.06e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 512 ELARLARDLELSNAELKKFAYVASHDLQEPLNQVANYVQLLEmRYTEELDEDAKEFITFAVEGVSLMQTLIDDVLAYSKV 591
Cdd:COG2205     1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLL-DEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 592 DMQAVEFN--TIDANLALEKALANLKGRIQESQAIITVD---PLPIVMADKTQLMQLFQNLIGNAIKFrGKATPTIHIAA 666
Cdd:COG2205    80 ESGKLSLElePVDLAELLEEAVEELRPLAEEKGIRLELDlppELPLVYADPELLEQVLANLLDNAIKY-SPPGGTITISA 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1002987746 667 QRQEEEWLFSVTDNGIGIDPRFSERIFVIFQRLHTRDEYPGTGMGLAICKKIIECHRGRIWVESQLGKGAVFYFTIPL 744
Cdd:COG2205   159 RREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPL 236
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 640-743 5.71e-56

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 186.76  E-value: 5.71e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 640 LMQLFQNLIGNAIKFRGK-ATPTIHIAAQRQEEEWLFSVTDNGIGIDPRFSERIFVIFQRLHTRDEYPGTGMGLAICKKI 718
Cdd:cd16921     1 LGQVLTNLLGNAIKFRRPrRPPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSREEYEGTGVGLAIVRKI 80

                          90       100
                  ....*....|....*....|....*
gi 1002987746 719 IECHRGRIWVESQLGKGAVFYFTIP 743
Cdd:cd16921    81 IERHGGRIWLESEPGEGTTFYFTLP 105
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
485-745 8.66e-56

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 194.36  E-value: 8.66e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 485 LPWKAVEINAALELRKAIVNIILKQADELARLARDLELSNAELKKFAYVASHDLQEPLNQVANYVQLLEmrytEELDEDA 564
Cdd:COG0642    68 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLL----EELDEEQ 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 565 KEFITFAVEGVSLMQTLIDDVLAYSKVDMQAVEFNTIDANLA--LEKALANLKGRIQESQAIITVD---PLPIVMADKTQ 639
Cdd:COG0642   144 REYLETILRSADRLLRLINDLLDLSRLEAGKLELEPEPVDLAelLEEVVELFRPLAEEKGIELELDlpdDLPTVRGDPDR 223

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 640 LMQLFQNLIGNAIKFrGKATPTIHIAAQRQEEEWLFSVTDNGIGIDPRFSERIFVIFQRLHTRDEYPGTGMGLAICKKII 719
Cdd:COG0642   224 LRQVLLNLLSNAIKY-TPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGGGTGLGLAIVKRIV 302

                         250       260
                  ....*....|....*....|....*.
gi 1002987746 720 ECHRGRIWVESQLGKGAVFYFTIPLG 745
Cdd:COG0642   303 ELHGGTIEVESEPGKGTTFTVTLPLA 328
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
399-744 6.95e-50

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 180.13  E-value: 6.95e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 399 EDVYYTNSLPRIYADAGKFKDIASGLLAIPISKRNYLLWFRPEVIQTVNWGGDPGKAMETTAIDGDIRLCPRKSFSLWKE 478
Cdd:COG5002    37 LLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAA 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 479 TVRLKSLPWKAVEINAALELRKAIVNIILKQADELARLARDLELSNAELKKFAYVASHDLQEPLNQVANYVQLLEMRyTE 558
Cdd:COG5002   117 LLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDG-AA 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 559 ELDEDAKEFITFAVEGVSLMQTLIDDVLAYSKVDMQAVEFNTIDANLA--LEKALANLKGRIQESQAIITVD---PLPIV 633
Cdd:COG5002   196 DDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAelLEEVVEELRPLAEEKGIELELDlpeDPLLV 275

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 634 MADKTQLMQLFQNLIGNAIKFrGKATPTIHIAAQRQEEEWLFSVTDNGIGIDPRFSERIFvifQRLHTRD-----EYPGT 708
Cdd:COG5002   276 LGDPDRLEQVLTNLLDNAIKY-TPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIF---ERFYRVDksrsrETGGT 351

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1002987746 709 GMGLAICKKIIECHRGRIWVESQLGKGAVFYFTIPL 744
Cdd:COG5002   352 GLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPL 387
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 475-744 1.31e-43

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 161.50  E-value: 1.31e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 475 LWKETVRLKSLPWKAVEINAALELRKAIVNIILKQADELARLARDLELSNAELKKF-----------------AYVAsHD 537
Cdd:COG4191    74 GLLRLLLLLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELqeqlvqseklaalgelaAGIA-HE 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 538 LQEPLNQVANYVQLLEMRYTEELD-EDAKEFITFAVEGVSLMQTLIDDVLAYSKVDMQAVEfnTIDANLALEKALANLKG 616
Cdd:COG4191   153 INNPLAAILGNAELLRRRLEDEPDpEELREALERILEGAERAAEIVRSLRAFSRRDEEERE--PVDLNELIDEALELLRP 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 617 RIQESQAIITVD---PLPIVMADKTQLMQLFQNLIGNAIK-FRGKATPTIHIAAQRQEEEWLFSVTDNGIGIDPRFSERI 692
Cdd:COG4191   231 RLKARGIEVELDlppDLPPVLGDPGQLEQVLLNLLINAIDaMEEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERI 310

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1002987746 693 FVIFqrLHTRDEYPGTGMGLAICKKIIECHRGRIWVESQLGKGAVFYFTIPL 744
Cdd:COG4191   311 FEPF--FTTKPVGKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPL 360
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 511-748 8.38e-36

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 140.48  E-value: 8.38e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 511 DELARLARDLELsnAELKKFAYVASHDLQEPLNQVANYVQLLEMRYTEELDEDA---KEFITFAVEGVSLMQTLIDDVLA 587
Cdd:COG5000   187 DDITELLRAERL--AAWGELARRIAHEIKNPLTPIQLSAERLRRKLADKLEEDRedlERALDTIIRQVDRLKRIVDEFLD 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 588 YSKvdMQAVEFNTIDANLALEKALANLKGRIQESQAIITVD---PLPIVMADKTQLMQLFQNLIGNAIKFrGKATPTIHI 664
Cdd:COG5000   265 FAR--LPEPQLEPVDLNELLREVLALYEPALKEKDIRLELDldpDLPEVLADRDQLEQVLINLLKNAIEA-IEEGGEIEV 341

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 665 AAQRQEEEWLFSVTDNGIGIDPRFSERIFVIFQRlhTRDEypGTGMGLAICKKIIECHRGRIWVESQLGKGAVFYFTIPL 744
Cdd:COG5000   342 STRREDGRVRIEVSDNGPGIPEEVLERIFEPFFT--TKPK--GTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPL 417


                  ....
gi 1002987746 745 GGNE 748
Cdd:COG5000   418 AEEA 421
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 635-744 2.06e-34

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 126.99  E-value: 2.06e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746  635 ADKTQLMQLFQNLIGNAIKFrGKATPTIHIAAQRQEEEWLFSVTDNGIGIDPRFSERIFVIFQRLHTRD-EYPGTGMGLA 713
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKY-TPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSrKIGGTGLGLS 79

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1002987746  714 ICKKIIECHRGRIWVESQLGKGAVFYFTIPL 744
Cdd:smart00387  80 IVKKLVELHGGEISVESEPGGGTTFTITLPL 110
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
505-744 4.46e-34

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 134.20  E-value: 4.46e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 505 IILKQADELARLARDLEL-----SNAELkkfayVAS--HDLQEPLNQVANYVQLLEMRYTeelDEDAKEFITFAVEGVSL 577
Cdd:COG3852   111 LVLRDITERKRLERELRRaeklaAVGEL-----AAGlaHEIRNPLTGIRGAAQLLERELP---DDELREYTQLIIEEADR 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 578 MQTLIDDVLAYSKvdMQAVEFNTIDANLALEKALANLKGRIQESQAIIT-VDP-LPIVMADKTQLMQLFQNLIGNA---- 651
Cdd:COG3852   183 LNNLVDRLLSFSR--PRPPEREPVNLHEVLERVLELLRAEAPKNIRIVRdYDPsLPEVLGDPDQLIQVLLNLVRNAaeam 260

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 652 -----IKFRGKATPTIHIAAQRQEEEWLFSVTDNGIGIDPRFSERIFVIFQRlhTRDEypGTGMGLAICKKIIECHRGRI 726
Cdd:COG3852   261 peggtITIRTRVERQVTLGGLRPRLYVRIEVIDNGPGIPEEILDRIFEPFFT--TKEK--GTGLGLAIVQKIVEQHGGTI 336

                         250
                  ....*....|....*...
gi 1002987746 727 WVESQLGKGAVFYFTIPL 744
Cdd:COG3852   337 EVESEPGKGTTFRIYLPL 354
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 640-744 4.46e-32

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 120.29  E-value: 4.46e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 640 LMQLFQNLIGNAIKF--RGKATPTIHIAAQRQEEEWL-FSVTDNGIGIDPRFSERIFVIFQRL--HTRDEYPGTGMGLAI 714
Cdd:cd16922     1 LRQILLNLLGNAIKFteEGEVTLRVSLEEEEEDGVQLrFSVEDTGIGIPEEQQARLFEPFSQAdsSTTRKYGGTGLGLAI 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1002987746 715 CKKIIECHRGRIWVESQLGKGAVFYFTIPL 744
Cdd:cd16922    81 SKKLVELMGGDISVESEPGQGSTFTFTLPL 110
PRK09303 PRK09303
histidine kinase;
507-754 1.04e-31

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 127.76  E-value: 1.04e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 507 LKQADELARLARDlelsNAELK---KF-----AYVAsHDLQEPLNQVANYVQLLEMRYTEELDEDAKEFIT----FAVEG 574
Cdd:PRK09303  128 LQLSDELFVLRQE----NETLLeqlKFkdrvlAMLA-HDLRTPLTAASLALETLELGQIDEDTELKPALIEqlqdQARRQ 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 575 VSLMQTLIDDVLAYSKVDMQAVEFNTIDANLA------LEKALANLKGRIQESQAIITVDpLPIVMADKTQLMQLFQNLI 648
Cdd:PRK09303  203 LEEIERLITDLLEVGRTRWEALRFNPQKLDLGslcqevILELEKRWLAKSLEIQTDIPSD-LPSVYADQERIRQVLLNLL 281

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 649 GNAIKFrgkaTP---TIHIAAQRQEEEWL-FSVTDNGIGIDPRFSERIFVIFQRLHTRDEYPGTGMGLAICKKIIECHRG 724
Cdd:PRK09303  282 DNAIKY----TPeggTITLSMLHRTTQKVqVSICDTGPGIPEEEQERIFEDRVRLPRDEGTEGYGIGLSVCRRIVRVHYG 357

                         250       260       270
                  ....*....|....*....|....*....|
gi 1002987746 725 RIWVESQLGKGAVFYFTIPLggnererWRG 754
Cdd:PRK09303  358 QIWVDSEPGQGSCFHFTLPV-------YRG 380
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 640-742 5.96e-31

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 116.55  E-value: 5.96e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 640 LMQLFQNLIGNAIKFrGKATPTIHIAAQRQEEEWLFSVTDNGIGIDPRFSERIFVIFQRLHTRDEYPGTGMGLAICKKII 719
Cdd:cd00075     1 LEQVLSNLLDNALKY-SPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREGGGTGLGLAIVRRIV 79

                          90       100
                  ....*....|....*....|...
gi 1002987746 720 ECHRGRIWVESQLGKGAVFYFTI 742
Cdd:cd00075    80 EAHGGRITVESEPGGGTTFTVTL 102
PAS_2 pfam08446
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 13-123 1.16e-30

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.


Pssm-ID: 400652  Cd Length: 107  Bit Score: 116.20  E-value: 1.16e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746  13 LEREPIHLYNRIQPHGVLLVLSEPELKVSQTSSNSRSLLGISPGEIIGKTLEEIFDPFQIDPLKSAIENNDFDAINPSKI 92
Cdd:pfam08446   1 CYLEPIQRPGLIQPHGCLLAVDEPSLRVLQYSENAAEMLGLPAEDLLGTDLRDLFGASSASLLRKALAAGEISLLNPILI 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1002987746  93 WARVkgdDFAVFDAIFHRnAEQMLILELEPA 123
Cdd:pfam08446  81 HSRT---SGKPFYAILHR-SDGGLVLELEPA 107
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 635-744 4.20e-30

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 114.77  E-value: 4.20e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 635 ADKTQLMQLFQNLIGNAIKFRGKATP-TIHIaaqRQEEEWLFSVTDNGIGIDPRFSERIFVIFQRLHTRDeYPGTGMGLA 713
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAAKAGEiTVTL---SEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRG-GGGTGLGLS 76

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1002987746 714 ICKKIIECHRGRIWVESQLGKGAVFYFTIPL 744
Cdd:pfam02518  77 IVRKLVELLGGTITVESEPGGGTTVTLTLPL 107
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 530-751 1.72e-27

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 117.00  E-value: 1.72e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 530 FAYVASHDLQEPLNQVANYVQLLEMryteELDEDAKEFITFAVEGVSLMQTLIDDVLAYSKVdmQAVEFNTIDANLALEK 609
Cdd:COG5809   273 LAAGIAHEIRNPLTSLKGFIQLLKD----TIDEEQKTYLDIMLSELDRIESIISEFLVLAKP--QAIKYEPKDLNTLIEE 346

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 610 ALAnlkgrIQESQAI--------ITVDPLPIVMADKTQLMQLFQNLIGNAIKfrgkATP---TIHIAAQRQEEEW-LFSV 677
Cdd:COG5809   347 VIP-----LLQPQALlknvqielELEDDIPDILGDENQLKQVFINLLKNAIE----AMPeggNITIETKAEDDDKvVISV 417

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1002987746 678 TDNGIGIDPrfsERIFVIFQRLHTRDEyPGTGMGLAICKKIIECHRGRIWVESQLGKGAVFYFTIPLGGNERER 751
Cdd:COG5809   418 TDEGCGIPE---ERLKKLGEPFYTTKE-KGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIKLSEQVS 487
KinD COG5808
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ...
 515-744 1.35e-24

Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444510 [Multi-domain]  Cd Length: 454  Bit Score: 107.91  E-value: 1.35e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 515 RLARDLELSNAELKK----FAYVASHDLQEPLNQVANYVQLLEMRYTEELDEDakeFITFAVEGVSLMQTLIDDVLAYSK 590
Cdd:COG5808   225 LLERVIQEINTQKLEligtFAASTAHEIRNPLTSIKGFIQLLQEKYPELEDQK---YFDIIQEEIQRINQIVSEFLVLGK 301

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 591 ---VDMQAVEFNTIDANLALE-KALANLKGRIQESQAiiTVDPLPIvMADKTQLMQLFQNLIGNAIKFRgKATPTIHIAA 666
Cdd:COG5808   302 ptaKKLELDDLNELIEEILSIiDSEANLKNIRVEKQS--LDEPLHI-KCDKDRIKQVLLNLIKNAIEAM-KEGGKLTISI 377

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1002987746 667 QRQEEEWLFSVTDNGIGIDPRFSERIFvifQRLHTRDEYpGTGMGLAICKKIIECHRGRIWVESQLGKGAVFYFTIPL 744
Cdd:COG5808   378 ENDDEKAVIEVIDNGEGIPEDIIDEIF---EPFVTTKEG-GTGLGLSVCKRIVEMHGGEIDIESEEGKGTTFTIRLPL 451
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 507-744 5.16e-23

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 103.27  E-value: 5.16e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 507 LKQADELarLARDLELSNA-ELKkfAYVAsHDLQEPLNQVANYVQLLEMRyteelDEDAKEFITFAVEGVSLMQTLIDDV 585
Cdd:COG5805   271 KKEAEEL--MARSEKLSIAgQLA--AGIA-HEIRNPLTSIKGFLQLLQPG-----IEDKEEYFDIMLSELDRIESIISEF 340

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 586 LAYSKVdmQAVEFNTIDANLALEKALANLkgriqESQAI--------ITVDPLPIVMADKTQLMQLFQNLIGNAIKfrgk 657
Cdd:COG5805   341 LALAKP--QAVNKEKENINELIQDVVTLL-----ETEAIlhniqirlELLDEDPFIYCDENQIKQVFINLIKNAIE---- 409

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 658 ATP---TIHIAAQRQEEEWLFSVTDNGIGIDPRFSERIFVIFqrLHTRDEypGTGMGLAICKKIIECHRGRIWVESQLGK 734
Cdd:COG5805   410 AMPnggTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPF--FTTKEK--GTGLGLMVSYKIIENHNGTIDIDSKVGK 485

                         250
                  ....*....|
gi 1002987746 735 GAVFYFTIPL 744
Cdd:COG5805   486 GTTFTITLPL 495
PRK10490 PRK10490
sensor protein KdpD; Provisional
 507-745 1.17e-22

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 103.96  E-value: 1.17e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 507 LKQADELARLARDLE-LSNAELKKFayvaSHDLQEPLNQVANYVQLLEMRYTEELDEDAKEfitfavegVSLM--QTLID 583
Cdd:PRK10490  647 LTASEEQARLASEREqLRNALLAAL----SHDLRTPLTVLFGQAEILTLDLASEGSPHARQ--------ASEIrqQVLNT 714

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 584 DVLAYSKVDM---QAVEFNTIDANLALEK----ALANLKGRIQESQAIITV-DPLPIVMADKTQLMQLFQNLIGNAIKFR 655
Cdd:PRK10490  715 TRLVNNLLDMariQSGGFNLRKEWLTLEEvvgsALQMLEPGLSGHPINLSLpEPLTLIHVDGPLFERVLINLLENAVKYA 794

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 656 GKATPtIHIAAQRQEEEWLFSVTDNGIGIDPRFSERIFVIFQRLHTRDEYPGTGMGLAICKKIIECHRGRIWVESQLGKG 735
Cdd:PRK10490  795 GAQAE-IGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKESAIPGVGLGLAICRAIVEVHGGTIWAENRPEGG 873

                         250
                  ....*....|
gi 1002987746 736 AVFYFTIPLG 745
Cdd:PRK10490  874 ACFRVTLPLE 883
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
515-744 9.52e-22

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 100.04  E-value: 9.52e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 515 RLARDLELsnAELKKFAYVASHDLQEPLNQVANYVQLLEmryTEELDEDAKEFITFAVEGVSLMQTLIDDVLAYSK---V 591
Cdd:PRK11360  380 RVARQERL--AALGELVAGVAHEIRNPLTAIRGYVQIWR---QQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFSRpreS 454

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 592 DMQAVEFNTIdanlaLEKALANLKGRIQESQAIITVD---PLPIVMADKTQLMQLFQNLIGN---AIKFRGKATPTIHIA 665
Cdd:PRK11360  455 QWQPVSLNAL-----VEEVLQLFQTAGVQARVDFETEldnELPPIWADPELLKQVLLNILINavqAISARGKIRIRTWQY 529

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1002987746 666 AQRQEEewlFSVTDNGIGIDPRFSERIFVIFqrLHTRDEypGTGMGLAICKKIIECHRGRIWVESQLGKGAVFYFTIPL 744
Cdd:PRK11360  530 SDGQVA---VSIEDNGCGIDPELLKKIFDPF--FTTKAK--GTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPI 601
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 640-744 3.33e-20

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 86.23  E-value: 3.33e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 640 LMQLFQNLIGNAIKFrgkATPTIHIAAQRQEEEWLFSVTDNGIGIDPRFSERIFVIFQRLHT-RD-EYPGTGMGLAICKK 717
Cdd:cd16949     1 LARALENVLRNALRY---SPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSaRDrESGGTGLGLAIAER 77

                          90       100
                  ....*....|....*....|....*..
gi 1002987746 718 IIECHRGRIWVESQLGKGAVFYFTIPL 744
Cdd:cd16949    78 AIEQHGGKIKASNRKPGGLRVRIWLPA 104
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 535-744 1.12e-19

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 94.24  E-value: 1.12e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 535 SHDLQEPLNQVanyVQLLEMRYTEELD-EDAKEFITFAVEGVSLmQTLIDDVLAYSKVDMQAVEF--NTIDANLALEKaL 611
Cdd:PRK11091  291 SHELRTPLNGI---VGLSRILLDTELTaEQRKYLKTIHVSAITL-GNIFNDIIDMDKMERRKLQLdnQPIDFTDFLAD-L 365

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 612 ANLKGRIQESQAIITV----DPLPI-VMADKTQLMQLFQNLIGNAIKFRGKATPTIHIAAQrQEEEWLFSVTDNGIGIDP 686
Cdd:PRK11091  366 ENLSGLQAEQKGLRFDleplLPLPHkVITDGTRLRQILWNLISNAVKFTQQGGVTVRVRYE-EGDMLTFEVEDSGIGIPE 444

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1002987746 687 RFSERIFVIF-QRLHTRDEYP--GTGMGLAICKKIIECHRGRIWVESQLGKGAVFYFTIPL 744
Cdd:PRK11091  445 DELDKIFAMYyQVKDSHGGKPatGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIHA 505
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
510-733 1.28e-19

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 92.77  E-value: 1.28e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 510 ADELARLARDLELSNAELKK-----FAYVA--SHDLQEPLNQVANYVQLLE---MRYTEEldedakEFITFAVEgVSLMQ 579
Cdd:PRK10549  216 RDELGRLAQDFNQLASTLEKneqmrRDFMAdiSHELRTPLAVLRGELEAIQdgvRKFTPE------SVASLQAE-VGTLT 288

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 580 TLIDDV----------LAYSKvdmqavefNTIDANLALEKALANLKGRIQESQAIITVDpLP---IVMADKTQLMQLFQN 646
Cdd:PRK10549  289 KLVDDLhqlslsdegaLAYRK--------TPVDLVPLLEVAGGAFRERFASRGLTLQLS-LPdsaTVFGDPDRLMQLFNN 359

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 647 LIGNAIKFRgKATPTIHIAAQRQEEEWLFSVTDNGIGIDPRFSERIFVIFQRLH-TRDEYPG-TGMGLAICKKIIECHRG 724
Cdd:PRK10549  360 LLENSLRYT-DSGGSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEgSRNRASGgSGLGLAICLNIVEAHNG 438

                         250
                  ....*....|
gi 1002987746 725 RIWVE-SQLG 733
Cdd:PRK10549  439 RIIAAhSPFG 448
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
511-753 2.02e-18

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 88.69  E-value: 2.02e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 511 DELARLARDLELSNAElkkfAYVAsHDLQEPLNQVANYVQLLEMRYTEEldEDAKEFITFAVEGVSLMQTLIDDVLAYSK 590
Cdd:PRK10364  226 DEMKRKEKLVALGHLA----AGVA-HEIRNPLSSIKGLAKYFAERAPAG--GEAHQLAQVMAKEADRLNRVVSELLELVK 298

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 591 ---VDMQAVEFNT-IDANLALEKALANLKGriqeSQAIITVDP-LPIVMADKTQLMQLFQNLIGNAIKFRGKATpTIHIA 665
Cdd:PRK10364  299 pthLALQAVDLNDlINHSLQLVSQDANSRE----IQLRFTANDtLPEIQADPDRLTQVLLNLYLNAIQAIGQHG-VISVT 373

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 666 AQRQEEEWLFSVTDNGIGIDPRFSERIFVIFqrLHTRDEypGTGMGLAICKKIIECHRGRIWVESQLGKGAVFYFTIPLG 745
Cdd:PRK10364  374 ASESGAGVKISVTDSGKGIAADQLEAIFTPY--FTTKAE--GTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVN 449


                  ....*...
gi 1002987746 746 GNERERWR 753
Cdd:PRK10364  450 ITRRDPQG 457
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 511-746 2.26e-18

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 88.75  E-value: 2.26e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 511 DELARLARDLELSNAELKKFAYVAS------HDLQEPLNQVANYVQLLEmrytEELDEDAKEFITFAVEGVSL-MQTLID 583
Cdd:PRK11100  234 SELRELAQALESMRVKLEGKAYVEQyvqtltHELKSPLAAIRGAAELLQ----EDPPPEDRARFTGNILTQSArLQQLID 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 584 DVLAYSKV-------DMQAVEFNTIdanlaLEKALANLKGRIQESQAIITVDPLPI-VMADKTQLMQLFQNLIGNAIKFr 655
Cdd:PRK11100  310 RLLELARLeqrqeleVLEPVALAAL-----LEELVEAREAQAAAKGITLRLRPDDArVLGDPFLLRQALGNLLDNAIDF- 383

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 656 gkaTP---TIHIAAQRQEEEWLFSVTDNGIGI----DPRFSERiFVIFQRLHTRDEypGTGMGLAICKKIIECHRGRIWV 728
Cdd:PRK11100  384 ---SPeggTITLSAEVDGEQVALSVEDQGPGIpdyaLPRIFER-FYSLPRPANGRK--STGLGLAFVREVARLHGGEVTL 457

                         250
                  ....*....|....*...
gi 1002987746 729 ESQLGKGAVFYFTIPLGG 746
Cdd:PRK11100  458 RNRPEGGVLATLTLPRHF 475
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 515-744 3.30e-18

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 89.58  E-value: 3.30e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 515 RLARdLELSNAELKKFAYVA--SHDLQEPLNQVANYVQLLEMRYTEELDEDAKEFITFAveGVSLMqTLIDDVLAYSKVD 592
Cdd:PRK11466  431 RQAR-AEAEKASQAKSAFLAamSHEIRTPLYGILGTAQLLADNPALNAQRDDLRAITDS--GESLL-TILNDILDYSAIE 506

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 593 MQAVEFNTIDANLA----LEKALANLKGRIQESQ-AIIT--VDPLPI-VMADKTQLMQLFQNLIGNAIKFRGKATptIHI 664
Cdd:PRK11466  507 AGGKNVSVSDEPFEprplLESTLQLMSGRVKGRPiRLATdiADDLPTaLMGDPRRIRQVITNLLSNALRFTDEGS--IVL 584

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 665 AAQRQEEEWLFSVTDNGIGIDPRFSERIFVIFQRLHTRDEypGTGMGLAICKKIIECHRGRIWVESQLGKGAVFYFTIPL 744
Cdd:PRK11466  585 RSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKRG--GTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPL 662
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
511-743 6.09e-18

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 86.99  E-value: 6.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 511 DELARLARDL----ELSNAELKKFAYVaSHDLQEPLNQVANYvqlLEMRYTEELD----EDAKEFITfavEGVSLMQTLI 582
Cdd:PRK11006  185 GQLLMVARDVtqmhQLEGARRNFFANV-SHELRTPLTVLQGY---LEMMQDQPLEgalrEKALHTMR---EQTQRMEGLV 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 583 DDVLAYSKVDMQ-AVEFN-TIDANLAL---EKALANLKgriQESQAII-TVDPLPIVMADKTQLMQLFQNLIGNAIKFRG 656
Cdd:PRK11006  258 KQLLTLSKIEAApTIDLNeKVDVPMMLrvlEREAQTLS---QGKHTITfEVDNSLKVFGNEDQLRSAISNLVYNAVNHTP 334

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 657 KATpTIHIAAQRQEEEWLFSVTDNGIGID----PRFSERiFVIFQRLHTRDEyPGTGMGLAICKKIIECHRGRIWVESQL 732
Cdd:PRK11006  335 EGT-HITVRWQRVPQGAEFSVEDNGPGIApehiPRLTER-FYRVDKARSRQT-GGSGLGLAIVKHALSHHDSRLEIESEV 411

                         250
                  ....*....|.
gi 1002987746 733 GKGAVFYFTIP 743
Cdd:PRK11006  412 GKGTRFSFVLP 422
PRK15347 PRK15347
two component system sensor kinase;
512-744 6.55e-18

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 88.55  E-value: 6.55e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 512 ELARLARDLELSNAELKKFAYVASHDLQEPLNQVANYVQLLEmryTEELDEDAKEFITFAVEGVSLMQTLIDDVLAYSKV 591
Cdd:PRK15347  383 ALAEAKQRAEQANKRKSEHLTTISHEIRTPLNGVLGALELLQ---NTPLTAEQMDLADTARQCTLSLLAIINNLLDFSRI 459

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 592 DMQAVEFN--TIDANLALEKALANLKGRIQES----QAIITVD-PLPIVMaDKTQLMQLFQNLIGNAIKFrgkaTPTIHI 664
Cdd:PRK15347  460 ESGQMTLSleETALLPLLDQAMLTIQGPAQSKsltlRTFVGAHvPLYLHL-DSLRLRQILVNLLGNAVKF----TETGGI 534

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 665 A--AQRQEEEWLFSVTDNGIGIDPRFSERIFVIFQRLHTRDEypGTGMGLAICKKIIECHRGRIWVESQLGKGAVFYFTI 742
Cdd:PRK15347  535 RlrVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTHSQ--GTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVL 612


                  ..
gi 1002987746 743 PL 744
Cdd:PRK15347  613 PL 614
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 639-744 1.66e-17

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 78.62  E-value: 1.66e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 639 QLMQLFQNLIGNA---IKFRGKatptIHIAAQRQEEEWLFSVTDNGIGIDPRFSERIFVIFqrLHTRDEYPGTGMGLAIC 715
Cdd:cd16943     3 QLNQVLLNLLVNAaqaMEGRGR----ITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPF--FTTKPVGEGTGLGLSLS 76

                          90       100
                  ....*....|....*....|....*....
gi 1002987746 716 KKIIECHRGRIWVESQLGKGAVFYFTIPL 744
Cdd:cd16943    77 YRIIQKHGGTIRVASVPGGGTRFTIILPI 105
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 640-743 3.79e-17

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 77.44  E-value: 3.79e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 640 LMQLFQNLIGNAIKF-------RGKATPTIHIAAQRqeeEWLFSVTDNGIGIDPRFSERIFVIFqrLHTRDEypGTGMGL 712
Cdd:cd16920     1 IQQVLINLVRNGIEAmseggceRRELTIRTSPADDR---AVTISVKDTGPGIAEEVAGQLFDPF--YTTKSE--GLGMGL 73

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1002987746 713 AICKKIIECHRGRIWVESQLGKGAVFYFTIP 743
Cdd:cd16920    74 SICRSIIEAHGGRLSVESPAGGGATFQFTLP 104
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 498-737 4.41e-17

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 85.51  E-value: 4.41e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 498 LRKAIVNIILKQADELARLAR------DLELSNAELKKFAYVA---------SHDLQEPLNQVANYVQLLEMRYTEELDE 562
Cdd:COG4192   389 LRVFRDQAIEKTQELETEIEErkriekNLRQTQDELIQAAKMAvvgqtmtslAHELNQPLNAMSMYLFSAKKALEQENYA 468

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 563 DAKEFITFAVEGVSLMQTLIDDVLAYSK---VDMQAVEFNTIdanlaLEKALANLKGRIQESQAIITVDPLPIVMADKTQ 639
Cdd:COG4192   469 QLPTSLDKIEGLIERMDKIIKSLRQFSRksdTPLQPVDLRQV-----IEQAWELVESRAKPQQITLHIPDDLMVQGDQVL 543

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 640 LMQLFQNLIGNAIKfRGKATPTIHIAAQRQEEEWLFSVTDNGIGIDprFSERIFVIFqrlhTRDEYPGTGMGLAICKKII 719
Cdd:COG4192   544 LEQVLVNLLVNALD-AVATQPQISVDLLSNAENLRVAISDNGNGWP--LVDKLFTPF----TTTKEVGLGLGLSICRSIM 616

                         250
                  ....*....|....*...
gi 1002987746 720 ECHRGRIWVESQLGKGAV 737
Cdd:COG4192   617 QQFGGDLYLASTLERGAM 634
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 520-748 9.18e-17

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 84.90  E-value: 9.18e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 520 LELSNAEL---KKFAYVA-----------SHDLQEPLNQVANYV-QLLEMryteELDEDAKEFI-TFAVEGVSLMqTLID 583
Cdd:PRK11107  272 MEIQNVELdlaKKRAQEAarikseflanmSHELRTPLNGVIGFTrQTLKT----PLTPTQRDYLqTIERSANNLL-AIIN 346

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 584 DVLAYSKVD-----MQAVEF---NTID------ANLALEKALA---NLKGRIQESqaiitvdplpiVMADKTQLMQLFQN 646
Cdd:PRK11107  347 DILDFSKLEagklvLENIPFslrETLDevvtllAHSAHEKGLEltlNIDPDVPDN-----------VIGDPLRLQQIITN 415

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 647 LIGNAIKFRGKATPTIHIAAQRQEEEWL---FSVTDNGIGIDPRFSERIFVIF-Q------RLHTrdeypGTGMGLAICK 716
Cdd:PRK11107  416 LVGNAIKFTESGNIDILVELRALSNTKVqleVQIRDTGIGISERQQSQLFQAFrQadasisRRHG-----GTGLGLVITQ 490

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1002987746 717 KIIECHRGRIWVESQLGKGAVFYFTIPLGGNE 748
Cdd:PRK11107  491 KLVNEMGGDISFHSQPNRGSTFWFHLPLDLNP 522
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 505-747 1.42e-16

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 82.59  E-value: 1.42e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 505 IILKQADELARLARDLEL---SNAELKKFAyvasHDLQEPLNQVANYVQLLEMryteeldEDAKEFITfavEGVSLMQTL 581
Cdd:COG3290   168 ATFRDRTELERLEEELEGvkeLAEALRAQR----HDFRNHLHTISGLLQLGEY-------DEALEYID---EISEELQEL 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 582 IDDVLAYSKVDMqavefntIDAnLALEKAlanlkGRIQESQAIITVDP---LPIVMADKTQLMQLFQNLIGNAI---KFR 655
Cdd:COG3290   234 IDSLLSRIGNPV-------LAA-LLLGKA-----ARARERGIDLTIDIdsdLPDLPLSDTDLVTILGNLLDNAIeavEKL 300

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 656 GKATPTIHIAAQRQEEEWLFSVTDNGIGIDPRFSERIFvifQRLHTRDEYPGTGMGLAICKKIIECHRGRIWVESQLGKG 735
Cdd:COG3290   301 PEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIF---ERGFSTKLGEGRGLGLALVKQIVEKYGGTIEVESEEGEG 377

                         250
                  ....*....|..
gi 1002987746 736 AVFYFTIPLGGN 747
Cdd:COG3290   378 TVFTVRLPKEGE 389
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 640-740 4.85e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 74.42  E-value: 4.85e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 640 LMQLFQNLIGNAIKFRGK-ATPTIHIAAQRQEEEWLFSVTDNGIGIDPRFSERIFVIFqrLHTRDEYPGTGMGLAICKKI 718
Cdd:cd16976     1 IQQVLMNLLQNALDAMGKvENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPF--FTTKPVGKGTGLGLSISYGI 78

                          90       100
                  ....*....|....*....|..
gi 1002987746 719 IECHRGRIWVESQLGKGAVFYF 740
Cdd:cd16976    79 VEEHGGRLSVANEEGAGARFTF 100
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
535-744 6.30e-16

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 82.33  E-value: 6.30e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 535 SHDLQEPLNQVANYVQLLEmryTEELDEDAKEFITFAVEGVSLMQTLIDDVLAYSKVDMQAV-----EFNT------IDA 603
Cdd:PRK10841  455 SHELRTPLYGIIGNLDLLQ---TKELPKGVDRLVTAMNNSSSLLLKIISDILDFSKIESEQLkieprEFSPrevinhITA 531

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 604 N---LALEKALAnlkgriqeSQAIITVDPLPIVMADKTQLMQLFQNLIGNAIKFrgKATPTIHIAAQRQEEEWLFSVTDN 680
Cdd:PRK10841  532 NylpLVVKKRLG--------LYCFIEPDVPVALNGDPMRLQQVISNLLSNAIKF--TDTGCIVLHVRVDGDYLSFRVRDT 601

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1002987746 681 GIGIDPRFSERIFVIFQRLHTRDE--YPGTGMGLAICKKIIECHRGRIWVESQLGKGAVFYFTIPL 744
Cdd:PRK10841  602 GVGIPAKEVVRLFDPFFQVGTGVQrnFQGTGLGLAICEKLINMMDGDISVDSEPGMGSQFTIRIPL 667
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 640-743 7.06e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 74.16  E-value: 7.06e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 640 LMQLFQNLIGNAIKFRGKATpTIHIAAQRQEEEWLFSVTDNGIGID----PRFSERIFVIfQRLHTRDEyPGTGMGLAIC 715
Cdd:cd16952     1 LRSAFSNLVSNAVKYTPPSD-TITVRWSQEESGARLSVEDTGPGIPpehiPRLTERFYRV-DIERCRNT-GGTGLGLAIV 77

                          90       100
                  ....*....|....*....|....*...
gi 1002987746 716 KKIIECHRGRIWVESQLGKGAVFYFTIP 743
Cdd:cd16952    78 KHVMSRHDARLLIASELGKGSRFTCLFP 105
PRK10604 PRK10604
sensor protein RstB; Provisional
 535-747 7.82e-16

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 80.42  E-value: 7.82e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 535 SHDLQEPLnqvanyVQL---LEMryTEELDEDAKEFITfavEGVSLMQTLIDDVLAYSKVDMQAVEFNTIDANLA--LEK 609
Cdd:PRK10604  220 AHELRTPL------VRLryrLEM--SDNLSAAESQALN---RDIGQLEALIEELLTYARLDRPQNELHLSEPDLPawLST 288

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 610 ALANLKGRIQESQAIITVDPLPIVMADKTQLMQ-LFQNLIGNAIKFrgkATPTIHIAAQRQEEEWLFSVTDNGIGIDPRF 688
Cdd:PRK10604  289 HLADIQAVTPEKTVRLDTPHQGDYGALDMRLMErVLDNLLNNALRY---AHSRVRVSLLLDGNQACLIVEDDGPGIPPEE 365

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1002987746 689 SERIFVIFQRLH-TRDEYPG-TGMGLAICKKIIECHRGRIWVE-SQLGkGAVFYFTIPLGGN 747
Cdd:PRK10604  366 RERVFEPFVRLDpSRDRATGgCGLGLAIVHSIALAMGGSVNCDeSELG-GARFSFSWPVWHN 426
GAF smart00065
Domain present in phytochromes and cGMP-specific phosphodiesterases; Mutations within these ...
 151-328 1.26e-15

Domain present in phytochromes and cGMP-specific phosphodiesterases; Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa.


Pssm-ID: 214500 [Multi-domain]  Cd Length: 149  Bit Score: 74.73  E-value: 1.26e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746  151 LKDFCNIIVKEVRKMTGFDRVMLYKFDEEDNGDVIAEDKIEQLEPYLGLRYPASDipLPARNLLSANWIRQIPDATSEPV 230
Cdd:smart00065   2 LEELLQTILEELRQLLGADRVLIYLVDENDRGELVLVAADGLTLPTLGIRFPLDE--GLAGRVAETGRPLNIPDVEADPL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746  231 DLVPSLhpetqqplnltlsslrsaspchleyLHNMGVGASLTISLIENKRLWGIIACHHrtpKYVPYELRKACEFLGRVI 310
Cdd:smart00065  80 FAEDLL-------------------------GRYQGVRSFLAVPLVADGELVGVLALHN---KKSPRPFTEEDEELLQAL 131

                          170
                   ....*....|....*...
gi 1002987746  311 FSEISAREETEDYDYRVK 328
Cdd:smart00065 132 ANQLAIALANAQLYEELR 149
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 636-733 2.88e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 72.11  E-value: 2.88e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 636 DKTQLMQLFQNLIGNAIKFRgKATPTIHIAAQRQEEEWLFSVTDNGIGIDPRFSERIFVIFQRLHT--RDEYPGTGMGLA 713
Cdd:cd16946     1 DRDRLQQLFVNLLENSLRYT-DTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESsrNRASGGSGLGLA 79

                          90       100
                  ....*....|....*....|.
gi 1002987746 714 ICKKIIECHRGRIWVE-SQLG 733
Cdd:cd16946    80 ICHNIALAHGGTISAEhSPLG 100
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 633-735 4.84e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 71.67  E-value: 4.84e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 633 VMADKTQLMQLFQNLIGNAIKFrgkaTPTIHIAAQRQEEEW--LFSVTDNGIGIDPRFSERIFVIFQRLHTRDeYPGTGM 710
Cdd:cd16940     7 VQGDALLLFLLLRNLVDNAVRY----SPQGSRVEIKLSADDgaVIRVEDNGPGIDEEELEALFERFYRSDGQN-YGGSGL 81

                          90       100
                  ....*....|....*....|....*
gi 1002987746 711 GLAICKKIIECHRGRIWVESQLGKG 735
Cdd:cd16940    82 GLSIVKRIVELHGGQIFLGNAQGGG 106
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 645-744 1.09e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 64.76  E-value: 1.09e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 645 QNLIGNAIKFrgkATPTIHIAAQRQEEEWLFSVTDNGIGIDPRFSERIFVIFQRLH-TRDEY-PGTGMGLAICKKIIECH 722
Cdd:cd16939     6 DNLLRNALRY---AHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDpSRDRAtGGFGLGLAIVHRVALWH 82

                          90       100
                  ....*....|....*....|...
gi 1002987746 723 RGRIWV-ESQLGkGAVFYFTIPL 744
Cdd:cd16939    83 GGHVECdDSELG-GACFRLTWPR 104
GAF pfam01590
GAF domain; This domain is present in cGMP-specific phosphodiesterases, adenylyl and guanylyl ...
 150-306 3.72e-12

GAF domain; This domain is present in cGMP-specific phosphodiesterases, adenylyl and guanylyl cyclases, phytochromes, FhlA and NifA. Adenylyl and guanylyl cyclases catalyze ATP and GTP to the second messengers cAMP and cGMP, respectively, these products up-regulating catalytic activity by binding to the regulatory GAF domain(s). The opposite hydrolysis reaction is catalyzed by phosphodiesterase. cGMP-dependent 3',5'-cyclic phosphodiesterase catalyzes the conversion of guanosine 3',5'-cyclic phosphate to guanosine 5'-phosphate. Here too, cGMP regulates catalytic activity by GAF-domain binding. Phytochromes are regulatory photoreceptors in plants and bacteria which exist in two thermally-stable states that are reversibly inter-convertible by light: the Pr state absorbs maximally in the red region of the spectrum, while the Pfr state absorbs maximally in the far-red region. This domain is also found in FhlA (formate hydrogen lyase transcriptional activator) and NifA, a transcriptional activator which is required for activation of most Nif operons which are directly involved in nitrogen fixation. NifA interacts with sigma-54. This domain can bind biliverdine and phycocyanobilin (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 460259 [Multi-domain]  Cd Length: 133  Bit Score: 64.04  E-value: 3.72e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 150 SLKDFCNIIVKEVRKMTGFDRVMLYKFDeedngdviaedkieqlepYLGLRYPASDIplparnllsanwiRQIPDATSEP 229
Cdd:pfam01590   1 DLEEILQTILEELRELLGADRCALYLPD------------------ADGLEYLPPGA-------------RWLKAAGLEI 49

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 230 VDLVPSLHPETQQPLNLTLSSlrsASPCHLE---YLHNMGVGASLTISLIENKRLWGIIACHHRTPKYVPYElrkaCEFL 306
Cdd:pfam01590  50 PPGTGVTVLRTGRPLVVPDAA---GDPRFLDpllLLRNFGIRSLLAVPIIDDGELLGVLVLHHPRPPFTEEE----LELL 122
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 640-743 7.11e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 62.42  E-value: 7.11e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 640 LMQLFQNLIGNA----------IKFRGKATPTIHIAAQRQEEEWLFSVTDNGIGIDPRFSERIFVIFqrLHTRDEypGTG 709
Cdd:cd16918     1 LIQVFLNLVRNAaqalagsggeIILRTRTQRQVTLGHPRHRLALRVSVIDNGPGIPPDLQDTIFYPM--VSGREN--GTG 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1002987746 710 MGLAICKKIIECHRGRIWVESQLGKgAVFYFTIP 743
Cdd:cd16918    77 LGLAIAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 646-743 1.56e-11

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 61.74  E-value: 1.56e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 646 NLIGNAIKFRGKATPTIHIAAQRQEEEWLFSVTDNGIGIDPRFSERIFVIFQRL---HTRdEYPGTGMGLAICKKIIECH 722
Cdd:cd16925    11 NLLSNAFKFTPDGGRIRCILEKFRLNRFLLTVSDSGPGIPPNLREEIFERFRQGdgsSTR-AHGGTGLGLSIVKEFVELH 89

                          90       100
                  ....*....|....*....|.
gi 1002987746 723 RGRIWVESQLGKGAVFYFTIP 743
Cdd:cd16925    90 GGTVTVSDAPGGGALFQVELP 110
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
580-744 4.43e-11

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 65.72  E-value: 4.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 580 TLIDDVLAYSKVDM-QAVEFNTIDANLALEKALANLKGRIQESQAIITVDPLP---IVMADKTQLMQLFQNLIGNAIKFr 655
Cdd:PRK09470  290 SMINDLLVLSRNQQkNHLERETFKANSLWSEVLEDAKFEAEQMGKSLTVSAPPgpwPINGNPNALASALENIVRNALRY- 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 656 GKATPTIHIAAQRQEeewLF-SVTDNGIGIDPRFSERIFVIFQRLHT-RD-EYPGTGMGLAICKKIIECHRGRIWVE-SQ 731
Cdd:PRK09470  369 SHTKIEVAFSVDKDG---LTiTVDDDGPGVPEEEREQIFRPFYRVDEaRDrESGGTGLGLAIVENAIQQHRGWVKAEdSP 445

                         170
                  ....*....|...
gi 1002987746 732 LGkGAVFYFTIPL 744
Cdd:PRK09470  446 LG-GLRLTIWLPL 457
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
581-745 7.47e-11

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 65.85  E-value: 7.47e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 581 LIDDVLAYSKVDMQAVEfnTIDANLALEKALANLKGRIQESQAII---TVDPLpIVMADKTQLMQLFQNLIGNAIK-FRG 656
Cdd:PRK13837  502 IIDQILAFGRKGERNTK--PFDLSELVTEIAPLLRVSLPPGVELDfdqDQEPA-VVEGNPAELQQVLMNLCSNAAQaMDG 578

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 657 KATPTIHIAAQ-------------RQEEEWLFSVTDNGIGIDPRFSERIFVIFqrLHTRDEypGTGMGLAICKKIIECHR 723
Cdd:PRK13837  579 AGRVDISLSRAklrapkvlshgvlPPGRYVLLRVSDTGAGIDEAVLPHIFEPF--FTTRAG--GTGLGLATVHGIVSAHA 654

                         170       180
                  ....*....|....*....|..
gi 1002987746 724 GRIWVESQLGKGAVFYFTIPLG 745
Cdd:PRK13837  655 GYIDVQSTVGRGTRFDVYLPPS 676
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 636-743 9.22e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 59.47  E-value: 9.22e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 636 DKTQLMQLFQNLIGNAIK-FRGKATPTIHIAAQ---RQEEEWLFSVTDNGIGIDPRFSERIFvifqRLHTRDEYPGTGMG 711
Cdd:cd16944     1 DTTQISQVLTNILKNAAEaIEGRPSDVGEVRIRveaDQDGRIVLIVCDNGKGFPREMRHRAT----EPYVTTRPKGTGLG 76

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1002987746 712 LAICKKIIECHRGRIWVESQLGKGAVFYFTIP 743
Cdd:cd16944    77 LAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 640-743 2.10e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 58.35  E-value: 2.10e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 640 LMQLFQNLIGNAIKFRGKATPTIHIAAQRQEEEWLFSVTDNGIGIDPRFSERIFVIFQRLHTRDEYPGT--GMGLAICKK 717
Cdd:cd16953     1 LGQVLRNLIGNAISFSPPDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQhsGLGLSISRQ 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1002987746 718 IIECHRGRIWVESQ----LGKGAVFYFTIP 743
Cdd:cd16953    81 IIEAHGGISVAENHnqpgQVIGARFTVQLP 110
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 622-742 2.64e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 58.68  E-value: 2.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 622 QAIITVDPLPI-VMADKTQLMQLFQNLIGNAIKFrGKATPTIHIAAQRQEEEWLFSVTDNGIGIDPRFSERIFvifQRLH 700
Cdd:cd16947     2 QVEINIPDRPIyANANTEALQRILKNLISNAIKY-GSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVF---ERLY 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1002987746 701 TRDE-----YPGTGMGLAICKKIIECHRGRIWVESQLGKGAVFYFTI 742
Cdd:cd16947    78 TLEDsrnsaKQGNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTVTL 124
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
487-746 2.90e-10

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 61.56  E-value: 2.90e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 487 WKAVEINAALElRKAIVNIILKQADELARLARDLelsnaelkkfayvasHD--LQEpLNQVANYVQLLEMRYTEELDEDA 564
Cdd:COG4585    29 ARRAERAAELE-RELAARAEEAREEERRRIAREL---------------HDgvGQS-LSAIKLQLEAARRLLDADPEAAR 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 565 KEfitfavegVSLMQTLIDDVLAyskvDMQAVEFN---TIDANLALEKALANLKGRIQESQAI-----ITVDPLPIVMAD 636
Cdd:COG4585    92 EE--------LEEIRELAREALA----ELRRLVRGlrpPALDDLGLAAALEELAERLLRAAGIrveldVDGDPDRLPPEV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 637 KTQLMQLFQNLIGNAIKfRGKATpTIHIAAQRQEEEWLFSVTDNGIGIDPrfserifvifqrlhtrDEYPGTGMGLAICK 716
Cdd:COG4585   160 ELALYRIVQEALTNALK-HAGAT-RVTVTLEVDDGELTLTVRDDGVGFDP----------------EAAPGGGLGLRGMR 221

                         250       260       270
                  ....*....|....*....|....*....|
gi 1002987746 717 KIIECHRGRIWVESQLGKGAVFYFTIPLGG 746
Cdd:COG4585   222 ERAEALGGTLTIGSAPGGGTRVRATLPLAA 251
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
524-744 5.83e-10

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 63.21  E-value: 5.83e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746  524 NAELKKFAYVA--SHDLQEPLNQVANYVQLLEMRYTEEldEDAKEFITFAVEGVSLMQTLIDDVLAYSKVDM-------Q 594
Cdd:PRK09959   707 NATVAKSQFLAtmSHEIRTPISSIMGFLELLSGSGLSK--EQRVEAISLAYATGQSLLGLIGEILDVDKIESgnyqlqpQ 784

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746  595 AVEFNTIDAN-------LALEKALANLKGRIQESQAIITVDPlpivmadkTQLMQLFQNLIGNAIKFRGKA-----TPTI 662
Cdd:PRK09959   785 WVDIPTLVQNtchsfgaIAASKSIALSCSSTFPDHYLVKIDP--------QAFKQVLSNLLSNALKFTTEGavkitTSLG 856

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746  663 HIAAQRQEEEwlFSVTDNGIGIDPRFSERIFVIFQRLHTRDEYPGTGMGLAICKKIIECHRGRIWVESQLGKGAVFYFTI 742
Cdd:PRK09959   857 HIDDNHAVIK--MTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITI 934


                   ..
gi 1002987746  743 PL 744
Cdd:PRK09959   935 PV 936
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 636-743 7.36e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 56.91  E-value: 7.36e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 636 DKTQLMQLFQNLIGNAIKFRGKATPtIHIAAQRQEEEWLFSVTDNGIGIDPRFSERIF-VIFQRLHTRDEYPGTGMGLAI 714
Cdd:cd16948     2 DAKWLSFIIGQIVSNALKYSKQGGK-IEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFdKGFTGENGRNFQESTGMGLYL 80

                          90       100
                  ....*....|....*....|....*....
gi 1002987746 715 CKKIIECHRGRIWVESQLGKGAVFYFTIP 743
Cdd:cd16948    81 VKKLCDKLGHKIDVESEVGEGTTFTITFP 109
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 636-738 7.70e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 57.64  E-value: 7.70e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 636 DKTQLMQLFQNLIGNAIKFrgkATPTIHIAAQRQEEEWLFSVTDNGIGIDPRFSERIFVIFQRLHTRdeYPGTGMGLAIC 715
Cdd:cd16954    34 ERNDLMELLGNLLDNACKW---CLEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDEQ--RPGQGLGLAIA 108

                          90       100
                  ....*....|....*....|...
gi 1002987746 716 KKIIECHRGRIWVESQLGKGAVF 738
Cdd:cd16954   109 KEIVEQYGGELSLSDSPLGGARF 131
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 640-735 8.88e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 56.30  E-value: 8.88e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 640 LMQLFQNLIGNAIKFRGKAtptIHIAAQRQEEEWLFSVTDNGIGIDPRFSERIFVIFQRLHTRDEYPGTGMGLAICKKII 719
Cdd:cd16950     1 LKRVLSNLVDNALRYGGGW---VEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGTSGTGLGLAIVQRIS 77

                          90
                  ....*....|....*.
gi 1002987746 720 ECHRGRIWVESQLGKG 735
Cdd:cd16950    78 DAHGGSLTLANRAGGG 93
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 646-743 1.36e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 55.76  E-value: 1.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 646 NLIGNAIKF---RGKATPTIHIAAqRQEEEWL-FSVTDNGIGIDPRFSERIFvifQRLHTRDEYPGTGMGLAICKKIIEC 721
Cdd:cd16915     7 NLIDNALDAlaaTGAPNKQVEVFL-RDEGDDLvIEVRDTGPGIAPELRDKVF---ERGVSTKGQGERGIGLALVRQSVER 82

                          90       100
                  ....*....|....*....|..
gi 1002987746 722 HRGRIWVESQLGKGAVFYFTIP 743
Cdd:cd16915    83 LGGSITVESEPGGGTTFSIRIP 104
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
643-747 2.95e-09

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 60.03  E-value: 2.95e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 643 LFQNLIGNAIK--FRGKATP-TIHIAAQRQEEEWLFSVTDNGIGIDPrfsERIFVIFQRLHTRDEypGTGMGLAICKKII 719
Cdd:COG2972   340 ILQPLVENAIEhgIEPKEGGgTIRISIRKEGDRLVITVEDNGVGMPE---EKLEKLLEELSSKGE--GRGIGLRNVRERL 414

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1002987746 720 ECHRG---RIWVESQLGKGAVFYFTIPLGGN 747
Cdd:COG2972   415 KLYYGeeyGLEIESEPGEGTTVTIRIPLEEE 445
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 640-743 3.47e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 54.70  E-value: 3.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 640 LMQLFQNLIGNAIKFRGKATpTIHIAAQRQEEEWLFSVTDNGIGIDPRFSERIFVIFQRLHTRDEYPGTGMGLAICKKII 719
Cdd:cd16923     1 LQRVFSNLLSNAIKYSPENT-RIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRNTEGAGLGLSIAKAII 79

                          90       100
                  ....*....|....*....|....
gi 1002987746 720 ECHRGRIWVESQlGKGAVFYFTIP 743
Cdd:cd16923    80 ELHGGSASAEYD-DNHDLFKVRLP 102
envZ PRK09467
osmolarity sensor protein; Provisional
 535-726 6.53e-09

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 58.77  E-value: 6.53e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 535 SHDLQEPLNQV--ANyvqllEMRYTEelDEDAKEFITFAVEGvslMQTLIDDVLAYSKVDmQAVEFNTIDANLALEKALA 612
Cdd:PRK09467  237 SHDLRTPLTRIrlAT-----EMMSEE--DGYLAESINKDIEE---CNAIIEQFIDYLRTG-QEMPMEMADLNALLGEVIA 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 613 NLKGRIQESQAIITVDPLPIVM---ADKTQLMqlfqNLIGNAIKFrgkATPTIHIAAQRQEEEWLFSVTDNGIGIDPRFS 689
Cdd:PRK09467  306 AESGYEREIETALQPGPIEVPMnpiAIKRALA----NLVVNAARY---GNGWIKVSSGTEGKRAWFQVEDDGPGIPPEQL 378

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1002987746 690 ERIFVIFQRLHTRDEYPGTGMGLAICKKIIECHRGRI 726
Cdd:PRK09467  379 KHLFQPFTRGDSARGSSGTGLGLAIVKRIVDQHNGKV 415
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
631-743 5.70e-08

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 55.93  E-value: 5.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 631 PIVMADKTQLMQLFQNLIGNAIKFrgkaTP---TIHIAAQRQEEEWLFSVTDNGIGIDPRFSERIFVIFQRLHTRDEY-- 705
Cdd:PRK09835  367 CQVAGDPLMLRRAISNLLSNALRY----TPageAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRkg 442

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1002987746 706 PGTGMGLAICKKIIECHRGRIWVESQLgKGAVFYFTIP 743
Cdd:PRK09835  443 EGSGIGLAIVKSIVVAHKGTVAVTSDA-RGTRFVISLP 479
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
631-729 1.05e-07

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 54.59  E-value: 1.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 631 PIVMADKTQLMQLFQNLIGNAIKFRGKATpTIHIAAQRQEEEWLFSVTDNGIGIDPRFSERIFVIFQRLHTRdeYPGTGM 710
Cdd:PRK10755  239 ITVQGDATLLRLLLRNLVENAHRYSPEGS-TITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRMDSR--YGGIGL 315

                          90
                  ....*....|....*....
gi 1002987746 711 GLAICKKIIECHRGRIWVE 729
Cdd:PRK10755  316 GLSIVSRITQLHHGQFFLQ 334
HisKA pfam00512
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...
 526-592 1.90e-07

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.


Pssm-ID: 459839 [Multi-domain]  Cd Length: 66  Bit Score: 48.75  E-value: 1.90e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002987746 526 ELKKFAYVASHDLQEPLNQVANYVQLLEMrytEELDEDAKEFITFAVEGVSLMQTLIDDVLAYSKVD 592
Cdd:pfam00512   1 AKSEFLANLSHELRTPLTAIRGYLELLRD---EKLDEEQREYLETILRSAERLLRLINDLLDLSRIE 64
HisKA cd00082
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...
 524-590 2.46e-07

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.


Pssm-ID: 119399 [Multi-domain]  Cd Length: 65  Bit Score: 48.36  E-value: 2.46e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002987746 524 NAELKKFAYVASHDLQEPLNQVANYVQLLEMryTEELDEDAKEFITFAVEGVSLMQTLIDDVLAYSK 590
Cdd:cd00082     1 LQAKGEFLANVSHELRTPLTAIRGALELLEE--ELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 646-751 3.46e-07

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 53.76  E-value: 3.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 646 NLIGNAIK-FRGKATPTIHIAAQRQEEEWLFSVTDNGIGIDPRFSERIFVifQRLHTRDEypGTGMGLAICKKIIECHRG 724
Cdd:PRK11086  440 NLIENALEaVGGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFD--KGYSTKGS--NRGVGLYLVKQSVENLGG 515

                          90       100
                  ....*....|....*....|....*..
gi 1002987746 725 RIWVESQLGKGAVFYFTIPLGGNERER 751
Cdd:PRK11086  516 SIAVESEPGVGTQFFVQIPWDGERSNR 542
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
643-744 5.47e-07

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 52.56  E-value: 5.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 643 LFQNLIGNAIK--FRGKATP-TIHIAAQRQEEEWLFSVTDNGIGIDPRFSErifvifqrlhtrdeyPGTGMGLAICKKII 719
Cdd:COG3275   257 LLQPLVENAIKhgISSKEGGgTISISIEVEGDRLVIEVENNGVGIQPKKKK---------------KGSGIGLKNVRERL 321

                          90       100
                  ....*....|....*....|....*...
gi 1002987746 720 E---CHRGRIWVESQLGKGAVFYFTIPL 744
Cdd:COG3275   322 EllyGDKYSLEIESTDGGGTKVTLKIPL 349
HisKA smart00388
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...
 526-592 8.52e-07

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.


Pssm-ID: 214644 [Multi-domain]  Cd Length: 66  Bit Score: 46.79  E-value: 8.52e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1002987746  526 ELKKFAYVASHDLQEPLNQVANYVQLLEMrytEELDEDAKEFITFAVEGVSLMQTLIDDVLAYSKVD 592
Cdd:smart00388   1 AKREFLANLSHELRTPLTAIRGYLELLLD---TELSEEQREYLETILREAERLLRLINDLLDLSRIE 64
glnL PRK11073
nitrogen regulation protein NR(II);
496-744 1.05e-06

nitrogen regulation protein NR(II);


Pssm-ID: 182947 [Multi-domain]  Cd Length: 348  Bit Score: 51.62  E-value: 1.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 496 LELRKA-----IVNIILKQADELArlARDLELSNAelkkfayvasHDLQEPLNQVANYVQLLEmrytEEL-DEDAKEFIT 569
Cdd:PRK11073  106 LEMAPMdnqrrLSQEQLQHAQQVA--ARDLVRGLA----------HEIKNPLGGLRGAAQLLS----KALpDPALTEYTK 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 570 FAVEGVSLMQTLIDDVLAYSKVDMQAVEfntiDANLALEK--ALANLkgriqESQAIITV----DP-LPIVMADKTQLMQ 642
Cdd:PRK11073  170 VIIEQADRLRNLVDRLLGPQRPGTHVTE----SIHKVAERvvQLVSL-----ELPDNVRLirdyDPsLPELAHDPDQIEQ 240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 643 LFQNLIGNA----------IKFRGKATPTIHIAAQRQEEEWLFSVTDNGIGIDPRFSERIFvifqrlhtrdeYP------ 706
Cdd:PRK11073  241 VLLNIVRNAlqalgpeggtITLRTRTAFQLTLHGERYRLAARIDIEDNGPGIPPHLQDTLF-----------YPmvsgre 309

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1002987746 707 -GTGMGLAICKKIIECHRGRIWVESQLGKGAvfyFTIPL 744
Cdd:PRK11073  310 gGTGLGLSIARNLIDQHSGKIEFTSWPGHTE---FSVYL 345
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 674-743 1.06e-06

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 48.14  E-value: 1.06e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 674 LFSVTDNGIGIDPRFSERIFVIFqrLHTRDEYPGTGMGLAICKKIIECHRGRIWVESQLGKGAVFYFTIP 743
Cdd:cd16919    49 CLEVSDTGSGMPAEVLRRAFEPF--FTTKEVGKGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 640-726 5.99e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 45.53  E-value: 5.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 640 LMQLFQNLIGNAIKFrgkaTP---TIHIAAQRQEEEWLFSVTDNGIGIDPRFSERIFVIF---QRLHTRDEypGTGMGLA 713
Cdd:cd16945     5 LRQAINNLLDNAIDF----SPeggLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFyslPRPHSGQK--STGLGLA 78

                          90
                  ....*....|...
gi 1002987746 714 ICKKIIECHRGRI 726
Cdd:cd16945    79 FVQEVAQLHGGRI 91
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 552-744 1.05e-05

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 48.75  E-value: 1.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 552 LEMRYTEelDEDAKEFITFA---VEGVSLMQTLIDDVLAYSKVDMQAVefntidanlaLEKALANLKGRIQESQAIITVD 628
Cdd:COG3920   319 LQARRAD--DPEAREALEESqnrIQALALVHELLYQSEDWEGVDLRDY----------LRELLEPLRDSYGGRGIRIELD 386

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 629 PLPIVM-ADKTQLMQLFQN-LIGNAIK--FRGKATPTIHIAAQRQEEEWLFSVTDNGIGIDPRFSERifvifqrlhtrde 704
Cdd:COG3920   387 GPDVELpADAAVPLGLILNeLVTNALKhaFLSGEGGRIRVSWRREDGRLRLTVSDNGVGLPEDVDPP------------- 453

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1002987746 705 yPGTGMGLAICKKIIECHRGRIwvESQLGKGAVFYFTIPL 744
Cdd:COG3920   454 -ARKGLGLRLIRALVRQLGGTL--ELDRPEGTRVRITFPL 490
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
625-736 2.22e-05

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 47.71  E-value: 2.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 625 ITVDPLPIVM--ADKTQLMQLFQNLIGNAIKFrgkATPTIHIAAQRQEEEWLFSVTDNGIGIDPRFSERIFVIFQRLHT- 701
Cdd:PRK10815  362 ITLDISPEITfvGEKNDFMEVMGNVLDNACKY---CLEFVEISARQTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTl 438

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1002987746 702 RdeyPGTGMGLAICKKIIECHRGRIWV-ESQLGkGA 736
Cdd:PRK10815  439 R---PGQGLGLSVAREITEQYEGKISAgDSPLG-GA 470
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 636-736 6.31e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 42.83  E-value: 6.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 636 DKTQLMQLFQNLIGNAIKFrGKATPTIHIAAQRQEEEWLFSVTDNGIGidprFSERIFVIFQRLHTRDEYPGT-----GM 710
Cdd:cd16975     1 DTLLLSRALINIISNACQY-APEGGTVSISIYDEEEYLYFEIWDNGHG----FSEQDLKKALELFYRDDTSRRsgghyGM 75

                          90       100
                  ....*....|....*....|....*.
gi 1002987746 711 GLAICKKIIECHRGRIWVESQLGKGA 736
Cdd:cd16975    76 GLYIAKNLVEKHGGSLIIENSQKGGA 101
PRK10337 PRK10337
sensor protein QseC; Provisional
 528-722 9.03e-05

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 45.80  E-value: 9.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 528 KKFAYVASHDLQEPLnqVANYVQllemryTE--ELDEDAKEFITFAV----EGVSLMQTLIDDVLAYSKVD-------MQ 594
Cdd:PRK10337  238 RRFTSDAAHELRSPL--AALKVQ------TEvaQLSDDDPQARKKALlqlhAGIDRATRLVDQLLTLSRLDsldnlqdVA 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 595 AVEFNTIdanlaLEKALANLKGRIQesQAIITV----DPLPIVMADKTQLMQLF-QNLIGNAIKF--RGkATPTIHIAAQ 667
Cdd:PRK10337  310 EIPLEDL-----LQSAVMDIYHTAQ--QAGIDVrltlNAHPVIRTGQPLLLSLLvRNLLDNAIRYspQG-SVVDVTLNAR 381

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1002987746 668 RqeeewlFSVTDNGIGIDPRFSERIFVIFQRLHTRDEyPGTGMGLAICKKIIECH 722
Cdd:PRK10337  382 N------FTVRDNGPGVTPEALARIGERFYRPPGQEA-TGSGLGLSIVRRIAKLH 429
PRK10935 PRK10935
nitrate/nitrite two-component system sensor histidine kinase NarQ;
600-686 1.42e-04

nitrate/nitrite two-component system sensor histidine kinase NarQ;


Pssm-ID: 236800 [Multi-domain]  Cd Length: 565  Bit Score: 45.23  E-value: 1.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 600 TI-DANL--ALEKALANLKGRiqeSQAIITVD-PLPIVMADKTQLMQLFQnLIG----NAIKfRGKATpTIHIAAQRQEE 671
Cdd:PRK10935  428 TIqEANLgsALEEMLDQLRNQ---TDAKITLDcRLPSQALDAQQQVHLLQ-IIReatlNAIK-HANAS-EIAVSCVTNPD 501

                          90
                  ....*....|....*.
gi 1002987746 672 EW-LFSVTDNGIGIDP 686
Cdd:PRK10935  502 GEhTVSIRDDGIGIGE 517
CheA COG0643
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
655-744 2.33e-04

Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];


Pssm-ID: 440408 [Multi-domain]  Cd Length: 563  Bit Score: 44.40  E-value: 2.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 655 RGK-ATPTIHIAAQRQEEEWLFSVTDNGIGIDPrfsERIF--VIFQRLHTRDEY--------------PG--T------- 708
Cdd:COG0643   303 AGKpETGTITLSAYHEGGRVVIEVSDDGRGLDL---EKIRakAIEKGLITAEEAaalsdeellelifaPGfsTaeevtdl 379

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1002987746 709 ---GMGLAICKKIIECHRGRIWVESQLGKGAVFYFTIPL 744
Cdd:COG0643   380 sgrGVGMDVVKTNIEALGGTIEIESEPGKGTTFTLRLPL 418
HATPase_ETR2_ERS2-EIN4-like cd16938
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related ...
 630-738 2.42e-04

Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related domains; This family includes the histidine kinase-like ATPase domains (HATPase) of three out of the five receptors that recognize the plant hormone ethylene in Arabidopsis thaliana. These three proteins have been classified as belonging to subfamily 2: ETR2, ERS2, and EIN4. They lack most of the motifs characteristic of histidine kinases, and EIN4 is the only one in this group containing the conserved histidine that is phosphorylated in two-component and phosphorelay systems. This family also includes the HATPase domains of Escherichia coli RcsD phosphotransferase which is a component of the Rcs-signaling system, a complex multistep phosphorelay involving five proteins, and is involved in many transcriptional networks such as cell division, biofilm formation, and virulence, among others. Also included is Schizosaccharomyces pombe Mak3 (Phk1) which participates in a multi-step two-component related system which regulates H2O2-induced activation of the Sty1 stress-activated protein kinase pathway. Most proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a GAF sensor domain; most are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340415 [Multi-domain]  Cd Length: 133  Bit Score: 41.67  E-value: 2.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 630 LP-IVMADKTQLMQLFQNLIGNAIK---------FRGKATPTIHIAAQRQEEEWLFSVTDNGIGIdpRFSERI------- 692
Cdd:cd16938     1 LPdVVVGDERRVFQVLLHMLGNLLKmrngggnitFRVFLEGGSEDRSDRDWGPWRPSMSDESVEI--RFEVEIndsgsps 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1002987746 693 ---FVIFQRLHTRD--EYPGTGMGLAICKKIIECHRGRIWVESQLGKGAVF 738
Cdd:cd16938    79 iesASMRNSLNRRYnlSELGEHLSFSICKQLVQLMGGNIWIVPGSGLGTTM 129
HATPase_CheA-like cd16916
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ...
 640-743 3.36e-04

Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.


Pssm-ID: 340393 [Multi-domain]  Cd Length: 178  Bit Score: 42.18  E-value: 3.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002987746 640 LMQLFQNLIGNAIKF------RGK-ATPTIHIAAQRQEEEWLFSVTDNGIGIDPrfsERIF--VIFQRLHTRDEYP---- 706
Cdd:cd16916    43 LTHLLRNAVDHGIEApeerlaAGKpPEGTITLRAEHQGNQVVIEVSDDGRGIDR---EKIRekAIERGLITADEAAtlsd 119

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1002987746 707 ----------------------GTGMGLAICKKIIECHRGRIWVESQLGKGAVFYFTIP 743
Cdd:cd16916   120 devlnlifapgfstaeqvtdvsGRGVGMDVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
647-718 3.72e-03

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 37.97  E-value: 3.72e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1002987746 647 LIGNAIK--FRGKATPTIHIAAQRQEEEWLFSVTDNGIGIDPRfserifvifQRLHTRDEYPGTGMGLAICKKI 718
Cdd:COG2172    42 AVTNAVRhaYGGDPDGPVEVELELDPDGLEIEVRDEGPGFDPE---------DLPDPYSTLAEGGRGLFLIRRL 106
HATPase_YpdA-like cd16955
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 643-712 4.72e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340431 [Multi-domain]  Cd Length: 102  Bit Score: 37.44  E-value: 4.72e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1002987746 643 LFQNLIGNAIKF-----RGKATPTIHIAaQRQEEEWLFSVTDNGIGIDPRFSERIfvifqrlhTRDEYPGTGMGL 712
Cdd:cd16955     5 MIQPLVENAIVHgiqekKGKGVVKISVK-KQLKNRLHIAVEDNGIGISPKVIERV--------EQDEMPGNKIGL 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH