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Conserved domains on  [gi|1002972057|ref|WP_061421395|]
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MULTISPECIES: Stealth CR1 domain-containing protein [Streptococcus]

Protein Classification

Stealth_CR1 and Stealth_CR2 domain-containing protein( domain architecture ID 11246918)

protein containing domains Stealth_CR1, Stealth_CR2, and Stealth_CR3

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Stealth_CR2 pfam11380
Stealth protein CR2, conserved region 2; Stealth_CR2 is the second of several highly conserved ...
 42-147 1.80e-60

Stealth protein CR2, conserved region 2; Stealth_CR2 is the second of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR2 carries a well-conserved NDD sequence-motif. The domain is found in tandem with CR1, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


:

Pssm-ID: 463267  Cd Length: 108  Bit Score: 188.83  E-value: 1.80e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002972057  42 YRDWGTFKYWFRGVEKFAPWVNKVYLVTDQQKPSWLDINSEKLVLVDHTEIICNDY-LPVFSANPIESNIHRIPGLSEHF 120
Cdd:pfam11380   2 FRDRDELRYSLRSVEKYAPWVRKIYIVTDGQIPSWLNTSHPKIRIVDHKDIFPNEShLPTFNSHAIESNLHRIPGLSEHF 81

                          90       100
                  ....*....|....*....|....*..
gi 1002972057 121 VFFNDDMYLTAPVEPTDFFSEDGLPKY 147
Cdd:pfam11380  82 LYFNDDMFLGRPVKPEDFFTPDGLPKD 108
Stealth_CR1 pfam17101
Stealth protein CR1, conserved region 1; Stealth_C1 is the first of several highly conserved ...
 3-30 4.89e-09

Stealth protein CR1, conserved region 1; Stealth_C1 is the first of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR1 carries a well-conserved IDVVYT sequence-motif. The domain is found in tandem with CR2, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


:

Pssm-ID: 465346  Cd Length: 29  Bit Score: 50.93  E-value: 4.89e-09
                          10        20
                  ....*....|....*....|....*...
gi 1002972057   3 KIDFVVTWVDGGDPIWQAKKAKYSGAVD 30
Cdd:pfam17101   2 PIDVVYTWVNGSDPEWQAKKAKYLGKLG 29
Stealth_CR3 pfam17102
Stealth protein CR3, conserved region 3; Stealth_CR3 is the third of several highly conserved ...
 215-263 1.72e-08

Stealth protein CR3, conserved region 3; Stealth_CR3 is the third of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. The domain is found in tandem with CR1, CR2 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


:

Pssm-ID: 465347  Cd Length: 49  Bit Score: 49.83  E-value: 1.72e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1002972057 215 SHLPYPLLRSTMNLVWEKEKAVLERTSASRFRNPSDTNVWLFKYWQIAS 263
Cdd:pfam17102   1 AHTPHPLRRSVLEEIEERFPEEFARTASHRFRSPDDLSMAFSYHHYYAE 49
 
Name Accession Description Interval E-value
Stealth_CR2 pfam11380
Stealth protein CR2, conserved region 2; Stealth_CR2 is the second of several highly conserved ...
 42-147 1.80e-60

Stealth protein CR2, conserved region 2; Stealth_CR2 is the second of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR2 carries a well-conserved NDD sequence-motif. The domain is found in tandem with CR1, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


Pssm-ID: 463267  Cd Length: 108  Bit Score: 188.83  E-value: 1.80e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002972057  42 YRDWGTFKYWFRGVEKFAPWVNKVYLVTDQQKPSWLDINSEKLVLVDHTEIICNDY-LPVFSANPIESNIHRIPGLSEHF 120
Cdd:pfam11380   2 FRDRDELRYSLRSVEKYAPWVRKIYIVTDGQIPSWLNTSHPKIRIVDHKDIFPNEShLPTFNSHAIESNLHRIPGLSEHF 81

                          90       100
                  ....*....|....*....|....*..
gi 1002972057 121 VFFNDDMYLTAPVEPTDFFSEDGLPKY 147
Cdd:pfam11380  82 LYFNDDMFLGRPVKPEDFFTPDGLPKD 108
Stealth_CR1 pfam17101
Stealth protein CR1, conserved region 1; Stealth_C1 is the first of several highly conserved ...
 3-30 4.89e-09

Stealth protein CR1, conserved region 1; Stealth_C1 is the first of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR1 carries a well-conserved IDVVYT sequence-motif. The domain is found in tandem with CR2, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


Pssm-ID: 465346  Cd Length: 29  Bit Score: 50.93  E-value: 4.89e-09
                          10        20
                  ....*....|....*....|....*...
gi 1002972057   3 KIDFVVTWVDGGDPIWQAKKAKYSGAVD 30
Cdd:pfam17101   2 PIDVVYTWVNGSDPEWQAKKAKYLGKLG 29
Stealth_CR3 pfam17102
Stealth protein CR3, conserved region 3; Stealth_CR3 is the third of several highly conserved ...
 215-263 1.72e-08

Stealth protein CR3, conserved region 3; Stealth_CR3 is the third of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. The domain is found in tandem with CR1, CR2 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


Pssm-ID: 465347  Cd Length: 49  Bit Score: 49.83  E-value: 1.72e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1002972057 215 SHLPYPLLRSTMNLVWEKEKAVLERTSASRFRNPSDTNVWLFKYWQIAS 263
Cdd:pfam17102   1 AHTPHPLRRSVLEEIEERFPEEFARTASHRFRSPDDLSMAFSYHHYYAE 49
 
Name Accession Description Interval E-value
Stealth_CR2 pfam11380
Stealth protein CR2, conserved region 2; Stealth_CR2 is the second of several highly conserved ...
 42-147 1.80e-60

Stealth protein CR2, conserved region 2; Stealth_CR2 is the second of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR2 carries a well-conserved NDD sequence-motif. The domain is found in tandem with CR1, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


Pssm-ID: 463267  Cd Length: 108  Bit Score: 188.83  E-value: 1.80e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1002972057  42 YRDWGTFKYWFRGVEKFAPWVNKVYLVTDQQKPSWLDINSEKLVLVDHTEIICNDY-LPVFSANPIESNIHRIPGLSEHF 120
Cdd:pfam11380   2 FRDRDELRYSLRSVEKYAPWVRKIYIVTDGQIPSWLNTSHPKIRIVDHKDIFPNEShLPTFNSHAIESNLHRIPGLSEHF 81

                          90       100
                  ....*....|....*....|....*..
gi 1002972057 121 VFFNDDMYLTAPVEPTDFFSEDGLPKY 147
Cdd:pfam11380  82 LYFNDDMFLGRPVKPEDFFTPDGLPKD 108
Stealth_CR1 pfam17101
Stealth protein CR1, conserved region 1; Stealth_C1 is the first of several highly conserved ...
 3-30 4.89e-09

Stealth protein CR1, conserved region 1; Stealth_C1 is the first of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR1 carries a well-conserved IDVVYT sequence-motif. The domain is found in tandem with CR2, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


Pssm-ID: 465346  Cd Length: 29  Bit Score: 50.93  E-value: 4.89e-09
                          10        20
                  ....*....|....*....|....*...
gi 1002972057   3 KIDFVVTWVDGGDPIWQAKKAKYSGAVD 30
Cdd:pfam17101   2 PIDVVYTWVNGSDPEWQAKKAKYLGKLG 29
Stealth_CR3 pfam17102
Stealth protein CR3, conserved region 3; Stealth_CR3 is the third of several highly conserved ...
 215-263 1.72e-08

Stealth protein CR3, conserved region 3; Stealth_CR3 is the third of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. The domain is found in tandem with CR1, CR2 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


Pssm-ID: 465347  Cd Length: 49  Bit Score: 49.83  E-value: 1.72e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1002972057 215 SHLPYPLLRSTMNLVWEKEKAVLERTSASRFRNPSDTNVWLFKYWQIAS 263
Cdd:pfam17102   1 AHTPHPLRRSVLEEIEERFPEEFARTASHRFRSPDDLSMAFSYHHYYAE 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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