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Conserved domains on  [gi|981233381|ref|WP_059453411|]
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adenylosuccinate synthase [Burkholderia vietnamiensis]

Protein Classification

adenylosuccinate synthetase( domain architecture ID 10011626)

GTP-dependent adenylosuccinate synthetase catalyzes the formation of adenylosuccinate from L-aspartate and IMP, the first step in the de novo biosynthesis of AMP

CATH:  3.40.440.10|3.90.170.10|1.10.300.10
EC:  6.3.4.4
Gene Ontology:  GO:0044208|GO:0004019|GO:0005525|GO:0003688|GO:0000287
PubMed:  8244965|11916378|6347525|10218106
SCOP:  4003995

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK01117 PRK01117
adenylosuccinate synthetase; Provisional
 1-427 0e+00

adenylosuccinate synthetase; Provisional


:

Pssm-ID: 234904  Cd Length: 430  Bit Score: 657.50  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381   1 MPNVVVVGAQWGDEGKGRVVDWLAAQADLVARYNGGHNAGHTLVVGGKTYKLALLPSGIVR-GKRGVIGNGVALDPEALL 79
Cdd:PRK01117   1 MKNVVVVGTQWGDEGKGKIVDLLSERADVVVRFQGGHNAGHTLVIDGKKYKLHLIPSGILRpGKTCVIGNGVVLDPEALL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381  80 AEIARMAELGVSVtPDNLSIAENATLVLPIHRAIDEAQERLRRE-PIGTTLRGIGPAYEDKVGRRALRVADLAEPDRLAD 158
Cdd:PRK01117  81 KEIDELEARGVDV-RERLRISERAHLILPYHRALDKAREKARGKkKIGTTGRGIGPAYEDKVARRGIRVGDLLDPETFAE 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 159 KLDVLVDHHNAWFRGL-GLAPSSRDVMLATLVELAPKILPFVRPVWAELNDAHARGERILFEGSQAVMLDIDWGTYPFVT 237
Cdd:PRK01117 160 KLEENLEYKNFLLTKYyGAEAVDFEEILDEYLEYAERLKPYVTDTSLLLNDALKAGKRVLFEGAQGTLLDIDHGTYPFVT 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 238 -----------------SsgtiasaaaagtglgasKLGHVLGVTKAYATRVGGGPFLTELGDATGERLRTRGREFGVNTG 300
Cdd:PRK01117 240 ssnttaggaatgsgvgpT-----------------KIDYVLGIAKAYTTRVGSGPFPTELFDEVGEHLRERGHEFGTTTG 302

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 301 RPRRCGWLDAAQLRQAVCVSGIDSLALTKLDVLDGFESIALCVGYELDGARIAHLPTSLDAQLRVRPIYEEFAGWDGTVK 380
Cdd:PRK01117 303 RPRRCGWFDAVALRYAVRVNGLTGLALTKLDVLDGLEEIKICVAYELDGKRIDYFPASLEDLARCEPIYEELPGWSESTT 382

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 981233381 381 GVRERAALPRAAQAFIERVEAVAGAPVSMITTGAERDDTIVLSNPFD 427
Cdd:PRK01117 383 GVRSFDDLPENARKYIKRIEELTGVPISIISTGPDRDQTIILRDPFA 429
 
Name Accession Description Interval E-value
PRK01117 PRK01117
adenylosuccinate synthetase; Provisional
 1-427 0e+00

adenylosuccinate synthetase; Provisional


Pssm-ID: 234904  Cd Length: 430  Bit Score: 657.50  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381   1 MPNVVVVGAQWGDEGKGRVVDWLAAQADLVARYNGGHNAGHTLVVGGKTYKLALLPSGIVR-GKRGVIGNGVALDPEALL 79
Cdd:PRK01117   1 MKNVVVVGTQWGDEGKGKIVDLLSERADVVVRFQGGHNAGHTLVIDGKKYKLHLIPSGILRpGKTCVIGNGVVLDPEALL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381  80 AEIARMAELGVSVtPDNLSIAENATLVLPIHRAIDEAQERLRRE-PIGTTLRGIGPAYEDKVGRRALRVADLAEPDRLAD 158
Cdd:PRK01117  81 KEIDELEARGVDV-RERLRISERAHLILPYHRALDKAREKARGKkKIGTTGRGIGPAYEDKVARRGIRVGDLLDPETFAE 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 159 KLDVLVDHHNAWFRGL-GLAPSSRDVMLATLVELAPKILPFVRPVWAELNDAHARGERILFEGSQAVMLDIDWGTYPFVT 237
Cdd:PRK01117 160 KLEENLEYKNFLLTKYyGAEAVDFEEILDEYLEYAERLKPYVTDTSLLLNDALKAGKRVLFEGAQGTLLDIDHGTYPFVT 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 238 -----------------SsgtiasaaaagtglgasKLGHVLGVTKAYATRVGGGPFLTELGDATGERLRTRGREFGVNTG 300
Cdd:PRK01117 240 ssnttaggaatgsgvgpT-----------------KIDYVLGIAKAYTTRVGSGPFPTELFDEVGEHLRERGHEFGTTTG 302

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 301 RPRRCGWLDAAQLRQAVCVSGIDSLALTKLDVLDGFESIALCVGYELDGARIAHLPTSLDAQLRVRPIYEEFAGWDGTVK 380
Cdd:PRK01117 303 RPRRCGWFDAVALRYAVRVNGLTGLALTKLDVLDGLEEIKICVAYELDGKRIDYFPASLEDLARCEPIYEELPGWSESTT 382

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 981233381 381 GVRERAALPRAAQAFIERVEAVAGAPVSMITTGAERDDTIVLSNPFD 427
Cdd:PRK01117 383 GVRSFDDLPENARKYIKRIEELTGVPISIISTGPDRDQTIILRDPFA 429
PurA COG0104
Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is ...
 3-422 0e+00

Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439874  Cd Length: 423  Bit Score: 632.82  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381   3 NVVVVGAQWGDEGKGRVVDWLAAQADLVARYNGGHNAGHTLVVGGKTYKLALLPSGIVR-GKRGVIGNGVALDPEALLAE 81
Cdd:COG0104    1 NVVVVGAQWGDEGKGKIVDLLAERADVVVRFQGGNNAGHTVVVGGKKFKLHLIPSGILRpGKTCVIGNGVVLDPEALLEE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381  82 IARMAELGVSVTpDNLSIAENATLVLPIHRAIDEAQERLR-REPIGTTLRGIGPAYEDKVGRRALRVADLAEPDRLADKL 160
Cdd:COG0104   81 IDGLEARGVDVR-SRLRISERAHLILPYHRALDKAREEARgKKKIGTTGRGIGPAYEDKVARRGIRVGDLLDPEVLREKL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 161 DVLVDHHNAWFRGL-GLAPSSRDVMLATLVELAPKILPFVRPVWAELNDAHARGERILFEGSQAVMLDIDWGTYPFVT-- 237
Cdd:COG0104  160 EELLEYKNFLLEKLyGAEPLDFEELLEEYLEYAERLKPYVADTSELLNEALKAGKKVLFEGAQGTLLDIDHGTYPYVTss 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 238 ---------------SsgtiasaaaagtglgasKLGHVLGVTKAYATRVGGGPFLTELGDATGERLRTRGREFGVNTGRP 302
Cdd:COG0104  240 nttaggactgsgvgpT-----------------KIDRVIGVVKAYTTRVGEGPFPTELFDETGERLRERGHEFGTTTGRP 302

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 303 RRCGWLDAAQLRQAVCVSGIDSLALTKLDVLDGFESIALCVGYELDGARIAHLPTSLDAQLRVRPIYEEFAGWDGTVKGV 382
Cdd:COG0104  303 RRCGWLDAVALRYAVRINGLTGLALTKLDVLDGLDEIKVCVAYELDGERIDEFPASLEDLARCEPVYEELPGWKEDISGI 382

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 981233381 383 RERAALPRAAQAFIERVEAVAGAPVSMITTGAERDDTIVL 422
Cdd:COG0104  383 RSFEDLPENARAYVERIEELLGVPISIVSVGPDREQTIVR 422
Adenylsucc_synt pfam00709
Adenylosuccinate synthetase;
5-420 0e+00

Adenylosuccinate synthetase;


Pssm-ID: 459912  Cd Length: 417  Bit Score: 618.60  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381    5 VVVGAQWGDEGKGRVVDWLAAQADLVARYNGGHNAGHTLVVGGKTYKLALLPSGIVR-GKRGVIGNGVALDPEALLAEIA 83
Cdd:pfam00709   1 VVVGAQWGDEGKGKIVDLLAEDADVVVRFQGGNNAGHTVVVDGKKYKLHLLPSGILNpGKTNVIGNGVVIDPPALLEEIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381   84 RMAELGVSVtPDNLSIAENATLVLPIHRAIDEAQERLRRE-PIGTTLRGIGPAYEDKVGRRALRVADLAEPDRLADKLDV 162
Cdd:pfam00709  81 ELEERGIDV-PDRLFISDRAHLILPYHKALDGLREEARGKkKIGTTGRGIGPAYSDKAARRGIRVGDLLDPEVFREKLEA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381  163 LVDHHNAWFRGLGLAPSSRDVMLATLVELAPKILPFVRPVWAELNDAHARGERILFEGSQAVMLDIDWGTYPFVTSSGTI 242
Cdd:pfam00709 160 LLELKNKLLEKLYGEPLDVEEELEELLEYAERLKPYVVDTSYFLNKALKEGKKILFEGAQGTLLDIDHGTYPYVTSSNTT 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381  243 ASAAAAGTGLGASKLGHVLGVTKAYATRVGGGPFLTELGDATGERLRTRGREFGVNTGRPRRCGWLDAAQLRQAVCVSGI 322
Cdd:pfam00709 240 AGGACTGLGIGPTKIDEVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGATTGRPRRCGWLDLVALRYAVRINGV 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381  323 DSLALTKLDVLDGFESIALCVGYELDGARIAHLPTSLDAQLRVRPIYEEFAGWDGTVKGVRERAALPRAAQAFIERVEAV 402
Cdd:pfam00709 320 TGLALTKLDVLDGLDEIKVCVAYELDGKRIDYFPADLEDLEKVEPVYETLPGWKEDISGVRSFEDLPENARKYVEFIEEL 399

                         410
                  ....*....|....*...
gi 981233381  403 AGAPVSMITTGAERDDTI 420
Cdd:pfam00709 400 LGVPIKIISVGPDREQTI 417
Adenylsucc_synt smart00788
Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine ...
 3-421 0e+00

Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine biosynthesis, by catalyzing the GTP-dependent conversion of IMP and aspartic acid to AMP. Adenylosuccinate synthetase has been characterized from various sources ranging from Escherichia coli (gene purA) to vertebrate tissues. In vertebrates, two isozymes are present - one involved in purine biosynthesis and the other in the purine nucleotide cycle. The crystal structure of adenylosuccinate synthetase from E. coli reveals that the dominant structural element of each monomer of the homodimer is a central beta-sheet of 10 strands. The first nine strands of the sheet are mutually parallel with right-handed crossover connections between the strands. The 10th strand is antiparallel with respect to the first nine strands. In addition, the enzyme has two antiparallel beta-sheets, comprised of two strands and three strands each, 11 alpha-helices and two short 3/10-helices. Further, it has been suggested that the similarities in the GTP-binding domains of the synthetase and the p21ras protein are an example of convergent evolution of two distinct families of GTP-binding proteins. Structures of adenylosuccinate synthetase from Triticum aestivum and Arabidopsis thaliana when compared with the known structures from E. coli reveals that the overall fold is very similar to that of the E. coli protein.


Pssm-ID: 197875  Cd Length: 417  Bit Score: 612.56  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381     3 NVVVVGAQWGDEGKGRVVDWLAAQADLVARYNGGHNAGHTLVVGGKTYKLALLPSGIVR-GKRGVIGNGVALDPEALLAE 81
Cdd:smart00788   1 VVVVVGAQWGDEGKGKIVDYLAEKADVVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNpNKKNVIGNGVVIDPEALFKE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381    82 IARMAELGVSVTpDNLSIAENATLVLPIHRAIDEAQERLRrepIGTTLRGIGPAYEDKVGRRALRVADLAEPDRLADKLD 161
Cdd:smart00788  81 IEELEAKGVDVK-DRLFISDRAHLILPYHIALDKAREKAR---IGTTGRGIGPAYEDKVARRGIRVGDLFDEEVLREKLE 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381   162 VLVDHHNAWFRGL-GLAPSSRDVMLATLVELAPKILPFVRPVWAELNDAHARGERILFEGSQAVMLDIDWGTYPFVTSSG 240
Cdd:smart00788 157 ELLDYKNFLLKKLyGAEPVDVEEILEELLEYAERLRPYVTDVSELLNEALKAGKKVLFEGAQGTLLDIDHGTYPYVTSSN 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381   241 TIASAAAAGTGLGASKLGHVLGVTKAYATRVGGGPFLTELGDATGERLRTRGREFGVNTGRPRRCGWLDAAQLRQAVCVS 320
Cdd:smart00788 237 TTAGGAATGAGIGPTRIDRVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGTTTGRPRRCGWFDAVLLRYAVRIN 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381   321 GIDSLALTKLDVLDGFESIALCVGYELDGARIAHLPTSLDAQLRVRPIYEEFAGWDGTVKGVRERAALPRAAQAFIERVE 400
Cdd:smart00788 317 GITGLALTKLDVLDGLDEIKVCVAYKLDGKIIDYFPADLEDLERCEPIYEELPGWKEDTTGVRSYEDLPENAKKYIERIE 396

                          410       420
                   ....*....|....*....|.
gi 981233381   401 AVAGAPVSMITTGAERDDTIV 421
Cdd:smart00788 397 ELVGVPVSIISTGPDREQTIV 417
purA TIGR00184
adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, ...
 5-427 1.03e-154

adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272949  Cd Length: 425  Bit Score: 444.30  E-value: 1.03e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381    5 VVVGAQWGDEGKGRVVDWLAAQADLVARYNGGHNAGHTLVVGGKTYKLALLPSGIVR-GKRGVIGNGVALDPEALLAEIA 83
Cdd:TIGR00184   1 VVVGGQWGDEGKGKIVDLLADKPDIVARYQGGHNAGHTIVIDGVKYGLHLIPSGFLYpDAKLLIGNGVVVDPEVLLKEME 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381   84 RMAELGVSVTpDNLSIAENATLVLPIHRAIDEAQERLR-REPIGTTLRGIGPAYEDKVGRRALRVADLAEPDRLADKLDV 162
Cdd:TIGR00184  81 YLEKRGISVR-DRLFVSYRCHLILPYHKKLDKAREKSKlAKKIGTTGKGIGPAYEDKVARSGLRVGDLLDDEAFAEKAKN 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381  163 LVDHHNAWFRGL-GLAPSSRDVMLATLVELAPKILPFVRPVWAELNDAHARGERILFEGSQAVMLDIDWGTYPFVTSSGT 241
Cdd:TIGR00184 160 ILEYLNEQLVKYyKDEGVDYEKKLDEYMKYAEELKPFVVDVSVELNEALDEGEKVLFEGAQGTMLDIDYGTYPYVTSSNT 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381  242 IASAAAAGTGLGASKLGHVLGVTKAYATRVGGGPFLTELGDATGERLRTRGREFGVNTGRPRRCGWLDAAQLRQAVCVSG 321
Cdd:TIGR00184 240 TAGGVATGVGIGPTKVDEVIGVFKAYTTRVGAGPFPTELSDEEGEKLGTKGAEFGTTTGRRRRCGWFDLVAARYACRLNG 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381  322 IDSLALTKLDVLDGFESIALCVGYELDGARIAHLPTSLDAQLRVRPIYEEFAGWDGTVKGVRERAALPRAAQAFIERVEA 401
Cdd:TIGR00184 320 ATQLALTKLDVLDGIDEIKVCVAYRMKGEILELFPLDLKDLKGVEPIYETLPGWDKECTGVTEYSDLPENAKKYIERIEE 399

                         410       420
                  ....*....|....*....|....*.
gi 981233381  402 VAGAPVSMITTGAERDDTIVLSNPFD 427
Cdd:TIGR00184 400 LTGVPVTIISTGPEREQTIDLRKELL 425
AdSS cd03108
adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in ...
 2-421 3.24e-138

adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-phosphate group of GTP is transferred to the 6-oxygen atom of IMP. An aspartate then displaces this 6-phosphate group to form the product adenylosuccinate. Because of its critical role in purine biosynthesis, AdSS is a target of antibiotics, herbicides and antitumor drugs.


Pssm-ID: 349762  Cd Length: 316  Bit Score: 398.41  E-value: 3.24e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381   2 PNVVVVGAQWGDEGKGRVVDWLAAQADLVARYNGGHNAGHTLVVGGKTYKLALLPSGIVRGK-RGVIGNGVALDPEALLA 80
Cdd:cd03108    1 KVTVVVGAQWGDEGKGKIVDYLAEKADIVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNaTCVIGNGVVIDPPALFE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381  81 EIARMAELGVSVtPDNLSIAENATLVLPIHRAIDEAQE-RLRREPIGTTLRGIGPAYEDKVGRRALRVADlaepdrladk 159
Cdd:cd03108   81 EIEELEKKGIDV-KGRLLISDRAHLVFPYHQELDGLEEkERGGKKIGTTKRGIGPAYADKAARTGIRVGD---------- 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 160 ldvlvdhhnawfrglglapssrdvmlatlvelapkilPFVRPVWAELNDAHARGERILFEGSQAVMLDIDWGTYPFVTSS 239
Cdd:cd03108  150 -------------------------------------PYVVDTVELLNEALKAGKKVLFEGAQGTLLDIDFGTYPYVTSS 192

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 240 GTIASAAAAGTGLGASKLGHVLGVTKAYATRVGGGPFLTELGDATGERLRTRGREFGVNTGRPRRCGWLDAAQLRQAVCV 319
Cdd:cd03108  193 NTTAGGVCTGLGIPPRRVDRVIGVVKAYTTRVGSGPFPTELFDEEGEKLRELGHEYGTTTGRPRRCGWLDLVALRYAVRI 272

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 320 SGIDSLALTKLDVldgfesialcvgyeldgariahlptsldaqlrvrpiyeefagwdgtvkgvreraalprAAQAFIERV 399
Cdd:cd03108  273 NGLTELALTKLDV----------------------------------------------------------NAQKYIERI 294

                        410       420
                 ....*....|....*....|..
gi 981233381 400 EAVAGAPVSMITTGAERDDTIV 421
Cdd:cd03108  295 EELLGVPITYISVGPDREQTII 316
amino_Aden_PurZ NF038379
succino-amino-deoxyadenylate synthase PurZ;
5-321 1.96e-23

succino-amino-deoxyadenylate synthase PurZ;


Pssm-ID: 468496  Cd Length: 292  Bit Score: 99.37  E-value: 1.96e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381   5 VVVGAQWGDEGKGRVVDWLA--AQADLVARYNGGhNAGHTLV-VGGKTYKLALLPSGIV--RGKRGVIGNGVALDPEALL 79
Cdd:NF038379   3 VVVDGQFGSTGKGLIAGYLAerAAPDVVVRAAGP-NAGHTYIdDEGRKFVHRMLPNGIVspPLKQVLIGPGSEIDLEVLR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381  80 AEIARMAELGVSVTpDNLSIAENATlVLPIHRAIDEAQERLRRepIGTTLRGIGPAYEDKVGRRALRVadlaePDRLADK 159
Cdd:NF038379  82 EEIEELEDAGHDVG-KRLLIHEQAT-VIELHKHVEEEAGPMTK--IGSTKKGIGAARAAKIRRNPSTL-----GDAEGDF 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 160 LDVLVDHHNAWFRglglapssrdvmlatlvelapkilpfVRPVWAELND-AHARGERILFEGSQAVMLDIDWGTYPFVTS 238
Cdd:NF038379 153 GEGAVRDQPWEIA--------------------------ERVVDNALYDfALQAAERIQIEGTQGYSLGLHAGFYPYCTS 206

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 239 S--GTIASAAAAGTGLGASKLGHVLGVTKAYATRVGG--GPFLTELGDATGERLRTRgREFGVNTGRPRRCGWLDAAQLR 314
Cdd:NF038379 207 RdcTPADFLADAGIPLPNVDAFKVVGTARTYPIRVAGwsGNSYPDQGETTWEELGLP-EELTTVTKKVRRVGTFSAEQVR 285


                 ....*..
gi 981233381 315 QAVCVSG 321
Cdd:NF038379 286 EAVQANG 292
 
Name Accession Description Interval E-value
PRK01117 PRK01117
adenylosuccinate synthetase; Provisional
 1-427 0e+00

adenylosuccinate synthetase; Provisional


Pssm-ID: 234904  Cd Length: 430  Bit Score: 657.50  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381   1 MPNVVVVGAQWGDEGKGRVVDWLAAQADLVARYNGGHNAGHTLVVGGKTYKLALLPSGIVR-GKRGVIGNGVALDPEALL 79
Cdd:PRK01117   1 MKNVVVVGTQWGDEGKGKIVDLLSERADVVVRFQGGHNAGHTLVIDGKKYKLHLIPSGILRpGKTCVIGNGVVLDPEALL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381  80 AEIARMAELGVSVtPDNLSIAENATLVLPIHRAIDEAQERLRRE-PIGTTLRGIGPAYEDKVGRRALRVADLAEPDRLAD 158
Cdd:PRK01117  81 KEIDELEARGVDV-RERLRISERAHLILPYHRALDKAREKARGKkKIGTTGRGIGPAYEDKVARRGIRVGDLLDPETFAE 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 159 KLDVLVDHHNAWFRGL-GLAPSSRDVMLATLVELAPKILPFVRPVWAELNDAHARGERILFEGSQAVMLDIDWGTYPFVT 237
Cdd:PRK01117 160 KLEENLEYKNFLLTKYyGAEAVDFEEILDEYLEYAERLKPYVTDTSLLLNDALKAGKRVLFEGAQGTLLDIDHGTYPFVT 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 238 -----------------SsgtiasaaaagtglgasKLGHVLGVTKAYATRVGGGPFLTELGDATGERLRTRGREFGVNTG 300
Cdd:PRK01117 240 ssnttaggaatgsgvgpT-----------------KIDYVLGIAKAYTTRVGSGPFPTELFDEVGEHLRERGHEFGTTTG 302

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 301 RPRRCGWLDAAQLRQAVCVSGIDSLALTKLDVLDGFESIALCVGYELDGARIAHLPTSLDAQLRVRPIYEEFAGWDGTVK 380
Cdd:PRK01117 303 RPRRCGWFDAVALRYAVRVNGLTGLALTKLDVLDGLEEIKICVAYELDGKRIDYFPASLEDLARCEPIYEELPGWSESTT 382

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 981233381 381 GVRERAALPRAAQAFIERVEAVAGAPVSMITTGAERDDTIVLSNPFD 427
Cdd:PRK01117 383 GVRSFDDLPENARKYIKRIEELTGVPISIISTGPDRDQTIILRDPFA 429
PurA COG0104
Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is ...
 3-422 0e+00

Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439874  Cd Length: 423  Bit Score: 632.82  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381   3 NVVVVGAQWGDEGKGRVVDWLAAQADLVARYNGGHNAGHTLVVGGKTYKLALLPSGIVR-GKRGVIGNGVALDPEALLAE 81
Cdd:COG0104    1 NVVVVGAQWGDEGKGKIVDLLAERADVVVRFQGGNNAGHTVVVGGKKFKLHLIPSGILRpGKTCVIGNGVVLDPEALLEE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381  82 IARMAELGVSVTpDNLSIAENATLVLPIHRAIDEAQERLR-REPIGTTLRGIGPAYEDKVGRRALRVADLAEPDRLADKL 160
Cdd:COG0104   81 IDGLEARGVDVR-SRLRISERAHLILPYHRALDKAREEARgKKKIGTTGRGIGPAYEDKVARRGIRVGDLLDPEVLREKL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 161 DVLVDHHNAWFRGL-GLAPSSRDVMLATLVELAPKILPFVRPVWAELNDAHARGERILFEGSQAVMLDIDWGTYPFVT-- 237
Cdd:COG0104  160 EELLEYKNFLLEKLyGAEPLDFEELLEEYLEYAERLKPYVADTSELLNEALKAGKKVLFEGAQGTLLDIDHGTYPYVTss 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 238 ---------------SsgtiasaaaagtglgasKLGHVLGVTKAYATRVGGGPFLTELGDATGERLRTRGREFGVNTGRP 302
Cdd:COG0104  240 nttaggactgsgvgpT-----------------KIDRVIGVVKAYTTRVGEGPFPTELFDETGERLRERGHEFGTTTGRP 302

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 303 RRCGWLDAAQLRQAVCVSGIDSLALTKLDVLDGFESIALCVGYELDGARIAHLPTSLDAQLRVRPIYEEFAGWDGTVKGV 382
Cdd:COG0104  303 RRCGWLDAVALRYAVRINGLTGLALTKLDVLDGLDEIKVCVAYELDGERIDEFPASLEDLARCEPVYEELPGWKEDISGI 382

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 981233381 383 RERAALPRAAQAFIERVEAVAGAPVSMITTGAERDDTIVL 422
Cdd:COG0104  383 RSFEDLPENARAYVERIEELLGVPISIVSVGPDREQTIVR 422
Adenylsucc_synt pfam00709
Adenylosuccinate synthetase;
5-420 0e+00

Adenylosuccinate synthetase;


Pssm-ID: 459912  Cd Length: 417  Bit Score: 618.60  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381    5 VVVGAQWGDEGKGRVVDWLAAQADLVARYNGGHNAGHTLVVGGKTYKLALLPSGIVR-GKRGVIGNGVALDPEALLAEIA 83
Cdd:pfam00709   1 VVVGAQWGDEGKGKIVDLLAEDADVVVRFQGGNNAGHTVVVDGKKYKLHLLPSGILNpGKTNVIGNGVVIDPPALLEEIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381   84 RMAELGVSVtPDNLSIAENATLVLPIHRAIDEAQERLRRE-PIGTTLRGIGPAYEDKVGRRALRVADLAEPDRLADKLDV 162
Cdd:pfam00709  81 ELEERGIDV-PDRLFISDRAHLILPYHKALDGLREEARGKkKIGTTGRGIGPAYSDKAARRGIRVGDLLDPEVFREKLEA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381  163 LVDHHNAWFRGLGLAPSSRDVMLATLVELAPKILPFVRPVWAELNDAHARGERILFEGSQAVMLDIDWGTYPFVTSSGTI 242
Cdd:pfam00709 160 LLELKNKLLEKLYGEPLDVEEELEELLEYAERLKPYVVDTSYFLNKALKEGKKILFEGAQGTLLDIDHGTYPYVTSSNTT 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381  243 ASAAAAGTGLGASKLGHVLGVTKAYATRVGGGPFLTELGDATGERLRTRGREFGVNTGRPRRCGWLDAAQLRQAVCVSGI 322
Cdd:pfam00709 240 AGGACTGLGIGPTKIDEVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGATTGRPRRCGWLDLVALRYAVRINGV 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381  323 DSLALTKLDVLDGFESIALCVGYELDGARIAHLPTSLDAQLRVRPIYEEFAGWDGTVKGVRERAALPRAAQAFIERVEAV 402
Cdd:pfam00709 320 TGLALTKLDVLDGLDEIKVCVAYELDGKRIDYFPADLEDLEKVEPVYETLPGWKEDISGVRSFEDLPENARKYVEFIEEL 399

                         410
                  ....*....|....*...
gi 981233381  403 AGAPVSMITTGAERDDTI 420
Cdd:pfam00709 400 LGVPIKIISVGPDREQTI 417
Adenylsucc_synt smart00788
Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine ...
 3-421 0e+00

Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine biosynthesis, by catalyzing the GTP-dependent conversion of IMP and aspartic acid to AMP. Adenylosuccinate synthetase has been characterized from various sources ranging from Escherichia coli (gene purA) to vertebrate tissues. In vertebrates, two isozymes are present - one involved in purine biosynthesis and the other in the purine nucleotide cycle. The crystal structure of adenylosuccinate synthetase from E. coli reveals that the dominant structural element of each monomer of the homodimer is a central beta-sheet of 10 strands. The first nine strands of the sheet are mutually parallel with right-handed crossover connections between the strands. The 10th strand is antiparallel with respect to the first nine strands. In addition, the enzyme has two antiparallel beta-sheets, comprised of two strands and three strands each, 11 alpha-helices and two short 3/10-helices. Further, it has been suggested that the similarities in the GTP-binding domains of the synthetase and the p21ras protein are an example of convergent evolution of two distinct families of GTP-binding proteins. Structures of adenylosuccinate synthetase from Triticum aestivum and Arabidopsis thaliana when compared with the known structures from E. coli reveals that the overall fold is very similar to that of the E. coli protein.


Pssm-ID: 197875  Cd Length: 417  Bit Score: 612.56  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381     3 NVVVVGAQWGDEGKGRVVDWLAAQADLVARYNGGHNAGHTLVVGGKTYKLALLPSGIVR-GKRGVIGNGVALDPEALLAE 81
Cdd:smart00788   1 VVVVVGAQWGDEGKGKIVDYLAEKADVVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNpNKKNVIGNGVVIDPEALFKE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381    82 IARMAELGVSVTpDNLSIAENATLVLPIHRAIDEAQERLRrepIGTTLRGIGPAYEDKVGRRALRVADLAEPDRLADKLD 161
Cdd:smart00788  81 IEELEAKGVDVK-DRLFISDRAHLILPYHIALDKAREKAR---IGTTGRGIGPAYEDKVARRGIRVGDLFDEEVLREKLE 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381   162 VLVDHHNAWFRGL-GLAPSSRDVMLATLVELAPKILPFVRPVWAELNDAHARGERILFEGSQAVMLDIDWGTYPFVTSSG 240
Cdd:smart00788 157 ELLDYKNFLLKKLyGAEPVDVEEILEELLEYAERLRPYVTDVSELLNEALKAGKKVLFEGAQGTLLDIDHGTYPYVTSSN 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381   241 TIASAAAAGTGLGASKLGHVLGVTKAYATRVGGGPFLTELGDATGERLRTRGREFGVNTGRPRRCGWLDAAQLRQAVCVS 320
Cdd:smart00788 237 TTAGGAATGAGIGPTRIDRVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGTTTGRPRRCGWFDAVLLRYAVRIN 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381   321 GIDSLALTKLDVLDGFESIALCVGYELDGARIAHLPTSLDAQLRVRPIYEEFAGWDGTVKGVRERAALPRAAQAFIERVE 400
Cdd:smart00788 317 GITGLALTKLDVLDGLDEIKVCVAYKLDGKIIDYFPADLEDLERCEPIYEELPGWKEDTTGVRSYEDLPENAKKYIERIE 396

                          410       420
                   ....*....|....*....|.
gi 981233381   401 AVAGAPVSMITTGAERDDTIV 421
Cdd:smart00788 397 ELVGVPVSIISTGPDREQTIV 417
purA TIGR00184
adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, ...
 5-427 1.03e-154

adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272949  Cd Length: 425  Bit Score: 444.30  E-value: 1.03e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381    5 VVVGAQWGDEGKGRVVDWLAAQADLVARYNGGHNAGHTLVVGGKTYKLALLPSGIVR-GKRGVIGNGVALDPEALLAEIA 83
Cdd:TIGR00184   1 VVVGGQWGDEGKGKIVDLLADKPDIVARYQGGHNAGHTIVIDGVKYGLHLIPSGFLYpDAKLLIGNGVVVDPEVLLKEME 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381   84 RMAELGVSVTpDNLSIAENATLVLPIHRAIDEAQERLR-REPIGTTLRGIGPAYEDKVGRRALRVADLAEPDRLADKLDV 162
Cdd:TIGR00184  81 YLEKRGISVR-DRLFVSYRCHLILPYHKKLDKAREKSKlAKKIGTTGKGIGPAYEDKVARSGLRVGDLLDDEAFAEKAKN 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381  163 LVDHHNAWFRGL-GLAPSSRDVMLATLVELAPKILPFVRPVWAELNDAHARGERILFEGSQAVMLDIDWGTYPFVTSSGT 241
Cdd:TIGR00184 160 ILEYLNEQLVKYyKDEGVDYEKKLDEYMKYAEELKPFVVDVSVELNEALDEGEKVLFEGAQGTMLDIDYGTYPYVTSSNT 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381  242 IASAAAAGTGLGASKLGHVLGVTKAYATRVGGGPFLTELGDATGERLRTRGREFGVNTGRPRRCGWLDAAQLRQAVCVSG 321
Cdd:TIGR00184 240 TAGGVATGVGIGPTKVDEVIGVFKAYTTRVGAGPFPTELSDEEGEKLGTKGAEFGTTTGRRRRCGWFDLVAARYACRLNG 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381  322 IDSLALTKLDVLDGFESIALCVGYELDGARIAHLPTSLDAQLRVRPIYEEFAGWDGTVKGVRERAALPRAAQAFIERVEA 401
Cdd:TIGR00184 320 ATQLALTKLDVLDGIDEIKVCVAYRMKGEILELFPLDLKDLKGVEPIYETLPGWDKECTGVTEYSDLPENAKKYIERIEE 399

                         410       420
                  ....*....|....*....|....*.
gi 981233381  402 VAGAPVSMITTGAERDDTIVLSNPFD 427
Cdd:TIGR00184 400 LTGVPVTIISTGPEREQTIDLRKELL 425
PLN02513 PLN02513
adenylosuccinate synthase
 3-422 1.05e-149

adenylosuccinate synthase


Pssm-ID: 178129  Cd Length: 427  Bit Score: 431.76  E-value: 1.05e-149
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381   3 NVVVVGAQWGDEGKGRVVDWLAAQADLVARYNGGHNAGHTLVVG-GKTYKLALLPSGIVR-GKRGVIGNGVALDPEALLA 80
Cdd:PLN02513   4 VSAVLGTQWGDEGKGKLVDILAQHFDIVARCQGGANAGHTIYNDeGKKFALHLVPSGILNeKTTCVIGNGVVVHLPGLFE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381  81 EIARMAELGVSVTpDNLSIAENATLVLPIHRAIDEAQE-RLRREPIGTTLRGIGPAYEDKVGRRALRVADLAEPDRLADK 159
Cdd:PLN02513  84 EIDGLESNGVSCE-GRLLVSDRAHLLFDFHQEVDGLREaELAGSKIGTTKRGIGPAYSSKATRNGLRVGDLRHMDTFAEK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 160 LDVLVDHHNAWFRGLGLAPSSRDVMLATLVELAPKILPFVRPVWAELNDAHARGERILFEGSQAVMLDIDWGTYPFVTSS 239
Cdd:PLN02513 163 LRELLADAAARFEGFEYDASMVEEEVEAYKKFAERLEPFITDTVHYLNEAIQAGKKILVEGAQATMLDIDFGTYPFVTSS 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 240 GTIASAAAAGTGLGASKLGHVLGVTKAYATRVGGGPFLTELGDATGERLRTRGREFGVNTGRPRRCGWLDAAQLRQAVCV 319
Cdd:PLN02513 243 NPSAGGICTGLGIAPRKLGDIIGVVKAYTTRVGSGPFPTELFGELGDLLREAGQEFGTTTGRPRRCGWLDIVALKYSCQI 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 320 SGIDSLALTKLDVLDGFESIALCVGYEL-DGARIAHLPTSLDAQLRVRPIYEEFAGWDGTVKGVRERAALPRAAQAFIER 398
Cdd:PLN02513 323 NGFTSLNLTKLDVLSGLPEIKIGVAYKTpDGKVVKSFPADLDTLEQVEVVYEVLPGWQEDISSVRNYDDLPAAAQAYVER 402

                        410       420
                 ....*....|....*....|....
gi 981233381 399 VEAVAGAPVSMITTGAERDDTIVL 422
Cdd:PLN02513 403 IEELVGVPVHYIGVGPGRDALIVK 426
PTZ00350 PTZ00350
adenylosuccinate synthetase; Provisional
 4-421 2.76e-141

adenylosuccinate synthetase; Provisional


Pssm-ID: 240376  Cd Length: 436  Bit Score: 410.57  E-value: 2.76e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381   4 VVVVGAQWGDEGKGRVVDWLAAQADLVARYNGGHNAGHTLVVGGKTYKLALLPSGIVRGK-RGVIGNGVALDPEALLAEI 82
Cdd:PTZ00350  15 VVILGAQWGDEGKGKLVDILSEKADIVARFNGGANAGHTIVVDGKKYALHLLPCGILYPNcINVLGNGVVIHLPSLLEEI 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381  83 ARMAELGVSVTpDNLSIAENATLVLPIHRAIDEAQERLRRE---PIGTTLRGIGPAYEDKVGRRALRVADLAEPDRLADK 159
Cdd:PTZ00350  95 EQLTKKGINLL-GRLYISDRAHLVFDLHQAIDGIQESEKGKggtQIGTTKRGIGPCYSTKASRTGLRVGDLLNFETFEKK 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 160 LDVLVDHHNAWFRGLGLAPSSRdvmLATLVELAPKILPFVRPVWAELNDAHARGERILFEGSQAVMLDIDWGTYPFVTSS 239
Cdd:PTZ00350 174 YRKLVEKLQEQYNIEEYDAEEE---LERYKGYAEKLKDMIVDTVYFMNKAIKEGKRVLVEGANATMLDIDFGTYPYVTSS 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 240 GTIASAAAAGTGLGASKLGHVLGVTKAYATRVGGGPFLTELGDATGERLRTRGREFGVNTGRPRRCGWLDAAQLRQAVCV 319
Cdd:PTZ00350 251 NTTVGGVCTGLGIPPNAIILVIGVVKAYTTRVGEGPFPTELFDENGDYLRKKGHEYGTTTGRPRRCGWLDIPALRYVQMI 330

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 320 SGIDSLALTKLDVLDGFESIALCVGYEL--DGARIAHLPTSLDAQLRVRPIYEEFAGWDGTVKGVRERAALPRAAQAFIE 397
Cdd:PTZ00350 331 NGFDSINLTKLDVLSGLKEIKICVNYKNkgTGLEIGRYPSSIEELEEYEPVYETMPGWKTDISKCKTFEELPENAQKYVL 410

                        410       420
                 ....*....|....*....|....
gi 981233381 398 RVEAVAGAPVSMITTGAERDDTIV 421
Cdd:PTZ00350 411 FIEELLGVPIVWIGVGPNRENMIV 434
AdSS cd03108
adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in ...
 2-421 3.24e-138

adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-phosphate group of GTP is transferred to the 6-oxygen atom of IMP. An aspartate then displaces this 6-phosphate group to form the product adenylosuccinate. Because of its critical role in purine biosynthesis, AdSS is a target of antibiotics, herbicides and antitumor drugs.


Pssm-ID: 349762  Cd Length: 316  Bit Score: 398.41  E-value: 3.24e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381   2 PNVVVVGAQWGDEGKGRVVDWLAAQADLVARYNGGHNAGHTLVVGGKTYKLALLPSGIVRGK-RGVIGNGVALDPEALLA 80
Cdd:cd03108    1 KVTVVVGAQWGDEGKGKIVDYLAEKADIVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNaTCVIGNGVVIDPPALFE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381  81 EIARMAELGVSVtPDNLSIAENATLVLPIHRAIDEAQE-RLRREPIGTTLRGIGPAYEDKVGRRALRVADlaepdrladk 159
Cdd:cd03108   81 EIEELEKKGIDV-KGRLLISDRAHLVFPYHQELDGLEEkERGGKKIGTTKRGIGPAYADKAARTGIRVGD---------- 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 160 ldvlvdhhnawfrglglapssrdvmlatlvelapkilPFVRPVWAELNDAHARGERILFEGSQAVMLDIDWGTYPFVTSS 239
Cdd:cd03108  150 -------------------------------------PYVVDTVELLNEALKAGKKVLFEGAQGTLLDIDFGTYPYVTSS 192

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 240 GTIASAAAAGTGLGASKLGHVLGVTKAYATRVGGGPFLTELGDATGERLRTRGREFGVNTGRPRRCGWLDAAQLRQAVCV 319
Cdd:cd03108  193 NTTAGGVCTGLGIPPRRVDRVIGVVKAYTTRVGSGPFPTELFDEEGEKLRELGHEYGTTTGRPRRCGWLDLVALRYAVRI 272

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 320 SGIDSLALTKLDVldgfesialcvgyeldgariahlptsldaqlrvrpiyeefagwdgtvkgvreraalprAAQAFIERV 399
Cdd:cd03108  273 NGLTELALTKLDV----------------------------------------------------------NAQKYIERI 294

                        410       420
                 ....*....|....*....|..
gi 981233381 400 EAVAGAPVSMITTGAERDDTIV 421
Cdd:cd03108  295 EELLGVPITYISVGPDREQTII 316
PRK13786 PRK13786
adenylosuccinate synthetase; Provisional
 5-420 2.96e-124

adenylosuccinate synthetase; Provisional


Pssm-ID: 184325  Cd Length: 424  Bit Score: 366.82  E-value: 2.96e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381   5 VVVGAQWGDEGKGRVVDWLAAQADLVARYNGGHNAGHTLVVGGKTYKLALLPSGIVRGKRGVIGNGVALDPEALLAEIAR 84
Cdd:PRK13786   4 IITGAQFGDEGKGKIVDLLAKDYDIVARFQGGDNAGHTVKVGDEVYKLHLIPSGFLLDARVLIGPGVVLNPEVLAEEIDM 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381  85 MAELGVSVTPDNLSIAENATLVLPIHRAIDEAQERLRREPIGTTLRGIGPAYEDKVGRRALRVADLAEPDRLADKLDVLV 164
Cdd:PRK13786  84 LEKHGVKVDAEKLGIDAKTSIIMPYHIELDGLRESARTEKIGTTKRGIGFAYIDKIARDEVRMSDLVDKERLMRRLEELA 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 165 DHHNAWFRGLGLAPS-SRD-VMLATLVELAPKILPFVRPVWAELNDAHARGERILFEGSQAVMLDIDWGTYPFVTSSGTI 242
Cdd:PRK13786 164 PQKEKEIKELGGDPSiVRDeALIDKYLELGRQLAPYITDVSYEINKALDEGKSVLAEGAQGTHLDVIHGTQKFVTSSSTI 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 243 ASAAAAGTGLGASKLGHVLGVTKAYATRVGGGPFLTELGDATGERLRTRGREFGVNTGRPRRCGWLDAAQLRQAVCVSGI 322
Cdd:PRK13786 244 AGSACANLGVGPTRVDNVLGIVKAYITRVGEGPLPTELKDEAGEHLQDVGGEFGTTTGRPRRCGWFDLPLLKKAIYLNGY 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 323 DSLALTKLDVLDGFESIALCVGYELDGARIAHLPTSLDAQLRVRPIYEEFAGWDGTVKGVRERAALPRAAQAFIERVEAV 402
Cdd:PRK13786 324 TEIALTKLDVLTGLDPIKICVGYELDGEILDYPPELTSDLARCVPVYEELEGWSTDLTEVKAYEDLPENARNYVERLEEL 403

                        410
                 ....*....|....*...
gi 981233381 403 AGAPVSMITTGAERDDTI 420
Cdd:PRK13786 404 MGVPIKYISVGPGREQTF 421
PRK13787 PRK13787
adenylosuccinate synthetase; Provisional
 1-422 3.53e-121

adenylosuccinate synthetase; Provisional


Pssm-ID: 172324  Cd Length: 423  Bit Score: 358.88  E-value: 3.53e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381   1 MPNVVVVGAQWGDEGKGRVVDWLAAQADLVARYNGGHNAGHTLVVGGKTYKLALLPSGIVRGKRG-VIGNGVALDPEALL 79
Cdd:PRK13787   1 MPASLVVGTQWGDEGKAKVIDFLSKDTDIIVRYQGGANAGHTVVVHGKKYVFHLVPSGVIYDQTIcVIGNGVVLDPLFFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381  80 AEIARMAELGVSVTpDNLSIAENATLVLPIHRAIDEAQERL--RREPIGTTLRGIGPAYEDKVGRRALRVADLAEpDRLA 157
Cdd:PRK13787  81 EECDRLQKEGFPVK-DKLLLSDACHLLFPYHSQIDSARETTssQEHKIGTTKKGIGICYADKMMRTGLRVGDLLD-KSYK 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 158 DKLDVLVDHHNAWFRGL-GLAPSSRDVMLATLVELAPKILPFVRPVWAELNDAHARGERILFEGSQAVMLDIDWGTYPFV 236
Cdd:PRK13787 159 RRLKHLVDEKNRELDKLyGMPPVSYNDINDGLKFFLSKVGKNIINTAYYLDTELKKGKRVLLEGAQGTGLDVDFGTYPYV 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 237 TSSGTIASAAAAGTGLGASKLGHVLGVTKAYATRVGGGPFLTELGDATGERLRTRGREFGVNTGRPRRCGWLDAAQLRQA 316
Cdd:PRK13787 239 TSSNPTTGGALIGTGISFQHLKHVIGITKAYTTRVGEGPFPTELLGEAGEVLRQKGGEFGATTGRPRRCGWFDVEMLKHS 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 317 VCVSGIDSLALTKLDVLDGFESIALCVGYELDGARIAHLPTSldAQLRVRPIYEEFAGWDGTVKGVRERAALPRAAQAFI 396
Cdd:PRK13787 319 VRINGITSIALTKIDILSDYDTIPVAVGYKLNGKTLDCFPSQ--GLEKVEPLYEEFPGWKDDISGINEFQKLPEKCKNYI 396

                        410       420
                 ....*....|....*....|....*.
gi 981233381 397 ERVEAVAGAPVSMITTGAERDDTIVL 422
Cdd:PRK13787 397 SALEKWIGVKINLVSTGPDRKDTIIG 422
PRK13788 PRK13788
adenylosuccinate synthetase; Provisional
 1-419 3.08e-120

adenylosuccinate synthetase; Provisional


Pssm-ID: 184326 [Multi-domain]  Cd Length: 404  Bit Score: 356.04  E-value: 3.08e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381   1 MPNVVVVGAQWGDEGKGRVVDWLAAQADLVARYNGGHNAGHTLVVGGKTYKLALLPSGIVR-GKRGVIGNGVALDPEALL 79
Cdd:PRK13788   1 MPGIAIIGAQWGDEGKGKVVDALAPEADFVVRYQGGANAGHTVVAKGKTFKLNLLPSGVLHpHATSVLGDGMVIDPFRFA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381  80 AEIARMAELGVsvtPDNLSIAENATLVLPIHRAIDEaqerlRREPIGTTLRGIGPAYEDKVGRRALRVADLAEPDRLADK 159
Cdd:PRK13788  81 EERENLRAGGL---NPKLLISERAHLVLPHHKYVDG-----RKNFVGTTGRGIGPAYSDRARRVGIRFGDLLDEAVLRER 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 160 LDVLVDHHNAWFRGLGLApsSRDVMLATLVELAPKILPFVRPVWAELNDAHARGERILFEGSQAVMLDIDWGTYPFVTSS 239
Cdd:PRK13788 153 VERLLEAKPNSTREAGWD--TVEKALADLAPMREILLPFIADTGSLLREAIREGKRVLFEGAQATLLDLNYGTYPYVTSS 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 240 GTIASAAAAGTGLGASKLGHVLGVTKAYATRVGGGPFLTELGDATGERLRTRG----REFGVNTGRPRRCGWLDAAQLRQ 315
Cdd:PRK13788 231 HPTVGGILVGAGVNHKAINKVYGVAKAFTTRVGHGPFPTEVFGEMAIRLRGKGgnpwDEFGTTTGRARRVGWLDLVLLKY 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 316 AVCVSGIDSLALTKLDVLDGFESIALCVGYELDGariahlptsldaqlrvRPIYEEFAGWdGTVKGVRERAALPRAAQAF 395
Cdd:PRK13788 311 ACEVNGFDGLVLTKLDVLSGLEKVKVCVEYDDDG----------------QPVYKELPGW-GDLDGVKSREALPKEAQAY 373

                        410       420
                 ....*....|....*....|....
gi 981233381 396 IERVEAVAGAPVSMITTGAERDDT 419
Cdd:PRK13788 374 LELIEETTGVPVVMFSTSPRREDT 397
PRK13783 PRK13783
adenylosuccinate synthetase; Provisional
 3-420 4.35e-118

adenylosuccinate synthetase; Provisional


Pssm-ID: 237505  Cd Length: 404  Bit Score: 350.56  E-value: 4.35e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381   3 NVVVVGAQWGDEGKGRVVDWLAAQADLVARYNGGHNAGHTLVVGGKTYKLALLPSGIVRG-KRGVIGNGVALDPEALLAE 81
Cdd:PRK13783   2 KRVIVGLQWGDEGKGKVVTYLSRYYDIVVRYSGGANAGHTVNYGDFKVVHHLLPSADFKKnVGAAIGNGVVLDLEVLVEE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381  82 IARMAELGVSVtPDNLSIAENATLVLPIHRAIDEAQERLRREPIGTTLRGIGPAYEDKVGRRALRVADLAEPDRLADKLD 161
Cdd:PRK13783  82 LEELKEKFPDY-SGRIFISELAHVVLPVHKELDEIIESVRKNAIGTTKRGIGPAYADKVMRVGVRLADLFDEEKLREFLE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 162 VLVDHHNAWFRglglAPSSRDVMLATLVELAPKILPFVRPVwAELNDAhARGERILFEGSQAVMLDIDWGTYPFVTSSGT 241
Cdd:PRK13783 161 KILSLYKKLYG----IEFDVEKMMEDLLTFYEKIKDLVVSP-VEIKRI-LEEKSVLFEGTQGVLLDLDVGTYPYVTSSNC 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 242 IASAAAAGTGLGAsKLGHVLGVTKAYATRVGGGPFLTELGDATGERLRTRGREFGVNTGRPRRCGWLDAAQLRQAVCVSG 321
Cdd:PRK13783 235 STTGVSAGMGFPV-KVDEVIGVFKAYTTRVGEGPFPTELFGEEGEKLRKAGHEYGATTGRPRRCGWLDLPLLRYAIEVSG 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 322 IDSLALTKLDVLDGFESIALCVGYELDGaRIAHLPTSLDAQLRVRPIYEEFAGWdgtvKGVRERAALpraaqAFIERVEA 401
Cdd:PRK13783 314 VDSLVMTKADVLNGFEKIKVCVRYEIGG-KEVRDPSSLRDLEKAEPVYEEFDGW----KSLEDKNFL-----KFVDFIER 383

                        410
                 ....*....|....*....
gi 981233381 402 VAGAPVSMITTGAERDDTI 420
Cdd:PRK13783 384 ETGRKIAYISTGPKIEEIV 402
PRK13785 PRK13785
adenylosuccinate synthetase; Provisional
 4-426 6.97e-105

adenylosuccinate synthetase; Provisional


Pssm-ID: 237506  Cd Length: 454  Bit Score: 318.24  E-value: 6.97e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381   4 VVVVGAQWGDEGKGRVVDWLAAQADLVARYNGGHNAGHTLVVGGKTYKLALLPSGIVRGKRGVIGNGVALDPEALLAEIA 83
Cdd:PRK13785   3 VTIVGSQLGDEGKGGVVDLYGDAADVVVRYQGGDNAGHTVVHGGEEYKLSLVPSGAVRGKIGVLGNGCVVNPETLFDEID 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381  84 RMAELGVsvTPDnLSIAENATLVLPIHRAIDEAQERLRREP---IGTTLRGIGPAYEDKVGRRALRVADLAEPDRLADKL 160
Cdd:PRK13785  83 ALRERGL--DPD-VRVAERAHVILPYHRVLDGIEEEAKSDSdleVGTTGRGIGPTYEDKAGRRGVRVGDLLDPDVLRDRL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 161 DVLVDHHNAWFRG-----LGLAPSSRDV--MLATLVELAPKILPFVRPVWAE--LNDAHARGERILFEGSQAVMLDIDWG 231
Cdd:PRK13785 160 EYVVPQKRALAEDvygldASETPEAFDVdaLFEEYREYGERLAEEDMTVNAGdfLAERIDDGDNVMLEGAQGTSIDIDHG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 232 TYPFVTSSGTIASAAAAGTGLGASKL--GHVLGVTKAYATRVGGGPFLTELGDATG---------------ERLRTRGRE 294
Cdd:PRK13785 240 NYPYVTSSNPTAGGAATGTGLGPTVVgqGEVVGIVKAYLSRVGSGPLPTELGGVEGdtpdeggrpdeeelaTYIREEGGE 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 295 FGVNTGRPRRCGWLDAAQLRQAVCVSGIDSLALTKLDVLDGFESIALCVGYELDGARIAHLPTSLDAQLRVRPIYEEFAG 374
Cdd:PRK13785 320 YGTVTGRPRRVGWLDMPMLRHAARASGFTGLAINHIDVLAGLDEVKVGHSYELDGEELLTMPATTERWARCEPNFRSFDG 399

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 981233381 375 W---DGTVKGVRERAALPRAAQAFIERVEAVAGAPVSMITTGAERDDTIVLSNPF 426
Cdd:PRK13785 400 WpevDWAAVAEEGYDALPENARTYLEYVSDELDTPIYAVGVGPGREETVVLENPF 454
PRK13784 PRK13784
adenylosuccinate synthetase; Provisional
 1-426 1.11e-101

adenylosuccinate synthetase; Provisional


Pssm-ID: 172322  Cd Length: 428  Bit Score: 309.26  E-value: 1.11e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381   1 MPNVVVVGAQWGDEGKGRVVDWLAAQADLVARYNGGHNAGHTLVVGGKTYKLALLPSGIVRG-KRGVIGNGVALDPEALL 79
Cdd:PRK13784   1 MSNIVIVGAQWGDEGKGKIADTLAEKADLVVRYQGGNNAGHTLVVNGKKTFLHLIPSGVLHQhTKCVIGHGVVLDPVALD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381  80 AEIARMAELGVSVTPDNLSIAENATLVLPIHRAIDEAQERLRREPIGTTLRGIGPAYEDKVGRRALRVADLAEPDRLADK 159
Cdd:PRK13784  81 EEITRLQAKGIAISAENLFVSESCTIITSYHKLLDAVRESNTSEKIGTTGKGIGPAYEDKVSRKGIKFKHLFDKDLLRSR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 160 LDVLVDHHNAWFRGL-GLAPSSRDVMLATLVELAPKILPFVRPVWAELNDAHARGERILFEGSQAVMLDIDWGTYPFVTS 238
Cdd:PRK13784 161 LAISLAEKETLFRDLyKVEYPTLEQEFDKLFALGQKLKQYAADTFSIIDQAIAAGKNVVYEGAQGVLLDVDYGTYPFVTS 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 239 SGTIASAAAAGTGLGASKLGHVLGVTKAYATRVGGGPFLTELGDATGERLRTRGREFGVNTGRPRRCGWLDAAQLRQAVC 318
Cdd:PRK13784 241 SNTSVAGVYSGATTAGHGLDHVIGITKAYTTRVGEGPFPTELFDDVGKFIQHKGGEIGVTTGRIRRCGWLDLPLLKYSAK 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 319 VSGIDSLALTKLDVLDGFESIALCVGYELDGARIAHLPTSLDAqLRVRPIYEEFAGWdgTVKGVRERAALPRAAQAFIER 398
Cdd:PRK13784 321 CSNLTSIALTKVDVLSDMDTLKVCIGYKYEGKEIYCAYPGIDL-YKVEPILVEMEPF--SIDETVTKDNMPAALKTYLKT 397

                        410       420
                 ....*....|....*....|....*...
gi 981233381 399 VEAVAGAPVSMITTGAERDDTIVLSNPF 426
Cdd:PRK13784 398 IENHVGIPISSLAYGPSREQILFFEDYF 425
PRK04293 PRK04293
adenylosuccinate synthetase; Provisional
 1-420 8.59e-67

adenylosuccinate synthetase; Provisional


Pssm-ID: 179812  Cd Length: 333  Bit Score: 216.29  E-value: 8.59e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381   1 MPNVVVVGAQWGDEGKGRVVDWLAAQ--ADLVARYNGGHNAGHTLVVGGKTYKLALLPSGIVRGK-RGVIGNGVALDPEA 77
Cdd:PRK04293   1 MTCTIVVGGFFGDEGKGKIIAYLALKdkPSIIARGGVGPNAGHTVEYNGKKYGLRMIPSGFVNKDaKLAIGAGVLVDPEV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381  78 LLAEIArmaELGVSvtpDNLSIAENATLVLPIHRAIDEAQERLRREpIGTTLRGIGPAYEDkvgrRALRVADLAepdrla 157
Cdd:PRK04293  81 LLKEVE---ELNVG---GRVFVDYRCGIIEEKHVEEDRSDEHLSKK-IGSTGTGCGPANAD----RVLRRLKLA------ 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 158 dkldvlvdhhnawfrglglapssRDVmlatlvelaPKILPFVRPVWAELNDAHARGERILFEGSQAVMLDIDWGTYPFVT 237
Cdd:PRK04293 144 -----------------------KDV---------EELEKYLTDVPEEVNEALDRGENVLIEGTQGFGLSLYYGTYPYVT 191

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 238 SSGTIASAAAAGTGLGASKLGHVLGVTKAYATRVGGGPFLTELGDATGERlrtRG-REFGVNTGRPRRCGWLDAAQLRQA 316
Cdd:PRK04293 192 SKDTTASGIASDVGVGPTKVDEVIVVFKSYPTRVGEGPFPTELSLEEAEK---LGlVEYGTVTGRRRRVGPFDFELARRA 268

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 317 VCVSGIDSLALTKLDVLDGfesialcvgyeldgariahlptslDAqlrvrpiyeefagwdgtvKGVRERAALPRAAQAFI 396
Cdd:PRK04293 269 ARINGATQIAITKLDKLDK------------------------EA------------------YGVTEYDKLPPEAKKFI 306

                        410       420
                 ....*....|....*....|....
gi 981233381 397 ERVEAVAGAPVSMITTGAERDDTI 420
Cdd:PRK04293 307 EEIEEELGVPVTLISTGPELEDTI 330
amino_Aden_PurZ NF038379
succino-amino-deoxyadenylate synthase PurZ;
5-321 1.96e-23

succino-amino-deoxyadenylate synthase PurZ;


Pssm-ID: 468496  Cd Length: 292  Bit Score: 99.37  E-value: 1.96e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381   5 VVVGAQWGDEGKGRVVDWLA--AQADLVARYNGGhNAGHTLV-VGGKTYKLALLPSGIV--RGKRGVIGNGVALDPEALL 79
Cdd:NF038379   3 VVVDGQFGSTGKGLIAGYLAerAAPDVVVRAAGP-NAGHTYIdDEGRKFVHRMLPNGIVspPLKQVLIGPGSEIDLEVLR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381  80 AEIARMAELGVSVTpDNLSIAENATlVLPIHRAIDEAQERLRRepIGTTLRGIGPAYEDKVGRRALRVadlaePDRLADK 159
Cdd:NF038379  82 EEIEELEDAGHDVG-KRLLIHEQAT-VIELHKHVEEEAGPMTK--IGSTKKGIGAARAAKIRRNPSTL-----GDAEGDF 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 160 LDVLVDHHNAWFRglglapssrdvmlatlvelapkilpfVRPVWAELND-AHARGERILFEGSQAVMLDIDWGTYPFVTS 238
Cdd:NF038379 153 GEGAVRDQPWEIA--------------------------ERVVDNALYDfALQAAERIQIEGTQGYSLGLHAGFYPYCTS 206

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381 239 S--GTIASAAAAGTGLGASKLGHVLGVTKAYATRVGG--GPFLTELGDATGERLRTRgREFGVNTGRPRRCGWLDAAQLR 314
Cdd:NF038379 207 RdcTPADFLADAGIPLPNVDAFKVVGTARTYPIRVAGwsGNSYPDQGETTWEELGLP-EELTTVTKKVRRVGTFSAEQVR 285


                 ....*..
gi 981233381 315 QAVCVSG 321
Cdd:NF038379 286 EAVQANG 292
PTZ00351 PTZ00351
adenylosuccinate synthetase; Provisional
 4-154 1.95e-15

adenylosuccinate synthetase; Provisional


Pssm-ID: 173544  Cd Length: 710  Bit Score: 78.55  E-value: 1.95e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981233381   4 VVVVGAQWGDEGKGRVVDWLAAQ--ADLVARYNGGHNAGHTLV-VGGKTYKLALLPSG-IVRGKRGVIGNGVALDPEALL 79
Cdd:PTZ00351 172 IMVAGAFFGDEGKGKTVDAVAHHplCTCIARVNSGENAGHTVYdKAGRKFVFNLAPSGlLLPGKRNYIGPECVMDPVSFM 251

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 981233381  80 -AEIARMAELGVSVTpDNLSIAeNATLVLPIHRAIDeaqeRLRREPIGTTLRGIGPAYEDKVGRRALRVADLAEPD 154
Cdd:PTZ00351 252 eKEIIQLIDAGIDYR-DRLFIG-NVCIVTPYHKLLD----LLGSAANSSTLKGMAPVHGSKVMKRGIRLDHIFNDD 321
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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