NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|754188141|ref|WP_041804476|]
View 

MULTISPECIES: low molecular weight protein-tyrosine-phosphatase [Microcystis]

Protein Classification

low molecular weight protein-tyrosine-phosphatase( domain architecture ID 11611401)

low molecular weight protein-tyrosine-phosphatase is a small soluble single-domain enzyme that catalyzes the dephosphorylation of O-phosphotyrosine groups in phosphoproteins

EC:  3.1.3.48
Gene Ontology:  GO:0004725|GO:0006470
PubMed:  12678841|12882518|27676368
SCOP:  4000436

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LMWPTP cd16343
Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine ...
 18-166 5.49e-69

Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.


:

Pssm-ID: 319971  Cd Length: 147  Bit Score: 205.75  E-value: 5.49e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754188141  18 YKLLFVCLGNICRSPAAENIMTYLIEQEGlGNKILCDSAGTAGYHIGSPPDSRMNTAAKKRGIPLQG-TARQFTREDFEN 96
Cdd:cd16343    1 KKILFVCLGNICRSPMAEAVLRHLLPKAG-GDDVEVDSAGTSAWHGGEPPDPRARAVLKEHGIDLSGhRARQLTAEDFDE 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754188141  97 FDLILAMDKANYQDILSLDRTGkYQEKVKLMCDYARyHPEKEVPDPYYGGREGFDRVIELLLDSCGSLLE 166
Cdd:cd16343   80 FDLILAMDESNLRDLRRLAPAE-ARGKVFLLGDFDP-EGGKDVPDPYYGGREGFEEVYDLIERACEGLLE 147
 
Name Accession Description Interval E-value
LMWPTP cd16343
Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine ...
 18-166 5.49e-69

Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.


Pssm-ID: 319971  Cd Length: 147  Bit Score: 205.75  E-value: 5.49e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754188141  18 YKLLFVCLGNICRSPAAENIMTYLIEQEGlGNKILCDSAGTAGYHIGSPPDSRMNTAAKKRGIPLQG-TARQFTREDFEN 96
Cdd:cd16343    1 KKILFVCLGNICRSPMAEAVLRHLLPKAG-GDDVEVDSAGTSAWHGGEPPDPRARAVLKEHGIDLSGhRARQLTAEDFDE 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754188141  97 FDLILAMDKANYQDILSLDRTGkYQEKVKLMCDYARyHPEKEVPDPYYGGREGFDRVIELLLDSCGSLLE 166
Cdd:cd16343   80 FDLILAMDESNLRDLRRLAPAE-ARGKVFLLGDFDP-EGGKDVPDPYYGGREGFEEVYDLIERACEGLLE 147
LMWPc pfam01451
Low molecular weight phosphotyrosine protein phosphatase;
20-165 4.92e-50

Low molecular weight phosphotyrosine protein phosphatase;


Pssm-ID: 460216  Cd Length: 142  Bit Score: 157.54  E-value: 4.92e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754188141   20 LLFVCLGNICRSPAAENIMTYLIEQEGLGNKILCDSAGTAGYhIGSPPDSRMNTAAKKRGIPLQG-TARQFTREDFENFD 98
Cdd:pfam01451   1 ILFVCTGNICRSPMAEAIFRRELEKAGLGDKVEVDSAGTGAW-PGNPADPRAVEVLKEHGIDLSGhYARQLSTEDFASFD 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 754188141   99 LILAMDKANYQDILSLDrTGKYQEKVKLMCDYARyhpEKEVPDPYYGGREGFDRVIELLLDSCGSLL 165
Cdd:pfam01451  80 LILAMDSEHKRDLCPLA-PERYRAKVMLLGEYGE---QLDIPDPYYGSIDAFEEVRDLIERRCRQLL 142
Wzb COG0394
Protein-tyrosine-phosphatase [Signal transduction mechanisms];
16-169 3.12e-48

Protein-tyrosine-phosphatase [Signal transduction mechanisms];


Pssm-ID: 440163  Cd Length: 137  Bit Score: 153.01  E-value: 3.12e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754188141  16 MPYKLLFVCLGNICRSPAAENIMTYLieqegLGNKILCDSAGTAGyhiGSPPDSRMNTAAKKRGIPLQG-TARQFTREDF 94
Cdd:COG0394    2 MPKRVLFVCTGNICRSPMAEALLRHL-----AGGRVEVDSAGTEP---GGPVDPRAVAVLAERGIDLSGhRSRQLDEEDL 73

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 754188141  95 ENFDLILAMDKANYQDILSLdrtgkYQEKVKLMCDYaryhpekEVPDPYYGGREGFDRVIELLLDSCGSLLEEVK 169
Cdd:COG0394   74 PEFDLVITMCDSAAEELCPL-----FPGAAKLLLHW-------DVPDPYYGGLEAFREVRDEIERRIEALLAKLR 136
LMWPc smart00226
Low molecular weight phosphatase family;
20-166 1.10e-34

Low molecular weight phosphatase family;


Pssm-ID: 197586  Cd Length: 134  Bit Score: 118.34  E-value: 1.10e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754188141    20 LLFVCLGNICRSPAAENIMtylieQEGLGNKILCDSAGTAGYhIGSPPDSRMNTAAKKRGIPLQGTARQFTREDFENFDL 99
Cdd:smart00226   1 ILFVCTGNICRSPMAEALF-----KAYVGDRVKIDSAGTGAW-VGGGADPRAVKVLKEHGIDLSHHASQLTSSDFKNADL 74

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 754188141   100 ILAMDKANYQDILSLdrTGKYQEKVKLMCDYAryhpekEVPDPYYGGREGFDRVIELLLDSCGSLLE 166
Cdd:smart00226  75 VLAMDGSHLRNICRL--KPPSRAKVELFGHYV------DVDDPYYGGIDGFERVYDELENALQEFLK 133
etp PRK11391
phosphotyrosine-protein phosphatase; Provisional
 20-157 2.53e-18

phosphotyrosine-protein phosphatase; Provisional


Pssm-ID: 138553  Cd Length: 144  Bit Score: 76.60  E-value: 2.53e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754188141  20 LLFVCLGNICRSPAAENimtyLIEQEGLGNKIlcDSAGTAGYhIGSPPDSRMNTAAKKRGIPLQG-TARQFTREDFENFD 98
Cdd:PRK11391   5 ILVVCTGNICRSPIGER----LLRKRLPGVKV--KSAGVHGL-VKHPADATAADVAANHGVSLEGhAGRKLTAEMARNYD 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 754188141  99 LILAMDKANYQDILSLdrTGKYQEKVKLmcdYARYHPEKEVPDPYYGGREGFDRVIELL 157
Cdd:PRK11391  78 LILAMESEHIAQVTAI--APEVRGKTML---FGQWLEQKEIPDPYRKSQDAFEHVYGML 131
 
Name Accession Description Interval E-value
LMWPTP cd16343
Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine ...
 18-166 5.49e-69

Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.


Pssm-ID: 319971  Cd Length: 147  Bit Score: 205.75  E-value: 5.49e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754188141  18 YKLLFVCLGNICRSPAAENIMTYLIEQEGlGNKILCDSAGTAGYHIGSPPDSRMNTAAKKRGIPLQG-TARQFTREDFEN 96
Cdd:cd16343    1 KKILFVCLGNICRSPMAEAVLRHLLPKAG-GDDVEVDSAGTSAWHGGEPPDPRARAVLKEHGIDLSGhRARQLTAEDFDE 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754188141  97 FDLILAMDKANYQDILSLDRTGkYQEKVKLMCDYARyHPEKEVPDPYYGGREGFDRVIELLLDSCGSLLE 166
Cdd:cd16343   80 FDLILAMDESNLRDLRRLAPAE-ARGKVFLLGDFDP-EGGKDVPDPYYGGREGFEEVYDLIERACEGLLE 147
LMWPc pfam01451
Low molecular weight phosphotyrosine protein phosphatase;
20-165 4.92e-50

Low molecular weight phosphotyrosine protein phosphatase;


Pssm-ID: 460216  Cd Length: 142  Bit Score: 157.54  E-value: 4.92e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754188141   20 LLFVCLGNICRSPAAENIMTYLIEQEGLGNKILCDSAGTAGYhIGSPPDSRMNTAAKKRGIPLQG-TARQFTREDFENFD 98
Cdd:pfam01451   1 ILFVCTGNICRSPMAEAIFRRELEKAGLGDKVEVDSAGTGAW-PGNPADPRAVEVLKEHGIDLSGhYARQLSTEDFASFD 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 754188141   99 LILAMDKANYQDILSLDrTGKYQEKVKLMCDYARyhpEKEVPDPYYGGREGFDRVIELLLDSCGSLL 165
Cdd:pfam01451  80 LILAMDSEHKRDLCPLA-PERYRAKVMLLGEYGE---QLDIPDPYYGSIDAFEEVRDLIERRCRQLL 142
Wzb COG0394
Protein-tyrosine-phosphatase [Signal transduction mechanisms];
16-169 3.12e-48

Protein-tyrosine-phosphatase [Signal transduction mechanisms];


Pssm-ID: 440163  Cd Length: 137  Bit Score: 153.01  E-value: 3.12e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754188141  16 MPYKLLFVCLGNICRSPAAENIMTYLieqegLGNKILCDSAGTAGyhiGSPPDSRMNTAAKKRGIPLQG-TARQFTREDF 94
Cdd:COG0394    2 MPKRVLFVCTGNICRSPMAEALLRHL-----AGGRVEVDSAGTEP---GGPVDPRAVAVLAERGIDLSGhRSRQLDEEDL 73

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 754188141  95 ENFDLILAMDKANYQDILSLdrtgkYQEKVKLMCDYaryhpekEVPDPYYGGREGFDRVIELLLDSCGSLLEEVK 169
Cdd:COG0394   74 PEFDLVITMCDSAAEELCPL-----FPGAAKLLLHW-------DVPDPYYGGLEAFREVRDEIERRIEALLAKLR 136
LMWPc smart00226
Low molecular weight phosphatase family;
20-166 1.10e-34

Low molecular weight phosphatase family;


Pssm-ID: 197586  Cd Length: 134  Bit Score: 118.34  E-value: 1.10e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754188141    20 LLFVCLGNICRSPAAENIMtylieQEGLGNKILCDSAGTAGYhIGSPPDSRMNTAAKKRGIPLQGTARQFTREDFENFDL 99
Cdd:smart00226   1 ILFVCTGNICRSPMAEALF-----KAYVGDRVKIDSAGTGAW-VGGGADPRAVKVLKEHGIDLSHHASQLTSSDFKNADL 74

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 754188141   100 ILAMDKANYQDILSLdrTGKYQEKVKLMCDYAryhpekEVPDPYYGGREGFDRVIELLLDSCGSLLE 166
Cdd:smart00226  75 VLAMDGSHLRNICRL--KPPSRAKVELFGHYV------DVDDPYYGGIDGFERVYDELENALQEFLK 133
LMWP cd00115
Low molecular weight phosphatase family; Low molecular weight phosphatases (LMWPs) are a group ...
 20-157 4.26e-27

Low molecular weight phosphatase family; Low molecular weight phosphatases (LMWPs) are a group of small soluble enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). This family includes protein tyrosine phosphatases, arginine phosphatases and arsenate reductases.


Pssm-ID: 319970  Cd Length: 137  Bit Score: 99.10  E-value: 4.26e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754188141  20 LLFVCLGNICRSPAAENIMTYLIEQEglgNKIlcDSAGTAGYHiGSPPDSRMNTAAKKRGIPLQGTARQFTREDFENFDL 99
Cdd:cd00115    2 ILFICTGNICRSPMAEAIFKQLLGDE---WKV--DSAGTGAHH-GEGADPRAVRVLKEVGIDISHRSDQIKSEHLDNYDL 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 754188141 100 ILAMDKANYQDILSL---DRTGKYQEKVKLMcdyaryhpEKEVPDPYYGGREGFDRVIELL 157
Cdd:cd00115   76 VLVMDGSNLDKIPRIfpeARGKTWLPHVKLE--------HGEIDDPYRGDIEDFRRVRDEL 128
LMWPAP cd16344
low molecular weight protein arginine phosphatase; Low molecular weight protein arginine ...
 18-159 1.74e-22

low molecular weight protein arginine phosphatase; Low molecular weight protein arginine phosphatases are part of the low molecular weight phosphatase (LMWP) family. They share a highly conserved active site motif (V/I)CXGNTCRS. It has been shown that the conserved threonine, which in many LMWPTPs is an isoleucine, confers specificity to phosphoarginine over phosphotyrosine.


Pssm-ID: 319972  Cd Length: 142  Bit Score: 87.49  E-value: 1.74e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754188141  18 YKLLFVCLGNICRSPAAENIMTYLIEQEGlgnkILCDSAGTAGYHiGSPPDSrmNTAA--KKRGIPLQG-TARQFTREDF 94
Cdd:cd16344    1 MKILFVCTGNTCRSPMAEAILKKLLEELD----VEVKSAGIFAVD-GSPASP--NAVEvlKEKGIDLSGhRSQQLTEELL 73

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 754188141  95 ENFDLILAMDKANYQDILSLDrtGKYQEKVKLMCDYArYHPEKEVPDPyYGG-----REGFD---RVIELLLD 159
Cdd:cd16344   74 EWADLILTMTESHKQALLSLY--PEAADKVFTLKEYV-GGEDGDISDP-FGGslevyRQTAEeleELIEKLLK 142
etp PRK11391
phosphotyrosine-protein phosphatase; Provisional
 20-157 2.53e-18

phosphotyrosine-protein phosphatase; Provisional


Pssm-ID: 138553  Cd Length: 144  Bit Score: 76.60  E-value: 2.53e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754188141  20 LLFVCLGNICRSPAAENimtyLIEQEGLGNKIlcDSAGTAGYhIGSPPDSRMNTAAKKRGIPLQG-TARQFTREDFENFD 98
Cdd:PRK11391   5 ILVVCTGNICRSPIGER----LLRKRLPGVKV--KSAGVHGL-VKHPADATAADVAANHGVSLEGhAGRKLTAEMARNYD 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 754188141  99 LILAMDKANYQDILSLdrTGKYQEKVKLmcdYARYHPEKEVPDPYYGGREGFDRVIELL 157
Cdd:PRK11391  78 LILAMESEHIAQVTAI--APEVRGKTML---FGQWLEQKEIPDPYRKSQDAFEHVYGML 131
PRK10126 PRK10126
low molecular weight protein-tyrosine-phosphatase Wzb;
16-157 2.81e-18

low molecular weight protein-tyrosine-phosphatase Wzb;


Pssm-ID: 182256  Cd Length: 147  Bit Score: 76.49  E-value: 2.81e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754188141  16 MPYKLLFVCLGNICRSPAAENIM-TYLIEqeglgnkILCDSAGTaGYHIGSPPDSRMNTAAKKRGIPLQG-TARQFTRED 93
Cdd:PRK10126   1 MFNNILVVCVGNICRSPTAERLLqRYHPE-------LKVESAGL-GALVGKGADPTAISVAAEHQLSLEGhCARQISRRL 72

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 754188141  94 FENFDLILAMDKANYQDILSLdrTGKYQEKVKLmcdYARYHPEKEVPDPYYGGREGFDRVIELL 157
Cdd:PRK10126  73 CRNYDLILTMEKRHIERLCEM--APEMRGKVML---FGHWDNECEIPDPYRKSREAFEAVYTLL 131
COG4551 COG4551
Predicted protein tyrosine phosphatase [General function prediction only];
19-116 1.66e-04

Predicted protein tyrosine phosphatase [General function prediction only];


Pssm-ID: 443615  Cd Length: 109  Bit Score: 39.05  E-value: 1.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754188141  19 KLLFVCLGNICRSPAAENIMTyliEQEGlgnkILCDSAGTAgyhigspPDSRmntaakkrgIPLqgtarqfTREDFENFD 98
Cdd:COG4551    3 NVLFVCSRNRWRSPTAEQVFR---NHPG----VEVRSAGTS-------PDAR---------VPV-------TAELIEWAD 52

                         90       100
                 ....*....|....*....|....*
gi 754188141  99 LILAMDK-------ANYQDILSLDR 116
Cdd:COG4551   53 VIFVMEKkhrnrlsKRFGRLLKGKR 77
LMWP_ArsC cd16345
Arsenate reductase of the LMWP family; Arsenate reductase plays an important role in the ...
 19-107 5.90e-03

Arsenate reductase of the LMWP family; Arsenate reductase plays an important role in the reduction of intracellular arsenate to arsenite, an important step in arsenic detoxification. The reduction involves three different thiolate nucleophiles. In arsenate reductases of the LMWP family, reduction can be coupled with thioredoxin (Trx)/thioredoxin reductase (TrxR) or glutathione (GSH)/glutaredoxin (Grx).


Pssm-ID: 319973  Cd Length: 132  Bit Score: 35.12  E-value: 5.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754188141  19 KLLFVCLGNICRSPAAENIMTYLieqegLGNKILCDSAGTAgyhigsPpdSRMNTAAKK----RGIPlqgTARQFTR--E 92
Cdd:cd16345    1 KVLFLCTGNSARSQMAEALLRHL-----GGDRFEAYSAGSE------P--AGVNPLAIEvmkeIGID---ISGQRSKslD 64

                         90
                 ....*....|....*...
gi 754188141  93 DF--ENFDLILAM-DKAN 107
Cdd:cd16345   65 EFlgQEFDYVITVcDNAA 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH