NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|752619255|ref|WP_041288616|]
View 

RND family transporter [Kosmotoga olearia]

Protein Classification

RND family transporter( domain architecture ID 11437099)

resistance-nodulation-cell division (RND) family transporter similar to Methanocaldococcus jannaschii membrane protein MJ1562

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
1-791 3.51e-77

Predicted exporter protein, RND superfamily [General function prediction only];


:

Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 265.18  E-value: 3.51e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255   1 MQKLSRFVFTYRVPIVVFFVVISAIGFYLSTNLVVDSDLLKLLPRESDVVKRYENFVKWSSTDDVTFIVLKTNNK--TQK 78
Cdd:COG1033    4 MERLARFILRHRKLVLLLFLLLTLLLAYGAPKLEVDTDFESLLPEDDPSVQAYDEFEEEFGGDDTVVVAVEGKDDifTPE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255  79 GLDELKAAAKKLYQdsytFPHIEDFIRfdlLSNLGALSLVlVDPSVLKELSPEEFDFSDEfkrlvnyDFSAIHDigiAFS 158
Cdd:COG1033   84 TLEALRELTEELEE----IPGVDSVTS---LTNVRATEGT-EDGLTVEPLIPDELPASPE-------ELAELRE---KVL 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255 159 ETLQLKDKILSDSTTTfesfvripsefpendpMILVMGIKLDGPSSDVDYVDlVIPQLRKWVKsEISEYNISFNLTGDHQ 238
Cdd:COG1033  146 SSPLYVGRLVSPDGKA----------------TLIVVTLDPDPLSSDLDRKE-VVAEIRAIIA-KYEDPGVEVYLTGFPV 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255 239 ATYESHKQASRDFMVTTIVSLIGIALLFYLAYSSFKVTMYIFISLATSMFTTLGLAFLIFGRLNIVTTFVNAITLGLGID 318
Cdd:COG1033  208 LRGDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTILVPPLLLAIGID 287

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255 319 YGIHIITRLSDEVKRRRDPVLSLKHTYYAVTKPLLVSLLTTILVFILLAIIDSPAIRELGILTSVGLFVFFITMYIFLPA 398
Cdd:COG1033  288 YGIHLLNRYREERRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLPA 367

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255 399 -LSIGSFLKPGKVMKIH--SLDRFFYATSAVVKRYSMISLsIIVTILLIFSYIGFVSIsNFSYTPPGLMSEESEMLSTLH 475
Cdd:COG1033  368 lLSLLPRPKPKTRRLKKppELGRLLAKLARFVLRRPKVIL-VVALVLAVVSLYGISRL-KVEYDFEDYLPEDSPIRQDLD 445

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255 476 LLERVFKAdvTNSVPILAD-----------NIEQVEEISRILDENEYVEGSFSILTIfkedsdeyMKQFKEVVRtldrfR 544
Cdd:COG1033  446 FIEENFGG--SDPLEVVVDtgepdglkdpeVLKEIDRLQDYLESLPEVGKVLSLADL--------VKELNQALN-----E 510

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255 545 GNPlmeaflkkanyydELFVLLDESEKIEsgkeLIDFISETLPESLKKQFIylSPDGKkYYIVTAYPAAHlySSNFIKRF 624
Cdd:COG1033  511 GDP-------------KYYALPESRELLA----QLLLLLSSPPGDDLSRFV--DEDYS-AARVTVRLKDL--DSEEIKAL 568

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255 625 FDSLGELVE----------RVEGYPRIFYYIMDIIKKVSLPVSGVAILLVFLIVSLERKNIFDGLKVTFLMIGILLSMFG 694
Cdd:COG1033  569 VEEVRAFLAenfppdgvevTLTGSAVLFAAINESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFG 648

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255 695 IMNLIGIKTTFITIITAPLIIGIGVDSLVHMIH-----SSTTYNLFEA-----GRTLKSVTMSSATTMLAFFSFSLAEGR 764
Cdd:COG1033  649 LMGLLGIPLNIATAVVASIALGIGVDYTIHFLSryreeRRKGGDLEEAirralRTTGKAILFTSLTLAAGFGVLLFSSFP 728

                        810       820
                 ....*....|....*....|....*..
gi 752619255 765 LLRNFGLTLTVGVFLALLVAAFAIPVL 791
Cdd:COG1033  729 PLADFGLLLALGLLVALLAALLLLPAL 755
 
Name Accession Description Interval E-value
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
1-791 3.51e-77

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 265.18  E-value: 3.51e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255   1 MQKLSRFVFTYRVPIVVFFVVISAIGFYLSTNLVVDSDLLKLLPRESDVVKRYENFVKWSSTDDVTFIVLKTNNK--TQK 78
Cdd:COG1033    4 MERLARFILRHRKLVLLLFLLLTLLLAYGAPKLEVDTDFESLLPEDDPSVQAYDEFEEEFGGDDTVVVAVEGKDDifTPE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255  79 GLDELKAAAKKLYQdsytFPHIEDFIRfdlLSNLGALSLVlVDPSVLKELSPEEFDFSDEfkrlvnyDFSAIHDigiAFS 158
Cdd:COG1033   84 TLEALRELTEELEE----IPGVDSVTS---LTNVRATEGT-EDGLTVEPLIPDELPASPE-------ELAELRE---KVL 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255 159 ETLQLKDKILSDSTTTfesfvripsefpendpMILVMGIKLDGPSSDVDYVDlVIPQLRKWVKsEISEYNISFNLTGDHQ 238
Cdd:COG1033  146 SSPLYVGRLVSPDGKA----------------TLIVVTLDPDPLSSDLDRKE-VVAEIRAIIA-KYEDPGVEVYLTGFPV 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255 239 ATYESHKQASRDFMVTTIVSLIGIALLFYLAYSSFKVTMYIFISLATSMFTTLGLAFLIFGRLNIVTTFVNAITLGLGID 318
Cdd:COG1033  208 LRGDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTILVPPLLLAIGID 287

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255 319 YGIHIITRLSDEVKRRRDPVLSLKHTYYAVTKPLLVSLLTTILVFILLAIIDSPAIRELGILTSVGLFVFFITMYIFLPA 398
Cdd:COG1033  288 YGIHLLNRYREERRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLPA 367

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255 399 -LSIGSFLKPGKVMKIH--SLDRFFYATSAVVKRYSMISLsIIVTILLIFSYIGFVSIsNFSYTPPGLMSEESEMLSTLH 475
Cdd:COG1033  368 lLSLLPRPKPKTRRLKKppELGRLLAKLARFVLRRPKVIL-VVALVLAVVSLYGISRL-KVEYDFEDYLPEDSPIRQDLD 445

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255 476 LLERVFKAdvTNSVPILAD-----------NIEQVEEISRILDENEYVEGSFSILTIfkedsdeyMKQFKEVVRtldrfR 544
Cdd:COG1033  446 FIEENFGG--SDPLEVVVDtgepdglkdpeVLKEIDRLQDYLESLPEVGKVLSLADL--------VKELNQALN-----E 510

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255 545 GNPlmeaflkkanyydELFVLLDESEKIEsgkeLIDFISETLPESLKKQFIylSPDGKkYYIVTAYPAAHlySSNFIKRF 624
Cdd:COG1033  511 GDP-------------KYYALPESRELLA----QLLLLLSSPPGDDLSRFV--DEDYS-AARVTVRLKDL--DSEEIKAL 568

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255 625 FDSLGELVE----------RVEGYPRIFYYIMDIIKKVSLPVSGVAILLVFLIVSLERKNIFDGLKVTFLMIGILLSMFG 694
Cdd:COG1033  569 VEEVRAFLAenfppdgvevTLTGSAVLFAAINESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFG 648

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255 695 IMNLIGIKTTFITIITAPLIIGIGVDSLVHMIH-----SSTTYNLFEA-----GRTLKSVTMSSATTMLAFFSFSLAEGR 764
Cdd:COG1033  649 LMGLLGIPLNIATAVVASIALGIGVDYTIHFLSryreeRRKGGDLEEAirralRTTGKAILFTSLTLAAGFGVLLFSSFP 728

                        810       820
                 ....*....|....*....|....*..
gi 752619255 765 LLRNFGLTLTVGVFLALLVAAFAIPVL 791
Cdd:COG1033  729 PLADFGLLLALGLLVALLAALLLLPAL 755
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
 233-797 1.96e-32

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 135.12  E-value: 1.96e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255  233 LTGDHQATYESHKQASRDFMVTTIVSLIGIALLFYLAYSSFKVTMYIFISLATSMFTTLGLAFLIFGRLNIVTTFVNAIT 312
Cdd:TIGR03480 253 LTGEVALSDEELATVSEGATVAGLLSFVLVLVLLWLALRSPRLVFAVLVTLIVGLILTAAFATLAVGHLNLISVAFAVLF 332

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255  313 LGLGIDYGIHIITRLSDEVKRRRDPVLSLKHTYYAVTKPLLVSLLTTILVFILLAIIDSPAIRELGILTSVGLFVFFITM 392
Cdd:TIGR03480 333 IGLGVDFAIQFSLRYREERFRGGNHREALSVAARRMGAALLLAALATAAGFFAFLPTDYKGVSELGIIAGTGMFIALFVT 412

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255  393 YIFLPALSigSFLKP--------GKVMKihSLDRFFYATSAVVkrysmislsIIVTILLIFSYIGFVSISNFSYTPPGLM 464
Cdd:TIGR03480 413 LTVLPALL--RLLRPprrrkppgYATLA--PLDAFLRRHRRPV---------LGVTLILGIAALALLPQLRFDFNPLNLQ 479

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255  465 SEESEMLSTLHLLERVFKADVtNSVPILADNIEQVEEISRILDENEYVEGSFSILTIFKEDSDEYMKQFKEVVRTLDRFR 544
Cdd:TIGR03480 480 DPKTESVRTFLELLADPDTSP-YSAEVLAPSAPEARALTERLEALPEVDQVVTLPDFVPDDQEAKLALIADLALVLGPTL 558

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255  545 G----------NPLMEAFLKKANYYDEL------------FVLLDE----SEKIESGKELIDFIS--------------- 583
Cdd:TIGR03480 559 NpgeadpapsaEEVAAALRRLAARLRAAaaksqdpdaaaaGRLAASldrlLAKAPAQAATLRALQgallaglpgeldrlr 638

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255  584 ----------ETLPESLKKQFIylSPDGKkyYIVTAYPAAHLYSSNFIKRFFDSLGELVERVEGYPRIFYYIMDIIKKVS 653
Cdd:TIGR03480 639 dslqaepvtlEDLPPDLRRRWV--AKDGR--ARLEVFPKEDLNDNEALRRFVRAVRKVAPDATGAPVSILESGDTVVGAF 714

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255  654 LPVSGVAILL--VFLIVSLERKnifdgLKVTFLMIGILLS---MFGIMNLIGIKTTFITIITAPLIIGIGVDSLVHMIHS 728
Cdd:TIGR03480 715 LQAFIYALVAitVLLLLTLRRV-----RDVLLVLAPLLLAgllTVAAMVLLGIPFNFANIIALPLLLGLGVDFGIYMVHR 789

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 752619255  729 S----TTYNLFeAGRTLKSVTMSSATTMLAFFSFSLAEGRLLRNFGLTLTVGVFLALLVAAFAIPVLPWNKER 797
Cdd:TIGR03480 790 WrngvDSGNLL-QSSTARAVFFSALTTATAFGSLAVSSHPGTASMGILLSLGLGLTLLCTLIFLPALLGKRRR 861
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
 232-399 1.32e-13

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 72.71  E-value: 1.32e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255  232 NLTGDHQATYESHKQASRDFMVTTIVSLIGIALLFYLAYSSFKVTMYIFISLATSMFTTLGLA-----FLIFGRLNIVTT 306
Cdd:pfam03176 125 YLTGPAATVADLRDAGDRDLGLIEAVTLVVIFIILLIVYRSVVAALLPLLTVGLSLGAAQGLVailahILGIGLSTFALN 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255  307 FVNAITLGLGIDYGIHIITRLSDEVKRRRDPVLSLKHTYYAVTKPLLVSLLTTILVFILLAIIDSPAIRELGILTSVGLF 386
Cdd:pfam03176 205 LLVVLLIAVGTDYALFLVSRYREELRAGEDREEAVIRAVRGTGKVVTAAGLTVAIAMLALSFARLPVFAQVGPTIAIGVL 284

                         170
                  ....*....|...
gi 752619255  387 VFFITMYIFLPAL 399
Cdd:pfam03176 285 VDVLAALTLLPAL 297
 
Name Accession Description Interval E-value
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
1-791 3.51e-77

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 265.18  E-value: 3.51e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255   1 MQKLSRFVFTYRVPIVVFFVVISAIGFYLSTNLVVDSDLLKLLPRESDVVKRYENFVKWSSTDDVTFIVLKTNNK--TQK 78
Cdd:COG1033    4 MERLARFILRHRKLVLLLFLLLTLLLAYGAPKLEVDTDFESLLPEDDPSVQAYDEFEEEFGGDDTVVVAVEGKDDifTPE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255  79 GLDELKAAAKKLYQdsytFPHIEDFIRfdlLSNLGALSLVlVDPSVLKELSPEEFDFSDEfkrlvnyDFSAIHDigiAFS 158
Cdd:COG1033   84 TLEALRELTEELEE----IPGVDSVTS---LTNVRATEGT-EDGLTVEPLIPDELPASPE-------ELAELRE---KVL 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255 159 ETLQLKDKILSDSTTTfesfvripsefpendpMILVMGIKLDGPSSDVDYVDlVIPQLRKWVKsEISEYNISFNLTGDHQ 238
Cdd:COG1033  146 SSPLYVGRLVSPDGKA----------------TLIVVTLDPDPLSSDLDRKE-VVAEIRAIIA-KYEDPGVEVYLTGFPV 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255 239 ATYESHKQASRDFMVTTIVSLIGIALLFYLAYSSFKVTMYIFISLATSMFTTLGLAFLIFGRLNIVTTFVNAITLGLGID 318
Cdd:COG1033  208 LRGDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTILVPPLLLAIGID 287

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255 319 YGIHIITRLSDEVKRRRDPVLSLKHTYYAVTKPLLVSLLTTILVFILLAIIDSPAIRELGILTSVGLFVFFITMYIFLPA 398
Cdd:COG1033  288 YGIHLLNRYREERRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLPA 367

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255 399 -LSIGSFLKPGKVMKIH--SLDRFFYATSAVVKRYSMISLsIIVTILLIFSYIGFVSIsNFSYTPPGLMSEESEMLSTLH 475
Cdd:COG1033  368 lLSLLPRPKPKTRRLKKppELGRLLAKLARFVLRRPKVIL-VVALVLAVVSLYGISRL-KVEYDFEDYLPEDSPIRQDLD 445

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255 476 LLERVFKAdvTNSVPILAD-----------NIEQVEEISRILDENEYVEGSFSILTIfkedsdeyMKQFKEVVRtldrfR 544
Cdd:COG1033  446 FIEENFGG--SDPLEVVVDtgepdglkdpeVLKEIDRLQDYLESLPEVGKVLSLADL--------VKELNQALN-----E 510

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255 545 GNPlmeaflkkanyydELFVLLDESEKIEsgkeLIDFISETLPESLKKQFIylSPDGKkYYIVTAYPAAHlySSNFIKRF 624
Cdd:COG1033  511 GDP-------------KYYALPESRELLA----QLLLLLSSPPGDDLSRFV--DEDYS-AARVTVRLKDL--DSEEIKAL 568

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255 625 FDSLGELVE----------RVEGYPRIFYYIMDIIKKVSLPVSGVAILLVFLIVSLERKNIFDGLKVTFLMIGILLSMFG 694
Cdd:COG1033  569 VEEVRAFLAenfppdgvevTLTGSAVLFAAINESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFG 648

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255 695 IMNLIGIKTTFITIITAPLIIGIGVDSLVHMIH-----SSTTYNLFEA-----GRTLKSVTMSSATTMLAFFSFSLAEGR 764
Cdd:COG1033  649 LMGLLGIPLNIATAVVASIALGIGVDYTIHFLSryreeRRKGGDLEEAirralRTTGKAILFTSLTLAAGFGVLLFSSFP 728

                        810       820
                 ....*....|....*....|....*..
gi 752619255 765 LLRNFGLTLTVGVFLALLVAAFAIPVL 791
Cdd:COG1033  729 PLADFGLLLALGLLVALLAALLLLPAL 755
COG4258 COG4258
Predicted exporter [General function prediction only];
192-789 1.26e-34

Predicted exporter [General function prediction only];


Pssm-ID: 443400 [Multi-domain]  Cd Length: 783  Bit Score: 141.53  E-value: 1.26e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255 192 ILVMgIKLDGPSSDVDYVDLVIPQLRKWVKSEISEY-NISFNLTGDHQATYESHKQASRDFMVTTIVSLIGIALLFYLAY 270
Cdd:COG4258  192 ALLL-AETRASGFDTDAQQQLVAALRAAFAALNAAFpGAQLLLTGAGLFAVAAAQQIKHDISTIGLISLLGILLLLLLVF 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255 271 SSFKVTMYIFISLATSMFTTLGLAFLIFGRLNIVTTFVNAITLGLGIDYGIHIITrlsdevKRRRDPVLSLKHTYYAVTK 350
Cdd:COG4258  271 RSLRPLLLGLLPVAVGALAGLAAVSLVFGSVHGITLGFGSSLIGVAVDYSLHYLT------HRRAAGEWDPRAALRRIWP 344

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255 351 PLLVSLLTTILVFILLAIIDSPAIRELGILTSVGLFVFFITMYIFLPALsigsfLKPGKVMKIHSLDRFFYATSAVVKRY 430
Cdd:COG4258  345 TLLLGLLTTVLGYLALLFSPFPGLRQLGVFAAAGLLAAALTTLLWLPLL-----LPRAAPRPPAPALALLARLLARWPRR 419

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255 431 SMISLSIIVtILLIFSYIGFV------SISNFSYTPPGLMSEESEmlstlhlLERVFKADVTNSVPIL-ADNIEQV---- 499
Cdd:COG4258  420 LRWLLALLA-VLALASLLGLNrlkwndDLRALNPVPAALLAQEAR-------LRALLGAPDVSQYLVVyGPDAEQAlqrn 491

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255 500 EEISRILD---ENEYVEGSFSILTIFKedSDEYMKQFKEVVRTLDRFRgnPLMEAFLKKANYYDELFVLLDESEKIESGK 576
Cdd:COG4258  492 EALLPRLDalvAQGAIAGYQSLSRLLP--SAATQQARQALLPDLAALR--PRLAEALAGLGFRPDAFAPFLADLEAARAA 567

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255 577 ELIDfISETLPESLKKQFIYL---SPDGKKYYIVTAYPAAHlysSNFIKRFFDSLGE--LVERVEGYPRIF-YYIMDIIK 650
Cdd:COG4258  568 PPLT-PEDLLASPLAAALRLLllgRKDGQWAALVPLRGVDD---AAALRAAAAGLPGvrLVDRKAESSSLFgRYRNDALW 643

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255 651 kvslpVSGVAILLVFLIVSLERKNIFDGLKV-------TFLMIGIL------LSMFGIMNLIgikttfitiitapLIIGI 717
Cdd:COG4258  644 -----LLLLALLLILLLLLLRLRSLRRALRVllppllaVLLTLAILgllgipLNLFHLIALL-------------LVLGI 705

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255 718 GVDslvhmihssttYNLF---------EAGRTLKSVTMSSATTMLAFFSFSLAEGRLLRNFGLTLTVGVFLALLVAAFAI 788
Cdd:COG4258  706 GID-----------YALFfteglldkgELARTLLSILLAALTTLLGFGLLAFSSTPALRSFGLTVLLGILLALLLAPLLA 774


                 .
gi 752619255 789 P 789
Cdd:COG4258  775 P 775
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
 233-797 1.96e-32

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 135.12  E-value: 1.96e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255  233 LTGDHQATYESHKQASRDFMVTTIVSLIGIALLFYLAYSSFKVTMYIFISLATSMFTTLGLAFLIFGRLNIVTTFVNAIT 312
Cdd:TIGR03480 253 LTGEVALSDEELATVSEGATVAGLLSFVLVLVLLWLALRSPRLVFAVLVTLIVGLILTAAFATLAVGHLNLISVAFAVLF 332

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255  313 LGLGIDYGIHIITRLSDEVKRRRDPVLSLKHTYYAVTKPLLVSLLTTILVFILLAIIDSPAIRELGILTSVGLFVFFITM 392
Cdd:TIGR03480 333 IGLGVDFAIQFSLRYREERFRGGNHREALSVAARRMGAALLLAALATAAGFFAFLPTDYKGVSELGIIAGTGMFIALFVT 412

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255  393 YIFLPALSigSFLKP--------GKVMKihSLDRFFYATSAVVkrysmislsIIVTILLIFSYIGFVSISNFSYTPPGLM 464
Cdd:TIGR03480 413 LTVLPALL--RLLRPprrrkppgYATLA--PLDAFLRRHRRPV---------LGVTLILGIAALALLPQLRFDFNPLNLQ 479

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255  465 SEESEMLSTLHLLERVFKADVtNSVPILADNIEQVEEISRILDENEYVEGSFSILTIFKEDSDEYMKQFKEVVRTLDRFR 544
Cdd:TIGR03480 480 DPKTESVRTFLELLADPDTSP-YSAEVLAPSAPEARALTERLEALPEVDQVVTLPDFVPDDQEAKLALIADLALVLGPTL 558

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255  545 G----------NPLMEAFLKKANYYDEL------------FVLLDE----SEKIESGKELIDFIS--------------- 583
Cdd:TIGR03480 559 NpgeadpapsaEEVAAALRRLAARLRAAaaksqdpdaaaaGRLAASldrlLAKAPAQAATLRALQgallaglpgeldrlr 638

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255  584 ----------ETLPESLKKQFIylSPDGKkyYIVTAYPAAHLYSSNFIKRFFDSLGELVERVEGYPRIFYYIMDIIKKVS 653
Cdd:TIGR03480 639 dslqaepvtlEDLPPDLRRRWV--AKDGR--ARLEVFPKEDLNDNEALRRFVRAVRKVAPDATGAPVSILESGDTVVGAF 714

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255  654 LPVSGVAILL--VFLIVSLERKnifdgLKVTFLMIGILLS---MFGIMNLIGIKTTFITIITAPLIIGIGVDSLVHMIHS 728
Cdd:TIGR03480 715 LQAFIYALVAitVLLLLTLRRV-----RDVLLVLAPLLLAgllTVAAMVLLGIPFNFANIIALPLLLGLGVDFGIYMVHR 789

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 752619255  729 S----TTYNLFeAGRTLKSVTMSSATTMLAFFSFSLAEGRLLRNFGLTLTVGVFLALLVAAFAIPVLPWNKER 797
Cdd:TIGR03480 790 WrngvDSGNLL-QSSTARAVFFSALTTATAFGSLAVSSHPGTASMGILLSLGLGLTLLCTLIFLPALLGKRRR 861
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 11-791 5.63e-29

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 123.79  E-value: 5.63e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255   11 YRVPIVVFFVVISAIGFYLSTNLVVDSDLLKLLPRESDVVKRYENFVK--WSSTDDVtFIVLKTNNKTQKgldELKAAAK 88
Cdd:TIGR00921   3 FRTAIILVFLALLILSAYGAQHLNVESDTEKQLPKDFESYKWYHVLQRefGTSTKTL-LVVIEGDDVTRK---PVLDYMR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255   89 KLYQDSYTFPHIED-FIRFDLLSNLGALSLVlvdPSVLKELSPEEFDFSDEFKRLVNYDFS-AIHDIGIAFSETLQLKDK 166
Cdd:TIGR00921  79 RLEQRLREKPYVTNvRSAADIMRQIPGNFPL---PVTMPEVRPLMSEYPRSKEMFLSKDHTvAIIIVQLKSDADYKQVVP 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255  167 ILSDstttfesfVRIPSEFPENDPmilvmGIKLDgpssdvdyvdlvipqlrkwvkseiseynisfnLTGDHQATYESHKQ 246
Cdd:TIGR00921 156 IYND--------VERSLERTNPPS-----GKFLD--------------------------------VTGSPAINYDIERE 190

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255  247 ASRDFMVTTIVSLIGIALLFYLAYSSFKVTMYIFISLATSMFTTLGLAFLIFGRLNIVTTFVNAITLGLGIDYGIHIITR 326
Cdd:TIGR00921 191 FGKDMGTTMAISGILVVLVLLLDFKRWWRPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTLNR 270

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255  327 LSDEVKRRRDPVLSLKHTYYAVTKPLLVSLLTTILVFILLAIIDSPAIRELGILTSVGLFVFFITMYIFLPALSIGSFLK 406
Cdd:TIGR00921 271 YEEERDIGRAKGEAIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALLQSIDIG 350

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255  407 PGKVMKIHSLDRffYATSAVVKRYSMISLSII---VTILLIFSYIGFVSIsnfsYTPPGLMSEesemlstlhllervfkA 483
Cdd:TIGR00921 351 REKVKKEIIAIG--GKSSEIEEELSKVLSITVrhpVPALVAALIITGLGL----YGAAGIKPE----------------V 408

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255  484 DVTNSVPILADNIEQVEEISRILDeneyveGSFSILTIFKEDSDEymkQFKEVVRTLDRFRGNPLMEAFLkkANYYDELF 563
Cdd:TIGR00921 409 NIEKFIPQDLPSLQARKVIESHMG------GSHDFATILVKADDV---RDPELVRFMDELSRDIKATGVA--ARVFGAPS 477

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255  564 VLLDESEKiESGKELIDFISETLPESLKKQfiYLSPDGKKYYIV------TAYPAAHLYSSNFIKRFFDSLGELVErVEG 637
Cdd:TIGR00921 478 IIDLVKEV-EGLPAPERSALEPIPEDEEGG--YISGGQIKVAVIqvqlkqGEPKVQGRKILRDVQHEHPPPGVKVG-VTG 553

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255  638 YPRIFYYIMDIIKKVSLPVSGVAILLVFLIVSLERKNIFDGLKVTFLMIGILLSMFGIMNLIGIKTTFITIITAPLIIGI 717
Cdd:TIGR00921 554 LPVAFAEMHELVNEGMRRMTIAGAILVLMILLAVFRNPIKAVFPLIAIGSGILWAIGLMGLRGIPSFLAMATTISIILGL 633

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255  718 GVDSLVHMI---------HSSTTYNLFEAGRTLKSVTMSSATTMLAFFSFSLAEGRLLRNFGLTLTVGVFLALLVAAFAI 788
Cdd:TIGR00921 634 GMDYSIHLAeryfeerkeHGPKEAITHTMERTGPGILFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLSSLTAALVVF 713


                  ...
gi 752619255  789 PVL 791
Cdd:TIGR00921 714 PAL 716
actII TIGR00833
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ...
 233-447 4.13e-17

Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 129913 [Multi-domain]  Cd Length: 910  Bit Score: 86.18  E-value: 4.13e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255  233 LTGDHQATYESHKQASRDFMVTTIVSLIGIALLFYLAYSSFKVTMYIFISLATSMFTTLGLAFL--IFGRLNIVTT---F 307
Cdd:TIGR00833 157 VTGPLATIADILESGDKDMNRITATTGIIVLIILLLVYRSPITMLVPLVSVGFSVVVAQGIVSLlgIPGLIGVNAQttvL 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255  308 VNAITLGLGIDYGIHIITRLSDEVKRRRDPVLSLKHTYYAVTKPLLVSLLTTILVFILLAIIDSPAIRELGILTSVGLFV 387
Cdd:TIGR00833 237 LTALVIGAGTDYAVFLTGRYHEERRKGESLEEAAAEALRGTGKAILGSALTVAVAFLALSLARLPSFKTLGVSCAVGVLV 316

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 752619255  388 FFITMYIFLPAL-SIGS---FLKPGKVMKIHsldRFFYATSAVVKRYSMISLSIIVTILLIFSY 447
Cdd:TIGR00833 317 ALLNAVTLTPALlTLEGregLMKPGRKSKIR---FIWRRLGTAVVRRPWPILVTTLIISGVSLL 377
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
 197-494 1.63e-15

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 80.58  E-value: 1.63e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255 197 IKLDGPSSDVdyVDLVIPQLRKWVKsEISEYNISFNLTGDHQATYESHKQASRDFMVTTIVSLIGIALLFYLAYSSFkVT 276
Cdd:COG2409  120 VTLDGDAGDE--AAEAVDALRDAVA-AAPAPGLTVYVTGPAALAADLNEAFEEDLGRAELITLPVALVVLLLVFRSL-VA 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255 277 MyiFISLATSMFT---TLGLAFLIFGRLNI---VTTFVNAITLGLGIDYGIHIITRLSDEVKRRRDPVLSLKHTYYAVTK 350
Cdd:COG2409  196 A--LLPLLTAGLAvgvALGLLALLAAFTDVssfAPNLLTMLGLGVGIDYALFLVSRYREELRAGEDREEAVARAVATAGR 273

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255 351 PLLVSLLTTILVFILLAIIDSPAIRELGILTSVGLFVFFITMYIFLPA-LSI-GSFLKPGKVMKIHSLD----RFFYATS 424
Cdd:COG2409  274 AVLFSGLTVAIALLGLLLAGLPFLRSMGPAAAIGVAVAVLAALTLLPAlLALlGRRVFWPRRPRRRRAAapesGFWRRLA 353

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255 425 AVVKRYSMISLSIIVTILLIFSyIGFVSIsNFSYTPPGLMSEESEMLSTLHLLERVFKADVTNSVPILAD 494
Cdd:COG2409  354 RAVVRRPVPVLVAAVAVLLALA-LPALGL-RLGLPDADSLPADSPSRQGYDALAEHFPPGSNGPLTVVVE 421
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
 232-399 1.32e-13

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 72.71  E-value: 1.32e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255  232 NLTGDHQATYESHKQASRDFMVTTIVSLIGIALLFYLAYSSFKVTMYIFISLATSMFTTLGLA-----FLIFGRLNIVTT 306
Cdd:pfam03176 125 YLTGPAATVADLRDAGDRDLGLIEAVTLVVIFIILLIVYRSVVAALLPLLTVGLSLGAAQGLVailahILGIGLSTFALN 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255  307 FVNAITLGLGIDYGIHIITRLSDEVKRRRDPVLSLKHTYYAVTKPLLVSLLTTILVFILLAIIDSPAIRELGILTSVGLF 386
Cdd:pfam03176 205 LLVVLLIAVGTDYALFLVSRYREELRAGEDREEAVIRAVRGTGKVVTAAGLTVAIAMLALSFARLPVFAQVGPTIAIGVL 284

                         170
                  ....*....|...
gi 752619255  387 VFFITMYIFLPAL 399
Cdd:pfam03176 285 VDVLAALTLLPAL 297
COG4258 COG4258
Predicted exporter [General function prediction only];
257-398 3.61e-10

Predicted exporter [General function prediction only];


Pssm-ID: 443400 [Multi-domain]  Cd Length: 783  Bit Score: 63.72  E-value: 3.61e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255 257 VSLIGIALLFYLAYSSFKVTMYIFISLATSMFTTLGLAFLIFGRLNIVTTFVNAITLGLGIDYGIHIItrlsdevkRRRD 336
Cdd:COG4258  647 LALLLILLLLLLRLRSLRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHLIALLLVLGIGIDYALFFT--------EGLL 718

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 752619255 337 PVLSLKHTYYAVtkplLVSLLTTILVFILLAIIDSPAIRELGILTSVGLFVFFITMYIFLPA 398
Cdd:COG4258  719 DKGELARTLLSI----LLAALTTLLGFGLLAFSSTPALRSFGLTVLLGILLALLLAPLLAPR 776
actII TIGR00833
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ...
 233-398 7.29e-08

Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 129913 [Multi-domain]  Cd Length: 910  Bit Score: 56.13  E-value: 7.29e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255  233 LTGDHQATYESHKQASRDFMVTTIVSLIGIALLFYLAYSSFKVTMYIFISLATSMFTTLGLAFLIF------GRLNIVTT 306
Cdd:TIGR00833 728 LAGVSAVNRDLRDLVNSDLGLISIITLAIVFMILALLLRAPVAPIVLIGSVALSYLWALGLSVLAFqhilgaELHWSVLA 807

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255  307 FVNAITLGLGIDYGIHIITRLSDEVKR-RRDPVLSlkhTYYAVTKPLLVSLLTTILVFILLAIIDSPAIRELGILTSVGL 385
Cdd:TIGR00833 808 GVFVLLVALGVDYNMLLVSRIKEESPAgNRTGIIR---ALGSTGGVITAAGLVFAGTMAALASAQLTAIAQFGFTVGVGI 884

                         170
                  ....*....|...
gi 752619255  386 FVFFITMYIFLPA 398
Cdd:TIGR00833 885 LLDTFIVRSVTVP 897
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
 179-399 1.96e-06

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 51.30  E-value: 1.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255 179 VRIPSEFPENDPMILVMGIKLDGPSSDVDYVDLViPQLRKWVKSEIseYNISFNLTGDHQATYESHKQASRDFMVTTIVS 258
Cdd:COG2409  450 VQPPTRPEGTDGDAARLQVVPDGDPDSPEAIDLV-DRLRDAAAPAL--EGAEVLVGGTTAVNIDISDALADDLPLVIPVV 526

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255 259 LIGIALLFYLAYSSFKVTMYIFISLATSMFTTLGLAFLIF----GRLNIVTTFVN--------AITLGLGIDYGIHIITR 326
Cdd:COG2409  527 LGLIFLLLLLLFRSVVAPLKAVLTNLLSLGAALGVLVLVFqhgwLLLGFTPGPLDsfvplllfVILFGLGMDYEVFLVSR 606

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 752619255 327 LSDEVKRRRDPVLSLKHTyYAVTKPLLVSL-LTTILVFILLAIIDSPAIRELGILTSVGLFV--FFITMyIFLPAL 399
Cdd:COG2409  607 IREEYDRGGGTREAVIRG-LARTGRVITSAaLIMAAVFAAFATSPLVFLKQIGFGLAVGVLLdaFVVRM-LLVPAL 680
AcrB COG0841
Multidrug efflux pump subunit AcrB [Defense mechanisms];
190-518 1.70e-05

Multidrug efflux pump subunit AcrB [Defense mechanisms];


Pssm-ID: 440603 [Multi-domain]  Cd Length: 1015  Bit Score: 48.56  E-value: 1.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255  190 PMILvMGIKLDGPSSDVDYVDLV---IPQLRKWVKSEIsEYNISFNLTGDHQATYEShkqasrdfMVTTIvsLIGIALLF 266
Cdd:COG0841   278 PAVG-LAIQKQPGANALEVADAVrakLEELQASLPEGV-ELTIVYDQSEFIRASIEE--------VVKTL--LEAILLVV 345

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255  267 ---YLAYSSFKVTMYIFISLATSMFTTLGLaFLIFGR-LNIVTTFvnAITLGLGI--DYGIHIItrlsdE-VKRRRDPVL 339
Cdd:COG0841   346 lvvFLFLRSWRATLIPAVAIPVSLIGTFAV-MYLLGFsLNILTLF--ALVLAIGIvvDDAIVVV-----EnIERHMEEGL 417

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255  340 SLKHTYYA----VTKPLLVSLLTTILVFILLAIIDSPA---IRELGILTSVGLFVFFITMYIFLPALSiGSFLKPGKVMK 412
Cdd:COG0841   418 SPLEAAIKgareVAGAVIASTLTLVAVFLPLAFMGGITgqlFRQFALTVAIALLISLFVALTLTPALC-ARLLKPHPKGK 496

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752619255  413 IHSLDRFFYAT-SAVVKRY-SMISLSIIVTILLIFSYIGFV--SISNFSYTPPGLM-SEESEMLSTlhllerVFKADVTN 487
Cdd:COG0841   497 KGRFFRAFNRGfDRLTRGYgRLLRWALRHRKLTLLVALALLalSVLLFGRLPTEFFpEEDQGQIIV------SVQLPPGT 570

                         330       340       350
                  ....*....|....*....|....*....|.
gi 752619255  488 SvpiLADNIEQVEEISRILDENEYVEGSFSI 518
Cdd:COG0841   571 S---LERTEAVVRQVEEILLEVPEVESVFSV 598
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH