NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|738298318|ref|WP_036251567|]
View 

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase, partial [Methylibium sp. T29]

Protein Classification

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase( domain architecture ID 11433680)

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein

CATH:  3.90.190.20|3.40.1190.10|3.40.1390.10
EC:  6.3.2.10
Gene Ontology:  GO:0005524|GO:0009252|GO:0047480|GO:0071555
PubMed:  16934839
SCOP:  4000234

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MurF COG0770
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 3-397 1.75e-154

UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


:

Pssm-ID: 440533 [Multi-domain]  Cd Length: 451  Bit Score: 443.39  E-value: 1.75e-154
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318   3 VMMDLRLAHALLpGSTLVGDPATPLLRVHSDTRTLRAGDLFVALKGERFDAHDFLPQARAAGAVAAIAEHGLaEAGLAGL 82
Cdd:COG0770    1 ILLTLAEIAEAT-GGRLIGDPDLVVTGVSTDSRKIKPGDLFVALKGERFDGHDFVAQALAKGAAAALVSRPL-PADLPLI 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318  83 HVADSRAALGTLGANWRARMSLPLIAVTGSNGKTTVTQMIASILRAWvgDAAFATEGNFNNDIGVPLTLLRLRQDpdtwH 162
Cdd:COG0770   79 VVDDTLKALQQLAAAHRARFNIPVIAITGSNGKTTTKEMLAAVLSTK--GKVLATPGNFNNEIGVPLTLLRLPED----H 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318 163 RAAVVELGMNHVGEIAQLARMATPTVALVNNAQREHQEFMASVEAVARENGAVIEALGANGTAVFPSDDAHAAVWQALAG 242
Cdd:COG0770  153 EFAVLEMGMNHPGEIAYLARIARPDIAVITNIGPAHLEGFGSLEGIARAKGEIFEGLPPGGVAVLNADDPLLAALAERAK 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318 243 TRpTLTFSLEGPSDLVAEAV-WSGDHWAAVLHTPAGATAIRLRVAGWHNVKNALAATACALAAGCPLEAVARGLEAFEPV 321
Cdd:COG0770  233 AR-VLTFGLSEDADVRAEDIeLDEDGTRFTLHTPGGELEVTLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPV 311

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 738298318 322 KGRSQVKALQRGgraVTLVDDSYNANPDSVRAAIDVLATLP--GPRWLVLGDMGEVGDQGPAFHAEVGRYAAACGIDA 397
Cdd:COG0770  312 KGRLEVIEGAGG---VTLIDDSYNANPDSMKAALDVLAQLPggGRRIAVLGDMLELGEESEELHREVGELAAELGIDR 386
 
Name Accession Description Interval E-value
MurF COG0770
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 3-397 1.75e-154

UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440533 [Multi-domain]  Cd Length: 451  Bit Score: 443.39  E-value: 1.75e-154
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318   3 VMMDLRLAHALLpGSTLVGDPATPLLRVHSDTRTLRAGDLFVALKGERFDAHDFLPQARAAGAVAAIAEHGLaEAGLAGL 82
Cdd:COG0770    1 ILLTLAEIAEAT-GGRLIGDPDLVVTGVSTDSRKIKPGDLFVALKGERFDGHDFVAQALAKGAAAALVSRPL-PADLPLI 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318  83 HVADSRAALGTLGANWRARMSLPLIAVTGSNGKTTVTQMIASILRAWvgDAAFATEGNFNNDIGVPLTLLRLRQDpdtwH 162
Cdd:COG0770   79 VVDDTLKALQQLAAAHRARFNIPVIAITGSNGKTTTKEMLAAVLSTK--GKVLATPGNFNNEIGVPLTLLRLPED----H 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318 163 RAAVVELGMNHVGEIAQLARMATPTVALVNNAQREHQEFMASVEAVARENGAVIEALGANGTAVFPSDDAHAAVWQALAG 242
Cdd:COG0770  153 EFAVLEMGMNHPGEIAYLARIARPDIAVITNIGPAHLEGFGSLEGIARAKGEIFEGLPPGGVAVLNADDPLLAALAERAK 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318 243 TRpTLTFSLEGPSDLVAEAV-WSGDHWAAVLHTPAGATAIRLRVAGWHNVKNALAATACALAAGCPLEAVARGLEAFEPV 321
Cdd:COG0770  233 AR-VLTFGLSEDADVRAEDIeLDEDGTRFTLHTPGGELEVTLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPV 311

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 738298318 322 KGRSQVKALQRGgraVTLVDDSYNANPDSVRAAIDVLATLP--GPRWLVLGDMGEVGDQGPAFHAEVGRYAAACGIDA 397
Cdd:COG0770  312 KGRLEVIEGAGG---VTLIDDSYNANPDSMKAALDVLAQLPggGRRIAVLGDMLELGEESEELHREVGELAAELGIDR 386
PRK11929 PRK11929
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ...
 29-397 7.99e-138

bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;


Pssm-ID: 237025 [Multi-domain]  Cd Length: 958  Bit Score: 417.18  E-value: 7.99e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318  29 RVHSDTRTLRAGDLFVALKGERFDAHDFLPQARAAGAVAAIAEHGLAEAGLAGLHVADSRAALGTLGANWRARMSLPLIA 108
Cdd:PRK11929 528 AVSTDSRSVGRGELFVALRGENFDGHDYLPQAFAAGACAAVVERQVADVDLPQIVVDDTRAALGRLATAWRARFSLPVVA 607

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318 109 VTGSNGKTTVTQMIASILRAWVGDAA-FATEGNFNNDIGVPLTLLRLRQDpdtwHRAAVVELGMNHVGEIAQLARMATPT 187
Cdd:PRK11929 608 ITGSNGKTTTKEMIAAILAAWQGEDRvLATEGNFNNEIGVPLTLLRLRAQ----HRAAVFELGMNHPGEIAYLAAIAAPT 683

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318 188 VALVNNAQREHQEFMASVEAVARENGAVIEALGANGTAVFPSDDAHAAVWQALAGTRPTLTFSLEGPSDLVAEAVWSGDH 267
Cdd:PRK11929 684 VALVTNAQREHQEFMHSVEAVARAKGEIIAALPEDGVAVVNGDDPYTAIWAKLAGARRVLRFGLQPGADVYAEKIAKDIS 763

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318 268 WAAV------LHTPAGATAIRLRVAGWHNVKNALAATACALAAGCPLEAVARGLEAFEPVKGRSQVKALQRGgraVTLVD 341
Cdd:PRK11929 764 VGEAggtrcqVVTPAGSAEVYLPLIGEHNLRNALAAIACALAAGASLKQIRAGLERFQPVAGRMQRRRLSCG---TRIID 840

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 738298318 342 DSYNANPDSVRAAIDVLATLP-GPRWLVLGDMGEVGDQGPAFHAEVGRYAAACGIDA 397
Cdd:PRK11929 841 DTYNANPDSMRAAIDVLAELPnGPRALVLGDMLELGDNGPAMHREVGKYARQLGIDA 897
murF TIGR01143
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ...
 33-397 3.16e-123

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273468 [Multi-domain]  Cd Length: 417  Bit Score: 362.74  E-value: 3.16e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318   33 DTRTLRAGDLFVALKGERFDAHDFLPQARAAGAVAAIAEH-GLAEAGLAGLHVADSRAALGTLGANWRARMSLPLIAVTG 111
Cdd:TIGR01143   2 DSRAIKPGDLFIALKGERFDGHDFVEQALAAGAVAVVVDReVGPDNGLPQILVDDTLEALQALARAKRAKFSGKVIGITG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318  112 SNGKTTVTQMIASILRAWVGdaAFATEGNFNNDIGVPLTLLRLRQDpdtwHRAAVVELGMNHVGEIAQLARMATPTVALV 191
Cdd:TIGR01143  82 SSGKTTTKEMLAAILSHKYK--VFATPGNFNNEIGLPLTLLRAPGD----HDYAVLEMGASHPGEIAYLAEIAKPDIAVI 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318  192 NNAQREHQEFMASVEAVARENGAVIEALGANGTAVFPSDDAHAAVWQALAGTRPTLTFSLEGpSDLVAEAVWSGDHWAA- 270
Cdd:TIGR01143 156 TNIGPAHLEGFGSLEGIAEAKGEILQGLKENGIAVINADDPAFADLAKRLPNRNILSFGFEG-GDFVAKDISYSALGSTs 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318  271 -VLHTPAGATAIRLRVAGWHNVKNALAATACALAAGCPLEAVARGLEAFEPVKGRSQVKALQRggraVTLVDDSYNANPD 349
Cdd:TIGR01143 235 fTLVAPGGEFEVSLPLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKLVKGRFEVQTKNG----LTLIDDTYNANPD 310

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 738298318  350 SVRAAIDVLATLPGPRWLVLGDMGEVGDQGPAFHAEVGRYAAACGIDA 397
Cdd:TIGR01143 311 SMRAALDALARFPGKKILVLGDMAELGEYSEELHAEVGRYANSLGIDL 358
Mur_ligase_M pfam08245
Mur ligase middle domain;
109-293 3.90e-38

Mur ligase middle domain;


Pssm-ID: 462409 [Multi-domain]  Cd Length: 199  Bit Score: 136.28  E-value: 3.90e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318  109 VTGSNGKTTVTQMIASILR------AWVGDAAFATEGNFNNDIGVPLTLLRLrqdPDTWHRAAVVELGMNHVGEiAQLAR 182
Cdd:pfam08245   1 VTGTNGKTTTTELIAAILSlaggviGTIGTYIGKSGNTTNNAIGLPLTLAEM---VEAGAEYAVLEVSSHGLGE-GRLSG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318  183 MATPTVALVNNAQREHQEFMASVEAVARENGAVIEALGANGTAVFPSDDAHAAVWQALAGTRP--TLTFSLEGPSDLVA- 259
Cdd:pfam08245  77 LLKPDIAVFTNISPDHLDFHGTMENYAKAKAELFEGLPEDGIAVINADDPYGAFLIAKLKKAGvrVITYGIEGEADLRAa 156

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 738298318  260 --EAVWSGDHwAAVLHTPAGATAIRLRVAGWHNVKN 293
Cdd:pfam08245 157 niELSSDGTS-FDLFTVPGGELEIEIPLLGRHNVYN 191
 
Name Accession Description Interval E-value
MurF COG0770
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 3-397 1.75e-154

UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440533 [Multi-domain]  Cd Length: 451  Bit Score: 443.39  E-value: 1.75e-154
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318   3 VMMDLRLAHALLpGSTLVGDPATPLLRVHSDTRTLRAGDLFVALKGERFDAHDFLPQARAAGAVAAIAEHGLaEAGLAGL 82
Cdd:COG0770    1 ILLTLAEIAEAT-GGRLIGDPDLVVTGVSTDSRKIKPGDLFVALKGERFDGHDFVAQALAKGAAAALVSRPL-PADLPLI 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318  83 HVADSRAALGTLGANWRARMSLPLIAVTGSNGKTTVTQMIASILRAWvgDAAFATEGNFNNDIGVPLTLLRLRQDpdtwH 162
Cdd:COG0770   79 VVDDTLKALQQLAAAHRARFNIPVIAITGSNGKTTTKEMLAAVLSTK--GKVLATPGNFNNEIGVPLTLLRLPED----H 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318 163 RAAVVELGMNHVGEIAQLARMATPTVALVNNAQREHQEFMASVEAVARENGAVIEALGANGTAVFPSDDAHAAVWQALAG 242
Cdd:COG0770  153 EFAVLEMGMNHPGEIAYLARIARPDIAVITNIGPAHLEGFGSLEGIARAKGEIFEGLPPGGVAVLNADDPLLAALAERAK 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318 243 TRpTLTFSLEGPSDLVAEAV-WSGDHWAAVLHTPAGATAIRLRVAGWHNVKNALAATACALAAGCPLEAVARGLEAFEPV 321
Cdd:COG0770  233 AR-VLTFGLSEDADVRAEDIeLDEDGTRFTLHTPGGELEVTLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPV 311

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 738298318 322 KGRSQVKALQRGgraVTLVDDSYNANPDSVRAAIDVLATLP--GPRWLVLGDMGEVGDQGPAFHAEVGRYAAACGIDA 397
Cdd:COG0770  312 KGRLEVIEGAGG---VTLIDDSYNANPDSMKAALDVLAQLPggGRRIAVLGDMLELGEESEELHREVGELAAELGIDR 386
PRK11929 PRK11929
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ...
 29-397 7.99e-138

bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;


Pssm-ID: 237025 [Multi-domain]  Cd Length: 958  Bit Score: 417.18  E-value: 7.99e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318  29 RVHSDTRTLRAGDLFVALKGERFDAHDFLPQARAAGAVAAIAEHGLAEAGLAGLHVADSRAALGTLGANWRARMSLPLIA 108
Cdd:PRK11929 528 AVSTDSRSVGRGELFVALRGENFDGHDYLPQAFAAGACAAVVERQVADVDLPQIVVDDTRAALGRLATAWRARFSLPVVA 607

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318 109 VTGSNGKTTVTQMIASILRAWVGDAA-FATEGNFNNDIGVPLTLLRLRQDpdtwHRAAVVELGMNHVGEIAQLARMATPT 187
Cdd:PRK11929 608 ITGSNGKTTTKEMIAAILAAWQGEDRvLATEGNFNNEIGVPLTLLRLRAQ----HRAAVFELGMNHPGEIAYLAAIAAPT 683

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318 188 VALVNNAQREHQEFMASVEAVARENGAVIEALGANGTAVFPSDDAHAAVWQALAGTRPTLTFSLEGPSDLVAEAVWSGDH 267
Cdd:PRK11929 684 VALVTNAQREHQEFMHSVEAVARAKGEIIAALPEDGVAVVNGDDPYTAIWAKLAGARRVLRFGLQPGADVYAEKIAKDIS 763

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318 268 WAAV------LHTPAGATAIRLRVAGWHNVKNALAATACALAAGCPLEAVARGLEAFEPVKGRSQVKALQRGgraVTLVD 341
Cdd:PRK11929 764 VGEAggtrcqVVTPAGSAEVYLPLIGEHNLRNALAAIACALAAGASLKQIRAGLERFQPVAGRMQRRRLSCG---TRIID 840

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 738298318 342 DSYNANPDSVRAAIDVLATLP-GPRWLVLGDMGEVGDQGPAFHAEVGRYAAACGIDA 397
Cdd:PRK11929 841 DTYNANPDSMRAAIDVLAELPnGPRALVLGDMLELGDNGPAMHREVGKYARQLGIDA 897
murF TIGR01143
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ...
 33-397 3.16e-123

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273468 [Multi-domain]  Cd Length: 417  Bit Score: 362.74  E-value: 3.16e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318   33 DTRTLRAGDLFVALKGERFDAHDFLPQARAAGAVAAIAEH-GLAEAGLAGLHVADSRAALGTLGANWRARMSLPLIAVTG 111
Cdd:TIGR01143   2 DSRAIKPGDLFIALKGERFDGHDFVEQALAAGAVAVVVDReVGPDNGLPQILVDDTLEALQALARAKRAKFSGKVIGITG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318  112 SNGKTTVTQMIASILRAWVGdaAFATEGNFNNDIGVPLTLLRLRQDpdtwHRAAVVELGMNHVGEIAQLARMATPTVALV 191
Cdd:TIGR01143  82 SSGKTTTKEMLAAILSHKYK--VFATPGNFNNEIGLPLTLLRAPGD----HDYAVLEMGASHPGEIAYLAEIAKPDIAVI 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318  192 NNAQREHQEFMASVEAVARENGAVIEALGANGTAVFPSDDAHAAVWQALAGTRPTLTFSLEGpSDLVAEAVWSGDHWAA- 270
Cdd:TIGR01143 156 TNIGPAHLEGFGSLEGIAEAKGEILQGLKENGIAVINADDPAFADLAKRLPNRNILSFGFEG-GDFVAKDISYSALGSTs 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318  271 -VLHTPAGATAIRLRVAGWHNVKNALAATACALAAGCPLEAVARGLEAFEPVKGRSQVKALQRggraVTLVDDSYNANPD 349
Cdd:TIGR01143 235 fTLVAPGGEFEVSLPLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKLVKGRFEVQTKNG----LTLIDDTYNANPD 310

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 738298318  350 SVRAAIDVLATLPGPRWLVLGDMGEVGDQGPAFHAEVGRYAAACGIDA 397
Cdd:TIGR01143 311 SMRAALDALARFPGKKILVLGDMAELGEYSEELHAEVGRYANSLGIDL 358
murF PRK10773
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed
 12-396 7.23e-91

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed


Pssm-ID: 182718 [Multi-domain]  Cd Length: 453  Bit Score: 281.15  E-value: 7.23e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318  12 ALLPGSTLVGDPATpLLRVHSDTRTLRAGDLFVALKGERFDAHDFLPQARAAGAVAAIAEHGLAeAGLAGLHVADSRAAL 91
Cdd:PRK10773  10 ADILNGELQGADIT-IDAVTTDTRKVTPGCLFVALKGERFDAHDFADDAKAAGAGALLVSRPLD-IDLPQLVVKDTRLAF 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318  92 GTLGANWRARMSLPLIAVTGSNGKTTVTQMIASILRAwVGDAaFATEGNFNNDIGVPLTLLRLRQDpdtwHRAAVVELGM 171
Cdd:PRK10773  88 GQLAAWVRQQVPARVVALTGSSGKTSVKEMTAAILRQ-CGNT-LYTAGNLNNDIGVPLTLLRLTPE----HDYAVIELGA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318 172 NHVGEIAQLARMATPTVALVNNAQREHQEFMASVEAVARENGAVIEALGANGTAVFPSDDAHAAVWQALAGTRPTLTFSL 251
Cdd:PRK10773 162 NHQGEIAYTVSLTRPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNADSNDWLNWQSVIGSKTVWRFSP 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318 252 EGPS--DLVAEAVWSGDHWAA-VLHTPAGATAIRLRVAGWHNVKNALAATACALAAGCPLEAVARGLEAFEPVKGRSQVK 328
Cdd:PRK10773 242 NAANsvDFTATNIHVTSHGTEfTLHTPTGSVDVLLPLPGRHNIANALAAAALAMSVGATLDAVKAGLANLKAVPGRLFPI 321

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 738298318 329 ALQRGGravTLVDDSYNANPDSVRAAIDVLATLPGPRWLVLGDMGEVGDQGPAFHAEVGRYAAACGID 396
Cdd:PRK10773 322 QLAEGQ---LLLDDSYNANVGSMTAAAQVLAEMPGYRVMVVGDMAELGAESEACHRQVGEAAKAAGID 386
PRK14093 PRK14093
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; ...
 16-396 4.78e-50

UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional


Pssm-ID: 184501 [Multi-domain]  Cd Length: 479  Bit Score: 175.35  E-value: 4.78e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318  16 GSTLVGDPATPLLRVHSDTRTLRAGDLFVALKGERFDAHDFLPQARAAGAVAAIAEHGLAE---AGLAGLHVADSRAALG 92
Cdd:PRK14093  17 GATRSGALPRDVTGISIDSRTLAPGDAYFAIKGDVHDGHAFVAAALKAGAALAVVERAQRDkfaADAPLLVVDDVLAALR 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318  93 TLGANWRARMSLPLIAVTGSNGKTTVTQMIASILRAwvGDAAFATEGNFNNDIGVPLTLLRLRQDPdtwhRAAVVELGMN 172
Cdd:PRK14093  97 DLGRAARARLEAKVIAVTGSVGKTSTKEALRGVLGA--QGETHASVASFNNHWGVPLSLARCPADA----RFAVFEIGMN 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318 173 HVGEIAQLARMATPTVALVNNAQREHQEFMASVEAVARENGAVIEALGANGTAVFPSDDAHAAVWQALA---GTRPTLTF 249
Cdd:PRK14093 171 HAGEIEPLVKMVRPHVAIITTVEPVHLEFFSGIEAIADAKAEIFTGLEPGGAAVLNRDNPQFDRLAASAraaGIARIVSF 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318 250 SLEGPS-----DLVAEAVWSGDHwAAVLHTPagaTAIRLRVAGWHNVKNALAATACALAAGCPLEAVARGLEAFEPVKGR 324
Cdd:PRK14093 251 GADEKAdarllDVALHADCSAVH-ADILGHD---VTYKLGMPGRHIAMNSLAVLAAAELAGADLALAALALSQVQPAAGR 326

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 738298318 325 SQVKALQRGGRAVTLVDDSYNANPDSVRAAIDVLATLP----GPRWLVLGDMGEVGDQGPAFHAEVGRYAAACGID 396
Cdd:PRK14093 327 GVRHTLEVGGGEATLIDESYNANPASMAAALGVLGRAPvgpqGRRIAVLGDMLELGPRGPELHRGLAEAIRANAID 402
MurE COG0769
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 30-375 7.54e-39

UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440532 [Multi-domain]  Cd Length: 459  Bit Score: 144.84  E-value: 7.54e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318  30 VHSDTRTLRAGDLFVALKGERFDAHDFLPQaraagavaaIAEHG-----------LAEAGLAGLHVADSRAALGTLGANW 98
Cdd:COG0769    2 ITYDSRKVKPGDLFVALPGARVDGHDFIAQ---------AIARGavavvteapgaLLAAGVPVIVVPDPRAALALLAAAF 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318  99 RARMS--LPLIAVTGSNGKTTVTQMIASILRAwVGDAA--FATEGNFNNDIGVP--LTLLrlrqDPDTWHR--AAVVELG 170
Cdd:COG0769   73 YGHPSqkLKLIGVTGTNGKTTTTYLLAQILRA-LGKKTglIGTVGNGIGGELIPssLTTP----EALDLQRllAEMVDAG 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318 171 MNHV-------GeIAQlARMA--TPTVALVNNAQREHQEFMASVEAVARENGAVIEALGANGTAVFPSDDAHAAVWQALA 241
Cdd:COG0769  148 VTHVvmevsshA-LDQ-GRVDgvRFDVAVFTNLTRDHLDYHGTMEAYFAAKARLFDQLGPGGAAVINADDPYGRRLAAAA 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318 242 GTRpTLTFSLEGPSDLVAEAV-WSGDHWAAVLHTPAGATAIRLRVAGWHNVKNALAATACALAAGCPLEAVARGLEAFEP 320
Cdd:COG0769  226 PAR-VITYGLKADADLRATDIeLSADGTRFTLVTPGGEVEVRLPLIGRFNVYNALAAIAAALALGIDLEEILAALEKLKG 304

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 738298318 321 VKGRSQVkaLQRGGRAVTLVDdsYNANPDSVRAAIDVLATLPGPR-WLVLG-----------DMGEV 375
Cdd:COG0769  305 VPGRMER--VDGGQGPTVIVD--YAHTPDALENVLEALRPHTKGRlIVVFGcggdrdrgkrpLMGEI 367
Mur_ligase_M pfam08245
Mur ligase middle domain;
109-293 3.90e-38

Mur ligase middle domain;


Pssm-ID: 462409 [Multi-domain]  Cd Length: 199  Bit Score: 136.28  E-value: 3.90e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318  109 VTGSNGKTTVTQMIASILR------AWVGDAAFATEGNFNNDIGVPLTLLRLrqdPDTWHRAAVVELGMNHVGEiAQLAR 182
Cdd:pfam08245   1 VTGTNGKTTTTELIAAILSlaggviGTIGTYIGKSGNTTNNAIGLPLTLAEM---VEAGAEYAVLEVSSHGLGE-GRLSG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318  183 MATPTVALVNNAQREHQEFMASVEAVARENGAVIEALGANGTAVFPSDDAHAAVWQALAGTRP--TLTFSLEGPSDLVA- 259
Cdd:pfam08245  77 LLKPDIAVFTNISPDHLDFHGTMENYAKAKAELFEGLPEDGIAVINADDPYGAFLIAKLKKAGvrVITYGIEGEADLRAa 156

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 738298318  260 --EAVWSGDHwAAVLHTPAGATAIRLRVAGWHNVKN 293
Cdd:pfam08245 157 niELSSDGTS-FDLFTVPGGELEIEIPLLGRHNVYN 191
PRK11929 PRK11929
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ...
 2-392 1.46e-32

bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;


Pssm-ID: 237025 [Multi-domain]  Cd Length: 958  Bit Score: 129.82  E-value: 1.46e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318   2 SVMMDLRLAHALLPGSTLVGDPAtPLLRVHSDTRTLRAGDLFVALKGERFDAHDFLPQARAAGAVAAIAEHGLAEAGLAG 81
Cdd:PRK11929   5 NRLGNVKLEELLQALAWLRGCVA-ATADLRLDSREVQPGDLFVACRGAASDGRAFIDQALARGAAAVLVEAEGEDQVAAA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318  82 ----LHVADSRAALGTLGANWRARMS--LPLIAVTGSNGKTTVTQMIASILRAwvGDAAFATEGNFNN-----DIGVPLT 150
Cdd:PRK11929  84 dalvLPVADLRKALGELAARWYGRPSeqLSLVAVTGTNGKTSCAQLLAQLLTR--LGKPCGSIGTLGArldgrLIPGSLT 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318 151 LLrlrqDPDTWHR--AAVVELGMNHVGEIA-----QLARMATPT--VALVNNAQREHQEFMASVEAVARENGAVIEALGA 221
Cdd:PRK11929 162 TP----DAIILHRilARMRAAGADAVAMEAsshglEQGRLDGLRiaVAGFTNLTRDHLDYHGTMQDYEEAKAALFSKLPG 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318 222 NGTAVFPSDDAHAA-VWQALAGTRPTLTFSLEGPSDLVAEAVWSGDH-WAAVLHTPAGATAIRLRVAGWHNVKNALAATA 299
Cdd:PRK11929 238 LGAAVINADDPAAArLLAALPRGLKVGYSPQNAGADVQARDLRATAHgQVFTLATPDGSYQLVTRLLGRFNVSNLLLVAA 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318 300 CALAAGCPLEAVARGLEAFEPVKGRSQ-VKALQRGGRAVTLVDdsYNANPDSVRAAIDVLATLPGPR----WLVLGdMGe 374
Cdd:PRK11929 318 ALKKLGLPLAQIARALAAVSPVPGRMErVGPTAGAQGPLVVVD--YAHTPDALAKALTALRPVAQARngrlVCVFG-CG- 393

                        410
                 ....*....|....*...
gi 738298318 375 vGDQGPAFHAEVGRYAAA 392
Cdd:PRK11929 394 -GDRDKGKRPEMGRIAAE 410
PRK11930 PRK11930
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine ...
 33-396 8.60e-28

putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional


Pssm-ID: 237026 [Multi-domain]  Cd Length: 822  Bit Score: 115.44  E-value: 8.60e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318  33 DTRTLRAGD--LFVALKGERFDAHDFLPQARAAGAVAAIAEHGLAEAGLAG----LHVADSRAALGTLGANWRARMSLPL 106
Cdd:PRK11930  30 DSRSLSFPEntLFFALKGERNDGHRYIQELYEKGVRNFVVSEEKHPEESYPdanfLKVKDPLKALQELAAYHRSQFDIPV 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318 107 IAVTGSNGKTTVTQMIASILRAwvGDAAFATEGNFNNDIGVPLTLLRLRQDpdtwHRAAVVELGMNHVGEIAQLARMATP 186
Cdd:PRK11930 110 IGITGSNGKTIVKEWLYQLLSP--DYNIVRSPRSYNSQIGVPLSVWQLNEE----HELGIFEAGISQPGEMEALQKIIKP 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318 187 TVALVNNAQREHQEFMASVEAVARENGAVI---EALGANGtavfPSDDAHAAVWQALaGTRPTLTFSLEGPSDlvaeavw 263
Cdd:PRK11930 184 TIGILTNIGGAHQENFRSIKQKIMEKLKLFkdcDVIIYNG----DNELISSCITKSN-LTLKLISWSRKDPEA------- 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318 264 sgDHWAAVLHTPAGATAIRLRVAGWHN-----------VKNALAATACALAAGCPLEAVARGLEAFEPVKGRSQVKALQR 332
Cdd:PRK11930 252 --PLYIPFVEKKEDHTVISYTYKGEDFhfeipfiddasIENLIHCIAVLLYLGYSADQIQERMARLEPVAMRLEVKEGIN 329

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 738298318 333 GgraVTLVDDSYNANPDSVRAAIDVL--ATLPGPRWLVLGDMGEVGDQGPAFHAEVGRYAAACGID 396
Cdd:PRK11930 330 N---CTLINDSYNSDLQSLDIALDFLnrRSQSKKKTLILSDILQSGQSPEELYRKVAQLISKRGID 392
murE PRK00139
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
 30-370 1.89e-25

UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional


Pssm-ID: 234660 [Multi-domain]  Cd Length: 460  Bit Score: 107.14  E-value: 1.89e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318  30 VHSDTRTLRAGDLFVALKGERFDAHDFLPQARAAGAVAAIAEH-GLAEAGLAGLHVADSRAALGTLGANW--RARMSLPL 106
Cdd:PRK00139  18 LTYDSRKVKPGDLFVALPGHKVDGRDFIAQAIANGAAAVVAEAdGEAGTGVPVIIVPDLRKALALLAAAFygHPSDKLKL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318 107 IAVTGSNGKTTVTQMIASILRAWVGDAA-FATEGNFNNDIGVP--LTLLrlrqDPDTWHR--AAVVELGMNHV------- 174
Cdd:PRK00139  98 IGVTGTNGKTTTAYLLAQILRLLGEKTAlIGTLGNGIGGELIPsgLTTP----DALDLQRllAELVDAGVTYAamevssh 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318 175 GeIAQlARMA--TPTVALVNNAQREHQEFMASVEAVARENGAVIEALGanGTAVFPSDDAHAAVWQALAGTRpTLTFSle 252
Cdd:PRK00139 174 A-LDQ-GRVDglKFDVAVFTNLSRDHLDYHGTMEDYLAAKARLFSELG--LAAVINADDEVGRRLLALPDAY-AVSMA-- 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318 253 gPSDLVAEavwsgdhwaAVLHTPAGATA-----IRLRVAGWHNVKNALAATACALAAGCPLEAVARGLEAFEPVKGRSQV 327
Cdd:PRK00139 247 -GADLRAT---------DVEYTDSGQTFtlvteVESPLIGRFNVSNLLAALAALLALGVPLEDALAALAKLQGVPGRMER 316

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 738298318 328 kaLQRGGRAVTLVDdsYNANPDSVRAAIDVLATLPGPR-WLVLG 370
Cdd:PRK00139 317 --VDAGQGPLVIVD--YAHTPDALEKVLEALRPHAKGRlICVFG 356
murE TIGR01085
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ...
 30-378 2.87e-22

UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273435 [Multi-domain]  Cd Length: 464  Bit Score: 98.16  E-value: 2.87e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318   30 VHSDTRTLRAGDLFVALKGERFDAHDFLPQARAAGAVAAIAEhGLAEAGLAG---LHVADSRAALGTLGANWRARMS--L 104
Cdd:TIGR01085   7 LTLDSREVKPGDLFVAIKGTHVDGHDFIHDAIANGAVAVVVE-RDVDFYVAPvpvIIVPDLRHALSSLAAAFYGHPSkkL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318  105 PLIAVTGSNGKTTVTQMIASILRAWVGDAAF-ATEGNF---NNDIGVPLTLlrlrQDPD--TWHR--AAVVELGmnhvge 176
Cdd:TIGR01085  86 KVIGVTGTNGKTTTTSLIAQLLRLLGKKTGLiGTIGYRlggNDLIKNPAAL----TTPEalTLQStlAEMVEAG------ 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318  177 iAQLARMATPTVALV--------------NNAQREHQEFMASVEAVARENGAVIEALGANGTAVFPSDDAHAAVWqaLAG 242
Cdd:TIGR01085 156 -AQYAVMEVSSHALAqgrvrgvrfdaavfTNLSRDHLDFHGTMENYFAAKASLFTELGLKRFAVINLDDEYGAQF--VKR 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318  243 TRPTLTFSLEG-PSDLVAEAVW---SGDHW---AAVLHTPAGATAIRLRVAGWHNVKNALAATACALAAGC-PLEAVARG 314
Cdd:TIGR01085 233 LPKDITVSAITqPADGRAQDIKitdSGYSFegqQFTFETPAGEGHLHTPLIGRFNVYNLLAALATLLHLGGiDLEDIVAA 312

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 738298318  315 LEAFEPVKGRSQVkaLQRGGRAVTLVDdsYNANPDSVRAAIDVLATLPGPRWLVL----GD--------MGEVGDQ 378
Cdd:TIGR01085 313 LEKFRGVPGRMEL--VDGGQKFLVIVD--YAHTPDALEKALRTLRKHKDGRLIVVfgcgGDrdrgkrplMGAIAEQ 384
MurD COG0771
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ...
 105-370 1.26e-21

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440534 [Multi-domain]  Cd Length: 445  Bit Score: 95.92  E-value: 1.26e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318 105 PLIAVTGSNGKTTVTQMIASILRAWVGDAAFAteGNfnndIGVP-LTLLRLRQDPDTWhraaVVELgmnhvgeiaQLARM 183
Cdd:COG0771  106 PIIAITGTNGKTTTTTLIGHILKAAGLRVAVG--GN----IGTPlLDLLLEPEPPDVY----VLELss------fQLETT 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318 184 AT--PTVALVNNAQREHQEFMASVEAVARENGAVIEALGANGTAVFPSDDAHAAVWQALAGTRpTLTFSLEGPsdlVAEA 261
Cdd:COG0771  170 PSlrPDVAVILNITPDHLDRHGSMEAYAAAKARIFANQTPDDYAVLNADDPLTRALAEEAKAR-VVPFSLKEP---LEGG 245

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318 262 VWSGDHWaavLHTPAGATAI----RLRVAGWHNVKNALAATACALAAGCPLEAVARGLEAFEPVKGRSQVKAlQRGGraV 337
Cdd:COG0771  246 AGLEDGK---LVDRASGEELlpvdDLRLPGRHNLENALAALAAARALGVPPEAIREALRSFKGLPHRLEFVA-EING--V 319

                        250       260       270
                 ....*....|....*....|....*....|...
gi 738298318 338 TLVDDSYNANPDSVRAAidvLATLPGPRWLVLG 370
Cdd:COG0771  320 RFINDSKATNPDATLAA---LESFDGPVVLIAG 349
murD TIGR01087
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ...
 102-397 1.76e-18

UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273436 [Multi-domain]  Cd Length: 433  Bit Score: 86.63  E-value: 1.76e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318  102 MSLPLIAVTGSNGKTTVTQMIASILRAwVGDAAFATeGNfnndIGVPLtLLRLRQDPDTWhraAVVELGMnhvgeiAQLA 181
Cdd:TIGR01087 100 VPLPVVAITGTNGKTTTTSLLYHLLKA-AGLKAFLG-GN----IGTPA-LEVLDQEGAEL---YVLELSS------FQLE 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318  182 RM--ATPTVALVNNAQREHQEFMASVEAVARENGAVIEALGANGTAVFPSDDAHAAVWQALAGTRpTLTFSLEGPSDlva 259
Cdd:TIGR01087 164 TTesLRPEIALILNISEDHLDWHGSFEDYVAAKLKIFARQTEGDVAVLNADDPRFARLAQKSKAQ-VIWFSVEKDAE--- 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318  260 eaVWSGDHWAAVLHTPAGATAirlRVAGWHNVKNALAATACALAAGCPLEAVARGLEAFEPVKGRSQVKAlQRGGraVTL 339
Cdd:TIGR01087 240 --RGLCIRDGGLYLKPNDLEG---SLLGLHNAENILAAIALAKSLGLNLEAILEALRSFKGLPHRLEYVG-QKNG--VHF 311

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318  340 VDDSYNANPDSVRAAidvLATLPGPRWLVLGDMGEVGDQGPAFHAEVGRYAAAC--GIDA 397
Cdd:TIGR01087 312 YNDSKATNVHATLAA---LSAFDNPVILIVGGDDKGADFSPLAPAAAGKVKAVLaiGEDA 368
MurC COG0773
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ...
 107-342 7.30e-16

UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440536 [Multi-domain]  Cd Length: 451  Bit Score: 78.95  E-value: 7.30e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318 107 IAVTGSNGKTTVTQMIASILRAWVGDAAFATEGNFNNdIGVPLtllRLRQDPdtwhrAAVVElgmnhvgeiaqlarmA-- 184
Cdd:COG0773  107 IAVAGTHGKTTTTSMLAHILEEAGLDPTFLIGGILNN-FGTNA---RLGDGD-----YFVAE---------------Ade 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318 185 --------TPTVALVNNAQREHQEFMASVEAVARENGAVIEALGANGTAVFPSDDAHAAVWQALAGtRPTLTFSLEGPSD 256
Cdd:COG0773  163 sdgsflhySPDIAVVTNIEADHLDIYGDLEAIKEAFHEFARNVPFYGLLVLCADDPGLRELLPRCG-RPVITYGFSEDAD 241

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318 257 LVAEAV-WSGDHWAAVLHTPAGATA-IRLRVAGWHNVKNALAATACALAAGCPLEAVARGLEAFEPVKGRSQVKALQRGg 334
Cdd:COG0773  242 YRAENIrIDGGGSTFDVLRRGEELGeVELNLPGRHNVLNALAAIAVALELGVDPEAIAEALASFKGVKRRFELKGEVGG- 320


                 ....*...
gi 738298318 335 raVTLVDD 342
Cdd:COG0773  321 --VTVIDD 326
murC TIGR01082
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial ...
 87-355 3.91e-11

UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial peptidoglycan (murein) biosynthesis. In a few species (Mycobacterium leprae, the Chlamydia), the amino acid may be L-serine or glycine instead of L-alanine. A related protein, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (murein tripeptide ligase) is described by model TIGR01081. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273433 [Multi-domain]  Cd Length: 448  Bit Score: 64.25  E-value: 3.91e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318   87 SRAALgtLGANWRARMSlplIAVTGSNGKTTVTQMIASILRAWVGDAAFATEGNFNNdigvpltllrlrqdpdtWHRAAV 166
Cdd:TIGR01082  87 RRAEM--LAELMRFRHS---IAVAGTHGKTTTTAMIAVILKEAGLDPTVVVGGLVKE-----------------AGTNAR 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318  167 VELGMNHVGEIAQLAR---MATPTVALVNNAQREHQE-FMASVEAVARENGAVIEALGANGTAVFPSDDAHAAVWQALAG 242
Cdd:TIGR01082 145 LGSGEYLVAEADESDAsflHLQPNVAIVTNIEPDHLDtYGSSFERLKAAFEKFIHNLPFYGLAVICADDPVLRELVPKAT 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318  243 TRPTLTFSLEGPSDLVAE--AVWSGDHWAAVLHTPAGATAIRLRVAGWHNVKNALAATACALAAGCPLEAVARGLEAFEP 320
Cdd:TIGR01082 225 EQVITYGGSGEDADYRAEniQQSGAEGKFSVRGKGKLYLEFTLNLPGRHNVLNALAAIAVALELGIDFEAILRALANFQG 304

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 738298318  321 VKGRSQVKAlQRGGraVTLVDDsYNANPDSVRAAI 355
Cdd:TIGR01082 305 VKRRFEILG-EFGG--VLLIDD-YAHHPTEIKATL 335
Mur_ligase_C pfam02875
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ...
 321-396 2.00e-10

Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.


Pssm-ID: 460731 [Multi-domain]  Cd Length: 87  Bit Score: 56.97  E-value: 2.00e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 738298318  321 VKGRSQVKALQRGgraVTLVDDsYNANPDSVRAAIDVLATL-PGPRWLVLGDMgevGDQGPAFHAEVGRYAAACGID 396
Cdd:pfam02875   1 VPGRLEVVGENNG---VLVIDD-YAHNPDAMEAALRALRNLfPGRLILVFGGM---GDRDAEFHALLGRLAAALADV 70
murD PRK14106
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
 105-384 6.25e-09

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional


Pssm-ID: 184511 [Multi-domain]  Cd Length: 450  Bit Score: 57.29  E-value: 6.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318 105 PLIAVTGSNGKTTVTQMIASILRawvgDAAFAT--EGNfnndIGVPLTllrlrqdpdtwhrAAVVELGMNH--VGEIA-- 178
Cdd:PRK14106 109 PIVAITGTNGKTTTTTLLGEIFK----NAGRKTlvAGN----IGYPLI-------------DAVEEYGEDDiiVAEVSsf 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318 179 QLARMAT--PTVALVNNAQREHQEFMASVEAVARENGAVIEALGANGTAVFPSDDAHAAvwqALAGTRP--TLTFSlegP 254
Cdd:PRK14106 168 QLETIKEfkPKVGCILNITPDHLDRHKTMENYIKAKARIFENQRPSDYTVLNYDDPRTR---SLAKKAKarVIFFS---R 241

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318 255 SDLVAEAVW-SGDHwaAVLHTPAGATAI----RLRVAGWHNVKNALAATACALAAGCPLEAVARGLEAFEPVKGRSQVKA 329
Cdd:PRK14106 242 KSLLEEGVFvKNGK--IVISLGGKEEEVididEIFIPGEHNLENALAATAAAYLLGISPDVIANTLKTFKGVEHRIEFVA 319

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 738298318 330 LQRGgraVTLVDDSYNANPDsvrAAIDVLATLPGPRWLVLGdmGEvgDQGPAFHA 384
Cdd:PRK14106 320 EING---VKFINDSKGTNPD---AAIKALEAYETPIVLIAG--GY--DKGSDFDE 364
PRK14022 PRK14022
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;
33-376 7.35e-08

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;


Pssm-ID: 237588 [Multi-domain]  Cd Length: 481  Bit Score: 54.27  E-value: 7.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318  33 DTRTLRAGDLFVAlKGERFdAHDFLPQARAAGAVAAIAEHGLaEAGLAGLHVADSRAALGTLGANWRARMS--LPLIAVT 110
Cdd:PRK14022  40 DSRTADEGTLFFA-KGAYF-KHKFLQNAITQGLKLYVSEKDY-EVGIPQVIVPDIKKAMSLIAMEFYDNPQhkLKLLAFT 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318 111 GSNGKTTVTQMIASILRAWVGDAAFAT-------EGNFNNDIGVP--LTLLRlrqdpdtwHRAAVVELGMNH-VGEIAQL 180
Cdd:PRK14022 117 GTKGKTTAAYFAYHILKQLHKPAMLSTmnttldgETFFKSALTTPesLDLFK--------MMAEAVDNGMTHlIMEVSSQ 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318 181 A------RMATPTVALVNNAQREHQEFMA--SVEAVARENGAVIEALGAngtAVFPSDDAHAAVWQALAGTRPTLTFSLE 252
Cdd:PRK14022 189 AylvgrvYGLTFDVGVFLNITPDHIGPIEhpTFEDYFYHKRLLMENSKA---VVVNSDMDHFSELLEQVTPQEHDFYGID 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738298318 253 GPSDLVAEAVWSGDhwaaVLHTPAGATAIRLrvAGWHNVKNALAATACALAAGCPLEAVARGLEAfEPVKGRSQVkaLQR 332
Cdd:PRK14022 266 SENQIMASNAFSFE----ATGKLAGTYDIQL--IGKFNQENAMAAGLACLRLGASLEDIQKGIAQ-TPVPGRMEV--LTQ 336

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 738298318 333 GGRAVTLVDdsYNANPDSVRAAIDVLATLP-GPRWLVLGDMGEVG 376
Cdd:PRK14022 337 SNGAKVFID--YAHNGDSLNKLIDVVEEHQkGKLILLLGAAGNKG 379
PRK14016 PRK14016
cyanophycin synthetase; Provisional
 105-127 2.51e-05

cyanophycin synthetase; Provisional


Pssm-ID: 237586 [Multi-domain]  Cd Length: 727  Bit Score: 46.30  E-value: 2.51e-05
                         10        20
                 ....*....|....*....|...
gi 738298318 105 PLIAVTGSNGKTTVTQMIASILR 127
Cdd:PRK14016 481 PIVAVTGTNGKTTTTRLIAHILK 503
Mur_ligase pfam01225
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes ...
 33-99 8.62e-04

Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.


Pssm-ID: 460121 [Multi-domain]  Cd Length: 84  Bit Score: 37.98  E-value: 8.62e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 738298318   33 DTRTLRAGDLFVALKGERFDAHDF------------LPQARAAGAVAAIAEhgLAEAGLAGLHVADSRAALGTLGANWR 99
Cdd:pfam01225   8 DGRGMSPGALFLALKGYRVDGSDFieslialgaaavVGHDAANNISPDNPE--LEAAKVPGIPVIDRREALAELAAAFY 84
FolC COG0285
Folylpolyglutamate synthase/Dihydropteroate synthase [Coenzyme transport and metabolism]; ...
 103-128 5.65e-03

Folylpolyglutamate synthase/Dihydropteroate synthase [Coenzyme transport and metabolism]; Folylpolyglutamate synthase/Dihydropteroate synthase is part of the Pathway/BioSystem: Folate biosynthesis


Pssm-ID: 440054 [Multi-domain]  Cd Length: 423  Bit Score: 38.55  E-value: 5.65e-03
                         10        20
                 ....*....|....*....|....*.
gi 738298318 103 SLPLIAVTGSNGKTTVTQMIASILRA 128
Cdd:COG0285   39 KLPVIHVAGTNGKGSTAAMLESILRA 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH