|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
8-393 |
7.68e-168 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 475.20 E-value: 7.68e-168
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 8 LLFILLTALIDVMGIGLIIPVLPGLVKELAGSEAGGARFIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVL 87
Cdd:cd17388 1 LIFILVTVLLDAMGIGLIMPVLPTLLREFVGDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 88 DYLLLFFSPNLWWLLVGRLIAGVTGASLTVANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLGEHGLRAPFLF 167
Cdd:cd17388 81 DYLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISPRAPFLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 168 AAGLTALNFLYGLLVLPESLPPEKRGAAGGGTLNPFTPLRALTEYPLLRGLTLTFVLLGLAGQVIVSTWVLYTEGVLRWS 247
Cdd:cd17388 161 AAGLNGLNFLLGLFVLPESLPPERRRAFRWRRANPFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFTEDRFDWS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 248 PLQNGIAFAVYGLLTAGVQAGLISPFIARFGERRTIMTGLVASTLEFVVLSVARSAPVLYLSLVVGALGGLAQPAMQGLI 327
Cdd:cd17388 241 PTMVGLSLAVFGLLHALFQAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALGGIAGPALQGLL 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 736322654 328 SRQVGEQEQGRVMGAITSLNSLVGVFGPLLATSVFAAGqGAGFPGAAFVLGAVLSILGTVLILSVL 393
Cdd:cd17388 321 SRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAAS-PATWPGLAWIIGAALYLICLVLAYRFF 385
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
11-388 |
8.90e-71 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 226.31 E-value: 8.90e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 11 ILLTALIDVMGIGLIIPVLPGLVKELAGSEAGGaRFIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVLDYL 90
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFNKLGASG-YYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 91 LLFFSPNLWWLLVGRLIAGVTGASLTVANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLG-EHGLRAPFLFAA 169
Cdd:cd17330 80 LLGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLStPYGYALPFLVAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 170 GLTALNFLYGLLVLpeslppekrgaagggtlnpftplralteyPLLRGLTLTFVLLGLAGQVIVSTWVLYTEGVLRWSPL 249
Cdd:cd17330 160 ALALLNLVLVLFFL-----------------------------PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPS 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 250 QNGIAFAVYGLLTAGVQAGLISPFIARFGERRTIMTGLVASTLEFVVLSVARSAPVLYLSLVVGALG-GLAQPAMQGLIS 328
Cdd:cd17330 211 QIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGtGIVFPALSALLS 290
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 329 RQVGEQEQGRVMGAITSLNSLVGVFGPLLATSVFAagqgAGFPGAAFVLGAVLSILGTVL 388
Cdd:cd17330 291 KSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYS----FLGPGVPFLLAAGLLLIALFL 346
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
11-390 |
7.11e-55 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 185.47 E-value: 7.11e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 11 ILLTALIDVMGIGLIIPVLPGLVKELAGSEAggarFIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVLDYL 90
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVA----QIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 91 LLFFSPNLWWLLVGRLIAGVTGASL-TVANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLGEH-GLRAPFLFA 168
Cdd:cd17325 77 LFAFATSYWQLLLARFLQGLASAAVwPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAlGYRAPFLVC 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 169 AGLTALNFLYGLLVLPESLPPEKRGAAGGGTLnpFTPLRALTEYPLLRGLTLTFVLLGLAGQVIVSTWVLYTEGVLRWSP 248
Cdd:cd17325 157 AALALLALVLALLLLPEPRPPPNKRAVSAARL--RSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 249 LQNGIAFAVYGLLTAGVQaGLISPFIARFGERRTIMTGLVASTLEFVVLSVARSAPVLYLSLVV-GALGGLAQPAMQGLI 327
Cdd:cd17325 235 AQIGLLFGAQGLASALSQ-PPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALlGLGLGLVFPATLALL 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 736322654 328 SRQVGEQEQGRVMGAITSLNSLVGVFGPLLATSVFAagqgAGFPGAAFVLGAVLSILGTVLIL 390
Cdd:cd17325 314 ADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYD----AFGFATPFLAAAALLLLAAVLFL 372
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
11-389 |
3.43e-41 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 149.73 E-value: 3.43e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 11 ILLTALIDVMGIGLIIPVLPGLVKELAGSEAGGAR--------------------------FIGVLTAAYAAMQFIFAPI 64
Cdd:cd17389 4 VFLALLLDLLAFTIILPLFPSLLDYYGQNDDSGLYslqissvdwfrdaigapderrynsvlFGGLIGSLFSLLQFLSSPI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 65 LGTLSDRFGRRPVLLLSLAGMVLDYLLLFFSPNLWWLLVGRLIAGVTGASLTVANAYIADVTAPEDRAKNFGRLGATWGV 144
Cdd:cd17389 84 TGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADVTSPKKRSKGMALIGVAFSL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 145 GFILGPMLGGWL-------GEHGLRAPFLFAAGLTALNFLYGLLVLPESLPPEKRGAAGGGTLNPFtplralteypLLRG 217
Cdd:cd17389 164 GFIIGPMIGAYFasftrslGEVFFSMPALFALVLALADLLFIFFFLPETLPSNLRRLGLVYFLYLF----------LFSG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 218 L--TLTFVllglagqvivstwvlyTEGVLRWSPLQNGIAFAVYGLLTAGVQAGLISPfIARFGERRTIMTGLVASTLEFV 295
Cdd:cd17389 234 LefTLTFL----------------THQRFQYTSMQQGKMFFFIGIIMALVQGGYVRR-IKPGKEKKAVLQGLILLIPAFL 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 296 VLSVARSAPVLYLSLVVGALG-GLAQPAMQGLISRQVGEQEQGRVMGAITSLNSLVGVFGPLLATSVF-AAGqgagfPGA 373
Cdd:cd17389 297 LIGWASSVTVLYAGLFLYSFAaATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALARALGPIVACTVYwLAG-----SEA 371
|
410
....*....|....*.
gi 736322654 374 AFVLGAVLSILGTVLI 389
Cdd:cd17389 372 CYTIGALLFLLPLLLL 387
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
2-351 |
8.60e-41 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 147.81 E-value: 8.60e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 2 PRRPPALLFILLTALIDVMGIGLIIPVLPGLVKELAGSEAggarFIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLS 81
Cdd:COG2814 6 RRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPA----QAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 82 LAGMVLDYLLLFFSPNLWWLLVGRLIAGVTGASL-TVANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLGEH- 159
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALfPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLf 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 160 GLRAPFLFAAGLTALNFLYGLLVLPESLPPEKRGAAGggtlnpftPLRALTEYPLLRGLTLTFVLLGLAGQVIVSTWVLY 239
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRG--------SLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLY 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 240 TEGVLRWSPLQNGIAFAVYGLLTAGVQAgLISPFIARFGERRTIMTGLVASTLEFVVLSVARSAPVLYLSLVV-GALGGL 318
Cdd:COG2814 234 LQEVLGLSASAAGLLLALFGLGGVLGAL-LAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLlGFGFGL 312
|
330 340 350
....*....|....*....|....*....|...
gi 736322654 319 AQPAMQGLISRQVGEQEQGRVMGAITSLNSLVG 351
Cdd:COG2814 313 LFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
11-394 |
1.93e-40 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 146.60 E-value: 1.93e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 11 ILLTALIDVMGIGLIIPVLPGLVKELAGSEAggarFIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVLDYL 90
Cdd:cd17390 1 LYLVGFLDLFGVSMILPLLSTHIRSLGASPT----VIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 91 LLFFSPNLWWLLVGRLIAGVTGASLTVANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLGEH--GLRAPFLFA 168
Cdd:cd17390 77 LLGFSTSLALLFLSRIPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETdgGFYYVALLC 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 169 AGLTALNFLYGLLVLPEslppekrgaagggtlnpftplralteyplLRGLTLTFVLLGLAGQVIVSTWVLYTEGVLRWSP 248
Cdd:cd17390 157 SAIFILNAGLVWFLLSK-----------------------------LWDLLLVRFLMGFSVLLFRSNFSLYLEERFDLSP 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 249 LQNGIAFAVYGLLTAGVQ--AGLISPFIARFGERRTIMTGLVASTLeFVVLSVARSAPVLYLSLVVGAL-GGLAQPAMQG 325
Cdd:cd17390 208 KTIGYLISYSGVLGALSGflVGRILKLYKNNEYLLLLHSFILLALS-LLGLALAPSIWLLVLCLTPLSIsSAVLRTCSTS 286
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 736322654 326 LISRQVGEQEQGRVMGAITSLNSLVGVFGPLLATSVFAAGqgagfPGAAFVLGAVLSILGTVLILSVLR 394
Cdd:cd17390 287 LLLSRGKSKERGTLLGVGQSVTSLARILAPLLSGLLQEFS-----VSGPGLLGAVLALAAILLMLARQR 350
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
24-387 |
1.65e-38 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 142.36 E-value: 1.65e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 24 LIIPVLPGLVKELAGseagGARFIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVLDYLLLFFSPNLWWLLV 103
Cdd:cd17331 18 LQQPVLPYLTKKLGV----DSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 104 GRLIAgVTGASLTVANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLGEH-GLRAPFLFAAGLTALNFLYGLLV 182
Cdd:cd17331 94 SRLPS-VFMHAMQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKfGEQAAALVAAVGSLLSIVLVILL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 183 LPESLPPEKRGAAGGGTLNP----FTPLRALTEYPLLRGLTLTFVLLGLAGQVIVSTWVLYTEGVLRWSPLQNGIAFAVY 258
Cdd:cd17331 173 IPSNTKSKREKEAKESASPPsvfnLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYA 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 259 GLLTAGVQAGLISPFIARFGERRTIMTGLVASTLEFVVLSVARSAPVLYLSLVVGALGG-LAQPAMQGLISRQVGEQEQG 337
Cdd:cd17331 253 GVLGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGsVLYTVITSLLTKAVPPEDTG 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 736322654 338 RVMGAITSLNSLVGVFGPLLATSVFAAGQGAGFPGAAFVLGAVLSILGTV 387
Cdd:cd17331 333 TALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAINGLLTVYLLL 382
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
11-392 |
2.93e-32 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 125.38 E-value: 2.93e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 11 ILLTALIDVMGIGLIIPVLPGLVKELAGSEAggarFIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVLDYL 90
Cdd:cd17474 4 VFFATLLAVLGVSIVDPILPAIAEALGASPA----QVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 91 LLFFSPNLWWLLVGRLIAGVTGASLTV-ANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLGEHGLRAPFLFAA 169
Cdd:cd17474 80 LCGLSDSFALLLAGRALQGIGAAGLGPlALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 170 GLTALNFLYGLLVLPESLPPEKRGAAGGgtlnPFTPLRALTEYPLLRGLTLTFVLLGLAGQVIVSTwVLYTEGVLRWSPL 249
Cdd:cd17474 160 ALIPVAFLAILFLLPEPKEKAKSSSATK----LRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYL-PFLLELLYGISPI 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 250 QNGIAFAVYGLLTA--GVQAGLISPfiARFGERRTIMTGLVASTLEFVVLSVARSAPVLYLSLVV-GALGGLAQPAMQGL 326
Cdd:cd17474 235 IIGLLFAGWSVLLAlgSLFVGRLLK--KRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLfGLGLGLNLPLLTTL 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 736322654 327 ISRQVGEQEQGRVMGAITSLNSLVGVFGPLLatsvFAAGQGAGFPGAAFVLGAVLSILGTVLILSV 392
Cdd:cd17474 313 VTELAPEEERGTASSLYNFVRFLGQAVGPLL----FGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
21-377 |
3.82e-30 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 119.68 E-value: 3.82e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 21 GIGLIIPVLPGLVKELAGSEAGG-ARFIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVLDYLLLFFSPNLW 99
Cdd:cd17391 11 GFSLIAPFLPLYIEQLGVTSGGLvELWSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVW 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 100 WLLVGRLIAGVTGASLTVANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLGEH-GLRAPFLFAAGLTALNFLY 178
Cdd:cd17391 91 QLLILRLLQGVFSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLfGIRNVFFITGGLLFLAFLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 179 GLLVLPESLPPEKRGAAgggtLNPFTPLRALTEYPLLRGLTLTFVLLGLAGQVIVSTWVLYtegVLRWSPLQNGIAFaVY 258
Cdd:cd17391 171 TLFFVKEDFKPVEKKKM----VSTKEVWNSVPNPSLLISLFVTTFIIQLANQSIEPILTLY---IRQLMGDASNLAF-IS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 259 GLLTA--GVQAGLISPFIARFGER----RTIMTGLVASTLEFVVLSVARSAPVL-YLSLVVGALGGLAQPAMQGLISRQV 331
Cdd:cd17391 243 GLVFSatGVSSLLSAPRLGKLGDRighhRILLGALLASALLYIPQAFVQTPWQLgILRFLLGLATGGLLPAINSLLAKIT 322
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 736322654 332 GEQEQGRVMGAITSLNSLVGVFGPLLATSVFAA-GQGAGFPGAAFVL 377
Cdd:cd17391 323 PKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHfGYRAVFVVTALLV 369
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
11-388 |
1.54e-29 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 117.70 E-value: 1.54e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 11 ILLTALIDVMGIGLIIPVLPGLVKELAGSEAGgarfIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVLDYL 90
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAV----AGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 91 LLFFSPNLWWLLVGRLIAGV-TGASLTVANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLGEH-GLRAPFLFA 168
Cdd:cd17489 77 LYLLATSVALLLVLRLIHGIgWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHlGFAVLFIVA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 169 AGLTALNFLYGLLVLPESLPPEKRGAAGGGTLNPFTPLRALTEYPLLRGLTLTFvllglagQVIVSTWVLYTEGVLRWSP 248
Cdd:cd17489 157 AVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAY-------GAISTFLPLYAAERGISNA 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 249 lqnGIAFAVYGLLTAGVQAgLISPFIARFGERRTIMTGLVASTLEFVVLSVARSAPVLYLSLVVGALG-GLAQPAMQGLI 327
Cdd:cd17489 230 ---GLFFTVYAIALLLSRP-FSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGfGLLFPALQALA 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 736322654 328 SRQVGEQEQGRVMGAITSLNSLVGVFGPLLATSVFAAGQgagfPGAAFVLGAVLSILGTVL 388
Cdd:cd17489 306 VDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFG----YRAMFLLAAVVVLLALVL 362
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
8-390 |
4.04e-29 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 116.52 E-value: 4.04e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 8 LLFILLTALIDVMGIGLIIPVLPGLVKELAGseaGGARFIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVL 87
Cdd:cd17473 1 LITLLLASTLTVMAGAAIAPALPAIAQHFVP---NSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 88 DYLLLFFSPNLWWLLVGRLIAGV-TGASLTVANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLGEHGLRAPFL 166
Cdd:cd17473 78 GGVAGLFLDSLYALLASRALLGIgVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRAPFL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 167 FAAGLTALNFLYgLLVLPESLPPEKRGAAGGGTLNPFTPLRALteYPLLRGLTLTFVLLglagQVIVSTWVLYTEGVLRW 246
Cdd:cd17473 158 VYLLALPVLILV-LLFLPEPARKSKSAASPGAATAAALPWKRV--LPIYFLAFLAMLLF----YVIPIQLPFLLQERGGG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 247 SPLQNGIAFAVYGLltAGVQAGLISPFI-ARFGERRTIMTGLVASTLEFVVLSVARSAPVLYLSLVVGALG-GLAQPAMQ 324
Cdd:cd17473 231 SAALIGLALAIASL--AGAIGALLFGRLkRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGfGLLLPTLN 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 736322654 325 GLISRQVGEQEQGRVMGAITSLNSLVGVFGPLLatsVFAAGQGAGFPGAAFVLGAVLSILGTVLIL 390
Cdd:cd17473 309 SWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLV---LGPLVNLTGGLSGAFLILGVLALVLAIVLL 371
|
|
| MFS_MFSD14 |
cd17387 |
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ... |
59-362 |
4.64e-28 |
|
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340945 [Multi-domain] Cd Length: 410 Bit Score: 114.05 E-value: 4.64e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 59 FIFAPILGTLSDRFGRRPVLLLSLAGMVLDYLLLFFSPnlWWLLVGRLIAGVTGASLTVANAYIADVTAPEDRAKNFGRL 138
Cdd:cd17387 50 FLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMRISP--WWYFAMISVSGIFSVTFSVIFAYVADITTEEERSTAYGLV 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 139 GATWGVGFILGPMLGGWLGE-HGLRAPFLFAAGLTALNFLYGLLVLPESLPPEKRGAAGGGTL-----NPFTPLRALTEY 212
Cdd:cd17387 128 SATFAASLVTSPALGAYLSEsYGDNLVVLVATIVALLDICFILLAVPESLPEKMRPASWGAPIsweqaDPFASLRKVGKD 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 213 PLLRGLTLTFVL--LGLAGQviVSTWVLYTEGVLRWSPLQNGIAFAVYGLLTAGVQAGLISPFIARFGERRTIMTGLVAS 290
Cdd:cd17387 208 KTVLLICITVFLsyLPEAGQ--YSSFFVYLKQVMGFEYEEVAAFIAVVGILSITAQTLLLSILMRSIGAKNTILLGLGFQ 285
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 736322654 291 TLEFVVLSVARSAPVLYLSLVVGALGGLAQPAMQGLISRQVGEQEQGRVMGAITSLNSLVGVFGPLLATSVF 362
Cdd:cd17387 286 MLQLAWYGFGSQHWMMWAAGAVAAMSSITFPAISALVSRYADPDQQGAVQGMITGIRGLCNGLGPALFGFVF 357
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
8-390 |
5.56e-28 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 113.48 E-value: 5.56e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 8 LLFILLTALIDVMGIGLIIPVLPGLVKELAGseaGGARFIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVL 87
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLG---LSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 88 DYLLLFFSPNLWWLLVGRLIAGVTGA-SLTVANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLGEHGLRAPFL 166
Cdd:cd17329 78 GFALLGFAHSPWLFAIALVLTGFGGGlFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 167 FAAGLTALNFLYGLLVLPESLPPEKRGAAGGGTLNPFTPLRalteYPLLRGLTLTFVLLGLAGQVIVSTWVLYTEGVLRW 246
Cdd:cd17329 158 AAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLR----DRAFLLFLLASFLISLIYFQLESTLPVYVVEILGL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 247 SPLQNGIAFAVYGLLTAGVQaGLISPFIARFGERRTIMTGLVASTLEFVVLSVARSAPVLYLSLVVGALGG-LAQPAMQG 325
Cdd:cd17329 234 GESLLGLLLALNALLIVLLQ-FPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEmLVFPAVQT 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 736322654 326 LISRQVGEQEQGRVMGAITSLNSLVGVFGPLLATSVFAAGQgagfPGAAFVLGAVLSILGTVLIL 390
Cdd:cd17329 313 LVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLG----PGLPWLILAALGLIAAALLL 373
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
11-355 |
1.47e-27 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 111.74 E-value: 1.47e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 11 ILLTALIDVMGIGLIIPVLPGLVKELAGSeagGARFIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVLDYL 90
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGI---SPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 91 LLFFSPNLWWLLVGRLIAGVTGASL-TVANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLGEH-GLRAPFLFA 168
Cdd:pfam07690 78 LLLFASSLWLLLVLRVLQGLGAGALfPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLfGWRAAFLIL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 169 AGLTALNFLYGLLVLPESLPPEKRGAAGGGTLNPFTPLRALTEYPLlrgLTLTFVLLGLAGQVIVSTWVLYTEGVLRWSP 248
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVL---WLLLALLLFGFAFFGLLTYLPLYQEVLGLSA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 249 LQNGIAFAVYGLLTAGVQ--AGLISPFIARFGERRTIMTGLVASTLEFVVLSVARSAPVLYLSLV-VGALGGLAQPAMQG 325
Cdd:pfam07690 235 LLAGLLLGLGGLLGAIGRllLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLlLGFGFGLVFPALNA 314
|
330 340 350
....*....|....*....|....*....|
gi 736322654 326 LISRQVGEQEQGRVMGAITSLNSLVGVFGP 355
Cdd:pfam07690 315 LVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
8-384 |
5.54e-26 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 107.66 E-value: 5.54e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 8 LLFILLTALIDVMGIGLIIPVLPGLVKELAGSEAGGARFIGVLTAAYAAMQFIFapilGTLSDRFGRRPVLLLSLAGMVL 87
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLY----GPLSDRFGRRPVLLAGLLLFIL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 88 DYLLLFFSPNLWWLLVGRLIAGVTGAS-LTVANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLGEH-GLRAPF 165
Cdd:cd17320 77 ASLLCALASSIEQLLIARFLQGLGAAAgSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFfGWRAIF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 166 LFAAGLTALNFLYGLLVLPESLPPEKRGAAGGGTLNPFTPLRALTEYpLLRGLTLTFVLLGLAGQVIVSTWVLYteGVLR 245
Cdd:cd17320 157 VFLALLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKRVLKNRRF-LGYALALGLSFAGLFAYLAAAPFIYI--EQLG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 246 WSPLQNGIAFAVYGLLTAGvqAGLISPFIA-RFGERRTIMTGLVASTLEFVVLSVARSAP-------VLYLSLVVGALGG 317
Cdd:cd17320 234 LSPAQFGLLFALNAIALIL--GSLLNGRLVrRFGPRRLLRLGLLLLLAAALVLLLAALLGglslwplVAPLFLIFFGFGL 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 736322654 318 LAQPAMQGLISRQvgEQEQGRVMGAITSLNSLVGVFGPLLATSVFAAGQGAgFPGAAFVLGAVLSIL 384
Cdd:cd17320 312 IFPNATSLALEPF--PHVAGTASALLGFLQFLIGALAGALVGLLPNGTALP-MGLLILVLGLLALLL 375
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
48-186 |
4.06e-24 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 96.95 E-value: 4.06e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 48 GVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVLDYLLLFFSPNLWWLLVGRLIAGVTGA-SLTVANAYIADVT 126
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAfALVAGAALIADIY 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 736322654 127 APEDRAKNFGRLGATWGVGFILGPMLGGWLGE-HGLRAPFLFAAGLTALNFLYGLLVLPES 186
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQfLGWRAPFLFLAILALAAFILLAFLLPET 141
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
11-374 |
2.06e-23 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 100.33 E-value: 2.06e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 11 ILLTALIDVMGIGLIIPVLPGLVKELAGSEAGgarfIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVLDYL 90
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQ----LQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 91 LLFFSPNLWWLLVGRLIAGVTGASLT-VANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLGEH-GLRAPFLFA 168
Cdd:cd17321 77 LCALAPSLAFLIAARALQGIGAAAIMpASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELfGWRWIFLIN 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 169 AGLTALNFLYGllvlpeslppekrgaagggtlnpftplralteyPLLRGLTLTFVLLGLAGQVIVSTWVLYTEGVLRWSP 248
Cdd:cd17321 157 VPIGLVALLLA---------------------------------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSP 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 249 LQNGIAFAVYGLLTAgVQAGLISPFIARFGERRTIMTGLVASTLEFVVLS---VARSAPVLYLSLVVGALG-GLAQPAMQ 324
Cdd:cd17321 204 LQAGLALLPLALAML-VAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLAllgADSSVWLLLPGLVLLGLGlGLFATPLT 282
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 736322654 325 GLISRQVGEQEQGRVMGAITSLNSLVGVFGPLLATSVFAAGQGAGFPGAA 374
Cdd:cd17321 283 NAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAGLSANLGDSG 332
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
24-386 |
4.63e-23 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 99.55 E-value: 4.63e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 24 LIIPVLPGLVKELAGSEAGgarfIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVLDYLLLFFSPNLWWLLV 103
Cdd:cd17324 17 VIQGLLPDIARDFGVSVAQ----AGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 104 GRLIAGVTGASLT-VANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLGEH-GLRAPFLFAAGLTALNFLYGLL 181
Cdd:cd17324 93 ARALAGLAHGGFWaIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLlGWRAAFLAIAVLALLAALLLWR 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 182 VLPESLPPEKrgaaggGTLNPFTPLRALTEYPLLRGLTLTFVLLGLAGQVIVSTWVLYTEGVLRWSPLQNGIAFAVYGLl 261
Cdd:cd17324 173 LLPSLPPKKP------GSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGV- 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 262 tAGVQAGLISPFIARFGERRTIMTGLVASTLEFVVLSVARSAP--VLYLSLVVGALGGLAQPAMQGLISrQVGEQEQGRV 339
Cdd:cd17324 246 -AGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPllLLVGLVLWGLGFFAAHSALQTRVL-RLAPEARGLA 323
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 736322654 340 MGAITSLNSLVGVFGPLLATSVFAAGQGAGFPGAAFVLGAVLSILGT 386
Cdd:cd17324 324 SSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
11-390 |
6.01e-23 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 99.04 E-value: 6.01e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 11 ILLTALIDVMGIGLIIPVLPGLVKELAGSEAggarFIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVLDYL 90
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSAS----QLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGAL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 91 LLFFSPNLWWLLVGRLIAGVTGASLTVA-NAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLGEH---GLRAPFL 166
Cdd:cd06174 77 LFAFAPSFWLLLLGRFLLGLGSGLIDPAvLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgfGWRAVFL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 167 FAAGLTALNFLYGLLVLPESLPPEKRGAAGGGTLNPFTPLRALTEYPLLRGLTLTFVLLGLAGQVIVSTWVLYTEGVLRW 246
Cdd:cd06174 157 IAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 247 SPLQNGIAFAVYGLLTAGVQAGLISPFIARFGERRTIMTGLVASTLEFVVLSVARSAPVLYLS-LVVGALGGLAQPAMQG 325
Cdd:cd06174 237 SVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLlLLLGFGLGGLLPLSFA 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 736322654 326 LISRQVGEQEQGRVMGAITSLNSLVGVFGPLLATSVFAAGQGagfPGAAFVLGAVLSILGTVLIL 390
Cdd:cd06174 317 LIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFG---LTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MFSD8 |
cd17326 |
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
42-394 |
1.56e-21 |
|
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 94.97 E-value: 1.56e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 42 GGARFIGVLTAAYAAMQFIFAPILGTLSDRFG-RRPVLLLSLAGMVLDYLL-----LFFSPNLWWLLVGRLIAGVTGASL 115
Cdd:cd17326 33 ATASFFGWVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILIAIVGNILyalaeYFPSNRKYVMLVARFLIGVGAGNV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 116 TVANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGG---WLGEHGL-----------RAPFLFAAGLTALNFLYGLL 181
Cdd:cd17326 113 AVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAaftPIGYPGYvigiklrfnmyTAPAWLMAILGIINIILILF 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 182 VLPEslppekrgaaggGTLNpftplralteypLLR-GLTLTFVLLglagQVIVStwvLYTEGVLRWSP----LQNGIAFA 256
Cdd:cd17326 193 FFKE------------VVCI------------FLFfVVLFIFANL----ETIGT---PLTMDMYGWTReeavLYNGIILA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 257 VYGLLTAGVQAGLISPFIARFGERRTIMTGLVASTLEFVVLsvarsapvLYLSLVVGALGGLAQP----AMQGLISRQVG 332
Cdd:cd17326 242 VSGVLSVLVFLLFKFLSLGLIDERKILLGGLILFFLGFVVT--------LPWGITGVILFGLGYPignvMLYTLYSKILG 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 736322654 333 EQEQGRVMGAITSLNSLVGVFGPLLATSVFAAGQgagfPGAAFVLGAVLSILGTVLILSVLR 394
Cdd:cd17326 314 PKPQGTMQGVLTASGSLARTLGPIFVTAIYTHFG----PRWTWIITLGLLLLAIILLIVFYK 371
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
20-393 |
3.08e-21 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 94.20 E-value: 3.08e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 20 MGIGLIIPVLPGLVKELAGSEAggaRFIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVLDYLLLFFSPNLW 99
Cdd:cd17472 10 LGMFLVLPVLSVYAKSLPGATP---TLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIY 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 100 WLLVGRLIAGvTGASLTVANAYIADVTAPEDRAKNFGRLGATWG----VGFILGPMLGGWLGEHGLrapFLFAAGLTALN 175
Cdd:cd17472 87 GLILGRALQG-SGAISSVVMALLADLTREENRTKAMALIGASIGiafaISMVLGPLLAAHLGVSGL---FLITAILSLVS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 176 FLYGLLVLPESlPPEKRGAAGGGTLnpftpLRALTEYPLLRGLTLTFVLLGLagqVIVSTWVLYTEgVLRWSPLQNGIAF 255
Cdd:cd17472 163 LLILLFFVPDP-PKIVQISEKEKKK-----LKKLLKNKRLLRLDFSIFILHF---VLMAFFYILPL-LLTQLGGGKGQLW 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 256 AVYgLLTAGVQAGLISPFIaRFGERRTIMTGLVASTL------EFVVLSVARSAPVLYLSLVVGALG-GLAQPAMQGLIS 328
Cdd:cd17472 233 KVY-LPAILIGFILMVPFV-IYAEKKGKMKQVFVSSIlliavgFLLLLFAATSLWLLIIGLIIFFIGfNLLEALLPSLVS 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 736322654 329 RQVGEQEQGRVMGAITSLNSLVGVFGPLLatsvfaAGQGAGFPGAAFVLGAVLSILGTVLILSVL 393
Cdd:cd17472 311 KIAPKEYRGTAMGIYNTSQFLGSFLGGAL------GGLLWGLLGYSSVFLTILILALLWLLVSFL 369
|
|
| MFS_SLC46 |
cd17386 |
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ... |
50-393 |
3.91e-21 |
|
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340944 [Multi-domain] Cd Length: 360 Bit Score: 93.88 E-value: 3.91e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 50 LTAAYAAMQFIF----APILGTLSDRFGRRPVLLLSLAGMVLDYLLLFFS------PNLWWLLVGRLIAGVTG---ASLT 116
Cdd:cd17386 31 FYLYMNLMGSIPplfsSLFLGSWSDRYGRKPPLLMSLVGLLLSSLILVLIvyfttvPSVWWFYLSAIPLALFGgftAFLS 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 117 VANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGG-WLGEHGLRAPFLFAAGLTALNFLYGLLvlpeslppekrgaa 195
Cdd:cd17386 111 ASFAYISDISSEKKRTYRMAILEVALGLGGFLGSLLSGhLFKALGYAWSFSISAALLLIALLYILF-------------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 196 gggtlnpftplralteypLLRGLTLTFVLLGLAGQV---IVSTWVLYTEGVLRWSPLQ--NGIAFAVYGLLTAGVQAGLI 270
Cdd:cd17386 177 ------------------FLTLLILLLLAAFLTIFVlsgESDVLYLFVLEKFAWNVKDfsYFSTLGSLIYLTGMLGGVLL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 271 SPFIARFGERRTIMTGLVASTLEFVVLSVARSAPVLYLSLVVGALGGLAQPAMQGLISRQVGEQEQGRVMGAITSLNSLV 350
Cdd:cd17386 239 LRCLLKMSDSTLAMLGLASHILSSLLFAFATNTWMMYLAAVVGMFNGIVGPMIRSILSKLVPKSEQGKIFSLLSVLESLS 318
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 736322654 351 GVFGPLLATSVFAAGQgAGFPGAAFVLGAVLSILGTVLILSVL 393
Cdd:cd17386 319 PLVASPIYNNIYKATL-TTFPGFFFLLSAGLLLIPVILIGVVY 360
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
1-357 |
7.01e-20 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 90.30 E-value: 7.01e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 1 MPRRPPALLFILLTALIDVMGIGLII--PVLPGLVKELAGSEAggarFIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVL 78
Cdd:COG0738 1 MSKKNYRRALIAIYLLFFLWGFATALwgPLIPALKDAFGLSDA----QAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 79 LLSLAGMVLDYLLLFFSPNLWWLLVGRLIAGVTGASL-TVANAYIADVTaPEDRAKNFGRLGATWGVGFILGPMLGGWLG 157
Cdd:COG0738 77 LLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLdVAANPYVAALG-PETAASRLNLLHAFFSLGALLGPLLGGLLI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 158 EHGL----RAPFLFAAGLTALNFLYGLLV-LPESLPPEKRGAAGGGTlnpftpLRALTEYPLLRGLTLTFVLLGLAGQVI 232
Cdd:COG0738 156 LLGLslswHLPYLILAVLLLLLALLFLRSkLPEIEEEEEEAAGSAAS------LKSLLKNPRLLLGGLAIFLYVGAEGAI 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 233 VSTWVLYTEGVLRWSPLQNGIAFAVY-GLLTAGVQAGliSPFIARFGERRTIMTGLVASTLEFVVLSVARSAPVLYLSLV 311
Cdd:COG0738 230 GDWLPLYLKDVLGLSEATAALGLSLFwGGMTIGRFLG--GFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLA 307
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 736322654 312 VGALG-GLAQPAMQGLISRQVGEQeQGRVMGAITSLNSLVGVFGPLL 357
Cdd:COG0738 308 LVGLGlSLMFPTIFSLALDGLGKR-TAAAVSAVLIMGIVGGAIGPPL 353
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
8-391 |
7.38e-20 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 90.37 E-value: 7.38e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 8 LLFILLTALIDVMGIGLIIPVLPGLVKELAGSEAggarFIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGM-- 85
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSAL----LVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRal 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 86 ---VLDYLLLFFSPNLWWLLVGRLIAGVTGASLTVA-NAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLGEHGL 161
Cdd:cd06173 77 laaVLALLALLGSLSLWLLLVLAFLLGIASAFFGPArQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 162 RAPFLFAAGLTALNFLYGLLVLPESLPPEKRGAAGGGTLNPFTPLRALTEYPLLRGLTLTFVLLGLAGQVIVSTWVLYTE 241
Cdd:cd06173 157 PGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAK 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 242 GVLRWSPLQNGIAFAVYGlLTAGVQAGLISPFIARFGERRTIMTGLVASTLEFVVLSVARSAPVLYLSLVV-GALGGLAQ 320
Cdd:cd06173 237 EVLGGGAAGYGLLLAAFG-VGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLlGLAGGLFN 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 736322654 321 PAMQGLISRQVGEQEQGRVMGAITSLNSLVGVFGPLLATSVFAagqgAGFPGAAFVLGAVLSILGTVLILS 391
Cdd:cd06173 316 VPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLAD----ALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
3-181 |
1.30e-19 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 89.56 E-value: 1.30e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 3 RRPPALLFILLTALIDVMGIGLIIPVLPGLVKELAGseaGGARFIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSL 82
Cdd:cd17325 196 LRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGG---LSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGL 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 83 AGMVLDYLLLFFSPNLWWLLVGRLIAGVTGASLTVA-NAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLGEH-G 160
Cdd:cd17325 273 LLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPAtLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAfG 352
|
170 180
....*....|....*....|.
gi 736322654 161 LRAPFLFAAGLTALNFLYGLL 181
Cdd:cd17325 353 FATPFLAAAALLLLAAVLFLL 373
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
24-390 |
1.47e-19 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 89.17 E-value: 1.47e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 24 LIIPVLPGLVKELAGSEAGgarfIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVLDYLLLFFSPNLWWLLV 103
Cdd:cd17504 14 MLSPALPTIQREFGTSAAA----VSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 104 GRLIAGVTGASLTVANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLGEH-GLRAPFLFAAGLTALnflygllv 182
Cdd:cd17504 90 GRALQGIGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHlGWRWIFWTAAPVAVL-------- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 183 lpeslppekrgaagGGTLNPFTPLRALTEYPLLrGLTLTFVLLGLAGQVIVSTWVLYTEGVlRWSPLQNGIAFAVYGLLT 262
Cdd:cd17504 162 --------------LAALVPLIDLRLLRRRNVL-LANITALLAGFGMFMVFQLLPQLLQLP-TPTGFGLGITEAGLLLLP 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 263 AGVQAGLISPF----IARFGERRTIMTGLVASTLEFVVLSVARSAPVLY--LSLVVGALGGLAQPAMQGLISRQVGEQEQ 336
Cdd:cd17504 226 GALVMLIAGPLagrlIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALvvALLLIGIGLGLAFASLPNIVVESVPPDRT 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 736322654 337 GRVMGAITSLNSLVGVFGPLLATSVFAAGQGAGFPG---------AAFVLGAVLSILGTVLIL 390
Cdd:cd17504 306 GIATGMNTVLRTIGSAIGPAIAGAILTTYTVSITSGgvptegayvLAFLIGAALALAALLLSL 368
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
26-390 |
4.55e-19 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 88.05 E-value: 4.55e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 26 IPVLPGLVKELAGSeaggARFIGVLTAAYAAMQFIFAPILGTLSDRFGRR-PVLLLSLAGMVLDYLLLFFSPNLWWLLVG 104
Cdd:cd17490 16 VPFLSPYAESLGAS----LSMIGIILGAYGISQMLLRIPLGILSDRIGKRkLFIIIGLLFTVLASLIMILFPSPWGLLIA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 105 RLIAGVTGASLTVANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLGEH-GLRAPFLFAAGLTALNFLYGLLVL 183
Cdd:cd17490 92 RFLSGIAAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHfGMRAPFLLAALAGVLGFILSLFIK 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 184 PESLPPEKRgaagggtLNPFTPLRALTEYPLLrgltLTFVLLGLAGQVI----VSTWVLYTEGVLRWSPLQNGIAFAVYG 259
Cdd:cd17490 172 EERREKKPV-------LTELKELLSVLKDKKL----LFFSLLAILQQMItfstTFGFTPLIAKQLGASSFQLGLLSIIYL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 260 LLTAGVQAGLISPFIARFGERRTIMTGLVASTLEFVVLSVARSAPVLYLSLVVGALG-GLAQPAMQGLISRQVGEQEQGR 338
Cdd:cd17490 241 LPNALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGtGILFPLLMSLSIEGVPAEQRST 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 736322654 339 VMGAITSLNSLVGVFGPLLATSVfaaGQGAGFPGAAFVLGaVLSILGTVLIL 390
Cdd:cd17490 321 AMGFFQAIYALGMFLGPVLVGII---SEAFGLQTGFFVIG-VIALLAAILSL 368
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
47-402 |
1.53e-18 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 86.47 E-value: 1.53e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 47 IGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVLDYLLLFFSPNLWWLLVGRLIAGVT-GASLTVANAYIADV 125
Cdd:COG2223 42 LGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGgGGSFAVGIALVSKW 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 126 TAPEDRAKNFGRLGATWGVGFILGPMLGGWL-GEHGLRAPFLFAAGLTALNFLYGLLVLPESLPPEKRGAAGggtlnPFT 204
Cdd:COG2223 122 FPPDRRGLALGLAAGGGNLGAAVAAFLAPLLiAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKA-----SLR 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 205 PLRALTEYPLLRGLTLTFVLLGLAGQVIVSTWVLYTEGVLRWSPLQNGIAFAVYGLLTAGVQAgLISPFIARFGERRTIM 284
Cdd:COG2223 197 DQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRP-LGGWLSDRIGGRRVLL 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 285 TGLVASTLEFVVLSVARSAPVLY--LSLVVGALGGLAQPAMQGLISRQVGEQEQGRVMGAITSLNSLVGVFGPLLATSVF 362
Cdd:COG2223 276 IVFALMALGLLLLALALGSLWLFlvLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALL 355
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 736322654 363 AAgqgAGFPGAAFVLGAVLSILGTVLILSVLRGIPGTGRA 402
Cdd:COG2223 356 DA---TGSYTAAFLVFAVLALVALVLTLLLYRRPRRAAAA 392
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
2-394 |
2.27e-18 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 85.69 E-value: 2.27e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 2 PRRPPALLFILLTALIDVMGIGLIIPVLPGLVKELAGSEAGgarfIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLS 81
Cdd:COG2271 6 RYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQ----LGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 82 LAGMVLDYLLLFFSPNLWWLLVGRLIAGV-TGASLTVANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLGEH- 159
Cdd:COG2271 82 LLLWGLATLLFGFATSFWQLLLLRFLLGLgEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAf 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 160 GLRAPFLFAAGLTALNFLYGLLVLpeslppekrgaagggtlnpftplralteypllrglTLTFVLLGLAGQVIVSTWVLY 239
Cdd:COG2271 162 GWRAAFLILGLPGLLLALLRFWLL-----------------------------------ALAYFLVYFALYGFLTWLPTY 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 240 TEGVLRWSPLQNGIAFAVYGLltAGVQAGLISPFIARFGERRTIMTGLVASTLEFVVLSVARSAPVLYLSLVVGALGGLA 319
Cdd:COG2271 207 LVEVRGLSLAQAGLLLSLPFL--AGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFG 284
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 736322654 320 QPAMQGLISRQVGEQEQGRVMGAITSLNSLVGVFGPLLATSVFAAGQGAGFPGAAFVLGAVLSILGTVLILSVLR 394
Cdd:COG2271 285 LGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLR 359
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
1-289 |
2.33e-17 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 81.78 E-value: 2.33e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 1 MPRRPPALLFILLTALIDVMGIGLIIPVLPGLVKELAGSEAGgarfIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLL 80
Cdd:COG0477 9 TRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQ----LGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 81 SLAGMVLDYLLLFFSPNLWWLLVGRLIAGVTGASLT-VANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLGEH 159
Cdd:COG0477 85 GLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMpGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 160 -GLRAPFLFAAGLTALNFLYGLLVLPESLPPEKRGAAGGGTLNPFTPLRALTEYPLLRGLTLTFVLLGLAGQVIVSTWVL 238
Cdd:COG0477 165 lGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLA 244
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 736322654 239 YTEGVLRWSPLQNGIAFAVYGLLTAGVQAGLISPFIARFGERRTIMTGLVA 289
Cdd:COG0477 245 LLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
24-363 |
3.15e-17 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 82.66 E-value: 3.15e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 24 LIIPVLPGLVKELAGSeagGARFIGVLTAAYAAMQFIFA----PILGTLSDRFGRRPVLLLSLAGMVLDYLLLFFSPNLW 99
Cdd:PRK09874 32 LVMPFLPLYVEQLGVT---GHSALNMWSGLVFSITFLFSaiasPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIW 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 100 WLLVGRLIAGVTGASLTVANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLGEH-GLRAPFLFAAGLTALNFLY 178
Cdd:PRK09874 109 QFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSyGLRPVFFITASVLFLCFLV 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 179 GLLVLPESLPPekrgAAGGGTLNPFTPLRALTEYPLLRGLTLTFVLLGLAGQVIVSTWVLYtegVLRWSPLQNGIAFaVY 258
Cdd:PRK09874 189 TLFCIRENFQP----VSKKEMLHMREVVTSLKNPKLVLSLFVTTLIIQVATGSIAPILTLY---VRELAGNVSNIAF-IS 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 259 GLLTA--GVQAGLISPFIARFGER----RTIMTGLVASTLEFVVLSVARSAPVL-YLSLVVGALGGLAQPAMQGLISRQV 331
Cdd:PRK09874 261 GMIASvpGVAALLSAPRLGKLGDRigpeKILITALIFSVLLLIPMSFVQTPLQLgILRFLLGAADGALLPAVQTLLVYNS 340
|
330 340 350
....*....|....*....|....*....|..
gi 736322654 332 GEQEQGRVMGAITSLNSLVGVFGPLLATSVFA 363
Cdd:PRK09874 341 SNQIAGRIFSYNQSFRDIGNVTGPLMGAAISA 372
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
11-364 |
3.81e-16 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 79.16 E-value: 3.81e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 11 ILLTALIDVMGIGLIIPVLPGLVKELAGSEAGgarfIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVLDYL 90
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDT----VQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 91 LLFFSPNLWWLLVGRLIAGVTGASLT-VANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLGEH-GLRAPFLFA 168
Cdd:cd17503 77 LCGLAPNLASLIIFRILQGFGGGVLIpLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNlSWRWIFYIN 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 169 AGLTALNFLygllvlpeslppekrgaagggtLNPFTPLRALTEypllRGLTLTFVLLGLAGQVIVSTWV---LYTEGVLR 245
Cdd:cd17503 157 LPIGILALL----------------------LAPLLDLRLFKD----RNFTLGLLLSFLLGLGLFGAMFllpLYLQNVLG 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 246 WSPLQNGIAFAVYGLLTAGVqAGLISPFIARFGERRTIMTGLV---ASTLEFVVLSVARSAPVLYLSLVVGALG-GLAQP 321
Cdd:cd17503 211 YSAFESGLVLAPGGLASAIL-SPLVGRLLDKFGPRLLLLAGLLllaLGTLLLAFLTPDTSLWLIILPLFIRGLGmGLVFM 289
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 736322654 322 AMQGLISRQVGEQEqgrvMGAITSLNSLVGVFGPLLATSVFAA 364
Cdd:cd17503 290 PLNTLALNSLPPEQ----IGDATALFNTIRQLGGSIGTALLAT 328
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
38-159 |
1.78e-15 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 76.83 E-value: 1.78e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 38 GSEAGGARFIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVLDYLLLFFSPNLWWLLVGRLIAGVTGASL-T 116
Cdd:cd17502 23 VAEFGGLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLmS 102
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 736322654 117 VANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLGEH 159
Cdd:cd17502 103 LAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDH 145
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
37-392 |
3.63e-15 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 76.73 E-value: 3.63e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 37 AGSEAGGARFIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLL--SLAGMVLDYLLLFFSPNLWWLLVGRLIAGVTG-- 112
Cdd:COG2270 44 LGDPAAATALWGYALAIAGLLVALLAPVLGAIADRSGRKKPFLAffTLLGVLATAALFFVAPGGLWLGLLLFVLANIGfe 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 113 ASLTVANAYIADVTAPEDRAKNFGRlGATWG------------VGFILGPMLGGWLGEHGLRAPFLFAAGLTALNFLYGL 180
Cdd:COG2270 124 GSLVFYNAFLPDIATPEEIGRVSGL-GWALGylggvllllinlALFLKPEAFGLPDAGEAVRISFLLTALWWLLFALPLF 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 181 LVLPESlPPEKRGAAGGGTLNPFTPL----RALTEYPLLRGLTLTFVLLGLAGQVIVSTWVLYTEGVLRWSPLQNGIAFA 256
Cdd:COG2270 203 LFLPER-PRPGPAPPRGAVRAGFRELrrtlRELRRYRDLLRFLLAYFFYRDGVQTVIAFAGIYAAGVLGFSTTELIVFGL 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 257 VyGLLTAGVQAGLISPFIARFGERRTIMTGLVASTLEFVVLSVARSAPVLY-LSLVVGALGGLAQPAMQGLISRQVGEQE 335
Cdd:COG2270 282 L-VQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWiLGLLIGLVMGGIQALSRSLLARLIPPGR 360
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 736322654 336 QGRVMGAITSLNSLVGVFGPLLatsVFAAGQGAGFPGAAFVLGAVLSILGTVLILSV 392
Cdd:COG2270 361 EAEFFGLYALSGKAASFLGPLL---FGLVTQLTGSQRLGILSLIVFFVIGLVLLLRV 414
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
5-178 |
5.91e-15 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 75.76 E-value: 5.91e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 5 PPALLFILLTALIDVMGIGLIIPVLPGLVKELAGSEAGGARFIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAG 84
Cdd:cd17391 200 PSLLISLFVTTFIIQLANQSIEPILTLYIRQLMGDASNLAFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLA 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 85 MVLDYLLLFFSPNLWWLLVGRLIAGV-TGASLTVANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLGEH-GLR 162
Cdd:cd17391 280 SALLYIPQAFVQTPWQLGILRFLLGLaTGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHfGYR 359
|
170
....*....|....*.
gi 736322654 163 APFLFAAGLTALNFLY 178
Cdd:cd17391 360 AVFVVTALLVLLNAIW 375
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
2-394 |
6.13e-15 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 75.68 E-value: 6.13e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 2 PRRPPALLFILLTALIDVMGIGLIIPVLPGLVKELAGSEAGgarfIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLS 81
Cdd:COG2807 14 AGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQ----AGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 82 LAGMVLDYLLLFFSPNLWWLLVGRLIAGVTGASLTVANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLGEH-G 160
Cdd:COG2807 90 LLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAAlG 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 161 LRAPFLFAAGLTALNFLYGLLVLPESLPPEKRGAAGggtlnpfTPLRALTEYPLLRGLTLTFVLLGLAGQVIVsTWVLYT 240
Cdd:COG2807 170 WRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAA-------ASLRSLWRSPLAWLLTLFFGLQSLLYYAVV-AWLPPI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 241 EGVLRWSPLQNGIAFAVYGLltAGVQAGLISPFIA-RFGERRTIMTGLVASTL-EFVVLSVARSAPVLYLSLVVGALGGL 318
Cdd:COG2807 242 LRDAGLSAATAGLLLSLFQL--AGIPGSLLVPLLAdRLGDRRPLLLLLGLLGLaGLLGLLLAPGSLPWLWAVLLGLGQGG 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 736322654 319 AQPAMQGLISRQVGEQEQ-GRVMGAITSLNSLVGVFGPLLATSVFAAGQGagfPGAAFVLGAVLSILGTVLILSVLR 394
Cdd:COG2807 320 LFPLALTLIGLRARTPAEaAALSGMAQSVGYLLAALGPLLVGALHDATGS---WTAALLLLAALAVLMLVAGLLAGR 393
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
11-390 |
2.15e-14 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 74.12 E-value: 2.15e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 11 ILLTALIDVMGIGLIIPVLP-GLVKELAGSEAggarFIGVLTAAYAAMQFIFAPILGTLSDR-FGRRPVLLLSLAGMVLD 88
Cdd:cd17471 1 LLLATLLTGLAGAFVLPYLSlFLTEELGASPL----QIGIFMTLSALSGIVVSQWLGRLSDRgGDRKPLILLALLAGALG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 89 YLLLFFSPNLWWLL-VGRLIAGVTGASLTVANAYI---ADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWL-GEHGLRA 163
Cdd:cd17471 77 YLLFAFLRNYWVLLlVGVVLLSLGAAAFPQLFALAreyADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLlDVLGFTG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 164 PFLFAAGLTALNFLYGLLVLPESLPPEKRGAAGGGTLNPFTPLRALTeypllrgLTLTFVLLGLAGQVIVSTWVLYTEGV 243
Cdd:cd17471 157 LFLLAALLYLVVALLVLFLLPSVKPPAQKATPASSLVKAPVNRRLLL-------LFAAFTLLFAANSMYIIAMPLYVTNE 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 244 LRWSPLQNGIAFAvyglLTAGVQ------AGLISpfiARFGERRTIMTGLVASTLEFVVLSVARSAPVLYL-----SLVV 312
Cdd:cd17471 230 LGGSESWVGLLFG----LAAALEipimllAGLLA---KRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIAlqllnAIFI 302
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 736322654 313 GALGGLAQPAMQGLISRQvgeqeqgrvMGAITSLNSLVGVFGPLLATSVFAAGQGAGFPGAAFVLGAVLSILGTVLIL 390
Cdd:cd17471 303 GITAGLGISYFQDLMPGQ---------PGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
11-384 |
4.12e-14 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 72.98 E-value: 4.12e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 11 ILLTALIDVMGIGLIIPVLPGLVKELAGSEAggarFIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVLDYL 90
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTA----LIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 91 LLFFSPNLWWLLVGRLIAGVTGASL-TVANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLGEHGLrAPFLFAA 169
Cdd:cd17477 77 LLALTDSPWVWFLLRFVMGIGLAGLfVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGA-LPFLIAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 170 GLTALNFLYGLLVLPESLPPEKRGAAGGGTLNPFTPLralteypllrGLTLTFVlLGLAGQVIVSTWVLYTEGVLrWSPL 249
Cdd:cd17477 156 VLLLLALVPLLLTRRAAPEIEEAESISLRRLLRIAPL----------ALLGAFV-AGFLEGAFYSLLPLYGLRLG-LSVA 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 250 QNGIAFAVYGLLTAGVQAgLISPFIARFGERRTIM-TGLVASTLEFVVLSVARSAPVLY-LSLVVGALGGLAQPAMQGLI 327
Cdd:cd17477 224 QAALLLAAFVLGGLLLQW-PLGWLADRFDRRRVLLgCALLGALAALLLPLVPGLPLALLvLLFLWGGAAGPLYTLALALA 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 736322654 328 SRQVGEQEQGRVMGAITSLNSLVGVFGPLLATSVFAAGQGAGFPGAAFVLGAVLSIL 384
Cdd:cd17477 303 GDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLF 359
|
|
| MFS_SLC46A1_PCFT |
cd17449 |
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major ... |
64-389 |
4.71e-14 |
|
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 1 (SLC46A1) is also called proton-coupled folate transporter (PCFT), G21, or heme carrier protein 1 (HCP1). It functions in two ways: as an intestinal proton-coupled high-affinity folate transporter that facilitates the absorption of folates across the brush-border membrane of the small intestine; and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. It displays a higher affinity for folate than heme. It is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of function mutations in the SLC46A1 gene results in the autosomal recessive disorder "hereditary folate malabsorption" (HFM), characterized by severe systemic and cerebral folate deficiency. SLC46A1 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341007 [Multi-domain] Cd Length: 425 Bit Score: 73.30 E-value: 4.71e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 64 ILGTLSDRFGRRPVLLLSLAGMVLD---YLL-LFFSPNLWWLLVGRLIAGVTG---ASLTVANAYIADVTAPEDRAKNFG 136
Cdd:cd17449 84 LLGPWSDSVGRRPVLILPSLGLALQaavYLLvMYLQLHVAYFLIGRILSGLLGdfnGILAGCFAYVADVSDRRSRTFRVA 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 137 RLGATWGVGFILGPMLGG-WLGEHGLRAPFLFAAGLTALNFLYGLLVLPESLPPEKrgAAGGGTLNPFTPLRALTEYPLL 215
Cdd:cd17449 164 VLEACLGLAGMLASIIGGqWRKAQGYINPFWLVLALNLAAALYAAFCVGESVKEPK--SARLFTTRHHQSVVRLYVAPAP 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 216 RGLTLTFVLLGLAGQVIVST-------WVLYTEGV-LRWSPLQNGIAFAVYGLLTAGVQAGLiSPFIARFGERRTIMTGL 287
Cdd:cd17449 242 NGSRRKLALYSLALFVVVTVhfgakdlLVLYELSSpLCWDSDLIGYGSAAEHLTYLSSLLGL-RLLQLCLEDTWVAEIGL 320
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 288 VASTLEFVVLSVARSAPVLYLSLVVGALGGLAQPAMQGLISRQVGEQEQGRVMGAITSLNSLVGvfgpLLATSVFAAGQG 367
Cdd:cd17449 321 ISNISGLVVISVATTTPLMFTGYGLLFLSMATTPVIRAKLSKLVRETEQGALFASVACVEGLCS----LVATGIFNSLYP 396
|
330 340
....*....|....*....|....*...
gi 736322654 368 A------GFPgaaFVLGAVLSILGTVLI 389
Cdd:cd17449 397 AtlhfmkGFP---FLFGAALLLIPAGII 421
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
11-185 |
3.05e-13 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 70.30 E-value: 3.05e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 11 ILLTALIDVMGIGLIIPVLPGLVKELAGSEAGGARFIGVLTAAYAAMQFIFAPilgtLSDRFGRRPVLLLSLAGMVLDYL 90
Cdd:cd17323 4 ISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAP----LSELYGRRPVYLVSLFIFVIFQI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 91 LLFFSPNLWWLLVGRLIAGVTGAS-LTVANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLGEH-GLRAPFLFA 168
Cdd:cd17323 80 GCALAPNIAMLIILRFLQGFFGSSpLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSlGWRWIFWFL 159
|
170
....*....|....*..
gi 736322654 169 AGLTALNFLYGLLVLPE 185
Cdd:cd17323 160 AIISGFCLILIFLFLPI 176
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
47-390 |
3.70e-13 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 70.70 E-value: 3.70e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 47 IGVLTAAYAAMQFIFAPILGTLSDRFG-----RRPVLLLSLAGMVLDYLLLFFSPN------LWWLLVGRLIAGVTGASL 115
Cdd:COG2211 48 VGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAIPLALSFVLLFTAPDlsptgkLIYALVTYLLLGLAYTLV 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 116 TVA-NAYIADVTA-PEDRAK--NFGRLGATWG--VGFILGPMLGGWLGE---HGLRAPFLFAAGLTALNFLYGLLVLPES 186
Cdd:COG2211 128 NIPySALGAELTPdYEERTRlsSWRFAFAGLGglLASVLPPPLVAAFGGdaaLGYRLTALIFAVLGLLAFLLTFFGTKER 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 187 LPPEKRgaagggTLNPFTPLRALTEYPLLRGLTLTFVLLGLAGQVIVSTWVLYTEGVLRWSPLQNGIAFAVYGLLTAGVq 266
Cdd:COG2211 208 PVPEEE------KVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLG- 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 267 AGLISPFIARFGERRTIMTGLVASTLEFVVLSVAR--SAPVLYLSLVVGALG-GLAQPAMQGLISRQVGEQEQ---GRVM 340
Cdd:COG2211 281 APLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGlGAILVLPWAMLADVVDYDEWktgRRRE 360
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 736322654 341 GAITSLNSLV---------GVFGPLLATSVFAAGQG------AGFPGAAFVLGAVLSILGTVLIL 390
Cdd:COG2211 361 GLYFGIFTFAiklgqalagALAGLLLALFGYVAGAAqspsalTGIRLLFFLLPAVLLLLAALLLL 425
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
46-174 |
7.62e-13 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 69.11 E-value: 7.62e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 46 FIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVLDYLLLFFSPNLWWLLVGRLIAGV-TGASLTVANAYIAD 124
Cdd:cd17370 235 LIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLyMGAQESIERAAVAD 314
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 736322654 125 VTAPEDRAKNFGRLGATWGVGFILGPMLGGWLGEH-GLRAPFLFAAGLTAL 174
Cdd:cd17370 315 LVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLiSPSAAFLFSAVLALI 365
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
8-387 |
1.17e-12 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 68.40 E-value: 1.17e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 8 LLFILLTALIDVMGIGLIIPVLPGLVKELagSEAGGARFIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVL 87
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEF--SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 88 DYLLLFFSPNLWWLLVGRLIAGV-TGASLTVANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWL-----GEHGL 161
Cdd:cd17316 79 ATLLIGLLPTPILLLVLRFLQGIgIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLipllsGDWGW 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 162 RAPFLFAAGLTALNFLYGLLVLpeslppekrgaagggtlnpftplralteypllrgLTLTFVLLGLAGQVIVSTWVLYTE 241
Cdd:cd17316 159 RILFLIGALPALLALLLRRRTL----------------------------------LLILLWFFISFGYYGLTTFLPTYL 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 242 GVLRWSPLQNGIAFAVYGLLTAGVQAGLISPFIARFGERRTIMTGLVASTLEFVVLSVARSAP---VLYLSLVVGALGGL 318
Cdd:cd17316 205 QTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSptlLLLLLFILSFFVGG 284
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 736322654 319 AQPAMQGLISRQVGEQEQGRVMGAITSLNSLVGVFGPLLATSVFAAGQGAGFPGAAFVLGAVLSILGTV 387
Cdd:cd17316 285 VWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
48-313 |
5.81e-12 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 66.88 E-value: 5.81e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 48 GVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVLDYLLLFFSPNLWWLLVGRLIAGVTGASL-TVANAYIADVT 126
Cdd:cd17328 37 GLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYsPIAPTIIADLF 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 127 APEDRAKNFGRLGATWGVGFILGPMLGGWLGEH--GLRAPFLFAAGLTALNFLYGLLVLPEslPPEKRGAAGGGTLNPFT 204
Cdd:cd17328 117 PKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQAtgGWRWAFRVTGVLGVLLAILLLLFVRE--PPRGAAEGGVMAKSTAT 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 205 PLRALTEYpLLRGLTLTFVLLGLAGQVIVS-----TWVLYTEGVLRWSPLQNGIAFAVYGLLT--AGVQAGLISPFIARF 277
Cdd:cd17328 195 SFLADLKA-LAKNPSFILSTLGFTAVSFVTgalafWAPTFFLRAFGVGDLSSADVGLIFGAITciAGVLGVLLGGILADR 273
|
250 260 270
....*....|....*....|....*....|....*.
gi 736322654 278 GERRTIMTGLVAStlefvVLSVARSAPVLYLSLVVG 313
Cdd:cd17328 274 LRRKTPRADPLVC-----AVGLLAAAPFLFLALVLA 304
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
3-156 |
2.96e-11 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 64.54 E-value: 2.96e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 3 RRPPALLFILLTALIDVMGIGLIIPVLPGLVKELAGSEAGgarFIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSL 82
Cdd:COG2211 225 LKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAA---LVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGL 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 83 AGMVLDYLLLFFSP--NLWWLLVGRLIAGVT-GASLTVANAYIADVtAPEDRAKN--------FGRLGATWGVGFILGPM 151
Cdd:COG2211 302 LLAALGLLLLFFLGpgNLWLLLVLAALAGIGlGAILVLPWAMLADV-VDYDEWKTgrrreglyFGIFTFAIKLGQALAGA 380
|
....*
gi 736322654 152 LGGWL 156
Cdd:COG2211 381 LAGLL 385
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
7-358 |
3.15e-11 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 64.30 E-value: 3.15e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 7 ALLFILLTALIDVMGIGLIIPVLPGLVKELAGSEAGGARfigVLTAAYAAMQFiFAPILGTLSDRFGRRPVLLLSLAGMV 86
Cdd:TIGR00895 18 AIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGF---LFSAGLIGMAF-GALFFGPLADRIGRRRVLLWSILLFS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 87 LDYLLLFFSPNLWWLLVGRLIAGV-TGASLTVANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLG-EHGLRAP 164
Cdd:TIGR00895 94 VFTLLCALATNVTQLLILRFLAGLgLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIpVFGWRSL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 165 FLFAAGLTALNFLYGLLVLPESLP--PEKRGAAGGGTLNPFTP------LRALTEYPLLRGLTLTFVLLGLAGQVIVST- 235
Cdd:TIGR00895 174 FYVGGIAPLLLLLLLMRFLPESIDflVSKRPETVRRIVNAIAPqmqaeaQSALPEQKSTQGTKRSVFKALFQGKTARITv 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 236 --WVLYT------EGVLRWSPL---QNGIAFAVYGLLTAGVQAG-----LISPFIARFGERRTIMTGLVASTLEFVVLSV 299
Cdd:TIGR00895 254 llWLLYFmllvgvYFLTNWLPKlmvELGFSLSLAATGGALFNFGgvigsIIFGWLADRLGPRVTALLLLLGAVFAVLVGS 333
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 736322654 300 ARSAPVLYLSL--VVGALGGLAQPAMQGLISRQVGEQEQGRVMGAITSLNSLVGVFGPLLA 358
Cdd:TIGR00895 334 TLFSPTLLLLLgaIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILA 394
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
47-392 |
3.55e-11 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 64.14 E-value: 3.55e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 47 IGVLTAAYAAMQFIFAPILGTLSDRFGRRP-VLLLSLAGMVLDYLLLFF-SPNLWWLLVGRLIAGV-TGASLTVANAYIa 123
Cdd:cd17335 34 IGILIGIRPFVRFLSAPLWGALADRFGKRKaLLLLSLLAAVLFFLSLFFvAQIFWLLLLLVILGAFfSAPVVPLVDSIT- 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 124 dVTAPEDRAKNFG--RLGATWGVG---FILGPMLGGWLGEHGLRAPFLFAAGLTALNFLYGLLVLPESLPPEKRGAAGGG 198
Cdd:cd17335 113 -LQYLGEERERYGkqRLWGSIGFGiaaLLVGILIDRSSTYKNYTIAFYVFAVLMLLALLLALKFPFRPKHPEPNENTGGL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 199 tlnpftpLRALTEYPLLRGLTLTFvLLGLAGQVIVSTWVLYTEGvLRWSPLQNGIAFAVYGLLTAGVQAGLiSPFIARFG 278
Cdd:cd17335 192 -------LALLRNPRVLAFLLVAF-LMGFGHGLIYSFLFWHLQD-LGGSKTLIGLLWTVGVVSEIPFFFFS-SRLIQRFG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 279 ERRTIMTGLVASTLEFVVLSVARSAPVLYLSLVV-GALGGLAQPAMQGLISRQVGEQEQGRVMGAITSL-NSLVGVFGPL 356
Cdd:cd17335 262 HVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLhGLTFALVWAAAVSYASAAAPPGLRATAQGLLQGLyFGLGGGLGSL 341
|
330 340 350
....*....|....*....|....*....|....*.
gi 736322654 357 LATSVFAAGQGAGfpgaAFVLGAVLSILGTVLILSV 392
Cdd:cd17335 342 IGGYLYEAFGART----TFRFFAIAALAGLLAFFLI 373
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
47-392 |
4.67e-11 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 63.83 E-value: 4.67e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 47 IGVLTAAYAAMQFIFA---PILGTLSDRFGRRPVLLLSLAGMVLDYLLLFFSPNLWWLLVGRLIAGVTGASLT--VANAY 121
Cdd:cd17355 37 RAVISLAFTVGLLAFGlaqPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLaaVAFAT 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 122 IADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLGEH-GLRAPFL-FAAGLTALNFLYGLLVLPESLPPEKRGAAGGGT 199
Cdd:cd17355 117 VAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAfGWRTALLvLALLALLVLVPVLLLLRRRPADLALRAYDDASP 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 200 LNPFTPLRALTEYPLLRGLTLTFVLLGLAGQVIVSTWVLYtegvLRWSPLQNGIAFAVYGLLTAGVQAG--LISPFIARF 277
Cdd:cd17355 197 ASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPY----LADRGISPAAAAVALALIGLFNIVGrlLSGWLGDRY 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 278 GERRTIMTGLVASTLEFVVLSVARSAPVLYL--SLVVGALGGLAQPAMQGLISRQVGEQEQGRVMGAITSLNSLVGVFGP 355
Cdd:cd17355 273 SPRRLLAASYALRALGLALLLLLPFPPLALLlfAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGP 352
|
330 340 350
....*....|....*....|....*....|....*..
gi 736322654 356 LLATSVFAAgqgAGFPGAAFVLGAVLSILGTVLILSV 392
Cdd:cd17355 353 WLGGLLYDR---TGSYTAAWALAVALGLIAALLVLPI 386
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
6-313 |
7.11e-11 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 63.17 E-value: 7.11e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 6 PALLFILLTALIDVMG---IGLIIPVLPGLVKELAGSeaggARFIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSL 82
Cdd:TIGR00710 2 SAKAFALLLGCLSILGplgIDMYLPAFPEIAADLSTP----ASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 83 AGMVLDYLLLFFSPNLWWLLVGRLIAGVTG-ASLTVANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLGEH-G 160
Cdd:TIGR00710 78 FIFALSSLGLALSNNIETLLVLRFVQAFGAsAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWlS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 161 LRAPFLFAAGLTALNFLYGLLVLPESLPPEKRGAAGGGTLNPFTPLRALTEypLLRGLTLTFVLLGLAGQVIVSTWVLyt 240
Cdd:TIGR00710 158 WHAIFAFLSLAGILLSALIFFILPETLPYEARIQISTYFETFLLLLKSKMF--WGYALIYGASFGGFFAFFSGAPFVY-- 233
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 736322654 241 EGVLRWSPLQNGIAFAVYGlLTAGVQAGLISPFIARFGERRTIMTGLVASTLEFVVLSVARSAPVLYLSLVVG 313
Cdd:TIGR00710 234 IDIMGVSPSVFGLLFALNI-IAMIFGGFLNGRFIKKWGAKSLLRMGLILFAVSAVLLEITAILGLGSWAMIIG 305
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
23-323 |
7.88e-11 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 62.96 E-value: 7.88e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 23 GLIIPVLPGLVKELAGSEAGgarfIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVLDYLLLFFSPNLWWLL 102
Cdd:cd17478 13 GFLPALLPLLIAKLGLSYAQ----AGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 103 VGRLIAGVTGASLTVANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLGEHGLRAPFLFAAGLTALNFLYGLLV 182
Cdd:cd17478 89 LLVALAGIGSAAFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLR 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 183 LPESLPPEKRGAAGGGTlnpFTPLRALTEYPLLRgLTLTFVLLGLAGQVIVSTWVLYTEGVLrWSPLQNGIAFAVygLLT 262
Cdd:cd17478 169 LRPLKKPEAKKAAAKSS---ARSTLKGVWRALLL-LLIIVFLRSWVLSSLTTFLPFYLVQRG-YSLVFAGLLLSL--FLF 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 736322654 263 AGVQAGLISPFIA-RFGERRTIMTGLVASTLEFVVLSVARSAPVLYLSLVVGALGGLAQPAM 323
Cdd:cd17478 242 AGAIGTLIGGPLSdRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVT 303
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
16-390 |
4.76e-10 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 60.78 E-value: 4.76e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 16 LIDVMGIGLIIPVLPGLVKELAGSEAGGArFIGVLTAAYAAMQFIFApilGTLSDRFGRRPVLLLSLAGMVLDYLLLFFS 95
Cdd:cd17371 9 ALDGFDLLLLGLVLPALIAEFGLDEAEAG-LLGTVTLAGGAIGGILG---GILADRFGRVRVLVITILLFAVFTLLCGFA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 96 PNLWWLLVGRLIAGV-TGASLTVANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWL-----GEHGLRAPFLFAA 169
Cdd:cd17371 85 QNYWQLLILRALAGLgFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLfpllpPEIAWRVLFLLGA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 170 gLTALNFLYGLLVLPEslPPEKRGAAGGGTLNPFTPLRALTEYPLLRGLTLTFVLLG---LAGQVIVSTWV-LYTEGVLR 245
Cdd:cd17371 165 -LPALLVLFIRRFVKE--PPQWQAARAARRHFADRPSLRELFSPPLLRTTLLASLLAtgaLGGYYGITTWLpSYLTGERG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 246 WSplQNGIAFAVYGLLTAGVQAGLISPFIA-RFGERRTIMTGLVASTLEFVVLSVARSAP--VLYLSLVVGALGGLAQPA 322
Cdd:cd17371 242 LS--FEGSAGYLVVTILGGFLGYLAGGFLAdRIGRRNNFALFALGSAISILLYFFLPLSPtlILILGFPLGFFASGPFSG 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 736322654 323 MQGLISRQVGEQEQGRVMGAITSLNSLVGVFGPLLATSVFAAGqgaGFPGAAFVLGAVLSILGTVLIL 390
Cdd:cd17371 320 MGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSG---SLGTAIAVFAAVYYIAGLVLAL 384
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
7-192 |
6.31e-10 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 60.86 E-value: 6.31e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 7 ALLFILLTALIDVMGIGLIIPVLPGlvkELAGSEAGGARfigvLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMV 86
Cdd:TIGR00711 6 VLMLGTFMAVLDSTIVNVAIPTIAG---DLGSSLSQVQW----VITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 87 LDYLLLFFSPNLWWLLVGRLIAGVTGASLT-VANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLGEH-GLRAP 164
Cdd:TIGR00711 79 LGSLLCGVAPNLELMIIFRVIQGFGGGPLIpLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENyHWRWI 158
|
170 180
....*....|....*....|....*...
gi 736322654 165 FLFAAGLTALNFLYGLLVLPESLPPEKR 192
Cdd:TIGR00711 159 FLINVPIGIIVVVVAFFILPRDKPAASE 186
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
5-183 |
9.12e-10 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 59.92 E-value: 9.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 5 PPALLFILLTalidvMGIGLIIPVLPGLVKELAGSEAGgaRFIGVltaaYAAMQFIFAPILGTLSDRFGRRPVLLLSLAG 84
Cdd:cd17489 198 PPALILFLAS-----IAYGAISTFLPLYAAERGISNAG--LFFTV----YAIALLLSRPFSGKLSDRKGPKTVIIPGLLL 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 85 MVLDYLLLFFSPNLWWLLVGRLIAGVTGASLTVA-NAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLGEH-GLR 162
Cdd:cd17489 267 LALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPAlQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELfGYR 346
|
170 180
....*....|....*....|.
gi 736322654 163 APFLFAAGLTALNFLYGLLVL 183
Cdd:cd17489 347 AMFLLAAVVVLLALVLYIFLL 367
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
1-192 |
1.12e-09 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 59.54 E-value: 1.12e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 1 MPRRPPALLFILLTALIDV--MGIGLIIPVLPGLVKELAGSEAGGARFIGVLTAAYAAMQFIFapilGTLSDRFGRRPVL 78
Cdd:PRK11652 1 MKRQRNVNLLFMLVLLVAVgqMAQTIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFY----GPLSDRVGRRPVI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 79 LLSLAGMVLDYLLLFFSPNLWWLLVGRLIAGV-----------------TGASLTVANAYIadvtapedrakNFGRLgat 141
Cdd:PRK11652 77 LVGMSIFILGTLVALFAHSLTVLIAASAIQGLgtgvggvmartlprdlyEGTQLRHANSLL-----------NMGIL--- 142
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 736322654 142 wgVGFILGPMLGGWLGEH-GLRAPFLFAAGLTALNFLYGLLVLPESLPPEKR 192
Cdd:PRK11652 143 --VSPLLAPLIGGLLTTLfGWRACYLFLLLLGAGVTFSMARWMPETRPADAR 192
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
3-177 |
5.06e-09 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 57.59 E-value: 5.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 3 RRPPALLFILLTALIDvMGIGLIIPVLPGLVKELAGSEAggarFIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSL 82
Cdd:cd17335 196 RNPRVLAFLLVAFLMG-FGHGLIYSFLFWHLQDLGGSKT----LIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGL 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 83 AGMVLDYLLLFFSPNLWWLLVGRLIAGVT-GASLTVANAYIADVTAPEDRAKNFGRLGAT-WGVGFILGPMLGGWLGEH- 159
Cdd:cd17335 271 LAYVVRWLLYSFLENPWLVLPIELLHGLTfALVWAAAVSYASAAAPPGLRATAQGLLQGLyFGLGGGLGSLIGGYLYEAf 350
|
170
....*....|....*...
gi 736322654 160 GLRAPFLFAAGLTALNFL 177
Cdd:cd17335 351 GARTTFRFFAIAALAGLL 368
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
66-186 |
6.33e-09 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 57.19 E-value: 6.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 66 GTLSDRFGRRPVLLLSLAGMVLDYLLLFFSPNLWWLLVGRLIAGV-TGASLTVANAYIADVTAPEDRAK---------NF 135
Cdd:cd17359 57 GRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLaVGGASALVPMYIAEVAPAEIRGRlvslnqlmiVF 136
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 736322654 136 GRLGAtWGVGFILGPMLGG-WLGEHGLRAPFLFAAgLTALNFLYGLLVLPES 186
Cdd:cd17359 137 GQLLA-YIVNYLIANAGGAdWLGAEGWRWMLGLEA-IPAILFLLGMLFIPES 186
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
58-153 |
9.13e-09 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 56.43 E-value: 9.13e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 58 QFIFAPILGTLSDRFGRRPVLLLSLAGMVLDYLLLFFSPNLWWLLVGRLIAGVTGASLTVAN-AYIADVTAPEDRAKNFG 136
Cdd:cd17317 38 VLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGfVLGMEIVGPKYRSFVGI 117
|
90
....*....|....*..
gi 736322654 137 RLGATWGVGFILGPMLG 153
Cdd:cd17317 118 LFGLFWALGYMLLALLA 134
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
47-186 |
9.41e-09 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 56.90 E-value: 9.41e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 47 IGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVLDYLLLFFSP---NLWWLLVGRLIAGV-TGASLTVANAYI 122
Cdd:pfam00083 48 SGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVGIgVGGASVLAPMYI 127
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 736322654 123 ADVTAPEDRaknfGRLGATWGVGFILGPMLGGWLG--------EHGLRAPFLFAAGLTALNFLyGLLVLPES 186
Cdd:pfam00083 128 SEIAPKKLR----GALGSLYQLAITFGILLAYIFGlglnktsnSDGWRIPLGLQLVPALLLII-GLLFLPES 194
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
25-390 |
1.21e-08 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 56.40 E-value: 1.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 25 IIPVLPGLVKELAGSeaggARFIGVLTAAYAAMQFIFAPILGTLSDRFGRR-PVLLLSLAGMVLDYLLLFFSPNLWWLLV 103
Cdd:cd17370 18 ARSILPLFLVVLGAS----AAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRkPLVILGYGLSALAKPLLALAGSWQLVLL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 104 GRLIAGVTGASLTVA-NAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGG---WLGEHGLRAPFLFAAGLTALNFLYG 179
Cdd:cd17370 94 LRILERLGKGIRTPPrDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAAlllYLLGGNYRTIFLLAAIPALLALLIL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 180 LLVLPESLPPEKrgaagggtLNPFTPLRALTEYPLLRGLTLTFVLLGLAGQVIVSTWVLYTEGVLR---WSPLQNGIAFA 256
Cdd:cd17370 174 LFVVKEYPRPPK--------LRKKSKKTSLKKLPKAFWLYLLAVALFALGNFSFAFLILRAQELGLsaaLIPLLYALFNL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 257 VYGLltAGVQAGLISPfiaRFGERRTIMTGLVASTLEFVVLSVARSAPVLYLSLVVGALG-GLAQPAMQGLISRQVGEQE 335
Cdd:cd17370 246 VYAL--AAYPAGRLSD---RIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYmGAQESIERAAVADLVPAEL 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 736322654 336 QGRVMGAitsLNSLVGVFGpLLATSVFAAGQGAGFPGAAFVLGAVLSILGTVLIL 390
Cdd:cd17370 321 RGTAYGL---FNTVVGIGW-LLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
66-188 |
1.38e-08 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 56.04 E-value: 1.38e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 66 GTLSDRFGRRPVLLLSLAGMVLDYLLLFFSPNLWWLLVGRLIAGV-TGASLTVANAYIADVTAPEDRaknfGRLGATWGV 144
Cdd:cd17315 55 GPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLgVGLASVLVPLYISEIAPAKIR----GALGTLNQL 130
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 736322654 145 GFILGPMLGGWLG-------EHGLRAPFLFAAGLtALNFLYGLLVLPESLP 188
Cdd:cd17315 131 MITFGILLAYLLGlalslspPGWWRLMFALAAVP-ALLQLLLMFFLPESRA 180
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
49-203 |
1.51e-08 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 56.12 E-value: 1.51e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 49 VLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVLDYLLLFFSPNLWWLLVGRLIAG--VTGASLTVAnAYIADVT 126
Cdd:cd17360 39 LIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGlgVGIASMTVP-LYIAEAA 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 127 APEDRAK---------NFGRLGAtWGVGFILGPMLGGWLGEHGLrapflfaAGLTALNFLYGLLVLPES--LPPEKRGAA 195
Cdd:cd17360 118 PPRIRGRlvtinvlfiTGGQFVA-YVINGAFSYLPGGWRWMLGL-------AAVPAVLQFIGLLFLPESprWPSTRRALI 189
|
....*...
gi 736322654 196 GGGTLNPF 203
Cdd:cd17360 190 VGCGLQAF 197
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
47-353 |
1.73e-08 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 55.71 E-value: 1.73e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 47 IGVLTAAYAAMQFIFAPILGTLSDRFGRR-PVLLLSLAGMVLDYLLLFFSP---NLWWLLVGRLIA-GVTGASLTVANAy 121
Cdd:pfam12832 36 IGLITAILPLTRILAPPIWGWLADRTGKRkAVVRLASILAAVLFLSVLFIPislTFWWLALLVVLFsFFWNAILPQFEV- 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 122 iADVTAPEDRAKNFGRLgATWG-VGFILGPMLGGWLGEHgLRAPFLFAAGLTalnFLYGLLVLPESLPPEKRGAAGGGTL 200
Cdd:pfam12832 115 -ATLQHLGEKRKDYGRQ-RLWGsVGFALSVFGLGALFDH-YSVGLLPSVLFY---LFAALMLLSLLLPLAPPEMEYESKG 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 201 NPFTPLRALTEYPLLRGLTLTFVLLGLAGQVIVSTWVLYTEGvLRWSPLQNG--IAFAVYGLLTAGVQAGLIspfIARFG 278
Cdd:pfam12832 189 GSKAVFWNLLKQPEVIIFFLAAFLLGFSHGPFYTFLFLYLEN-LGASNTLLGalWALGVVAEIPLFFYAHRL---LRRFG 264
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 736322654 279 ERRTIMTGLVASTLEFVVLSVARSAPVLYLSLVV--GALGGLAQPAMQGLISRQVGEQEQGRVMGAITSLNSLVGVF 353
Cdd:pfam12832 265 HRNLLIIALLLTALRWLLYAFFVENPWLVLPIQFlhAISFGLTHAAAIEYVRRIFPGSLQGTGQALYSGLYFGLGGA 341
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
59-153 |
1.85e-08 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 56.18 E-value: 1.85e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 59 FIFAPILGTLSDRFGRRPVLLLSLAGMVLDYLLLFFSPNLWWLLVGRLIAGVTGASLTVaNAYI--ADVTAPEDRAKNFG 136
Cdd:TIGR00898 141 LLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWV-QAVVlnTEFLPKKQRAIVGT 219
|
90
....*....|....*..
gi 736322654 137 RLGATWGVGFILGPMLG 153
Cdd:TIGR00898 220 LIQVFFSLGLVLLPLVA 236
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
8-190 |
4.56e-08 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 54.50 E-value: 4.56e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 8 LLFILLTALIDVMGIGLIIPVLPGLVKElagseaggARFIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVL 87
Cdd:cd17384 2 LVIVYVALLLDNMLLTVVVPIIPDYLNE--------NVRVGLLFASKALVQLITNPIVGPLTNRIGYSLPMFVGFVIMFI 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 88 DYLLLFFSPNLWWLLVGRLIAGVTGASLTVAN-AYIADV-TAPEDRAKNFGRLGATWGVGFILGPMLGGWLGEH-GLRAP 164
Cdd:cd17384 74 STLLFAFGESYGVLFLARALQGVGSACSSVAGmGMLASLyPDDKERGKAMGIALGGLALGVLVGPPFGGVMYEFvGKSAP 153
|
170 180
....*....|....*....|....*.
gi 736322654 165 FLFAAGLTALNFLYGLLVLPESLPPE 190
Cdd:cd17384 154 FLILAFLALLDGALQLFILQPSVKSE 179
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
3-190 |
5.50e-08 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 54.54 E-value: 5.50e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 3 RRPPALLFILLTALIDVMGIGLIIPVLPGLVKELAGSEAGGARFIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSL 82
Cdd:PRK09874 216 KNPKLVLSLFVTTLIIQVATGSIAPILTLYVRELAGNVSNIAFISGMIASVPGVAALLSAPRLGKLGDRIGPEKILITAL 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 83 AGMVLDYLLLFFSPNLWWLLVGRLIAGVT-GASLTVANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWL-GEHG 160
Cdd:PRK09874 296 IFSVLLLIPMSFVQTPLQLGILRFLLGAAdGALLPAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVTGPLMGAAIsANYG 375
|
170 180 190
....*....|....*....|....*....|
gi 736322654 161 LRAPFLFAAGLTALNFLYGLLVLPESLPPE 190
Cdd:PRK09874 376 FRAVFLVTAGVVLFNAVYSWNSLRRRRIPQ 405
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
20-186 |
5.63e-08 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 54.50 E-value: 5.63e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 20 MGIGLIIPVLPGLVKELAG----SEAGGARFIGVLTAAYAAMQFIFAPILgtlsDRFGRRPVLLLSLAGMVLDYLLLFFS 95
Cdd:cd17358 16 IAVGWSSPALPSLMSDNSLslplTVAQFSWFGSLLTLGALIGALLSGKLA----DRIGRKRTLLISAIPCILGWLLIAFA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 96 PNLWWLLVGRLIAGVT-GASLTVANAYIADVTAPEDRaknfGRLGATWGVGFILGPMLGGWLGEH-GLRAPFLFAAGLTA 173
Cdd:cd17358 92 KDVWMLYLGRFLAGFGgGAASVVVPVYIAEIAPKNVR----GALGSLNQLLVNIGILLGYVLGSFlPWRTLALIGAIPPV 167
|
170
....*....|...
gi 736322654 174 LnFLYGLLVLPES 186
Cdd:cd17358 168 V-FLILLFFIPES 179
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
47-384 |
5.76e-08 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 54.25 E-value: 5.76e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 47 IGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVLDYLLLFFSPNLWWLLVGRLIAGV-TGASLTVANAYIADV 125
Cdd:cd17333 33 VSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLgAGILDTGANTFVGAL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 126 TaPEDRAKNFGRLGATWGVGFILGPMLGGWLGEHGLR--APFLFAAGLTALNFLYGLLVLPESLPPEKRGAAGGGTLNPF 203
Cdd:cd17333 113 F-EESSATRLNVLHGFFGLGALIGPLIATSLLTSELSwsWAYLIIGLIYLLLAILILLTLFPELPSARNPQQSVGAFSAS 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 204 TPLRALTEYPLLRGLtltFVLLGLAGQVIVSTWVlyTEGVLRWSPLQNGIAFAVYGLLTAGVQAG--LISPFIARFGERR 281
Cdd:cd17333 192 ASRLLRNPSIILGAL---ALFLYVGAETAFSSWV--PSYLVEKKHVSDGLAGYLLSGFWVGITIGrlLGGPISRRIKPHT 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 282 TIMTGLVASTLEFVVLSVARSAPVLYLSLVVGALGGLAQ-PAMQGLISRQVGeQEQGRVMGAITSLNSLVGVFGPLLATS 360
Cdd:cd17333 267 LLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALfPTILSLGISNLP-YAKGKGTSVLLAAGSIGGAIIPFIMGF 345
|
330 340
....*....|....*....|....
gi 736322654 361 VFAAGQGAGFPGAAFVLGAVLSIL 384
Cdd:cd17333 346 IAEAVGIQTAMLLITILYAIIFVL 369
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
47-357 |
1.24e-07 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 53.40 E-value: 1.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 47 IGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVLDYLLLFFSPNLWWLLVGRLIAGVTGASLTVA-NAYIADV 125
Cdd:cd17475 33 VGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGgGRAIMRW 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 126 TAPEDRAKNFGRLGATWGVGFILGPMLGGWLGEH-GLRAPFLFAAGLTALNFLYGLLVLPESLPPEkrgAAGGGTLNPFT 204
Cdd:cd17475 113 FPPRERGLAMGIRQTGVPLGGALAAALLPPLALHyGWRAAFVVAGLVSILAAVLFWLFYREPPAAS---AATESASTLLR 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 205 PLRALTEYPLLRGLTLTFVLLGLAGQVIVSTWVLYTEGVLRWSPLQNGIAFAVYGLLTAG--VQAGLISPFIaRFGERRT 282
Cdd:cd17475 190 SLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALgrIGLGRVSDRV-FGGRRRP 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 283 IMTGLVA-STLEFVVLSVARSAPVLYLSLVVGALGGLAQPAMQGL----ISRQVGEQEQGRVMGAITSLNSLVGVFGPLL 357
Cdd:cd17475 269 VLVITAAiAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLyltlVAESAGPEQAGTALGLANTINFIGIAIGPPL 348
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
3-181 |
2.36e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 52.23 E-value: 2.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 3 RRPPALLFILLTALIDVMGIGLIIPVLPGLVKELAGseaGGARFIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSL 82
Cdd:cd06173 205 RRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLG---GGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGA 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 83 AGMVLDYLLLFFSPNLWWLLVGRLIAGV-TGASLTVANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLGEH-G 160
Cdd:cd06173 282 LLLGLALLVLGLSPSLWLLLAALFLLGLaGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADAlG 361
|
170 180
....*....|....*....|.
gi 736322654 161 LRAPFLFAAGLTALNFLYGLL 181
Cdd:cd06173 362 LSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
48-316 |
4.09e-07 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 51.49 E-value: 4.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 48 GVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVLDYLLLFFSPNLWWLLVGRLIAGVTGASLTVA-NAYIADVT 126
Cdd:cd17393 37 GLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAANGALDVAmNAQGVAVE 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 127 APEDRAKnFGRLGATWGVGFILGPMLGGWLGehGLRAPFLFAAGLTALNFLYGLLVLPESLPPEKRGAAGGGTLNPFTPL 206
Cdd:cd17393 117 RAYGRPI-MSSLHAMWSLGGLAGALLGAAAI--GAGVSPGVHLLAAAVLLLLAALVAIRALLPGTGEAAEDRPDGAGKPG 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 207 RALTEyPLLRGLTLTFVLLGLAGQVIVSTWVLYTEGVLRWSPLQNGIAFAVY-GLLTAGVQAGliSPFIARFGERRTIMT 285
Cdd:cd17393 194 FLLPN-RLLLLLGLLALAAALAEGAAADWSALYLRDVLGASAALAALGYAVFsLAMTVGRLFG--DRLVDRFGDVAVLRA 270
|
250 260 270
....*....|....*....|....*....|.
gi 736322654 286 GLVASTLEFVVLSVARSAPVLYLSLVVGALG 316
Cdd:cd17393 271 GALLAALGLLLALLAPSVWVALAGFALMGLG 301
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
2-183 |
6.05e-07 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 51.15 E-value: 6.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 2 PRRPPALLFILLTALIDVMGIGLIIPV--LPGLVKELAGSEAGGARFIGVLTAAYAAMQFIFAPilgtLSDRFGRRPVLL 79
Cdd:cd06180 190 SAPGLNRPLWRLALAYGLFGFGYIITAtfLPLIARETGAGSLLAGLLWSLFGLAAVPSCFLWGA----LSDRWGTRRALA 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 80 LSLAGMVLDYLLLFFSPNLWWLLVGRLIAGVTGASLTVANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLGE- 158
Cdd:cd06180 266 ANLLVQAVGVLLPLLSPGPAGLVLSAVLFGGTFMAITALVMALARELAPPAAPRALALMTASFGVGQILGPLLAGWLADa 345
|
170 180
....*....|....*....|....*.
gi 736322654 159 -HGLRAPFLFAAGLTALNFLYGLLVL 183
Cdd:cd06180 346 tGGFAPALILAAAALVVAALLALLVL 371
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
54-392 |
7.17e-07 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 50.69 E-value: 7.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 54 YAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVLDYLLLFFSPNLWWLLVGRLIAGVTGASLtvanAYIADVTA-----P 128
Cdd:cd17353 47 TIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLGYGVLGGIGAGI----GYITPVSTavkwfP 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 129 EDRAKNFGRLGATWGVG-FILGPMLGGWLGEHGLRAPFL-FAAGLTALNFLYGLLVL--PESLPPEKRGAAGGGTLNP-- 202
Cdd:cd17353 123 DKRGLATGIVIAGFGLGsLIFSPLIAYLINTVGVPTTFLiLGIIFLIIIVIGAFLIRdpPKGWVPPGVDPLANNAENSpr 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 203 -FTPLRALTEyPLLRGLTLTFVLLGLAGQVIVSTWVLYTEGVLRWSPLQNGIAFAVYGLLTAG--VQAGLISPFIARfge 279
Cdd:cd17353 203 dYTPREMLRT-PTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGgrPFWGWLSDKIGR--- 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 280 RRTIMTGLVASTLEFVVLSVARSAPVLYLSLV--VGALGGLAQPAMQGLISRQVGEQEQGRVMGAITSLNSLVGVFGPLL 357
Cdd:cd17353 279 KNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGValIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPII 358
|
330 340 350
....*....|....*....|....*....|....*
gi 736322654 358 ATSVFAAGQGAgfpgAAFVLGAVLSILGTVLILSV 392
Cdd:cd17353 359 AAYVLYTGGYN----AAFIIAAALSLVALALALLL 389
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
47-185 |
8.14e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 50.64 E-value: 8.14e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 47 IGVLTAAYAAMQFIFAPILGTLSDRFGRR--PVLLLSLAGMVLDYLLLFFSPNLWWLLVGRLIAGV-TGASLTVANAYIA 123
Cdd:COG2271 218 AGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFgLGGAFGLLWALAA 297
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 736322654 124 DVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLGEH-GLRAPFLFAAGLTALNFLYGLLVLPE 185
Cdd:COG2271 298 ELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAtGYQAAFLLLAALALLAALLALLLLRE 360
|
|
| MFS_SLC46A3 |
cd17448 |
Solute carrier family 46 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
59-393 |
1.15e-06 |
|
Solute carrier family 46 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 3 (SLC46A3) is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. SLC46A3 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341006 Cd Length: 396 Bit Score: 50.11 E-value: 1.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 59 FIFAPILGTLSDRFGRRPVLLLSLAGMVLDYLLL----FFSPNLWWLLVGRLIAGVTGASLTVAN---AYIADVTApEDR 131
Cdd:cd17448 83 LIVTLILVSYSDRHGRKFSIILPSIGALLTSLSYclvsYFSFPLNLLIASSFISGLFGGFTTFIGgcfAYVADLCK-DHK 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 132 AKNFgRLGAtwgVGFILGpMLGG--------WLGEHGLRAPFLFAAGLTALNFLYGLLVLpeslppekrgaagggtlnpf 203
Cdd:cd17448 162 QKTI-RMAV---VDMILG-VLTGlaglssgyFIRALGFNWPFLTIALLHVVNLLYILFFL-------------------- 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 204 tplralteyPLLRGLTLTFVLLGLAGQVIVSTWVLYT-EGVLRWSP--LQNGIAFAVYGLLTAGVQAGLISPFIArfgER 280
Cdd:cd17448 217 ---------VVLCLLLFAFSTYLLANFGGASIFILYElNAPLCWNEvlVGYGSAASTAIFLTSFVGVALFSRCLP---DI 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 281 RTIMTGLVASTLEFVVLSVARSAPVLYLSLVVGALGGLAQPAMQGLISRQVGEQEQGRVMGAITSLNSLVGVFGPLLATS 360
Cdd:cd17448 285 YIVFIGIFSVAGGMIMTAFAKTTLLMFLVRLPLLFAIMPFPVLRSMMSKVVLPSEQGALFACVAFLETLSGVLSVTIFNS 364
|
330 340 350
....*....|....*....|....*....|...
gi 736322654 361 VFAAGQgAGFPGAAFVLGAVLSILGTVLILSVL 393
Cdd:cd17448 365 IYAATV-AWFPGFSFLLSAGLCLIPASLLCVLL 396
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
59-390 |
1.62e-06 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 49.93 E-value: 1.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 59 FIFAPILGTLSDR----FGRR-PVLLLSLAGMVLDYLLLFFSPNLWWLL--VGRLIAGVTGASLTV------------AN 119
Cdd:cd17313 48 LFVQPLVGSLSDRcnsrIGRRrPFILVGAPLAALGLILIPNAADIGLALgdGPRTWALVLFVLGIVlldfamnvcqgpVR 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 120 AYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLGEHG---------LRAPFLFAAGLTALNFLYGLLVLPE-SLPP 189
Cdd:cd17313 128 ALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAILWDHNwfgfalggnLKVPFYIGAIILLVCVLVTLFFVKEpPLSP 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 190 EKRGAAGGGTLNPFTP--LRALTEYPllRGLTLTFVLLGLAGQVIVSTWVLYT----EGVLR-----WSPLQNGIAFAVY 258
Cdd:cd17313 208 EAGEHSENPSLGEVLKslLKLLKIMP--RSLLRLLLVIFFWWIAFFPFELFFTdymgEEVYHgtsaaSSHYGAGVRMGAW 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 259 GL----LTAGVQAGLISPFIARFGERRTIMTGLVASTLEFVVLSVARSapvLYLSLVVGALGGLAQPAMQ----GLISRQ 330
Cdd:cd17313 286 GLlifsLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHN---VTVALVLFALGGIGWATINinpyPLVSDY 362
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 736322654 331 VGEQE--QGRVMGAITSLNSLVGVFGPLLATSVFaAGQGAgfpGAAFVLGAVLSILGTVLIL 390
Cdd:cd17313 363 HSESGrgQGTDTGLLNLAISLAQILVSLLAGPII-DVKGY---GTVFPVAAVASFLSLVGAL 420
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
5-174 |
1.90e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 49.49 E-value: 1.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 5 PPALLFILLTALIDVMGIGLIIPVLPGLVKELAGseaGGARFIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAG 84
Cdd:cd17473 196 WKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGG---GSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFAL 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 85 MVLDYLLLFFSPNLWWLLVGRLIAGV-TGASLTVANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLGE--HGL 161
Cdd:cd17473 273 MALGFLLLALASGLWVVLLGAILAGLgFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNltGGL 352
|
170
....*....|...
gi 736322654 162 RAPFLFAAGLTAL 174
Cdd:cd17473 353 SGAFLILGVLALV 365
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
51-384 |
2.56e-06 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 49.22 E-value: 2.56e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 51 TAAYAAMQFIFAPI----LGTLSDRFGRRPVLLLSLAGMVLDYLLLFFSPN-----LW---WLLVGRLIAGV-TGASLTV 117
Cdd:cd17367 42 TAAVFAVGFLMRPIggwlFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTyatigIWapiILLLARLLQGLsVGGEYGT 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 118 ANAYIADVTAPEDRAK---------NFGRLGATwGVGFILGPMLGG-WLGEHGLRAPFLFAAGLtALNFLYGLLVLPESL 187
Cdd:cd17367 122 SATYLSEVAPPGRRGFyssfqyvtlIGGQLLAL-GVLLVLQHTLGEdQMAAWGWRIPFLLGGVL-AVVVLWLRRGLEETE 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 188 PPEkrgAAGGGTLNPFTPLRALTEYPllRGLtLTFVLLGLAGQVIVSTWVLYTEGVLRWSP-LQNGIAFAVygLLTAGVQ 266
Cdd:cd17367 200 SFE---AIAESNEASAGTLRELRRHP--REL-LLVVGLTAGGTLAFYTWTTYLQKFLVNTAgFSKGDATWI--TTAALLV 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 267 AGLISPFIA----RFGERRTIM----TGLVASTLEFVVLSVARSAPVLYLSLVVGALGGLAQPAMQGLISRQVGEQEQgR 338
Cdd:cd17367 272 FMLLQPLGGrlsdRIGRRPLLLffgiGGTLATVPLLSALDHTDSPYTAFALVLVGLVFLSGYTSINAVVKAELFPTHV-R 350
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 736322654 339 VMGAITSLNSLVGVFG---PLLATSVFAAGQGAGFPGAAFVLGAVLSIL 384
Cdd:cd17367 351 ALGVGLPYALAVAIFGgtaPYVALWLKSIGHEWVFFWYVAGLIAISLVV 399
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
47-186 |
3.15e-06 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 48.79 E-value: 3.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 47 IGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVLDYLLLFFSPNLWW-LLVGRLIAGV-TGASLTVANAYIAD 124
Cdd:cd17356 47 QGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIIQVAAIGKWYqLIVGRIIAGLgVGFASVLVPVYQSE 126
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 125 VTAPEDRaknfGRLGATWGVGFILGPMLGGWL--GEHGLRAPFLFAAGLTaLNFLYGLLV------LPES 186
Cdd:cd17356 127 VAPKHIR----GTLVSLYQLAITIGILVAYCInyGTHKLDGSAQWRIPLG-LQIVWGLLLligmffLPES 191
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
49-389 |
4.16e-06 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 48.35 E-value: 4.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 49 VLTAAYAAMQfIFAPILGTLSDRFGRRPVLLLSLAGMVLDYLLLFFSPNLWWLLVGRLIAGV-TGASLTVANAYIADVTA 127
Cdd:cd17365 39 VGSAALFGMA-IGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLgLGAAMPNAITLVSEYAP 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 128 PEDRAKNFGRLGATWGVGFILGPMLGGWLGEH-GLRAPFLFAAGLTALNFlygllvlpeslppekrgaagggtlnpftpl 206
Cdd:cd17365 118 ARRRSLAVTLMFCGYPLGAALGGFLAAALIPAfGWRSVFLLGGVPPLILL------------------------------ 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 207 ralteyPLLRGlTLTFVLLGLAGQVIVSTWVLYTEGVLRWSPLQNGIAFAVYGLLTAGVQAG--LISPFIARFGERRTIM 284
Cdd:cd17365 168 ------PLLRG-TLLLWVTFFMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGslLLGWLADRFGPKRVLA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 285 TGLVASTLEFVVLSVARSAPVLYLSLV--VGALGGLAQPAMQGLISRQVGEQEQGRVMGAITSLNSLVGVFGPLLATSVF 362
Cdd:cd17365 241 LFFALGAVSLALLGVSPASLVLLYVLVflAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLL 320
|
330 340
....*....|....*....|....*..
gi 736322654 363 AAGQGAGFPGAAFVLGAVLSILGTVLI 389
Cdd:cd17365 321 AAGLGPESVFLALAIPAALGALAVLLL 347
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
269-399 |
7.72e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 47.54 E-value: 7.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 269 LISPFIARFGERRTIMTGLVASTLEFVVLSVARSAPVLYLSLVVGALG-GLAQPAMQGLISRqVGEQEQGRVMGAITSLN 347
Cdd:COG0738 62 PAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGlGLLDVAANPYVAA-LGPETAASRLNLLHAFF 140
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 736322654 348 SLVGVFGPLLATSVFAAGQGAGFPGAAFVLGAVLSILGTVLILSVLRGIPGT 399
Cdd:COG0738 141 SLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEE 192
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
47-390 |
9.45e-06 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 47.18 E-value: 9.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 47 IGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVLDYLLLFFSPNLWWLLVGRLIAGVTGASLTVANA-YIADV 125
Cdd:cd17319 40 YGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIkALAEW 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 126 TAPEDRAKNFGRLGATWGVGFILGPMLGGWL-GEHGLRAPFLFAAGLTALnflygLLVLpeslppekrgaagggtlnpft 204
Cdd:cd17319 120 FPARERGRATGLFNSGAPLGAAIGPPLSGWLlLLFGWRWAFIIEGLLGLL-----LAVL--------------------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 205 plrALTEYPLLRGLTLTFVLLGLAGQVIVSTWVLYTEGVLRWSPLQNGIAFAVYGLLT--AGVQAGLISPFIARFGERRT 282
Cdd:cd17319 174 ---WWFYLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGaiGMILGGRLSDRLLRGARRLV 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 283 IMTGLVASTLEFVVLSVARSAPVLYLSLVVGALG-GLAQPAMQGLISRQVGEQEQGRVMGAITSLNSLVGVFGPLLATSV 361
Cdd:cd17319 251 IIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGiGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYL 330
|
330 340
....*....|....*....|....*....
gi 736322654 362 FAAGQGagfPGAAFVLGAVLSILGTVLIL 390
Cdd:cd17319 331 VDATGS---YTAAFLFLAAVALLAALLVL 356
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
218-390 |
9.67e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 47.03 E-value: 9.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 218 LTLTFVLLGLAGQVIVSTWVLYTEGVLRWSPLQNGIAFAVYGLLTAGVQAgLISPFIARFGERRTIMTGLVASTLEFVVL 297
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQP-LAGRLSDRFGRRRVLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 298 SVARSAPVLYLSLVV-GALGGLAQPAMQGLISRQVGEQEQGRVMGAITSLNSLVGVFGPLLATSVFAAGQgagfPGAAFV 376
Cdd:pfam07690 80 LFASSLWLLLVLRVLqGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG----WRAAFL 155
|
170
....*....|....
gi 736322654 377 LGAVLSILGTVLIL 390
Cdd:pfam07690 156 ILAILSLLAAVLLL 169
|
|
| MFS_YxiO_like |
cd17482 |
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major ... |
37-169 |
1.04e-05 |
|
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis MFS-type transporter YxiO, and similar proteins including Listeria monocytogenes BtlA. The function of B. subtilis YxiO is still unknown, and L. monocytogenes BtlA is a putative secondary transporter involved in bile tolerance and general stress resistance. This family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341035 [Multi-domain] Cd Length: 362 Bit Score: 47.22 E-value: 1.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 37 AGSEAGGARFIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLS--LAGMVLDYLLLFFSPNLWWLLVGRLIAGVTGAS 114
Cdd:cd17482 31 GASPVTSTALWGYANSIASLVIALLAPILGAIADYSGRKKRFLAFfcLIGVVSTALLFFVTPGQWLLALLLFILANIGFS 110
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 736322654 115 LTVA--NAYIADVTAPEDRAKNFGRlGATWG-----------VGFILGPMLGGWLGEHGLRAPFLFAA 169
Cdd:cd17482 111 GANVfyDAFLPDVASPERMDRVSSL-GYALGyigggllfavnLVLILGPDAFGLDTAEAVRLSFLSVA 177
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
25-184 |
1.15e-05 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 47.01 E-value: 1.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 25 IIPVLPGLVKELAGSEAGGARFIgvltAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVLDYLLLFFSPNLWWLLVG 104
Cdd:PRK10091 22 IMGVLTELAHDVGISIPAAGHMI----SYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIGNAMFTLSSSYLMLAIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 105 RLIAGVTGASLTVANAYIADVTAPEDRAKN-FGRLGATWGVGFILGPMLGGWLGEH-GLRAPFLFAAGLTALNFLYGLLV 182
Cdd:PRK10091 98 RLVSGFPHGAFFGVGAIVLSKIIKPGKVTAaVAGMVSGMTVANLLGIPLGTYLSQEfSWRYTFLLIAVFNIAVLASIYFW 177
|
..
gi 736322654 183 LP 184
Cdd:PRK10091 178 VP 179
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
214-394 |
1.65e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 46.51 E-value: 1.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 214 LLRGLTLTFVLLGLAGQVIVSTWVLYTEGvLRWSPLQNGIAFAVYgLLTAGVQAGLISPFIARFGERRTIMTGLVASTLE 293
Cdd:COG2814 11 ALLALALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAY-LLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 294 FVVLSVARSAPVLYLS-LVVGALGGLAQPAMQGLISRQVGEQEQGRVMGAITSLNSLVGVFGPLLATSVFAAGQgagfPG 372
Cdd:COG2814 89 SLLCALAPSLWLLLAArFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG----WR 164
|
170 180
....*....|....*....|..
gi 736322654 373 AAFVLGAVLSILGTVLILSVLR 394
Cdd:COG2814 165 WVFLVNAVLALLALLLLLRLLP 186
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
7-186 |
1.85e-05 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 46.89 E-value: 1.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 7 ALLFILLTAL----IDVMGIGLiipVLPGLVKELAGSEAGGArFIGVLTaaYAAMqFIFAPILGTLSDRFGRRPVLLLSL 82
Cdd:TIGR01299 167 ALFFVLGLALmadgVEVFVVGF---VLPSAEKDLCIPDSGKG-MLGLIV--YLGM-MVGAFFWGGLADKLGRKQCLLICL 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 83 AGMVLDYLLLFFSPNLWWLLVGRLIAGV-TGASLTVANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLG-------G 154
Cdd:TIGR01299 240 SVNGFFAFFSSFVQGYGFFLFCRLLSGFgIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGGIYAAAMAwaiiphyG 319
|
170 180 190
....*....|....*....|....*....|....*....
gi 736322654 155 W---LGE----HGLRApFLFAAGLTALNFLYGLLVLPES 186
Cdd:TIGR01299 320 WsfqMGSayqfHSWRV-FVIVCAFPCVFAIGALTFMPES 357
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
44-186 |
2.04e-05 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 46.56 E-value: 2.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 44 ARFIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVLDYLLLF---FSPNLWWLLVGRLIAG--VTGASLTVA 118
Cdd:TIGR00879 70 SSLWGLVVSIFLVGGFIGALFAGWLSDRFGRKKSLLIIALLFVIGAILMGlaaFALSVEMLIVGRVLLGigVGIASALVP 149
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 736322654 119 nAYIADVTAPEDRAK--NFGRLGATWG--VGFILGPMLGGWLGEHGLRAPFLFAAGLTALNFLyGLLVLPES 186
Cdd:TIGR00879 150 -MYLSEIAPKALRGAltSLYQLAITFGilVAYGFGSGKVSLNNTLGWRIPLGLQLIPAGLLFL-GLFFLPES 219
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
247-394 |
2.46e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 46.03 E-value: 2.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 247 SPLQNGIAFAVYGLLTAGVQ--AGLISPfiaRFGERRTIMTGLVASTLEFVVLSVARSAPVLYLSLVV-GALGGLAQPAM 323
Cdd:cd17325 29 SVAQIGLIVAAYALAQLLFSppAGRLSD---RFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLqGLASAAVWPAA 105
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 736322654 324 QGLISRQVGEQEQGRVMGAITSLNSLVGVFGPLLATSVFAAGqgaGFPgAAFVLGAVLSILGTVLILSVLR 394
Cdd:cd17325 106 MALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL---GYR-APFLVCAALALLALVLALLLLP 172
|
|
| mfs |
NF037955 |
MFS transporter; |
21-388 |
2.70e-05 |
|
MFS transporter;
Pssm-ID: 411561 [Multi-domain] Cd Length: 366 Bit Score: 45.80 E-value: 2.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 21 GIGLIIPVLPGLVKELAGSeaggARFIGVLTAAYAAMQFIFAPILGTLSDR-FGRRPVLLLSLAGMVLDYLLLFFSPNLW 99
Cdd:NF037955 12 EIGIAMPFMPVWLEALGLD----AGVIGLLLALPIAVRIVATAPLMSLIDRgVGARRLLLAGSLGLALTYALMPAAAALG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 100 WLLVGRLIA--GVTGASLTVANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWL----GEHGLRAPFLFAAGLTA 173
Cdd:NF037955 88 WPLLALLVAlnAVAQAPLVPSIDYLTLAAVRRDPRLDYARIRMSGSVAFLAANLAGGALlgalGERVAVPLLLTGLALVA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 174 LNFLYGLLVLPESLPPEKRGAAgggtlnpftplraltEYPLLRGLTLtfvLLGLAGQVIVSTWVLYTEGVLRWSPLqnGI 253
Cdd:NF037955 168 ALVALASRVRAAAAPPRPREAG---------------RPRLPRVLWL---AIAAGAAIQASHAAIYAFGSIHWRAH--GI 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 254 AFAVYGLLTA-GVQA-----GLISPFIARFGE-RRTIMTGLVASTLEFVVLSVA--RSAPVLYLSLVVGALGGLAQPAMQ 324
Cdd:NF037955 228 STAWIGALWAiGVVAeivlfALLGRLPARWRTpFRLLGLGAAAALVRAIGMALLggTLAAVVPLQALHGLTFGATQLGAM 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 736322654 325 GLISRQVGEQEQGRVMGAITSLNSLVGVFGPLLATSVFAAGqgagfPGAAFVLGAVLSILGTVL 388
Cdd:NF037955 308 AAVSAFAPEGARGRAQGTYSAANALASASATLASGLAYRAG-----GPLAFALMAPLALIGLCL 366
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
59-112 |
4.15e-05 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 45.03 E-value: 4.15e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 736322654 59 FIFAPILGTLSDRFGRRPVLLLSLAGMVLDYLLLFFSPNLWWLLVGRLIAGVTG 112
Cdd:cd17379 47 LIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFG 100
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
6-181 |
5.27e-05 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 44.90 E-value: 5.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 6 PALLFILLTALIDVMGIGLIIPVLPGLVKELAGSeagGARFIGVLTAAYAAMQFIFAPIL-GTLSDRFGRRPVLLLSLAG 84
Cdd:cd17331 207 PGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGL---TPEENGYLMSYAGVLGMVVQGLLvGPLTKRFGERSLLKLSVAL 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 85 MVLDYLLLFFSPNLWWLLVGRLIAGVTGASL-TVANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWL-GEHGLR 162
Cdd:cd17331 284 LAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLyTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALlQAYGFP 363
|
170
....*....|....*....
gi 736322654 163 APFLFAAGLTALNFLYGLL 181
Cdd:cd17331 364 SFGLLGAAINGLLTVYLLL 382
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
44-390 |
5.38e-05 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 44.99 E-value: 5.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 44 ARFIGVLTAAYAAMQFIFAPILGTLSD----RFGR-RPVLLLSLAGMVLDYLLLFFSPNLW------WLLVGRLIAGVTG 112
Cdd:pfam13347 32 AAAVGLVLLVARLVDAFTDPIVGHIIDrtrtRWGRrRPWLLLSAIILAVSFILLFTPPELGraplfiWLLATYILLRIAY 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 113 ASLTVAN-AYIADVTA-PEDRAK---------NFGRLGATWGVGFILGPMLGGWLGEHGLRAPFLFAAGLTALNFLYGLL 181
Cdd:pfam13347 112 TFFEIPYwSLGPELTRdYDERTSltsyrsffsVGGGLLAAALAFPLVLILGGTGLERKGYRIFALIGAVLMLLGVIITAA 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 182 VLPESLPPEKRGAAGGGTLNPFTP-LRALTEYPLLRGLtLTFVLLGLAGQVIVSTWVLYtegVLRWSPLQNGIAFAVYGL 260
Cdd:pfam13347 192 GTKERVSMRSKEDTGQKEAGSLLDmLKEVFRNRAFLIL-LASFLLAALAMGVLNGLLLY---YFRYVLGNGFAASAFPLV 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 261 LTAGVQAG--LISPFIARFGERRTIMTGLV---ASTLEFVVLSVARSAPVLYLSLVVGALGGLAQPAMQGLISRQVGEQE 335
Cdd:pfam13347 268 FTIGALLGipLWPPLAKRIGKKNTYILGALitiAGFALALLLGPNNTLLFLVLYIIIGFGYGSSFFLPWSMLADVVDYGE 347
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 736322654 336 ---QGRVMGAITSLNSLV---------GVFGPLLATSVFAAGQGAGFPGAAFVLGAVLSILGTVLIL 390
Cdd:pfam13347 348 lrtGKRREGTFFAMWSFIsklatgvglGVSGLLLSAFGYNAGDSVQSPQAVTAIRLLYAVLPAVLFL 414
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
247-394 |
5.71e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 44.88 E-value: 5.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 247 SPLQNGIAFAVYGLLTAgvqagLISPFIA----RFGERRTIMTGLVASTLEFVVLSVARSAPVLYLSLVVGALGGLAQPA 322
Cdd:cd17330 32 SGYYVGLLQSSYSLGQF-----LASPLWGrlsdRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSV 106
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 736322654 323 MQGLISRQVGEQEQGRVMGAITSLNSLVGVFGPLLAtSVFAAGQGAGFPgaaFVLGAVLSILGTVLILSVLR 394
Cdd:cd17330 107 AQAYIADITDEEERAKAFGIISAAFGLGFILGPALG-GFLSTPYGYALP---FLVAAALALLNLVLVLFFLP 174
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
215-402 |
6.24e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 44.91 E-value: 6.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 215 LRGLTLTFVLLGLAGQVIVSTWVLYTEGVLRWSPLQNGIAFAVYGLltAGVQAGLISPFIA-RFGERRTIMTGLVASTLE 293
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAV--AGIVASLIGGRLAdRFGRKPVMLAGLLLRALG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 294 FVVLSVARSAPVLYLSLV-VGALGGLAQPAMQGLISRQVGEQEQGRVMGAITSLNSLVGVFGPLLATSVFAAGqgagfPG 372
Cdd:cd17329 79 FALLGFAHSPWLFAIALVlTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYS-----FR 153
|
170 180 190
....*....|....*....|....*....|
gi 736322654 373 AAFVLGAVLSILGTVLILSVLRGIPGTGRA 402
Cdd:cd17329 154 LLFLAAAVLFLLAALVLLFLLPETRPKRRA 183
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
252-402 |
6.96e-05 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 44.48 E-value: 6.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 252 GIAFAVYGLLTA------GVQAGLISPFIARFGERRTIMTGLVASTLEFVVLSVARSAPVLYLSLVVGALG-GLAQPAMQ 324
Cdd:COG2807 49 GLSATQAGLLTTlpllafGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGiAVGNVLLP 128
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 736322654 325 GLISRQVGEQeQGRVMGAITSLNSLVGVFGPLLATSVFAAgqgAGFPGAaFVLGAVLSILGTVLILSVLRGIPGTGRA 402
Cdd:COG2807 129 GLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAA---LGWRGA-LAVWALLALLALLLWLPLLRRRPAAAAA 201
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
6-131 |
7.75e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 44.49 E-value: 7.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 6 PALLFILLTALIDVMGIGLIIPVLPGLVKELAGSEAG-GARFIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAG 84
Cdd:cd17504 177 RNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTGFGlGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVI 256
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 736322654 85 MVLDYLLL-FFSPNLWWLLVGRLIAGVTGASLTVANAYIADVTAPEDR 131
Cdd:cd17504 257 SAVGLLLLaLLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDR 304
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
2-174 |
8.64e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 44.47 E-value: 8.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 2 PRRPPALLFILLTALI---DVMGIGLIIpVLPGLVKELAGSEAGGARFIGVLTAAYAAMQFIFapilGTLSDRFGRRPVL 78
Cdd:cd17478 189 TLKGVWRALLLLLIIVflrSWVLSSLTT-FLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIG----GPLSDRFGRRRVI 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 79 LLSLAGMVLDYLLLFFSPNLWWLLVGRLIAGVTGASLTVANAYIADVtAPEDRAKNFG-RLGATWGVGFILGPMLgGWLG 157
Cdd:cd17478 264 IASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQEL-LPGNVGLASGlMMGLSFGLGGIGAPVL-GALA 341
|
170
....*....|....*...
gi 736322654 158 EH-GLRAPFLFAAGLTAL 174
Cdd:cd17478 342 DAfGLESVLLILALLPLL 359
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
48-186 |
9.01e-05 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 44.56 E-value: 9.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 48 GVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVLDYLLLFFS---PNLWWLLVGRLIAGVTGASLTVANA-YIA 123
Cdd:cd17357 52 SLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSksaKSPELLIFGRFLVGIACGLSTGFVPmYLQ 131
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 124 DVTAPEDRaknfGRLGATWGVGFILGPMLGGWLG-------EHGLRApFLFAAGLTALNFLYGLLVLPES 186
Cdd:cd17357 132 EISPSELR----GALGSLTQIGVTLGILLGQVFGlpsvlgtETLWPY-LLFFPGIPALLQLAALPFFPES 196
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
9-181 |
1.02e-04 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 44.15 E-value: 1.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 9 LFILLTALIDVMGIGLIIPVLPGLVKELAGSEAggarfIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVLD 88
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVADLGPSSN-----STWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 89 YLLLFFSPNLWWLLVGRLIAGVTGASLTVANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLGEH---GLRAPF 165
Cdd:cd06179 76 SIVAGTAKSVNMLIGGQALIGIGAGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEAnaaGWRWIF 155
|
170
....*....|....*.
gi 736322654 166 LFAAGLTALNFLYGLL 181
Cdd:cd06179 156 YINAIFNALALILLFF 171
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
3-131 |
1.68e-04 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 43.38 E-value: 1.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 3 RRPPALLFILLTALIDVMGIGLIIPVLPGLVKEL---AGSEAG-----GARFIGVLTAAYAAMQFIFAPILGTLSDRFGR 74
Cdd:cd17313 231 IMPRSLLRLLLVIFFWWIAFFPFELFFTDYMGEEvyhGTSAASshygaGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGR 310
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 736322654 75 RPVLLLSLAGMVLDYLLLFFSPNLWWLLVGRLIAGVTGASL-TVANAYIADVTAPEDR 131
Cdd:cd17313 311 KKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATInINPYPLVSDYHSESGR 368
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
59-196 |
1.70e-04 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 43.60 E-value: 1.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 59 FIFAPILGTLSDRFGRRPVLLLSLAGMVLDYLLLFFSPNLWW-LLVGRLIAGVTGASLTVANAYIADVTAPEDRAKNFGR 137
Cdd:COG2270 288 ALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAfWILGLLIGLVMGGIQALSRSLLARLIPPGREAEFFGL 367
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 736322654 138 LGATWGVGFILGPMLGGWLGE--HGLRAPFLFAAGLtalnFLYGLLVLPESLPPEKRGAAG 196
Cdd:COG2270 368 YALSGKAASFLGPLLFGLVTQltGSQRLGILSLIVF----FVIGLVLLLRVKVPRGRAAAG 424
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
9-145 |
2.03e-04 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 43.37 E-value: 2.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 9 LFILLTAL----IDVMGIGLiipVLPGLVKELAGSEA-----GGARFIGVLTAAYaamqfifapILGTLSDRFGRRPVLL 79
Cdd:cd17438 1 FFVLGLALmadgVEVFVVGF---VLPSAEKDMCLSSSnkgmlGLIVYLGMMAGAF---------IWGGLADKLGRKRCLI 68
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 736322654 80 LSLAGMVLDYLLLFFSPNLWWLLVGRLIAGV-TGASLTVANAYIADVTAPEDRAKNFGRLGATWGVG 145
Cdd:cd17438 69 ISLAINASFAFLSSFVQGYGAFLFCRLISGFgIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIG 135
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
66-192 |
2.26e-04 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 42.96 E-value: 2.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 66 GTLSDRFGRRPVLLLSLAGMVLDYLLLFFSPNLWWLLVGRLI--AGVTGASLT----VANAYiadvtaPEDRAKN-FGRL 138
Cdd:PRK11043 62 GPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVqaVGVCSAAVIwqalVIDRY------PAQKANRvFATI 135
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 736322654 139 GATWGVGFILGPMLGGWLGEH-GLRAPFLFAAGLTALnflygLLVLPESLPPEKR 192
Cdd:PRK11043 136 MPLVALSPALAPLLGAWLLNHfGWQAIFATLFAITLL-----LILPTLRLKPSKK 185
|
|
| PRK10489 |
PRK10489 |
enterobactin transporter EntS; |
3-390 |
2.69e-04 |
|
enterobactin transporter EntS;
Pssm-ID: 236700 [Multi-domain] Cd Length: 417 Bit Score: 43.04 E-value: 2.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 3 RRPPALLFILLTALIDVMGIGLIIPVLPGLVKELAGSEAGgarfIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSL 82
Cdd:PRK10489 14 KTHPAFRAVFIARFISIFGLGLLGVAVPVQIQMMTGSTLQ----VGLSVTLTGGAMFIGLMVGGVLADRYDRKKLILLAR 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 83 AGMVLDYLLLFF-----SPNLWWLLVGRLIAGVTGASLTVANAYIADVTAPEDRAKNFGRLGA-TWGVGFILGPMLGGWL 156
Cdd:PRK10489 90 GTCGLGFIGLALnaflpEPSLLAIYLLGLWDGFFGSLGVTALLAATPALVGRENLMQAGAITMlTVRLGSVISPALGGLL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 157 -GEHGLRAPFLFAAGLTALNfLYGLLVLPESLPPEKrgaagggtlNPFTPLRALTE-------YPLLRGLTLTFVLLGLA 228
Cdd:PRK10489 170 iAAGGVAWNYGLAAAGTFIT-LLPLLRLPALPPPPQ---------PREHPLRSLLAgfrfllaSPVVGGIALLGGLLTMA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 229 GQVIVsTWVLYTEGVLRWSPLQNGIAF------AVYGLLTAGVQAGLISPFIARFGerrtimtGLVASTLEFVVLSVARS 302
Cdd:PRK10489 240 SAVRV-LYPALADEVWQMGAAQIGLLYaavplgAALGALTSGWLAHSARPGLLMLL-------STLGSFLAVGLFGLMPM 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 303 APVLYLSLVV-GALGGLAQPAMQGLISRQVGEQEQGRVMGAITSLNSLVGVFGPLLATsvfAAGQGAGFPGAAFVLGAVL 381
Cdd:PRK10489 312 WILAVLCLALfGYLSAISSLLQYTLLQTQTPDEMLGRINGLWTAQNVTGDAIGAALLG---GLGAMMTPVASASASGFGL 388
|
....*....
gi 736322654 382 SILGTVLIL 390
Cdd:PRK10489 389 LIIGVLLLL 397
|
|
| MFS_SLC18A3_VAChT |
cd17383 |
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ... |
9-183 |
2.86e-04 |
|
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340941 [Multi-domain] Cd Length: 378 Bit Score: 42.68 E-value: 2.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 9 LFILLTAL-IDVMGIGLIIPVLPGLVKELAGseaggarfIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVL 87
Cdd:cd17383 1 LVIVCIALlLDNMLYMVIVPIIPDYLNEDIA--------IGVLFASKAIVQLLVNPFSGTLIDRVGYDIPMMIGLTVMFL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 88 DYLLLFFSPNLWWLLVGRLIAGVTGA-SLTVANAYIAD-VTAPEDRAKNFGRLGATWGVGFILGPMLGGWLGEH-GLRAP 164
Cdd:cd17383 73 STAVFAFGESYAVLFFARSLQGVGSAfADTAGLAMIADrFTEEAERSKALGIALAFISFGCLVAPPFGGILYEFaGKEVP 152
|
170
....*....|....*....
gi 736322654 165 FLFaagLTALNFLYGLLVL 183
Cdd:cd17383 153 FLI---LAFVCLLDGLLLL 168
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
60-390 |
3.05e-04 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 42.59 E-value: 3.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 60 IFAPILGTLSDRF-----GRRPVLLLSLAGMVLDYLLLFFSPN------LWWLLVGRLIAGVTGASLTVA-NAYIADVTA 127
Cdd:cd17332 50 INDPLMGYLIDRTrsrwgRFRPWLLWGAIPLALLFVLLFTTPDgsgtgkLIYALITYILLDLLYTLVNIPyTALIPELTD 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 128 -PEDRAK-----NFGRLGATWGVGFILGPMLGGWLGEHGLRAPFLFAAGLTALNFLYGLLVLPESLPPEKRGAAGGGTLN 201
Cdd:cd17332 130 dPEERTSltswrMFFATIGGLLVTVLPPPLVAYFGGGNASRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSKLP 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 202 PFTPLRALTEYPLLRGLTLTFVLLGLAGQVIVSTWVLYTEGVLrwSPLQNGIAFAVYGLLTAGVQAGLISPFIARFGERR 281
Cdd:cd17332 210 LLKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVL--GGRAELVLLLLLILSGALLALLPWPPLKKRFGKKK 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 282 TIMTGLVASTLEFVVLSVArSAPVLYLSLVVGALGGLAQPAMQGLISRQV------GEQEQG-RVMGAITSLNSLVGVFG 354
Cdd:cd17332 288 AFFIGLLLAILGLLLLFFL-PPGNLVLILVLAVLAGIGYGGANLLPWAMLadvidyGELKTGkRREGIFYSVMTFFRKLG 366
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 736322654 355 plLATSVFAAGQGAGFPG------------------AAFVLGAVLSILGTVLIL 390
Cdd:cd17332 367 --LALAGALVGLILSLAGyvanaaaqsasalngirlLIAVLPAVLLLLALILMS 418
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
28-186 |
3.11e-04 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 42.86 E-value: 3.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 28 VLPGLVKELAGSEAGGArFIGVLTaaYAAMqFIFAPILGTLSDRFGRRPVLLLSLAGMVLDYLLLFFSPNLWWLLVGRLI 107
Cdd:cd17363 21 VLPSAEKDMCLSNSNKG-MLGLIV--YLGM-MVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYGFFLFCRLL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 108 AGV-TGASLTVANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLG-------GW---LGE----HGLRApFLFAAGLT 172
Cdd:cd17363 97 SGIgIGGSIPIVFSYFAEFLAREKRGEHLSWLCMFWMIGGLYASAMAwaiiphyGWgfsMGTayqfHSWRV-FVIVCALP 175
|
170
....*....|....
gi 736322654 173 ALNFLYGLLVLPES 186
Cdd:cd17363 176 SVASVVALTFMPES 189
|
|
| MFS_MFSD6L |
cd17479 |
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the ... |
12-154 |
3.72e-04 |
|
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the Major Facilitator Superfamily; Major facilitator superfamily domain-containing protein 6-like (MFSD6L) protein family includes a group uncharacterized proteins similar to human major facilitator superfamily domain-containing protein 6 (MFSD6). MFSD6 is also called Macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. The MFSD6L family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341032 [Multi-domain] Cd Length: 376 Bit Score: 42.30 E-value: 3.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 12 LLTALIDVMGIGLIIPVLPGLVKELAGSEAggarFIGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVLDYLL 91
Cdd:cd17479 209 ALTVFLVGFVGSTVQNFLFWLMQDKGGSEL----HMGLSIALALLSEILMSFFGNWLLRKLGHAGCVVLGLLGLGAQLLY 284
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 736322654 92 LFFSPNLWWLLVGRLIAGVTGASLTVA-NAYIADVTAPE-DRAKNFGRLGATWGVGFILGPMLGG 154
Cdd:cd17479 285 YSFLWTPWAVLPIELLHAFSNGALWWAvNSQVEFLASPGmERSLQLVLRALYYGIGFALGSFVSG 349
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
246-402 |
3.92e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 42.26 E-value: 3.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 246 WSPLQNGIAFAVyGLLTAGVQAGLISPFIARFGERRTIMTGLVASTLEFVVLSVARSAPVLYLS---LVVGALGGLAQPA 322
Cdd:cd17355 35 WSRAVISLAFTV-GLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLwglLGGGGAGTLAAVA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 323 MQGLISRQVGEQeQGRVMGAITSLNSLVGVFGPLLATSVFAAgqgAGFPGAAFVLGAVLSILGTVLILSVLRGIPGTGRA 402
Cdd:cd17355 114 FATVAAWWFERR-RGLALGILTAGGGLGSLVFLPLGAALIEA---FGWRTALLVLALLALLVLVPVLLLLRRRPADLALR 189
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
58-148 |
4.09e-04 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 42.28 E-value: 4.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 58 QFIF-------APILGTLSDRFGRRPVLLLSLAGMVLDYLLLFFSPNLWWLLVGRLIAGVTGASLTVAN-AYIADVTAPE 129
Cdd:cd17374 41 QSIFmagllvgALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTlILGTEWTTPR 120
|
90
....*....|....*....
gi 736322654 130 DRAKNFGRLGATWGVGFIL 148
Cdd:cd17374 121 HRALAITLTSCFFSIGQML 139
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
20-192 |
5.59e-04 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 41.82 E-value: 5.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 20 MGIGLIIPVLPGLVKELaGSEAGGARF-IGVLTAAYAAMQFIFAPilgtLSDRFGRRPVLLLSLAGMVLDYLLLFFSPNL 98
Cdd:PRK11102 5 LAIDMYLPALPVIAADF-GVSAGSVQMtLSAYILGFAIGQLFYGP----MADSFGRKPVILGGTLVFALAAVACALAQTI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 99 WWLLVGRLIAGVTGASLTVA-NAYIADVTAPED--RAKNFGRLGATwgVGFILGPMLGGWLGE-HGLRAPFLFAAGLTAL 174
Cdd:PRK11102 80 DQLIYMRFLHGLAAAAASVViNALMRDMFPKEEfsRMMSFVTLVMT--IAPLLAPIIGGWLLVwFSWHAIFWVLALAAIL 157
|
170
....*....|....*...
gi 736322654 175 NFLYGLLVLPESLPPEKR 192
Cdd:PRK11102 158 AAALVFFFIPETLPKERR 175
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
66-186 |
6.21e-04 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 41.57 E-value: 6.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 66 GTLSDRFGRRPVLLLSLAGMVLDYLLLFFSPNLWWLLVGRLIAGV-TGASLTVANAYIADVTAPEDRA------KNFGRL 138
Cdd:cd17362 60 GALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVgIGLAMHAAPVYIAETSPSHIRGllvslkELFIVL 139
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 736322654 139 GATWG--VGFILGPMLGGWLGEHGLRAPFLFAAGLtalnflyGLLVLPES 186
Cdd:cd17362 140 GILLGyvSGYAFADVVGGWRYMYGLAAPPALLLGI-------GMWFLPPS 182
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
11-155 |
1.02e-03 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 40.86 E-value: 1.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 11 ILLTALIDVMGIGLIIPVLPG-LVKELAGSEAGgarFIGVLTAAYAAMQFIFAPILGTLSDRFGRR----PVLLLSLAGM 85
Cdd:cd17314 210 ILFIAIFLVLIGGFLFIANMAsLVRSLQLDAPS---FVTKLMSIYGLFNAFGRLLWGIVADFFGGRlstlSILLTILGLG 286
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 86 VLDYLLLFFSPNLWWLLVGRLIAGVTGASLTVANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGW 155
Cdd:cd17314 287 LCAFLFLLKMTPVGLVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAK 356
|
|
| PRK11646 |
PRK11646 |
multidrug efflux MFS transporter MdtH; |
244-359 |
1.50e-03 |
|
multidrug efflux MFS transporter MdtH;
Pssm-ID: 183255 Cd Length: 400 Bit Score: 40.43 E-value: 1.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 244 LRWSPLQNGIAFAVYGLLTAGVqaGLISPFIA-RFGERRTIMTGLVASTLEFVVLSVARSAPVLYLSLVVGALGG-LAQP 321
Cdd:PRK11646 41 LGWAAVMVGIALGLRQFIQQGL--GIFGGAIAdRFGAKPMIVTGMLMRAAGFATMAIAHEPWLLWLSCILSGLGGtLFDP 118
|
90 100 110
....*....|....*....|....*....|....*...
gi 736322654 322 AMQGLISRQVGEQEQGRVMGAITSLNSLVGVFGPLLAT 359
Cdd:PRK11646 119 PRTALVIKLIRPHQRGRFFSLLMMQDSAGAVIGALLGS 156
|
|
| MFS_YdiM_like |
cd17396 |
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ... |
63-115 |
1.53e-03 |
|
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340954 [Multi-domain] Cd Length: 384 Bit Score: 40.41 E-value: 1.53e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 736322654 63 PILGTLSDRFGRRPVLLLSLAGMVLDYLLLFFSPNLWWLLVGRLIAGVTGASL 115
Cdd:cd17396 53 LFAGVLSDKFGRKPSVLLGMVLYALFFVGILFSPNLIIAYVFALLAGAANSFL 105
|
|
| MFS_GLUT12_Class3 |
cd17435 |
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
66-187 |
1.67e-03 |
|
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340993 [Multi-domain] Cd Length: 376 Bit Score: 40.17 E-value: 1.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 66 GTLSDRFGRRPVLLLSLAGMVLDYLLLFFSPNLWWLLVGRLIAGVTGA-SLTVANAYIADVtAPEDRAknfGRLGATWGV 144
Cdd:cd17435 57 GVLIDRYGRRTAIILTSCLLVLGSLLLVCSVSYTVLIVGRIAIGVSISlSSIATCVYIAEI-APQHRR---GLLVSLNEL 132
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 736322654 145 GFILGPMLGGWLGehglrapFLFAAGLTALNFLYGLLVLPESL 187
Cdd:cd17435 133 MIVIGILLAYISN-------YAFANVSNGWKYMFGLVIPLAAL 168
|
|
| MFS_MFSD5_like |
cd17487 |
Major facilitator superfamily domain containing 5 protein; Human major facilitator superfamily ... |
47-110 |
2.18e-03 |
|
Major facilitator superfamily domain containing 5 protein; Human major facilitator superfamily domain containing 5 protein (MFSD5) is also called molybdate-anion transporter, or molybdate transporter 2 homolog (MOT2). It acts as an atypical solute carrier (SLC) that mediates high-affinity intracellular uptake of the rare oligo-element molybdenum. It may also play a role in maintaining the glucose homeostasis and pancreatic beta-cell proliferation, as well as in altered energy homeostasis. MFSD5 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341040 Cd Length: 385 Bit Score: 39.89 E-value: 2.18e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 736322654 47 IGVLTAAYAAMQFIFAPILGTLSDRFGRRP-----VLLLSLAgmvldyLLLFFSPNLWWLLVGRLIAGV 110
Cdd:cd17487 40 IAILFVTGFGSSVVFGTFVGSLADKFGRKRacllfCVLYSLS------CLTKHSPNFGVLLLGRVLGGI 102
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
47-186 |
2.40e-03 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 39.69 E-value: 2.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 47 IGVLTAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVLDYLLLFFSPNLWWLLVGRLIAGV-TGASLTVANAYIADV 125
Cdd:cd17437 34 EEVLIGSLNIISLVGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYPVLMVGRFVAGIgVGFALMIAPVYTAEV 113
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 736322654 126 TAPEDRA--KNFGRLGATWGV--GFILGPMLGGWLGEHGLRApFLFAAGLTALNFLYGLLVLPES 186
Cdd:cd17437 114 APASSRGflTSFPEIFINIGIllGYVSNYAFSGLPLHVGWRL-MLGVGAVPSLFLAIGVLAMPES 177
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
8-156 |
2.53e-03 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 39.65 E-value: 2.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 8 LLFILLTALIDVMGIGLIIpVLPGLVKELAGSEAGGARFIGVLTAAYAAMQFIFapilGTLSDRFGRRPVLLLSLAGMVL 87
Cdd:TIGR00895 253 VLLWLLYFMLLVGVYFLTN-WLPKLMVELGFSLSLAATGGALFNFGGVIGSIIF----GWLADRLGPRVTALLLLLGAVF 327
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 736322654 88 DYLL--LFFSPNLWwLLVGRLIAGVTGASLTVANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWL 156
Cdd:TIGR00895 328 AVLVgsTLFSPTLL-LLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYL 397
|
|
| MFS_SLC22A6_OAT1_like |
cd17446 |
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ... |
54-116 |
2.54e-03 |
|
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 39.71 E-value: 2.54e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 736322654 54 YAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVLDYLLLFFSPNLWWLLVGRLIAGVTGASLT 116
Cdd:cd17446 42 YMAGVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMALSGIV 104
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
11-189 |
3.22e-03 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 39.17 E-value: 3.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 11 ILLTALIDVMGIGLIIPVLPGLVKELAGSEAGGARFIgvltAAYAAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVLDYL 90
Cdd:cd17476 3 ISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLA----ASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 91 LLFFSPNLWWLLVGRLIAGVtGASLTVANAY-IADVTAPEDRAKN--FGRLGATWGVGFILGPMLGGWLGEH-GLRAPFL 166
Cdd:cd17476 79 IAGFSPNFIFFIICRALQGL-GPAFLLPNAMaLLGRTYPPGPRKNivFSLFGATAPLGFALGGVFGGLFAQLaWWPWIFW 157
|
170 180
....*....|....*....|...
gi 736322654 167 FAAGLTALNFLYGLLVLPESLPP 189
Cdd:cd17476 158 FLAILAAIVAVAAIFWTSPSFIA 180
|
|
| MFS_SLC22A4_5_OCTN1_2 |
cd17376 |
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ... |
46-151 |
3.37e-03 |
|
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340934 [Multi-domain] Cd Length: 342 Bit Score: 39.37 E-value: 3.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 46 FIGVLTAAYaamqfifapILGTLSDRFGRRPVLLLSLAGMVLDYLLLFFSPNLWWLLVGRLIAGVTGASLTVAnAYI--A 123
Cdd:cd17376 45 FVGVLLGSF---------ISGQLSDRFGRKKVLFATMAVQTGFSFLQIFSPSWEMFTVLFVIVGMGQISNYVV-AFVlgT 114
|
90 100 110
....*....|....*....|....*....|
gi 736322654 124 DVTAPEDRAKnFGRLGAT--WGVGFILGPM 151
Cdd:cd17376 115 EILGKSVRIL-FSTLGVCifYAIGYMLLPL 143
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
10-147 |
3.49e-03 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 39.63 E-value: 3.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 10 FILLTALI-DVMGIGLIIPVLPGLVKELAGSEA-----GGARFIGVLTAAYaamqfifapILGTLSDRFGRRPVLLLSLA 83
Cdd:cd17439 2 FVLGLALMaDGVEVFVVGFVLPSAEKDMCLSDSnkgmlGLIVYLGMMVGAF---------LWGGLADRIGRRQCLLISLS 72
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 736322654 84 gmvLDYLLLFFSP---NLWWLLVGRLIAGV-TGASLTVANAYIADVTAPEDRAKNFGRLGATWGVGFI 147
Cdd:cd17439 73 ---VNSVFAFFSSfvqGYGTFLFCRLLSGVgIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGI 137
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
55-129 |
4.62e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 39.05 E-value: 4.62e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 736322654 55 AAMQFIFAPILGTLSDRFGRRPVLLLSLAGMVLDYLLLFfspnlwWLLVGRLIAGVTGASLTVANAYIADVTAPE 129
Cdd:cd17369 274 SVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFF------WLLDTGSTWLIVLAAVVVLGVLHGMMYGPQ 342
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
276-402 |
7.34e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 38.37 E-value: 7.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 276 RFGERRTIMTGLVASTLEFVVLSVARSAPVLYLSLV-VGALGGLAQPAMQGLISRQVGEQEQGRVMG----AITSLNSLV 350
Cdd:cd17475 57 RFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFlVGAGYGSVQPGGGRAIMRWFPPRERGLAMGirqtGVPLGGALA 136
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 736322654 351 GVFGPLLATsvfaagqGAGFPgAAFVLGAVLSILGTVLILSVLRGIPGTGRA 402
Cdd:cd17475 137 AALLPPLAL-------HYGWR-AAFVVAGLVSILAAVLFWLFYREPPAASAA 180
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
64-284 |
7.99e-03 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 38.14 E-value: 7.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 64 ILGTLSDRFGRRPVLLLSLAGMVLDYLLLFFSPNLWWLLVGRLI-----AGVTGASLTvanaYIADVTAPEDRAKNFGRL 138
Cdd:PRK03893 74 LLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVigmgmAGEYGSSAT----YVIESWPKHLRNKASGFL 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736322654 139 GATWGVGFILGPMLGGWLGE-HGLRApfLFAAGLTALNF-LYGLLVLPESLPPEKRGAAGGGTLNPFTPLRALTEYPLLR 216
Cdd:PRK03893 150 ISGFSIGAVVAAQVYSLVVPvWGWRA--LFFIGILPIIFaLWLRKNLPEAEDWKEKHAGKAPVRTMVDILYRGEHRIINI 227
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 736322654 217 GLTLTfvllglagqVIVSTWVLYTEGVlrwsplQNGIAFAVYGLLTAgvqAGLISpFIARFGERRTIM 284
Cdd:PRK03893 228 LLTLA---------AAAALWFCFAGNL------QNAAIVAVLGLLCA---AIFIS-FMVQSSGKRWPT 276
|
|
| |
