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Conserved domains on  [gi|730239186|ref|WP_033943667|]
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MULTISPECIES: Mu transposase C-terminal domain-containing protein, partial [Pseudomonadota]

Protein Classification

transposase( domain architecture ID 10415557)

transposase binds to the end of a transposon and catalyzes the movement of the transposon to another part of the genome by a cut and paste mechanism or a replicative transposition mechanism

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Mu-transpos_C pfam09299
Mu transposase, C-terminal; Members of this family are found in various prokaryotic integrases ...
 329-392 1.65e-09

Mu transposase, C-terminal; Members of this family are found in various prokaryotic integrases and transposases. They adopt a beta-barrel structure with Greek-key topology.


:

Pssm-ID: 430512  Cd Length: 61  Bit Score: 53.31  E-value: 1.65e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 730239186  329 LDFADIEDRTIERYGMRWDNIEYWDEVLRPFLDageqRKFVVRRNPYDASRIYFLHPiEGTY-CE 392
Cdd:pfam09299   2 LLLLPRETRTVQRDGIRLFGNRYWSPELAGYVG----EKVVVRYDPRDLSRIYVYDL-DGRFiCE 61
rve super family cl47583
Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into ...
 104-221 1.19e-03

Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.


The actual alignment was detected with superfamily member pfam00665:

Pssm-ID: 459897 [Multi-domain]  Cd Length: 98  Bit Score: 38.06  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730239186  104 PLERIQIDHTLVDVvcasaFDREhvGRPWITIALDECTRAVLAFVLTWEyPNASTVAQCMTRVmtpkdewLERVGvplpw 183
Cdd:pfam00665   1 PNQLWQGDFTYIRI-----PGGG--GKLYLLVIVDDFSREILAWALSSE-MDAELVLDALERA-------IAFRG----- 60

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 730239186  184 pmyGTPNSVYLDNAAEFWSRALFYGCREYGIAPPEHRP 221
Cdd:pfam00665  61 ---GVPLIIHSDNGSEYTSKAFREFLKDLGIKPSFSRP 95
 
Name Accession Description Interval E-value
Mu-transpos_C pfam09299
Mu transposase, C-terminal; Members of this family are found in various prokaryotic integrases ...
 329-392 1.65e-09

Mu transposase, C-terminal; Members of this family are found in various prokaryotic integrases and transposases. They adopt a beta-barrel structure with Greek-key topology.


Pssm-ID: 430512  Cd Length: 61  Bit Score: 53.31  E-value: 1.65e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 730239186  329 LDFADIEDRTIERYGMRWDNIEYWDEVLRPFLDageqRKFVVRRNPYDASRIYFLHPiEGTY-CE 392
Cdd:pfam09299   2 LLLLPRETRTVQRDGIRLFGNRYWSPELAGYVG----EKVVVRYDPRDLSRIYVYDL-DGRFiCE 61
rve pfam00665
Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into ...
 104-221 1.19e-03

Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.


Pssm-ID: 459897 [Multi-domain]  Cd Length: 98  Bit Score: 38.06  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730239186  104 PLERIQIDHTLVDVvcasaFDREhvGRPWITIALDECTRAVLAFVLTWEyPNASTVAQCMTRVmtpkdewLERVGvplpw 183
Cdd:pfam00665   1 PNQLWQGDFTYIRI-----PGGG--GKLYLLVIVDDFSREILAWALSSE-MDAELVLDALERA-------IAFRG----- 60

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 730239186  184 pmyGTPNSVYLDNAAEFWSRALFYGCREYGIAPPEHRP 221
Cdd:pfam00665  61 ---GVPLIIHSDNGSEYTSKAFREFLKDLGIKPSFSRP 95
 
Name Accession Description Interval E-value
Mu-transpos_C pfam09299
Mu transposase, C-terminal; Members of this family are found in various prokaryotic integrases ...
 329-392 1.65e-09

Mu transposase, C-terminal; Members of this family are found in various prokaryotic integrases and transposases. They adopt a beta-barrel structure with Greek-key topology.


Pssm-ID: 430512  Cd Length: 61  Bit Score: 53.31  E-value: 1.65e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 730239186  329 LDFADIEDRTIERYGMRWDNIEYWDEVLRPFLDageqRKFVVRRNPYDASRIYFLHPiEGTY-CE 392
Cdd:pfam09299   2 LLLLPRETRTVQRDGIRLFGNRYWSPELAGYVG----EKVVVRYDPRDLSRIYVYDL-DGRFiCE 61
rve pfam00665
Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into ...
 104-221 1.19e-03

Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.


Pssm-ID: 459897 [Multi-domain]  Cd Length: 98  Bit Score: 38.06  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 730239186  104 PLERIQIDHTLVDVvcasaFDREhvGRPWITIALDECTRAVLAFVLTWEyPNASTVAQCMTRVmtpkdewLERVGvplpw 183
Cdd:pfam00665   1 PNQLWQGDFTYIRI-----PGGG--GKLYLLVIVDDFSREILAWALSSE-MDAELVLDALERA-------IAFRG----- 60

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 730239186  184 pmyGTPNSVYLDNAAEFWSRALFYGCREYGIAPPEHRP 221
Cdd:pfam00665  61 ---GVPLIIHSDNGSEYTSKAFREFLKDLGIKPSFSRP 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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