NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|652967171|ref|WP_027220144|]
View 

MULTISPECIES: GNAT family N-acetyltransferase [Legionella]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10006981)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
43-157 1.12e-10

Predicted N-acetyltransferase YhbS [General function prediction only];


:

Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 56.25  E-value: 1.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652967171  43 GVEYREGVMHTLRRDLYIGTY-----AGQPVAMFALLEHEFPNSRGlsARELMYVYVDKNYRGLGFGKQIIEEAKRLATA 117
Cdd:COG3153   21 GPGREAELVDRLREDPAAGLSlvaedDGEIVGHVALSPVDIDGEGP--ALLLGPLAVDPEYRGQGIGRALMRAALEAARE 98

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 652967171 118 VGSDLILLDTlKPSLNRLYEKHGAKVVCEGSLFSHPTDVL 157
Cdd:COG3153   99 RGARAVVLLG-DPSLLPFYERFGFRPAGELGLTLGPDEVF 137
 
Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
43-157 1.12e-10

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 56.25  E-value: 1.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652967171  43 GVEYREGVMHTLRRDLYIGTY-----AGQPVAMFALLEHEFPNSRGlsARELMYVYVDKNYRGLGFGKQIIEEAKRLATA 117
Cdd:COG3153   21 GPGREAELVDRLREDPAAGLSlvaedDGEIVGHVALSPVDIDGEGP--ALLLGPLAVDPEYRGQGIGRALMRAALEAARE 98

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 652967171 118 VGSDLILLDTlKPSLNRLYEKHGAKVVCEGSLFSHPTDVL 157
Cdd:COG3153   99 RGARAVVLLG-DPSLLPFYERFGFRPAGELGLTLGPDEVF 137
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 55-140 1.18e-08

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 49.38  E-value: 1.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652967171   55 RRDLYIGTYAGQPVAMFALLEHEfpnsrGLSARELMYVYVDKNYRGLGFGKQIIEEAKRLATAVGSDLILLDTLKPSLnR 134
Cdd:pfam13508   2 GGRFFVAEDDGKIVGFAALLPLD-----DEGALAELRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELETTNRAA-A 75


                  ....*.
gi 652967171  135 LYEKHG 140
Cdd:pfam13508  76 FYEKLG 81
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 58-126 6.47e-06

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 41.88  E-value: 6.47e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 652967171  58 LYIGTYAGQPVAMFALLEHEFPNSRGlsarELMYVYVDKNYRGLGFGKQIIEEAKRLATAVGSDLILLD 126
Cdd:cd04301    1 FLVAEDDGEIVGFASLSPDGSGGDTA----YIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
 
Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
43-157 1.12e-10

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 56.25  E-value: 1.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652967171  43 GVEYREGVMHTLRRDLYIGTY-----AGQPVAMFALLEHEFPNSRGlsARELMYVYVDKNYRGLGFGKQIIEEAKRLATA 117
Cdd:COG3153   21 GPGREAELVDRLREDPAAGLSlvaedDGEIVGHVALSPVDIDGEGP--ALLLGPLAVDPEYRGQGIGRALMRAALEAARE 98

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 652967171 118 VGSDLILLDTlKPSLNRLYEKHGAKVVCEGSLFSHPTDVL 157
Cdd:COG3153   99 RGARAVVLLG-DPSLLPFYERFGFRPAGELGLTLGPDEVF 137
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 58-144 4.13e-10

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 54.67  E-value: 4.13e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652967171  58 LYIGTYAGQPVAmFALLEHEfpNSRGLsarELMYVYVDKNYRGLGFGKQIIEEAKRLATAVGSDLILLDTL--KPSLNRL 135
Cdd:COG0454   36 FIAVDDKGEPIG-FAGLRRL--DDKVL---ELKRLYVLPEYRGKGIGKALLEALLEWARERGCTALELDTLdgNPAAIRF 109


                 ....*....
gi 652967171 136 YEKHGAKVV 144
Cdd:COG0454  110 YERLGFKEI 118
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 71-157 4.49e-09

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 50.81  E-value: 4.49e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652967171  71 FALLEHEFPNSRGlsarELMYVYVDKNYRGLGFGKQIIEEAKRLATAVGSDLILLDTLK--PSLNRLYEKHGAKVVCEGS 148
Cdd:COG0456    2 FALLGLVDGGDEA----EIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREdnEAAIALYEKLGFEEVGERP 77


                 ....*....
gi 652967171 149 LFSHPTDVL 157
Cdd:COG0456   78 NYYGDDALV 86
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 46-149 7.30e-09

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 51.15  E-value: 7.30e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652967171  46 YREGVMHTLRRDLYIGTYAGQPVAMFALleHEFPNSRGlsarELMYVYVDKNYRGLGFGKQIIEEAKRLATAVGSDLILL 125
Cdd:COG1246   18 IRPYALEEEIGEFWVAEEDGEIVGCAAL--HPLDEDLA----ELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFL 91

                         90       100
                 ....*....|....*....|....
gi 652967171 126 DTLKPSLnRLYEKHGAKVVCEGSL 149
Cdd:COG1246   92 LTTSAAI-HFYEKLGFEEIDKEDL 114
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 55-140 1.18e-08

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 49.38  E-value: 1.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652967171   55 RRDLYIGTYAGQPVAMFALLEHEfpnsrGLSARELMYVYVDKNYRGLGFGKQIIEEAKRLATAVGSDLILLDTLKPSLnR 134
Cdd:pfam13508   2 GGRFFVAEDDGKIVGFAALLPLD-----DEGALAELRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELETTNRAA-A 75


                  ....*.
gi 652967171  135 LYEKHG 140
Cdd:pfam13508  76 FYEKLG 81
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 58-140 7.56e-08

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 48.28  E-value: 7.56e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652967171   58 LYIGTYAGQPVAMFALLEHEFPNSRGlsarELMYVYVDKNYRGLGFGKQIIEEAKRLATAVGSDLILLDTLKPSLN--RL 135
Cdd:pfam00583  35 FFVAEEDGELVGFASLSIIDDEPPVG----EIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFLEVAADNLAaiAL 110


                  ....*
gi 652967171  136 YEKHG 140
Cdd:pfam00583 111 YEKLG 115
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
66-146 5.55e-06

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 42.59  E-value: 5.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652967171  66 QPVAMFALlehefpNSRGLSARELMYVYVDKNYRGLGFGKQIIEEAKRLATAVGSDLILLDTLK--PSLNRLYEKHGAKV 143
Cdd:COG3393    1 ELVAMAGV------RAESPGVAEISGVYTHPEYRGRGLASALVAALAREALARGARTPFLYVDAdnPAARRLYERLGFRP 74


                 ...
gi 652967171 144 VCE 146
Cdd:COG3393   75 VGE 77
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 58-126 6.47e-06

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 41.88  E-value: 6.47e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 652967171  58 LYIGTYAGQPVAMFALLEHEFPNSRGlsarELMYVYVDKNYRGLGFGKQIIEEAKRLATAVGSDLILLD 126
Cdd:cd04301    1 FLVAEDDGEIVGFASLSPDGSGGDTA----YIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
92-144 1.16e-05

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 43.06  E-value: 1.16e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 652967171  92 VYVDKNYRGLGFGKQIIEEAKRLATAVGSDLILLDTL---KPSLnRLYEKHGAKVV 144
Cdd:COG1247   86 IYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLadnEASI-ALYEKLGFEEV 140
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
92-146 6.43e-05

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 40.55  E-value: 6.43e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 652967171  92 VYVDKNYRGLGFGKQIIEEAKRLATAVGSDLILLD---TLKPslnrLYEKHGAKVVCE 146
Cdd:COG2153   64 VAVLPEYRGQGLGRALMEAAIEEARERGARRIVLSaqaHAVG----FYEKLGFVPVGE 117
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 92-144 4.46e-03

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 35.32  E-value: 4.46e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 652967171   92 VYVDKNYRGLGFGKQIIEEAKRLATAVGSDLILLdTLKPSLN--RLYEKHGAKVV 144
Cdd:pfam13673  57 LFVDPDYQGQGIGKALLEAVEDYAEKDGIKLSEL-TVNASPYavPFYEKLGFRAT 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH