|
Name |
Accession |
Description |
Interval |
E-value |
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
1-483 |
0e+00 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 844.42 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 1 MLEQAQRVLKDIFGYDSFRGRQGAIIERVANGGDALVLMPTGGGKSLCFQVPGLLRDGLCVVVSPLIALMDDQVATLDEL 80
Cdd:COG0514 1 LRDDALEVLKRVFGYDSFRPGQEEIIEAVLAGRDALVVMPTGGGKSLCYQLPALLLPGLTLVVSPLIALMKDQVDALRAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 81 GVSAAALNSTLNAEQQRELANRIRLGEVKMLYLAPERLVQPRMLSFLQNLKIALFAIDEAHCVSQWGHDFRPEYLQLGQL 160
Cdd:COG0514 81 GIRAAFLNSSLSAEERREVLRALRAGELKLLYVAPERLLNPRFLELLRRLKISLFAIDEAHCISQWGHDFRPDYRRLGEL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 161 AELFPDVPRIALTATADKRTREEIVTRLHLQNAERFLSSFDRPNIFYRIVPK--EQPRKQLLAFLSERRSDAGIVYCLSR 238
Cdd:COG0514 161 RERLPNVPVLALTATATPRVRADIAEQLGLEDPRVFVGSFDRPNLRLEVVPKppDDKLAQLLDFLKEHPGGSGIVYCLSR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 239 KKVDEVAVFLSENGYPALPYHAGLPSETRAANQKRFLNEEGLIMVATIAFGMGIDKPNVRFVAHMDLPKSLEAYYQETGR 318
Cdd:COG0514 241 KKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEVDVIVATIAFGMGIDKPDVRFVIHYDLPKSIEAYYQEIGR 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 319 AGRDGLPADAWMAYGLQDVLMLKQMLQNSEGDERHKRLEQHKLDAMLALCEETRCRRQTLLAYFDEDMPNPCGHCDNCVD 398
Cdd:COG0514 321 AGRDGLPAEALLLYGPEDVAIQRFFIEQSPPDEERKRVERAKLDAMLAYAETTGCRRQFLLRYFGEELAEPCGNCDNCLG 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 399 GVQTWDATEPARQALSAIYRTGQRYGVGHLVDVLLGKSNDKVQSFGHQHLSVFGVGKARTEAEWRSLFRQLVARGLADID 478
Cdd:COG0514 401 PPETFDGTEAAQKALSCVYRTGQRFGAGHVIDVLRGSKNEKIRQFGHDKLSTYGIGKDLSDKEWRSVIRQLLAQLFGERK 480
|
....*
gi 637098164 479 LEGYG 483
Cdd:COG0514 481 LERYG 485
|
|
| recQ |
TIGR01389 |
ATP-dependent DNA helicase RecQ; The ATP-dependent DNA helicase RecQ of E. coli is about 600 ... |
5-595 |
0e+00 |
|
ATP-dependent DNA helicase RecQ; The ATP-dependent DNA helicase RecQ of E. coli is about 600 residues long. This model represents bacterial proteins with a high degree of similarity in domain architecture and in primary sequence to E. coli RecQ. The model excludes eukaryotic and archaeal proteins with RecQ-like regions, as well as more distantly related bacterial helicases related to RecQ. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273594 [Multi-domain] Cd Length: 591 Bit Score: 827.79 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 5 AQRVLKDIFGYDSFRGRQGAIIERVANGGDALVLMPTGGGKSLCFQVPGLLRDGLCVVVSPLIALMDDQVATLDELGVSA 84
Cdd:TIGR01389 1 AQQVLKRTFGYDDFRPGQEEIISHVLDGRDVLVVMPTGGGKSLCYQVPALLLKGLTVVISPLISLMKDQVDQLRAAGVAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 85 AALNSTLNAEQQRELANRIRLGEVKMLYLAPERLVQPRMLSFLQNLKIALFAIDEAHCVSQWGHDFRPEYLQLGQLAELF 164
Cdd:TIGR01389 81 AYLNSTLSAKEQQDIEKALVNGELKLLYVAPERLEQDYFLNMLQRIPIALVAVDEAHCVSQWGHDFRPEYQRLGSLAERF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 165 PDVPRIALTATADKRTREEIVTRLHLQNAERFLSSFDRPNIFYRIVPKEQPRKQLLAFLSERRSDAGIVYCLSRKKVDEV 244
Cdd:TIGR01389 161 PQVPRIALTATADAETRQDIRELLRLADANEFITSFDRPNLRFSVVKKNNKQKFLLDYLKKHRGQSGIIYASSRKKVEEL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 245 AVFLSENGYPALPYHAGLPSETRAANQKRFLNEEGLIMVATIAFGMGIDKPNVRFVAHMDLPKSLEAYYQETGRAGRDGL 324
Cdd:TIGR01389 241 AERLESQGISALAYHAGLSNKVRAENQEDFLYDDVKVMVATNAFGMGIDKPNVRFVIHYDMPGNLESYYQEAGRAGRDGL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 325 PADAWMAYGLQDVLMLKQMLQNSEGDERHKRLEQHKLDAMLALCEETRCRRQTLLAYFDEDMPNPCGHCDNCVDGVQTWD 404
Cdd:TIGR01389 321 PAEAILLYSPADIALLKRRIEQSEADDDYKQIEREKLRAMIAYCETQTCRRAYILRYFGENEVEPCGNCDNCLDPPKSYD 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 405 ATEPARQALSAIYRTGQRYGVGHLVDVLLGKSNDKVQSFGHQHLSVFGVGKARTEAEWRSLFRQLVARGLADIDLEGYGG 484
Cdd:TIGR01389 401 ATVEAQKALSCVYRMGQRFGVGYIIEVLRGSKNDKILQKGHDQLSTYGIGKDYTQKEWRSLIDQLIAEGLLTENDEIYIG 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 485 LRLSDTCRPLLRGEVSLELRRDlkpqTTSRSSSGSPASQLVRGEEREQWEALRALRRKLAEEHGVPPYVIFPDSTLLEML 564
Cdd:TIGR01389 481 LQLTEAARKVLKNEVEVLLRPF----KVVAKEKTRVQKNLSVGVDNALFEALRELRKEQADEQNVPPYVIFSDSTLREMA 556
|
570 580 590
....*....|....*....|....*....|.
gi 637098164 565 RSKPGSMAEMAKVSGVGARKLERYGDAFLEV 595
Cdd:TIGR01389 557 EKRPATLNALLKIKGVGQNKLDRYGEAFLEV 587
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
4-596 |
0e+00 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 679.90 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 4 QAQRVLKDIFGYDSFRGRQGAIIERVANGGDALVLMPTGGGKSLCFQVPGLLRDGLCVVVSPLIALMDDQVATLDELGVS 83
Cdd:PRK11057 12 LAKQVLQETFGYQQFRPGQQEIIDAVLSGRDCLVVMPTGGGKSLCYQIPALVLDGLTLVVSPLISLMKDQVDQLLANGVA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 84 AAALNSTLNAEQQRELANRIRLGEVKMLYLAPERLVQPRMLSFLQNLKIALFAIDEAHCVSQWGHDFRPEYLQLGQLAEL 163
Cdd:PRK11057 92 AACLNSTQTREQQLEVMAGCRTGQIKLLYIAPERLMMDNFLEHLAHWNPALLAVDEAHCISQWGHDFRPEYAALGQLRQR 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 164 FPDVPRIALTATADKRTREEIVTRLHLQNAERFLSSFDRPNIFYRIVPKEQPRKQLLAFLSERRSDAGIVYCLSRKKVDE 243
Cdd:PRK11057 172 FPTLPFMALTATADDTTRQDIVRLLGLNDPLIQISSFDRPNIRYTLVEKFKPLDQLMRYVQEQRGKSGIIYCNSRAKVED 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 244 VAVFLSENGYPALPYHAGLPSETRAANQKRFLNEEGLIMVATIAFGMGIDKPNVRFVAHMDLPKSLEAYYQETGRAGRDG 323
Cdd:PRK11057 252 TAARLQSRGISAAAYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGMGINKPNVRFVVHFDIPRNIESYYQETGRAGRDG 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 324 LPADAWMAYGLQDVLMLKQMLQNSEGDERhKRLEQHKLDAMLALCEETRCRRQTLLAYFDEDMPNPCGHCDNCVDGVQTW 403
Cdd:PRK11057 332 LPAEAMLFYDPADMAWLRRCLEEKPAGQQ-QDIERHKLNAMGAFAEAQTCRRLVLLNYFGEGRQEPCGNCDICLDPPKQY 410
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 404 DATEPARQALSAIYRTGQRYGVGHLVDVLLGKSNDKVQSFGHQHLSVFGVGKARTEAEWRSLFRQLVARGLADIDLEGYG 483
Cdd:PRK11057 411 DGLEDAQKALSCIYRVNQRFGMGYVVEVLRGANNQRIRDYGHDKLKVYGIGRDKSHEHWVSVIRQLIHLGLVTQNIAQHS 490
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 484 GLRLSDTCRPLLRGEVSLEL---RRD-LKPQTTSRSSSgspasqlvRGEEREQWEALRALRRKLAEEHGVPPYVIFPDST 559
Cdd:PRK11057 491 ALQLTEAARPVLRGEVSLQLavpRIVaLKPRAMQKSFG--------GNYDRKLFAKLRKLRKSIADEENIPPYVVFNDAT 562
|
570 580 590
....*....|....*....|....*....|....*..
gi 637098164 560 LLEMLRSKPGSMAEMAKVSGVGARKLERYGDAFLEVL 596
Cdd:PRK11057 563 LIEMAEQMPITASEMLSVNGVGQRKLERFGKPFMALI 599
|
|
| recQ_fam |
TIGR00614 |
ATP-dependent DNA helicase, RecQ family; All proteins in this family for which functions are ... |
8-457 |
1.71e-171 |
|
ATP-dependent DNA helicase, RecQ family; All proteins in this family for which functions are known are 3'-5' DNA-DNA helicases. These proteins are used for recombination, recombinational repair, and possibly maintenance of chromosome stability. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129701 [Multi-domain] Cd Length: 470 Bit Score: 499.30 E-value: 1.71e-171
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 8 VLKDIFGYDSFRGRQGAIIERVANGGDALVLMPTGGGKSLCFQVPGLLRDGLCVVVSPLIALMDDQVATLDELGVSAAAL 87
Cdd:TIGR00614 2 ILKKYFGLSSFRPVQLEVINAVLLGRDCFVVMPTGGGKSLCYQLPALYSDGITLVISPLISLMEDQVLQLQALGIPATFL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 88 NSTLNAEQQRELANRIRLGEVKMLYLAPERLVqpRMLSFLQNL----KIALFAIDEAHCVSQWGHDFRPEYLQLGQLAEL 163
Cdd:TIGR00614 82 NSAQTKEQQLNVLTDLKDGKIKLLYVTPEKIS--ASNRLLQTLeerkGITLIAVDEAHCISQWGHDFRPDYKALGSLKQK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 164 FPDVPRIALTATADKRTREEIVTRLHLQNAERFLSSFDRPNIFYRIVPK-EQPRKQLLAFL-SERRSDAGIVYCLSRKKV 241
Cdd:TIGR00614 160 FPNVPVMALTATASPSVREDILRQLNLLNPQIFCTSFDRPNLYYEVRRKtPKILEDLLRFIrKEFEGKSGIIYCPSRKKV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 242 DEVAVFLSENGYPALPYHAGLPSETRAANQKRFLNEEGLIMVATIAFGMGIDKPNVRFVAHMDLPKSLEAYYQETGRAGR 321
Cdd:TIGR00614 240 EQVAAELQKLGLAAGAYHAGLEDSARDDVQHKFQRDEIQVVVATVAFGMGINKPDVRFVIHYSLPKSMESYYQESGRAGR 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 322 DGLPADAWMAYGLQDVLMLKQMLQnSEGDERHKRLEQHKLDAMLALCEETRCRRQTLLAYFDEDMPN----------PCG 391
Cdd:TIGR00614 320 DGLPSECHLFYAPADMNRLRRLLM-EEPDGNFRTYKLKLYEMMEYCLNSSTCRRLILLSYFGEKGFNksfcimgtekCCD 398
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 637098164 392 HCDNCVDGV------QTWDATEPARQALSAIYRTGQRYGVGHLVDVLLGKSNDKVQSFGHQHLSVFGVGKAR 457
Cdd:TIGR00614 399 NCCKRLDYKtkdvtdKVYDFGPQAQKALSAVGRLNQKFGMGYPVDFLRGSNSQKIRDGGFRKHSLYGRGKDE 470
|
|
| PLN03137 |
PLN03137 |
ATP-dependent DNA helicase; Q4-like; Provisional |
10-596 |
9.29e-117 |
|
ATP-dependent DNA helicase; Q4-like; Provisional
Pssm-ID: 215597 [Multi-domain] Cd Length: 1195 Bit Score: 378.47 E-value: 9.29e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 10 KDIFGYDSFRGRQGAIIERVANGGDALVLMPTGGGKSLCFQVPGLLRDGLCVVVSPLIALMDDQVATLDELGVSAAALNS 89
Cdd:PLN03137 453 KKVFGNHSFRPNQREIINATMSGYDVFVLMPTGGGKSLTYQLPALICPGITLVISPLVSLIQDQIMNLLQANIPAASLSA 532
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 90 TLN-AEQQ---RELANRirLGEVKMLYLAPERLVQPRMLsfLQNLKI-------ALFAIDEAHCVSQWGHDFRPEYLQLG 158
Cdd:PLN03137 533 GMEwAEQLeilQELSSE--YSKYKLLYVTPEKVAKSDSL--LRHLENlnsrgllARFVIDEAHCVSQWGHDFRPDYQGLG 608
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 159 QLAELFPDVPRIALTATADKRTREEIVTRLHLQNAERFLSSFDRPNIFYRIVPKEqpRKQLL---AFLSERRSD-AGIVY 234
Cdd:PLN03137 609 ILKQKFPNIPVLALTATATASVKEDVVQALGLVNCVVFRQSFNRPNLWYSVVPKT--KKCLEdidKFIKENHFDeCGIIY 686
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 235 CLSRKKVDEVAVFLSENGYPALPYHAGLPSETRAANQKRFLNEEGLIMVATIAFGMGIDKPNVRFVAHMDLPKSLEAYYQ 314
Cdd:PLN03137 687 CLSRMDCEKVAERLQEFGHKAAFYHGSMDPAQRAFVQKQWSKDEINIICATVAFGMGINKPDVRFVIHHSLPKSIEGYHQ 766
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 315 ETGRAGRDGLPADAWMAYGLQDVLMLKQML--------QNSEGDERHKR----LEQH--KLDAMLALCE-ETRCRRQTLL 379
Cdd:PLN03137 767 ECGRAGRDGQRSSCVLYYSYSDYIRVKHMIsqggveqsPMAMGYNRMASsgriLETNteNLLRMVSYCEnEVDCRRFLQL 846
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 380 AYFDE--DMPNPCGHCDNC--VDGVQTWDATEPARQALSAIYRTGQRYGVGHLVDVLLGKSNDKVQSFGHQHLSVFGVGK 455
Cdd:PLN03137 847 VHFGEkfDSTNCKKTCDNCssSKSLIDKDVTEIARQLVELVKLTGERFSSAHILEVYRGSLNQYVKKHRHETLSLHGAGK 926
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 456 ARTEAEWRSLFRQLVARglaDIDLEG------YGG----LRLSDT-CRPLLRGEVSLELR------------RDLKPQTT 512
Cdd:PLN03137 927 HLSKGEASRILHYLVTE---DILAEDvkksdlYGSvsslLKVNESkAYKLFSGGQTIIMRfpssvkaskpskFEATPAKG 1003
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 513 SRSSSGSPASQLVRGEEREQ--------WEALRALRRKLAEE--HGVPPYVIFPDSTLLEMLRSKPGSMAEMAKVSGVGA 582
Cdd:PLN03137 1004 PLTSGKQSTLPMATPAQPPVdlnlsailYTALRKLRTALVKEagDGVMAYHIFGNATLQQISKRIPRTKEELLEINGLGK 1083
|
650
....*....|....
gi 637098164 583 RKLERYGDAFLEVL 596
Cdd:PLN03137 1084 AKVSKYGDRLLETI 1097
|
|
| DEXHc_RecQ |
cd17920 |
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ... |
6-201 |
4.70e-103 |
|
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.
Pssm-ID: 350678 [Multi-domain] Cd Length: 200 Bit Score: 313.32 E-value: 4.70e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 6 QRVLKDIFGYDSFRGRQGAIIERVANGGDALVLMPTGGGKSLCFQVPGLLRDGLCVVVSPLIALMDDQVATLDELGVSAA 85
Cdd:cd17920 1 EQILKEVFGYDEFRPGQLEAINAVLAGRDVLVVMPTGGGKSLCYQLPALLLDGVTLVVSPLISLMQDQVDRLQQLGIRAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 86 ALNSTLNAEQQRELANRIRLGEVKMLYLAPERLVQPRMLSFLQNLK----IALFAIDEAHCVSQWGHDFRPEYLQLGQLA 161
Cdd:cd17920 81 ALNSTLSPEEKREVLLRIKNGQYKLLYVTPERLLSPDFLELLQRLPerkrLALIVVDEAHCVSQWGHDFRPDYLRLGRLR 160
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 637098164 162 ELFPDVPRIALTATADKRTREEIVTRLHLQNAERFLSSFD 201
Cdd:cd17920 161 RALPGVPILALTATATPEVREDILKRLGLRNPVIFRASFD 200
|
|
| DEXHc_RecQ4-like |
cd18018 |
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) ... |
7-192 |
2.73e-69 |
|
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations cause Rothmund-Thomson/RAPADILINO/Baller-Gerold syndrome.
Pssm-ID: 350776 [Multi-domain] Cd Length: 201 Bit Score: 225.21 E-value: 2.73e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 7 RVLKDIFGYDSFRGRQGAIIERVANGGDALVLMPTGGGKSLCFQVPGLL----RDGLCVVVSPLIALMDDQVATLDELgV 82
Cdd:cd18018 2 KLLRRVFGHPSFRPGQEEAIARLLSGRSTLVVLPTGAGKSLCYQLPALLlrrrGPGLTLVVSPLIALMKDQVDALPRA-I 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 83 SAAALNSTLNAEQQRELANRIRLGEVKMLYLAPERLVQPRMLSFLQNLK-IALFAIDEAHCVSQWGHDFRPEYLQLGQLA 161
Cdd:cd18018 81 KAAALNSSLTREERRRILEKLRAGEVKILYVSPERLVNESFRELLRQTPpISLLVVDEAHCISEWSHNFRPDYLRLCRVL 160
|
170 180 190
....*....|....*....|....*....|..
gi 637098164 162 ELFPDVPRI-ALTATADKRTREEIVTRLHLQN 192
Cdd:cd18018 161 RELLGAPPVlALTATATKRVVEDIASHLGIPE 192
|
|
| DEXHc_RecQ1 |
cd18015 |
DEXH-box helicase domain of RecQ1; ATP-dependent DNA helicase Q1 (RecQ1) is part of the RecQ ... |
3-201 |
2.05e-66 |
|
DEXH-box helicase domain of RecQ1; ATP-dependent DNA helicase Q1 (RecQ1) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350773 [Multi-domain] Cd Length: 209 Bit Score: 218.00 E-value: 2.05e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 3 EQAQRVLKDIFGYDSFRGRQGAIIERVANGGDALVLMPTGGGKSLCFQVPGLLRDGLCVVVSPLIALMDDQVATLDELGV 82
Cdd:cd18015 4 GKVKDTLKNVFKLEKFRPLQLETINATMAGRDVFLVMPTGGGKSLCYQLPALCSDGFTLVVSPLISLMEDQLMALKKLGI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 83 SAAALNSTLNAEQQRELANRIRLG--EVKMLYLAPERLVQP-RMLSFLQNL----KIALFAIDEAHCVSQWGHDFRPEYL 155
Cdd:cd18015 84 SATMLNASSSKEHVKWVHAALTDKnsELKLLYVTPEKIAKSkRFMSKLEKAynagRLARIAIDEVHCCSQWGHDFRPDYK 163
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 637098164 156 QLGQLAELFPDVPRIALTATADKRTREEIVTRLHLQNAERFLSSFD 201
Cdd:cd18015 164 KLGILKRQFPNVPILGLTATATSKVLKDVQKILCIQKCLTFTASFN 209
|
|
| DEXHc_RecQ2_BLM |
cd18016 |
DEAH-box helicase domain of RecQ2; ATP-dependent DNA helicase Q2 (RecQ2, also called Bloom ... |
1-201 |
4.40e-58 |
|
DEAH-box helicase domain of RecQ2; ATP-dependent DNA helicase Q2 (RecQ2, also called Bloom syndrome protein homolog or BLM) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations in RecQ2 cause Bloom syndrome.
Pssm-ID: 350774 [Multi-domain] Cd Length: 208 Bit Score: 195.43 E-value: 4.40e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 1 MLEQAQRVLKDIFGYDSFRGRQGAIIERVANGGDALVLMPTGGGKSLCFQVPGLLRDGLCVVVSPLIALMDDQVATLDEL 80
Cdd:cd18016 1 HSKEMMKIFHKKFGLHQFRTNQLEAINAALLGEDCFVLMPTGGGKSLCYQLPACVSPGVTVVISPLRSLIVDQVQKLTSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 81 GVSAAALNSTLNAEQQRELANRIRLGE--VKMLYLAPERL-VQPRMLSFLQNLK----IALFAIDEAHCVSQWGHDFRPE 153
Cdd:cd18016 81 DIPATYLTGDKTDAEATKIYLQLSKKDpiIKLLYVTPEKIsASNRLISTLENLYerklLARFVIDEAHCVSQWGHDFRPD 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 637098164 154 YLQLGQLAELFPDVPRIALTATADKRTREEIVTRLHLQNAERFLSSFD 201
Cdd:cd18016 161 YKRLNMLRQKFPSVPMMALTATATPRVQKDILNQLKMLRPQVFTMSFN 208
|
|
| DEXHc_RecQ3 |
cd18017 |
DEAH-box helicase domain of RecQ3; DEAD-like helicase RecQ3 (also called Werner syndrome ... |
9-201 |
2.46e-57 |
|
DEAH-box helicase domain of RecQ3; DEAD-like helicase RecQ3 (also called Werner syndrome ATP-dependent helicase or WRN) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations cause Werner's syndrome.
Pssm-ID: 350775 [Multi-domain] Cd Length: 193 Bit Score: 193.07 E-value: 2.46e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 9 LKDIFGYDSFRGRQGAIIERV-ANGGDALVLMPTGGGKSLCFQVPGLLRDGLCVVVSPLIALMDDQVATLDELGVSAAAL 87
Cdd:cd18017 4 LNEYFGHSSFRPVQWKVIRSVlEERRDNLVVMATGYGKSLCYQYPSVLLNSLTLVISPLISLMEDQVLQLVMSNIPACFL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 88 NStlnaEQQRELANRIRLGEVKMLYLAPErLVQpRMLSFLQNLK--IALFAIDEAHCVSQWGHDFRPEYLQLGQLAELFP 165
Cdd:cd18017 84 GS----AQSQNVLDDIKMGKIRVIYVTPE-FVS-KGLELLQQLRngITLIAIDEAHCVSQWGHDFRSSYRHLGSIRNRLP 157
|
170 180 190
....*....|....*....|....*....|....*.
gi 637098164 166 DVPRIALTATADKRTREEIVTRLHLQNAERFLSSFD 201
Cdd:cd18017 158 NVPIVALTATATPSVRDDIIKNLNLRNPQITCTSFD 193
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
202-332 |
2.99e-57 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 190.50 E-value: 2.99e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 202 RPNIFYRIVPKEQPRKQLL---AFLSERRSDAGIVYCLSRKKVDEVAVFLSENGYPALPYHAGLPSETRAANQKRFLNEE 278
Cdd:cd18794 1 RPNLFYSVRPKDKKDEKLDllkRIKVEHLGGSGIIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLRDK 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 637098164 279 GLIMVATIAFGMGIDKPNVRFVAHMDLPKSLEAYYQETGRAGRDGLPADAWMAY 332
Cdd:cd18794 81 IQVIVATVAFGMGIDKPDVRFVIHYSLPKSMESYYQESGRAGRDGLPSECILFY 134
|
|
| DEXHc_RecQ5 |
cd18014 |
DEAH-box helicase domain of RecQ5; ATP-dependent DNA helicase Q5 (RecQ5) is part of the RecQ ... |
6-196 |
1.20e-54 |
|
DEAH-box helicase domain of RecQ5; ATP-dependent DNA helicase Q5 (RecQ5) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350772 [Multi-domain] Cd Length: 205 Bit Score: 186.14 E-value: 1.20e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 6 QRVLKDIFGYDSFRG--RQGAIIERVANGGDALVLMPTGGGKSLCFQVPGLLRDGLCVVVSPLIALMDDQVATLDELGVS 83
Cdd:cd18014 1 RSTLKKVFGHSDFKSplQEKATMAVVKGNKDVFVCMPTGAGKSLCYQLPALLAKGITIVISPLIALIQDQVDHLKTLKIR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 84 AAALNSTLNAEQQRELANRIR--LGEVKMLYLAPERLVQPRMLSFLQNL----KIALFAIDEAHCVSQWGHDFRPEYLQL 157
Cdd:cd18014 81 VDSLNSKLSAQERKRIIADLEseKPQTKFLYITPEMAATSSFQPLLSSLvsrnLLSYLVVDEAHCVSQWGHDFRPDYLRL 160
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 637098164 158 GQLAELFPDVPRIALTATADKRTREEIVTRLHL-QNAERF 196
Cdd:cd18014 161 GALRSRYGHVPWVALTATATPQVQEDIFAQLRLkKPVAIF 200
|
|
| RQC |
pfam09382 |
RQC domain; This DNA-binding domain is found in the RecQ helicase among others and has a ... |
400-506 |
1.71e-41 |
|
RQC domain; This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure. The RQC domain, found only in RecQ family enzymes, is a high affinity G4 DNA binding domain.
Pssm-ID: 462780 [Multi-domain] Cd Length: 108 Bit Score: 146.53 E-value: 1.71e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 400 VQTWDATEPARQALSAIYRTGQRYGVGHLVDVLLGKSNDKVQSFGHQHLSVFGVGKARTEAEWRSLFRQLVARGLADIDL 479
Cdd:pfam09382 2 PETVDVTEEAQKILSCVYRTGQRFGAGHLIDVLRGSKNKKIRQLGHDKLSTFGIGKDLSKKEWRRIIRQLIAEGYLEVDI 81
|
90 100
....*....|....*....|....*..
gi 637098164 480 EGYGGLRLSDTCRPLLRGEVSLELRRD 506
Cdd:pfam09382 82 EFYSVLKLTPKAREVLKGEEKVMLRVP 108
|
|
| DpdF |
NF041063 |
protein DpdF; |
8-337 |
8.74e-41 |
|
protein DpdF;
Pssm-ID: 468990 [Multi-domain] Cd Length: 813 Bit Score: 160.08 E-value: 8.74e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 8 VLKDIFGYDSFRGR-QGAIIERV--ANGGDALVL-MPTGGGKSLCFQVPGLL---RDGLCVVVSPLIALMDDQVATLDEL 80
Cdd:NF041063 130 FLAEALGFTHYRSPgQREAVRAAllAPPGSTLIVnLPTGSGKSLVAQAPALLasrQGGLTLVVVPTVALAIDQERRAREL 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 81 GVSAA-------ALNSTLNAEQQRELANRIRLGEVKMLYLAPERLVQpRMLSFLQNL----KIALFAIDEAHCVSQWGHD 149
Cdd:NF041063 210 LRRAGpdlggplAWHGGLSAEERAAIRQRIRDGTQRILFTSPESLTG-SLRPALFDAaeagLLRYLVVDEAHLVDQWGDG 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 150 FRPEYLQL-GQLAELF-----PDVPR-IALTATADKRTREEIvTRL--HLQNAERFLSSFDRPNI---FYRIVPKEQPRK 217
Cdd:NF041063 289 FRPEFQLLaGLRRSLLrlapsGRPFRtLLLSATLTESTLDTL-ETLfgPPGPFIVVSAVQLRPEPaywVAKCDSEEERRE 367
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 218 QLLAFLSERRSDAgIVYCLSRKKVDEVAVFLSENGYPALpyhAGLPSETRAANQKRFL---NEEGL-IMVATIAFGMGID 293
Cdd:NF041063 368 RVLEALRHLPRPL-ILYVTKVEDAEAWLQRLRAAGFRRV---ALFHGDTPDAERERLIeqwRENELdIVVATSAFGLGMD 443
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 637098164 294 KPNVRFVAHMDLPKSLEAYYQETGRAGRDGLPADAWMAYGLQDV 337
Cdd:NF041063 444 KSDVRTVIHACVPETLDRFYQEVGRGGRDGKASLSLLIYTPDDL 487
|
|
| RQC |
smart00956 |
This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix ... |
404-495 |
9.44e-38 |
|
This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; The RQC domain, found only in RecQ family enzymes, is a high affinity G4 DNA binding domain.
Pssm-ID: 214936 [Multi-domain] Cd Length: 92 Bit Score: 135.30 E-value: 9.44e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 404 DATEPARQALSAIYRTGQRYGVGHLVDVLLGKSNDKVQSFGHQHLSVFGVGKARTEAEWRSLFRQLVARGLADIDLEGYG 483
Cdd:smart00956 1 DVTEEAQKLLSCVYRTGQRFGAGHVIDVLRGSKNKKIRQKGHDRLSTFGIGKDLSKKEWRRLIRQLIAEGYLREDGGRYP 80
|
90
....*....|..
gi 637098164 484 GLRLSDTCRPLL 495
Cdd:smart00956 81 YLKLTEKARPVL 92
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
22-182 |
1.45e-24 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 100.78 E-value: 1.45e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 22 QGAIIERVANGGDALVLMPTGGGKSLCFQVPGL------LRDGLCVVVSPLIALMDDQVATLDELG-VSAAALNSTLNAE 94
Cdd:pfam00270 4 QAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALealdklDNGPQALVLAPTRELAEQIYEELKKLGkGLGLKVASLLGGD 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 95 QQRELANRIRlgEVKMLYLAPERLVQprMLSFLQNLK-IALFAIDEAHCVSQWGhdFRPEYLQLgqLAELFPDVPRIALT 173
Cdd:pfam00270 84 SRKEQLEKLK--GPDILVGTPGRLLD--LLQERKLLKnLKLLVLDEAHRLLDMG--FGPDLEEI--LRRLPKKRQILLLS 155
|
....*....
gi 637098164 174 ATADKRTRE 182
Cdd:pfam00270 156 ATLPRNLED 164
|
|
| RecQ_Zn_bind |
pfam16124 |
RecQ zinc-binding; This domain is the zinc-binding domain of ATP-dependent DNA helicase RecQ. |
334-396 |
8.78e-23 |
|
RecQ zinc-binding; This domain is the zinc-binding domain of ATP-dependent DNA helicase RecQ.
Pssm-ID: 465031 [Multi-domain] Cd Length: 66 Bit Score: 91.97 E-value: 8.78e-23
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 637098164 334 LQDVLMLKQMLQNSEGDERHKRLEQHKLDAMLALCEET-RCRRQTLLAYFDED-MPNPCGHCDNC 396
Cdd:pfam16124 1 YQDVVRLRFLIEQSEADEERKEVELQKLQAMVAYCENTtDCRRKQLLRYFGEEfDSEPCGNCDNC 65
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
242-323 |
1.14e-22 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 92.27 E-value: 1.14e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 242 DEVAVFLSENGYPALPYHAGLPSETRAANQKRFLNEEGLIMVATIAFGMGIDKPNVRFVAHMDLPKSLEAYYQETGRAGR 321
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80
|
..
gi 637098164 322 DG 323
Cdd:smart00490 81 AG 82
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
13-203 |
3.93e-21 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 91.78 E-value: 3.93e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 13 FGYDSFRGRQGAIIERVANG-GDALVLMPTGGGKSLCFQVPGLLR-----DGLCVVVSPLIALMDDQVATLDELGVSAAA 86
Cdd:smart00487 4 FGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEAlkrgkGGRVLVLVPTRELAEQWAEELKKLGPSLGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 87 LNSTL-NAEQQRELANRIRLGEVKMLYLAPERLVQPRMLSFLQNLKIALFAIDEAHCVSQWGhdFRPEYLQLgqLAELFP 165
Cdd:smart00487 84 KVVGLyGGDSKREQLRKLESGKTDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDGG--FGDQLEKL--LKLLPK 159
|
170 180 190
....*....|....*....|....*....|....*...
gi 637098164 166 DVPRIALTATADKRTREeiVTRLHLQNAERFLSSFDRP 203
Cdd:smart00487 160 NVQLLLLSATPPEEIEN--LLELFLNDPVFIDVGFTPL 195
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
219-323 |
6.78e-21 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 88.04 E-value: 6.78e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 219 LLAFLSERRSDAGIVYCLSRKKVDEvAVFLSENGYPALPYHAGLPSETRAANQKRFLNEEGLIMVATIAFGMGIDKPNVR 298
Cdd:pfam00271 6 LLELLKKERGGKVLIFSQTKKTLEA-ELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPDVD 84
|
90 100
....*....|....*....|....*
gi 637098164 299 FVAHMDLPKSLEAYYQETGRAGRDG 323
Cdd:pfam00271 85 LVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| HRDC |
pfam00570 |
HRDC domain; The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic ... |
529-596 |
3.35e-20 |
|
HRDC domain; The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic acid binding. Mutations in the HRDC domain cause human disease. It is interesting to note that the RecQ helicase in Deinococcus radiodurans has three tandem HRDC domains.
Pssm-ID: 425755 [Multi-domain] Cd Length: 68 Bit Score: 84.89 E-value: 3.35e-20
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 637098164 529 EREQWEALRALRRKLAEEHGVPPYVIFPDSTLLEMLRSKPGSMAEMAKVSGVGARKLERYGDAFLEVL 596
Cdd:pfam00570 1 QLALLKALREWRDELAREEDVPPYVIFPDKTLLEIAEKLPRTLEELLAIPGVGPRKVERYGEEILAAI 68
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
206-324 |
2.15e-18 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 81.78 E-value: 2.15e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 206 FYRIVPKEQPRKQLLAFLSERRSDA-GIVYCLSRKKVDEVAVFLSENGYPALPYHAGLPSETRAANQKRFLNEEGLIMVA 284
Cdd:cd18787 4 LYVVVEEEEKKLLLLLLLLEKLKPGkAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRVLVA 83
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 637098164 285 TIAFGMGIDKPNVRFVAHMDLPKSLEAYYQE---TGRAGRDGL 324
Cdd:cd18787 84 TDVAARGLDIPGVDHVINYDLPRDAEDYVHRigrTGRAGRKGT 126
|
|
| HRDC |
smart00341 |
Helicase and RNase D C-terminal; Hypothetical role in nucleic acid binding. Mutations in the ... |
528-596 |
4.61e-15 |
|
Helicase and RNase D C-terminal; Hypothetical role in nucleic acid binding. Mutations in the HRDC domain cause human disease.
Pssm-ID: 128635 [Multi-domain] Cd Length: 81 Bit Score: 70.79 E-value: 4.61e-15
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 637098164 528 EEREQWEALRALRRKLAEEHGVPPYVIFPDSTLLEMLRSKPGSMAEMAKVSGVGARKLERYGDAFLEVL 596
Cdd:smart00341 3 RQLRLLRRLRQWRDEIARREDVPPYFVLPDETLIKMAAALPTNVSELLAIDGVGEEKARRYGKDLLAVI 71
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
32-175 |
3.75e-14 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 70.12 E-value: 3.75e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 32 GGDALVLMPTGGGKSLCFQVPGLLRD----GLCVVVSPLIALMDDQVATLDEL---GVSAAALNSTLNAEQQRELANR-- 102
Cdd:cd00046 1 GENVLITAPTGSGKTLAALLAALLLLlkkgKKVLVLVPTKALALQTAERLRELfgpGIRVAVLVGGSSAEEREKNKLGda 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 637098164 103 -IRLGEVKMLYlapeRLVQPRMLSFLQNLKiaLFAIDEAHCVSQWGHDFRPEYLQLGQLAelFPDVPRIALTAT 175
Cdd:cd00046 81 dIIIATPDMLL----NLLLREDRLFLKDLK--LIIVDEAHALLIDSRGALILDLAVRKAG--LKNAQVILLSAT 146
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
27-319 |
1.75e-13 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 73.52 E-value: 1.75e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 27 ERVANGGDALVLMPTGGGKSLCFQ--VPGLLRDGLCVVVSPLIALMDDQVATLdelgvsAAALNSTLNAEQQRELANRIR 104
Cdd:COG1061 95 ALERGGGRGLVVAPTGTGKTVLALalAAELLRGKRVLVLVPRRELLEQWAEEL------RRFLGDPLAGGGKKDSDAPIT 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 105 LGEVKMLYLAPErlvqprmLSFLQNlKIALFAIDEAHcvsqwgHDFRPEYLQLgqlAELFPDVPRIALTAT---ADKRTR 181
Cdd:COG1061 169 VATYQSLARRAH-------LDELGD-RFGLVIIDEAH------HAGAPSYRRI---LEAFPAAYRLGLTATpfrSDGREI 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 182 -----EEIVTRLHLQNAER--FLSSFDRPNIFYRIVPK-------EQPRKQLLAFLSER-------------RSDAGIVY 234
Cdd:COG1061 232 llflfDGIVYEYSLKEAIEdgYLAPPEYYGIRVDLTDEraeydalSERLREALAADAERkdkilrellrehpDDRKTLVF 311
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 235 CLSRKKVDEVAVFLSENGYPALPYHAGLPSETRAANQKRFLNEEGLIMVATIAFGMGIDKPNVRFVAHMDLPKSLEAYYQ 314
Cdd:COG1061 312 CSSVDHAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELRILVTVDVLNEGVDVPRLDVAILLRPTGSPREFIQ 391
|
....*
gi 637098164 315 ETGRA 319
Cdd:COG1061 392 RLGRG 396
|
|
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
203-324 |
4.51e-12 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 68.64 E-value: 4.51e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 203 PNI--FYRIVPKEQPRKQLLAFLSERRSDAGIVYCLSRKKVDEVAVFLSENGYPALPYHAGLPSETRAANQKRFLNEEGL 280
Cdd:COG0513 214 ETIeqRYYLVDKRDKLELLRRLLRDEDPERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIR 293
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 637098164 281 IMVAT-IAfGMGIDKPNVRFVAHMDLPKSLEAYyq---eTGRAGRDGL 324
Cdd:COG0513 294 VLVATdVA-ARGIDIDDVSHVINYDLPEDPEDYvhrigrTGRAGAEGT 340
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
26-323 |
9.83e-11 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 65.24 E-value: 9.83e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 26 IERVANGGDALVLMPTGGGKSLCFQVP---GLLRDGLC--VVVSPLIALMDDQVATLDEL------GVSAAALNSTLNAE 94
Cdd:COG1205 65 IEAARAGKNVVIATPTASGKSLAYLLPvleALLEDPGAtaLYLYPTKALARDQLRRLRELaealglGVRVATYDGDTPPE 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 95 QQRELANRIRLgevkmlylapeRLVQPRML------------SFLQNLKiaLFAIDEAHC---V--SQWGHDFRpeylQL 157
Cdd:COG1205 145 ERRWIREHPDI-----------VLTNPDMLhygllphhtrwaRFFRNLR--YVVIDEAHTyrgVfgSHVANVLR----RL 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 158 GQLAELFPDVPR-IALTATadkrtreeivtrlhLQNAERFLSS-FDRP---------------NIFYRIVPKEQPR---- 216
Cdd:COG1205 208 RRICRHYGSDPQfILASAT--------------IGNPAEHAERlTGRPvtvvdedgsprgertFVLWNPPLVDDGIrrsa 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 217 ----KQLLAFLSERRSdAGIVYCLSRKKVDEVAVFLSEN-GYPAL-----PYHAGLPSETRAANQKRFLNEEGLIMVATI 286
Cdd:COG1205 274 laeaARLLADLVREGL-RTLVFTRSRRGAELLARYARRAlREPDLadrvaAYRAGYLPEERREIERGLRSGELLGVVSTN 352
|
330 340 350
....*....|....*....|....*....|....*..
gi 637098164 287 AFGMGIDKPNVRFVAHMDLPKSLEAYYQETGRAGRDG 323
Cdd:COG1205 353 ALELGIDIGGLDAVVLAGYPGTRASFWQQAGRAGRRG 389
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
32-323 |
2.06e-10 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 63.64 E-value: 2.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 32 GGDALVLMPTGGGKSLCFQVPG--------LLRDG---LCVVVSPLIALMDDQVATLDELGVS-----AAALNSTLNAEQ 95
Cdd:PTZ00110 167 GRDMIGIAETGSGKTLAFLLPAivhinaqpLLRYGdgpIVLVLAPTRELAEQIREQCNKFGASskirnTVAYGGVPKRGQ 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 96 QRELANrirlgEVKMLYLAPERLVqprmlSFLQ----NL-KIALFAIDEAHCVSQWGhdFRPEYLQLgqLAELFPDVPRI 170
Cdd:PTZ00110 247 IYALRR-----GVEILIACPGRLI-----DFLEsnvtNLrRVTYLVLDEADRMLDMG--FEPQIRKI--VSQIRPDRQTL 312
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 171 ALTATADKRT--------REEI----VTRLHLQNAERFlssfdRPNIFyrIVPKEQPRKQLLAFLSERRSDAG--IVYCL 236
Cdd:PTZ00110 313 MWSATWPKEVqslardlcKEEPvhvnVGSLDLTACHNI-----KQEVF--VVEEHEKRGKLKMLLQRIMRDGDkiLIFVE 385
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 237 SRKKVDEVAVFLSENGYPALPYHAGLPSETRAANQKRFLNEEGLIMVATIAFGMGIDKPNVRFVAHMDLPKSLEAYYQET 316
Cdd:PTZ00110 386 TKKGADFLTKELRLDGWPALCIHGDKKQEERTWVLNEFKTGKSPIMIATDVASRGLDVKDVKYVINFDFPNQIEDYVHRI 465
|
....*..
gi 637098164 317 GRAGRDG 323
Cdd:PTZ00110 466 GRTGRAG 472
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
22-141 |
7.34e-09 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 55.67 E-value: 7.34e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 22 QGAIIERVANGGDALVLMPTGGGKSLCFQVP---GLLRD-GLC-VVVSPLIALMDDQVATLDEL--GVSAAALNSTLNAE 94
Cdd:cd17923 5 QAEAIEAARAGRSVVVTTGTASGKSLCYQLPileALLRDpGSRaLYLYPTKALAQDQLRSLRELleQLGLGIRVATYDGD 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 637098164 95 QQRELANRIRLGEVKMLylaperLVQPRML------------SFLQNLKiaLFAIDEAH 141
Cdd:cd17923 85 TPREERRAIIRNPPRIL------LTNPDMLhyallphhdrwaRFLRNLR--YVVLDEAH 135
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
14-328 |
8.47e-09 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 58.65 E-value: 8.47e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 14 GYDSFRGRQGAIIERVANGGDALVLMPTGGGKSLCFQVPGLLR-------------DGLCVVVSP---LIALMDDQVATL 77
Cdd:PLN00206 140 GYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTASFLVPIISRcctirsghpseqrNPLAMVLTPtreLCVQVEDQAKVL 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 78 DELGVSAAALNSTLNAEQQRelANRIRLGeVKMLYLAPERLVQPRMLSFLQNLKIALFAIDEAHCVSQWGhdFRPEYLQL 157
Cdd:PLN00206 220 GKGLPFKTALVVGGDAMPQQ--LYRIQQG-VELIVGTPGRLIDLLSKHDIELDNVSVLVLDEVDCMLERG--FRDQVMQI 294
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 158 GQ-LAElfpdvPRIAL-TATAdkrtreeivtrlhLQNAERFLSSFDRPNIFYRIVPKEQP----------------RKQL 219
Cdd:PLN00206 295 FQaLSQ-----PQVLLfSATV-------------SPEVEKFASSLAKDIILISIGNPNRPnkavkqlaiwvetkqkKQKL 356
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 220 LAFL--SERRSDAGIVYCLSRKKVDevavFLSE-----NGYPALPYHAGLPSETRAANQKRFLNEEGLIMVATIAFGMGI 292
Cdd:PLN00206 357 FDILksKQHFKPPAVVFVSSRLGAD----LLANaitvvTGLKALSIHGEKSMKERREVMKSFLVGEVPVIVATGVLGRGV 432
|
330 340 350
....*....|....*....|....*....|....*.
gi 637098164 293 DKPNVRFVAHMDLPKSLEAYYQETGRAGRDGLPADA 328
Cdd:PLN00206 433 DLLRVRQVIIFDMPNTIKEYIHQIGRASRMGEKGTA 468
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
97-323 |
1.04e-08 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 57.91 E-value: 1.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 97 RELANRIRLGeVKMLYLAPERLVQPRMLSFLQNLKIALFAIDEAHCVSQWGhdFRpeylqlGQLAELF----PDVPRIAL 172
Cdd:PTZ00424 137 RDDINKLKAG-VHMVVGTPGRVYDMIDKRHLRVDDLKLFILDEADEMLSRG--FK------GQIYDVFkklpPDVQVALF 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 173 TATADKRTREeiVTRLHLQNAERFLSSFDRPNI-----FYRIVPKEQPRKQLLAFLSERRS-DAGIVYCLSRKKVDEVAV 246
Cdd:PTZ00424 208 SATMPNEILE--LTTKFMRDPKRILVKKDELTLegirqFYVAVEKEEWKFDTLCDLYETLTiTQAIIYCNTRRKVDYLTK 285
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 637098164 247 FLSENGYPALPYHAGLPSETRAANQKRFLNEEGLIMVATIAFGMGIDKPNVRFVAHMDLPKSLEAYYQETGRAGRDG 323
Cdd:PTZ00424 286 KMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLLARGIDVQQVSLVINYDLPASPENYIHRIGRSGRFG 362
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
281-323 |
1.79e-08 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 51.94 E-value: 1.79e-08
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 637098164 281 IMVATIAFGMGIDKPNVRFVAHMDLPKSLEAYYQETGRAGRDG 323
Cdd:cd18785 25 ILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGG 67
|
|
| SF2_C_Hrq |
cd18797 |
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role ... |
232-326 |
3.08e-07 |
|
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. HrQ family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350184 [Multi-domain] Cd Length: 146 Bit Score: 50.33 E-value: 3.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 232 IVYCLSRKKVDEVAVFLSE--NGYPALP-----YHAGLPSETRAANQKRFLNEEGLIMVATIAFGMGIDKPNVRFVAHMD 304
Cdd:cd18797 39 IVFCRSRKLAELLLRYLKArlVEEGPLAskvasYRAGYLAEDRREIEAELFNGELLGVVATNALELGIDIGGLDAVVLAG 118
|
90 100
....*....|....*....|..
gi 637098164 305 LPKSLEAYYQETGRAGRDGLPA 326
Cdd:cd18797 119 YPGSLASLWQQAGRAGRRGKDS 140
|
|
| Rnd |
COG0349 |
Ribonuclease D [Translation, ribosomal structure and biogenesis]; |
530-596 |
4.01e-06 |
|
Ribonuclease D [Translation, ribosomal structure and biogenesis];
Pssm-ID: 440118 [Multi-domain] Cd Length: 365 Bit Score: 49.49 E-value: 4.01e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 530 REQWEALRAL---RRKLAEEHGVPPYVIFPDSTLLEMLRSKPGSMAEMAKVSGVGARKLERYGDAFLEVL 596
Cdd:COG0349 207 PRQLAVLRELaawREREARKRDVPRNRVLKDEALLELARRQPKSLEELARLRGLSPGEIRRHGEELLAAV 276
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
32-328 |
7.63e-06 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 49.18 E-value: 7.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 32 GGDALVLMPTGGGKSLCFQV---------PGLL----RDGLCVVVSPL----IALMDDQVATLDELGVSAAALNSTLNAE 94
Cdd:PRK04537 46 GGDVAGQAQTGTGKTLAFLVavmnrllsrPALAdrkpEDPRALILAPTrelaIQIHKDAVKFGADLGLRFALVYGGVDYD 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 95 QQRELanrIRLGeVKMLYLAPERLV----QPRMLSfLQNLKIALfaIDEAHCVSQWG--HDFR------PEYLQLGQLae 162
Cdd:PRK04537 126 KQREL---LQQG-VDVIIATPGRLIdyvkQHKVVS-LHACEICV--LDEADRMFDLGfiKDIRfllrrmPERGTRQTL-- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 163 LFpdvprialTATADKRTREeiVTRLHLQNAERFLSSFD-------RPNIFYRIVPKEQPrkQLLAFLSERRSDAGIVYC 235
Cdd:PRK04537 197 LF--------SATLSHRVLE--LAYEHMNEPEKLVVETEtitaarvRQRIYFPADEEKQT--LLLGLLSRSEGARTMVFV 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 236 LSRKKVDEVAVFLSENGYPALPYHAGLPSETRAANQKRFLNEEGLIMVATIAFGMGIDKPNVRFVAHMDLPKSLEAYYQE 315
Cdd:PRK04537 265 NTKAFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVATDVAARGLHIDGVKYVYNYDLPFDAEDYVHR 344
|
330
....*....|...
gi 637098164 316 TGRAGRDGLPADA 328
Cdd:PRK04537 345 IGRTARLGEEGDA 357
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
14-323 |
1.22e-05 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 48.69 E-value: 1.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 14 GYDSFRGRQGAIIERVANGGDALVLMPTGGGKSLCFQVPgLLRDGLCVVVSPLIALMddqvATLDELGVSAAalnstlna 93
Cdd:PRK11634 25 GYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLP-LLHNLDPELKAPQILVL----APTRELAVQVA-------- 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 94 EQQRELANRIRLGEVKMLYLAPERLVQPRMLS------------FLQNLK--------IALFAIDEAHcvsqwghdfrpE 153
Cdd:PRK11634 92 EAMTDFSKHMRGVNVVALYGGQRYDVQLRALRqgpqivvgtpgrLLDHLKrgtldlskLSGLVLDEAD-----------E 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 154 YLQLGQLAEL------FPDVPRIAL-TATADKRTREeiVTRLHLQNAE--RFLSSF-DRPNIF--YRIVPKEQPRKQLLA 221
Cdd:PRK11634 161 MLRMGFIEDVetimaqIPEGHQTALfSATMPEAIRR--ITRRFMKEPQevRIQSSVtTRPDISqsYWTVWGMRKNEALVR 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 222 FLSERRSDAGIVYCLSRKKVDEVAVFLSENGYPALPYHAGLPSETRAANQKRFLNEEGLIMVATIAFGMGIDKPNVRFVA 301
Cdd:PRK11634 239 FLEAEDFDAAIIFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLERLKDGRLDILIATDVAARGLDVERISLVV 318
|
330 340
....*....|....*....|..
gi 637098164 302 HMDLPKSLEAYYQETGRAGRDG 323
Cdd:PRK11634 319 NYDIPMDSESYVHRIGRTGRAG 340
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
206-323 |
1.62e-05 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 48.01 E-value: 1.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 206 FYRIVPKEQPRKQLLAFLSERRSDAGIVYCLSRKKVDEVAVFLSENGYPALPYHAGLPSETRAANQKRFLNEEGLIMVAT 285
Cdd:PRK11192 223 YYRADDLEHKTALLCHLLKQPEVTRSIVFVRTRERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIKRLTDGRVNVLVAT 302
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 637098164 286 IAFGMGIDKPNVRFVAHMDLPKSLEAYYQ---ETGRAGRDG 323
Cdd:PRK11192 303 DVAARGIDIDDVSHVINFDMPRSADTYLHrigRTGRAGRKG 343
|
|
| COG1202 |
COG1202 |
Superfamily II helicase, archaea-specific [Replication, recombination and repair]; |
207-321 |
3.38e-05 |
|
Superfamily II helicase, archaea-specific [Replication, recombination and repair];
Pssm-ID: 440815 [Multi-domain] Cd Length: 790 Bit Score: 47.19 E-value: 3.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 207 YRIVP--------KEQPRKQLLAFLSER----RSDAG-----IVYCLSRKKVDEVAVFLsenGYPALPYHAGLPSETRAA 269
Cdd:COG1202 389 ERPVPlerhltfaDGREKIRIINKLVKRefdtKSSKGyrgqtIIFTNSRRRCHEIARAL---GYKAAPYHAGLDYGERKK 465
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 637098164 270 NQKRFLNEEGLIMVATIAFGMGIDKP--NVRFvahmdlpKSL---------EAYYQETGRAGR 321
Cdd:COG1202 466 VERRFADQELAAVVTTAALAAGVDFPasQVIF-------DSLamgiewlsvQEFHQMLGRAGR 521
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
13-324 |
5.12e-05 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 46.43 E-value: 5.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 13 FGYDSFRGRQGAIIER-VANGGDALVLMPTGGGKSLCFQVP---GLLRDGLCVVVSPLIAL----MDDQVATLDELGVSA 84
Cdd:COG1204 18 RGIEELYPPQAEALEAgLLEGKNLVVSAPTASGKTLIAELAilkALLNGGKALYIVPLRALasekYREFKRDFEELGIKV 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 85 AAlnSTLNAEqqrelANRIRLGEVKMLYLAPERLVQprML----SFLQNlkIALFAIDEAHCVsqwGHDFR-PEY-LQLG 158
Cdd:COG1204 98 GV--STGDYD-----SDDEWLGRYDILVATPEKLDS--LLrngpSWLRD--VDLVVVDEAHLI---DDESRgPTLeVLLA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 159 QLAELFPDVPRIALTATadkrtreeivtrlhLQNAERFLSSFD--------RPN-----IFY----RIVPKEQPRKQLLA 221
Cdd:COG1204 164 RLRRLNPEAQIVALSAT--------------IGNAEEIAEWLDaelvksdwRPVplnegVLYdgvlRFDDGSRRSKDPTL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 222 FLSERRSDAG---IVYCLSRK-----------------------KVDEVAVFLSENGYPALPY--------------HAG 261
Cdd:COG1204 230 ALALDLLEEGgqvLVFVSSRRdaeslakkladelkrrltpeereELEELAEELLEVSEETHTNekladclekgvafhHAG 309
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 637098164 262 LPSETRAANQKRFlnEEGLI--MVAT--IAfgMGIDKP-------NVRFVAHMDLPkSLEaYYQETGRAGRDGL 324
Cdd:COG1204 310 LPSELRRLVEDAF--REGLIkvLVATptLA--AGVNLParrviirDTKRGGMVPIP-VLE-FKQMAGRAGRPGY 377
|
|
| PRK01172 |
PRK01172 |
ATP-dependent DNA helicase; |
26-323 |
2.54e-04 |
|
ATP-dependent DNA helicase;
Pssm-ID: 100801 [Multi-domain] Cd Length: 674 Bit Score: 44.49 E-value: 2.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 26 IERVANGGDALVLMPTGGGKSLCFQ---VPGLLRDGLCVVVSPLIALMDDQVATLDELgvsaaalnstlnaeqqRELANR 102
Cdd:PRK01172 31 IEQLRKGENVIVSVPTAAGKTLIAYsaiYETFLAGLKSIYIVPLRSLAMEKYEELSRL----------------RSLGMR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 103 IRLG------------EVKMLYLAPER---LVQ--PRMLSflqnlKIALFAIDEAHCVsqwGHDFRPEYLQ--LGQLAEL 163
Cdd:PRK01172 95 VKISigdyddppdfikRYDVVILTSEKadsLIHhdPYIIN-----DVGLIVADEIHII---GDEDRGPTLEtvLSSARYV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 164 FPDVPRIALTATADKRTreEIVTRLhlqNAERFLSSFdRP-----NIFY--RIVPKEQPRKQL--LAFLSERRSDAG--I 232
Cdd:PRK01172 167 NPDARILALSATVSNAN--ELAQWL---NASLIKSNF-RPvplklGILYrkRLILDGYERSQVdiNSLIKETVNDGGqvL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 233 VYCLSRKKVDEVAVFLSE---------------NGYP-----ALP-----YHAGLPSETRAANQKRFLNEEGLIMVATIA 287
Cdd:PRK01172 241 VFVSSRKNAEDYAEMLIQhfpefndfkvssennNVYDdslneMLPhgvafHHAGLSNEQRRFIEEMFRNRYIKVIVATPT 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 637098164 288 FGMGIDKPnVRFVAHMDLPKSLEAYY---------QETGRAGRDG 323
Cdd:PRK01172 321 LAAGVNLP-ARLVIVRDITRYGNGGIrylsnmeikQMIGRAGRPG 364
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
32-175 |
4.87e-04 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 41.41 E-value: 4.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 32 GGDALVLMPTGGGKSLCFQVPGLLR------DGL-CVVVSPLIALMDDQVATLDE------LGVSAAALNS-TLNAEQQR 97
Cdd:cd17922 1 GRNVLIAAPTGSGKTEAAFLPALSSladepeKGVqVLYISPLKALINDQERRLEEpldeidLEIPVAVRHGdTSQSEKAK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 98 ELANRIRLgevkmLYLAPERL----VQPRMLSFLQNLKiaLFAIDEAHCV--SQWGHDFRpeyLQLGQLAELF-PDVPRI 170
Cdd:cd17922 81 QLKNPPGI-----LITTPESLelllVNKKLRELFAGLR--YVVVDEIHALlgSKRGVQLE---LLLERLRKLTgRPLRRI 150
|
....*
gi 637098164 171 ALTAT 175
Cdd:cd17922 151 GLSAT 155
|
|
| SF2_C_Ski2 |
cd18795 |
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ... |
232-324 |
4.91e-04 |
|
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350182 [Multi-domain] Cd Length: 154 Bit Score: 41.00 E-value: 4.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 232 IVYCLSRKKVDEVAVFLSENGYpalpYHAGLPSETRAANQKRFLneEGLIMV--ATIAFGMGIDKPnvrfvAH------- 302
Cdd:cd18795 47 LVFCSSRKECEKTAKDLAGIAF----HHAGLTREDRELVEELFR--EGLIKVlvATSTLAAGVNLP-----ARtviikgt 115
|
90 100
....*....|....*....|....*....
gi 637098164 303 -------MDLPKSLEaYYQETGRAGRDGL 324
Cdd:cd18795 116 qrydgkgYRELSPLE-YLQMIGRAGRPGF 143
|
|
| SF2_C_suv3 |
cd18805 |
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene ... |
233-327 |
2.46e-03 |
|
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene encodes a DNA and RNA helicase, which is localized in mitochondria and is a subunit of the degradosome complex involved in regulation of RNA surveillance and turnover. SUV3 exhibits DNA and RNA-dependent ATPase, DNA and RNA-binding and DNA and RNA unwinding activities. SUV3 is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350192 [Multi-domain] Cd Length: 135 Bit Score: 38.69 E-value: 2.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637098164 233 VYCLSRKKVDEVAVFLSENG--YPALPYhAGLPSETRAANQKRFL--NEEGLIMVATIAFGMGIDKpNVRFVAHMDLPK- 307
Cdd:cd18805 22 VVAFSRKDIFSLKREIEKRTglKCAVIY-GALPPETRRQQARLFNdpESGYDVLVASDAIGMGLNL-NIRRVIFSSLSKf 99
|
90 100
....*....|....*....|....*...
gi 637098164 308 --------SLEAYYQETGRAGRDGLPAD 327
Cdd:cd18805 100 dgnemrplSPSEVKQIAGRAGRFGSHFP 127
|
|
| Rnd |
COG0349 |
Ribonuclease D [Translation, ribosomal structure and biogenesis]; |
534-599 |
6.20e-03 |
|
Ribonuclease D [Translation, ribosomal structure and biogenesis];
Pssm-ID: 440118 [Multi-domain] Cd Length: 365 Bit Score: 39.47 E-value: 6.20e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 637098164 534 EALRALRRKLAEEHGVPPYVIFPDSTLLEMLRSKPGSMAEMAKvsgvGARKlERYGDAFLEVLSGK 599
Cdd:COG0349 305 KLLKALLKEVAEELGVAPELLASRKDLEALARWGELADPPLLS----GWRR-ELFGEELLALLEGE 365
|
|
| |
