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Conserved domains on  [gi|556388829|ref|WP_023303143|]
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MULTISPECIES: hypothetical protein [Enterobacterales]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
vWFA super family cl00057
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ...
220-259 6.85e-03

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.


The actual alignment was detected with superfamily member PRK05325:

Pssm-ID: 469594  Cd Length: 401  Bit Score: 38.28  E-value: 6.85e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 556388829 220 ETNPAPFTNSSMLSMLRPSGS---FEKYMAVKFYFLfIYLFLK 259
Cdd:PRK05325 214 EKVPKPESQAVMFCLMDVSGSmdeAEKDLAKRFFFL-LYLFLR 255
 
Name Accession Description Interval E-value
PRK05325 PRK05325
hypothetical protein; Provisional
220-259 6.85e-03

hypothetical protein; Provisional


Pssm-ID: 235409  Cd Length: 401  Bit Score: 38.28  E-value: 6.85e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 556388829 220 ETNPAPFTNSSMLSMLRPSGS---FEKYMAVKFYFLfIYLFLK 259
Cdd:PRK05325 214 EKVPKPESQAVMFCLMDVSGSmdeAEKDLAKRFFFL-LYLFLR 255
 
Name Accession Description Interval E-value
PRK05325 PRK05325
hypothetical protein; Provisional
220-259 6.85e-03

hypothetical protein; Provisional


Pssm-ID: 235409  Cd Length: 401  Bit Score: 38.28  E-value: 6.85e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 556388829 220 ETNPAPFTNSSMLSMLRPSGS---FEKYMAVKFYFLfIYLFLK 259
Cdd:PRK05325 214 EKVPKPESQAVMFCLMDVSGSmdeAEKDLAKRFFFL-LYLFLR 255
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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