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Conserved domains on  [gi|553308335|ref|WP_023053413|]
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MULTISPECIES: endonuclease III [Megasphaera]

Protein Classification

endonuclease III domain-containing protein( domain architecture ID 11415064)

endonuclease III domain-containing protein such as endonuclease III, a DNA repair enzyme that has both DNA N-glycosylase and AP-lyase activities

CATH:  1.10.1670.10
Gene Ontology:  GO:0016798|GO:0006284|GO:0051539
PubMed:  10908318|1411536
SCOP:  4001141

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nth COG0177
Endonuclease III [Replication, recombination and repair];
12-206 6.32e-115

Endonuclease III [Replication, recombination and repair];


:

Pssm-ID: 439947 [Multi-domain]  Cd Length: 198  Bit Score: 325.51  E-value: 6.32e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553308335  12 LQRFQAEYGIMKPALHYGTPFELLVAVVLSAQCTDERVNIVTAGLFPEYNTPQKMLSLGVLGLEEKIRTCGLYRSKAKNL 91
Cdd:COG0177    1 LERLKELYPDAKTELDYRDPFELLVATILSAQTTDERVNKATPRLFARYPTPEALAAADLEELEELIRPIGLYRNKAKNI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553308335  92 MATCAILCETYHGEVPRDFDSLVTLPGVGRKTANVLISVLFDIPAIAVDTHVFRVANRMQLAVGKTPLEVEMGLQKAIPK 171
Cdd:COG0177   81 IALARILVEKYGGEVPETREELESLPGVGRKTANVVLNFAFGKPAIAVDTHVHRVSNRLGLVPGKDPEEVEKDLMKLIPK 160

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 553308335 172 EWWSRAHHWLIWHGRRICKARTPLCEECFQSDLCP 206
Cdd:COG0177  161 EYWGDLHHLLILHGRYICKARKPKCEECPLADLCP 195
 
Name Accession Description Interval E-value
Nth COG0177
Endonuclease III [Replication, recombination and repair];
12-206 6.32e-115

Endonuclease III [Replication, recombination and repair];


Pssm-ID: 439947 [Multi-domain]  Cd Length: 198  Bit Score: 325.51  E-value: 6.32e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553308335  12 LQRFQAEYGIMKPALHYGTPFELLVAVVLSAQCTDERVNIVTAGLFPEYNTPQKMLSLGVLGLEEKIRTCGLYRSKAKNL 91
Cdd:COG0177    1 LERLKELYPDAKTELDYRDPFELLVATILSAQTTDERVNKATPRLFARYPTPEALAAADLEELEELIRPIGLYRNKAKNI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553308335  92 MATCAILCETYHGEVPRDFDSLVTLPGVGRKTANVLISVLFDIPAIAVDTHVFRVANRMQLAVGKTPLEVEMGLQKAIPK 171
Cdd:COG0177   81 IALARILVEKYGGEVPETREELESLPGVGRKTANVVLNFAFGKPAIAVDTHVHRVSNRLGLVPGKDPEEVEKDLMKLIPK 160

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 553308335 172 EWWSRAHHWLIWHGRRICKARTPLCEECFQSDLCP 206
Cdd:COG0177  161 EYWGDLHHLLILHGRYICKARKPKCEECPLADLCP 195
nth TIGR01083
endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily ...
 5-196 6.24e-99

endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily (HhH-GPD: Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate). The major members of the superfamily are nth and mutY. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273434 [Multi-domain]  Cd Length: 192  Bit Score: 285.04  E-value: 6.24e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553308335    5 KKKKMEMLQRFQAEYGIMKPALHYGTPFELLVAVVLSAQCTDERVNIVTAGLFPEYNTPQKMLSLGVLGLEEKIRTCGLY 84
Cdd:TIGR01083   1 RQKAQEILERLRKNYPHPTTELDFNNPFELLVATILSAQATDKRVNKATPKLFEVYPTPQALAQAGLEELEEYIKSIGLY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553308335   85 RSKAKNLMATCAILCETYHGEVPRDFDSLVTLPGVGRKTANVLISVLFDIPAIAVDTHVFRVANRMQLAVGKTPLEVEMG 164
Cdd:TIGR01083  81 RNKAKNIIELCRKLVERYGGEVPEDREELVKLPGVGRKTANVVLNVAFGIPAIAVDTHVFRVSNRLGLSKGKDPIKVEED 160

                         170       180       190
                  ....*....|....*....|....*....|..
gi 553308335  165 LQKAIPKEWWSRAHHWLIWHGRRICKARTPLC 196
Cdd:TIGR01083 161 LMKLVPREFWVKLHHWLILHGRYTCKARKPLC 192
PRK10702 PRK10702
endonuclease III; Provisional
 3-210 3.32e-78

endonuclease III; Provisional


Pssm-ID: 182661 [Multi-domain]  Cd Length: 211  Bit Score: 233.37  E-value: 3.32e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553308335   3 MTKKKKMEMLQRFQAEYGIMKPALHYGTPFELLVAVVLSAQCTDERVNIVTAGLFPEYNTPQKMLSLGVLGLEEKIRTCG 82
Cdd:PRK10702   1 MNKAKRLEILTRLRDNNPHPTTELNFSSPFELLIAVLLSAQATDVSVNKATAKLYPVANTPAAMLELGVEGVKTYIKTIG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553308335  83 LYRSKAKNLMATCAILCETYHGEVPRDFDSLVTLPGVGRKTANVLISVLFDIPAIAVDTHVFRVANRMQLAVGKTPLEVE 162
Cdd:PRK10702  81 LYNSKAENVIKTCRILLEQHNGEVPEDRAALEALPGVGRKTANVVLNTAFGWPTIAVDTHIFRVCNRTQFAPGKNVEQVE 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 553308335 163 MGLQKAIPKEWWSRAHHWLIWHGRRICKARTPLCEECFQSDLCPGKEK 210
Cdd:PRK10702 161 EKLLKVVPAEFKVDCHHWLILHGRYTCIARKPRCGSCIIEDLCEYKEK 208
ENDO3c smart00478
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 40-187 1.34e-53

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 214684 [Multi-domain]  Cd Length: 149  Bit Score: 168.60  E-value: 1.34e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553308335    40 LSAQCTDERVNIVTAGLFPEYNTPQKMLSLGVLGLEEKIRTCGLYRSKAKNLMATCAILCETYHGEVPRDFDSLVTLPGV 119
Cdd:smart00478   1 LSQQTTDERVNKATERLFEKFPTPEDLAAADEEELEELIRGLGFYRRKARYLIELARILVEEYGGEVPDDREELLKLPGV 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 553308335   120 GRKTANVLISVLFDIPAIAVDTHVFRVANRMQLAVGK-TPLEVEMGLQKAIPKEWWSRAHHWLIWHGRR 187
Cdd:smart00478  81 GRKTANAVLSFALGKPFIPVDTHVLRIAKRLGLVDKKsTPEEVEKLLEKLLPEEDWRELNLLLIDFGRT 149
ENDO3c cd00056
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 32-185 5.67e-49

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 238013 [Multi-domain]  Cd Length: 158  Bit Score: 157.02  E-value: 5.67e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553308335  32 FELLVAVVLSAQCTDERVNIVTAGLFPEYN-TPQKMLSLGVLGLEEKIRTCGlYRSKAKNLMATCAILCETYHGEV---P 107
Cdd:cd00056    1 FEVLVSEILSQQTTDKAVNKAYERLFERYGpTPEALAAADEEELRELIRSLG-YRRKAKYLKELARAIVEGFGGLVlddP 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 553308335 108 RDFDSLVTLPGVGRKTANVLISVLFDIPAIAVDTHVFRVANRMQLAV-GKTPLEVEMGLQKAIPKEWWSRAHHWLIWHG 185
Cdd:cd00056   80 DAREELLALPGVGRKTANVVLLFALGPDAFPVDTHVRRVLKRLGLIPkKKTPEELEELLEELLPKPYWGEANQALMDLG 158
HhH-GPD pfam00730
HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of ...
 36-171 4.26e-35

HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate. This includes endonuclease III, EC:4.2.99.18 and MutY an A/G-specific adenine glycosylase, both have a C terminal 4Fe-4S cluster. The family also includes 8-oxoguanine DNA glycosylases. The methyl-CPG binding protein MBD4 also contains a related domain that is a thymine DNA glycosylase. The family also includes DNA-3-methyladenine glycosylase II EC:3.2.2.21 and other members of the AlkA family.


Pssm-ID: 425841 [Multi-domain]  Cd Length: 141  Bit Score: 120.85  E-value: 4.26e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553308335   36 VAVVLSAQCTDERVNIVTAGLFPE-YNTPQKMLSLGVLGLEEKIRTCGLYRSKAKNLMATCAILCETYHGEVPRDFDSLV 114
Cdd:pfam00730   1 VSAILSQQTSDKAVNKITERLFEKfFPTPEDLADADEEELRELIRGLGFYRRKAKYLKELARILVEGYGGEVPLDEEELE 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 553308335  115 T-LPGVGRKTANVLISVLF--DIPAIAVDTHVFRVANRMQLAVG-KTPLEVEMGLQKAIPK 171
Cdd:pfam00730  81 AlLKGVGRWTAEAVLIFALgrPDPLPVVDTHVRRVLKRLGLIKEkPTPKEVERELEELWPP 141
 
Name Accession Description Interval E-value
Nth COG0177
Endonuclease III [Replication, recombination and repair];
12-206 6.32e-115

Endonuclease III [Replication, recombination and repair];


Pssm-ID: 439947 [Multi-domain]  Cd Length: 198  Bit Score: 325.51  E-value: 6.32e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553308335  12 LQRFQAEYGIMKPALHYGTPFELLVAVVLSAQCTDERVNIVTAGLFPEYNTPQKMLSLGVLGLEEKIRTCGLYRSKAKNL 91
Cdd:COG0177    1 LERLKELYPDAKTELDYRDPFELLVATILSAQTTDERVNKATPRLFARYPTPEALAAADLEELEELIRPIGLYRNKAKNI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553308335  92 MATCAILCETYHGEVPRDFDSLVTLPGVGRKTANVLISVLFDIPAIAVDTHVFRVANRMQLAVGKTPLEVEMGLQKAIPK 171
Cdd:COG0177   81 IALARILVEKYGGEVPETREELESLPGVGRKTANVVLNFAFGKPAIAVDTHVHRVSNRLGLVPGKDPEEVEKDLMKLIPK 160

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 553308335 172 EWWSRAHHWLIWHGRRICKARTPLCEECFQSDLCP 206
Cdd:COG0177  161 EYWGDLHHLLILHGRYICKARKPKCEECPLADLCP 195
nth TIGR01083
endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily ...
 5-196 6.24e-99

endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily (HhH-GPD: Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate). The major members of the superfamily are nth and mutY. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273434 [Multi-domain]  Cd Length: 192  Bit Score: 285.04  E-value: 6.24e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553308335    5 KKKKMEMLQRFQAEYGIMKPALHYGTPFELLVAVVLSAQCTDERVNIVTAGLFPEYNTPQKMLSLGVLGLEEKIRTCGLY 84
Cdd:TIGR01083   1 RQKAQEILERLRKNYPHPTTELDFNNPFELLVATILSAQATDKRVNKATPKLFEVYPTPQALAQAGLEELEEYIKSIGLY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553308335   85 RSKAKNLMATCAILCETYHGEVPRDFDSLVTLPGVGRKTANVLISVLFDIPAIAVDTHVFRVANRMQLAVGKTPLEVEMG 164
Cdd:TIGR01083  81 RNKAKNIIELCRKLVERYGGEVPEDREELVKLPGVGRKTANVVLNVAFGIPAIAVDTHVFRVSNRLGLSKGKDPIKVEED 160

                         170       180       190
                  ....*....|....*....|....*....|..
gi 553308335  165 LQKAIPKEWWSRAHHWLIWHGRRICKARTPLC 196
Cdd:TIGR01083 161 LMKLVPREFWVKLHHWLILHGRYTCKARKPLC 192
PRK10702 PRK10702
endonuclease III; Provisional
 3-210 3.32e-78

endonuclease III; Provisional


Pssm-ID: 182661 [Multi-domain]  Cd Length: 211  Bit Score: 233.37  E-value: 3.32e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553308335   3 MTKKKKMEMLQRFQAEYGIMKPALHYGTPFELLVAVVLSAQCTDERVNIVTAGLFPEYNTPQKMLSLGVLGLEEKIRTCG 82
Cdd:PRK10702   1 MNKAKRLEILTRLRDNNPHPTTELNFSSPFELLIAVLLSAQATDVSVNKATAKLYPVANTPAAMLELGVEGVKTYIKTIG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553308335  83 LYRSKAKNLMATCAILCETYHGEVPRDFDSLVTLPGVGRKTANVLISVLFDIPAIAVDTHVFRVANRMQLAVGKTPLEVE 162
Cdd:PRK10702  81 LYNSKAENVIKTCRILLEQHNGEVPEDRAALEALPGVGRKTANVVLNTAFGWPTIAVDTHIFRVCNRTQFAPGKNVEQVE 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 553308335 163 MGLQKAIPKEWWSRAHHWLIWHGRRICKARTPLCEECFQSDLCPGKEK 210
Cdd:PRK10702 161 EKLLKVVPAEFKVDCHHWLILHGRYTCIARKPRCGSCIIEDLCEYKEK 208
ENDO3c smart00478
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 40-187 1.34e-53

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 214684 [Multi-domain]  Cd Length: 149  Bit Score: 168.60  E-value: 1.34e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553308335    40 LSAQCTDERVNIVTAGLFPEYNTPQKMLSLGVLGLEEKIRTCGLYRSKAKNLMATCAILCETYHGEVPRDFDSLVTLPGV 119
Cdd:smart00478   1 LSQQTTDERVNKATERLFEKFPTPEDLAAADEEELEELIRGLGFYRRKARYLIELARILVEEYGGEVPDDREELLKLPGV 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 553308335   120 GRKTANVLISVLFDIPAIAVDTHVFRVANRMQLAVGK-TPLEVEMGLQKAIPKEWWSRAHHWLIWHGRR 187
Cdd:smart00478  81 GRKTANAVLSFALGKPFIPVDTHVLRIAKRLGLVDKKsTPEEVEKLLEKLLPEEDWRELNLLLIDFGRT 149
ENDO3c cd00056
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 32-185 5.67e-49

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 238013 [Multi-domain]  Cd Length: 158  Bit Score: 157.02  E-value: 5.67e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553308335  32 FELLVAVVLSAQCTDERVNIVTAGLFPEYN-TPQKMLSLGVLGLEEKIRTCGlYRSKAKNLMATCAILCETYHGEV---P 107
Cdd:cd00056    1 FEVLVSEILSQQTTDKAVNKAYERLFERYGpTPEALAAADEEELRELIRSLG-YRRKAKYLKELARAIVEGFGGLVlddP 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 553308335 108 RDFDSLVTLPGVGRKTANVLISVLFDIPAIAVDTHVFRVANRMQLAV-GKTPLEVEMGLQKAIPKEWWSRAHHWLIWHG 185
Cdd:cd00056   80 DAREELLALPGVGRKTANVVLLFALGPDAFPVDTHVRRVLKRLGLIPkKKTPEELEELLEELLPKPYWGEANQALMDLG 158
HhH-GPD pfam00730
HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of ...
 36-171 4.26e-35

HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate. This includes endonuclease III, EC:4.2.99.18 and MutY an A/G-specific adenine glycosylase, both have a C terminal 4Fe-4S cluster. The family also includes 8-oxoguanine DNA glycosylases. The methyl-CPG binding protein MBD4 also contains a related domain that is a thymine DNA glycosylase. The family also includes DNA-3-methyladenine glycosylase II EC:3.2.2.21 and other members of the AlkA family.


Pssm-ID: 425841 [Multi-domain]  Cd Length: 141  Bit Score: 120.85  E-value: 4.26e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553308335   36 VAVVLSAQCTDERVNIVTAGLFPE-YNTPQKMLSLGVLGLEEKIRTCGLYRSKAKNLMATCAILCETYHGEVPRDFDSLV 114
Cdd:pfam00730   1 VSAILSQQTSDKAVNKITERLFEKfFPTPEDLADADEEELRELIRGLGFYRRKAKYLKELARILVEGYGGEVPLDEEELE 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 553308335  115 T-LPGVGRKTANVLISVLF--DIPAIAVDTHVFRVANRMQLAVG-KTPLEVEMGLQKAIPK 171
Cdd:pfam00730  81 AlLKGVGRWTAEAVLIFALgrPDPLPVVDTHVRRVLKRLGLIKEkPTPKEVERELEELWPP 141
HP0602 COG2231
3-Methyladenine DNA glycosylase, HhH-GPD/Endo3 superfamily [Replication, recombination and ...
 9-206 8.68e-24

3-Methyladenine DNA glycosylase, HhH-GPD/Endo3 superfamily [Replication, recombination and repair];


Pssm-ID: 441832 [Multi-domain]  Cd Length: 220  Bit Score: 94.14  E-value: 8.68e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553308335   9 MEMLQRFQAEYGIMKpaLHYG--------TPFELLVAVVLsAQCTD----ERV--NIVTAGLFpeynTPQKMLSLGVLGL 74
Cdd:COG2231    1 MNTKEDLLEIYERLL--EHYGpqhwwpaeTPFEVIVGAIL-TQNTSwknvEKAiaNLKEAGLL----DPEALAALDPEEL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553308335  75 EEKIRTCGLYRSKAKNLMATCAILCETYHGEVPRDF--------DSLVTLPGVGRKTANVLISVLFDIPAIAVDTHVFRV 146
Cdd:COG2231   74 AELIRPSGFYNQKAKRLKNLARWLVERYGGGLEKLKalpteelrEELLSLKGIGPETADSILLYAFNRPVFVVDAYTRRI 153

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 553308335 147 ANRMQLAVGKTP-LEVEMGLQKAIP------KEWwsraHHWLIWHGRRICKARtPLCEECFQSDLCP 206
Cdd:COG2231  154 FSRLGLIEEDASyDELQRLFEENLPpdvalyNEF----HALIVEHGKEYCKKK-PKCEECPLRDLCP 215
PRK10880 PRK10880
adenine DNA glycosylase;
82-206 3.95e-08

adenine DNA glycosylase;


Pssm-ID: 182805 [Multi-domain]  Cd Length: 350  Bit Score: 52.40  E-value: 3.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553308335  82 GL-YRSKAKNLMATCAILCETYHGEVPRDFDSLVTLPGVGRKTANVLISVLFDIPAIAVDTHVFRVANRMqLAVGKTP-- 158
Cdd:PRK10880  79 GLgYYARARNLHKAAQQVATLHGGEFPETFEEVAALPGVGRSTAGAILSLSLGKHFPILDGNVKRVLARC-YAVSGWPgk 157

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 553308335 159 LEVEMGL----QKAIPKEWWSRAHHWLIWHGRRICKARTPLCEecfqsdLCP 206
Cdd:PRK10880 158 KEVENRLwqlsEQVTPAVGVERFNQAMMDLGAMVCTRSKPKCE------LCP 203
PRK13910 PRK13910
DNA glycosylase MutY; Provisional
 84-150 1.69e-07

DNA glycosylase MutY; Provisional


Pssm-ID: 172427 [Multi-domain]  Cd Length: 289  Bit Score: 50.41  E-value: 1.69e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 553308335  84 YRSKAKNLMATCAILCETYHGEVPRDFDSLVTLPGVGRKTANVLISVLFDIPAIAVDTHVFRVANRM 150
Cdd:PRK13910  45 YYSRAKNLKKSAEICVKEHHSQLPNDYQSLLKLPGIGAYTANAILCFGFREKSACVDANIKRVLLRL 111
AlkA COG0122
3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [Replication, recombination and ...
 29-143 1.83e-07

3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [Replication, recombination and repair];


Pssm-ID: 439892 [Multi-domain]  Cd Length: 255  Bit Score: 49.88  E-value: 1.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553308335  29 GTPFELLVAVVLSAQCT---------------DERVNIVTAGL--FPeynTPQKMLSLGvlglEEKIRTCGLYRSKAKNL 91
Cdd:COG0122   82 PDPFEALVRAILGQQVSvaaartiwrrlvalfGEPIEGPGGGLyaFP---TPEALAAAS----EEELRACGLSRRKARYL 154

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 553308335  92 MATCAILCEtyhGEVPRDF----------DSLVTLPGVGRKTAN-VLISVL--FDI-PaiAVDTHV 143
Cdd:COG0122  155 RALARAVAD---GELDLEAlaglddeeaiARLTALPGIGPWTAEmVLLFALgrPDAfP--AGDLGL 215
HHH pfam00633
Helix-hairpin-helix motif; The helix-hairpin-helix DNA-binding motif is found to be duplicated ...
 101-130 3.39e-06

Helix-hairpin-helix motif; The helix-hairpin-helix DNA-binding motif is found to be duplicated in the central domain of RuvA. The HhH domain of DisA, a bacterial checkpoint control protein, is a DNA-binding domain.


Pssm-ID: 425789 [Multi-domain]  Cd Length: 30  Bit Score: 42.40  E-value: 3.39e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 553308335  101 TYHGEVPRDFDSLVTLPGVGRKTANVLISV 130
Cdd:pfam00633   1 SLEGLIPASVEELLALPGVGPKTAEAILSY 30
ogg TIGR00588
8-oxoguanine DNA-glycosylase (ogg); All proteins in this family for which functions are known ...
 31-149 4.00e-06

8-oxoguanine DNA-glycosylase (ogg); All proteins in this family for which functions are known are 8-oxo-guanaine DNA glycosylases that function in base excision repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). This family is distantly realted to the Nth-MutY superfamily. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 211589 [Multi-domain]  Cd Length: 310  Bit Score: 46.44  E-value: 4.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553308335   31 PFELLVAVVLSAQCTDERV------------------NIVTAGLFPeynTPQKMLSLGVlglEEKIRTCGL-YRskAKNL 91
Cdd:TIGR00588 119 PFECLISFICSSNNNIARItrmverlcqafgprlitlDGVTYHGFP---SLHALTGPEA---EAHLRKLGLgYR--ARYI 190

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 553308335   92 MATCAILCETYHGEVP----RDFD------SLVTLPGVGRKTANVLISVLFDIP-AIAVDTHVFRVANR 149
Cdd:TIGR00588 191 RETARALLEEQGGRAWlqqiRGASyedareALCELPGVGPKVADCICLMGLDKPqAVPVDVHVWRIANR 259
PRK13913 PRK13913
3-methyladenine DNA glycosylase; Provisional
 12-145 3.94e-04

3-methyladenine DNA glycosylase; Provisional


Pssm-ID: 184390  Cd Length: 218  Bit Score: 40.22  E-value: 3.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553308335  12 LQRFQAEYGIMKPALHYGTP----FELLVAVVLSAQCTDERV-----NIVTAGLFPEYNTP--QKMLSLGVLGLEEKIRT 80
Cdd:PRK13913   7 LLKALKSLDLLKNAPAWWWPnalkFEALLGAVLTQNTKFEAVeksleNLKNAFILENDDEInlKKIAYIEFSKLAECVRP 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 553308335  81 CGLYRSKAKNLMATC-AILC-----ETYHGEVprDFDSLVTLPGVGRKTANVLISVLFDIPAIAVDTHVFR 145
Cdd:PRK13913  87 SGFYNQKAKRLIDLSeNILKdfgsfENFKQEV--TREWLLDQKGIGKESADAILCYVCAKEVMVVDKYSYL 155
FES smart00525
iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); ...
 188-208 7.32e-04

iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3);


Pssm-ID: 197771 [Multi-domain]  Cd Length: 21  Bit Score: 35.60  E-value: 7.32e-04
                           10        20
                   ....*....|....*....|.
gi 553308335   188 ICKARTPLCEECFQSDLCPGK 208
Cdd:smart00525   1 ICTARKPRCDECPLKDLCPAY 21
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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