NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|529145174|ref|WP_020934918|]
View 

polyphosphate--glucose phosphotransferase [Corynebacterium maris]

Protein Classification

ROK family protein( domain architecture ID 11449187)

ROK (Repressor, ORF, Kinase) family protein functions as a sugar kinase or may act as a transcriptional regulator involved in carbohydrate-dependent transcriptional control

CATH:  3.30.420.40
Gene Ontology:  GO:0005524
PubMed:  20512568|17979299
SCOP:  3000092|4000330

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ASKHA_NBD_ROK_PPGK cd24058
nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK ...
 20-257 5.26e-123

nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK (EC 2.7.1.63/EC 2.7.1.2), also called poly(P)/ATP-glucomannokinase (GMK), poly(P) glucokinase, ATP-dependent glucokinase, or polyphosphate--glucose phosphotransferase, catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. Polyphosphate, rather than ATP, seems to be the major phosphate donor for the enzyme in Mycobacterium tuberculosis. GTP, UTP and CTP can replace ATP as phosphoryl donor. PPGK belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this family lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


:

Pssm-ID: 466908 [Multi-domain]  Cd Length: 239  Bit Score: 349.95  E-value: 5.26e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  20 FGVDVGGSGIKGAIVDLTTGEFIGDRIKILTPQPATPDAVAETIAELLDRAEWEGPVGITLPSVVKDRVALTAANIDPSW 99
Cdd:cd24058    2 LGIDIGGSGIKGAIVDTDTGELLSERIRIPTPQPATPEAVADVVAELVAHFPWFGPVGVGFPGVVRRGVVRTAANLDKSW 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174 100 VGADTGELFDRHLpGREVTVLNDADAAGLAEVAHGNPVAGAGSVIFLTFGTGIGSAMLLDGQLFPNTELGHLVIDGQEAE 179
Cdd:cd24058   82 IGFDAAKLLSKRL-GRPVRVLNDADAAGLAEMKGGAGKGEKGVVLVLTLGTGIGSALFVDGHLVPNTELGHLEIRGKDAE 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 529145174 180 WTASSAVKEREELSFKKWAKRVNAVLTEYERLFYPDAFIVGGGISRDHEKWVPRLDLRTPVHAAQLRNRAGIVGAAMA 257
Cdd:cd24058  161 ERASLGVRAREDLGWKRWAKRVNKYLQYLERLFNPDLFIIGGGNSKKADKFLPLLDVKTPVVPAVLRNDAGIVGAALL 238
 
Name Accession Description Interval E-value
ASKHA_NBD_ROK_PPGK cd24058
nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK ...
 20-257 5.26e-123

nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK (EC 2.7.1.63/EC 2.7.1.2), also called poly(P)/ATP-glucomannokinase (GMK), poly(P) glucokinase, ATP-dependent glucokinase, or polyphosphate--glucose phosphotransferase, catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. Polyphosphate, rather than ATP, seems to be the major phosphate donor for the enzyme in Mycobacterium tuberculosis. GTP, UTP and CTP can replace ATP as phosphoryl donor. PPGK belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this family lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466908 [Multi-domain]  Cd Length: 239  Bit Score: 349.95  E-value: 5.26e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  20 FGVDVGGSGIKGAIVDLTTGEFIGDRIKILTPQPATPDAVAETIAELLDRAEWEGPVGITLPSVVKDRVALTAANIDPSW 99
Cdd:cd24058    2 LGIDIGGSGIKGAIVDTDTGELLSERIRIPTPQPATPEAVADVVAELVAHFPWFGPVGVGFPGVVRRGVVRTAANLDKSW 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174 100 VGADTGELFDRHLpGREVTVLNDADAAGLAEVAHGNPVAGAGSVIFLTFGTGIGSAMLLDGQLFPNTELGHLVIDGQEAE 179
Cdd:cd24058   82 IGFDAAKLLSKRL-GRPVRVLNDADAAGLAEMKGGAGKGEKGVVLVLTLGTGIGSALFVDGHLVPNTELGHLEIRGKDAE 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 529145174 180 WTASSAVKEREELSFKKWAKRVNAVLTEYERLFYPDAFIVGGGISRDHEKWVPRLDLRTPVHAAQLRNRAGIVGAAMA 257
Cdd:cd24058  161 ERASLGVRAREDLGWKRWAKRVNKYLQYLERLFNPDLFIIGGGNSKKADKFLPLLDVKTPVVPAVLRNDAGIVGAALL 238
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 13-258 1.19e-34

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 126.55  E-value: 1.19e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  13 NDTATTAFGVDVGGSGIKGAIVDLTtGEFIgDRIKILTPQPATPDAVAETIAELLDRAEWEGP--------VGITLPSVV 84
Cdd:COG1940    1 NPDAGYVIGIDIGGTKIKAALVDLD-GEVL-ARERIPTPAGAGPEAVLEAIAELIEELLAEAGisrgrilgIGIGVPGPV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  85 --KDRVALTAANIdPSWVGADTGELFDRHLpGREVTVLNDADAAGLAEVAHGNPvAGAGSVIFLTFGTGIGSAMLLDGQL 162
Cdd:COG1940   79 dpETGVVLNAPNL-PGWRGVPLAELLEERL-GLPVFVENDANAAALAEAWFGAG-RGADNVVYLTLGTGIGGGIVINGKL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174 163 FPNT-----ELGHLVIDGQEA----------EWTAS-SAVKER-------EELSFKKWAKRVNA-------VLTEYER-- 210
Cdd:COG1940  156 LRGAngnagEIGHMPVDPDGPlcgcgnrgclETYASgPALLRRarelggaEKLTAEELFAAARAgdplaleVLDEAARyl 235

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 529145174 211 ---------LFYPDAFIVGGGISRDHEKWVPRL------------DLRTPVHAAQLRNRAGIVGAAMAV 258
Cdd:COG1940  236 giglanlinLLDPEVIVLGGGVSAAGDLLLEPIrealakyalppaREDPRIVPASLGDDAGLLGAAALA 304
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 21-255 4.23e-20

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 87.01  E-value: 4.23e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174   21 GVDVGGSGIKGAIVDLTtGEfIGDRIKILTPQPATPDAVAETIAELLDRAE----WEGPVGITLPSVV--KDRVALTAAN 94
Cdd:pfam00480   2 GIDIGGTKIAAALFDEE-GE-ILARERVPTPTTTTEETLVDAIAFFVDSAQrkfgELIAVGIGSPGLIspKYGYITNTPN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174   95 IDpsWVGADTGELFDRHLpGREVTVLNDADAAGLAEVAHGNPvAGAGSVIFLTFGTGIGSAMLLDGQLF-----PNTELG 169
Cdd:pfam00480  80 IG--WDNFDLVEKLEERF-NVPVFFENDANAAALAEAVFGAS-KDVQNVIYVTVGTGVGGGVISNGKLFtgrngVAGEIG 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  170 HLVIDGQEA----------EWTASSAVKER------EELSFKKWAKRVN-------AVLTEYER-----------LFYPD 215
Cdd:pfam00480 156 HIQLDPNGPkcgcgnhgclETIASGRALEKryqqkgEDLEGKDIIVLAEqgdevaeEAVERLARylakaianlinLFDPQ 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 529145174  216 AFIVGGGISRDH----------EKWVPRLDLRTPVH--AAQLRNRAGIVGAA 255
Cdd:pfam00480 236 AIVLGGGVSNADglleairslvKKYLNGYLPVPPVIivAASLGDNAGALGAA 287
PRK09557 PRK09557
fructokinase; Reviewed
 21-161 5.36e-08

fructokinase; Reviewed


Pssm-ID: 236565 [Multi-domain]  Cd Length: 301  Bit Score: 52.72  E-value: 5.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  21 GVDVGGSGIKGAIVDLTTGEFIgdRIKILTPQPATPDAVaETIAELLDRAEWE----GPVGITLPSVVKDRVALTAaNID 96
Cdd:PRK09557   4 GIDLGGTKIEVIALDDAGEELF--RKRLPTPRDDYQQTI-EAIATLVDMAEQAtgqrGTVGVGIPGSISPYTGLVK-NAN 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 529145174  97 PSWVgadTGELFDRHLP---GREVTVLNDADAAGLAEVAHGnPVAGAGSVIFLTFGTGIGSAMLLDGQ 161
Cdd:PRK09557  80 STWL---NGQPLDKDLSarlNREVRLANDANCLAVSEAVDG-AAAGKQTVFAVIIGTGCGAGVAINGR 143
 
Name Accession Description Interval E-value
ASKHA_NBD_ROK_PPGK cd24058
nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK ...
 20-257 5.26e-123

nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK (EC 2.7.1.63/EC 2.7.1.2), also called poly(P)/ATP-glucomannokinase (GMK), poly(P) glucokinase, ATP-dependent glucokinase, or polyphosphate--glucose phosphotransferase, catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. Polyphosphate, rather than ATP, seems to be the major phosphate donor for the enzyme in Mycobacterium tuberculosis. GTP, UTP and CTP can replace ATP as phosphoryl donor. PPGK belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this family lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466908 [Multi-domain]  Cd Length: 239  Bit Score: 349.95  E-value: 5.26e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  20 FGVDVGGSGIKGAIVDLTTGEFIGDRIKILTPQPATPDAVAETIAELLDRAEWEGPVGITLPSVVKDRVALTAANIDPSW 99
Cdd:cd24058    2 LGIDIGGSGIKGAIVDTDTGELLSERIRIPTPQPATPEAVADVVAELVAHFPWFGPVGVGFPGVVRRGVVRTAANLDKSW 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174 100 VGADTGELFDRHLpGREVTVLNDADAAGLAEVAHGNPVAGAGSVIFLTFGTGIGSAMLLDGQLFPNTELGHLVIDGQEAE 179
Cdd:cd24058   82 IGFDAAKLLSKRL-GRPVRVLNDADAAGLAEMKGGAGKGEKGVVLVLTLGTGIGSALFVDGHLVPNTELGHLEIRGKDAE 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 529145174 180 WTASSAVKEREELSFKKWAKRVNAVLTEYERLFYPDAFIVGGGISRDHEKWVPRLDLRTPVHAAQLRNRAGIVGAAMA 257
Cdd:cd24058  161 ERASLGVRAREDLGWKRWAKRVNKYLQYLERLFNPDLFIIGGGNSKKADKFLPLLDVKTPVVPAVLRNDAGIVGAALL 238
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 13-258 1.19e-34

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 126.55  E-value: 1.19e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  13 NDTATTAFGVDVGGSGIKGAIVDLTtGEFIgDRIKILTPQPATPDAVAETIAELLDRAEWEGP--------VGITLPSVV 84
Cdd:COG1940    1 NPDAGYVIGIDIGGTKIKAALVDLD-GEVL-ARERIPTPAGAGPEAVLEAIAELIEELLAEAGisrgrilgIGIGVPGPV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  85 --KDRVALTAANIdPSWVGADTGELFDRHLpGREVTVLNDADAAGLAEVAHGNPvAGAGSVIFLTFGTGIGSAMLLDGQL 162
Cdd:COG1940   79 dpETGVVLNAPNL-PGWRGVPLAELLEERL-GLPVFVENDANAAALAEAWFGAG-RGADNVVYLTLGTGIGGGIVINGKL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174 163 FPNT-----ELGHLVIDGQEA----------EWTAS-SAVKER-------EELSFKKWAKRVNA-------VLTEYER-- 210
Cdd:COG1940  156 LRGAngnagEIGHMPVDPDGPlcgcgnrgclETYASgPALLRRarelggaEKLTAEELFAAARAgdplaleVLDEAARyl 235

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 529145174 211 ---------LFYPDAFIVGGGISRDHEKWVPRL------------DLRTPVHAAQLRNRAGIVGAAMAV 258
Cdd:COG1940  236 giglanlinLLDPEVIVLGGGVSAAGDLLLEPIrealakyalppaREDPRIVPASLGDDAGLLGAAALA 304
ASKHA_ATPase_ROK cd23763
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family ...
 21-256 1.09e-33

ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family corresponds to a group of proteins including sugar kinases, transcriptional repressors, and yet uncharacterized open reading frames. ROK family sugar kinases phosphorylate a range of structurally distinct hexoses including the key carbon source D-glucose, various glucose epimers, and several acetylated hexosamines. The sugar kinases include N-acetyl-D-glucosamine kinase (NAGK; EC 2.7.1.59), polyphosphate glucokinase (PPGK; EC 2.7.1.63/EC 2.7.1.2), glucokinase (GLK; EC 2.7.1.2), fructokinase (FRK; EC 2.7.1.4), hexokinase (HK; EC 2.7.1.1), D-allose kinase (AlsK; EC 2.7.1.55), bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE; EC 3.2.1.183/EC 2.7.1.60), N-acetylmannosamine kinase (NanK; EC 2.7.1.60), beta-glucoside kinase (BglK; EC 2.7.1.85), and N-acetylglucosamine kinase (EC 2.7.1.59). The family also contains the repressor proteins, such as N-acetylglucosamine repressor (NagC), xylose repressor (XylR), cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and protein Mlc. ROK kinases harbor a conserved N-terminal ATP binding motif of sequence DxGxT, while ROK repressors possess a N-terminal extension that contains a canonical helix-turn-helix DNA binding motif. The ROK family proteins belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466849 [Multi-domain]  Cd Length: 239  Bit Score: 122.19  E-value: 1.09e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  21 GVDVGGSGIKGAIVDLTtGEfIGDRIKILTPQPATPDAVAETIAELLDRAEWEGP-------VGITLPSVV--KDRVALT 91
Cdd:cd23763    2 GIDIGGTKIRAALVDLD-GE-ILARERVPTPAEEGPEAVLDRIAELIEELLAEAGvrerilgIGIGVPGPVdpETGIVLF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  92 AANIdPSWVGADTGELFDRHLpGREVTVLNDADAAGLAEVAHGNpVAGAGSVIFLTFGTGIGSAMLLDGQLFPNT----- 166
Cdd:cd23763   80 APNL-PWWKNVPLRELLEERL-GLPVVVENDANAAALGEAWFGA-GRGVRNFVYITLGTGIGGGIIIDGKLYRGAngaag 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174 167 ELGHLVIdgqeaewtassavkereelsFKKWAKRVNAVLTEYERLFYPDAFIVGGGISRDHEKWVPRL------------ 234
Cdd:cd23763  157 EIGHITV--------------------LEEAARYLGIGLANLINLLNPELIVLGGGVAEAGDLLLEPIreavrrralppl 216

                        250       260
                 ....*....|....*....|..
gi 529145174 235 DLRTPVHAAQLRNRAGIVGAAM 256
Cdd:cd23763  217 RRRVRIVPSELGDDAGLLGAAA 238
ASKHA_NBD_ROK_FnNanK-like cd24068
nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and ...
 21-255 1.86e-31

nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and similar proteins; The family includes Fusobacterium nucleatum N-acetylmannosamine kinase (NanK; EC 2.7.1.60) and beta-glucoside kinase (BglK; EC 2.7.1.85) from Klebsiella pneumoniae and Listeria innocua. NanK catalyzes the second step of the sialic acid catabolic pathway, transferring a phosphate group from adenosine 5'-triphosphate to the C6 position of N-acetylmannosamine to generate N-acetylmannosamine 6-phosphate. Unlike other NanK enzymes and ROK family members, F. nucleatum NanK does not have a conserved zinc-binding site. BglK catalyzes the ATP-dependent phosphorylation of cellobiose to produce cellobiose-6'-P. It may have a dual role of kinase and transcriptional regulator of the cellobiose-PTS operon. The subfamily belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466918 [Multi-domain]  Cd Length: 294  Bit Score: 117.66  E-value: 1.86e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  21 GVDVGGSGIKGAIVDlTTGEFIgDRIKILTP----QPATPDAVAETIAELLDRAEWEGpVGITLPSVV---KDRVALTAA 93
Cdd:cd24068    4 GIDIGGTKIKYGLVD-ADGEIL-EKDSVPTPaskgGDAILERLLEIIAELKEKYDIEG-IGISSAGQVdpkTGEVIYATD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  94 NIdPSWVGADTGELFDRHLpGREVTVLNDADAAGLAEVAHGNpVAGAGSVIFLTFGTGIGSAMLLDGQLFPNT-----EL 168
Cdd:cd24068   81 NL-PGWTGTNLKEELEERF-GLPVAVENDVNCAALAEKWLGA-AKGLDDFLCLTLGTGIGGAIILDGRLYRGAngsagEL 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174 169 GHLVIDGQEAEWT----------AS--------SAVKEREELS----FKKWAKRVNAVLTEYER--------------LF 212
Cdd:cd24068  158 GHMVVDPGGRPCCcggkgcleqyASgtalvrrvAEALGEPGIDgreiFDLADAGDPLAKEVVEEfaedlatglanlvhIF 237

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 529145174 213 YPDAFIVGGGISRDHEKWVPRL------------DLRTPVHAAQLRNRAGIVGAA 255
Cdd:cd24068  238 DPEVIVIGGGISAQGELFLEELreelrkllmpplLDATKIEPAKLGNDAGLLGAA 292
ASKHA_NBD_ROK-like cd24152
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This ...
 23-256 7.17e-21

nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This subfamily is composed of uncharacterized proteins belonging to the the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466988 [Multi-domain]  Cd Length: 286  Bit Score: 89.16  E-value: 7.17e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  23 DVGGSGIKGAIVDlTTGEfIGDRIKILTPQpATPDAVAETIAELLDR--AEWEGpVGITLPSVV--KDRVALTAA----N 94
Cdd:cd24152    6 DIGGTFIKYALVD-ENGN-IIKKGKIPTPK-DSLEEFLDYIKKIIKRydEEIDG-IAISAPGVIdpETGIIYGGGalpyL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  95 IDPSWVGadtgELFDR-HLPgreVTVLNDADAAGLAEVAHGNpVAGAGSVIFLTFGTGIGSAMLLDGQLF---PNT--EL 168
Cdd:cd24152   82 KGFNLKE----ELEERcNLP---VSIENDAKCAALAELWLGS-LKGIKNGAVIVLGTGIGGAIIIDGKLYrgsHFFagEF 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174 169 GHLVIDGQEAE-------WTASSAVKEREELS----------FKKWAK---RVNAVLTEYER-----------LFYPDAF 217
Cdd:cd24152  154 SYLLTDDDDKDllffsglASMFGLVKRYNKAKglepldgeeiFEKYAKgdeAAKKILDEYIRnlakliyniqyILDPEVI 233

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 529145174 218 IVGGGIS-------------RDHEKWVPRLDLRTPVHAAQLRNRAGIVGAAM 256
Cdd:cd24152  234 VIGGGISeqplfiedlkkevNEILANRPGSIPKPEIKACKFGNDANLLGALY 285
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 21-255 4.23e-20

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 87.01  E-value: 4.23e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174   21 GVDVGGSGIKGAIVDLTtGEfIGDRIKILTPQPATPDAVAETIAELLDRAE----WEGPVGITLPSVV--KDRVALTAAN 94
Cdd:pfam00480   2 GIDIGGTKIAAALFDEE-GE-ILARERVPTPTTTTEETLVDAIAFFVDSAQrkfgELIAVGIGSPGLIspKYGYITNTPN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174   95 IDpsWVGADTGELFDRHLpGREVTVLNDADAAGLAEVAHGNPvAGAGSVIFLTFGTGIGSAMLLDGQLF-----PNTELG 169
Cdd:pfam00480  80 IG--WDNFDLVEKLEERF-NVPVFFENDANAAALAEAVFGAS-KDVQNVIYVTVGTGVGGGVISNGKLFtgrngVAGEIG 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  170 HLVIDGQEA----------EWTASSAVKER------EELSFKKWAKRVN-------AVLTEYER-----------LFYPD 215
Cdd:pfam00480 156 HIQLDPNGPkcgcgnhgclETIASGRALEKryqqkgEDLEGKDIIVLAEqgdevaeEAVERLARylakaianlinLFDPQ 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 529145174  216 AFIVGGGISRDH----------EKWVPRLDLRTPVH--AAQLRNRAGIVGAA 255
Cdd:pfam00480 236 AIVLGGGVSNADglleairslvKKYLNGYLPVPPVIivAASLGDNAGALGAA 287
ASKHA_NBD_ROK_EcNanK-like cd24069
nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar ...
 20-162 1.66e-16

nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar proteins; N-acetylmannosamine kinase (NanK; EC 2.7.1.60), also called ManNAc kinase, or N-acetyl-D-mannosamine kinase, catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P. It has also low level glucokinase activity in vitro. This subfamily also contains Brucella melitensis bifunctional enzyme NanE/NanK (EC 5.1.3.9/EC 2.7.1.60), which also converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466919 [Multi-domain]  Cd Length: 283  Bit Score: 76.94  E-value: 1.66e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  20 FGVDVGGSGIKGAIVDlttGEFIGDRIKILTPQPATPDAVAETIAELLdrAEWEG---PVGITLPSVVKDRVaLTAANID 96
Cdd:cd24069    1 LAIDIGGTKIAAALIG---NGQIIDRRQIPTPRSGTPEALADALASLL--ADYQGqfdRVAVASTGIIRDGV-LTALNPK 74

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 529145174  97 --PSWVGADTGELFDRHLpGREVTVLNDADAAGLAEVAHGnPVAGAGSVIFLTFGTGIGSAMLLDGQL 162
Cdd:cd24069   75 nlGGLSGFPLADALQQLL-GVPVVLLNDAQAAAWGEYQAG-DGEGVGNLVFITVSTGVGGGLVLNGQL 140
ASKHA_NBD_ROK_SgGLK-like cd24061
nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; ...
 19-255 6.28e-15

nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466911 [Multi-domain]  Cd Length: 306  Bit Score: 72.77  E-value: 6.28e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  19 AFGVDVGGSGIKGAIVDlTTGEFIGdriKILTPQPATP----DAVAETIAELLDRAEWEGpVGITLPSVVKD--RVALTA 92
Cdd:cd24061    1 TIGVDIGGTKIAAGVVD-EEGEILA---TERVPTPPTAdgivDAIVEAVEELREGHDVSA-VGVAAAGFVDAdrATVLFA 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  93 ANIDpsWVGADTGELFdRHLPGREVTVLNDADAAGLAEVAHGnPVAGAGSVIFLTFGTGIGSAMLLDGQLFPNT-----E 167
Cdd:cd24061   76 PNIA--WRNEPLKDLL-EARIGLPVVIENDANAAAWAEYRFG-AGRGTDDMVMITVGTGLGGGIVIGGKLLRGAfgiagE 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174 168 LGHLVI----------------------------------DGQEAEWTASSAVKEREE----------------LSFKKW 197
Cdd:cd24061  152 FGHIRVvpdgllcgcgsrgcweqyasgralvryakeaanaTPEGAAVLLADGSVDGITgkhiseaaragdpvalDALREL 231

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 529145174 198 AKRVNAVLTEYERLFYPDAFIVGGGISRD-----------------HEKWVPRLDLRTpvhaAQLRNRAGIVGAA 255
Cdd:cd24061  232 ARWLGAGLASLAALLDPELFVIGGGVSDAgdllldpireaferwlpGRGWRPIPRLRT----AQLGNDAGLIGAA 302
ASKHA_NBD_ROK_TtHK-like cd24065
nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; ...
 21-257 9.39e-15

nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; HK (EC 2.7.1.1) possesses the ability to transfer an inorganic phosphate group from ATP to a substrate. It catalyzes the ATP-dependent phosphorylation of aldo- and keto-hexose sugars to the hexose-6-phosphate (H6P). Thermus thermophilus HK possesses significant enzymatic activity against glucose and mannose. However, it shows little catalytic capacity for galactose and fructose. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466915 [Multi-domain]  Cd Length: 289  Bit Score: 72.36  E-value: 9.39e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  21 GVDVGGSGIKGAIVDlttGEFIGDRIKILTPQPATpDAVAETIAELLDRAEWEGP----VGITLPSVV--KDRVALTAAN 94
Cdd:cd24065    4 GLDLGGTKIAAGVVD---GGRILSRLVVPTPREGG-EAVLDALARAVEALQAEAPgveaVGLGVPGPLdfRRGRVRFAPN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  95 IdPSWVGADTGELFDRHLpGREVTVLNDADAAGLAEvAHGNPVAGAGSVIFLTFGTGIGSAMLLDGQLFPNT-----ELG 169
Cdd:cd24065   80 I-PGLTDFPIRRGLAERL-GLPVVLENDANAAALAE-HHYGAARGTESSVYVTISTGIGGGLVLGGRVLRGRhgqagEIG 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174 170 HLVI--------DGQEA--EWTASSAVKERE------------ELsFKKW------AKRV--NAV------LTEYERLFY 213
Cdd:cd24065  157 HTTVlpggpmcgCGLVGclEALASGRALARDasfaygrpmstaEL-FELAqqgepkALRIveQAAahlgigLANLQKALD 235

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 529145174 214 PDAFIVGGGIS---------------RDHEKWVPrldlrTPVHAAQLRNRAGIVGAAMA 257
Cdd:cd24065  236 PEVFVLGGGVAqvgdyyllpvqeaarRYTEGWHA-----PPLRLAHLGTDAGVIGAALA 289
ASKHA_ATPase_ROK_BsXylR-like cd24076
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This ...
 21-174 2.94e-14

ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Bacillus subtilis xylose repressor (BsXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. BsXylR acts as transcriptional repressor of xylose-utilizing enzymes.


Pssm-ID: 466926 [Multi-domain]  Cd Length: 303  Bit Score: 71.06  E-value: 2.94e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  21 GVDVGGSGIKGAIVDLTtGEFIGdRIKILTPQPATPDAVAETIAELLDRAEWEGP--------VGITLPSVVKDR--VAL 90
Cdd:cd24076    5 GVELGVDYITVVVTDLA-GEVLW-RREVPLPASDDPDEVLAQLAALIREALAAAPdsplgilgIGVGVPGLVDSEdgVVL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  91 TAANIDpsWVGADTGELFDRHLpGREVTVLNDADAAGLAEVAHGnPVAGAGSVIFLTFGTGIGSAMLLDGQLFPNT---- 166
Cdd:cd24076   83 LAPNLG--WRDVPLRDLLEEAL-GVPVFVDNEANAAALAEKRFG-AGRGVSDLVYLSAGVGIGAGIILDGELYRGAsgfa 158


                 ....*....
gi 529145174 167 -ELGHLVID 174
Cdd:cd24076  159 gEIGHMTVD 167
ASKHA_NBD_ROK_NAGK cd24057
nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; ...
 19-171 3.82e-14

nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; NAGK (EC 2.7.1.59), also called GlcNAc kinase, catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466907 [Multi-domain]  Cd Length: 298  Bit Score: 70.72  E-value: 3.82e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  19 AFGVDVGGSGIKGAIVDlTTGEfIGDRIKILTPQ---PATPDAVAETIAELLDRAEWEGPVGITLPSVVKDRV-ALTAAN 94
Cdd:cd24057    2 YYGFDIGGTKIEFAVFD-EALQ-LVWTKRVPTPTddyAAFLAAIAELVAEADARFGVKGPVGIGIPGVIDPEDgTLITAN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  95 IdPSWVG----ADTGELFdrhlpGREVTVLNDADAAGLAEvAHGNPVAGAGSVIFLTFGTGIGSAMLLDGQLFPNT---- 166
Cdd:cd24057   80 I-PAAKGrplrADLSARL-----GRPVRIDNDANCFALSE-AWDGAGRGYPSVFGLILGTGVGGGLVVNGRLVGGRsgia 152


                 ....*.
gi 529145174 167 -ELGHL 171
Cdd:cd24057  153 gEWGHG 158
ASKHA_NBD_ROK_AlsK cd24070
nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1. ...
 21-258 1.22e-12

nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1.55), also called allokinase, catalyzes the phosphorylation of D-allose to D-allose 6-phosphate. It has also low level glucokinase activity in vitro. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466920 [Multi-domain]  Cd Length: 293  Bit Score: 66.42  E-value: 1.22e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  21 GVDVGGSGIKGAIVDlTTGEFIGDRIKILTPQPATPDAVaETIAELLDR--AEWEGP---VGITLPSVV-KDR-VALTAA 93
Cdd:cd24070    5 GIDIGGTNIRIGLVD-EDGKLLDFEKVPSKDLLRAGDPV-EVLADLIREyiEEAGLKpaaIVIGVPGTVdKDRrTVISTP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  94 NIdPSWVGADTGELFDRHLpGREVTVLNDADAAGLAEVAHGNpVAGAGSVIFLTFGTGIGSAMLLDGQLFPNT-----EL 168
Cdd:cd24070   83 NI-PGLDGVNLADILENKL-GIPVILERDVNLLLLYDMRAGN-LDDEGVVLGFYIGTGIGNAILINGKPLRGKngvagEL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174 169 GHLVIDGQE--------------------AEWTASSAVKEREELSFKK--WAKRV--------NAVLTEYErLFYPDAFI 218
Cdd:cd24070  160 GHIPVYGNGkpcgcgntgcletyasgralEEIAEEHYPDTPILDIFVDhgDEPELdefvedlaLAIATEIN-ILDPDAVI 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 529145174 219 VGGGIS-------RDHEKWVpRLDLRTPVHAAQLR-------NRAGIVGAAMAV 258
Cdd:cd24070  239 LGGGVIdmkgfprETLEEYI-RKHLRKPYPADNLKiiyaelgPEAGVIGAAIYA 291
ASKHA_NBD_ROK_BsGLK-like cd24062
nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; ...
 21-255 3.48e-12

nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466912 [Multi-domain]  Cd Length: 311  Bit Score: 65.00  E-value: 3.48e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  21 GVDVGGSGIKGAIVDlTTGEFIgDRIKILTPQ----PATPDAVAETIAELLDRA--EWEGPVGITL----PSVVKDRVAL 90
Cdd:cd24062    4 GIDVGGTTIKMAFLT-QEGEIV-QKWEIPTNKleggENIITDIAESIQQLLEELgySKEDLIGIGVgvpgPVDVETGTVE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  91 TAANIdpSWVGADTGELFDRhLPGREVTVLNDADAAGLAEVAHGnpvAGAG--SVIFLTFGTGIGSAMLLDGQLFPNT-- 166
Cdd:cd24062   82 VAVNL--GWKNFPLKDKLEA-LTGIPVVIDNDANAAALGEMWKG---AGQGakDLVFITLGTGVGGGVIANGKIVHGAng 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174 167 ---ELGHLVIDGQEA-----------EWTASS---------AVKEREELSFKKWAKRVNAV----------------LTE 207
Cdd:cd24062  156 aagEIGHITVNPEGGapcncgktgclETVASAtgivriareELEEGKGSSALRILALGGELtakdvfeaakagdelaLAV 235

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 529145174 208 YER--------------LFYPDAFIVGGGISRDHEKWV------------PRLDLRTPVHAAQLRNRAGIVGAA 255
Cdd:cd24062  236 VDTvarylglalanlanTLNPEKIVIGGGVSAAGEFLLspvkeyfdrftfPRVRQDTEIVLATLGNDAGVIGAA 309
ASKHA_NBD_ROK_ApGLK-like cd24063
nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; ...
 18-256 9.41e-12

nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466913 [Multi-domain]  Cd Length: 308  Bit Score: 63.90  E-value: 9.41e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  18 TAFGVDVGGSGIKGAIVDLttgefiGDRI--KILTPQPATPDA------VAETIAELLDRAEWEGPVGITL----PSVVK 85
Cdd:cd24063    1 YYVAVDIGGTWIRAGLVDE------DGRIllKIRQPTPKTGDPgtvseqVLGLIETLLSKAGKDSIEGIGVssagPLDLR 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  86 DRVALTAANIdPSWVGADTGELFDRhlPGREVTVLNDADAAGLAEVAHGnpvAGAG--SVIFLTFGTGIGSAMLLDGQLF 163
Cdd:cd24063   75 KGTIVNSPNI-KGKEIPLVEPLKEE--FNIPVALLNDAVAAALGEHLFG---AGRGtsNLVYITISTGIGGGVIVDGRLL 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174 164 PN-----TELGHLVID---------GQEAEWTA---SSAVKEReelsFKKWAKRVNAVLTEYER---------------- 210
Cdd:cd24063  149 LGkngnaAEVGHLVVDtesglkcgcGGYGHWEAfasGRGIPRF----AREWAEGFSSRTSLKLRnpggegitakevfsaa 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174 211 ---------------------------LFYPDAFIVGGGISRDHEKWVPRLDLRTPVHAA----------QLRNRAGIVG 253
Cdd:cd24063  225 rkgdplalkiieklaryngrgianvinAYDPELIVIGGSVFNNNKDILDPLIEYLEKNPAiskgpeivlsELGDDVGLIG 304


                 ...
gi 529145174 254 AAM 256
Cdd:cd24063  305 ALA 307
ASKHA_NBD_ROK_TM1224-like cd24059
nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and ...
 19-174 3.40e-11

nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to N-acetylglucosamine kinase (Tm1224; EC 2.7.1.59) from Thermotoga maritima, which belongs to kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Tm1224 lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466909 [Multi-domain]  Cd Length: 305  Bit Score: 62.22  E-value: 3.40e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  19 AFGVDVGGSGIKGAIVDLTtGEFIGdRIKILTPQPATPDAVAETIAELLDR-AEWEGP------VGITLPS--VVKDRVA 89
Cdd:cd24059    3 VIGVEIGRDLLSAVLCDLS-GNILA-REKYPLDEKENPEEVLEKLYELIDRlLEKENIkskilgIGIGAPGplDVEKGII 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  90 LTAANIdPSWVGADTGELFDRHLpGREVTVLNDADAAGLAEVAHGNPVaGAGSVIFLTFGTGIGSAMLLDGQLFPN---- 165
Cdd:cd24059   81 LNPPNF-PGWENIPLVELLEEKF-GIPVYLDNDANAAALAEKWYGKGK-NYDNFIYILADEGIGAGIIINGKLYRGvdgy 157

                        170
                 ....*....|
gi 529145174 166 -TELGHLVID 174
Cdd:cd24059  158 aGEIGHTSID 167
ASKHA_NBD_ROK_TmGLK-like cd24064
nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; ...
 19-174 2.62e-10

nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466914 [Multi-domain]  Cd Length: 301  Bit Score: 59.43  E-value: 2.62e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  19 AFGVDVGGSGIKGAIVDLTtgefiGDRIKILTPQPATPDA-------VAETIAELLDRAEWEGpVGITLPSVV--KDRVA 89
Cdd:cd24064    1 VIGIDLGGTDTKIGIVDEN-----GDILKKKTIDTKVENGkedvinrIAETVNELIEEMELLG-IGIGSPGSIdrENGIV 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  90 LTAANIdPSWVGADTGELFDRHLpGREVTVLNDADAAGLAEVAHGNpVAGAGSVIFLTFGTGIGSAMLLDGQLFPN---- 165
Cdd:cd24064   75 RFSPNF-PDWRNFPLVPLIEERT-GIKVFLENDANAFALGEWWFGN-AKGSNHIIGLTLGTGVGSGVICHGQLLTGydgi 151

                        170
                 ....*....|
gi 529145174 166 -TELGHLVID 174
Cdd:cd24064  152 aAELGHVIVE 161
ASKHA_NBD_ROK_EcFRK-like cd24066
nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; ...
 21-255 1.73e-09

nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; Escherichia coli FRK (EC 2.7.1.4), also called D-fructose kinase, manno(fructo)kinase, or MAK, catalyzes the phosphorylation of fructose to fructose-6-phosphate. It has also low level glucokinase activity in vitro. It is not able to phosphorylate D-ribose, D-mannitol, D-sorbitol, inositol, and L-threonine. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466916 [Multi-domain]  Cd Length: 294  Bit Score: 57.21  E-value: 1.73e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  21 GVDVGGSGIKGAIVDLTTGEFIgdRIKILTPQPATpDAVAETIAELLDRAEWE----GPVGITLPSVVKDRVALtAANID 96
Cdd:cd24066    3 GIDLGGTKIEGIALDRAGRELL--RRRVPTPRGDY-EATLDAIADLVEEAEEElgapATVGIGTPGSISPRTGL-VKNAN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  97 PSW-----VGADTGELFdrhlpGREVTVLNDADAAGLAEVAHGnPVAGAGSVIFLTFGTGIGSAMLLDGQLFPNT----- 166
Cdd:cd24066   79 STWlngkpLKADLEARL-----GRPVRIENDANCFALSEATDG-AGAGAGVVFGVILGTGVGGGIVVNGRVLTGAngiag 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174 167 ELGHLVID---------------------------GQEAEWTASSAVKER-EELSFKKWAKRVNAVLT--EYERLFY--- 213
Cdd:cd24066  153 EWGHNPLPwpdedelpgppcycgkrgcvetflsgpALERDYARLTGKTLSaEEIVALARAGDAAAVATldRFLDRLGral 232

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174 214 --------PDAFIVGGGISR-DH---------EKWVPRLDLRTPVHAAQLRNRAGIVGAA 255
Cdd:cd24066  233 anvinildPDVIVLGGGLSNiDElytegpaalARYVFSDEVETPIVKNKHGDSSGVRGAA 292
ASKHA_NBD_ROK_GNE cd24060
nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase ...
 18-174 1.20e-08

nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) and similar proteins; GNE (EC 3.2.1.183/EC 2.7.1.60), also called UDP-GlcNAc-2-epimerase/ManAc kinase, is a bi-functional enzyme that plays a key role in sialic acid biosynthesis. It regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It plays an essential role in early development and required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. GNE is the only human protein that contains a kinase domain belonging to the ROK (repressor, ORF, kinase) family. Mutations of the GNE protein cause sialurea or autosomal recessive inclusion body myopathy/Nonaka myopathy.


Pssm-ID: 466910 [Multi-domain]  Cd Length: 305  Bit Score: 54.73  E-value: 1.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  18 TAFGVDVGGSGIKGAIVDLTtgefiGDRIKILT-PQPATPDAVAETIAELLDRAEWE--------GPVGITLPSVV--KD 86
Cdd:cd24060    1 SALAVDLGGTNLRVAIVSMK-----GEIVKKYTqPNPKTYEERIDLILQMCVEAASEavklncriLGVGISTGGRVnpRE 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  87 RVALTAANIDPSWVGADTGELFDRHLpGREVTVLNDADAAGLAEVAHGnpvAGAGSVIFLTF--GTGIGSAMLLDGQL-- 162
Cdd:cd24060   76 GIVLHSTKLIQEWSSVDLRTPISDAL-HLPVWVDNDGNCAALAERKFG---HGKGVENFVTVitGTGIGGGIILNHELih 151

                        170
                 ....*....|....*
gi 529145174 163 ---FPNTELGHLVID 174
Cdd:cd24060  152 gssFCAAELGHIVVS 166
ASKHA_ATPase_ROK_CYANR cd24073
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; ...
 19-174 4.24e-08

ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; CYANR acts as transcriptional repressor of cyclobis-(1-6)-alpha-nigerosyl (CNN) degrading enzymes. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466923 [Multi-domain]  Cd Length: 304  Bit Score: 52.94  E-value: 4.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  19 AFGVDVGGSGIKGAIVDLTTGEFIGDRIKIltpQPATPDAVAETIAELLDRAEWEGP--------VGITLPSVV--KDRV 88
Cdd:cd24073    3 VVGVKLTEDRITAVLTDLRGNVLASHTLPL---DSGDPEAVAEAIAEAVAELLAQAGlspdrllgIGVGLPGLVdaETGI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  89 ALTAANIDpsWVGADTGELFDRHLpGREVTVLNDADAAGLAEVAHGNPVaGAGSVIFLTFGTGIGSAMLLDGQLFPNT-- 166
Cdd:cd24073   80 CRWSPLLG--WRDVPLAELLEERL-GLPVYVENDVNALALAEHWFGAGR-GLDNFAVVTIGRGIGCGLVVDGRLYRGAhg 155

                        170
                 ....*....|.
gi 529145174 167 ---ELGHLVID 174
Cdd:cd24073  156 gagEIGHTTVD 166
PRK09557 PRK09557
fructokinase; Reviewed
 21-161 5.36e-08

fructokinase; Reviewed


Pssm-ID: 236565 [Multi-domain]  Cd Length: 301  Bit Score: 52.72  E-value: 5.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  21 GVDVGGSGIKGAIVDLTTGEFIgdRIKILTPQPATPDAVaETIAELLDRAEWE----GPVGITLPSVVKDRVALTAaNID 96
Cdd:PRK09557   4 GIDLGGTKIEVIALDDAGEELF--RKRLPTPRDDYQQTI-EAIATLVDMAEQAtgqrGTVGVGIPGSISPYTGLVK-NAN 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 529145174  97 PSWVgadTGELFDRHLP---GREVTVLNDADAAGLAEVAHGnPVAGAGSVIFLTFGTGIGSAMLLDGQ 161
Cdd:PRK09557  80 STWL---NGQPLDKDLSarlNREVRLANDANCLAVSEAVDG-AAAGKQTVFAVIIGTGCGAGVAINGR 143
PRK05082 PRK05082
N-acetylmannosamine kinase; Provisional
 22-171 8.28e-08

N-acetylmannosamine kinase; Provisional


Pssm-ID: 235338 [Multi-domain]  Cd Length: 291  Bit Score: 52.22  E-value: 8.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  22 VDVGGSGIKGAIVDlTTGEFIGdRIKILTPQPATPDAVAETIAELLdrAEWEGPVgitlpsvvkDRVA-----------L 90
Cdd:PRK05082   6 IDIGGTKIAAALVG-EDGQIRQ-RRQIPTPASQTPEALRQALSALV--SPLQAQA---------DRVAvastgiindgiL 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  91 TAANIDpswvgaDTGELFD-------RHLPGREVTVLNDADAAGLAE-VAHGNPVagaGSVIFLTFGTGIGSAMLLDGQL 162
Cdd:PRK05082  73 TALNPH------NLGGLLHfplvqtlEQLTDLPTIALNDAQAAAWAEyQALPDDI---RNMVFITVSTGVGGGIVLNGKL 143

                        170
                 ....*....|.
gi 529145174 163 F--PNTELGHL 171
Cdd:PRK05082 144 LtgPGGLAGHI 154
ASKHA_ATPase_ROK_Lmo0178-like cd24071
ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily ...
 19-193 1.23e-07

ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Listeria monocytogenes Lmo0178 protein, which is a predicted transcription repressor belonging to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466921 [Multi-domain]  Cd Length: 312  Bit Score: 51.52  E-value: 1.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  19 AFGVDVGGSGIKGAIVDLTtGEFIgDRIKILTPQPATP----DAVAETIAELLDRAEWEGP---VGITLPSVVKDRVALT 91
Cdd:cd24071    3 IIGVKIEEGYLVLALTDLK-GKIL-EKTRIPFDHETDPekviELIAENIKKLIKNKHVEKKllgIGIAVSGLVDSKKGIV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  92 AANIDPSWVGADTGELFDRHLpGREVTVLNDADAAGLAEVAHGnpvAGAGSVIFL--TFGTGIGSAMLLDGQLFPNT--- 166
Cdd:cd24071   81 IRSTILGWENVELKKILKEKF-KIPVFIDNDVNSFALAELWKG---KGKGYSNFIcvTVGAGIGSSLVIDGKLYTGNfgg 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 529145174 167 --ELGHLVID--------GQ----EAEWTASSAVKEREELS 193
Cdd:cd24071  157 agEIGHMTIQpdgrkcycGQkgclEAYASFEALVNEIKELT 197
PRK13310 PRK13310
N-acetyl-D-glucosamine kinase; Provisional
 20-171 3.15e-07

N-acetyl-D-glucosamine kinase; Provisional


Pssm-ID: 183967 [Multi-domain]  Cd Length: 303  Bit Score: 50.37  E-value: 3.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  20 FGVDVGGSGIKgaivdltTGEFIGDRIKILTPQPATP----DAVAETIAELLDRAE----WEGPVGITLPSVVK-DRVAL 90
Cdd:PRK13310   3 YGFDIGGTKIE-------LGVFNEKLELQWEERVPTPrdsyDAFLDAVCELVAEADqrfgCKGSVGIGIPGMPEtEDGTL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  91 TAANIdPSWVG----ADTGELFdrhlpGREVTVLNDADAAGLAEvAHGNPVAGAGSVIFLTFGTGIGSAMLLDGQLFPNT 166
Cdd:PRK13310  76 YAANV-PAASGkplrADLSARL-----GRDVRLDNDANCFALSE-AWDDEFTQYPLVMGLILGTGVGGGLVFNGKPISGR 148

                        170
                 ....*....|
gi 529145174 167 -----ELGHL 171
Cdd:PRK13310 149 syitgEFGHM 158
ASKHA_ATPase_ROK_YphH-like cd24072
ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily ...
 21-170 1.44e-06

ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Escherichia coli protein YphH that belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466922 [Multi-domain]  Cd Length: 308  Bit Score: 48.57  E-value: 1.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  21 GVDVGGSGIKGAIVDlTTGEFIGDRIKILTpQPATPDAVAETIAELLDRA--EWEGP---VGITLPSVVKDR--VALTAA 93
Cdd:cd24072    5 GIVVSPNSLRAQVGN-ACGELLGEFEYRVI-TLETPEALIDEIIDCIDRLlkLWKDRvkgIALAIQGLVDSHkgVSLWSP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  94 NIdpSWVGADTGELFDRHLpGREVTVLNDADAAGLAEVAHGNPVAGAGSVIFLtFGTGIGSAMLLDGQLFPNT-----EL 168
Cdd:cd24072   83 GA--PWRNIEIKYLLEERY-GIPVFVENDCNMLALAEKWQGELRQSRDFCVIN-LDYGIGSAIVIDNKLYIGAssgsgEI 158


                 ..
gi 529145174 169 GH 170
Cdd:cd24072  159 GH 160
ASKHA_NBD_HK cd24000
nucleotide-binding domain (NBD) of the hexokinase (HK) domain family; Hexokinase (EC 2.7.1.1) ...
 22-170 5.89e-06

nucleotide-binding domain (NBD) of the hexokinase (HK) domain family; Hexokinase (EC 2.7.1.1) possesses the ability to transfer an inorganic phosphate group from ATP to a substrate. It catalyzes the ATP-dependent phosphorylation of aldo- and keto-hexose sugars to the hexose-6-phosphate (H6P). It can catalyze this reaction on glucose, fructose, sorbitol and glucosamine, and as such is the first step in a number of metabolic pathways. Hexokinase contains two structurally similar domains. Some members of the family have two copies of each of these domains. Hexokinases belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466850 [Multi-domain]  Cd Length: 357  Bit Score: 46.88  E-value: 5.89e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  22 VDVGGSGIKGAIVDLT-TGEFIGDRIKILTPQPATP-------DAVAETIAELLDRAEW--EGPVGIT----LPSVVKDR 87
Cdd:cd24000   48 IDLGGTNLRVALVSLDgKGIEVTISKKYEIPDEIKTasaeeffDFIADCIAEFLKENGLkkPLPLGFTfsfpLEQTSLND 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  88 VALTAAN---IDPSWVGADTGELF-----DRHLPGREVTVLNDADAAGLAEVAHGNPVAGAgsvifLTFGTGIGSAMLLD 159
Cdd:cd24000  128 GKLLSWTkgfKIPGVEGKDVGELLndalkKRGLPVKVVAVLNDTVATLLAGAYKDPDCRIG-----LILGTGTNAAYLEP 202

                        170
                 ....*....|....*....
gi 529145174 160 GQLFP--------NTELGH 170
Cdd:cd24000  203 TSNILlgdggmiiNTEWGN 221
ASKHA_NBD_ROK_BsFRK-like cd24067
nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; ...
 21-170 1.07e-05

nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; Bacillus subtilis FRK (EC 2.7.1.4), also called glucomannan utilization protein E, catalyzes the phosphorylation of fructose to fructose-6-P. It seems to be involved in the degradation of glucomannan. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466917 [Multi-domain]  Cd Length: 285  Bit Score: 45.61  E-value: 1.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  21 GVDVGGSGIKGAIVdlTTGEFIGDRIKILTpqpATPDAVAETIAELLDRAEWE---------GPVGItlpsvvkDRVALT 91
Cdd:cd24067    3 GIEAGGTKFVCAVG--TGDGNIIERTEFPT---TTPEETLQAVIDFFREQEEPidaigiasfGPIDL-------NPTSPT 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  92 AANI----DPSWVGADTGELFDRHLPgreVTVLNDAD--AAGLAEVAHGNPvAGAGSVIFLTFGTGIGSAMLLDGQLFP- 164
Cdd:cd24067   71 YGYItttpKPGWRNFDILGALKRAFP---VPVGFDTDvnAAALAEYRWGAA-KGLDSLAYITVGTGIGVGLVVNGKPVHg 146


                 ....*...
gi 529145174 165 --NTELGH 170
Cdd:cd24067  147 llHPEMGH 154
ASKHA_NBD_MurK-like cd24084
nucleotide-binding domain (NBD) of Clostridium acetobutylicum N-acetylmuramic acid ...
 21-187 9.58e-04

nucleotide-binding domain (NBD) of Clostridium acetobutylicum N-acetylmuramic acid/N-acetylglucosamine kinase (MurK) and similar proteins; The family includes a group of uncharacterized proteins similar to Clostridium acetobutylicum N-acetylmuramic acid/N-acetylglucosamine kinase (MurK; EC 2.7.1.-/EC 2.7.1.59), also known MurNAc/GlcNAc kinase, or murein sugar kinase. It catalyzes the ATP-dependent phosphorylation of both cell wall (peptidoglycan) amino sugars, N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), at the 6-hydroxyl group. Neither the non-N-acetylated forms of the cell wall sugars, i.e., glucosamine and/or muramic acid, nor epimeric hexoses or 1,6-anhydro-MurNAc are substrates for the enzyme. MurK may have a role in the rescue of the murein sugars GlcNAc and MurNAc released from muropeptides during cell wall turnover in C.acetobutylicum.


Pssm-ID: 466934 [Multi-domain]  Cd Length: 302  Bit Score: 40.03  E-value: 9.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  21 GVDVGGSGIKGAIVDL---TTGEFIGDRIKILTpqpATPDAVAETIAELLdrAEWEGPVGITLPSVVKdrVALTAANIDP 97
Cdd:cd24084    5 GIDGGGTKTHLKITDLngnVVGEGFGGSSNLES---NSLETVRENLKELF--QDFYEQLGKSLKECGS--ICLGTAGASH 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  98 SWVGADTGELFDRHLPGREVTVLNDADAAgLAevahGNPVAGAGsvIFLTFGTG-IGSAMLLDGQLFPNTELGHLVIDGQ 176
Cdd:cd24084   78 QGAKETLKDILTELGPDAKIEVVNDAEIA-LA----AGLEGKPG--IVLISGTGsICYGRNTDGETARAGGWGHLLGDEG 150

                        170
                 ....*....|.
gi 529145174 177 EAEWTASSAVK 187
Cdd:cd24084  151 SGYWIAMQALG 161
ASKHA_NBD_GLK cd24008
nucleotide-binding domain (NBD) of glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7. ...
 19-212 1.63e-03

nucleotide-binding domain (NBD) of glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. Glucokinases are mainly found in invertebrates and microorganisms and highly specific for glucose. Glucokinases belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466858 [Multi-domain]  Cd Length: 313  Bit Score: 39.13  E-value: 1.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  19 AFGVDVGGSGIKGAIVDLTTGEFIGDRIKILTPQPAtpDAVAETIAELLDRAEWEGPVGITL----PsVVKDRVALTaaN 94
Cdd:cd24008    1 ILVGDIGGTNARLALADAGDGSGDLLFVRKYPSADF--ASLEDALAAFLAELGAPRPKAACIavagP-VDGGRVRLT--N 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  95 IDPSwvgADTGELFdRHLPGREVTVLNDADAAGLA----------EVAHGNPVAGAGSVIFLTFGTGIGSAmlldgQLFP 164
Cdd:cd24008   76 LDWS---IDAAELR-KALGIGRVRLLNDFEAAAYGlpalgpedllVLYGGGGPLPGGPRAVLGPGTGLGVA-----LLVP 146

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 529145174 165 NTELGHLVIDGqEAEWTASSAVKErEELSFKKWAKRVNAVLTEYERLF 212
Cdd:cd24008  147 DGDGGYVVLPS-EGGHADFAPVTE-EEAELLEFLRKRFGRSVSYEDVL 192
BadF COG2971
BadF-type ATPase, related to human N-acetylglucosamine kinase [Carbohydrate transport and ...
 21-152 5.73e-03

BadF-type ATPase, related to human N-acetylglucosamine kinase [Carbohydrate transport and metabolism];


Pssm-ID: 442210 [Multi-domain]  Cd Length: 298  Bit Score: 37.55  E-value: 5.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  21 GVDVGGSGIKGAIVDLtTGEFIGD-RIKILTPQPATPDAVAETIAELLDRA--EWEGPVGItlpsvvkDRVALTAANIDP 97
Cdd:COG2971    5 GVDGGGTKTRAVLVDA-DGEVLGRgRAGGANPQSVGLEEALASLREALEEAlaAAGDPADI-------EAVGFGLAGAGT 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 529145174  98 SWVGADTGELFDRHLPGREVTVLNDADAAGLAevAHGNP-----VAGAGSVIFLTFGTGI 152
Cdd:COG2971   77 PEDAEALEAALRELFPFARVVVVNDALAALAG--ALGGEdgivvIAGTGSIAAGRDGDGR 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH