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Concise Results
Standard Results
Full Results
phosphoribosylformylglycinamidine synthase [Pseudomonas resinovorans]
Protein Classification
phosphoribosylformylglycinamidine synthase ( domain architecture ID 11480567 )
phosphoribosylformylglycinamidine synthase catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate
List of domain hits
Name
Accession
Description
Interval
E-value
PRK05297
PRK05297 phosphoribosylformylglycinamidine synthase; Provisional
1-1298
0e+00
phosphoribosylformylglycinamidine synthase; Provisional
Pssm-ID: 235394 [Multi-domain]
Cd Length: 1290
Bit Score: 2715.76
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1 MLILRG A PALSAFR HG KLL EQ L TQK V SA V SGL YAE FT HFA EVTGV LS G EE EQV L A RLL K YGP SV pv Q EP S GRLFLV V PR V 80
Cdd:PRK05297 1 MLILRG S PALSAFR LQ KLL AR L QAA V LP V TSI YAE YV HFA DLSAP LS A EE QAK L E RLL T YGP AE -- H EP A GRLFLV T PR P 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 81 GTISPWSSKATDIA R NCGLA K I E R L ERGIAYYV AG A I S DADAE A I AA V LHDRMT QL V LPG L EE A AG LFSH AQ PKPLT V VD 160
Cdd:PRK05297 79 GTISPWSSKATDIA H NCGLA G I R R I ERGIAYYV EA A L S AEQRA A L AA L LHDRMT ES V FAD L DD A EA LFSH HE PKPLT S VD 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 161 I LGGGRAALE K ANVELGLALAEDEIDYLV KS F ND LGRNP H DVELMMFAQANSEHCRHKIFNA S W D IDG QA Q E KSLF G MIK 240
Cdd:PRK05297 159 V LGGGRAALE A ANVELGLALAEDEIDYLV EA F TK LGRNP T DVELMMFAQANSEHCRHKIFNA D W T IDG EE Q P KSLF K MIK 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 241 NT Y E MHRE GVLSAYKDNA S V I EGS TA GRFFPDP V T RQ YG AT QEP V HILMKVETHNHPTAI A PFPGA S TGSGGEIRDEGAT 320
Cdd:PRK05297 239 NT H E TNPD GVLSAYKDNA A V M EGS KV GRFFPDP D T GR YG YH QEP A HILMKVETHNHPTAI S PFPGA A TGSGGEIRDEGAT 318
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 321 GRG A KPKAGLTGF T VSNL Q IPGFEQPWE KP YGKPERI VTP LDIMIEGPLGGAAFNNEFGRP A L T GYFRTFEQ AIDT p H G E 400
Cdd:PRK05297 319 GRG S KPKAGLTGF S VSNL R IPGFEQPWE ED YGKPERI ASA LDIMIEGPLGGAAFNNEFGRP N L L GYFRTFEQ KVNS - H N E 397
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 401 EVRGYHKPIMLAGG M GNIRA E HVQKGEI SI GAKLIVLGGPAM L IGLGGGAASSMA T G S SS A DLDFASVQR D NPEMERRCQ 480
Cdd:PRK05297 398 EVRGYHKPIMLAGG I GNIRA D HVQKGEI PV GAKLIVLGGPAM R IGLGGGAASSMA S G Q SS E DLDFASVQR G NPEMERRCQ 477
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 481 EVIDRCWQ Q G A DNPI KF IHDVGAGG I SNA L PEL I NDGGRGGRF E LR AV PNDEPGMSPLEIWCNESQERYVL SVDAA D F E R 560
Cdd:PRK05297 478 EVIDRCWQ L G D DNPI LS IHDVGAGG L SNA F PEL V NDGGRGGRF D LR KI PNDEPGMSPLEIWCNESQERYVL AIAPE D L E L 557
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 561 F K AICERERCPFAVVGEA IA E P HLT VN DSHF G NK A VD M PL E VLLGKPP R MHR S V SREAELIDDFAAAEL D VED AV N RVL N 640
Cdd:PRK05297 558 F E AICERERCPFAVVGEA TE E R HLT LE DSHF D NK P VD L PL D VLLGKPP K MHR D V KTVKAKGPALDYSGI D LAE AV E RVL R 637
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 641 H P A VASK N FLITIGDR TI TGLVARDQMVGPWQVPVADCAVTA T S F D V Y T GEAMAMGERTP L ALL N A P AS G RMAVGE TI TN 720
Cdd:PRK05297 638 L P T VASK S FLITIGDR SV TGLVARDQMVGPWQVPVADCAVTA A S Y D G Y A GEAMAMGERTP V ALL D A A AS A RMAVGE AL TN 717
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 721 L AA SK I EK L SD IKLSANWMAAAGHPGEDARLYD T VKAVGMELCPALGITIPVGKDS M SMKT R WQ DE G V DK S VTSPLSLI V 800
Cdd:PRK05297 718 I AA AP I GD L KR IKLSANWMAAAGHPGEDARLYD A VKAVGMELCPALGITIPVGKDS L SMKT K WQ EG G E DK E VTSPLSLI I 797
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 801 TG FAPV T D I R Q TLTPQLR L DK g E T D L I LIDLGRG Q NRLGGS I LAQVY SK LG QQV PDVDDAEDLK A FF AV IQ G L N A D G H LL 880
Cdd:PRK05297 798 SA FAPV E D V R K TLTPQLR T DK - D T A L L LIDLGRG K NRLGGS A LAQVY NQ LG DKA PDVDDAEDLK G FF NA IQ A L V A E G L LL 876
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 881 AYHDRSDGGLL A T VL EMAFAGHCGLD LY LDAL A D N rdg LA A V LFNEELGAVIQVR QDATPE V L A QFSAA GL G DCV A VIG Q 960
Cdd:PRK05297 877 AYHDRSDGGLL T T LA EMAFAGHCGLD ID LDAL G D D --- AL A A LFNEELGAVIQVR AADRDA V E A ILAEH GL S DCV H VIG K 953
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 961 P VN G ADVA I SF NG GA VF GGE R RM L Q R Q W A ETSY RI QRLRDN A ECADQEFD TL L EEDN PGL S VKL A FD V N Q DIAAP Y I KK G 1040
Cdd:PRK05297 954 P NA G DRIV I TR NG KT VF SES R TE L R R W W S ETSY QM QRLRDN P ECADQEFD AI L DQAD PGL N VKL T FD P N E DIAAP F I AT G 1033
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1041 ARP Q VAILREQGVN GQ VEMAAAFDRAGF A AIDVHMSD I LAGRV S LEDFKGLVACGGFSYGDVLGAGEGWAKSILFN T R A R 1120
Cdd:PRK05297 1034 ARP K VAILREQGVN SH VEMAAAFDRAGF D AIDVHMSD L LAGRV T LEDFKGLVACGGFSYGDVLGAGEGWAKSILFN P R L R 1113
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1121 D G F Q AFF E R K D S F S LGVCNGCQMMSNL H E L IPG T E F WP H FVRNRSEQFEAR VAM V Q VQES S SIFL R GMAGSR M PIA I AHG 1200
Cdd:PRK05297 1114 D Q F E AFF A R P D T F A LGVCNGCQMMSNL K E I IPG A E H WP R FVRNRSEQFEAR FSL V E VQES P SIFL Q GMAGSR L PIA V AHG 1193
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1201 EG H AEF e SEEA L LEADLS G C VA M R F VDNHG K VTETYPANPNGSP R GITGLT SR DGRVTIMMPHPERVFR A VQNSW R P D EW 1280
Cdd:PRK05297 1194 EG R AEF - PDAH L AALEAK G L VA L R Y VDNHG Q VTETYPANPNGSP N GITGLT TA DGRVTIMMPHPERVFR T VQNSW H P E EW 1272
1290
....*....|....*...
gi 512733235 1281 Q ED AG WMRMFRNAR V WV D 1298
Cdd:PRK05297 1273 G ED SP WMRMFRNAR K WV G 1290
Name
Accession
Description
Interval
E-value
PRK05297
PRK05297 phosphoribosylformylglycinamidine synthase; Provisional
1-1298
0e+00
phosphoribosylformylglycinamidine synthase; Provisional
Pssm-ID: 235394 [Multi-domain]
Cd Length: 1290
Bit Score: 2715.76
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1 MLILRG A PALSAFR HG KLL EQ L TQK V SA V SGL YAE FT HFA EVTGV LS G EE EQV L A RLL K YGP SV pv Q EP S GRLFLV V PR V 80
Cdd:PRK05297 1 MLILRG S PALSAFR LQ KLL AR L QAA V LP V TSI YAE YV HFA DLSAP LS A EE QAK L E RLL T YGP AE -- H EP A GRLFLV T PR P 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 81 GTISPWSSKATDIA R NCGLA K I E R L ERGIAYYV AG A I S DADAE A I AA V LHDRMT QL V LPG L EE A AG LFSH AQ PKPLT V VD 160
Cdd:PRK05297 79 GTISPWSSKATDIA H NCGLA G I R R I ERGIAYYV EA A L S AEQRA A L AA L LHDRMT ES V FAD L DD A EA LFSH HE PKPLT S VD 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 161 I LGGGRAALE K ANVELGLALAEDEIDYLV KS F ND LGRNP H DVELMMFAQANSEHCRHKIFNA S W D IDG QA Q E KSLF G MIK 240
Cdd:PRK05297 159 V LGGGRAALE A ANVELGLALAEDEIDYLV EA F TK LGRNP T DVELMMFAQANSEHCRHKIFNA D W T IDG EE Q P KSLF K MIK 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 241 NT Y E MHRE GVLSAYKDNA S V I EGS TA GRFFPDP V T RQ YG AT QEP V HILMKVETHNHPTAI A PFPGA S TGSGGEIRDEGAT 320
Cdd:PRK05297 239 NT H E TNPD GVLSAYKDNA A V M EGS KV GRFFPDP D T GR YG YH QEP A HILMKVETHNHPTAI S PFPGA A TGSGGEIRDEGAT 318
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 321 GRG A KPKAGLTGF T VSNL Q IPGFEQPWE KP YGKPERI VTP LDIMIEGPLGGAAFNNEFGRP A L T GYFRTFEQ AIDT p H G E 400
Cdd:PRK05297 319 GRG S KPKAGLTGF S VSNL R IPGFEQPWE ED YGKPERI ASA LDIMIEGPLGGAAFNNEFGRP N L L GYFRTFEQ KVNS - H N E 397
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 401 EVRGYHKPIMLAGG M GNIRA E HVQKGEI SI GAKLIVLGGPAM L IGLGGGAASSMA T G S SS A DLDFASVQR D NPEMERRCQ 480
Cdd:PRK05297 398 EVRGYHKPIMLAGG I GNIRA D HVQKGEI PV GAKLIVLGGPAM R IGLGGGAASSMA S G Q SS E DLDFASVQR G NPEMERRCQ 477
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 481 EVIDRCWQ Q G A DNPI KF IHDVGAGG I SNA L PEL I NDGGRGGRF E LR AV PNDEPGMSPLEIWCNESQERYVL SVDAA D F E R 560
Cdd:PRK05297 478 EVIDRCWQ L G D DNPI LS IHDVGAGG L SNA F PEL V NDGGRGGRF D LR KI PNDEPGMSPLEIWCNESQERYVL AIAPE D L E L 557
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 561 F K AICERERCPFAVVGEA IA E P HLT VN DSHF G NK A VD M PL E VLLGKPP R MHR S V SREAELIDDFAAAEL D VED AV N RVL N 640
Cdd:PRK05297 558 F E AICERERCPFAVVGEA TE E R HLT LE DSHF D NK P VD L PL D VLLGKPP K MHR D V KTVKAKGPALDYSGI D LAE AV E RVL R 637
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 641 H P A VASK N FLITIGDR TI TGLVARDQMVGPWQVPVADCAVTA T S F D V Y T GEAMAMGERTP L ALL N A P AS G RMAVGE TI TN 720
Cdd:PRK05297 638 L P T VASK S FLITIGDR SV TGLVARDQMVGPWQVPVADCAVTA A S Y D G Y A GEAMAMGERTP V ALL D A A AS A RMAVGE AL TN 717
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 721 L AA SK I EK L SD IKLSANWMAAAGHPGEDARLYD T VKAVGMELCPALGITIPVGKDS M SMKT R WQ DE G V DK S VTSPLSLI V 800
Cdd:PRK05297 718 I AA AP I GD L KR IKLSANWMAAAGHPGEDARLYD A VKAVGMELCPALGITIPVGKDS L SMKT K WQ EG G E DK E VTSPLSLI I 797
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 801 TG FAPV T D I R Q TLTPQLR L DK g E T D L I LIDLGRG Q NRLGGS I LAQVY SK LG QQV PDVDDAEDLK A FF AV IQ G L N A D G H LL 880
Cdd:PRK05297 798 SA FAPV E D V R K TLTPQLR T DK - D T A L L LIDLGRG K NRLGGS A LAQVY NQ LG DKA PDVDDAEDLK G FF NA IQ A L V A E G L LL 876
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 881 AYHDRSDGGLL A T VL EMAFAGHCGLD LY LDAL A D N rdg LA A V LFNEELGAVIQVR QDATPE V L A QFSAA GL G DCV A VIG Q 960
Cdd:PRK05297 877 AYHDRSDGGLL T T LA EMAFAGHCGLD ID LDAL G D D --- AL A A LFNEELGAVIQVR AADRDA V E A ILAEH GL S DCV H VIG K 953
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 961 P VN G ADVA I SF NG GA VF GGE R RM L Q R Q W A ETSY RI QRLRDN A ECADQEFD TL L EEDN PGL S VKL A FD V N Q DIAAP Y I KK G 1040
Cdd:PRK05297 954 P NA G DRIV I TR NG KT VF SES R TE L R R W W S ETSY QM QRLRDN P ECADQEFD AI L DQAD PGL N VKL T FD P N E DIAAP F I AT G 1033
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1041 ARP Q VAILREQGVN GQ VEMAAAFDRAGF A AIDVHMSD I LAGRV S LEDFKGLVACGGFSYGDVLGAGEGWAKSILFN T R A R 1120
Cdd:PRK05297 1034 ARP K VAILREQGVN SH VEMAAAFDRAGF D AIDVHMSD L LAGRV T LEDFKGLVACGGFSYGDVLGAGEGWAKSILFN P R L R 1113
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1121 D G F Q AFF E R K D S F S LGVCNGCQMMSNL H E L IPG T E F WP H FVRNRSEQFEAR VAM V Q VQES S SIFL R GMAGSR M PIA I AHG 1200
Cdd:PRK05297 1114 D Q F E AFF A R P D T F A LGVCNGCQMMSNL K E I IPG A E H WP R FVRNRSEQFEAR FSL V E VQES P SIFL Q GMAGSR L PIA V AHG 1193
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1201 EG H AEF e SEEA L LEADLS G C VA M R F VDNHG K VTETYPANPNGSP R GITGLT SR DGRVTIMMPHPERVFR A VQNSW R P D EW 1280
Cdd:PRK05297 1194 EG R AEF - PDAH L AALEAK G L VA L R Y VDNHG Q VTETYPANPNGSP N GITGLT TA DGRVTIMMPHPERVFR T VQNSW H P E EW 1272
1290
....*....|....*...
gi 512733235 1281 Q ED AG WMRMFRNAR V WV D 1298
Cdd:PRK05297 1273 G ED SP WMRMFRNAR K WV G 1290
FGAM_synt
TIGR01735 phosphoribosylformylglycinamidine synthase, single chain form; This model represents a ...
3-1297
0e+00
phosphoribosylformylglycinamidine synthase, single chain form; This model represents a single-molecule form of phosphoribosylformylglycinamidine synthase, also called FGAM synthase, an enzyme of purine de novo biosynthesis. This form is found mostly in eukaryotes and Proteobacteria. In Bacillus subtilis PurL (FGAM synthase II) and PurQ (FGAM synthase I), homologous to different parts of this model, perform the equivalent function; the unrelated small protein PurS is also required and may be a third subunit. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 188163 [Multi-domain]
Cd Length: 1310
Bit Score: 2276.62
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 3 I LRG AP ALS A FR HG KLL EQ L TQ KV SAVS G L YAEF TH F AEVTGV L SGE EE QV L AR LL KY G PSVPV - Q E P S GR - L FL V V PR V 80
Cdd:TIGR01735 1 F LRG PS ALS G FR LE KLL QK L QT KV PELT G V YAEF CY F VGWESA L TAD EE EK L QL LL LA G SVLEP p Q S P L GR g L LE V G PR L 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 81 GTISPWSSKAT D IARNCGLAK IE R L ERG IA YY VA GA -- I S DADAEAI AA V LHDRMT QL VLP GLE EA AG LFS HAQ P KP LT V 158
Cdd:TIGR01735 81 GTISPWSSKAT S IARNCGLAK VD R I ERG RR YY LS GA hp L S EEQEAQA AA L LHDRMT ES VLP HEI EA FE LFS VPE P LN LT T 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 159 V D I LGGGR A ALEKAN V ELGLAL A EDEIDYL V K S F ND L G RNP H DVELMMFAQANSEHCRHKIFNA S W D IDG QA Q E KSLF G M 238
Cdd:TIGR01735 161 I D V LGGGR L ALEKAN Q ELGLAL D EDEIDYL T K R F QE L Q RNP S DVELMMFAQANSEHCRHKIFNA D W I IDG KK Q D KSLF Q M 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 239 IK N T Y E MHR E GVL SAYKDN A SVIEG STA GR FF PDP V TR Q - Y GAT QE - P VHILMKVETHNHPTAIAPFPGASTG S GGEIRD 316
Cdd:TIGR01735 241 IK S T H E ANP E NTV SAYKDN S SVIEG HKV GR LR PDP P TR P e Y RQH QE d L VHILMKVETHNHPTAIAPFPGASTG A GGEIRD 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 317 EGATGRGAKPKAGLTGF T VSNL Q IPG F EQPWE K P YG KPERI VT PLDIMIE G PLG G AAFNNEFGRP A L T GYFRTFE QAIDT 396
Cdd:TIGR01735 321 EGATGRGAKPKAGLTGF C VSNL N IPG L EQPWE D P FQ KPERI AS PLDIMIE A PLG A AAFNNEFGRP N L L GYFRTFE LKASL 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 397 P h G EE VRGYHKPIMLAGG M G N I R AEH V QKGEI SI GA K LIVLGGPAMLIGLGGGAASSM AT G SSS ADLDFASVQR D NPEME 476
Cdd:TIGR01735 401 P - G GQ VRGYHKPIMLAGG I G S I D AEH I QKGEI EP GA L LIVLGGPAMLIGLGGGAASSM VS G TNT ADLDFASVQR G NPEME 479
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 477 RRCQEVIDRCWQ Q G AD NPI KF IHDVGAGG I SNALPELI N DGGRG GRFE LRAVP N D E PG M SPLEIWCNESQERYVL S V D A A 556
Cdd:TIGR01735 480 RRCQEVIDRCWQ L G EK NPI IS IHDVGAGG L SNALPELI H DGGRG AVID LRAVP L D D PG L SPLEIWCNESQERYVL L V R A E 559
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 557 DF E R F K AICERERCPFAVVG E A IAEPH LT VN D ------------- SHF G N KA VD M PLEVLLGK P P R M H R S V S R E A ELIDD 623
Cdd:TIGR01735 560 NL E I F T AICERERCPFAVVG T A TGDGR LT LV D dtpvrrngqgdap SHF P N NP VD L PLEVLLGK M P K M T R F V Q R K A PMLQP 639
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 624 FAAAE - LD VED A VN RVL NH PAVASK N FLITIGDR TIT GLVARDQMVGPWQ V P V AD C AVTA T SFD V YTGEAMA M GER T P L A 702
Cdd:TIGR01735 640 LDIPP g LD LHE A LE RVL RL PAVASK R FLITIGDR SVG GLVARDQMVGPWQ T P L AD V AVTA A SFD T YTGEAMA I GER P P K A 719
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 703 LL NAP AS G R M AVGE T ITNLAA SKIEK LSD I KLSANWMAAAGHPGEDA R LYD T VKAV g M ELCPALGI T IPVGKDS M SMKTR 782
Cdd:TIGR01735 720 LL DPK AS A R L AVGE A ITNLAA ALVGD LSD V KLSANWMAAAGHPGEDA A LYD A VKAV - S ELCPALGI A IPVGKDS L SMKTR 798
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 783 WQD E G VD KSVT S P L SL IVTG FAPV T D I R Q T L TP Q L RL DKG ETD L I L I DLG R G Q NRLGGS I LAQV YSK LG QQV PD V DD A E D 862
Cdd:TIGR01735 799 WQD N G ET KSVT A P G SL VISA FAPV P D V R K T V TP D L KH DKG DSH L L L V DLG P G K NRLGGS A LAQV FGQ LG GDC PD L DD P E R 878
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 863 LKAFFAV I QGL N A D G H LLAYHDRSDGGL LA T V LEMAFAGHCGLD LY LDAL A D N rdg L A AVLFNEELGAVIQV RQDATPE V 942
Cdd:TIGR01735 879 LKAFFAV M QGL V A E G L LLAYHDRSDGGL VT T L LEMAFAGHCGLD VD LDAL G D S --- L F AVLFNEELGAVIQV AKPDLAA V 955
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 943 L AQFS AAGL GDCVAV IG Q P VNGADVA IS F NG GAVFGGE R RM L QRQ W A ETS YRI QRLRDN A ECA DQ EF DT L LEE D N PGL SV 1022
Cdd:TIGR01735 956 L ELLR AAGL TALILG IG T P TGHPMIR IS V NG ATLLSEK R SE L RDI W E ETS FQL QRLRDN P ECA EE EF EG L RDR D G PGL KL 1035
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1023 K L A FDVN Q DIAAP Y I K KG AR P Q VAILREQGVNG QV EMAAAFDRAGF A A I DVHMSD I LAGRV S L ED F K GL V ACGGFSYGDV 1102
Cdd:TIGR01735 1036 P L T FDVN E DIAAP F I N KG VK P K VAILREQGVNG DR EMAAAFDRAGF E A W DVHMSD L LAGRV H L DE F R GL A ACGGFSYGDV 1115
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1103 LGAG E GWAKSILFN T R A RD G FQAFF E R K D S FSLGVCNGCQM M SNL H E L IPGTE F WPHFVRN R SE Q FEARVA M V Q V Q ES S S 1182
Cdd:TIGR01735 1116 LGAG K GWAKSILFN P R L RD Q FQAFF K R P D T FSLGVCNGCQM L SNL L E W IPGTE N WPHFVRN N SE R FEARVA S V R V G ES P S 1195
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1183 I F LRGMAGSR M P I A I AHGEG H A E F E S E E ALLE AD L SG CV A M R FV D NH G KV TE T YP A NPNGSP R GI T G L TS R DGRVTIMMP 1262
Cdd:TIGR01735 1196 I M LRGMAGSR L P V A V AHGEG Y A A F S S P E LQAQ AD A SG LA A L R YI D DD G NP TE A YP L NPNGSP G GI A G I TS C DGRVTIMMP 1275
1290 1300 1310
....*....|....*....|....*....|....*
gi 512733235 1263 HPERVFRA V QNSWRP DE W Q ED AG W M R M FRNAR V W V 1297
Cdd:TIGR01735 1276 HPERVFRA W QNSWRP ED W D ED TP W L R L FRNAR N W L 1310
PurL1
COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and ...
162-1001
0e+00
Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain is part of the Pathway/BioSystem: Purine biosynthesis
Pssm-ID: 439816 [Multi-domain]
Cd Length: 747
Bit Score: 1028.07
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 162 L G GGR A ALE K AN V ELGLAL AE DE I DY L V K sfn D LGRNP H DVEL M MF A Q AN SEHC RH K IF NA SW didgqaqekslfgmik N 241
Cdd:COG0046 6 L E GGR E ALE E AN R ELGLAL SD DE Y DY I V E --- I LGRNP T DVEL G MF S Q MW SEHC SY K SS NA LL ---------------- K 66
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 242 TYEMHREG VLS AYK DNA S V IEGS tagrffpdpvtrqygatq EPVHILM KVE T HNHP T AI A P FP GA S TG S GG E IRD EG at G 321
Cdd:COG0046 67 SLPTEGPR VLS GPG DNA G V VDIG ------------------ DGLAVVF KVE S HNHP S AI E P YQ GA A TG V GG I IRD IF -- G 126
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 322 R GA K P K AGL TGFTVS NL qipgf E QP W ekpygkperi VT P LD I M I EGPL G G A AFN N E FG R P ALT G YF R TF E Q aidtphgee 401
Cdd:COG0046 127 M GA R P I AGL DSLRFG NL ----- D QP P ---------- AS P RY I L I GVVA G I A DYG N C FG V P TVG G EV R FD E S --------- 182
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 402 vrg Y - HK P IML AGG M G N IRA E H VQ K G - EISI G A K LIVL GGP AMLI G L GG GAAS S MAT G SS S A d LD FAS VQ RDN P E ME R R C 479
Cdd:COG0046 183 --- Y e GN P LVN AGG V G I IRA D H IF K A k APGV G N K VVYV GGP TGRD G I GG ATFA S EEL G ED S E - LD RPA VQ VGD P F ME K R L 258
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 480 Q E V I DRC wqq G ADNP I KF I H D V GAGG I S N A LP E LIND GG R G GRFE L RA VP ND EPGMSP L EIW CN ESQER YV L S V DAADF E 559
Cdd:COG0046 259 I E A I LEL --- G DTGL I VG I Q D M GAGG L S S A SS E MAAK GG L G AEID L DK VP LR EPGMSP Y EIW LS ESQER ML L V V KPEKL E 335
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 560 R F K AI C ER E R C P F AV V GE AIAEPH L T V N ds HF G NKAV D M PL EV L L G KP P RM HR SVS R E A E L IDDFAAAEL D V E D A VN R V L 639
Cdd:COG0046 336 E F E AI F ER W R L P A AV I GE VTDDGR L V V T -- DH G ETVA D L PL DF L A G GA P KY HR PAK R P A Y L EPLDLPEPI D L E E A LL R L L 413
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 640 NH P A VASK NF L ITIG DR TIT G LVA RD Q mvgpwqv P VAD C AV TATS f DV Y T G E AM AM GE RTPL ALL NAP A SG RMAV G E TIT 719
Cdd:COG0046 414 SS P N VASK EW L YRQY DR EVG G NTV RD P ------- G VAD A AV VRVD - GT Y K G L AM ST GE NPRY ALL DPY A GA RMAV A E AAR 485
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 720 NLAA SKI E K L s D I KLSA NW MAAA g H P G E D A R L YDT VK AVG m EL C P ALGI TI P V G KD S MSMK T R wqdegv D KS V TS P LSLI 799
Cdd:COG0046 486 NLAA VGA E P L - A I TDCL NW GNPE - K P E E M A Q L VEA VK GLA - DA C R ALGI PV P S G NV S LYNE T K ------ D GK V AI P PTPV 556
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 800 VTGFAP V T D I R Q T L TP Q L RLD kg ETD L I LI dl G RGQ N R LGGS IL AQV YSK LG QQV PDV d D A E DL KA F F AVI Q G L NAD G HL 879
Cdd:COG0046 557 IGAVGL V D D V R K T V TP D L KKE -- GDL L Y LI -- G ETK N E LGGS EY AQV LGQ LG GEP PDV - D L E AE KA L F EAV Q E L IRE G LI 631
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 880 LA Y HD R SDGGL LATVL EMAFAG HC G L D LY LDAL A D N R D gl A A V LF N E EL G - AV I QV RQDATPE V L A QFSA AGL gd CVA VI 958
Cdd:COG0046 632 LA A HD V SDGGL AVALA EMAFAG GL G A D ID LDAL G D L R P -- D A A LF S E SQ G r AV V QV APEDAEA V E A LLAE AGL -- PAH VI 707
810 820 830 840
....*....|....*....|....*....|....*....|...
gi 512733235 959 G QPVNGADVA I SFN G GAVFGGERRM L QRQ W A ET syr IQ RLRDN 1001
Cdd:COG0046 708 G TVTGDDRLV I RRG G ETLLSLSLAE L RDA W E ET --- LP RLRDN 747
GATase_5
pfam13507 CobB/CobQ-like glutamine amidotransferase domain; This family captures members that are not ...
1042-1297
4.17e-150
CobB/CobQ-like glutamine amidotransferase domain; This family captures members that are not found in pfam00310, pfam07685 and pfam13230.
Pssm-ID: 463904 [Multi-domain]
Cd Length: 260
Bit Score: 452.72
E-value: 4.17e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1042 R P Q VAILRE Q G V NG QV EMAAAF D RAGF A A I DVHMSD I L A GRVSL E DF K GL V A C GGFSYGDVLG A G E GWA K SILFN TRA RD 1121
Cdd:pfam13507 1 K P R VAILRE P G T NG EY EMAAAF E RAGF D A V DVHMSD L L S GRVSL D DF Q GL A A P GGFSYGDVLG S G K GWA A SILFN PKL RD 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1122 G F Q AFF E R K D S FSLG V CNGCQ MM S N L H e LIPG T E F ----- WP HFV RN R S EQ FE A R VAM V QV - QE S S S I FLRGM A GS RM P i 1195
Cdd:pfam13507 81 A F E AFF N R P D T FSLG I CNGCQ LL S K L G - LIPG G E G dlaer WP TLT RN D S GR FE S R WVN V KI s EK S P S V FLRGM D GS GL P - 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1196 a I AHGEG HAE F E SEE A L LEADLS G C VA M R F VDN H G KV TE T YP A NPNGSP R GI T G LT S R DGRV TIM MPHPERVFR AV Q NS - 1274
Cdd:pfam13507 159 - V AHGEG RFV F R SEE V L ARLEAN G Q VA L R Y VDN A G NP TE E YP F NPNGSP L GI A G IC S P DGRV LGL MPHPERVFR PW Q WP h 237
250 260
....*....|....*....|...
gi 512733235 1275 W R P D EW Q E DAG W M R M FRNAR V WV 1297
Cdd:pfam13507 238 W P P G EW E E VSP W L R L FRNAR K WV 260
PurL_repeat1
cd02203 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. ...
203-598
1.28e-129
PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100034 [Multi-domain]
Cd Length: 313
Bit Score: 401.08
E-value: 1.28e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 203 EL M MFAQ AN SEHCRHK I F naswdidgqaqe KSL FG MI kntyemhregvlsaykdnasviegstagrffpdpvtrqygatq 282
Cdd:cd02203 1 EL G MFAQ MW SEHCRHK S F ------------ KSL LK MI ------------------------------------------- 25
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 283 ep VHILM KVETHNHP T AI A PF P GA S TG S GG E IRD EGAT G rg A K P K A G L T G FTVSN L Q IPG F E qpwekpygk P ERIVT P LD 362
Cdd:cd02203 26 -- WAVVF KVETHNHP S AI E PF G GA A TG V GG I IRD ILSM G -- A R P I A L L D G LRFGD L D IPG Y E --------- P KGKLS P RR 92
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 363 I MIEGPL G GAAFN N EF G R P ALT G YF R TFE qaidtphgeev RG Y HK P IMLA G GM G NIRAE H VQ K G - EISI G AKLIVL GG PA 441
Cdd:cd02203 93 I LDGVVA G ISDYG N CI G I P TVG G EV R FDP ----------- SY Y GN P LVNV G CV G IVPKD H IV K S k APGP G DLVVLV GG RT 161
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 442 MLI G L GG GAA SS MATGSS S AD LD FAS VQ RDN P E ME RRC QE V I DRCWQ qga DNP I KF I H D V GAGG I S N A LP E LIND GG R G G 521
Cdd:cd02203 162 GRD G I GG ATF SS KELSEN S SE LD RPA VQ VGD P F ME KKL QE A I LEARE --- TGL I VG I Q D L GAGG L S S A VS E MAAK GG L G A 238
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 512733235 522 RFE L RA VP ND EPGMSP L EIW CN ESQER YV L S V DAA D F E R F K AIC ER E RCPF AV V GE AIAEPH L TVNDS hf G NKAV D M 598
Cdd:cd02203 239 EID L DK VP LR EPGMSP W EIW IS ESQER ML L V V PPE D L E E F L AIC KK E DLEA AV I GE VTDDGR L RLYYK -- G EVVA D L 313
Name
Accession
Description
Interval
E-value
PRK05297
PRK05297 phosphoribosylformylglycinamidine synthase; Provisional
1-1298
0e+00
phosphoribosylformylglycinamidine synthase; Provisional
Pssm-ID: 235394 [Multi-domain]
Cd Length: 1290
Bit Score: 2715.76
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1 MLILRG A PALSAFR HG KLL EQ L TQK V SA V SGL YAE FT HFA EVTGV LS G EE EQV L A RLL K YGP SV pv Q EP S GRLFLV V PR V 80
Cdd:PRK05297 1 MLILRG S PALSAFR LQ KLL AR L QAA V LP V TSI YAE YV HFA DLSAP LS A EE QAK L E RLL T YGP AE -- H EP A GRLFLV T PR P 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 81 GTISPWSSKATDIA R NCGLA K I E R L ERGIAYYV AG A I S DADAE A I AA V LHDRMT QL V LPG L EE A AG LFSH AQ PKPLT V VD 160
Cdd:PRK05297 79 GTISPWSSKATDIA H NCGLA G I R R I ERGIAYYV EA A L S AEQRA A L AA L LHDRMT ES V FAD L DD A EA LFSH HE PKPLT S VD 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 161 I LGGGRAALE K ANVELGLALAEDEIDYLV KS F ND LGRNP H DVELMMFAQANSEHCRHKIFNA S W D IDG QA Q E KSLF G MIK 240
Cdd:PRK05297 159 V LGGGRAALE A ANVELGLALAEDEIDYLV EA F TK LGRNP T DVELMMFAQANSEHCRHKIFNA D W T IDG EE Q P KSLF K MIK 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 241 NT Y E MHRE GVLSAYKDNA S V I EGS TA GRFFPDP V T RQ YG AT QEP V HILMKVETHNHPTAI A PFPGA S TGSGGEIRDEGAT 320
Cdd:PRK05297 239 NT H E TNPD GVLSAYKDNA A V M EGS KV GRFFPDP D T GR YG YH QEP A HILMKVETHNHPTAI S PFPGA A TGSGGEIRDEGAT 318
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 321 GRG A KPKAGLTGF T VSNL Q IPGFEQPWE KP YGKPERI VTP LDIMIEGPLGGAAFNNEFGRP A L T GYFRTFEQ AIDT p H G E 400
Cdd:PRK05297 319 GRG S KPKAGLTGF S VSNL R IPGFEQPWE ED YGKPERI ASA LDIMIEGPLGGAAFNNEFGRP N L L GYFRTFEQ KVNS - H N E 397
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 401 EVRGYHKPIMLAGG M GNIRA E HVQKGEI SI GAKLIVLGGPAM L IGLGGGAASSMA T G S SS A DLDFASVQR D NPEMERRCQ 480
Cdd:PRK05297 398 EVRGYHKPIMLAGG I GNIRA D HVQKGEI PV GAKLIVLGGPAM R IGLGGGAASSMA S G Q SS E DLDFASVQR G NPEMERRCQ 477
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 481 EVIDRCWQ Q G A DNPI KF IHDVGAGG I SNA L PEL I NDGGRGGRF E LR AV PNDEPGMSPLEIWCNESQERYVL SVDAA D F E R 560
Cdd:PRK05297 478 EVIDRCWQ L G D DNPI LS IHDVGAGG L SNA F PEL V NDGGRGGRF D LR KI PNDEPGMSPLEIWCNESQERYVL AIAPE D L E L 557
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 561 F K AICERERCPFAVVGEA IA E P HLT VN DSHF G NK A VD M PL E VLLGKPP R MHR S V SREAELIDDFAAAEL D VED AV N RVL N 640
Cdd:PRK05297 558 F E AICERERCPFAVVGEA TE E R HLT LE DSHF D NK P VD L PL D VLLGKPP K MHR D V KTVKAKGPALDYSGI D LAE AV E RVL R 637
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 641 H P A VASK N FLITIGDR TI TGLVARDQMVGPWQVPVADCAVTA T S F D V Y T GEAMAMGERTP L ALL N A P AS G RMAVGE TI TN 720
Cdd:PRK05297 638 L P T VASK S FLITIGDR SV TGLVARDQMVGPWQVPVADCAVTA A S Y D G Y A GEAMAMGERTP V ALL D A A AS A RMAVGE AL TN 717
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 721 L AA SK I EK L SD IKLSANWMAAAGHPGEDARLYD T VKAVGMELCPALGITIPVGKDS M SMKT R WQ DE G V DK S VTSPLSLI V 800
Cdd:PRK05297 718 I AA AP I GD L KR IKLSANWMAAAGHPGEDARLYD A VKAVGMELCPALGITIPVGKDS L SMKT K WQ EG G E DK E VTSPLSLI I 797
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 801 TG FAPV T D I R Q TLTPQLR L DK g E T D L I LIDLGRG Q NRLGGS I LAQVY SK LG QQV PDVDDAEDLK A FF AV IQ G L N A D G H LL 880
Cdd:PRK05297 798 SA FAPV E D V R K TLTPQLR T DK - D T A L L LIDLGRG K NRLGGS A LAQVY NQ LG DKA PDVDDAEDLK G FF NA IQ A L V A E G L LL 876
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 881 AYHDRSDGGLL A T VL EMAFAGHCGLD LY LDAL A D N rdg LA A V LFNEELGAVIQVR QDATPE V L A QFSAA GL G DCV A VIG Q 960
Cdd:PRK05297 877 AYHDRSDGGLL T T LA EMAFAGHCGLD ID LDAL G D D --- AL A A LFNEELGAVIQVR AADRDA V E A ILAEH GL S DCV H VIG K 953
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 961 P VN G ADVA I SF NG GA VF GGE R RM L Q R Q W A ETSY RI QRLRDN A ECADQEFD TL L EEDN PGL S VKL A FD V N Q DIAAP Y I KK G 1040
Cdd:PRK05297 954 P NA G DRIV I TR NG KT VF SES R TE L R R W W S ETSY QM QRLRDN P ECADQEFD AI L DQAD PGL N VKL T FD P N E DIAAP F I AT G 1033
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1041 ARP Q VAILREQGVN GQ VEMAAAFDRAGF A AIDVHMSD I LAGRV S LEDFKGLVACGGFSYGDVLGAGEGWAKSILFN T R A R 1120
Cdd:PRK05297 1034 ARP K VAILREQGVN SH VEMAAAFDRAGF D AIDVHMSD L LAGRV T LEDFKGLVACGGFSYGDVLGAGEGWAKSILFN P R L R 1113
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1121 D G F Q AFF E R K D S F S LGVCNGCQMMSNL H E L IPG T E F WP H FVRNRSEQFEAR VAM V Q VQES S SIFL R GMAGSR M PIA I AHG 1200
Cdd:PRK05297 1114 D Q F E AFF A R P D T F A LGVCNGCQMMSNL K E I IPG A E H WP R FVRNRSEQFEAR FSL V E VQES P SIFL Q GMAGSR L PIA V AHG 1193
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1201 EG H AEF e SEEA L LEADLS G C VA M R F VDNHG K VTETYPANPNGSP R GITGLT SR DGRVTIMMPHPERVFR A VQNSW R P D EW 1280
Cdd:PRK05297 1194 EG R AEF - PDAH L AALEAK G L VA L R Y VDNHG Q VTETYPANPNGSP N GITGLT TA DGRVTIMMPHPERVFR T VQNSW H P E EW 1272
1290
....*....|....*...
gi 512733235 1281 Q ED AG WMRMFRNAR V WV D 1298
Cdd:PRK05297 1273 G ED SP WMRMFRNAR K WV G 1290
FGAM_synt
TIGR01735 phosphoribosylformylglycinamidine synthase, single chain form; This model represents a ...
3-1297
0e+00
phosphoribosylformylglycinamidine synthase, single chain form; This model represents a single-molecule form of phosphoribosylformylglycinamidine synthase, also called FGAM synthase, an enzyme of purine de novo biosynthesis. This form is found mostly in eukaryotes and Proteobacteria. In Bacillus subtilis PurL (FGAM synthase II) and PurQ (FGAM synthase I), homologous to different parts of this model, perform the equivalent function; the unrelated small protein PurS is also required and may be a third subunit. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 188163 [Multi-domain]
Cd Length: 1310
Bit Score: 2276.62
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 3 I LRG AP ALS A FR HG KLL EQ L TQ KV SAVS G L YAEF TH F AEVTGV L SGE EE QV L AR LL KY G PSVPV - Q E P S GR - L FL V V PR V 80
Cdd:TIGR01735 1 F LRG PS ALS G FR LE KLL QK L QT KV PELT G V YAEF CY F VGWESA L TAD EE EK L QL LL LA G SVLEP p Q S P L GR g L LE V G PR L 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 81 GTISPWSSKAT D IARNCGLAK IE R L ERG IA YY VA GA -- I S DADAEAI AA V LHDRMT QL VLP GLE EA AG LFS HAQ P KP LT V 158
Cdd:TIGR01735 81 GTISPWSSKAT S IARNCGLAK VD R I ERG RR YY LS GA hp L S EEQEAQA AA L LHDRMT ES VLP HEI EA FE LFS VPE P LN LT T 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 159 V D I LGGGR A ALEKAN V ELGLAL A EDEIDYL V K S F ND L G RNP H DVELMMFAQANSEHCRHKIFNA S W D IDG QA Q E KSLF G M 238
Cdd:TIGR01735 161 I D V LGGGR L ALEKAN Q ELGLAL D EDEIDYL T K R F QE L Q RNP S DVELMMFAQANSEHCRHKIFNA D W I IDG KK Q D KSLF Q M 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 239 IK N T Y E MHR E GVL SAYKDN A SVIEG STA GR FF PDP V TR Q - Y GAT QE - P VHILMKVETHNHPTAIAPFPGASTG S GGEIRD 316
Cdd:TIGR01735 241 IK S T H E ANP E NTV SAYKDN S SVIEG HKV GR LR PDP P TR P e Y RQH QE d L VHILMKVETHNHPTAIAPFPGASTG A GGEIRD 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 317 EGATGRGAKPKAGLTGF T VSNL Q IPG F EQPWE K P YG KPERI VT PLDIMIE G PLG G AAFNNEFGRP A L T GYFRTFE QAIDT 396
Cdd:TIGR01735 321 EGATGRGAKPKAGLTGF C VSNL N IPG L EQPWE D P FQ KPERI AS PLDIMIE A PLG A AAFNNEFGRP N L L GYFRTFE LKASL 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 397 P h G EE VRGYHKPIMLAGG M G N I R AEH V QKGEI SI GA K LIVLGGPAMLIGLGGGAASSM AT G SSS ADLDFASVQR D NPEME 476
Cdd:TIGR01735 401 P - G GQ VRGYHKPIMLAGG I G S I D AEH I QKGEI EP GA L LIVLGGPAMLIGLGGGAASSM VS G TNT ADLDFASVQR G NPEME 479
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 477 RRCQEVIDRCWQ Q G AD NPI KF IHDVGAGG I SNALPELI N DGGRG GRFE LRAVP N D E PG M SPLEIWCNESQERYVL S V D A A 556
Cdd:TIGR01735 480 RRCQEVIDRCWQ L G EK NPI IS IHDVGAGG L SNALPELI H DGGRG AVID LRAVP L D D PG L SPLEIWCNESQERYVL L V R A E 559
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 557 DF E R F K AICERERCPFAVVG E A IAEPH LT VN D ------------- SHF G N KA VD M PLEVLLGK P P R M H R S V S R E A ELIDD 623
Cdd:TIGR01735 560 NL E I F T AICERERCPFAVVG T A TGDGR LT LV D dtpvrrngqgdap SHF P N NP VD L PLEVLLGK M P K M T R F V Q R K A PMLQP 639
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 624 FAAAE - LD VED A VN RVL NH PAVASK N FLITIGDR TIT GLVARDQMVGPWQ V P V AD C AVTA T SFD V YTGEAMA M GER T P L A 702
Cdd:TIGR01735 640 LDIPP g LD LHE A LE RVL RL PAVASK R FLITIGDR SVG GLVARDQMVGPWQ T P L AD V AVTA A SFD T YTGEAMA I GER P P K A 719
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 703 LL NAP AS G R M AVGE T ITNLAA SKIEK LSD I KLSANWMAAAGHPGEDA R LYD T VKAV g M ELCPALGI T IPVGKDS M SMKTR 782
Cdd:TIGR01735 720 LL DPK AS A R L AVGE A ITNLAA ALVGD LSD V KLSANWMAAAGHPGEDA A LYD A VKAV - S ELCPALGI A IPVGKDS L SMKTR 798
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 783 WQD E G VD KSVT S P L SL IVTG FAPV T D I R Q T L TP Q L RL DKG ETD L I L I DLG R G Q NRLGGS I LAQV YSK LG QQV PD V DD A E D 862
Cdd:TIGR01735 799 WQD N G ET KSVT A P G SL VISA FAPV P D V R K T V TP D L KH DKG DSH L L L V DLG P G K NRLGGS A LAQV FGQ LG GDC PD L DD P E R 878
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 863 LKAFFAV I QGL N A D G H LLAYHDRSDGGL LA T V LEMAFAGHCGLD LY LDAL A D N rdg L A AVLFNEELGAVIQV RQDATPE V 942
Cdd:TIGR01735 879 LKAFFAV M QGL V A E G L LLAYHDRSDGGL VT T L LEMAFAGHCGLD VD LDAL G D S --- L F AVLFNEELGAVIQV AKPDLAA V 955
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 943 L AQFS AAGL GDCVAV IG Q P VNGADVA IS F NG GAVFGGE R RM L QRQ W A ETS YRI QRLRDN A ECA DQ EF DT L LEE D N PGL SV 1022
Cdd:TIGR01735 956 L ELLR AAGL TALILG IG T P TGHPMIR IS V NG ATLLSEK R SE L RDI W E ETS FQL QRLRDN P ECA EE EF EG L RDR D G PGL KL 1035
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1023 K L A FDVN Q DIAAP Y I K KG AR P Q VAILREQGVNG QV EMAAAFDRAGF A A I DVHMSD I LAGRV S L ED F K GL V ACGGFSYGDV 1102
Cdd:TIGR01735 1036 P L T FDVN E DIAAP F I N KG VK P K VAILREQGVNG DR EMAAAFDRAGF E A W DVHMSD L LAGRV H L DE F R GL A ACGGFSYGDV 1115
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1103 LGAG E GWAKSILFN T R A RD G FQAFF E R K D S FSLGVCNGCQM M SNL H E L IPGTE F WPHFVRN R SE Q FEARVA M V Q V Q ES S S 1182
Cdd:TIGR01735 1116 LGAG K GWAKSILFN P R L RD Q FQAFF K R P D T FSLGVCNGCQM L SNL L E W IPGTE N WPHFVRN N SE R FEARVA S V R V G ES P S 1195
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1183 I F LRGMAGSR M P I A I AHGEG H A E F E S E E ALLE AD L SG CV A M R FV D NH G KV TE T YP A NPNGSP R GI T G L TS R DGRVTIMMP 1262
Cdd:TIGR01735 1196 I M LRGMAGSR L P V A V AHGEG Y A A F S S P E LQAQ AD A SG LA A L R YI D DD G NP TE A YP L NPNGSP G GI A G I TS C DGRVTIMMP 1275
1290 1300 1310
....*....|....*....|....*....|....*
gi 512733235 1263 HPERVFRA V QNSWRP DE W Q ED AG W M R M FRNAR V W V 1297
Cdd:TIGR01735 1276 HPERVFRA W QNSWRP ED W D ED TP W L R L FRNAR N W L 1310
PLN03206
PLN03206 phosphoribosylformylglycinamidine synthase; Provisional
18-1298
0e+00
phosphoribosylformylglycinamidine synthase; Provisional
Pssm-ID: 178745 [Multi-domain]
Cd Length: 1307
Bit Score: 1128.71
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 18 LL EQLTQ KVS - AVSGLYA E FTHFAEVTGV LS G E EEQV L AR LL K -- YG P ------ S VPVQEP S GR L FL VV ---- PR VGTIS 84
Cdd:PLN03206 3 LL RKVQT KVS n DIVSIET E QCFNVGLESP LS A E KLET L KW LL R et FE P enlgte S FLEAKK S EG L NA VV vevg PR LSFTT 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 85 P WS SK A TD I ARN CGL AKIE RLER GIA Y -- YVAGAISDADAE A I AA VL HDRMT QL V L P gl EEAAGLF S HAQ P K P LTV V DIL 162
Cdd:PLN03206 83 A WS TN A VS I CSA CGL TEVT RLER SRR Y ll FSSSPLDESQIN A F AA MV HDRMT EC V Y P -- QPLTSFE S GVV P E P VYT V PVM 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 163 GG GRAALE KA N V E L GLA LA E DEI DY LVKS F - N D LG R N P HD VEL MMF AQ A NSEH C RH KI F NASWD IDGQ AQE K S LF G M I K N 241
Cdd:PLN03206 161 EE GRAALE EI N K E M GLA FD E QDL DY YTRL F r D D IK R D P TN VEL FDI AQ S NSEH S RH WF F SGKLV IDGQ PMP K T LF Q M V K D 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 242 T YEMHREGVLSAY KDN A S V I E G STAGRFF P --------- D PV T R QY gatqepv H IL MKV ETHN H P T A I AP F PGA S TG S GG 312
Cdd:PLN03206 241 T LKANPNNSVIGF KDN S S A I R G FVVQPLR P vspgspspl A PV D R DL ------- D IL LTA ETHN F P C A V AP Y PGA E TG A GG 313
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 313 E IRD EG ATGRG AKPK AG LT G FT V S NL Q I P G FEQ PWE KP - YGK P ERIVT PL D I M I EGPL G GAAFN N E FG R P ALT GY F RTF E 391
Cdd:PLN03206 314 R IRD TH ATGRG SFVV AG TA G YC V G NL R I E G SYA PWE DS s FVY P SNLAS PL Q I L I DASN G ASDYG N K FG E P LIQ GY T RTF G 393
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 392 QAI dt P H GE E v R GYH KPIM LA GG M G N I RAE H VQ KGE IS IG AKLIVL GGPA ML IG L GGGAASSM AT G SSS A D LDF AS VQR D 471
Cdd:PLN03206 394 MRL -- P N GE R - R EWL KPIM FS GG I G Q I DHT H LT KGE PD IG MLVVKI GGPA YR IG M GGGAASSM VS G QND A E LDF NA VQR G 470
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 472 NP EM ERRCQE V IDR C WQQ G A DNPI KF IHD V GAGG IS N ALP E L I ND gg R G GRFEL RAV PNDEPGM S P LEIW CN E S QE RYV L 551
Cdd:PLN03206 471 DA EM SQKLYR V VRA C VEM G E DNPI VS IHD Q GAGG NC N VVK E I I YP -- K G AEIDI RAV VVGDHTL S V LEIW GA E Y QE QDA L 548
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 552 SVDAADFERFKA IC E RERC PF AV V G EAIAEPHLTVN DS HFGN K ----------- AVD MP LE VL LG KP P RMHRSVS R E A EL 620
Cdd:PLN03206 549 LIKPESRDLLQS IC D RERC SM AV I G TIDGSGRVVLV DS AAPE K ceanglppppp AVD LD LE KV LG DM P QKTFEFK R V A NK 628
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 621 IDDFA - AAELD V E DA VN RVL NH P A V A SK N FL I T IG DR TI TGLVA RD Q M VGP W Q V P V AD C AV T A TSFDVY TG E A M A M GE RT 699
Cdd:PLN03206 629 LEPLD i PPGIT V M DA LK RVL RL P S V C SK R FL T T KV DR CV TGLVA QQ Q T VGP L Q I P L AD V AV I A QTHTGL TG G A C A I GE QP 708
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 700 PLA L LNAP A SG R M AVGE TI TNL AAS K IEK LSD I K L S A NWM A AA GHP GE D A RL YD TVK A vgme L CP A --- LG IT I PV GKDS 776
Cdd:PLN03206 709 IKG L VDPK A MA R L AVGE AL TNL VWA K VTA LSD V K A S G NWM Y AA KLD GE G A DM YD AAV A ---- L RD A mie LG VA I DG GKDS 784
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 777 M SM KTRWQD E gvdk S V TS P LS L IVTGFAPVT DI RQ T L TP Q L R L D k GETD L ILI DLG R G QN RLGGS I LAQ V Y SKL G QQV PD 856
Cdd:PLN03206 785 L SM AAQAGG E ---- V V KA P GN L VISAYVTCP DI TK T V TP D L K L G - DDGV L LHV DLG K G KR RLGGS A LAQ A Y DQI G DDC PD 859
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 857 V DD AED LK AF F AVI Q G L N A DGHLL A Y HD R SDGGL LA T V LEMAFAG H CG LDL yld A L ADNRDGLAAV LF N EELG A V IQ V RQ 936
Cdd:PLN03206 860 L DD VAY LK KA F EAT Q D L I A KRLIS A G HD I SDGGL VV T L LEMAFAG N CG INV --- D L PSSGHSAFET LF A EELG L V LE V SR 936
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 937 DATPE V LAQFS AAG LG dc VA VIGQ PVNGADVAISFN G GAVFGGERRM L QRQ W A ETS YRIQR L RDNAE C AD QE FDT L LEED 1016
Cdd:PLN03206 937 KNLDA V MEKLA AAG VT -- AE VIGQ VTASPLIEVKVD G ATCLSEKTAS L RDM W E ETS FQLEK L QRLES C VA QE KEG L KSRK 1014
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1017 N P gl SV KL A F d VNQDIAAPYIKKGAR P Q VAI L RE Q G V NG QV EMAAAF DR AGF AAI DV H MSD I L A GR V SL E DF K G L V AC GG 1096
Cdd:PLN03206 1015 A P -- TW KL S F - TPAFTDKKIMNATSK P K VAI I RE E G S NG DR EMAAAF YA AGF EPW DV T MSD L L N GR I SL D DF R G I V FV GG 1091
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1097 FSY G DVL GAGE GWA K SI L FN TRARDG FQ A F FE R K D S FSLGVCNGCQ M M S n L HELI PG TEFW ----------- P H FV R N R S 1165
Cdd:PLN03206 1092 FSY A DVL DSAK GWA G SI R FN EPLLQQ FQ E F YN R P D T FSLGVCNGCQ L M A - L LGWV PG PQVG gglgaggdpsq P R FV H N E S 1170
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1166 EQ FE A R VAM V QVQE S SS I F L R GM A GS RMPIAI AHGEG H A E F ES E EA L L E ADL S GCVAM R FV D NH G KV TE T YP A NPNGSP R 1245
Cdd:PLN03206 1171 GR FE C R FTS V TIED S PA I M L K GM E GS TLGVWA AHGEG R A Y F PD E SV L D E VLK S NLAPV R YC D DD G EP TE Q YP F NPNGSP L 1250
1290 1300 1310 1320 1330
....*....|....*....|....*....|....*....|....*....|....*..
gi 512733235 1246 GI TG L T S R DGR VTI MMPHPER V F RAV Q NS W R P D EW Q - ED AG --- W MR MF R NAR V W VD 1298
Cdd:PLN03206 1251 GI AA L C S P DGR HLA MMPHPER C F LMW Q FP W Y P K EW G v DP AG psp W LK MF Q NAR E W CE 1307
PurL1
COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and ...
162-1001
0e+00
Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain is part of the Pathway/BioSystem: Purine biosynthesis
Pssm-ID: 439816 [Multi-domain]
Cd Length: 747
Bit Score: 1028.07
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 162 L G GGR A ALE K AN V ELGLAL AE DE I DY L V K sfn D LGRNP H DVEL M MF A Q AN SEHC RH K IF NA SW didgqaqekslfgmik N 241
Cdd:COG0046 6 L E GGR E ALE E AN R ELGLAL SD DE Y DY I V E --- I LGRNP T DVEL G MF S Q MW SEHC SY K SS NA LL ---------------- K 66
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 242 TYEMHREG VLS AYK DNA S V IEGS tagrffpdpvtrqygatq EPVHILM KVE T HNHP T AI A P FP GA S TG S GG E IRD EG at G 321
Cdd:COG0046 67 SLPTEGPR VLS GPG DNA G V VDIG ------------------ DGLAVVF KVE S HNHP S AI E P YQ GA A TG V GG I IRD IF -- G 126
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 322 R GA K P K AGL TGFTVS NL qipgf E QP W ekpygkperi VT P LD I M I EGPL G G A AFN N E FG R P ALT G YF R TF E Q aidtphgee 401
Cdd:COG0046 127 M GA R P I AGL DSLRFG NL ----- D QP P ---------- AS P RY I L I GVVA G I A DYG N C FG V P TVG G EV R FD E S --------- 182
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 402 vrg Y - HK P IML AGG M G N IRA E H VQ K G - EISI G A K LIVL GGP AMLI G L GG GAAS S MAT G SS S A d LD FAS VQ RDN P E ME R R C 479
Cdd:COG0046 183 --- Y e GN P LVN AGG V G I IRA D H IF K A k APGV G N K VVYV GGP TGRD G I GG ATFA S EEL G ED S E - LD RPA VQ VGD P F ME K R L 258
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 480 Q E V I DRC wqq G ADNP I KF I H D V GAGG I S N A LP E LIND GG R G GRFE L RA VP ND EPGMSP L EIW CN ESQER YV L S V DAADF E 559
Cdd:COG0046 259 I E A I LEL --- G DTGL I VG I Q D M GAGG L S S A SS E MAAK GG L G AEID L DK VP LR EPGMSP Y EIW LS ESQER ML L V V KPEKL E 335
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 560 R F K AI C ER E R C P F AV V GE AIAEPH L T V N ds HF G NKAV D M PL EV L L G KP P RM HR SVS R E A E L IDDFAAAEL D V E D A VN R V L 639
Cdd:COG0046 336 E F E AI F ER W R L P A AV I GE VTDDGR L V V T -- DH G ETVA D L PL DF L A G GA P KY HR PAK R P A Y L EPLDLPEPI D L E E A LL R L L 413
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 640 NH P A VASK NF L ITIG DR TIT G LVA RD Q mvgpwqv P VAD C AV TATS f DV Y T G E AM AM GE RTPL ALL NAP A SG RMAV G E TIT 719
Cdd:COG0046 414 SS P N VASK EW L YRQY DR EVG G NTV RD P ------- G VAD A AV VRVD - GT Y K G L AM ST GE NPRY ALL DPY A GA RMAV A E AAR 485
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 720 NLAA SKI E K L s D I KLSA NW MAAA g H P G E D A R L YDT VK AVG m EL C P ALGI TI P V G KD S MSMK T R wqdegv D KS V TS P LSLI 799
Cdd:COG0046 486 NLAA VGA E P L - A I TDCL NW GNPE - K P E E M A Q L VEA VK GLA - DA C R ALGI PV P S G NV S LYNE T K ------ D GK V AI P PTPV 556
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 800 VTGFAP V T D I R Q T L TP Q L RLD kg ETD L I LI dl G RGQ N R LGGS IL AQV YSK LG QQV PDV d D A E DL KA F F AVI Q G L NAD G HL 879
Cdd:COG0046 557 IGAVGL V D D V R K T V TP D L KKE -- GDL L Y LI -- G ETK N E LGGS EY AQV LGQ LG GEP PDV - D L E AE KA L F EAV Q E L IRE G LI 631
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 880 LA Y HD R SDGGL LATVL EMAFAG HC G L D LY LDAL A D N R D gl A A V LF N E EL G - AV I QV RQDATPE V L A QFSA AGL gd CVA VI 958
Cdd:COG0046 632 LA A HD V SDGGL AVALA EMAFAG GL G A D ID LDAL G D L R P -- D A A LF S E SQ G r AV V QV APEDAEA V E A LLAE AGL -- PAH VI 707
810 820 830 840
....*....|....*....|....*....|....*....|...
gi 512733235 959 G QPVNGADVA I SFN G GAVFGGERRM L QRQ W A ET syr IQ RLRDN 1001
Cdd:COG0046 708 G TVTGDDRLV I RRG G ETLLSLSLAE L RDA W E ET --- LP RLRDN 747
GATase_5
pfam13507 CobB/CobQ-like glutamine amidotransferase domain; This family captures members that are not ...
1042-1297
4.17e-150
CobB/CobQ-like glutamine amidotransferase domain; This family captures members that are not found in pfam00310, pfam07685 and pfam13230.
Pssm-ID: 463904 [Multi-domain]
Cd Length: 260
Bit Score: 452.72
E-value: 4.17e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1042 R P Q VAILRE Q G V NG QV EMAAAF D RAGF A A I DVHMSD I L A GRVSL E DF K GL V A C GGFSYGDVLG A G E GWA K SILFN TRA RD 1121
Cdd:pfam13507 1 K P R VAILRE P G T NG EY EMAAAF E RAGF D A V DVHMSD L L S GRVSL D DF Q GL A A P GGFSYGDVLG S G K GWA A SILFN PKL RD 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1122 G F Q AFF E R K D S FSLG V CNGCQ MM S N L H e LIPG T E F ----- WP HFV RN R S EQ FE A R VAM V QV - QE S S S I FLRGM A GS RM P i 1195
Cdd:pfam13507 81 A F E AFF N R P D T FSLG I CNGCQ LL S K L G - LIPG G E G dlaer WP TLT RN D S GR FE S R WVN V KI s EK S P S V FLRGM D GS GL P - 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1196 a I AHGEG HAE F E SEE A L LEADLS G C VA M R F VDN H G KV TE T YP A NPNGSP R GI T G LT S R DGRV TIM MPHPERVFR AV Q NS - 1274
Cdd:pfam13507 159 - V AHGEG RFV F R SEE V L ARLEAN G Q VA L R Y VDN A G NP TE E YP F NPNGSP L GI A G IC S P DGRV LGL MPHPERVFR PW Q WP h 237
250 260
....*....|....*....|...
gi 512733235 1275 W R P D EW Q E DAG W M R M FRNAR V WV 1297
Cdd:pfam13507 238 W P P G EW E E VSP W L R L FRNAR K WV 260
PurL_repeat1
cd02203 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. ...
203-598
1.28e-129
PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100034 [Multi-domain]
Cd Length: 313
Bit Score: 401.08
E-value: 1.28e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 203 EL M MFAQ AN SEHCRHK I F naswdidgqaqe KSL FG MI kntyemhregvlsaykdnasviegstagrffpdpvtrqygatq 282
Cdd:cd02203 1 EL G MFAQ MW SEHCRHK S F ------------ KSL LK MI ------------------------------------------- 25
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 283 ep VHILM KVETHNHP T AI A PF P GA S TG S GG E IRD EGAT G rg A K P K A G L T G FTVSN L Q IPG F E qpwekpygk P ERIVT P LD 362
Cdd:cd02203 26 -- WAVVF KVETHNHP S AI E PF G GA A TG V GG I IRD ILSM G -- A R P I A L L D G LRFGD L D IPG Y E --------- P KGKLS P RR 92
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 363 I MIEGPL G GAAFN N EF G R P ALT G YF R TFE qaidtphgeev RG Y HK P IMLA G GM G NIRAE H VQ K G - EISI G AKLIVL GG PA 441
Cdd:cd02203 93 I LDGVVA G ISDYG N CI G I P TVG G EV R FDP ----------- SY Y GN P LVNV G CV G IVPKD H IV K S k APGP G DLVVLV GG RT 161
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 442 MLI G L GG GAA SS MATGSS S AD LD FAS VQ RDN P E ME RRC QE V I DRCWQ qga DNP I KF I H D V GAGG I S N A LP E LIND GG R G G 521
Cdd:cd02203 162 GRD G I GG ATF SS KELSEN S SE LD RPA VQ VGD P F ME KKL QE A I LEARE --- TGL I VG I Q D L GAGG L S S A VS E MAAK GG L G A 238
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 512733235 522 RFE L RA VP ND EPGMSP L EIW CN ESQER YV L S V DAA D F E R F K AIC ER E RCPF AV V GE AIAEPH L TVNDS hf G NKAV D M 598
Cdd:cd02203 239 EID L DK VP LR EPGMSP W EIW IS ESQER ML L V V PPE D L E E F L AIC KK E DLEA AV I GE VTDDGR L RLYYK -- G EVVA D L 313
PurL2
COG0047 Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain ...
1043-1297
2.77e-112
Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain [Nucleotide transport and metabolism]; Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain is part of the Pathway/BioSystem: Purine biosynthesis
Pssm-ID: 439817 [Multi-domain]
Cd Length: 236
Bit Score: 351.28
E-value: 2.77e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1043 P Q VAIL REQ G V N GQVE MAAAF D RAG FA A I DV HM SD I lag R VS L E DF K GLV AC GGFSYGD V L G AG EGW A K S ilfnt RAR D G 1122
Cdd:COG0047 1 P K VAIL VFP G S N CDRD MAAAF E RAG AE A E DV WH SD L --- R TD L D DF D GLV LP GGFSYGD Y L R AG AIA A F S ----- PIM D A 72
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1123 FQA F F e R KDSFS LG V CNG C Q MMSN L H e L I PG te F WP HFV RNRS EQ F EA R VAMVQ V QESS S I F LR GM - AG SRM PI A IAHGE 1201
Cdd:COG0047 73 VRE F A - R RGGLV LG I CNG F Q ILTE L G - L L PG -- I WP ALT RNRS LR F IC R WVYLR V ENND S P F TS GM e AG EVI PI P IAHGE 148
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1202 G HAEF e S EE A L L E ADLS G C VA M R F VD NH G K VT et YPANPNGS PRG I T G L T SR DG R V TI MMPHPER VFRAVQNS wrpdew Q 1281
Cdd:COG0047 149 G RYVA - D EE T L A E LEAN G Q VA F R Y VD AD G N VT -- YPANPNGS LNN I A G I T NE DG N V LG MMPHPER AVEPLLGP ------ G 219
250
....*....|....*.
gi 512733235 1282 E DAGWM R M FR N A RVWV 1297
Cdd:COG0047 220 E STDGL R I FR S A VKYF 235
PurL
cd02193 Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent ...
286-578
5.19e-104
Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100029 [Multi-domain]
Cd Length: 272
Bit Score: 330.80
E-value: 5.19e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 286 HIL MK V E T HNHP T AI A P FP GA S TG S GG E IRD EG ATG RG AKP K A GLTGFTV S NLQI pgfeqpwekpygkperiv TPLD I MI 365
Cdd:cd02193 2 GEA MK I E E HNHP A AI D P AA GA A TG V GG A IRD IA ATG ID AKP I A LSANWMA S AGHP ------------------ GEDA I LY 63
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 366 EGPL G G A AFN N EF G R P ALT G YF R TFEQAIDTPHG E EVRGY H K P IMLAGGM G NI R AEHVQK - GEISI G AK L IVL GG PAMLI 444
Cdd:cd02193 64 DAVK G V A ELC N QL G L P IPV G KD R MSMKTRWQEGN E QREMT H P P SLVISAF G RV R DDRHTL p QLSTE G NA L LLI GG GKGHN 143
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 445 GLGG G A AS S M A T gs S SAD L DFA S V Q RDN P EM E RRCQ E VIDRCWQQ G adn PIKFI HD V GAGG ISN AL P EL IND G GR G GRFE 524
Cdd:cd02193 144 GLGG T A LA S V A L -- S YRQ L GDK S A Q VRD P AQ E KGFY E AMQALVAA G --- KLLAW HD R GAGG LLV AL A EL VFA G HC G VQVD 218
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 512733235 525 L R A VPN DEP G M S PLEI WCN ESQER Y V LS V D A A D FERFKAICERERCPFA V V G E A 578
Cdd:cd02193 219 L A A LGD DEP D M E PLEI ALF ESQER G V IQ V R A E D RDAVEEAQYGLADCVH V L G Q A 272
GATase1_FGAR_AT
cd01740 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ...
1045-1294
6.33e-91
Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase (FGAR-AT). FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, Pi, and glutamate in the fourth step of the purine biosynthetic pathway. FGAR-AT is a glutamine amidotransferase. Glutamine amidotransferase activity catalyses the transfer of ammonia from the amide side chain of glutamine to an acceptor substrate. FGAR-AT belongs to the triad family of amidotransferases having a conserved Cys-His-Glu catalytic triad in the glutaminase active site
Pssm-ID: 153211 [Multi-domain]
Cd Length: 238
Bit Score: 293.37
E-value: 6.33e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1045 VA I LR EQ G V N GQVE MA A AF DR AGF A A I DV HMS D I LAGR VS L E D FK G L V AC GGFSYGD V L G AG EGW A K S I L FNT rardg FQ 1124
Cdd:cd01740 1 VA V LR FP G S N CDRD MA Y AF EL AGF E A E DV WHN D L LAGR KD L D D YD G V V LP GGFSYGD Y L R AG AIA A A S P L LME ----- EV 75
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1125 AF F ERKDSFS LG V CNG C Q MMSN L HE L IPGTEFWPHFVRNRSE Q F ea R VAMVQ V QESS S I F LR G - M A G SRMP I AI AHGEG H 1203
Cdd:cd01740 76 KE F AERGGLV LG I CNG F Q ILVE L GL L PGALIRNKGLKFICRW Q N -- R FVTLR V ENND S P F TK G y M E G EVLR I PV AHGEG R 153
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1204 AEF e SE E A L L E ADLS G CV A m RF VD NH G K VTE T YPANPNGS PR GI T G LTSR DGRV TI MMPHPER VFRAV Q NS wrpd EWQED 1283
Cdd:cd01740 154 FYA - DD E T L A E LEEN G QI A - QY VD DD G N VTE R YPANPNGS LD GI A G ICNE DGRV LG MMPHPER AVEPW Q WE ---- RLLGG 227
250
....*....|.
gi 512733235 1284 AGWMRM FRNA R 1294
Cdd:cd01740 228 SDGLKL FRNA V 238
PurL_repeat2
cd02204 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. ...
677-960
7.27e-77
PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100035 [Multi-domain]
Cd Length: 264
Bit Score: 255.15
E-value: 7.27e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 677 D C AV TATSFDVYT G E AM AM GE RTPLA LL NAP A SGRM AV G E TIT NL A A SKIEK L s D I KLSA N WMAAAGHP GE DAR L YDT V K 756
Cdd:cd02204 1 D A AV LRIPGETDK G L AM ST GE NPRYS LL DPY A GAAL AV A E AVR NL V A VGADP L - A I TDCL N FGNPEKPE GE MGQ L VEA V L 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 757 AV G m EL C P ALG ITIPV GKDS MSMK T RW qdegvdks V TS P LS L IVTGFAP V T D I R QTL T PQLR ld K GETD L I LI DLGRGQN 836
Cdd:cd02204 80 GL G - DA C R ALG TPVIG GKDS LYNE T EG -------- V AI P PT L VIGAVGV V D D V R KIV T LDFK -- K EGDL L Y LI GETKDEL 148
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 837 RLGGSI LA qv Y SK LG QQV P DVD D A E DL KA F F AVI Q G L NAD G HL L AY HD R SDGGL LATVL EMAFAG HC G LDLY L DALADN r 916
Cdd:cd02204 149 GGSEYA LA -- Y HG LG GGA P PLV D L E RE KA L F DAV Q E L IKE G LV L SA HD V SDGGL AVALA EMAFAG GL G AEVD L SKDDAE - 225
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 512733235 917 dgl AAV LF N E E LG A V IQV rqd AT PE VLAQ F S A AGL G DCVA VIG Q 960
Cdd:cd02204 226 --- DEL LF S E S LG R V LVE --- VK PE NEEV F E A EEA G VPAT VIG T 263
PHA03366
PHA03366 FGAM-synthase; Provisional
558-1296
4.54e-74
FGAM-synthase; Provisional
Pssm-ID: 223058 [Multi-domain]
Cd Length: 1304
Bit Score: 270.74
E-value: 4.54e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 558 FERF K AI C ERER CP FAVV G EAIAE P HLTVNDSHFGNKAVD --------- M PL EVLLGKP P R m HRSVS -- R EAELIDDFAA 626
Cdd:PHA03366 507 LDAL K RA C RLAG CP VHIL G RTVPL P GIHFVNDLGNPVYGE lrddqfkpt F PL QPSRPLS P V - SATSE dt R PSPQDESIDW 585
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 627 A ELDVEDAVNRV L N HP A V A SK NFLITIG DR TIT G L VA RDQM VGP WQV PV A D CAVTAT S ---------------------- 684
Cdd:PHA03366 586 A LFNLNSTLLQI L S HP T V G SK EYIVRHI DR CGN G R VA QQPG VGP LDL PV S D YSIVVH S svktrraietpsstedltyqea 665
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 685 ------------ F D VYT ------- G EAM A M GE RTPLAL L NAPASGRM A VG E TI TNL AASKIEK L S DI KLSAN -- W MAAAG 743
Cdd:PHA03366 666 delinspltwfd P D DES vlhpavp G TCS A L GE QGYKVQ L DPILGAKY A IV E AL TNL MLAPVAN L E DI TITLS vt W PPTDQ 745
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 744 HPG E dar LY DTVK A V g M E L C PA LG ITIPVG kd S M S MKT R WQDEGVD ksv TSPLSL IV - T GF APV TDIRQT LTP Q L R ld K G 822
Cdd:PHA03366 746 AAS E --- LY RALA A C - K E F C RE LG VNFTFT -- S A S SSP R QDQPPQP --- GPLFNT IV f T AS APV PSSTPR LTP D L K -- K P 814
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 823 ETD L ILIDLGRGQN r L G GS ILA Q VYSKLGQQV PD VD d AED LK AF F AVI Q G L NAD G HLLAY HD R SDGGL L A TVL EMA F AG H 902
Cdd:PHA03366 815 GSA L VHLSISPEYT - L A GS VFE Q IFGLKSGTL PD IS - PSY LK NL F RAV Q H L ISE G LVVSG HD V SDGGL I A CLA EMA L AG G 892
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 903 C G LDLYLD A LA D N rdgl AAV LF N E EL G A VI Q V RQDATPE VL AQFSAAGL gd CVAV IG QPVN --- GADVAI S F NG GAV F GG 979
Cdd:PHA03366 893 R G VTITVP A GE D P ---- LQF LF S E TP G V VI E V PPSHLSA VL TRLRSRNI -- ICYP IG TVGP sgp SNTFSV S H NG TVL F RE 966
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 980 ERRM L QRQ W AET S YRIQR L R dnae CA D QEFDTLLEE D ------- NPG L SVK L AFDVNQDIAA P YI kkga R PQ VA I L REQ G 1052
Cdd:PHA03366 967 SLSS L RST W RSF S DEQFE L L ---- RP D LTEESMYRK D ygnnevd LGP L EEG L TTSPLRLYTC P DK ---- R HR VA V L LLP G 1038
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1053 VN G QVEMA AAF DR AGF AAID V HMSDILA G R v S L ED F K GLV AC G GFSYG D VLGAGEGWAKSI L F N TRA RD GFQA F FE R K D S 1132
Cdd:PHA03366 1039 CP G PHALL AAF TN AGF DPYP V SIEELKD G T - F L DE F S GLV IG G SSGAE D SYTGARAAVAAL L S N PAV RD ALLR F LN R P D T 1117
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1133 FSLG VCN - GCQ MMSN L ---------- HELIPGT E F WP - HFVR N R S EQF E A R VAMVQVQ E SS - S IF LR GMA GS RM P i AI A H 1199
Cdd:PHA03366 1118 FSLG CGE l GCQ ILFA L kavgstapsp VPGTETE E Q WP i TLEP N A S GLY E S R WLNFYIP E TT k S VA LR PLR GS VL P - CW A Q 1196
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1200 G E ---- GHAEFES E EA L LE adl SG CV A MR F vdn HG KVT ------ ET YP A NP N G - S P rg IT GL T S R DGR VTIMMPH P ERV F 1268
Cdd:PHA03366 1197 G T hlgf RYPNDGM E YI L RN --- SG QI A AT F --- HG ADV dpgnpa RH YP R NP T G n S N -- VA GL C S A DGR HLALLFD P SLS F 1268
810 820 830
....*....|....*....|....*....|....*..
gi 512733235 1269 ravq NS W rpd E WQ EDAG --------- W MR MF RNARV W 1296
Cdd:PHA03366 1269 ---- HP W --- Q WQ HVPP engplkvsp W KL MF QDLHL W 1298
FGAM_synth_II
TIGR01736 phosphoribosylformylglycinamidine synthase II; Phosphoribosylformylglycinamidine synthase is a ...
180-976
4.58e-72
phosphoribosylformylglycinamidine synthase II; Phosphoribosylformylglycinamidine synthase is a single, long polypeptide in most Proteobacteria and eukarotes. Three proteins are required in Bacillus subtilis and many other species. This is the longest of the three and is designated PurL, phosphoribosylformylglycinamidine synthase II, or FGAM synthase II. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 273781 [Multi-domain]
Cd Length: 715
Bit Score: 256.07
E-value: 4.58e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 180 L AED E IDYLVKS fnd LGR N P H D V EL M MF AQAN SEHC RH K ifnaswdidgqa QE K S L F gmik NTYEMHREG V LSAYKDN A S 259
Cdd:TIGR01736 1 L SDE E MELIREI --- LGR E P N D T EL A MF SAMW SEHC SY K ------------ SS K K L L ---- KQFPTKGPN V IQGPGED A G 61
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 260 V IE gstagrf FP D pvtr Q Y GAT qepvhil M K V E T HNHP T AI A P FP GA S TG S GG EI RD eg ATGR GA K P K A G L TGFTVSN L Q 339
Cdd:TIGR01736 62 V VD ------- IG D ---- G Y AVV ------- F K M E S HNHP S AI E P YN GA A TG V GG IL RD -- ILSM GA R P I A L L DSLRFGP L D 121
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 340 I P gfeqpwekpyg K PERIV tpldimi EG PLG G - AAFN N EF G R P ALT G yfrtf E QAI D tphgeev RG Y H - K P IMLAGGM G N 417
Cdd:TIGR01736 122 D P ----------- K NRYLF ------- EG VVA G i SDYG N RI G V P TVG G ----- E VEF D ------- ES Y N g N P LVNVMCV G L 171
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 418 I R AEHVQK G EI - SI G A KL IVL GG PAMLI G L GG GAAS S MATGSSSADL D FAS VQ RDN P EM E RR ---- CQ E VI D R cwqqgad 492
Cdd:TIGR01736 172 V R KDDIVT G KA k GP G N KL VLV GG KTGRD G I GG ATFA S EELSEEAEEE D RPA VQ VGD P FT E KL liea TL E AV D T ------- 244
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 493 NPI K F I H D V GA G G ISN A LP E LIND GG R G GRFE L RA VP ND EPGM S P L EI WCN ESQER YV L S V DAA D F E RFKA I C E RERC P F 572
Cdd:TIGR01736 245 GLV K G I K D L GA A G LTS A SS E MAAK GG L G AEIY L DK VP LR EPGM T P Y EI MLS ESQER ML L V V APE D V E EVLE I F E KYEL P A 324
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 573 A V V GE AIA E PHLTV nd SHF G NKAV D M P L E v LL GKP P RMH R S v S REAELIDDFAAA E L -- D V EDA VNR VL NH P AV ASK NFL 650
Cdd:TIGR01736 325 S V I GE VTD E GRIRL -- YYK G EVVA D L P I E - LL ADA P EYE R P - S EPPKYPEEEKEP E P pa D L EDA FLK VL SS P NI ASK EWV 400
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 651 I ----- TIGD RT I tglvardqmvgpw QV P VA D C AV TATSFDVYT G E A MAMGERTPLAL L NAP A SGRM AV G E TIT NLAA SK 725
Cdd:TIGR01736 401 Y rqydh EVQT RT V ------------- VK P GE D A AV LRIKETGKL G L A LTADCNPRYVY L DPY A GAAG AV A E AYR NLAA VG 467
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 726 I E K L S d IKLSA N W maaa G H P g E DARL Y ---- DT VK AV G m EL C P ALG ITIPV G KD S M smktrw QD E GVDKSVTSPLSLIVT 801
Cdd:TIGR01736 468 A E P L A - AVDCL N F ---- G N P - E RPEV Y wqfv EA VK GL G - DA C R ALG TPVVG G NV S L ------ YN E TNGVPIAPTPTIGMV 534
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 802 G F ap V T D IRQT LT PQL rld K G E T D L I LI d L G RGQNR LGGS - I L AQVYSKLGQ QVP D VD DA E DLKAFF AV I q GLNAD G HLL 880
Cdd:TIGR01736 535 G L -- V E D VEKL LT SNF --- K K E G D A I YL - I G ETKDE LGGS e Y L RVIHGIVSG QVP A VD LE E EKELAD AV R - EAIRA G LVS 607
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 881 A Y HD R S D GGL LATVL EMA F A GHC G LDLYL D AL A DN R D gl AAV LF N E EL G AV I Q vrqd A T PE VL A QFSAAGL G DCVA VIG Q 960
Cdd:TIGR01736 608 A A HD V S R GGL AVALA EMA A A SGI G AEVDI D EI A SA R P -- DEL LF S E SN G RA I V ---- A V PE EK A EEAVKSK G VPAK VIG K 681
810
....*....|....*.
gi 512733235 961 p VN G ADVA I SFNGGAV 976
Cdd:TIGR01736 682 - TG G DRLT I KTGDDTI 696
FGAM-synthase
TIGR01857 phosphoribosylformylglycinamidine synthase, clade II; This model represents a single-molecule ...
111-1266
1.40e-69
phosphoribosylformylglycinamidine synthase, clade II; This model represents a single-molecule form of phosphoribosylformylglycinamidine synthase, also called FGAM synthase, an enzyme of purine de novo biosynthesis. This model represents a second clade of these enzymes found in Clostridia, Bifidobacteria and Streptococcus species. This enzyme performs the fourth step in IMP biosynthesis (the precursor of all purines) from PRPP. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 130916 [Multi-domain]
Cd Length: 1239
Bit Score: 256.31
E-value: 1.40e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 111 Y YVA G AIS D ADAEA I AA - VLHDRMTQLVLPGLEE A AGL FS HAQPKPL T VVDILGGGRAA L E K ANV E L GLA LAEDEIDYLV 189
Cdd:TIGR01857 117 Y ILN G DLD D EELNK I KN y YINPVDSREKDLTTGK A LEE FS ESPKEVE T LTGFESYDAED L A K FKA E Q GLA MSLEDLKFIQ 196
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 190 KS F NDL GRNP HDV E LMMFAQAN S E HCRH KI F NA sw DIDGQAQEK S L F G - MI K NT YE MH --- RE GVLSAY K DNASVIEGST 265
Cdd:TIGR01857 197 DY F KSI GRNP TET E IKVLDTYW S D HCRH TT F ET -- ELKHVTFSD S K F Q k QL K KA YE DY lam RE ELGRSE K PVTLMDMATI 274
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 266 AGRFFPD ------- P V TRQYG A T ----------- Q EP VHILM K V ETHNHPT A I A PF P GA S T GS GG E IRD egatgrgak P K 327
Cdd:TIGR01857 275 FAKYLRK ngklddl E V SEEIN A C sveievdvdgv K EP WLLMF K N ETHNHPT E I E PF G GA A T CI GG A IRD --------- P L 345
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 328 A G LT g FTVSNLQIP G FEQ P W ---- E KPY GK - P E R IV T pldim IEGPL G GAAFN N EF G rp AL TG YFRTFEQA idtphgeev 402
Cdd:TIGR01857 346 S G RS - YVYQAMRVT G AGD P T vpis E TLK GK l P Q R KI T ----- TTAAH G YSSYG N QI G -- LA TG QVSEIYHP --------- 408
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 403 r GY HKPI M LA G G - MGNIRA E H V QKGEISI G AKL I V LGG PAMLI G L GG GAA SS MATGSS S AD L DF A S VQ RD N PEM ER RC Q e 481
Cdd:TIGR01857 409 - GY VAKR M EV G A v VAATPK E N V VREKPEP G DVI I L LGG KTGRD G I GG ATG SS KEHTVE S LE L CG A E VQ KG N APE ER KI Q - 486
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 482 vid R CWQQ G - ADNP IK FIH D V GAGG I S N A LP EL indg GR G GRFE L RA VP NDEP G MSPL E IWCN ESQER YVLS V DAA D FER 560
Cdd:TIGR01857 487 --- R LFRN G n VTRL IK KCN D F GAGG V S V A IG EL ---- AD G LEID L NK VP KKYE G LNGT E LAIS ESQER MAVV V SPE D VDA 559
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 561 F K A I C ER E RCPFA VV GEAIAE P H L TV N DS hf G NKA VD MPLEV L LGKPP R MHRSV --- SREAE L - IDDFAAAELDV E DAVN 636
Cdd:TIGR01857 560 F L A Y C NE E NLEAT VV ATVTEK P R L VM N WN -- G KTI VD LSRRF L DTNGV R QVIDA kvv DKDVK L p EERQKTSAETL E EDWL 637
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 637 R VL NHPA VAS KNF L ITIG D RTITGLVARDQMV G PW Q VPVAD ca VTATSFD V YT GE ----- A M A M G ERTPL A LLNAPASGR 711
Cdd:TIGR01857 638 K VL SDLN VAS QKG L QERF D SSVGAGTVLMPLG G KY Q LTPTE -- ASVAKLP V LG GE thtas A I A W G FNPYI A EWSPYHGAA 715
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 712 M AV G E TITN L A A SKI ------------- EKL S di K LSAN W maaa G H P G ed A R L YDTV KA v GME L - C PA L G itipv GKDSM 777
Cdd:TIGR01857 716 Y AV I E SLAK L V A AGA dykkarlsfqeyf EKL D -- K DAER W ---- G K P F -- A A L LGAI KA - QID L g L PA I G ----- GKDSM 781
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 778 S mktrwqde G VDKSV T S P LS LI VTGFA p VTDI R QTLT P QLR l DK GE T dlil I D L GR GQ NRLG G S I laqvysklgqqvpdv 857
Cdd:TIGR01857 782 S -------- G TFEEL T V P PT LI SFAVT - TANS R RVIS P EFK - AA GE N ---- I Y L IP GQ ALED G T I --------------- 832
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 858 d D AED LK AF FA V I QG L N AD GHLLAYHDRSD GG LLATVLE M A F AGHC G LD L YLDA L A D nrdglaav LF NEEL G AV I Q vrqd 937
Cdd:TIGR01857 833 - D FDL LK EN FA Q I EE L I AD HKVVSASAVKY GG VAESLAK M T F GNRI G AE L NNPE L E D -------- LF TAQY G SF I F ---- 899
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 938 atp E VLAQF S A A GLG dcva V IGQ PV ng AD VAISF NG GAVFGG E rrm L QRQ W AETSYRI qrlrdnaecadqe F DTLL E EDN 1017
Cdd:TIGR01857 900 --- E SPEEL S I A NVE ---- K IGQ TT -- AD FVLKV NG EKLDLE E --- L ESA W EGKLEEV ------------- F PSKF E DKK 954
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1018 PGLS V K laf D V NQDIAAPYI K - K GAR P Q V A I LREQ G V N GQVEM A A AF DRA G FAAID V HMSDILAGRV -- S L E DFKG ---- 1090
Cdd:TIGR01857 955 ETVE V P --- A V ASEKKVIKA K e K VEK P R V V I PVFP G T N SEYDS A K AF EKE G AEVNL V IFRNLNEEAL ve S V E TMVD eidk 1031
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1091 --- L VAC GGFS Y GD vlg AGE G W AK --- S IL F N TRA R DGFQA F FE R k D SFS LG V CNG C Q MMSNL ----- HELIPGT E FW P H 1159
Cdd:TIGR01857 1032 sqi L MLP GGFS A GD --- EPD G S AK fia A IL R N PKV R VAIDS F LA R - D GLI LG I CNG F Q ALVKS gllpy GNIEAAN E TS P T 1107
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1160 FVR N RSEQFEARVAMVQVQESS S IF L R G MA - G SRMP I AIA HGEG HA e FE S E E A L L E ADLS G CV A MRF VD NH GK VTETYPA 1238
Cdd:TIGR01857 1108 LTY N DINRHVSKIVRTRIASTN S PW L S G VS v G DIHA I PVS HGEG RF - VA S D E V L A E LREN G QI A TQY VD FN GK PSMDSKY 1186
1210 1220
....*....|....*....|....*...
gi 512733235 1239 NPNGS PRG I T G L TS R DGR VTIM M P H P ER 1266
Cdd:TIGR01857 1187 NPNGS SLA I E G I TS P DGR IFGK M G H S ER 1214
PRK01213
PRK01213 phosphoribosylformylglycinamidine synthase subunit PurL;
178-976
1.03e-64
phosphoribosylformylglycinamidine synthase subunit PurL;
Pssm-ID: 234921 [Multi-domain]
Cd Length: 724
Bit Score: 234.61
E-value: 1.03e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 178 LA L AE DE IDYLVKS fnd LGR N P HDV EL M MF AQAN SEHC RH K ifn A S wdidgqaqe K S L F gmik NTYEMHREG VL SAYKD N 257
Cdd:PRK01213 11 MG L TD DE YERIREI --- LGR E P NFT EL G MF SVMW SEHC SY K --- S S --------- K P L L ---- RKFPTKGPR VL QGPGE N 71
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 258 A S V IE gstagrffpdp VTRQYGAT qepvhil M K V E T HNHP T A IA P FP GA S TG S GG EI RD EGAT G rg A K P K A G L tgftv SN 337
Cdd:PRK01213 72 A G V VD ----------- IGDGQAVV ------- F K I E S HNHP S A VE P YQ GA A TG V GG IL RD IFSM G -- A R P I A L L ----- DS 126
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 338 L QIPGFEQ P wekpyg K PERIV tpldimi EG PLG G - AAFN N EF G R P ALT G yfrtfeqaidtphge EV R --- G Y HK - P IML A 412
Cdd:PRK01213 127 L RFGELDH P ------ K TRYLL ------- EG VVA G i GGYG N CI G V P TVG G --------------- EV Y fde S Y NG n P LVN A 178
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 413 GGM G NI R AEHVQKGEI S - I G AKLIVL G GPAMLI G L GG gaa S S M A tgss SA D L DFA S ------ VQ RDN P E ME RR ---- C Q E 481
Cdd:PRK01213 179 MCV G LV R HDDIVLAKA S g V G NPVVYV G AKTGRD G I GG --- A S F A ---- SA E L SEE S eekrpa VQ VGD P F ME KL liea C L E 251
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 482 V I DR cwqq G A dnp IKF I H D V GA G G ISNALP E LIND GG R G GRFE L RA VP ND E P GM S P L EI WCN ESQER YV L S V DAADF E RF 561
Cdd:PRK01213 252 L I KT ---- G L --- VVG I Q D M GA A G LTCSSS E MAAK GG L G IELD L DK VP LR E E GM T P Y EI MLS ESQER ML L V V KPGKE E EV 324
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 562 K AI C E RERCPF AV V GE AIAEPH L T V nd S H F G NKAV D M P L E V L LGKP P RMH R SVSRE A E L i D DFA A AEL D VED A VNRV L NH 641
Cdd:PRK01213 325 L AI F E KWDLDA AV I GE VTDDGR L R V -- Y H H G EVVA D V P A E A L ADEA P VYD R PYKEP A Y L - D ELQ A DPE D LKE A LLKL L SS 401
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 642 P AV ASK NFLI ----- TIGDR T I tglvardqmvgpw QV P VA D C AV TATS f DVYT G E A MAMGERTPLAL L NAPASGRM AV G E 716
Cdd:PRK01213 402 P NI ASK EWVY eqydh EVQTN T V ------------- VK P GG D A AV LRIR - GGGK G L A LTTDCNPRYVY L DPYEGAKL AV A E 467
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 717 TIT NLAA SKIEK L sdiklsanwma A A ------ G H P GEDARLYDT V K AV - G M - EL C P ALG it I PV -- G KD S MSMK T RWQD - 785
Cdd:PRK01213 468 AAR NLAA VGATP L ----------- A I tdclnf G N P EKPEVMWQF V E AV r G L a DA C R ALG -- T PV vg G NV S LYNE T GGTA i 534
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 786 ------------ EG V D K SV TS plslivt GF apvtdirqtltpqlrld K G E T DLI LI d LG RGQNR LGGS ILAQ V - YSKL G Q 852
Cdd:PRK01213 535 yptpvigmvgli DD V S K RT TS ------- GF ----------------- K K E G DLI YL - LG ETKDE LGGS EYLK V i HGHV G G 589
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 853 QV P D VD DAED l K AFFAVIQGLNAD G HLLAY HD R S D GGL LATVL EMA F AG HC G LDLY L DALAD nrdg LA A V LF N E EL G - A V 931
Cdd:PRK01213 590 RP P K VD LEAE - K RLQELVREAIRE G LVTSA HD V S E GGL AVALA EMA I AG GL G AEVD L SDGLR ---- PD A L LF S E SQ G r Y V 664
810 820 830 840
....*....|....*....|....*....|....*....|....*
gi 512733235 932 IQ V RQDATPEVL A QFS AAG LG dc VAV IG Q p V N G ADVAISF N GGAV 976
Cdd:PRK01213 665 VS V PPENEEAFE A LAE AAG VP -- ATR IG V - V G G DALKVKG N DTES 706
PurL
cd02193 Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent ...
690-960
4.96e-60
Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100029 [Multi-domain]
Cd Length: 272
Bit Score: 207.53
E-value: 4.96e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 690 GEAM AMG E RTPL A LLNAP A SGRMA VG ET I TNL AA SK I E k LSD I K LSANWMA A AGHPGEDA R LYD T VK A V G m ELC PA LG IT 769
Cdd:cd02193 2 GEAM KIE E HNHP A AIDPA A GAATG VG GA I RDI AA TG I D - AKP I A LSANWMA S AGHPGEDA I LYD A VK G V A - ELC NQ LG LP 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 770 IPVGKD S MSMKTRWQ DEGVDKSV T S P L SL IVTG F AP V T D I R Q TL TPQLRLDKG etd L I LI DL G R G Q N R LGG SI LA Q V --- 846
Cdd:cd02193 80 IPVGKD R MSMKTRWQ EGNEQREM T H P P SL VISA F GR V R D D R H TL PQLSTEGNA --- L L LI GG G K G H N G LGG TA LA S V als 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 847 Y SK LG QQVPD V D D AEDL K A F FAVI Q G L N A D G H LLA Y HDR SD GGLL ATVL E MA FAGHCG LDLY L D AL A D NRDG --- L AAV L 923
Cdd:cd02193 157 Y RQ LG DKSAQ V R D PAQE K G F YEAM Q A L V A A G K LLA W HDR GA GGLL VALA E LV FAGHCG VQVD L A AL G D DEPD mep L EIA L 236
250 260 270
....*....|....*....|....*....|....*..
gi 512733235 924 F NEELGA VIQVR QDATPE V LA qf SAA GL G DCV A V I GQ 960
Cdd:cd02193 237 F ESQERG VIQVR AEDRDA V EE -- AQY GL A DCV H V L GQ 271
FGAR-AT_N
pfam18076 Formylglycinamide ribonucleotide amidotransferase N-terminal; This is the N-terminal domain ...
35-148
1.39e-58
Formylglycinamide ribonucleotide amidotransferase N-terminal; This is the N-terminal domain found in Formylglycinamide ribonucleotide amidotransferase (FGAR-AT), also known as Phosphoribosylformylglycinamidine synthase (EC:6.3.5.3), PurL and formylglycinamidine ribonucleotide (FGAM) synthase. This enzyme catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide and glutamine to formylglycinamidine ribonucleotide, ADP, Pi, and glutamate in the fourth step of the purine biosynthetic pathway.
Pssm-ID: 465635 [Multi-domain]
Cd Length: 115
Bit Score: 196.92
E-value: 1.39e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 35 E FT HF A E VTGV LS GE E EQV L AR LL K YGP SVPVQ EP S G R L F LV V PR V GTISPWSSKATDIA R NCGL AKIE R L ERGIAYY VA 114
Cdd:pfam18076 1 E YV HF V E LEAP LS AA E RAR L EQ LL T YGP PLEEP EP E G E L L LV T PR L GTISPWSSKATDIA H NCGL DAVR R I ERGIAYY LT 80
90 100 110
....*....|....*....|....*....|....*
gi 512733235 115 G - AI S D A DAE A I AA V LHDRMT QL VL PG LE E AA G LF 148
Cdd:pfam18076 81 G k PL S A A ELA A L AA L LHDRMT ES VL TD LE D AA A LF 115
PurM-like
cd00396 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen ...
286-577
2.19e-39
AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain of AIR synthase forms the dimer interface of the protein, and is suggested as a putative ATP binding domain.
Pssm-ID: 100027 [Multi-domain]
Cd Length: 222
Bit Score: 146.00
E-value: 2.19e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 286 HIL M KVETH N H P T AI A P FP G ASTGS GG EIR D EG A T gr GA K P K A G L TGFTV SN L qipgfeqpwekpygkperiv TPL DI MI 365
Cdd:cd00396 1 SLA M STDGI N P P L AI N P WA G GRLAV GG AVN D IA A M -- GA R P I A L L ASLSL SN G -------------------- LEV DI LE 58
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 366 EGPL G G A AFN N EF G R P ALT G YFRTFEQA idtphgeevr GY HK PIMLAGGM G NIRAEH V QKG - EISI G AK LI VL G gpamli 444
Cdd:cd00396 59 DVVD G V A EAC N QL G V P IVG G HTSVSPGT ---------- MG HK LSLAVFAI G VVEKDR V IDS s GARP G DV LI LT G ------ 122
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 445 glgggaassmatgsssadldfasvqrdnpemerrc QEVIDRCWQQ G adn PIKFI HD VGA GG ISNA LPEL INDG G R G GRFE 524
Cdd:cd00396 123 ----------------------------------- VDAVLELVAA G --- DVHAM HD ITD GG LLGT LPEL AQAS G V G AEID 164
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 512733235 525 L R A V P N DE PGMS ----- PL E IWCNE S QERYVLS V D A ADFERFKAICERERCPF AV V G E 577
Cdd:cd00396 165 L E A I P L DE VVRW lcveh IE E ALLFN S SGGLLIA V P A EEADAVLLLLNGNGIDA AV I G R 222
PRK01175
PRK01175 phosphoribosylformylglycinamidine synthase I; Provisional
1043-1285
1.57e-36
phosphoribosylformylglycinamidine synthase I; Provisional
Pssm-ID: 234913 [Multi-domain]
Cd Length: 261
Bit Score: 139.13
E-value: 1.57e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1043 PQ VA I LR EQ G V N GQV E MAA AF D R A G FAAID VH MS D IL A G R V S LE D FKG LV AC GGFS Y GD VLG AG egwaks IL F NT R ARD g 1122
Cdd:PRK01175 4 IR VA V LR ME G T N CED E TVK AF R R L G VEPEY VH IN D LA A E R K S VS D YDC LV IP GGFS A GD YIR AG ------ AI F AA R LKA - 76
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1123 fqaf FE RKD -------- SFSL G V CNG C Q MMSN L HE L IPGT E FWPH ---- FVR N R S EQ FE A R VAMVQVQESSS IF LRGMAG 1190
Cdd:PRK01175 77 ---- VL RKD ieefideg YPII G I CNG F Q VLVE L GL L PGFD E IAEK pema LTV N E S NR FE C R PTYLKKENRKC IF TKLLKK 152
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1191 SRMPIAI AH G EG HAE F ES EE A L LEADLSGCVAM R F VD NH G k VTET YP A NPNGS PRG I T G L T SRD G R V TIM MPHPER V F RA 1270
Cdd:PRK01175 153 DVFQVPV AH A EG RVV F SE EE I L ERLIENDQIVF R Y VD EN G - NYAG YP W NPNGS IYN I A G I T NEK G N V IGL MPHPER A F YG 231
250
....*....|....*
gi 512733235 1271 V Q NSW rp D E WQ ED A G 1285
Cdd:PRK01175 232 Y Q HPY -- W E KE ED Y G 244
AIRS_C
pfam02769 AIR synthase related protein, C-terminal domain; This family includes Hydrogen expression ...
431-586
1.87e-35
AIR synthase related protein, C-terminal domain; This family includes Hydrogen expression/formation protein HypE, AIR synthases EC:6.3.3.1, FGAM synthase EC:6.3.5.3 and selenide, water dikinase EC:2.7.9.3. The function of the C-terminal domain of AIR synthase is unclear, but the cleft formed between N and C domains is postulated as a sulphate binding site.
Pssm-ID: 460684 [Multi-domain]
Cd Length: 152
Bit Score: 132.08
E-value: 1.87e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 431 G AK LI V LG G paml I GL G G GAA S SMAT G SSSAD L df A S VQ RDN P EM E RRCQE V IDRCWQQ G ad NPI K FI HD VGA GG ISN AL 510
Cdd:pfam02769 3 G DV LI L LG S ---- S GL H G AGL S LSRK G LEDSG L -- A A VQ LGD P LL E PTLIY V KLLLAAL G -- GLV K AM HD ITG GG LAG AL 74
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 512733235 511 P E LINDG G R G GRFE L RA VP ND E PG M S PLE IWCN E S Q E R YVLS V DAADF E RFK AI C E R E RCPF AV V GE AI A EPH LTV 586
Cdd:pfam02769 75 A E MAPAS G V G AEID L DK VP IF E EL M L PLE MLLS E N Q G R GLVV V APEEA E AVL AI L E K E GLEA AV I GE VT A GGR LTV 150
FGAM_synth_I
TIGR01737 phosphoribosylformylglycinamidine synthase I; In some species, ...
1045-1274
1.12e-33
phosphoribosylformylglycinamidine synthase I; In some species, phosphoribosylformylglycinamidine synthase is composed of a single polypeptide chain. This model describes the PurQ protein of Bacillus subtilis (where PurL, PurQ, and PurS are required for phosphoribosylformylglycinamidine synthase activity) and functionally equivalent proteins from other bacteria and archaea. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 273782 [Multi-domain]
Cd Length: 227
Bit Score: 129.81
E-value: 1.12e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1045 VA IL R EQ G V N GQVEMAA A FDRA G FA A ID V HMS D ilagr V SL E D FK G L V AC GGFSYGD V L G AG egwak S I LFNTRARDGFQ 1124
Cdd:TIGR01737 3 VA VI R FP G T N CDRDTVY A LRLL G VD A EI V WYE D ----- G SL P D YD G V V LP GGFSYGD Y L R AG ----- A I AAASPIMQEVR 72
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1125 A F F E r K DSFS LG V CNG C Q MMSNL h E L I PG T efwph FVR N R S EQ F EA R VAMVQ V QESSS IF LRGMAGS --- R M PIA ia HGE 1201
Cdd:TIGR01737 73 E F A E - K GVPV LG I CNG F Q ILVEA - G L L PG A ----- LLP N D S LR F IC R WVYLR V ENADT IF TKNYKKG evi R I PIA -- HGE 143
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 512733235 1202 G HAEFE s E E A L LEADLSGC V AM R FV D NH G K V T E ty P ANPNGS PRG I T G LTSRD G R V TI MMPHPER VFRAVQNS 1274
Cdd:TIGR01737 144 G RYYAD - D E T L ARLESNDQ V VF R YC D ED G D V A E -- E ANPNGS VGN I A G IVNER G N V LG MMPHPER ASEKLLGG 213
FGAR-AT_linker
pfam18072 Formylglycinamide ribonucleotide amidotransferase linker domain; This is the linker domain ...
169-218
1.80e-27
Formylglycinamide ribonucleotide amidotransferase linker domain; This is the linker domain found in Formylglycinamide ribonucleotide amidotransferase (FGAR-AT), also known as Phosphoribosylformylglycinamidine synthase (EC:6.3.5.3), PurL and formylglycinamidine ribonucleotide (FGAM) synthase. This enzyme catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, Pi, and glutamate in the fourth step of the purine biosynthetic pathway. The structure analysis of Salmonella typhimurium FGAR-AT reveals that this linker domain is made up of a long hydrophilic belt with an extended conformation.
Pssm-ID: 465632 [Multi-domain]
Cd Length: 50
Bit Score: 105.63
E-value: 1.80e-27
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 512733235 169 LE K AN VE LGLAL AE DEIDYLV KS F ND LGRNP H DVEL M MFAQ AN SEHCRHK 218
Cdd:pfam18072 1 LE E AN RY LGLAL SD DEIDYLV EY F AG LGRNP T DVEL G MFAQ MW SEHCRHK 50
PRK03619
PRK03619 phosphoribosylformylglycinamidine synthase subunit PurQ;
1045-1266
1.74e-24
phosphoribosylformylglycinamidine synthase subunit PurQ;
Pssm-ID: 235140 [Multi-domain]
Cd Length: 219
Bit Score: 102.89
E-value: 1.74e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1045 VA ILREQ G V N GQVE MA A A F - D RA G FAAID V - H MSD ilagrv S L EDFKGL V AC GGFSYGD V L GA G egwak S I LFNTRARDG 1122
Cdd:PRK03619 3 VA VIVFP G S N CDRD MA R A L r D LL G AEPEY V w H KET ------ D L DGVDAV V LP GGFSYGD Y L RC G ----- A I AAFSPIMKA 71
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1123 FQA F F E R k DSFS LG V CNG C Q MMSNLH e L I PG T efwph FV RN R S EQ F EA R VAMVQ V QESSSI F LR G MAGS --- R M PIA ia H 1199
Cdd:PRK03619 72 VKE F A E K - GKPV LG I CNG F Q ILTEAG - L L PG A ----- LT RN A S LK F IC R DVHLR V ENNDTP F TS G YEKG evi R I PIA -- H 142
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 512733235 1200 GEG HA e FES EE A L -- LE AD ls G C V AM R FV D nhgkvtetyp A NPNGS PRG I T G LTSRD G R V TI MMPHPER 1266
Cdd:PRK03619 143 GEG NY - YAD EE T L kr LE GN -- G Q V VF R YC D ---------- E NPNGS VND I A G IVNEK G N V LG MMPHPER 198
PurM-like
cd00396 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen ...
690-960
3.14e-23
AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain of AIR synthase forms the dimer interface of the protein, and is suggested as a putative ATP binding domain.
Pssm-ID: 100027 [Multi-domain]
Cd Length: 222
Bit Score: 99.39
E-value: 3.14e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 690 GE AM AMGERT P LALL N AP A S GR M AVG ETITNL AA SKIEK lsd I K L S A NWMAAA G H pg E DAR L Y D T V KA V G m E L C PA LG IT 769
Cdd:cd00396 1 SL AM STDGIN P PLAI N PW A G GR L AVG GAVNDI AA MGARP --- I A L L A SLSLSN G L -- E VDI L E D V V DG V A - E A C NQ LG VP 74
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 770 I PV G KD S M S MK T rwqdegvdks VTSP LSL I V TGFAP V TDI R qtltpqlrldkgetdli L ID LGRG qn R L G GSILA qvysk 849
Cdd:cd00396 75 I VG G HT S V S PG T ---------- MGHK LSL A V FAIGV V EKD R ----------------- V ID SSGA -- R P G DVLIL ----- 120
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 850 L G QQV pdvddaedlkaffav IQG L N A D G HLL A Y HD RS DGGLL A T VL E M A F A GHC G LDLY L D A LAD -------- NRDGLA A 921
Cdd:cd00396 121 T G VDA --------------- VLE L V A A G DVH A M HD IT DGGLL G T LP E L A Q A SGV G AEID L E A IPL devvrwlc VEHIEE A 185
250 260 270
....*....|....*....|....*....|....*....
gi 512733235 922 V LFN EEL G AV I Q V RQDATPE VL A qf SAA G L G DCV AVIG Q 960
Cdd:cd00396 186 L LFN SSG G LL I A V PAEEADA VL L -- LLN G N G IDA AVIG R 222
PRK14090
PRK14090 phosphoribosylformylglycinamidine synthase subunit PurL;
195-607
2.30e-22
phosphoribosylformylglycinamidine synthase subunit PurL;
Pssm-ID: 184499 [Multi-domain]
Cd Length: 601
Bit Score: 103.40
E-value: 2.30e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 195 LGR N P HD VEL MM F AQAN SEHC rhkifnaswdid G QAQE K slf GM I KNTYEMHR EG vlsaykd NA S V I egstagrffpd PV 274
Cdd:PRK14090 11 LGR E P TF VEL QA F SVMW SEHC ------------ G YSHT K --- KY I RRLPKTGF EG ------- NA G V V ----------- NL 57
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 275 TRQ Y gatqepv H I LM K V E T HNHP T AI A P FP GA S TG S GG E IRD EG A T G rg A K P K A GLTGFTV S nlqipgfeqpwekpygkp 354
Cdd:PRK14090 58 DDY Y ------- S I AF K I E S HNHP S AI E P YN GA A TG V GG I IRD VL A M G -- A R P T A IFDSLHM S ------------------ 110
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 355 e RI V tpl D IM IEG P lgg A AFN N EF G R P ALT G YF R tfeqa I DTPHG eevrgy H K P IMLAGGM G NI R AEH - V QKGEISI G AK 433
Cdd:PRK14090 111 - RI I --- D GI IEG I --- A DYG N SI G V P TVG G EL R ----- I SSLYA ------ H N P LVNVLAA G VV R NDM l V DSKASRP G QV 172
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 434 LIVL GG PAMLI G LG G GA - AS SMA TG SSSAD L dfa S V Q RDN P EM E RRCQ E VIDRCWQQ G A dnp IKFIH D V GAGG ISN A LP E 512
Cdd:PRK14090 173 IVIF GG ATGRD G IH G AS f AS EDL TG EKATK L --- S I Q VGD P FA E KMLI E AFLEMVEE G L --- VEGAQ D L GAGG VLS A TS E 246
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 513 L IND GG R G GRFE L RA VP ND EP G M S P L EI WCN ESQER YVLSVDAADFE R FKA I CERERCPFAV V G E A I AE P HLT V nd SHFG 592
Cdd:PRK14090 247 L VAK GG L G AIVH L DR VP LR EP D M E P W EI LIS ESQER MAVVTSPEKAS R ILE I AKKHLLFGDI V A E V I DD P IYR V -- MYRD 324
410
....*....|....*
gi 512733235 593 NKAVDM P LEV L LGK P 607
Cdd:PRK14090 325 DLVMEV P VQL L ANA P 339
AIRS_C
pfam02769 AIR synthase related protein, C-terminal domain; This family includes Hydrogen expression ...
838-969
6.90e-10
AIR synthase related protein, C-terminal domain; This family includes Hydrogen expression/formation protein HypE, AIR synthases EC:6.3.3.1, FGAM synthase EC:6.3.5.3 and selenide, water dikinase EC:2.7.9.3. The function of the C-terminal domain of AIR synthase is unclear, but the cleft formed between N and C domains is postulated as a sulphate binding site.
Pssm-ID: 460684 [Multi-domain]
Cd Length: 152
Bit Score: 58.90
E-value: 6.90e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 838 L G G SI L AQVYSK L --- G QQVPDVD D AEDLKAFFA V IQG L N A D G H L L - A Y HD RSD GGL LATVL EMA F A GHC G LDLY LD ALA 913
Cdd:pfam02769 14 L H G AG L SLSRKG L eds G LAAVQLG D PLLEPTLIY V KLL L A A L G G L V k A M HD ITG GGL AGALA EMA P A SGV G AEID LD KVP 93
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 914 DNRDGL ---- AAVLF N EEL G A V IQVRQD A t PE VLA QFSAA GL gd CV AVIG QPVN G ADVAI 969
Cdd:pfam02769 94 IFEELM lple MLLSE N QGR G L V VVAPEE A - EA VLA ILEKE GL -- EA AVIG EVTA G GRLTV 150
PurL_repeat2
cd02204 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. ...
431-577
5.11e-05
PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100035 [Multi-domain]
Cd Length: 264
Bit Score: 46.37
E-value: 5.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 431 G AK L IVL G GPAMLI G LGGG A ASSMAT G SSSAD ldfasvq RDNP E M E RRCQEVIDRCWQQ G A dnp IKFI HDV GA GG ISN AL 510
Cdd:cd02204 135 G DL L YLI G ETKDEL G GSEY A LAYHGL G GGAPP ------- LVDL E R E KALFDAVQELIKE G L --- VLSA HDV SD GG LAV AL 204
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 512733235 511 P E LIND GG R G GRFE L RAVPN depgms PL E IWCN ES QE R YVLS V DAADF E R F K A ic E RERC P FA V V G E 577
Cdd:cd02204 205 A E MAFA GG L G AEVD L SKDDA ------ ED E LLFS ES LG R VLVE V KPENE E V F E A -- E EAGV P AT V I G T 263
GATase1
cd01653 Type 1 glutamine amidotransferase (GATase1)-like domain; Type 1 glutamine amidotransferase ...
1045-1163
3.60e-04
Type 1 glutamine amidotransferase (GATase1)-like domain; Type 1 glutamine amidotransferase (GATase1)-like domain. This group includes proteins similar to Class I glutamine amidotransferases, the intracellular PH1704 from Pyrococcus horikoshii, the C-terminal of the large catalase: Escherichia coli HP-II, Sinorhizobium meliloti Rm1021 ThuA. and, the A4 beta-galactosidase middle domain. The majority of proteins in this group have a reactive Cys found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow. For Class I glutamine amidotransferases proteins which transfer ammonia from the amide side chain of glutamine to an acceptor substrate, this Cys forms a Cys-His-Glu catalytic triad in the active site. Glutamine amidotransferases activity can be found in a range of biosynthetic enzymes included in this cd: glutamine amidotransferase, formylglycinamide ribonucleotide, GMP synthetase, anthranilate synthase component II, glutamine-dependent carbamoyl phosphate synthase, cytidine triphosphate synthetase, gamma-glutamyl hydrolase, imidazole glycerol phosphate synthase and, cobyric acid synthase. For Pyrococcus horikoshii PH1704, the Cys of the nucleophile elbow together with a different His and, a Glu from an adjacent monomer form a catalytic triad different from the typical GATase1 triad. The E. coli HP-II C-terminal domain, S. meliloti Rm1021 ThuA and the A4 beta-galactosidase middle domain lack the catalytic triad typical GATaseI domains. GATase1-like domains can occur either as single polypeptides, as in Class I glutamine amidotransferases, or as domains in a much larger multifunctional synthase protein, such as CPSase.
Pssm-ID: 153210 [Multi-domain]
Cd Length: 115
Bit Score: 41.43
E-value: 3.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1045 VA I L REQ G VNGQ -- VEMAA A FDR AG FAAID V HMS - DILAGR V S L E D FK GL VAC GG FSYG D V L gagegwaksi LFNTRARD 1121
Cdd:cd01653 1 VA V L LFP G FEEL el ASPLD A LRE AG AEVDV V SPD g GPVESD V D L D D YD GL ILP GG PGTP D D L ---------- ARDEALLA 70
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 512733235 1122 GFQAFFERKDSF s LG V C N G C Q MM ---- SNLH E L I P G T E FWPHFVR N 1163
Cdd:cd01653 71 LLREAAAAGKPI - LG I C L G A Q LL vlgv QFHP E A I D G A E AGARLLV N 115
GAT_1
cd03128 Type 1 glutamine amidotransferase (GATase1)-like domain; Type 1 glutamine amidotransferase ...
1045-1144
2.38e-03
Type 1 glutamine amidotransferase (GATase1)-like domain; Type 1 glutamine amidotransferase (GATase1)-like domain. This group contains proteins similar to Class I glutamine amidotransferases, the intracellular PH1704 from Pyrococcus horikoshii, the C-terminal of the large catalase: Escherichia coli HP-II, Sinorhizobium meliloti Rm1021 ThuA, the A4 beta-galactosidase middle domain and peptidase E. The majority of proteins in this group have a reactive Cys found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow. For Class I glutamine amidotransferases proteins which transfer ammonia from the amide side chain of glutamine to an acceptor substrate, this Cys forms a Cys-His-Glu catalytic triad in the active site. Glutamine amidotransferases activity can be found in a range of biosynthetic enzymes included in this cd: glutamine amidotransferase, formylglycinamide ribonucleotide, GMP synthetase, anthranilate synthase component II, glutamine-dependent carbamoyl phosphate synthase (CPSase), cytidine triphosphate synthetase, gamma-glutamyl hydrolase, imidazole glycerol phosphate synthase and, cobyric acid synthase. For Pyrococcus horikoshii PH1704, the Cys of the nucleophile elbow together with a different His and, a Glu from an adjacent monomer form a catalytic triad different from the typical GATase1 triad. Peptidase E is believed to be a serine peptidase having a Ser-His-Glu catalytic triad which differs from the Cys-His-Glu catalytic triad of typical GATase1 domains, by having a Ser in place of the reactive Cys at the nucleophile elbow. The E. coli HP-II C-terminal domain, S. meliloti Rm1021 ThuA and the A4 beta-galactosidase middle domain lack the catalytic triad typical GATaseI domains. GATase1-like domains can occur either as single polypeptides, as in Class I glutamine amidotransferases, or as domains in a much larger multifunctional synthase protein, such as CPSase. Peptidase E has a circular permutation in the common core of a typical GTAse1 domain.
Pssm-ID: 153222 [Multi-domain]
Cd Length: 92
Bit Score: 38.72
E-value: 2.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 1045 VA I L REQ G VNGQ -- VEMAA A FDR AG FAAID V HMS - DILAGR V S L E D FK GL VAC GG FSYG D V L gagegwaksi LFNTRARD 1121
Cdd:cd03128 1 VA V L LFG G SEEL el ASPLD A LRE AG AEVDV V SPD g GPVESD V D L D D YD GL ILP GG PGTP D D L ---------- AWDEALLA 70
90 100
....*....|....*....|...
gi 512733235 1122 GFQAFFERKDSF s LG V C N G C Q MM 1144
Cdd:cd03128 71 LLREAAAAGKPV - LG I C L G A Q LL 92
PHA03366
PHA03366 FGAM-synthase; Provisional
498-633
7.17e-03
FGAM-synthase; Provisional
Pssm-ID: 223058 [Multi-domain]
Cd Length: 1304
Bit Score: 40.78
E-value: 7.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512733235 498 I HDV GA GG ISNA L P E LIND GGRG GRFE lra VP ND E P gms PL EIWCN E SQE r Y V LS V DAADFERFKAICERERCPFAVV G E 577
Cdd:PHA03366 872 G HDV SD GG LIAC L A E MALA GGRG VTIT --- VP AG E D --- PL QFLFS E TPG - V V IE V PPSHLSAVLTRLRSRNIICYPI G T 944
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 512733235 578 AI --- AEPHLT V nd SH F G NKAVDMP L EV L LGK pp RMHR S VSREAE L ID D FAAAELDVE D 633
Cdd:PHA03366 945 VG psg PSNTFS V -- SH N G TVLFRES L SS L RST -- WRSF S DEQFEL L RP D LTEESMYRK D 999
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
