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Conserved domains on  [gi|507090896|ref|WP_016161609|]
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MULTISPECIES: sensor histidine kinase [Klebsiella]

Protein Classification

sensor histidine kinase( domain architecture ID 11461692)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to an external signal

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0005524|GO:0004673|GO:0007165|GO:0000155
PubMed:  10637609|10339418
SCOP:  4001957

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
297-551 7.77e-70

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


:

Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 228.60  E-value: 7.77e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896 297 IHSLMVIPLWEKGVVTGTLKIYYCHAHRITSTLQEMAIGLSQIISTQLEVSRAEQLREMANKAELRALQSKINPHFLFNA 376
Cdd:COG3275   97 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLILILLALLLSLQEEELELEELEKELLEAELKALKAQINPHFLFNT 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896 377 LNAISSSIRLNPDTARQLIFNLSRYLRYNIELKDDEQIDIKRELYQIKDYIAIEQARFGDKLTVIYDIDDDV-SCVIPSL 455
Cdd:COG3275  177 LNSIYSLIREDPEKARELLLKLSDLLRYSLYESDKELVPLEEELEFLENYLELEKLRFGDRLQVEIDIDEELlDLLIPPL 256

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896 456 LIQPLVENAIVHGIQPCKGKGVVTIGINECGNRVRISVRDTGNGIDPavvarveADEMPGNKIGLLNVHHRVKLLYGE-- 533
Cdd:COG3275  257 LLQPLVENAIKHGISSKEGGGTISISIEVEGDRLVIEVENNGVGIQP-------KKKKKGSGIGLKNVRERLELLYGDky 329

                        250
                 ....*....|....*....
gi 507090896 534 GLHIRTLTP-GTEIAFYVP 551
Cdd:COG3275  330 SLEIESTDGgGTKVTLKIP 348
5TM-5TMR_LYT pfam07694
5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors ...
 29-194 2.48e-42

5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors of the LytS-YhcK type).


:

Pssm-ID: 429599  Cd Length: 170  Bit Score: 149.64  E-value: 2.48e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896   29 RLFRELLHKSAHTPKELLAVTAIFSLFALFSTWSGVPVE-GSLVNVRIIAVMSGGILFGPWVGAIVGVIAGVHRYLidID 107
Cdd:pfam07694   2 PLFRRLLSKRRLRLKDKVLLGLIFGLFSILGTYTGIEIEpGAIANTRAVGIVLAGLLGGPIVGLIAGLIAGLHRYF--LG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896  108 GVTAVPCFITSIVAGLLSGLINRKVARDQR---WKIGILAGMVCETLTMILVVVWAPSLSLGLDIVSKIGIPMIL-GSVC 183
Cdd:pfam07694  80 GFTALACGISTILAGLIAGLLHRRLKRRRRlisPLLAFLIGLIAEILQMLLILLLALPFDLALALVKTIALPMILvNSLG 159

                         170
                  ....*....|.
gi 507090896  184 IGFIVLLVQSV 194
Cdd:pfam07694 160 TAIFLSILRDR 170
GAF_2 pfam13185
GAF domain; The GAF domain is named after some of the proteins it is found in, including ...
 228-341 2.09e-03

GAF domain; The GAF domain is named after some of the proteins it is found in, including cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. It is also found in guanylyl cyclases and phytochromes. The structure of a GAF domain shows that the domain shares a similar fold with the PAS domain. This domain can bind O2, CO and NO (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


:

Pssm-ID: 433019 [Multi-domain]  Cd Length: 137  Bit Score: 38.60  E-value: 2.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896  228 LRQVCEIIRRdITADAVAI----TNTEHVLAYVGVGEANYQHHDDVISPT-TRQAIRYGKIIIKNNDEAHR--------T 294
Cdd:pfam13185   8 LDAVLEAAVE-LGASAVGFillvDDDGRLAAWGGAADELSAALDDPPGEGlVGEALRTGRPVIVNDLAADPakkglpagH 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 507090896  295 PEIHSLMVIPLWEKGVVTGTLKIYYCHAHRITSTLQEMAIGLSQIIS 341
Cdd:pfam13185  87 AGLRSFLSVPLVSGGRVVGVLALGSNRPGAFDEEDLELLELLAEQAA 133
 
Name Accession Description Interval E-value
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
297-551 7.77e-70

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 228.60  E-value: 7.77e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896 297 IHSLMVIPLWEKGVVTGTLKIYYCHAHRITSTLQEMAIGLSQIISTQLEVSRAEQLREMANKAELRALQSKINPHFLFNA 376
Cdd:COG3275   97 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLILILLALLLSLQEEELELEELEKELLEAELKALKAQINPHFLFNT 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896 377 LNAISSSIRLNPDTARQLIFNLSRYLRYNIELKDDEQIDIKRELYQIKDYIAIEQARFGDKLTVIYDIDDDV-SCVIPSL 455
Cdd:COG3275  177 LNSIYSLIREDPEKARELLLKLSDLLRYSLYESDKELVPLEEELEFLENYLELEKLRFGDRLQVEIDIDEELlDLLIPPL 256

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896 456 LIQPLVENAIVHGIQPCKGKGVVTIGINECGNRVRISVRDTGNGIDPavvarveADEMPGNKIGLLNVHHRVKLLYGE-- 533
Cdd:COG3275  257 LLQPLVENAIKHGISSKEGGGTISISIEVEGDRLVIEVENNGVGIQP-------KKKKKGSGIGLKNVRERLELLYGDky 329

                        250
                 ....*....|....*....
gi 507090896 534 GLHIRTLTP-GTEIAFYVP 551
Cdd:COG3275  330 SLEIESTDGgGTKVTLKIP 348
HATPase_YpdA-like cd16955
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 452-551 6.34e-43

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340431 [Multi-domain]  Cd Length: 102  Bit Score: 148.76  E-value: 6.34e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896 452 IPSLLIQPLVENAIVHGIQPCKGKGVVTIGINEC-GNRVRISVRDTGNGIDPAVVARVEADEMPGNKIGLLNVHHRVKLL 530
Cdd:cd16955    1 IPKLMIQPLVENAIVHGIQEKKGKGVVKISVKKQlKNRLHIAVEDNGIGISPKVIERVEQDEMPGNKIGLLNVHQRLKLG 80

                         90       100
                 ....*....|....*....|..
gi 507090896 531 YGEGLHIRTLT-PGTEIAFYVP 551
Cdd:cd16955   81 YGEGLHIRSRPdPGTLIAFYIP 102
5TM-5TMR_LYT pfam07694
5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors ...
 29-194 2.48e-42

5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors of the LytS-YhcK type).


Pssm-ID: 429599  Cd Length: 170  Bit Score: 149.64  E-value: 2.48e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896   29 RLFRELLHKSAHTPKELLAVTAIFSLFALFSTWSGVPVE-GSLVNVRIIAVMSGGILFGPWVGAIVGVIAGVHRYLidID 107
Cdd:pfam07694   2 PLFRRLLSKRRLRLKDKVLLGLIFGLFSILGTYTGIEIEpGAIANTRAVGIVLAGLLGGPIVGLIAGLIAGLHRYF--LG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896  108 GVTAVPCFITSIVAGLLSGLINRKVARDQR---WKIGILAGMVCETLTMILVVVWAPSLSLGLDIVSKIGIPMIL-GSVC 183
Cdd:pfam07694  80 GFTALACGISTILAGLIAGLLHRRLKRRRRlisPLLAFLIGLIAEILQMLLILLLALPFDLALALVKTIALPMILvNSLG 159

                         170
                  ....*....|.
gi 507090896  184 IGFIVLLVQSV 194
Cdd:pfam07694 160 TAIFLSILRDR 170
His_kinase pfam06580
Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. ...
 359-438 6.57e-31

Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.


Pssm-ID: 461952 [Multi-domain]  Cd Length: 79  Bit Score: 114.85  E-value: 6.57e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896  359 AELRALQSKINPHFLFNALNAISSSIRLNPDTARQLIFNLSRYLRYNIElKDDEQIDIKRELYQIKDYIAIEQARFGDKL 438
Cdd:pfam06580   1 AELKALQAQINPHFLFNTLNSISSLAIEDPEEAAEMILKLSDLLRYSLY-EGEELVTLEEELEFLENYLEIQKIRFGDRL 79
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 453-551 3.23e-11

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 60.36  E-value: 3.23e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896   453 PSLLIQpLVENAIVHGIQPCKGKGVVTIGINECGNRVRISVRDTGNGIDPAVVARV---------EADEMPGNKIGLLNV 523
Cdd:smart00387   3 PDRLRQ-VLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIfepffrtdkRSRKIGGTGLGLSIV 81

                           90       100
                   ....*....|....*....|....*...
gi 507090896   524 HHRVKLLYGEGLHIRTLTPGTEIAFYVP 551
Cdd:smart00387  82 KKLVELHGGEISVESEPGGGTTFTITLP 109
ECF-S COG4720
ECF-type riboflavin transporter, membrane (S) component [Coenzyme transport and metabolism];
46-191 1.14e-05

ECF-type riboflavin transporter, membrane (S) component [Coenzyme transport and metabolism];


Pssm-ID: 443755 [Multi-domain]  Cd Length: 170  Bit Score: 46.00  E-value: 1.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896  46 LAVTAIFS-LFALFSTWSGVPV--EGSLVNVRIIAVMSGGILFGPWVGAIVGVIAGVhryLIDI---DGVTAVPCFITSI 119
Cdd:COG4720    8 LVLIALFAaLVFVLTMFIKIPIpiTNGYIHLGDAFIYLAALLFGPKAGALAGGIGSA---LADLlsgYPIWAPWTFIIKG 84

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 507090896 120 VAGLLSGLINRKVARDQRWKigILAGMVCETLTMILVVVWAPSLSLGLDIVSKIGIPMILGSVCIGFIVLLV 191
Cdd:COG4720   85 LEGLIVGLIAKKLKKKSFKK--IILANILGGLVMVIGYYLAAPILYGGFAAALQSIPGNLLQAVVGAIIALI 154
GAF_2 pfam13185
GAF domain; The GAF domain is named after some of the proteins it is found in, including ...
 228-341 2.09e-03

GAF domain; The GAF domain is named after some of the proteins it is found in, including cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. It is also found in guanylyl cyclases and phytochromes. The structure of a GAF domain shows that the domain shares a similar fold with the PAS domain. This domain can bind O2, CO and NO (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 433019 [Multi-domain]  Cd Length: 137  Bit Score: 38.60  E-value: 2.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896  228 LRQVCEIIRRdITADAVAI----TNTEHVLAYVGVGEANYQHHDDVISPT-TRQAIRYGKIIIKNNDEAHR--------T 294
Cdd:pfam13185   8 LDAVLEAAVE-LGASAVGFillvDDDGRLAAWGGAADELSAALDDPPGEGlVGEALRTGRPVIVNDLAADPakkglpagH 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 507090896  295 PEIHSLMVIPLWEKGVVTGTLKIYYCHAHRITSTLQEMAIGLSQIIS 341
Cdd:pfam13185  87 AGLRSFLSVPLVSGGRVVGVLALGSNRPGAFDEEDLELLELLAEQAA 133
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
454-524 2.60e-03

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 40.82  E-value: 2.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896 454 SLLIQPLVENAIVHGIQPCKGKGVVTI---------------GINECGNRVRISVRDTGNGIDPAVVARV-------EAD 511
Cdd:PRK13837 558 PAELQQVLMNLCSNAAQAMDGAGRVDIslsraklrapkvlshGVLPPGRYVLLRVSDTGAGIDEAVLPHIfepffttRAG 637

                         90
                 ....*....|...
gi 507090896 512 empGNKIGLLNVH 524
Cdd:PRK13837 638 ---GTGLGLATVH 647
spIIAB TIGR01925
anti-sigma F factor; This model describes the SpoIIAB anti-sigma F factor. Sigma F regulates ...
 461-507 8.41e-03

anti-sigma F factor; This model describes the SpoIIAB anti-sigma F factor. Sigma F regulates spore development in B subtilis. SpoIIAB binds to sigma F, preventing formation of the transcription complex at the promoter. SpoIIAA (anti-anti-sigma F factor) binds to SpoIIAB to inhibit association with sigma F, however SpoIIAB can phosphorylate SpoIIAA, causing disassociation of the SpoIIAA/B complex. The SpoIIE phosphatase dephosphorylates SpoIIAA. [Regulatory functions, Protein interactions, Cellular processes, Sporulation and germination]


Pssm-ID: 130980 [Multi-domain]  Cd Length: 137  Bit Score: 36.82  E-value: 8.41e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 507090896  461 VENAIVHGIQpCKGKGVVTIGINECGNRVRISVRDTGNGIDPAVVAR 507
Cdd:TIGR01925  48 VTNAIIHGYE-ENCEGVVYISATIEDHEVYITVRDEGIGIENLEEAR 93
 
Name Accession Description Interval E-value
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
297-551 7.77e-70

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 228.60  E-value: 7.77e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896 297 IHSLMVIPLWEKGVVTGTLKIYYCHAHRITSTLQEMAIGLSQIISTQLEVSRAEQLREMANKAELRALQSKINPHFLFNA 376
Cdd:COG3275   97 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLILILLALLLSLQEEELELEELEKELLEAELKALKAQINPHFLFNT 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896 377 LNAISSSIRLNPDTARQLIFNLSRYLRYNIELKDDEQIDIKRELYQIKDYIAIEQARFGDKLTVIYDIDDDV-SCVIPSL 455
Cdd:COG3275  177 LNSIYSLIREDPEKARELLLKLSDLLRYSLYESDKELVPLEEELEFLENYLELEKLRFGDRLQVEIDIDEELlDLLIPPL 256

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896 456 LIQPLVENAIVHGIQPCKGKGVVTIGINECGNRVRISVRDTGNGIDPavvarveADEMPGNKIGLLNVHHRVKLLYGE-- 533
Cdd:COG3275  257 LLQPLVENAIKHGISSKEGGGTISISIEVEGDRLVIEVENNGVGIQP-------KKKKKGSGIGLKNVRERLELLYGDky 329

                        250
                 ....*....|....*....
gi 507090896 534 GLHIRTLTP-GTEIAFYVP 551
Cdd:COG3275  330 SLEIESTDGgGTKVTLKIP 348
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
325-551 1.61e-57

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 199.09  E-value: 1.61e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896 325 ITSTLQEMaigLSQIISTQLEVSRAEQLRemaNKAELRALQSKINPHFLFNALNAISSSIRLN-PDTARQLIFNLSRYLR 403
Cdd:COG2972  214 LARSFNEM---VERIKELIEEVYELELEK---KEAELKALQAQINPHFLFNTLNSIRWLAELEdPEEAEEMLEALSKLLR 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896 404 YNIElKDDEQIDIKRELYQIKDYIAIEQARFGDKLTVIYDIDDDV-SCVIPSLLIQPLVENAIVHGIQPCKGKGVVTIGI 482
Cdd:COG2972  288 YSLS-KGDELVTLEEELELIKSYLEIQKLRFGDRLEVEIEIDEELlDLLIPKLILQPLVENAIEHGIEPKEGGGTIRISI 366

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 507090896 483 NECGNRVRISVRDTGNGIDPAVVARVEADEMP---GNKIGLLNVHHRVKLLYGE--GLHIR-TLTPGTEIAFYVP 551
Cdd:COG2972  367 RKEGDRLVITVEDNGVGMPEEKLEKLLEELSSkgeGRGIGLRNVRERLKLYYGEeyGLEIEsEPGEGTTVTIRIP 441
HATPase_YpdA-like cd16955
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 452-551 6.34e-43

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340431 [Multi-domain]  Cd Length: 102  Bit Score: 148.76  E-value: 6.34e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896 452 IPSLLIQPLVENAIVHGIQPCKGKGVVTIGINEC-GNRVRISVRDTGNGIDPAVVARVEADEMPGNKIGLLNVHHRVKLL 530
Cdd:cd16955    1 IPKLMIQPLVENAIVHGIQEKKGKGVVKISVKKQlKNRLHIAVEDNGIGISPKVIERVEQDEMPGNKIGLLNVHQRLKLG 80

                         90       100
                 ....*....|....*....|..
gi 507090896 531 YGEGLHIRTLT-PGTEIAFYVP 551
Cdd:cd16955   81 YGEGLHIRSRPdPGTLIAFYIP 102
5TM-5TMR_LYT pfam07694
5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors ...
 29-194 2.48e-42

5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors of the LytS-YhcK type).


Pssm-ID: 429599  Cd Length: 170  Bit Score: 149.64  E-value: 2.48e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896   29 RLFRELLHKSAHTPKELLAVTAIFSLFALFSTWSGVPVE-GSLVNVRIIAVMSGGILFGPWVGAIVGVIAGVHRYLidID 107
Cdd:pfam07694   2 PLFRRLLSKRRLRLKDKVLLGLIFGLFSILGTYTGIEIEpGAIANTRAVGIVLAGLLGGPIVGLIAGLIAGLHRYF--LG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896  108 GVTAVPCFITSIVAGLLSGLINRKVARDQR---WKIGILAGMVCETLTMILVVVWAPSLSLGLDIVSKIGIPMIL-GSVC 183
Cdd:pfam07694  80 GFTALACGISTILAGLIAGLLHRRLKRRRRlisPLLAFLIGLIAEILQMLLILLLALPFDLALALVKTIALPMILvNSLG 159

                         170
                  ....*....|.
gi 507090896  184 IGFIVLLVQSV 194
Cdd:pfam07694 160 TAIFLSILRDR 170
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 452-551 2.02e-40

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 141.81  E-value: 2.02e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896 452 IPSLLIQPLVENAIVHGIQPCKGKGVVTIGINECGNRVRISVRDTGNGIDPAVVARVEADEMPGNKIGLLNVHHRVKLLY 531
Cdd:cd16924    1 IPPFTLQPLVENAIQHGLSPLTDKGVVTISALKEDNHVMIEVEDNGRGIDPKVLNILGKKPKEGNGIGLYNVHQRLILLF 80

                         90       100
                 ....*....|....*....|...
gi 507090896 532 GEGLHIR---TLTPGTEIAFYVP 551
Cdd:cd16924   81 GEDYGIHiasEPDKGTRITFTIP 103
His_kinase pfam06580
Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. ...
 359-438 6.57e-31

Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.


Pssm-ID: 461952 [Multi-domain]  Cd Length: 79  Bit Score: 114.85  E-value: 6.57e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896  359 AELRALQSKINPHFLFNALNAISSSIRLNPDTARQLIFNLSRYLRYNIElKDDEQIDIKRELYQIKDYIAIEQARFGDKL 438
Cdd:pfam06580   1 AELKALQAQINPHFLFNTLNSISSLAIEDPEEAAEMILKLSDLLRYSLY-EGEELVTLEEELEFLENYLEIQKIRFGDRL 79
HATPase_YehU-like cd16956
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 452-551 1.87e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.


Pssm-ID: 340432 [Multi-domain]  Cd Length: 101  Bit Score: 66.31  E-value: 1.87e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896 452 IPSLLIQPLVENAIVHGIQPCKGKGVVTIGINECGNRVRISVRDTGNGIDPAVVARVEADEMPGnkIGLLNVHHRVKLLY 531
Cdd:cd16956    1 LPFLTLQPIVENAVKHGLSGLLDGGRVEITARLDGQHLLLEVEDNGGGMDPDTLARILIRSSNG--LGLNLVDKRLRQAF 78

                         90       100
                 ....*....|....*....|...
gi 507090896 532 GE--GLHIRT-LTPGTEIAFYVP 551
Cdd:cd16956   79 GNdyGLDIECaPGEGTRITIRLP 101
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 453-551 3.23e-11

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 60.36  E-value: 3.23e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896   453 PSLLIQpLVENAIVHGIQPCKGKGVVTIGINECGNRVRISVRDTGNGIDPAVVARV---------EADEMPGNKIGLLNV 523
Cdd:smart00387   3 PDRLRQ-VLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIfepffrtdkRSRKIGGTGLGLSIV 81

                           90       100
                   ....*....|....*....|....*...
gi 507090896   524 HHRVKLLYGEGLHIRTLTPGTEIAFYVP 551
Cdd:smart00387  82 KKLVELHGGEISVESEPGGGTTFTITLP 109
HATPase_LytS-like cd16957
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 452-551 7.45e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.


Pssm-ID: 340433 [Multi-domain]  Cd Length: 106  Bit Score: 56.28  E-value: 7.45e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896 452 IPSLLIQPLVENAIVHGIQPCKGKGVVTIGINECGNRVRISVRDTGNGIDPAVVAR-----VEADEmpGNKIGLLNVHHR 526
Cdd:cd16957    1 VPPFALQVLVENAIRHAFPKRKENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLlgkttVTSEK--GTGTALENLNRR 78

                         90       100
                 ....*....|....*....|....*...
gi 507090896 527 VKLLYGE--GLHIR-TLTPGTEIAFYVP 551
Cdd:cd16957   79 LIGLFGSeaCLHIEsEVHGGTEVWFVIP 106
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 456-551 6.56e-08

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 50.83  E-value: 6.56e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896  456 LIQPLVENAIVHgiQPCKGKGVVTIginECGNRVRISVRDTGNGIDPAVVARV-------EADEMPGNKIGLLNVHHRVK 528
Cdd:pfam02518   9 VLSNLLDNALKH--AAKAGEITVTL---SEGGELTLTVEDNGIGIPPEDLPRIfepfstaDKRGGGGTGLGLSIVRKLVE 83

                          90       100
                  ....*....|....*....|...
gi 507090896  529 LLYGEGLHIRTLTPGTEIAFYVP 551
Cdd:pfam02518  84 LLGGTITVESEPGGGTTVTLTLP 106
ECF-ribofla_trS pfam07155
ECF-type riboflavin transporter, S component; This family is the substrate-binding component ...
 46-191 1.74e-07

ECF-type riboflavin transporter, S component; This family is the substrate-binding component (S component) of the energy coupling-factor (ECF)-type riboflavin transporter. It is a transmembrane protein which binds riboflavin, and is responsible for riboflavin-uptake by cells.


Pssm-ID: 429320  Cd Length: 167  Bit Score: 51.09  E-value: 1.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896   46 LAVTAIFS-LFALFSTWSGVPVEGSLVNVRI--IAVMSGGILFGPWVGAIVGVIAGVHRYLIDIDGVTAVPCFITSIVAG 122
Cdd:pfam07155   4 VVAIAIGAaLFVVLTRFISIPTPNTKGYINLgdAFLALAAVLFGPVAGFLVGFIGHALKDLLSGYGIWWPWTLIISGLEG 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 507090896  123 LLSGLINRKVARDQRWKIGILAGMVCETLTMIL--VVVWAPSLSLGLDIVS----KIGIPMILGSVCIGFIVLLV 191
Cdd:pfam07155  84 LIVGLIAKRLGKNLKNGVFNIKGLLLFNLVMVIgyVIAWGLLAPFGDLIYSepanKVFLQSIPANIIQAVVGAII 158
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 361-508 6.85e-07

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 51.72  E-value: 6.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896 361 LRALQSKINPHFLFNALNAISSSIRlnpdTARQLIFNLSRYLRynielKDDEQ---IDIKRelyQIKDYIAIEQARFGDK 437
Cdd:COG4191  168 RRRLEDEPDPEELREALERILEGAE----RAAEIVRSLRAFSR-----RDEEErepVDLNE---LIDEALELLRPRLKAR 235

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 507090896 438 -LTVIYDIDDDVSCVI--PSLLIQ---PLVENAIvHGIQPcKGKGVVTIGINECGNRVRISVRDTGNGIDPAVVARV 508
Cdd:COG4191  236 gIEVELDLPPDLPPVLgdPGQLEQvllNLLINAI-DAMEE-GEGGRITISTRREGDYVVISVRDNGPGIPPEVLERI 310
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
395-508 8.68e-07

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 51.06  E-value: 8.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896 395 IFNLSRYLRYNIELkDDEQIDIKRELYQIKDYIAiEQARfGDKLTVIYDIDDDVSCVI--PSLLIQ---PLVENAIVHGi 469
Cdd:COG0642  164 LLDLSRLEAGKLEL-EPEPVDLAELLEEVVELFR-PLAE-EKGIELELDLPDDLPTVRgdPDRLRQvllNLLSNAIKYT- 239

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 507090896 470 qpcKGKGVVTIGINECGNRVRISVRDTGNGIDPAVVARV 508
Cdd:COG0642  240 ---PEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERI 275
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 342-533 1.99e-06

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 50.23  E-value: 1.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896 342 TQLEvSRAEQLREMANKAE-LRALQskinpHFLFNALNAISSSIRLN-PDTARQLIFNLSrylrynielkDDEQIDIKRE 419
Cdd:COG3290  174 TELE-RLEEELEGVKELAEaLRAQR-----HDFRNHLHTISGLLQLGeYDEALEYIDEIS----------EELQELIDSL 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896 420 LYQIKDYI-------AIEQARfGDKLTVIYDIDddvsCVIPSLLIQP---------LVENAIVHGIQPCKGKGVVTIGIN 483
Cdd:COG3290  238 LSRIGNPVlaalllgKAARAR-ERGIDLTIDID----SDLPDLPLSDtdlvtilgnLLDNAIEAVEKLPEEERRVELSIR 312

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 507090896 484 ECGNRVRISVRDTGNGIDPAVVARVEADEMPGNK-----IGLLNVHHRVKLLYGE 533
Cdd:COG3290  313 DDGDELVIEVEDSGPGIPEELLEKIFERGFSTKLgegrgLGLALVKQIVEKYGGT 367
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
395-508 7.82e-06

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 48.40  E-value: 7.82e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896 395 IFNLSRYLRYNIELkDDEQIDIKRELYQIKDYIaieQARFGDK-LTVIYDIDDDVSCVI--PSLLIQP---LVENAIVHG 468
Cdd:COG5002  222 LLDLSRLESGELKL-EKEPVDLAELLEEVVEEL---RPLAEEKgIELELDLPEDPLLVLgdPDRLEQVltnLLDNAIKYT 297

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 507090896 469 iqpcKGKGVVTIGINECGNRVRISVRDTGNGIDPAVVARV 508
Cdd:COG5002  298 ----PEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRI 333
ECF-S COG4720
ECF-type riboflavin transporter, membrane (S) component [Coenzyme transport and metabolism];
46-191 1.14e-05

ECF-type riboflavin transporter, membrane (S) component [Coenzyme transport and metabolism];


Pssm-ID: 443755 [Multi-domain]  Cd Length: 170  Bit Score: 46.00  E-value: 1.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896  46 LAVTAIFS-LFALFSTWSGVPV--EGSLVNVRIIAVMSGGILFGPWVGAIVGVIAGVhryLIDI---DGVTAVPCFITSI 119
Cdd:COG4720    8 LVLIALFAaLVFVLTMFIKIPIpiTNGYIHLGDAFIYLAALLFGPKAGALAGGIGSA---LADLlsgYPIWAPWTFIIKG 84

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 507090896 120 VAGLLSGLINRKVARDQRWKigILAGMVCETLTMILVVVWAPSLSLGLDIVSKIGIPMILGSVCIGFIVLLV 191
Cdd:COG4720   85 LEGLIVGLIAKKLKKKSFKK--IILANILGGLVMVIGYYLAAPILYGGFAAALQSIPGNLLQAVVGAIIALI 154
HATPase_RsbW-like cd16936
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ...
 455-515 1.91e-05

Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.


Pssm-ID: 340413 [Multi-domain]  Cd Length: 91  Bit Score: 43.41  E-value: 1.91e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 507090896 455 LLIQPLVENAIVHGiQPCKGKGVVTIGINECGNRVRISVRDTGNGIDPAVVARVEADEMPG 515
Cdd:cd16936    3 LAVSEAVTNAVRHA-YRHDGPGPVRLELDLDPDRLRVEVTDSGPGFDPLRPADPDAGLREG 62
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
460-525 2.18e-05

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 44.13  E-value: 2.18e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 507090896 460 LVENAIVHGiQPCKGKGVVTIGINECGNRVRISVRDTGNGIDPAVVARVEADEMPGNkIGLLNVHH 525
Cdd:COG2172   42 AVTNAVRHA-YGGDPDGPVEVELELDPDGLEIEVRDEGPGFDPEDLPDPYSTLAEGG-RGLFLIRR 105
ECF_trnsprt pfam12822
ECF transporter, substrate-specific component; Energy-coupling factor (ECF) transporters ...
 46-159 2.21e-05

ECF transporter, substrate-specific component; Energy-coupling factor (ECF) transporters consist of a substrate-specific component (known as the S component), and an energy-coupling module. The substrate-binding component is a small integral membrane protein which captures specific substrates and forms an active transporter in the presence of the energy-coupling AT module.


Pssm-ID: 432808  Cd Length: 157  Bit Score: 44.99  E-value: 2.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896   46 LAVTAIFS----LFALFSTWSGVPVEGSLVNvriIAVMSGGILFGPWVGAIVGVIAGVHRYLIDID-GVTAVPCFI-TSI 119
Cdd:pfam12822   3 LVIIALLSalsiVLMFTPPFPPIPLKIDLSH---IPALLGALLLGPLAGILIGLLTSLLSALTTGGgGPTGEPANFlPGI 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 507090896  120 VAGLLSGLI--NRKVARDQRWKIGILAGMVCETLTMILVVVW 159
Cdd:pfam12822  80 LIGLVAGYLykYGRNKKKKRILLALILGTILGTLVATLLNLL 121
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
376-551 2.54e-05

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 46.05  E-value: 2.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896 376 ALNAISSSIRLNPDTARQLIFNL---SRYLRYNIE--LK----DDEQIDIKRELYQIKDYI--AIEQARF---GDKLTVI 441
Cdd:COG2205   37 AAELLLDEEDLSPEERRELLEIIresAERLLRLIEdlLDlsrlESGKLSLELEPVDLAELLeeAVEELRPlaeEKGIRLE 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896 442 YDIDDDVSCVI--PSLLIQ---PLVENAIVHGiqpcKGKGVVTIGINECGNRVRISVRDTGNGIDPAVVARV-------- 508
Cdd:COG2205  117 LDLPPELPLVYadPELLEQvlaNLLDNAIKYS----PPGGTITISARREGDGVRISVSDNGPGIPEEELERIferfyrgd 192

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 507090896 509 EADEMPGNKIGLLNVHHRVKLLYGEgLHIR-TLTPGTEIAFYVP 551
Cdd:COG2205  193 NSRGEGGTGLGLAIVKRIVEAHGGT-IWVEsEPGGGTTFTVTLP 235
HATPase_EL346-LOV-HK-like cd16951
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 422-551 4.11e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.


Pssm-ID: 340427 [Multi-domain]  Cd Length: 131  Bit Score: 43.56  E-value: 4.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896 422 QIKDYIAIEQARFGDKLTVI---YDIDDDVSCVIpSLLIQPLVENAIVHGIQPcKGKGVVTIGINECGNRVRISVRDTGN 498
Cdd:cd16951    7 RIASAINAIHAVGDIRINITgdtGPVSSEVATAI-GLVVNELLQNALKHAFSD-REGGTITIRSVVDGDYLRITVIDDGV 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 507090896 499 GIDpavvarVEADEMPGNKIGLLNVHHRVKLLYGEGLHIRTLTPGTEIAFYVP 551
Cdd:cd16951   85 GLP------QDEDWPNKGSLGLQIVRSLVEGELKAFLEVQSAENGTRVNIDIP 131
GAF COG2203
GAF domain [Signal transduction mechanisms];
119-462 1.39e-04

GAF domain [Signal transduction mechanisms];


Pssm-ID: 441805 [Multi-domain]  Cd Length: 712  Bit Score: 44.80  E-value: 1.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896 119 IVAGLLSGLINRKVARDQRWKIGILAGMVCETLTMILVVVWAPSLSLGLDIVSKIGIPMILGSVCIGFIVLLVQSVEGEK 198
Cdd:COG2203  106 LRLLALLVLLLVALALAEALAARLLDLLLLGLGGRLRGVVLRGLRSAALLLSRVDTDLVGQLAALAGLILDIARLLTQRA 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896 199 EASAARQAKLA--LDIANKTLPLfrhvnSDSLRQVCEIIRRDITADAVAI------TNTEHVLAYVGVGEANYQHHDDVI 270
Cdd:COG2203  186 RLELERLALLNeiSQALRSALDL-----EELLQRILELAGELLGADRGAIllvdedGGELELVAAPGLPEEELGRLPLGE 260

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896 271 SPTtRQAIRYGKIII-----------KNNDEAHRTPEIHSLMVIPLWEKGVVTGTLKIYYCHAHRITSTLQEMAIGLSQI 339
Cdd:COG2203  261 GLA-GRALRTGEPVVvndastdprfaPSLRELLLALGIRSLLCVPLLVDGRLIGVLALYSKEPRAFTEEDLELLEALADQ 339

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896 340 ISTQLEVSRAEQLREMANKAELRALQSKINPHFLFNALNAISSSIRLNPDTARQLIFNLSRYLRYNIELKDDEQIDIKRE 419
Cdd:COG2203  340 AAIAIERARLYEALEAALAALLQELALLRLLLDLELTLLRLRQLLLELLLALLLLLSLLGAELLLLLLDAADLSGLLALE 419

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 507090896 420 LYQIKDYIAIEQARFGDKLTVIYDIDDDVSCVIPSLLIQPLVE 462
Cdd:COG2203  420 GLLLLDLLLLLLLLRRILLLRVLRRLLLGDEEGLVLLLALAEL 462
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
423-508 1.81e-04

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 44.07  E-value: 1.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896 423 IKDYIAIEQARFGDKLTVIYDIDDDVSCVI--PSLLIQpLVENAIVHGIQPCKGKGVVTI----------GINECGNRVR 490
Cdd:COG3852  210 LERVLELLRAEAPKNIRIVRDYDPSLPEVLgdPDQLIQ-VLLNLVRNAAEAMPEGGTITIrtrverqvtlGGLRPRLYVR 288

                         90
                 ....*....|....*...
gi 507090896 491 ISVRDTGNGIDPAVVARV 508
Cdd:COG3852  289 IEVIDNGPGIPEEILDRI 306
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 453-508 2.77e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 40.48  E-value: 2.77e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 507090896 453 PSLLIQPLVeNAIVHGIQPCKGKGVVTIGINECGNRVRISVRDTGNGIDPAVVARV 508
Cdd:cd16943    1 PSQLNQVLL-NLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRI 55
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
478-551 7.13e-04

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 41.53  E-value: 7.13e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 507090896 478 VTIGINECGNRVRISVRDTGNGIDPavvarveaDEMPGNKIGLLNVHHRVKLLYGEgLHIRTlTP--GTEIAFYVP 551
Cdd:COG4585  183 VTVTLEVDDGELTLTVRDDGVGFDP--------EAAPGGGLGLRGMRERAEALGGT-LTIGS-APggGTRVRATLP 248
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 456-520 7.23e-04

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 42.46  E-value: 7.23e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 507090896 456 LIQPLVENAIVHGIQpcKGKGVVTIGINECGNRVRISVRDTGNGIDPAVVARV--------EADEMPGNKIGL 520
Cdd:COG4251  398 VFQNLISNAIKYSRP--GEPPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIfeifqrlhSRDEYEGTGIGL 468
HATPase_SpoIIAB-like cd16942
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein ...
 461-507 1.13e-03

Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of SpoIIAB, an anti sigma-F factor and a serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli where, early in sporulation, the cell divides into two unequal compartments: a larger mother cell and a smaller forespore. Sigma-F transcription factor is activated in the forespore directly after the asymmetric septum forms, and its spatial and temporal activation is required for sporulation. Free sigma-F can associate with the RNA polymerase core and activate transcription of the sigma-F regulon, its regulation may comprise a partner-switching mechanism involving SpoIIAB, SpoIIAA, and sigma-F as follows: SpoIIAB can form alternative complexes with either: i) sigma-F, holding it in an inactive form and preventing its association with RNA polymerase, or ii) unphosphorylated SpoIIAA and a nucleotide, either ATP or ADP. In the presence of ATP, SpoIIAB acts as a kinase to specifically phosphorylate a serine residue of SpoIIAA; this phosphorylated form has low affinity for SpoIIAB and dissociates, making SpoIIAB available to capture sigma-F. SpoIIAA may then be dephosphorylated by a SpoIIE serine phosphatase and be free to attack the SpoIIAB sigma-F complex to induce the release of sigma-F.


Pssm-ID: 340418 [Multi-domain]  Cd Length: 135  Bit Score: 39.44  E-value: 1.13e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 507090896 461 VENAIVHGIQpCKGKGVVTIGINECGNRVRISVRDTGNGIDPAVVAR 507
Cdd:cd16942   47 VTNAIIHGYN-NDPNGIVSISVIIEDGVVHLTVRDEGVGIPDIEEAR 92
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 430-508 1.33e-03

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 41.49  E-value: 1.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896 430 EQARFGDKLTVIYDIDDDVSCVI--PSLLIQP---LVENAIvhgiQPCKGKGVVTIGINECGNRVRISVRDTGNGIDPAV 504
Cdd:COG5000  290 EPALKEKDIRLELDLDPDLPEVLadRDQLEQVlinLLKNAI----EAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEV 365


                 ....
gi 507090896 505 VARV 508
Cdd:COG5000  366 LERI 369
GAF_2 pfam13185
GAF domain; The GAF domain is named after some of the proteins it is found in, including ...
 228-341 2.09e-03

GAF domain; The GAF domain is named after some of the proteins it is found in, including cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. It is also found in guanylyl cyclases and phytochromes. The structure of a GAF domain shows that the domain shares a similar fold with the PAS domain. This domain can bind O2, CO and NO (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 433019 [Multi-domain]  Cd Length: 137  Bit Score: 38.60  E-value: 2.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896  228 LRQVCEIIRRdITADAVAI----TNTEHVLAYVGVGEANYQHHDDVISPT-TRQAIRYGKIIIKNNDEAHR--------T 294
Cdd:pfam13185   8 LDAVLEAAVE-LGASAVGFillvDDDGRLAAWGGAADELSAALDDPPGEGlVGEALRTGRPVIVNDLAADPakkglpagH 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 507090896  295 PEIHSLMVIPLWEKGVVTGTLKIYYCHAHRITSTLQEMAIGLSQIIS 341
Cdd:pfam13185  87 AGLRSFLSVPLVSGGRVVGVLALGSNRPGAFDEEDLELLELLAEQAA 133
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
454-524 2.60e-03

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 40.82  E-value: 2.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896 454 SLLIQPLVENAIVHGIQPCKGKGVVTI---------------GINECGNRVRISVRDTGNGIDPAVVARV-------EAD 511
Cdd:PRK13837 558 PAELQQVLMNLCSNAAQAMDGAGRVDIslsraklrapkvlshGVLPPGRYVLLRVSDTGAGIDEAVLPHIfepffttRAG 637

                         90
                 ....*....|...
gi 507090896 512 empGNKIGLLNVH 524
Cdd:PRK13837 638 ---GTGLGLATVH 647
HATPase_CheA-like cd16916
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ...
 460-507 3.60e-03

Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.


Pssm-ID: 340393 [Multi-domain]  Cd Length: 178  Bit Score: 38.72  E-value: 3.60e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 507090896 460 LVENAIVHGIQP-----CKGK---GVVTIGINECGNRVRISVRDTGNGIDPAVVAR 507
Cdd:cd16916   46 LLRNAVDHGIEApeerlAAGKppeGTITLRAEHQGNQVVIEVSDDGRGIDREKIRE 101
SpoIIE COG5817
Stage II sporulation protein SpoIIE/SpoIIH (serine phosphatase - sigma-F activation) [Cell ...
 4-191 4.75e-03

Stage II sporulation protein SpoIIE/SpoIIH (serine phosphatase - sigma-F activation) [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444519 [Multi-domain]  Cd Length: 803  Bit Score: 39.87  E-value: 4.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896   4 IFTMMLAVYDRAALMLICLFFLIRLRLFRELLHKSAHTPKELLAVtaIFSLFALFSTWSGVPVEG-SLVNVRII-AVMSG 81
Cdd:COG5817  147 PYDLLMALFEAILAFVLTYIFLQALPLLTEKRKRKSLTNEEIICL--LILLASVLTGLGGLTIGGlSLKNILSRlLVLLA 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507090896  82 GILFGPWVGAIVGVIAGVhryLIDIDGVTAVpcFITSI--VAGLLSGLINRKVardqrwKIGILAGMVCETLtmiLVVVW 159
Cdd:COG5817  225 AYIGGAGLGAAVGVVIGL---ILSLSNGSSP--YMIGLyaFAGLLAGLFREFG------KLGVALGFLLGNL---LLTLY 290

                        170       180       190
                 ....*....|....*....|....*....|..
gi 507090896 160 APSLSLgldivskigIPMILGSVCIGFIVLLV 191
Cdd:COG5817  291 VSGSGE---------LLLSLYEIAIASLLFLL 313
PRK10337 PRK10337
sensor protein QseC; Provisional
 454-508 4.85e-03

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 39.63  E-value: 4.85e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 507090896 454 SLLIQPLVENAIVHgiqpCKGKGVVTIGINEcgnrVRISVRDTGNGIDPAVVARV 508
Cdd:PRK10337 354 SLLVRNLLDNAIRY----SPQGSVVDVTLNA----RNFTVRDNGPGVTPEALARI 400
spIIAB TIGR01925
anti-sigma F factor; This model describes the SpoIIAB anti-sigma F factor. Sigma F regulates ...
 461-507 8.41e-03

anti-sigma F factor; This model describes the SpoIIAB anti-sigma F factor. Sigma F regulates spore development in B subtilis. SpoIIAB binds to sigma F, preventing formation of the transcription complex at the promoter. SpoIIAA (anti-anti-sigma F factor) binds to SpoIIAB to inhibit association with sigma F, however SpoIIAB can phosphorylate SpoIIAA, causing disassociation of the SpoIIAA/B complex. The SpoIIE phosphatase dephosphorylates SpoIIAA. [Regulatory functions, Protein interactions, Cellular processes, Sporulation and germination]


Pssm-ID: 130980 [Multi-domain]  Cd Length: 137  Bit Score: 36.82  E-value: 8.41e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 507090896  461 VENAIVHGIQpCKGKGVVTIGINECGNRVRISVRDTGNGIDPAVVAR 507
Cdd:TIGR01925  48 VTNAIIHGYE-ENCEGVVYISATIEDHEVYITVRDEGIGIENLEEAR 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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