NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|506403442|ref|WP_015923161|]
View 

amino acid ABC transporter permease [Cereibacter sphaeroides]

Protein Classification

amino acid ABC transporter permease( domain architecture ID 11433582)

amino acid ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter which binds and transports amino acids

Gene Ontology:  GO:0140359|GO:0042626|GO:0006865
PubMed:  25750732|24638992
TCDB:  3.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 161-369 9.42e-60

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


:

Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 192.21  E-value: 9.42e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506403442 161 WGGLPLTMLLFTGTVLIGMPVAVLLALGRRAPLPVARGVSVVFIEALRGVPLITILFVAVNVFPLFlpaGVEVNKLLRIT 240
Cdd:COG0765   16 LEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLL---GIDLSPFVAAV 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506403442 241 VGIAIFFACYQAEVIRGGLQAIPTGQYEAAASLSLSYWQTTRRIILPQALRISLPAITNHIIAAMKNTSFVIIIGLFDIL 320
Cdd:COG0765   93 IALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLVSVIGVPELT 172

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 506403442 321 TATTAVMQDPLwrkFYIEAYLFVAAVYLFFGYALSLYARQVEKWIASGR 369
Cdd:COG0765  173 RAAQQIASRTF---RPFEVYLVAALIYLVLTLPLSLLARRLERRLARGR 218
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 161-369 9.42e-60

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 192.21  E-value: 9.42e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506403442 161 WGGLPLTMLLFTGTVLIGMPVAVLLALGRRAPLPVARGVSVVFIEALRGVPLITILFVAVNVFPLFlpaGVEVNKLLRIT 240
Cdd:COG0765   16 LEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLL---GIDLSPFVAAV 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506403442 241 VGIAIFFACYQAEVIRGGLQAIPTGQYEAAASLSLSYWQTTRRIILPQALRISLPAITNHIIAAMKNTSFVIIIGLFDIL 320
Cdd:COG0765   93 IALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLVSVIGVPELT 172

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 506403442 321 TATTAVMQDPLwrkFYIEAYLFVAAVYLFFGYALSLYARQVEKWIASGR 369
Cdd:COG0765  173 RAAQQIASRTF---RPFEVYLVAALIYLVLTLPLSLLARRLERRLARGR 218
PRK15100 PRK15100
cystine ABC transporter permease;
163-314 1.38e-23

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 97.13  E-value: 1.38e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506403442 163 GLPLTMLLFTGTVLIGMPVAVLLALGRRAPLPVARGVSVVFIEALRGVPLITILFVAVNVFPLFlpaGVEVNKLLRITVG 242
Cdd:PRK15100  18 GAGYTLQLSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYVSIFRGTPLIAQLFMIYYGLPQF---GIELDPIPAAMIG 94

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 506403442 243 IAIFFACYQAEVIRGGLQAIPTGQYEAAASLSLSYWQTTRRIILPQALRISLPAITNHIIAAMKNTSFVIII 314
Cdd:PRK15100  95 LSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAATI 166
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 163-363 3.95e-22

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 92.99  E-value: 3.95e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506403442  163 GLPLTMLLFTGTVLIGMPVAVLLALGRR-APLPVARGVSVVfIEALRGVPLITILFVAVNVFPLFlpaGVEVNKLLRITV 241
Cdd:TIGR03003  16 GLKITILATALGFAIAAVLGLVFAILRRsAPTPISWPTSFV-VEFIRGTPLLVQLYFLYYVLPDI---GIRLPALVAGVL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506403442  242 GIAIFFACYQAEVIRGGLQAIPTGQYEAAASLSLSYWQTTRRIILPQALRISLPAITNHIIAAMKNTSFVIIIGLFDILT 321
Cdd:TIGR03003  92 GLGLHYATYAAEVYRAGIEAVPRGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETPVLSAITVLELMN 171

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 506403442  322 ATTAVMQDPLWrkfYIEAYLFVAAVYLFFGYALSLYARQVEK 363
Cdd:TIGR03003 172 QAKSIGNSTFR---YLEPMTLVGVFFLILSIISVFFLRRLEA 210
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 164-356 1.06e-15

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 74.62  E-value: 1.06e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506403442 164 LPLTMLLFTGTVLIGMPVAVLLALGRRAPLPVARGVSVVFIEALRGVPLITILFVAVNVFPLFLPAGVEVNKLLRITVGI 243
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPGLGLPALILA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506403442 244 AIFFACYQAEVIRGGLQAIPTGQYEAAASLSLSYWQTTRRIILPQALRISLPAITNHIIAAMKNTSFVIIIGLFDILTAT 323
Cdd:cd06261   81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                        170       180       190
                 ....*....|....*....|....*....|...
gi 506403442 324 TAVMQdplWRKFYIEAYLFVAAVYLFFGYALSL 356
Cdd:cd06261  161 TGLLL---IFAILFPGDLGVAAAVALILLLLSL 190
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 178-365 1.27e-07

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 51.15  E-value: 1.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506403442  178 GMPVAVLLALGRRAPLpvaRGVSVVFIEALRGVPLITILFVAVNVFPLFLPAGVEVNKLLRITVGIAIFFAcyqaEVIRG 257
Cdd:pfam00528   1 GIPLGIIAALRRGRRL---DRLLRPLIDLLQALPSFVLAILLVVIAILSILGHGILPAIILALLGWAGYAR----LIRRA 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506403442  258 GLQAIPTGQYEAAASLSLSYWQTTRRIILPQALRISLPAITNHIIAAMKNTSFVIIIGLFDILTATTAVMQDPLWRKFYI 337
Cdd:pfam00528  74 ALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGLLLIEAILGYDYPEIQ 153

                         170       180
                  ....*....|....*....|....*...
gi 506403442  338 EAYLFVAAVYLFFGYALSLYARQVEKWI 365
Cdd:pfam00528 154 GPVLAAALILLLLNLLVDILQRLLDPRV 181
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 161-369 9.42e-60

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 192.21  E-value: 9.42e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506403442 161 WGGLPLTMLLFTGTVLIGMPVAVLLALGRRAPLPVARGVSVVFIEALRGVPLITILFVAVNVFPLFlpaGVEVNKLLRIT 240
Cdd:COG0765   16 LEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLL---GIDLSPFVAAV 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506403442 241 VGIAIFFACYQAEVIRGGLQAIPTGQYEAAASLSLSYWQTTRRIILPQALRISLPAITNHIIAAMKNTSFVIIIGLFDIL 320
Cdd:COG0765   93 IALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLVSVIGVPELT 172

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 506403442 321 TATTAVMQDPLwrkFYIEAYLFVAAVYLFFGYALSLYARQVEKWIASGR 369
Cdd:COG0765  173 RAAQQIASRTF---RPFEVYLVAALIYLVLTLPLSLLARRLERRLARGR 218
ArtM COG4160
ABC-type arginine/histidine transport system, permease component [Amino acid transport and ...
 161-365 1.05e-31

ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443325 [Multi-domain]  Cd Length: 229  Bit Score: 119.43  E-value: 1.05e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506403442 161 WGGLPLTMLLFTGTVLIGMPVAVLLALGRRAPLPVARGVSVVFIEALRGVPLITILFVAVNVFPLFlPA--GVEVNKLLR 238
Cdd:COG4160   14 LSGLPLTLQLLALSLLLGFLLAVPLALARASGNRLLRWPARGYIYVFRGTPLLVQLFLIYYGLGQF-EWvrESWLWPLLR 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506403442 239 ITVGIAIF-----FACYQAEVIRGGLQAIPTGQYEAAASLSLSYWQTTRRIILPQALRISLPAITNHIIAAMKNTSFVII 313
Cdd:COG4160   93 DPWFCALLaltlnTAAYTAEIFRGAIRAVPKGEIEAARALGMSRWQTFRRIILPSALRRALPAYSNEVILMLKATALAST 172

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 506403442 314 IGLFDILTATTAVMQdplwrKFY--IEAYLFVAAVYLFFGYALSLYARQVEKWI 365
Cdd:COG4160  173 ITVMDLTGVARRIYS-----RTYdpFEPFLIAALIYLVITFLLTRLFRLLERRL 221
PRK15100 PRK15100
cystine ABC transporter permease;
163-314 1.38e-23

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 97.13  E-value: 1.38e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506403442 163 GLPLTMLLFTGTVLIGMPVAVLLALGRRAPLPVARGVSVVFIEALRGVPLITILFVAVNVFPLFlpaGVEVNKLLRITVG 242
Cdd:PRK15100  18 GAGYTLQLSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYVSIFRGTPLIAQLFMIYYGLPQF---GIELDPIPAAMIG 94

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 506403442 243 IAIFFACYQAEVIRGGLQAIPTGQYEAAASLSLSYWQTTRRIILPQALRISLPAITNHIIAAMKNTSFVIII 314
Cdd:PRK15100  95 LSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAATI 166
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 163-363 3.95e-22

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 92.99  E-value: 3.95e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506403442  163 GLPLTMLLFTGTVLIGMPVAVLLALGRR-APLPVARGVSVVfIEALRGVPLITILFVAVNVFPLFlpaGVEVNKLLRITV 241
Cdd:TIGR03003  16 GLKITILATALGFAIAAVLGLVFAILRRsAPTPISWPTSFV-VEFIRGTPLLVQLYFLYYVLPDI---GIRLPALVAGVL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506403442  242 GIAIFFACYQAEVIRGGLQAIPTGQYEAAASLSLSYWQTTRRIILPQALRISLPAITNHIIAAMKNTSFVIIIGLFDILT 321
Cdd:TIGR03003  92 GLGLHYATYAAEVYRAGIEAVPRGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETPVLSAITVLELMN 171

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 506403442  322 ATTAVMQDPLWrkfYIEAYLFVAAVYLFFGYALSLYARQVEK 363
Cdd:TIGR03003 172 QAKSIGNSTFR---YLEPMTLVGVFFLILSIISVFFLRRLEA 210
BatB COG4597
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 163-356 1.37e-17

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443651 [Multi-domain]  Cd Length: 397  Bit Score: 83.27  E-value: 1.37e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506403442 163 GLPLTMLLFTGTVLIGMPVAVLLALGrrAPL----PVARGVSvvfieaLRGVPLITILFVAVnvfplflpagvevnkllr 238
Cdd:COG4597  215 GQRFPVWWISLALLVGLPLLAFLLLG--APLsldyPELKGFN------FRGGLTLSPEFVAL------------------ 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506403442 239 iTVGIAIFFACYQAEVIRGGLQAIPTGQYEAAASLSLSYWQTTRRIILPQALRISLPAITNHIIAAMKNTSFVIIIGLFD 318
Cdd:COG4597  269 -LLALSLYTAAFIAEIVRAGIQAVSKGQTEAARALGLRPGQTLRLVVLPQALRVIIPPLTSQYLNLTKNSSLAVAIGYPD 347

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 506403442 319 I--LTATTAVMQDPLwrkfYIEAYLFVAAVYLFFGYALSL 356
Cdd:COG4597  348 LvsVFAGTTLNQTGQ----AIEIIAITMAVYLTISLLISL 383
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 161-363 1.43e-17

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 80.48  E-value: 1.43e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506403442 161 WGGLPLTMLLFTGTVLI-------GMPVAVLLALGRRAPLPVARGVSVVFIEALRGVPLITILFVAVNVFPLFLPaGVEV 233
Cdd:PRK09494   9 WPAIPLLLEGAKMTLWIsvlglagGLVIGLLAGFARAYGGWIANHIALVFIELIRGTPIVVQVMFIYFALPMAFN-DLRI 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506403442 234 NKLLRITVGIAIFFACYQAEVIRGGLQAIPTGQYEAAASLSLSYWQTTRRIILPQALRISLPAITNHIIAAMKNTSFVII 313
Cdd:PRK09494  88 DPFTAAVVTIMINSGAYIAEITRGAVLSIHKGFREAGLALGLSRRETLRYVIGPLALRRMLPPLGNQWIISIKDTSLFIV 167

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 506403442 314 IGLFDIltatTAVMQDPLWRKFY-IEAYLFVAAVYLFFGYALSLYARQVEK 363
Cdd:PRK09494 168 IGVAEL----TRQGQEIIAGNFRaLEIWSAVAVIYLIITLVLSFILRRLER 214
PRK11123 PRK11123
arginine ABC transporter permease ArtQ;
176-365 3.00e-17

arginine ABC transporter permease ArtQ;


Pssm-ID: 182979 [Multi-domain]  Cd Length: 238  Bit Score: 80.11  E-value: 3.00e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506403442 176 LIGMPVAVLLALGRRAPLPVARGVSVVFIEALRGVP-LITILFV-------------------AVNVFPLFLPAG-VEVN 234
Cdd:PRK11123  23 IVGLALAMLFAVWESAKWRPVAWPGTALVTLLRGLPeILVVLFIyfgssqllltlsdgftlnlGFVQIPVQMDIEnFEVS 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506403442 235 KLLRITVGIAIFFACYQAEVIRGGLQAIPTGQYEAAASLSLSYWQTTRRIILPQALRISLPAITNHIIAAMKNTSFVIII 314
Cdd:PRK11123 103 PFLCGVIALSLLYAAYASQTLRGALKAVPVGQWESGQALGLSKSAIFFRLVMPQMWRHALPGLGNQWLVLLKDTALVSLI 182

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 506403442 315 GLFDILTAT---TAVMQDPL-WrkfyieaYLFVAAVYLffgyALSLYARQVEKWI 365
Cdd:PRK11123 183 SVNDLMLQTksiATRTQEPFtW-------YIIAAAIYL----VITLISQYILKRI 226
PRK15107 PRK15107
glutamate/aspartate ABC transporter permease GltK;
161-363 2.44e-16

glutamate/aspartate ABC transporter permease GltK;


Pssm-ID: 185062 [Multi-domain]  Cd Length: 224  Bit Score: 77.18  E-value: 2.44e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506403442 161 WGGLPLTMLLFTGTVLIGMPVAVLLALGRRAPLPVARGVSVVFIEALRGVPLITILFVAVNVFPLFLPAGVEVN-----K 235
Cdd:PRK15107  17 LDGLVITLKITVTAVVIGILWGTILAVMRLSSFKPVAWFAKAYVNVFRSIPLVMVLLWFYLIVPGFLQNVLGLSpktdiR 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506403442 236 LLRITVGIAIFFACYQAEVIRGGLQAIPTGQYEAAASLSLSYWQTTRRIILPQALRISLPAITNHIIAAMKNTSFVIIIG 315
Cdd:PRK15107  97 LISAMVAFSMFEAAYYSEIIRAGIQSISRGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQGIVLFQDTSLVYVLS 176

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 506403442 316 LFDIL-TATTAVMQDPLwrkfYIEAYLFVAAVYLFFGYALSLYARQVEK 363
Cdd:PRK15107 177 LADFFrTASTIGERDGT----QVEMILFAGFVYFVISLSASLLVSYLKK 221
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 164-356 1.06e-15

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 74.62  E-value: 1.06e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506403442 164 LPLTMLLFTGTVLIGMPVAVLLALGRRAPLPVARGVSVVFIEALRGVPLITILFVAVNVFPLFLPAGVEVNKLLRITVGI 243
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPGLGLPALILA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506403442 244 AIFFACYQAEVIRGGLQAIPTGQYEAAASLSLSYWQTTRRIILPQALRISLPAITNHIIAAMKNTSFVIIIGLFDILTAT 323
Cdd:cd06261   81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                        170       180       190
                 ....*....|....*....|....*....|...
gi 506403442 324 TAVMQdplWRKFYIEAYLFVAAVYLFFGYALSL 356
Cdd:cd06261  161 TGLLL---IFAILFPGDLGVAAAVALILLLLSL 190
PRK15069 PRK15069
histidine ABC transporter permease HisM;
163-366 6.87e-14

histidine ABC transporter permease HisM;


Pssm-ID: 185029 [Multi-domain]  Cd Length: 234  Bit Score: 70.46  E-value: 6.87e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506403442 163 GLPLTMLLFTGTVLIGMPVAVLLALGRRAPLPVARGVSVVFIEALRGVPL-ITILFVAVNVFPLFLPAGVEV-NKLLRIT 240
Cdd:PRK15069  22 GLAITLWLLVASVVIGFVLAVPLAIARVSSNKWIRFPVWLYTYVFRGTPLyVQLLVFYTGMYSLEIVRGTDLlDAFFRSG 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506403442 241 VGIAIF-FA----CYQAEVIRGGLQAIPTGQYEAAASLSLSYWQTTRRIILPQALRISLPAITNHIIAAMKNTSFVIIIG 315
Cdd:PRK15069 102 LNCTILaFTlntcAYTTEIFAGAIRSVPHGEIEAARAYGMSTFKLYRRIILPSALRRALPAYSNEVILMLHATTLAFTAT 181

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 506403442 316 LFDILTATTAVmQDPLWRKFYieAYLFVAAVYLFFGYAL-SLYARQVEKWIA 366
Cdd:PRK15069 182 VPDILKIARDI-NSATYQPFQ--AFGIAAVLYLIISFVLiSLFRRAERRWLA 230
PRK15135 PRK15135
histidine ABC transporter permease HisQ;
181-350 2.89e-10

histidine ABC transporter permease HisQ;


Pssm-ID: 185089 [Multi-domain]  Cd Length: 228  Bit Score: 59.81  E-value: 2.89e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506403442 181 VAVLLAL-GRRAPLPVARGVSVVF---IEALRGVP---LITILF----VAVNVFPLFLPAG-VEVNKLLRITVGIAIFFA 248
Cdd:PRK15135  26 LAVIIGLiGAGGKLSQNRLLGLIFegyTTLIRGVPdlvLMLLIFyglqIALNSVTEALGVGqIDIDPMVAGIITLGFIYG 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506403442 249 CYQAEVIRGGLQAIPTGQYEAAASLSLSYWQTTRRIILPQALRISLPAITNHIIAAMKNTSFVIIIGLFDILTATTAVMQ 328
Cdd:PRK15135 106 AYFTETFRGAFMAVPKGHIEAATAFGFTRGQVFRRIMFPAMMRYALPGIGNNWQVILKATALVSLLGLEDVVKATQLAGK 185

                        170       180
                 ....*....|....*....|..
gi 506403442 329 DPlWRKFYIEayLFVAAVYLFF 350
Cdd:PRK15135 186 ST-WEPFYFA--IVCGVIYLVF 204
HEQRo_perm_3TM TIGR01726
amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This ...
 161-257 4.67e-10

amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This model represents one of several classes of multiple membrane spanning regions found immediately N-terminal to the domain described by pfam00528, binding-protein-dependent transport systems inner membrane component. The region covered by this model generally is predicted to contain three transmembrane helices. Substrate specificities attributed to members of this family include histidine, arginine, glutamine, glutamate, and (in Agrobacterium) the opines octopine and nopaline. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130787 [Multi-domain]  Cd Length: 99  Bit Score: 56.00  E-value: 4.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506403442  161 WGGLPLTMLLFTGTVLIGMPVAVLLALGRRAPLPVARGVSVVFIEALRGVPLITILFVAVNVFPLFlpaGVEVNKLLRIT 240
Cdd:TIGR01726   6 LKGLLLTLLLSVLSILLGLVLGLLLALLRLSGNRPLRWIATVYVELFRGTPLLVQLFFIYFGLPLI---GIRLSPLTAAV 82

                          90
                  ....*....|....*..
gi 506403442  241 VGIAIFFACYQAEVIRG 257
Cdd:TIGR01726  83 IALTLFYGAYLAEIFRG 99
artM PRK11122
arginine ABC transporter permease ArtM;
162-363 5.91e-10

arginine ABC transporter permease ArtM;


Pssm-ID: 182978 [Multi-domain]  Cd Length: 222  Bit Score: 58.82  E-value: 5.91e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506403442 162 GGLPLTMLLFTGTVLIGMPVAVLLALGRRAPLPVARGVSVVFIEALRGVPLITILFVaVNVFPLFLPAGVEVNKL----- 236
Cdd:PRK11122  10 KGLHTSLTLTVASLLVALVLALIFTIILTLKTPVLVWLVRGYITLFTGTPLLVQIFL-IYYGPGQFPWLQEYPWLwhlls 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506403442 237 ---LRITVGIAIFFACYQAEVIRGGLQAIPTGQYEAAASLSLSYWQTTrRIILPQALRISLPAITNHIIAAMKNTSFVII 313
Cdd:PRK11122  89 qpwLCAMLALALNSAAYSTQLFYGAVRAIPEGQWQSCAALGMSKKQTL-RILLPYAFKRALSSYSNEVVLVFKSTSLAYT 167

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 506403442 314 IGLFDILTATtavmQDPLWRKFYIEAYLFVAAVYLFFGYALSLYARQVEK 363
Cdd:PRK11122 168 ITLMDVMGYS----QLLYGRTYDVMVFGAAGIIYLVVNGLLTLLMRLIER 213
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 178-365 1.27e-07

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 51.15  E-value: 1.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506403442  178 GMPVAVLLALGRRAPLpvaRGVSVVFIEALRGVPLITILFVAVNVFPLFLPAGVEVNKLLRITVGIAIFFAcyqaEVIRG 257
Cdd:pfam00528   1 GIPLGIIAALRRGRRL---DRLLRPLIDLLQALPSFVLAILLVVIAILSILGHGILPAIILALLGWAGYAR----LIRRA 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506403442  258 GLQAIPTGQYEAAASLSLSYWQTTRRIILPQALRISLPAITNHIIAAMKNTSFVIIIGLFDILTATTAVMQDPLWRKFYI 337
Cdd:pfam00528  74 ALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGLLLIEAILGYDYPEIQ 153

                         170       180
                  ....*....|....*....|....*...
gi 506403442  338 EAYLFVAAVYLFFGYALSLYARQVEKWI 365
Cdd:pfam00528 154 GPVLAAALILLLLNLLVDILQRLLDPRV 181
TauC COG0600
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ...
 175-290 6.72e-06

ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440365 [Multi-domain]  Cd Length: 254  Bit Score: 47.06  E-value: 6.72e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506403442 175 VLIGMPVAVLLALgrrapLPVARGVSVVFIEALRGVPLITILFVAVNVFPLFLPAGVevnkllrITVGIAIFFACYQAev 254
Cdd:COG0600   78 ALLGVPLGLLLGL-----SRLLRRLLDPLLVFLRPIPPLALAPLLILWFGIGEASKI-------FVIFLGAFFPILLN-- 143

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 506403442 255 IRGGLQAIPTGQYEAAASLSLSYWQTTRRIILPQAL 290
Cdd:COG0600  144 TAAGVRSVDPELLELARSLGASRWQILRKVVLPAAL 179
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
173-291 9.86e-03

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 37.83  E-value: 9.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506403442 173 GTVLIGMPVAVLLAlgrRAPLPVARGVSVVFIealrgVPLITILFVAVNVFPLFLPAGVEVNKLLRITVGI--------- 243
Cdd:COG1178   69 LSLLLGVPLAWLLA---RTDFPGRRLLRWLLL-----LPLALPPYVVALAWIALFGPNGLLNTLLRALFGLeppdiyglg 140

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 506403442 244 ------AIFFACYQAEVIRGGLQAIPTGQYEAAASLSLSYWQTTRRIILPQALR 291
Cdd:COG1178  141 giilvlVLFNYPYVYLLLRAALRSIDASLEEAARSLGASPWRAFRRVTLPLLRP 194
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH