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Conserved domains on  [gi|505740940|ref|WP_015702573|]
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6-phosphogluconolactonase [Pasteurella multocida]

Protein Classification

6-phosphogluconolactonase( domain architecture ID 10471859)

6-phosphogluconolactonase catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate, which is the the second step of the oxidative phase of the pentose phosphate pathway

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
9-222 5.89e-79

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


:

Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 236.36  E-value: 5.89e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940    9 AQHAVEKIAQELLAYSLEGRPVHISLSGGSTPKLLFKTLAQAPYntEIQWKNLHFWWGDDRMVPPTDPESNYGEVQKLLF 88
Cdd:pfam01182   7 AQALAERLAEALEAALAERGRFTLALSGGSTPKPLYELLAAAPA--RLDWSRVHVFWGDERCVPPDDPDSNYGMAREALL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940   89 DHIQIPAENIHRIRGEAP-VESELHRFEQALSAVIPGQ---VFDWIILGMGTDGHTASLFPHQTDF--DDPHFAVIAKHP 162
Cdd:pfam01182  85 SHVPIPASNVHPIPASAAdPEEAAAAYEAELRELLPDLelpVFDLVLLGMGPDGHTASLFPGSPALeeTDRLVVAVTDSP 164

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940  163 ETGQIRISKTAKLIEQAKRVTYLVTGSSKAEILKEIQTTPAEqlPYPAAKIKAKHGVTEW 222
Cdd:pfam01182 165 KPPPERITLTLPVLNAARRVWFLVTGAGKADALRRALAGDPD--PLPAALVRPGAGETVW 222
 
Name Accession Description Interval E-value
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
9-222 5.89e-79

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 236.36  E-value: 5.89e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940    9 AQHAVEKIAQELLAYSLEGRPVHISLSGGSTPKLLFKTLAQAPYntEIQWKNLHFWWGDDRMVPPTDPESNYGEVQKLLF 88
Cdd:pfam01182   7 AQALAERLAEALEAALAERGRFTLALSGGSTPKPLYELLAAAPA--RLDWSRVHVFWGDERCVPPDDPDSNYGMAREALL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940   89 DHIQIPAENIHRIRGEAP-VESELHRFEQALSAVIPGQ---VFDWIILGMGTDGHTASLFPHQTDF--DDPHFAVIAKHP 162
Cdd:pfam01182  85 SHVPIPASNVHPIPASAAdPEEAAAAYEAELRELLPDLelpVFDLVLLGMGPDGHTASLFPGSPALeeTDRLVVAVTDSP 164

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940  163 ETGQIRISKTAKLIEQAKRVTYLVTGSSKAEILKEIQTTPAEqlPYPAAKIKAKHGVTEW 222
Cdd:pfam01182 165 KPPPERITLTLPVLNAARRVWFLVTGAGKADALRRALAGDPD--PLPAALVRPGAGETVW 222
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
 9-224 3.09e-78

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 234.38  E-value: 3.09e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940   9 AQHAVEKIAQELLAYSLEGRPVHISLSGGSTPKLLFKTLAQAPyntEIQWKNLHFWWGDDRMVPPTDPESNYGEVQKLLF 88
Cdd:cd01400    4 AEALADRIAEALAAAIAKRGRFSLALSGGSTPKPLYELLAAAP---ALDWSKVHVFLGDERCVPPDDPDSNYRLAREALL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940  89 DHIQIPAENIHRIRGEAPVESELHRFEQALSAVIPG-QVFDWIILGMGTDGHTASLFPHQTDFD-DPHFAVIAKH--PET 164
Cdd:cd01400   81 SHVAIPAANIHPIPTELGPEDAAAAYEKELRALFGGvPPFDLVLLGMGPDGHTASLFPGHPALLeETDRLVVAVTdsPKP 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940 165 GQIRISKTAKLIEQAKRVTYLVTGSSKAEILKEIQTTPAEQlPYPAAKIKAKHGVTEWYL 224
Cdd:cd01400  161 PPERITLTLPVLNNARRVVFLVTGAEKAEALKRALAGPDPE-ELPAARVLPRPGEVLWFL 219
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 1-232 5.76e-67

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 206.55  E-value: 5.76e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940   1 MNTIIFDS----AQHAVEKIAQELLAYSLEGRPVHISLSGGSTPKLLFKTLAQAPYNTEIQWKNLHFWWGDDRM-VPPTD 75
Cdd:COG0363    2 MRVIIFPDaeelAAAAAERAAERIAEAIAEKGRAVLGLAGGSTPLGLYEELARLHKEGGLDWSRVHVFNLDEYVgLPPDH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940  76 PESNYGEVQKLLFDHIQIPAENIHRIRGEAP-VESELHRFEQALSAVIPgqvFDWIILGMGTDGHTASLFPHqTDFDDPH 154
Cdd:COG0363   82 PQSNRRFMREALLDHVDIPPENIHIPDGEAEdPEAAAARYEALIAEAGG---IDLQLLGIGEDGHIAFNFPG-SPFLSET 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940 155 FAVIAKHPETGQI--------------RISKTAKLIEQAKRVTYLVTGSSKAEILKEIQTTPAEQLpYPAAKIKaKHGVT 220
Cdd:COG0363  158 DRVVTLDESTRQAnarffgsipkvppqAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEE-VPASILQ-GHPNV 235

                        250
                 ....*....|..
gi 505740940 221 EWYLDKDAAKLL 232
Cdd:COG0363  236 TWFLDEAAASLL 247
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 5-232 2.22e-55

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 176.80  E-value: 2.22e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940    5 IFDSAQHAVEKIAQELL-----AYSLEGRpVHISLSGGSTPKLLFKTLAQAPynteIQWKNLHFWWGDDRMVPPTDPESN 79
Cdd:TIGR01198   1 VFSNSAELAEALAERIAtklqtALAERGQ-FSLALSGGRSPIALLEALAAQP----LDWSRIHLFLGDERYVPLDHADSN 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940   80 YGEVQKLLFDHIQIPAENIHRIRGEAP-VESELHRFEQALSA---VIPGQVFDWIILGMGTDGHTASLFPHQTDFD--DP 153
Cdd:TIGR01198  76 TGLAREALLDRVAIPASNIHPMPTELSdIEEAAELYEQELAAafqPIVFPVFDLLLLGMGPDGHTASLFPHTPALQetER 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505740940  154 HFAVIAKHPETGQIRISKTAKLIEQAKRVTYLVTGSSKAEILKEIQTTPAEQLPYPAAKIKaKHGVTEWYLDKDAAKLL 232
Cdd:TIGR01198 156 LVTVLTKSPKPPHERITLTLPAINAARKVFLLIAGEEKRNALAEALAVEAEPYPLPAAGVL-HSGKTLWLLDYAAARKL 233
PLN02360 PLN02360
probable 6-phosphogluconolactonase
 32-232 1.20e-27

probable 6-phosphogluconolactonase


Pssm-ID: 166001 [Multi-domain]  Cd Length: 268  Bit Score: 106.10  E-value: 1.20e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940  32 ISLSGGSTPKLLFKtLAQAPYNTEIQWKNLHFWWGDDRMVPPTDPESNYGEVQKLLFDHIQIPAENIHRIRGEAPVESEL 111
Cdd:PLN02360  46 IALSGGSLISFMGK-LCEAPYNKTVDWAKWYIFWADERVVAKNHADSNYKLAKDGLLSKVPVVPSHVYSINDTVTAEEAA 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940 112 HRFEQALSAVIPGQV-----------FDWIILGMGTDGHTASLFPHQT--DFDDPHFAVIAKHPETGQIRISKTAKLIEQ 178
Cdd:PLN02360 125 TDYEFAIRQLVKTRTigvsdisdcpkFDLILLGMGSDGHVASLFPNHPalEEKDDWVTFITDSPKPPPERITFTLPVINS 204

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 505740940 179 AKRVTYLVTGSSKAEILK---EIQTTPAEQLPYPAAKIKAKHGVTEWYLDKDAAKLL 232
Cdd:PLN02360 205 ASNVAVVATGESKANAVHlaiDDVTEGPDAPSLPARMVQPTKGKLVWFLDKPAASKL 261
 
Name Accession Description Interval E-value
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
9-222 5.89e-79

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 236.36  E-value: 5.89e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940    9 AQHAVEKIAQELLAYSLEGRPVHISLSGGSTPKLLFKTLAQAPYntEIQWKNLHFWWGDDRMVPPTDPESNYGEVQKLLF 88
Cdd:pfam01182   7 AQALAERLAEALEAALAERGRFTLALSGGSTPKPLYELLAAAPA--RLDWSRVHVFWGDERCVPPDDPDSNYGMAREALL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940   89 DHIQIPAENIHRIRGEAP-VESELHRFEQALSAVIPGQ---VFDWIILGMGTDGHTASLFPHQTDF--DDPHFAVIAKHP 162
Cdd:pfam01182  85 SHVPIPASNVHPIPASAAdPEEAAAAYEAELRELLPDLelpVFDLVLLGMGPDGHTASLFPGSPALeeTDRLVVAVTDSP 164

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940  163 ETGQIRISKTAKLIEQAKRVTYLVTGSSKAEILKEIQTTPAEqlPYPAAKIKAKHGVTEW 222
Cdd:pfam01182 165 KPPPERITLTLPVLNAARRVWFLVTGAGKADALRRALAGDPD--PLPAALVRPGAGETVW 222
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
 9-224 3.09e-78

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 234.38  E-value: 3.09e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940   9 AQHAVEKIAQELLAYSLEGRPVHISLSGGSTPKLLFKTLAQAPyntEIQWKNLHFWWGDDRMVPPTDPESNYGEVQKLLF 88
Cdd:cd01400    4 AEALADRIAEALAAAIAKRGRFSLALSGGSTPKPLYELLAAAP---ALDWSKVHVFLGDERCVPPDDPDSNYRLAREALL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940  89 DHIQIPAENIHRIRGEAPVESELHRFEQALSAVIPG-QVFDWIILGMGTDGHTASLFPHQTDFD-DPHFAVIAKH--PET 164
Cdd:cd01400   81 SHVAIPAANIHPIPTELGPEDAAAAYEKELRALFGGvPPFDLVLLGMGPDGHTASLFPGHPALLeETDRLVVAVTdsPKP 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940 165 GQIRISKTAKLIEQAKRVTYLVTGSSKAEILKEIQTTPAEQlPYPAAKIKAKHGVTEWYL 224
Cdd:cd01400  161 PPERITLTLPVLNNARRVVFLVTGAEKAEALKRALAGPDPE-ELPAARVLPRPGEVLWFL 219
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 1-232 5.76e-67

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 206.55  E-value: 5.76e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940   1 MNTIIFDS----AQHAVEKIAQELLAYSLEGRPVHISLSGGSTPKLLFKTLAQAPYNTEIQWKNLHFWWGDDRM-VPPTD 75
Cdd:COG0363    2 MRVIIFPDaeelAAAAAERAAERIAEAIAEKGRAVLGLAGGSTPLGLYEELARLHKEGGLDWSRVHVFNLDEYVgLPPDH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940  76 PESNYGEVQKLLFDHIQIPAENIHRIRGEAP-VESELHRFEQALSAVIPgqvFDWIILGMGTDGHTASLFPHqTDFDDPH 154
Cdd:COG0363   82 PQSNRRFMREALLDHVDIPPENIHIPDGEAEdPEAAAARYEALIAEAGG---IDLQLLGIGEDGHIAFNFPG-SPFLSET 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940 155 FAVIAKHPETGQI--------------RISKTAKLIEQAKRVTYLVTGSSKAEILKEIQTTPAEQLpYPAAKIKaKHGVT 220
Cdd:COG0363  158 DRVVTLDESTRQAnarffgsipkvppqAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEE-VPASILQ-GHPNV 235

                        250
                 ....*....|..
gi 505740940 221 EWYLDKDAAKLL 232
Cdd:COG0363  236 TWFLDEAAASLL 247
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 5-232 2.22e-55

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 176.80  E-value: 2.22e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940    5 IFDSAQHAVEKIAQELL-----AYSLEGRpVHISLSGGSTPKLLFKTLAQAPynteIQWKNLHFWWGDDRMVPPTDPESN 79
Cdd:TIGR01198   1 VFSNSAELAEALAERIAtklqtALAERGQ-FSLALSGGRSPIALLEALAAQP----LDWSRIHLFLGDERYVPLDHADSN 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940   80 YGEVQKLLFDHIQIPAENIHRIRGEAP-VESELHRFEQALSA---VIPGQVFDWIILGMGTDGHTASLFPHQTDFD--DP 153
Cdd:TIGR01198  76 TGLAREALLDRVAIPASNIHPMPTELSdIEEAAELYEQELAAafqPIVFPVFDLLLLGMGPDGHTASLFPHTPALQetER 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505740940  154 HFAVIAKHPETGQIRISKTAKLIEQAKRVTYLVTGSSKAEILKEIQTTPAEQLPYPAAKIKaKHGVTEWYLDKDAAKLL 232
Cdd:TIGR01198 156 LVTVLTKSPKPPHERITLTLPAINAARKVFLLIAGEEKRNALAEALAVEAEPYPLPAAGVL-HSGKTLWLLDYAAARKL 233
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 10-232 4.55e-29

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 108.73  E-value: 4.55e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940  10 QHAVEKIAQELLAYSLEGRPVHISLSGGSTPKLLFKTLAQAPYNTEIQWKNLHF-----WWGddrmVPPTDPESNYGEVQ 84
Cdd:cd01399    1 EEMSEAAAELIAELIREKPPAVLGLATGSTPLGVYEELIELHKEGGLSFSNVTTfnldeYVG----LPPDHPQSYHYFMR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940  85 KLLFDHIQIPAENIHRIRGEAP-VESELHRFEQALSAVIPGqvfDWIILGMGTDGHTA-----SLFPHQT---------- 148
Cdd:cd01399   77 ENLFDHIDIKPENIHIPDGNAAdLEAECRRYEALIAEAGGI---DLQLLGIGENGHIGfnepgSSLDSRTrvvtldestr 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940 149 -------DFDD--PHFAviakhpetgqirISKTAKLIEQAKRVTYLVTGSSKAEILKE-IQTTPAEQLPypaAKIKAKHG 218
Cdd:cd01399  154 qanarffDGDEdvPTQA------------ITMGIGTIMKAKEILLLATGEGKAEAVKKaLEGPVTEECP---ASILQLHP 218

                        250
                 ....*....|....
gi 505740940 219 VTEWYLDKDAAKLL 232
Cdd:cd01399  219 NVTVILDEAAASEL 232
PLN02360 PLN02360
probable 6-phosphogluconolactonase
 32-232 1.20e-27

probable 6-phosphogluconolactonase


Pssm-ID: 166001 [Multi-domain]  Cd Length: 268  Bit Score: 106.10  E-value: 1.20e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940  32 ISLSGGSTPKLLFKtLAQAPYNTEIQWKNLHFWWGDDRMVPPTDPESNYGEVQKLLFDHIQIPAENIHRIRGEAPVESEL 111
Cdd:PLN02360  46 IALSGGSLISFMGK-LCEAPYNKTVDWAKWYIFWADERVVAKNHADSNYKLAKDGLLSKVPVVPSHVYSINDTVTAEEAA 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940 112 HRFEQALSAVIPGQV-----------FDWIILGMGTDGHTASLFPHQT--DFDDPHFAVIAKHPETGQIRISKTAKLIEQ 178
Cdd:PLN02360 125 TDYEFAIRQLVKTRTigvsdisdcpkFDLILLGMGSDGHVASLFPNHPalEEKDDWVTFITDSPKPPPERITFTLPVINS 204

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 505740940 179 AKRVTYLVTGSSKAEILK---EIQTTPAEQLPYPAAKIKAKHGVTEWYLDKDAAKLL 232
Cdd:PLN02360 205 ASNVAVVATGESKANAVHlaiDDVTEGPDAPSLPARMVQPTKGKLVWFLDKPAASKL 261
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
 1-232 4.43e-18

glucosamine-6-phosphate deaminase; Provisional


Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 80.26  E-value: 4.43e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940   1 MNTIIFD--------SAQHAVEKIAQELLAyslEGRPVHISLSGGSTPKLLFKTLAQAPYNTEIQWKNLHFWWGDDRM-V 71
Cdd:PRK00443   1 MRLIILKtaeevgkwAARHIANRINAFLPT---KERPFVLGLATGSSPLETYKALIELHKAGKVDFSRVTTFNLDEYVgL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940  72 PPTDPESNYGEVQKLLFDHIQIPAENIHRIRGEAP-VESELHRFEQALSAVIPGQVFdwiILGMGTDGHTA-----SLFP 145
Cdd:PRK00443  78 PADHPESYRYFMRENFFDHVDIPPENINLLNGNAPdPEAECRRYEEKIKSAGGIDLQ---ILGIGENGHIAfnepgSSFA 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940 146 HQT-------------------DFDD-PHFAviakhpetgqirISKTAKLIEQAKRVTYLVTGSSKAEILKE-IQTTPAE 204
Cdd:PRK00443 155 SRTriktltedtriansrffdgDIEQvPKYA------------LTVGVGTILDAKEIMLLAPGHNKAEAVKAaVEGPVNH 222

                        250       260
                 ....*....|....*....|....*...
gi 505740940 205 QLPypaAKIKAKHGVTEWYLDKDAAKLL 232
Cdd:PRK00443 223 MWP---ASILQLHPKATLVLDEAAASEL 247
PTZ00285 PTZ00285
glucosamine-6-phosphate isomerase; Provisional
 1-232 5.37e-18

glucosamine-6-phosphate isomerase; Provisional


Pssm-ID: 140308  Cd Length: 253  Bit Score: 79.80  E-value: 5.37e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940   1 MNTIIFDSAQHAVEKIAQELLAYSLE-----GRPVHISLSGGSTPKLLFKTLAQAPYNTEIQWKNLHFWWGDDRM-VPPT 74
Cdd:PTZ00285   1 MRIVISEDADAVADYTSNYIIKRINDfkptsDRPFVLGLPTGSTPLPTYQELIRAYREGRVSFSNVVTFNMDEYVgLPRD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940  75 DPESNYGEVQKLLFDHIQIPAENIHRIRGEAP-VESELHRFEQALSAVIPGQVFdwiILGMGTDGHTAslfphqtdFDDP 153
Cdd:PTZ00285  81 HPQSYHYFMKENFFDHVDIKEENRHILNGTAPdLEEECRRYEEKIRAVGGIDLF---LAGIGTDGHIA--------FNEP 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940 154 ------HFAVIAKHPET---------GQIRISKTAKL------IEQAKRVTYLVTGSSKAEIL-KEIQTTPAEQLPYPAA 211
Cdd:PTZ00285 150 gssldsRTRVKSLNQETidanarffgNDISKVPTMALtvgirtIMEAREVLLLATGASKAIAVaRCVEGGVTHMCPASAL 229

                        250       260
                 ....*....|....*....|.
gi 505740940 212 KIkakHGVTEWYLDKDAAKLL 232
Cdd:PTZ00285 230 QM---HPAAVLCLDEDATLEL 247
PRK12358 PRK12358
glucosamine-6-phosphate deaminase;
1-232 6.56e-18

glucosamine-6-phosphate deaminase;


Pssm-ID: 183470  Cd Length: 239  Bit Score: 79.41  E-value: 6.56e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940   1 MNTIIFDSAQHAVEKIAQELLAYSLEGRPVHISLSGGSTPKLLFKTLAqAPYNTEIQWKNLHFWWGDDrmvPPTDPESNY 80
Cdd:PRK12358   1 MKIIITKDYEEMSRVAAHHLLGYMSKTKRVNLAITAGSTPKGMYEYLI-TLVKGKAWYDNVHYYNFDE---IPFRGKEGE 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940  81 G----EVQKLLFDHIQIPAENIHRIRGEAPVEselhrFEQALSAVipGQVfDWIILGMGTDGHTASLFPHQTDFDDPHFA 156
Cdd:PRK12358  77 GvtitNLRNLFFTPAGIKEENIHKLTIDNYRE-----HDQKLARD--GGL-DLVVLGLGADGHFCGNLPGTTHFHDETVE 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940 157 V--------IAKHPETGQiRISKTA--------KLIEQAKRVTYLVTGSSKAEILKEIQTTP-AEQLPypaAKIKAKHGV 219
Cdd:PRK12358 149 VpiqgemvdIVAHGELGG-DFSLVPdsyvtmgpKSIMAAKNLLLIVNGKGKAQILKKVLQGPvTEDVP---ASILQLHPN 224

                        250
                 ....*....|...
gi 505740940 220 TEWYLDKDAAKLL 232
Cdd:PRK12358 225 LTVILDEAAAAEL 237
SugarP_isomerase cd00458
SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate ...
 9-140 1.53e-17

SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium, the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate. 6PGL converts 6-phosphoglucono-1,5-lactone to 6-phosphogluconate, the second step of the oxidative phase of the pentose phosphate pathway.


Pssm-ID: 238258  Cd Length: 169  Bit Score: 77.01  E-value: 1.53e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940   9 AQHAVEKIAQELLAYSLEGRPVHISLSGGSTPKLLFKTLAQAPYNTEiqWKNLHFWWGDDRMVPPTDPESNYGEVQKLLF 88
Cdd:cd00458    1 AKEALKFIEDK*EKLLEEKDDMVIGLGTGSTPAYFYKLLGEKLKRGE--ISDIVGFPTDERYVPLDSDQSNFRQAKLLAF 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 505740940  89 DHIQIPAENIHRIRGEAPVE-SELHRFEQALSAVipgQVFDWIILGMGTDGHT 140
Cdd:cd00458   79 EHDIIPASNVHYVDTSLPIEkACEKYEREILDQV---DAIDLAVDGAGYRAGT 128
PRK02122 PRK02122
glucosamine-6-phosphate deaminase-like protein; Validated
 3-232 6.29e-15

glucosamine-6-phosphate deaminase-like protein; Validated


Pssm-ID: 235005 [Multi-domain]  Cd Length: 652  Bit Score: 73.14  E-value: 6.29e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940   3 TIIFDSAQHAVEKIAQELLAY----SLEGRPVHISLSGGSTPKLLFKTLAQAPYNTEIQWKNlhfwwgddrMVP------ 72
Cdd:PRK02122  30 TDIFESSEEASRAVAQEIATLirerQAEGKPCVLGLATGSSPIGVYAELIRMHREEGLSFKN---------VITfnldey 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940  73 -PTDPESNYGEVQKL---LFDHIQIPAENIHRIRGEAP---VESELHRFEQALSAVipGQVfDWIILGMGTDGHTASLFP 145
Cdd:PRK02122 101 yPMQPDSLQSYHRFMkenLFDHVDIPPENIHIPDGTIPkeeIDEYCRDYEEKIEAA--GGI-DFQLLGIGRTGHIGFNEP 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940 146 --------------HQTDFD-DPHFAVIAKHPETGqirISKTAKLIEQAKRVTYLVTGSSKAEILKE-IQTTPAEQLPyp 209
Cdd:PRK02122 178 gsgrnsrtrlvtldHITRRDaASDFFGEENVPRKA---ITMGVGTILKARRIVLLAWGEHKAPIIKRaVEGEISDEVP-- 252

                        250       260
                 ....*....|....*....|...
gi 505740940 210 aAKIKAKHGVTEWYLDKDAAKLL 232
Cdd:PRK02122 253 -ASYLQEHPNATFVLDLAAASEL 274
PRK09762 PRK09762
galactosamine-6-phosphate isomerase; Provisional
 32-194 3.55e-05

galactosamine-6-phosphate isomerase; Provisional


Pssm-ID: 182064  Cd Length: 232  Bit Score: 43.66  E-value: 3.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940  32 ISLSGGSTPKLLFKTLAQAPYNTEIQWKNLHFW----WGDdrmVPPTDPESNYGEVQKLLFDHIQIPAENIHRIRGEAPV 107
Cdd:PRK09762  32 ICLATGATPLLTYHYLVEKIHQQQVDVSQLTFVkldeWVD---LPLTMPGTCETFLQQHIVQPLGLREDQLISFRSEEIN 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505740940 108 ESELHRFEQALSAVIPgqvFDWIILGMGTDGH------TASLFP--HQTDFDD-----PHFAVIAKHPETGqirISKTAK 174
Cdd:PRK09762 109 ETECERVTNLIARKGG---LDLCVLGLGKNGHlglnepGESLQPacHISQLDArtqqhEMLKTAGRPVTRG---ITLGLK 182

                        170       180
                 ....*....|....*....|
gi 505740940 175 LIEQAKRVTYLVTGSSKAEI 194
Cdd:PRK09762 183 DILNAREVLLLVTGEGKQDA 202
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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