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Conserved domains on  [gi|505248083|ref|WP_015435185|]
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methanol/ethanol family PQQ-dependent dehydrogenase [Azoarcus sp. KH32C]

Protein Classification

methanol/ethanol family PQQ-dependent dehydrogenase( domain architecture ID 10178893)

methanol/ethanol family PQQ-dependent dehydrogenase similar to Thauera butanivorans 1-butanol dehydrogenase (quinone) that catalyzes the oxidation of 1-butanol to 1-butanal and may function primarily in energy generation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PQQ_ADH_I cd10277
Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); ...
 45-594 0e+00

Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); This bacterial family of homodimeric ethanol dehydrogenases utilize pyrroloquinoline quinone (PQQ) as a cofactor. It represents proteins whose expression may be induced by ethanol, and which are similar to quinoprotein methanol dehydrogenases, but have higher specificities for ethanol and other primary and secondary alcohols. Dehydrogenases with PQQ cofactors, such as ethanol, methanol, and membrane-bound glucose dehydrogenases, form an 8-bladed beta-propeller.


:

Pssm-ID: 199835 [Multi-domain]  Cd Length: 529  Bit Score: 863.53  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  45 TSQVVTYGLGTKGQRFSPLAKVNTSTVKNLVPVWSFSFGGeKQRGQQSQPIVFDGKMYVTASYSRIFALDMKTGEKLWKY 124
Cdd:cd10277    8 TGNWLTYGRGYNGQRYSPLKQINTDNVKNLVPAWSFSFGG-KQRGQESQPIVNDGVMYVTTSYNRVFAIDAKTGKELWKY 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 125 EHRLPEGIMPCCDVINRGAAIYGNLVIFGTLDAQLVALDKDTGKVVWKEKIEDYKGGYSFTAAPQIVKGMVITGVSGGEF 204
Cdd:cd10277   87 KHRLPEDIRPCCDVVNRGVALYGDKVYFGTLDAHLVALDAKTGKVVWKKKVADYKAGYSMTLAPLVVKGKVIVGVSGGEF 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 205 GIVGKVEARDAKTGKLVWSRPTVEGNMGYKYDKdgkeiengvsgttnaTWPGDLWKSGGAAPWLSAYYDPEVNLIFIGTG 284
Cdd:cd10277  167 GVRGFIAALDAETGKEVWRTYTVPGPGEPGSTD---------------TWPGDAWKTGGGATWLTGTYDPETNLLYWGVG 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 285 NPAPWNSWLRPGDNLYSSSTVAIDPDTGKIVWHYQTTPHDGWDFDGVNEFVSFDYkdPKTGKMVKAGGKADRNGFFFVND 364
Cdd:cd10277  232 NPAPWNGDLRPGDNLYTSSVLALDPDTGKIKWHYQYTPNDTWDYDGVNEPVLFDY--TKNGKPVKALVHADRNGFFYVLD 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 365 RTNGKLLNAFPFVNRHDWAdRIDLATGRPVYNDSKRPPnpfveggegKKGESIFAAPSFLGGKNQMPMAYSPKTGYFYVP 444
Cdd:cd10277  310 RTNGKLIWATPFVKKITWA-SIDLKTGRPIYDEDKVPP---------KKGKTVDFCPSFLGGKNWPPMAYSPDTGLFYVP 379

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 445 SNEWGMDIWNEPVSYKRGAAYLGAGFTIKPLNDDYIGALRAVDPVSGKIMWEVKNNAPLWGGVLATGGDLVFYGTPEGYL 524
Cdd:cd10277  380 ANHWCMDLTGEPVSYKKGAAYLGAGFTIKPPFEDHIGELQAIDPTTGKKVWEHKTPLPLWGGVLTTAGGLVFTGTPDGYF 459

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 525 KAINAKTGAELWKFQTGSGIIAPPITWEDNGEQYVAVVSGWGGAVPLWGGDVAKRVNMLEQGGSVWVFKL 594
Cdd:cd10277  460 RAFDAKTGKELWEFQTGSGIIGPPVTWEVDGKQYVAVLSGWGGAAPLWGGDMAKLLKNVPQGGSLWVFAL 529
 
Name Accession Description Interval E-value
PQQ_ADH_I cd10277
Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); ...
 45-594 0e+00

Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); This bacterial family of homodimeric ethanol dehydrogenases utilize pyrroloquinoline quinone (PQQ) as a cofactor. It represents proteins whose expression may be induced by ethanol, and which are similar to quinoprotein methanol dehydrogenases, but have higher specificities for ethanol and other primary and secondary alcohols. Dehydrogenases with PQQ cofactors, such as ethanol, methanol, and membrane-bound glucose dehydrogenases, form an 8-bladed beta-propeller.


Pssm-ID: 199835 [Multi-domain]  Cd Length: 529  Bit Score: 863.53  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  45 TSQVVTYGLGTKGQRFSPLAKVNTSTVKNLVPVWSFSFGGeKQRGQQSQPIVFDGKMYVTASYSRIFALDMKTGEKLWKY 124
Cdd:cd10277    8 TGNWLTYGRGYNGQRYSPLKQINTDNVKNLVPAWSFSFGG-KQRGQESQPIVNDGVMYVTTSYNRVFAIDAKTGKELWKY 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 125 EHRLPEGIMPCCDVINRGAAIYGNLVIFGTLDAQLVALDKDTGKVVWKEKIEDYKGGYSFTAAPQIVKGMVITGVSGGEF 204
Cdd:cd10277   87 KHRLPEDIRPCCDVVNRGVALYGDKVYFGTLDAHLVALDAKTGKVVWKKKVADYKAGYSMTLAPLVVKGKVIVGVSGGEF 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 205 GIVGKVEARDAKTGKLVWSRPTVEGNMGYKYDKdgkeiengvsgttnaTWPGDLWKSGGAAPWLSAYYDPEVNLIFIGTG 284
Cdd:cd10277  167 GVRGFIAALDAETGKEVWRTYTVPGPGEPGSTD---------------TWPGDAWKTGGGATWLTGTYDPETNLLYWGVG 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 285 NPAPWNSWLRPGDNLYSSSTVAIDPDTGKIVWHYQTTPHDGWDFDGVNEFVSFDYkdPKTGKMVKAGGKADRNGFFFVND 364
Cdd:cd10277  232 NPAPWNGDLRPGDNLYTSSVLALDPDTGKIKWHYQYTPNDTWDYDGVNEPVLFDY--TKNGKPVKALVHADRNGFFYVLD 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 365 RTNGKLLNAFPFVNRHDWAdRIDLATGRPVYNDSKRPPnpfveggegKKGESIFAAPSFLGGKNQMPMAYSPKTGYFYVP 444
Cdd:cd10277  310 RTNGKLIWATPFVKKITWA-SIDLKTGRPIYDEDKVPP---------KKGKTVDFCPSFLGGKNWPPMAYSPDTGLFYVP 379

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 445 SNEWGMDIWNEPVSYKRGAAYLGAGFTIKPLNDDYIGALRAVDPVSGKIMWEVKNNAPLWGGVLATGGDLVFYGTPEGYL 524
Cdd:cd10277  380 ANHWCMDLTGEPVSYKKGAAYLGAGFTIKPPFEDHIGELQAIDPTTGKKVWEHKTPLPLWGGVLTTAGGLVFTGTPDGYF 459

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 525 KAINAKTGAELWKFQTGSGIIAPPITWEDNGEQYVAVVSGWGGAVPLWGGDVAKRVNMLEQGGSVWVFKL 594
Cdd:cd10277  460 RAFDAKTGKELWEFQTGSGIIGPPVTWEVDGKQYVAVLSGWGGAAPLWGGDMAKLLKNVPQGGSLWVFAL 529
PQQ_enz_alc_DH TIGR03075
PQQ-dependent dehydrogenase, methanol/ethanol family; This protein family has a phylogenetic ...
 27-567 0e+00

PQQ-dependent dehydrogenase, methanol/ethanol family; This protein family has a phylogenetic distribution very similar to that coenzyme PQQ biosynthesis enzymes, as shown by partial phylogenetic profiling. Genes in this family often are found adjacent to the PQQ biosynthesis genes themselves. An unusual, strained disulfide bond between adjacent Cys residues contributes to PQQ-binding, as does a Trp residue that is part of a PQQ enzyme repeat (see pfam01011). Characterized members include the dehydrogenase subunit of a membrane-anchored, three subunit alcohol (ethanol) dehydrogenase of Gluconobacter suboxydans, a homodimeric ethanol dehydrogenase in Pseudomonas aeruginosa, and the large subunit of an alpha2/beta2 heterotetrameric methanol dehydrogenase in Methylobacterium extorquens.


Pssm-ID: 274419 [Multi-domain]  Cd Length: 527  Bit Score: 849.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083   27 VQAREVTDNDILKDGTGiTSQVVTYGLGTKGQRFSPLAKVNTSTVKNLVPVWSFSFGgeKQRGQQSQPIVFDGKMYVTAS 106
Cdd:TIGR03075   1 AAAAAVTNEDLLNDAKD-PSDWLTYGGGYAGQRYSPLDQINTDNVKKLQPAWTFSLG--KQRGQESQPLVVDGVMYVTTS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  107 YSRIFALDMKTGEKLWKYEHRLPEGIMP--CCDVINRGAAIYGNLVIFGTLDAQLVALDKDTGKVVWKEKIEDYKGGYSF 184
Cdd:TIGR03075  78 YSRVYALDAKTGKILWKYDPKLPDDIIPvmCCDVVNRGAALYDGKVFFGTLDARLVALDAKTGKVVWSKKNGDYKKGYTI 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  185 TAAPQIVKGMVITGVSGGEFGIVGKVEARDAKTGKLVWSRPTVEGNMGYKYDKDGKeiengVSGTTNA-TWPGDLWKSGG 263
Cdd:TIGR03075 158 TAAPLVVKGKVITGISGGEFGVRGYVTAYDAKTGKLVWRRYTVPGDMGYLKKTGKP-----VGGDPGAkTWPGDAWKTGG 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  264 AAPWLSAYYDPEVNLIFIGTGNPAPWNSWLRPGDNLYSSSTVAIDPDTGKIVWHYQTTPHDGWDFDGVNEFVSFDYKdpK 343
Cdd:TIGR03075 233 GATWGTGSYDPETNLIYFGTGNPAPWNSHLRPGDNLYTSSIVARDPDTGKIKWHYQTTPHDEWDYDGVNEMILFDLK--K 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  344 TGKMVKAGGKADRNGFFFVNDRTNGKLLNAFPFVNRHDWADRIDLATGRPVYNDSKRPPnpfveggEGKKGESIFAAPSF 423
Cdd:TIGR03075 311 DGKPRKLLAHADRNGFFYVLDRTNGKLLSAEPFVDKVNWATGVDLKTGRPIEVPEARST-------DGKKGKPVEVCPGF 383

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  424 LGGKNQMPMAYSPKTGYFYVPSNEWGMDIWNEPVSYKRGAAYLGAGFTIKPLNDDYIGALRAVDPVSGKIMWEVKNNAPL 503
Cdd:TIGR03075 384 LGGKNWQPMAYSPKTGLFYVPANHVCMDYWPEKVSYKKGAAYLGAGFTIKPPPDDHIGSLIAWDPITGKIVWEHKEDFPL 463

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505248083  504 WGGVLATGGDLVFYGTPEGYLKAINAKTGAELWKFQTGSGIIAPPITWEDNGEQYVAVVSGWGG 567
Cdd:TIGR03075 464 WGGVLATAGDLVFTGTLEGYFKAFDAKTGEELWKFKTGSGIVGPPVTYEQDGKQYVAVLSGWGG 527
Gcd COG4993
Glucose dehydrogenase, PQQ-dependent [Carbohydrate transport and metabolism];
45-594 0e+00

Glucose dehydrogenase, PQQ-dependent [Carbohydrate transport and metabolism];


Pssm-ID: 444017 [Multi-domain]  Cd Length: 515  Bit Score: 721.56  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  45 TSQVVTYGLGTKGQRFSPLAKVNTSTVKNLVPVWSFSFGGEKQRGQQSQPIVFDGKMYVTASYSRIFALDMKTGEKLWKY 124
Cdd:COG4993    2 PGDWLAYGGDYAGQRYSPLDQINPDNVKKLKVAWTFSTGDLPERGHEATPLVVDGVLYVCTPHNRVFALDAATGKELWRY 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 125 EHRLPEGIMpCCDVINRGAAIYGNLVIFGTLDAQLVALDKDTGKVVWKEKIEDYKGGYSFTAAPQIVKGMVITGVSGGEF 204
Cdd:COG4993   82 DPKLPDDAA-CCDVVNRGVAYYDGRIFLGTLDGRLVALDAKTGKVCWDVKVGDPKKGYTITSAPLVVKDKVIVGGSGGEF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 205 GIVGKVEARDAKTGKLVWSRPTVEGNMGYKYDkdgkeiengvsgttnaTWP-GDLWKSGGAAPWLSAYYDPEVNLIFIGT 283
Cdd:COG4993  161 GPRGVVRAYDARTGKLVWRFDTIPDPGEPGAE----------------TWPpGDTWKRGGGNVWGTMSYDPELGLVYLPT 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 284 GNPAP-WNSWLRPGDNLYSSSTVAIDPDTGKIVWHYQTTPHDGWDFDGVNEFVSFDYkdPKTGKMVKAGGKADRNGFFFV 362
Cdd:COG4993  225 GNPAPdWNGGQRPGDNLYSSSIVALDADTGELKWHYQTVPHDLWDYDGPNEPILVDL--PVDGKTRKALVQATKNGFIYV 302

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 363 NDRTNGKLLNAFPFVNRHDWADRIDLATGRPVYNdskrPPnpfveggeGKKGESIFAAPSFLGGKNQMPMAYSPKTGYFY 442
Cdd:COG4993  303 LDRETGEPLVTQPFVKPPNWATEIDMWGATPIQT----PP--------SLDGKTTLICPGALGGKNWGPAAYDPETGLLY 370

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 443 VPSNEWGMDIWNEPVSYKRGAAYLGAGFTIKPLNDDYIGALRAVDPVSGKIMWEVKNNAPLWGGVLATGGDLVFYGTPEG 522
Cdd:COG4993  371 VPANELCMDYELVPREYQAGAPYLGATLTMYPCPAPPWGTLTAIDLNTGKIVWQVPLGFPNWGGPLATAGGLVFIGTLDG 450

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 505248083 523 YLKAINAKTGAELWKFQTGSGIIAPPITWEDNGEQYVAVVSGWGGAVPLWGGdvakrvnmLEQGGSVWVFKL 594
Cdd:COG4993  451 YLRAFDAKTGKELWKFRLPSGGQATPMTYEVDGKQYVAVAAGGGGWLGLGLY--------TPQGDYLIAFAL 514
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 76-225 1.13e-12

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 67.81  E-value: 1.13e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083   76 PVWSFSFGGEkqrgQQSQPIVFDGKMYVTASYSRIFALDMKTGEKLWKYEHRLPEGIMpccdVINRGAAIYGNLVIFGTL 155
Cdd:pfam13360  55 LLWRQTLSGE----VLGAPLVAGGRVFVVAGDGSLIALDAADGRRLWSYQRSGEPLAL----RSSGSPAVVGDTVVAGFS 126

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505248083  156 DAQLVALDKDTGKVVWKEKIEDYKGGYSF------TAAPQIVKGMVItgVSGGEfgivGKVEARDAKTGKLVWSRP 225
Cdd:pfam13360 127 SGKLVALDPATGKVRWEAPLAAPRGTNELerlvdiTGTPVVAGGRVF--ASAYQ----GRLVAFDAATGRRLWTRE 196
PRK11138 PRK11138
outer membrane biogenesis protein BamB; Provisional
 60-231 1.53e-10

outer membrane biogenesis protein BamB; Provisional


Pssm-ID: 236857 [Multi-domain]  Cd Length: 394  Bit Score: 63.41  E-value: 1.53e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  60 FSPLAKVN---TSTVknlvpVWSFSFG-GEKQRGQQSQPIVFDGKMYVTASYSRIFALDMKTGEKLWKYEHRLPEGIMPC 135
Cdd:PRK11138  32 MSPLPQVEnqfTPTT-----VWSTSVGdGVGDYYSRLHPAVAYNKVYAADRAGLVKALDADTGKEIWSVDLSEKDGWFSK 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 136 cdviNRGAAIYG------NLVIFGTLDAQLVALDKDTGKVVWKEKIedykGGYSFtAAPQIVKGMVITGVSGgefgivGK 209
Cdd:PRK11138 107 ----NKSALLSGgvtvagGKVYIGSEKGQVYALNAEDGEVAWQTKV----AGEAL-SRPVVSDGLVLVHTSN------GM 171

                        170       180
                 ....*....|....*....|..
gi 505248083 210 VEARDAKTGKLVWsrpTVEGNM 231
Cdd:PRK11138 172 LQALNESDGAVKW---TVNLDV 190
PQQ smart00564
beta-propeller repeat; Beta-propeller repeat occurring in enzymes with pyrrolo-quinoline ...
 94-124 1.65e-04

beta-propeller repeat; Beta-propeller repeat occurring in enzymes with pyrrolo-quinoline quinone (PQQ) as cofactor, in Ire1p-like Ser/Thr kinases, and in prokaryotic dehydrogenases.


Pssm-ID: 128836 [Multi-domain]  Cd Length: 33  Bit Score: 39.05  E-value: 1.65e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 505248083    94 PIVFDGKMYVTASYSRIFALDMKTGEKLWKY 124
Cdd:smart00564   2 VVLSDGTVYVGSTDGTLYALDAKTGEILWTY 32
PA2928_fam NF041516
PA2928 family protein; This family is named for the locus PA2928 of Pseudomonas aeroginosa ...
 106-202 9.33e-04

PA2928 family protein; This family is named for the locus PA2928 of Pseudomonas aeroginosa PAO1, as the family member most frequently cited in the literature, although PA2928 itself is significantly shorter at the N-terminus than most other members of this family, and is probably non-functional. WP_017001489.1 represents an intact equivalent to the PA2928 pseudogene.


Pssm-ID: 469402 [Multi-domain]  Cd Length: 345  Bit Score: 41.59  E-value: 9.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 106 SYSRIFALDMKTGEKLWKyeHRLPegimpccDVINRGAAIYG---NLVIFGTlDAQLVALDKDTGKVV-----WKEKIED 177
Cdd:NF041516  67 SQFRLAAVDLATGEKLWD--KKLS-------DELSWEAYLLGatdRYLYVAT-DKGLYVLDLATGKVVadekeLEGLGPA 136

                         90       100
                 ....*....|....*....|....*....
gi 505248083 178 YKGGYSFTAAPQIV----KGMVITGVSGG 202
Cdd:NF041516 137 LKDNLSAARAAYAYdddnRALYFYGLDGR 165
 
Name Accession Description Interval E-value
PQQ_ADH_I cd10277
Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); ...
 45-594 0e+00

Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); This bacterial family of homodimeric ethanol dehydrogenases utilize pyrroloquinoline quinone (PQQ) as a cofactor. It represents proteins whose expression may be induced by ethanol, and which are similar to quinoprotein methanol dehydrogenases, but have higher specificities for ethanol and other primary and secondary alcohols. Dehydrogenases with PQQ cofactors, such as ethanol, methanol, and membrane-bound glucose dehydrogenases, form an 8-bladed beta-propeller.


Pssm-ID: 199835 [Multi-domain]  Cd Length: 529  Bit Score: 863.53  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  45 TSQVVTYGLGTKGQRFSPLAKVNTSTVKNLVPVWSFSFGGeKQRGQQSQPIVFDGKMYVTASYSRIFALDMKTGEKLWKY 124
Cdd:cd10277    8 TGNWLTYGRGYNGQRYSPLKQINTDNVKNLVPAWSFSFGG-KQRGQESQPIVNDGVMYVTTSYNRVFAIDAKTGKELWKY 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 125 EHRLPEGIMPCCDVINRGAAIYGNLVIFGTLDAQLVALDKDTGKVVWKEKIEDYKGGYSFTAAPQIVKGMVITGVSGGEF 204
Cdd:cd10277   87 KHRLPEDIRPCCDVVNRGVALYGDKVYFGTLDAHLVALDAKTGKVVWKKKVADYKAGYSMTLAPLVVKGKVIVGVSGGEF 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 205 GIVGKVEARDAKTGKLVWSRPTVEGNMGYKYDKdgkeiengvsgttnaTWPGDLWKSGGAAPWLSAYYDPEVNLIFIGTG 284
Cdd:cd10277  167 GVRGFIAALDAETGKEVWRTYTVPGPGEPGSTD---------------TWPGDAWKTGGGATWLTGTYDPETNLLYWGVG 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 285 NPAPWNSWLRPGDNLYSSSTVAIDPDTGKIVWHYQTTPHDGWDFDGVNEFVSFDYkdPKTGKMVKAGGKADRNGFFFVND 364
Cdd:cd10277  232 NPAPWNGDLRPGDNLYTSSVLALDPDTGKIKWHYQYTPNDTWDYDGVNEPVLFDY--TKNGKPVKALVHADRNGFFYVLD 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 365 RTNGKLLNAFPFVNRHDWAdRIDLATGRPVYNDSKRPPnpfveggegKKGESIFAAPSFLGGKNQMPMAYSPKTGYFYVP 444
Cdd:cd10277  310 RTNGKLIWATPFVKKITWA-SIDLKTGRPIYDEDKVPP---------KKGKTVDFCPSFLGGKNWPPMAYSPDTGLFYVP 379

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 445 SNEWGMDIWNEPVSYKRGAAYLGAGFTIKPLNDDYIGALRAVDPVSGKIMWEVKNNAPLWGGVLATGGDLVFYGTPEGYL 524
Cdd:cd10277  380 ANHWCMDLTGEPVSYKKGAAYLGAGFTIKPPFEDHIGELQAIDPTTGKKVWEHKTPLPLWGGVLTTAGGLVFTGTPDGYF 459

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 525 KAINAKTGAELWKFQTGSGIIAPPITWEDNGEQYVAVVSGWGGAVPLWGGDVAKRVNMLEQGGSVWVFKL 594
Cdd:cd10277  460 RAFDAKTGKELWEFQTGSGIIGPPVTWEVDGKQYVAVLSGWGGAAPLWGGDMAKLLKNVPQGGSLWVFAL 529
PQQ_enz_alc_DH TIGR03075
PQQ-dependent dehydrogenase, methanol/ethanol family; This protein family has a phylogenetic ...
 27-567 0e+00

PQQ-dependent dehydrogenase, methanol/ethanol family; This protein family has a phylogenetic distribution very similar to that coenzyme PQQ biosynthesis enzymes, as shown by partial phylogenetic profiling. Genes in this family often are found adjacent to the PQQ biosynthesis genes themselves. An unusual, strained disulfide bond between adjacent Cys residues contributes to PQQ-binding, as does a Trp residue that is part of a PQQ enzyme repeat (see pfam01011). Characterized members include the dehydrogenase subunit of a membrane-anchored, three subunit alcohol (ethanol) dehydrogenase of Gluconobacter suboxydans, a homodimeric ethanol dehydrogenase in Pseudomonas aeruginosa, and the large subunit of an alpha2/beta2 heterotetrameric methanol dehydrogenase in Methylobacterium extorquens.


Pssm-ID: 274419 [Multi-domain]  Cd Length: 527  Bit Score: 849.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083   27 VQAREVTDNDILKDGTGiTSQVVTYGLGTKGQRFSPLAKVNTSTVKNLVPVWSFSFGgeKQRGQQSQPIVFDGKMYVTAS 106
Cdd:TIGR03075   1 AAAAAVTNEDLLNDAKD-PSDWLTYGGGYAGQRYSPLDQINTDNVKKLQPAWTFSLG--KQRGQESQPLVVDGVMYVTTS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  107 YSRIFALDMKTGEKLWKYEHRLPEGIMP--CCDVINRGAAIYGNLVIFGTLDAQLVALDKDTGKVVWKEKIEDYKGGYSF 184
Cdd:TIGR03075  78 YSRVYALDAKTGKILWKYDPKLPDDIIPvmCCDVVNRGAALYDGKVFFGTLDARLVALDAKTGKVVWSKKNGDYKKGYTI 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  185 TAAPQIVKGMVITGVSGGEFGIVGKVEARDAKTGKLVWSRPTVEGNMGYKYDKDGKeiengVSGTTNA-TWPGDLWKSGG 263
Cdd:TIGR03075 158 TAAPLVVKGKVITGISGGEFGVRGYVTAYDAKTGKLVWRRYTVPGDMGYLKKTGKP-----VGGDPGAkTWPGDAWKTGG 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  264 AAPWLSAYYDPEVNLIFIGTGNPAPWNSWLRPGDNLYSSSTVAIDPDTGKIVWHYQTTPHDGWDFDGVNEFVSFDYKdpK 343
Cdd:TIGR03075 233 GATWGTGSYDPETNLIYFGTGNPAPWNSHLRPGDNLYTSSIVARDPDTGKIKWHYQTTPHDEWDYDGVNEMILFDLK--K 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  344 TGKMVKAGGKADRNGFFFVNDRTNGKLLNAFPFVNRHDWADRIDLATGRPVYNDSKRPPnpfveggEGKKGESIFAAPSF 423
Cdd:TIGR03075 311 DGKPRKLLAHADRNGFFYVLDRTNGKLLSAEPFVDKVNWATGVDLKTGRPIEVPEARST-------DGKKGKPVEVCPGF 383

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  424 LGGKNQMPMAYSPKTGYFYVPSNEWGMDIWNEPVSYKRGAAYLGAGFTIKPLNDDYIGALRAVDPVSGKIMWEVKNNAPL 503
Cdd:TIGR03075 384 LGGKNWQPMAYSPKTGLFYVPANHVCMDYWPEKVSYKKGAAYLGAGFTIKPPPDDHIGSLIAWDPITGKIVWEHKEDFPL 463

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505248083  504 WGGVLATGGDLVFYGTPEGYLKAINAKTGAELWKFQTGSGIIAPPITWEDNGEQYVAVVSGWGG 567
Cdd:TIGR03075 464 WGGVLATAGDLVFTGTLEGYFKAFDAKTGEELWKFKTGSGIVGPPVTYEQDGKQYVAVLSGWGG 527
Gcd COG4993
Glucose dehydrogenase, PQQ-dependent [Carbohydrate transport and metabolism];
45-594 0e+00

Glucose dehydrogenase, PQQ-dependent [Carbohydrate transport and metabolism];


Pssm-ID: 444017 [Multi-domain]  Cd Length: 515  Bit Score: 721.56  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  45 TSQVVTYGLGTKGQRFSPLAKVNTSTVKNLVPVWSFSFGGEKQRGQQSQPIVFDGKMYVTASYSRIFALDMKTGEKLWKY 124
Cdd:COG4993    2 PGDWLAYGGDYAGQRYSPLDQINPDNVKKLKVAWTFSTGDLPERGHEATPLVVDGVLYVCTPHNRVFALDAATGKELWRY 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 125 EHRLPEGIMpCCDVINRGAAIYGNLVIFGTLDAQLVALDKDTGKVVWKEKIEDYKGGYSFTAAPQIVKGMVITGVSGGEF 204
Cdd:COG4993   82 DPKLPDDAA-CCDVVNRGVAYYDGRIFLGTLDGRLVALDAKTGKVCWDVKVGDPKKGYTITSAPLVVKDKVIVGGSGGEF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 205 GIVGKVEARDAKTGKLVWSRPTVEGNMGYKYDkdgkeiengvsgttnaTWP-GDLWKSGGAAPWLSAYYDPEVNLIFIGT 283
Cdd:COG4993  161 GPRGVVRAYDARTGKLVWRFDTIPDPGEPGAE----------------TWPpGDTWKRGGGNVWGTMSYDPELGLVYLPT 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 284 GNPAP-WNSWLRPGDNLYSSSTVAIDPDTGKIVWHYQTTPHDGWDFDGVNEFVSFDYkdPKTGKMVKAGGKADRNGFFFV 362
Cdd:COG4993  225 GNPAPdWNGGQRPGDNLYSSSIVALDADTGELKWHYQTVPHDLWDYDGPNEPILVDL--PVDGKTRKALVQATKNGFIYV 302

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 363 NDRTNGKLLNAFPFVNRHDWADRIDLATGRPVYNdskrPPnpfveggeGKKGESIFAAPSFLGGKNQMPMAYSPKTGYFY 442
Cdd:COG4993  303 LDRETGEPLVTQPFVKPPNWATEIDMWGATPIQT----PP--------SLDGKTTLICPGALGGKNWGPAAYDPETGLLY 370

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 443 VPSNEWGMDIWNEPVSYKRGAAYLGAGFTIKPLNDDYIGALRAVDPVSGKIMWEVKNNAPLWGGVLATGGDLVFYGTPEG 522
Cdd:COG4993  371 VPANELCMDYELVPREYQAGAPYLGATLTMYPCPAPPWGTLTAIDLNTGKIVWQVPLGFPNWGGPLATAGGLVFIGTLDG 450

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 505248083 523 YLKAINAKTGAELWKFQTGSGIIAPPITWEDNGEQYVAVVSGWGGAVPLWGGdvakrvnmLEQGGSVWVFKL 594
Cdd:COG4993  451 YLRAFDAKTGKELWKFRLPSGGQATPMTYEVDGKQYVAVAAGGGGWLGLGLY--------TPQGDYLIAFAL 514
PQQ_MDH cd10278
Large subunit of methanol dehydrogenase (moxF); Methanol dehydrogenase is a key enzyme in the ...
 57-594 1.81e-180

Large subunit of methanol dehydrogenase (moxF); Methanol dehydrogenase is a key enzyme in the utilization of C1 compounds as a source of energy and carbon by bacteria. It catalyzes the oxidation of methanol to formaldehyde, transfering two electrons per methanol to cytochrome c(L) as the acceptor. Methanol dehydrogenase belongs to a family of dehydrogenases with pyrroloquinoline quinone (PQQ) as cofactor, which also includes dehydrogenases specific to other alcohols and membrane-bound glucose dehydrogenases. This alignment model for the large subunit contains an 8-bladed beta-propeller; the functional enzyme forms a heterotetramer composed of two large and two small subunits.


Pssm-ID: 199836 [Multi-domain]  Cd Length: 553  Bit Score: 521.12  E-value: 1.81e-180
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  57 GQRFSPLAKVNTSTVKNLVPVWSFSFGgeKQRGQQSQPIVFDGKMYVTASY-SRIFALDMKTGEK-LWKYEHRLPEGIMP 134
Cdd:cd10278   10 NTRYSPLAQINKDNVKNLKVAWTFSTG--VLRGHEGAPLVVGDTMYVVTPFpNNVYALDLNDPGKiLWKYKPKQDPSAVA 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 135 --CCDVINRGAAIYGNLVIFGTLDAQLVALDKDTGKVVWKEKIEDYKGGYSFTAAPQIVKGMVITGVSGGEFGIVGKVEA 212
Cdd:cd10278   88 vaCCDVVNRGLAYADGKIFFNQLDGHLVALDAKTGKEVWKVKNGDPKVGETLTMAPLVVKDKVIVGISGGEFGVRGYVTA 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 213 RDAKTGKLVWSR----PTVEGNMGYKYDKDGKEIENGVSGTTnaTWPGDLWKSGGAAPWLSAYYDPEVNLIFIGTGNPAP 288
Cdd:cd10278  168 YDLKTGKLVWRAystgPDKDVLIGPDFNPFNPHDGGKDLGLS--TWPGDAWKIGGGTNWGWYSYDPKLNLVYYGTGNPGP 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 289 WNSWLRPGDNLYSSSTVAIDPDTGKIVWHYQTTPHDGWDFDGVNEFVSFDYkdPKTGKMVKAGGKADRNGFFFVNDRTNG 368
Cdd:cd10278  246 WNPTQRPGDNKWSMTIFARDPDTGEAKWAYQMTPHDEWDYDGVNEMILVDQ--TVDGKKRKLLVHFDRNGFVYTLDRTTG 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 369 KLLNAFPFVNRhDWADRIDLATGRPVYNDSKRPpnpfvegGEGKKGESIFaaPSFLGGKNQMPMAYSPKTGYFYVPSNEW 448
Cdd:cd10278  324 ELLSAEKFDPV-NNWKGVDLKTGRPVKDPEKST-------HMDHNVTDIC--PSAMGGKDQQPSSYSPKTGLFYVPTNHL 393

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 449 GMDIWNEPVSYKRGAAYLGAGFTIKPLNDDYIGALRAVDPVSGKIMWEVKNNAPLWGGVLATGGDLVFYGTPEGYLKAIN 528
Cdd:cd10278  394 CMDYEPFEVNYTAGQPYVGATLAMYPGPGGHMGQFKAWDPVTGKTKWEIKERFPVWSGTLATAGGLVFYGTLDGWFKAVD 473

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 529 AKTGAELWKFQTGSGIIAPPITWEDNGEQYVAVVSGWGG--AVPLWGGD------------VAKRVNMLEQGGSVWVFKL 594
Cdd:cd10278  474 AKTGKLLWKFKLPSGIIGNPITYKHDGKQYVAVLSGVGGwaGVGVAAGLrdptaglgavgaFKDLPNYTQMGGTLYVFSL 553
PQQ_ADH_II cd10279
PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); This family of ...
 50-594 1.41e-172

PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); This family of monomeric and soluble type II alcohol dehydrogenases utilizes pyrroloquinoline quinone (PQQ) as a cofactor and is related to ethanol, methanol, and membrane-bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller.


Pssm-ID: 199837 [Multi-domain]  Cd Length: 549  Bit Score: 501.02  E-value: 1.41e-172
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  50 TYGLGTKGQRFSPLAKVNTSTVKNLVPVWSFSFGGEkqRGQQSQPIVFDGKMYVTASYSRIFALDMKTGEKLWKYEHRLP 129
Cdd:cd10279    5 SYGRDYDEQRFSPLTQINRSNVGQLGLAWYFDLDTN--RGQEATPLVVDGVMYVSGPWSVVYALDARTGKLLWQYDPEVD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 130 EGIM--PCCDVINRGAAIYGNLVIFGTLDAQLVALDKDTGKVVWKEKIEDYKGGYSFTAAPQIVKGMVITGVSGGEFGIV 207
Cdd:cd10279   83 RESGrkACCDVVNRGVAVWDGKVFVGTLDGRLIALDAKTGKEVWSVDTIDPRKPYTITGAPRVAKGKVVIGNGGAEFGVR 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 208 GKVEARDAKTGKLVWSRPTVEGNmgyKYDKDGKEIENGVSGTTnatWPGDLWKSG-GAAPWLSAYYDPEVNLIFIGTGNP 286
Cdd:cd10279  163 GYVSAYDAETGKLVWRFYTVPGN---PAKPFEHASLEAAAATW---WTGEWWRTGgGGTVWDSITYDPELDLLYIGTGNG 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 287 APWNSWLRP---GDNLYSSSTVAIDPDTGKIVWHYQTTPHDGWDFDGVNEFVSFDYkdPKTGKMVKAGGKADRNGFFFVN 363
Cdd:cd10279  237 SPWNRKVRSpggGDNLFLSSIVALDADTGRYKWHYQTTPGDTWDYTATQPIILADL--EIDGKPRKVLMHAPKNGFFYVL 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 364 DRTNGKLLNAFPFVnRHDWADRIDLATGRPVYNDSKR-PPNPFVeggegkkgesifAAPSFLGGKNQMPMAYSPKTGYFY 442
Cdd:cd10279  315 DRATGKLLSAEPFV-PVNWATGIDLKTGRPIENPEARyTKGPKL------------VFPGPLGAHNWHPMSYNPDTGLVY 381

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 443 VPSNEWGMDIWNEPVSYKR--GAAYLGAGFTIKPLNDDYI--------GALRAVDPVSGKIMWEVKNNAPLWGGVLATGG 512
Cdd:cd10279  382 IPAQEIPAVYEDDPGDFGYnpLGWNTGITPDATPPPAAAKralrkatrGRLVAWDPVTQKAAWRVEHPGPWNGGVLATAG 461

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 513 DLVFYGTPEGYLKAINAKTGAELWKFQTGSGIIAPPITWEDNGEQYVAVVSGWGGAVPLWGGDVA---KRVNMleqgGSV 589
Cdd:cd10279  462 NLVFQGTADGELAAYDARTGEKLWSFDTGSGIVAAPMTYSVDGEQYVAVLAGWGGAGALSGGPPGaagKVQNP----GRL 537


                 ....*
gi 505248083 590 WVFKL 594
Cdd:cd10279  538 LVFKL 542
PQQ_DH_like cd00216
PQQ-dependent dehydrogenases and related proteins; This family is composed of dehydrogenases ...
 71-593 1.60e-156

PQQ-dependent dehydrogenases and related proteins; This family is composed of dehydrogenases with pyrroloquinoline quinone (PQQ) as a cofactor, such as ethanol, methanol, and membrane-bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller, and the family also includes distantly related proteins which are not enzymatically active and do not bind PQQ.


Pssm-ID: 199833 [Multi-domain]  Cd Length: 434  Bit Score: 455.91  E-value: 1.60e-156
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  71 VKNLVPVWSFSFGGEKQRGQQSQPIVFDGKMYVTASYSRIFALDMKTGEKLWKYEHRLPEG-IMPCCDVINRGAAIYGNL 149
Cdd:cd00216    4 VFQLTPAWSFSTGDGGNRGSELTPIVVDGVMYATTSFSRVFALDADDGKEIWSYDPALKDGwFEACCDLVNRGVAVWGGK 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 150 VIFGTLDAQLVALDKDTGKVVWKEKIEDYKGGYSFTAAPQIVKGMVITGVSGGEFGIVGKVEARDAKTGKLVWSRPTVEG 229
Cdd:cd00216   84 VYIGVLDGRVYALNAETGKVAWKVKNADVLGGYTATSAPVVVDGLVIIGSSGDEFGVRGYLTAYDVATGEEKWRFYLVMP 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 230 NMGYKYDKDGKEIengvsGTTNATWPGDLWKSGGAAPWLSAYYDPEVNLIFIGTGNPAPWNSW--LRPGDNLYSSSTVAI 307
Cdd:cd00216  164 DPNLLPGKDSTVT-----DRNTPTGDEHTWTSGGGTGWSSAAYDAELNLIYVGGGNPTPWNWGgnRTPGDNLYTSSIVAV 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 308 DPDTGKIVWHYQTTPHDGWDFDGVNEFVSFDYKDpkTGKMVKAGGKADRNGFFFVNDRTNGKLLNAFPFVnrhdwadrid 387
Cdd:cd00216  239 NADTGEMKWQYQTTPHDAWDYDGDNTPVLADIKV--KGKKVKVLFAPAKNGNFYVLDRRNGELVSARPLV---------- 306

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 388 latgrpvyndskrppnpfveggegkkgesifaapsflggknqmPMAYSPKTGYFYVPSNewgmdiwnepvsykrgaaylg 467
Cdd:cd00216  307 -------------------------------------------PDSYDPDRELFYVPAN--------------------- 322

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 468 agftikplnddyiGALRAVDPVSGKIMWEVKNNAPLWGGVLATGGDLVFYGTPEGYLKAINAKTGAELWKFQTGSGIIAP 547
Cdd:cd00216  323 -------------GRIMALDPVTGVVVWEKSELHPLLGGPLSTAGNLVFVGTSDGYLKAYNADTGEKLWQQKVPSGFQAE 389

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*.
gi 505248083 548 PITWEDNGEQYVAVVSGWGGAVPLWGGdVAKRVNMLEQGGSVWVFK 593
Cdd:cd00216  390 PVTYEVDGEQYVLIQAGGGGAFPLWGG-MADLTRGTQMGGTVVVYK 434
PQQ_mGDH cd10280
Membrane-bound PQQ-dependent glucose dehydrogenase; This bacterial subfamily of enzymes ...
 50-567 1.34e-76

Membrane-bound PQQ-dependent glucose dehydrogenase; This bacterial subfamily of enzymes belongs to the dehydrogenase family with pyrroloquinoline quinone (PQQ) as cofactor, and is the only subfamily that is bound to the membrane. Glucose dehydrogenase converts D-glucose to D-glucono-1,5-lactone in a reaction that is coupled with the respiratory chain in the periplasmic oxidation of sugars and alcohols in gram-negative bacteria. Ubiquinone functions as the electron acceptor. The alignment model contains an 8-bladed beta-propeller.


Pssm-ID: 199838 [Multi-domain]  Cd Length: 616  Bit Score: 255.19  E-value: 1.34e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  50 TYGLGTKGQRFSPLAKVNTSTVKNLVPVWSFSFGGEKQRGQ-----QSQPIVFDGKMYVTASYSRIFALDMKTGEKLWKY 124
Cdd:cd10280    3 AYGGDPGGTRYSPLDQITPDNVGKLKVAWTYHTGDLPGPDGnegtfEATPLKVGGTLYLCTPHNRVIALDAATGKELWRF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 125 E----HRLPEGIMPCcdvinRGAAIY---------GNLVIFGTLDAQLVALDKDTGKVVW----------KEKIEDYK-G 180
Cdd:cd10280   83 DpkagADAAPGHQTC-----RGVSYWedgaaaaacARRIFFGTGDARLIALDARTGKPCPdfgdngvvdlREGLGRVKpG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 181 GYSFTAAPQIVKGMVITGVSGGEFGIV----GKVEARDAKTGKLVWSRPTVEGNMGYKYDKDGkeiENGVSGTTNAtwpg 256
Cdd:cd10280  158 FYSSTSPPTVYGDLVIVGSAVADNQAVdapsGVIRAFDVRTGKLVWAFDTIPPPGEAGPDTAG---AWYTRGGPNV---- 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 257 dlwksggaapWLSAYYDPEVNLIFIGTGNPAP--WNSwLRPGDNLYSSSTVAIDPDTGKIVWHYQTTPHDGWDFDGVNEF 334
Cdd:cd10280  231 ----------WAGMSADEKLGLVYLPTGSATPdfYGG-DRPGDNLFANSLVALDAATGKRRWHFQTVHHDLWDYDLPAQP 299

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 335 VSFDYKDPktGKMVKAGGKADRNGFFFVNDRTNGKLL------------------------------NAFPFVNRHDWAD 384
Cdd:cd10280  300 TLVDVPRD--GKTVPAVAQPTKQGFVFVLDRRTGKPLwpveerpvpqgdvpgertsptqpfptlpppFARQGLTEDDMWG 377

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 385 R--IDLATGRpVYNDSKR------PPnpfveggeGKKGESIFaaPSFLGGKNQMPMAYSPKTGYFYVPSNEWGMDIWNEP 456
Cdd:cd10280  378 AtpFDQLACR-IQFRSLRyeglftPP--------SLDGTLIF--PGNDGGANWGGAAVDPERGILYVNSNRLPFVIQLVP 446

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 457 V------SYKRGAAYLGAGFTIKPLNDDYI--------------------GALRAVDPVSGKIMWEVKN----------- 499
Cdd:cd10280  447 RapgdpaGVAGGGEGGGGGGGPSPQAGTPYgvgrgrflsplglpcqappwGTLTAIDLNTGKILWQVPLgtvpdlgpkgi 526

                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505248083 500 ------NAPLWGGVLATGGDLVFYG-TPEGYLKAINAKTGAELWKFQTGSGIIAPPITWEDNGEQYVAVVSGWGG 567
Cdd:cd10280  527 plpiptGTPNLGGPVVTAGGLVFIAaTQDNYLRAFDKATGKELWEARLPAGGQATPMTYEVDGKQYVVIAAGGHG 601
PQQ_membr_DH TIGR03074
membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; This protein ...
 51-575 2.16e-46

membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; This protein family has a phylogenetic distribution very similar to that coenzyme PQQ biosynthesis enzymes, as shown by partial phylogenetic profiling. Members of this family have several predicted transmembrane helices in the N-terminal region, and include the quinoprotein glucose dehydrogenase (EC 1.1.5.2) of Escherichia coli and the quinate/shikimate dehydrogenase of Acinetobacter sp. ADP1 (EC 1.1.99.25). Sequences closely related except for the absense of the N-terminal hydrophobic region, scoring in the gray zone between the trusted and noise cutoffs, include PQQ-dependent glycerol (EC 1.1.99.22) and and other polyol (sugar alcohol) dehydrogenases.


Pssm-ID: 274418 [Multi-domain]  Cd Length: 764  Bit Score: 174.42  E-value: 2.16e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083   51 YGLGTKGQRFSPLAKVNTSTVKNLVPVWSFSFGGEKQRGQ------QSQPIVFDGKMYVTASYSRIFALDMKTGEKLWKY 124
Cdd:TIGR03074 141 YGRTQAGQRYSPLDQINPDNVGNLKVAWTYHTGDLKTPDDpgeatfQATPLKVGDTLYLCTPHNKVIALDAATGKEKWKF 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  125 EHRLPEGIMP----CcdvinRGAAIY------------------GNLVIFGTLDAQLVALDKDTGK----------VVWK 172
Cdd:TIGR03074 221 DPKLKTEADRqhqtC-----RGVSYYdapaaaagpagpaapadcARRIILPTSDARLIALDADTGKlcedfgnngtVDLT 295

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  173 EKIEDYK-GGYSFTAAPQIVKGMVITG------VSGGEFGivGKVEARDAKTGKLVWsrptvegnmgyKYDKDGKEIeng 245
Cdd:TIGR03074 296 AGMGPTPpGYYYPTSPPLVAGTTVVIGgrvadnYSTDEPS--GVIRAFDVNTGALVW-----------AWDPGNPDP--- 359

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  246 vsgtTNATWPGDLWKSGGAAPWLSAYYDPEVNLIFIGTGNPAP--WNSWLRPGDNLYSSSTVAIDPDTGKIVWHYQTTPH 323
Cdd:TIGR03074 360 ----TAPPAPGETYTRNSPNSWSVASYDEKLGLVYLPMGNQTPdqWGGDRTPADEKYSSSLVALDATTGKERWVFQTVHH 435

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  324 DGWDFDGVNEFVSFDYKDpKTGKMVKAGGKADRNGFFFVNDRTNGKLLNAFPFVN------RHDWAD----RIDLATGRP 393
Cdd:TIGR03074 436 DLWDMDVPAQPSLVDLPK-ADGTTVPALVAPTKQGQIYVLDRRTGEPIVPVEEVPvpqgavPGERYSptqpFSVLTFGPP 514

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  394 VYNDSK-------------------RPPNPFVEGGEgkKGESIFaaPSFLGGKNQMPMAYSPKTGYFYVPSNEWG----- 449
Cdd:TIGR03074 515 TLTESDmwgatpfdqlacriqfkslRYEGLYTPPSE--QGSLVF--PGNLGGFNWGGVAVDPTRQVMFVNPMRLPfvsql 590

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  450 --MDIWNEP------------VSYKRGAAYlgaGFTIKPLNDDY--------IGALRAVDPVSGKIMWEVKNNA------ 501
Cdd:TIGR03074 591 vpRAPGDEApsgakgkgtemgLNPNKGTPY---AVNMNPFLSPLgipcqappWGYMAAIDLKTGKVVWQHPNGTvrdtgp 667

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  502 -------------PLWGGVLATGGDLVFYG-TPEGYLKAINAKTGAELWKFQTGSGIIAPPITW-EDNGEQYVAVVSGWG 566
Cdd:TIGR03074 668 mgipmplpipigvPTLGGPLATAGGLVFIGaTQDNYLRAYDLSTGKELWEARLPAGGQATPMTYmGKDGKQYVVIVAGGH 747


                  ....*....
gi 505248083  567 GAVPLWGGD 575
Cdd:TIGR03074 748 GSSGTKRGD 756
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 61-223 3.38e-16

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 80.63  E-value: 3.38e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  61 SPLAKVnTSTVKnLVPVWSFSFG-GEKQRGQQSQPIVFDGKMYVTASYSRIFALDMKTGEKLWKYEHRLPegimpccdvI 139
Cdd:COG1520   21 APLPEF-EPSVK-VKQLWSASVGdGVGKGYSRLAPAVAGDRVYAADADGRVAALDAATGKELWRVDLGEP---------L 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 140 NRGAAIYGNLVIFGTLDAQLVALDKDTGKVVWKEKIedykgGYSFTAAPQIVKGMVItgVSGGEfgivGKVEARDAKTGK 219
Cdd:COG1520   90 SGGVGADGGLVVVGTEDGEVIALDADDGEELWRARL-----SSEVLAAPAVAGGRVV--VRTGD----GRVYALDAATGE 158


                 ....
gi 505248083 220 LVWS 223
Cdd:COG1520  159 RLWS 162
BamB_YfgL cd10276
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ...
 78-318 3.62e-15

Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.


Pssm-ID: 199834 [Multi-domain]  Cd Length: 358  Bit Score: 77.37  E-value: 3.62e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  78 WSFSFGGEKQRGQQSQPIVFDGKMYVTASYSRIFALDMKTGEKLWKYEhrLPEGIMpccdviNRGAAIYGNLVIF-GTLD 156
Cdd:cd10276   18 WSKSVGNGGMAGIDLTPVVAGDMVYAADANGQVSAFNATTGKIIWETS--LSGKGF------LGGTPAVGNGKIFvGTES 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 157 AQLVALDKDTGKVVWKEKIEDykggYSFTAAPQIVKGMVITGVSGgefgivGKVEARDAKTGKLVWSR--PTVEGNMGYK 234
Cdd:cd10276   90 GYLYALDAKDGSELWRTEVSD----SQLLSPPTYADGKIYVGTGD------GRLYYCNAETGKVVWNRtsTAPELSLRGG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 235 Y---DKDGKEIENGVSGTTNATWPGD---LWKSGGAAPWL----------SAYYDPEVNLIFIGTGNPAPWNSWLRPGDN 298
Cdd:cd10276  160 AapvGAYDVVFVGDGNGTVVALNTGTgvdIWEFSVSEPRGrtelprmidsSVTYVVVGGYLYSTSYQGYLVALDFESGQF 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 505248083 299 LYS------SSTVAI-----------------DPDTGKIVWHY 318
Cdd:cd10276  240 LWSrkasggTSTSTDangrvyvgdgegslyclDASTGDELWSQ 282
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 61-223 2.06e-14

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 74.97  E-value: 2.06e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083   61 SPLAKVnTSTVKNLVpVWSFSFG-GEKQRGQQSQPIVFDGKMYVTASYSRIFALDMKTGEKLWKYEHRLPegimpccdvI 139
Cdd:TIGR03300  29 AELPEF-QPTVKVDQ-VWSASVGdGVGHYYLRLQPAVAGGKVYAADADGTVAALDAETGKRLWRVDLDER---------L 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  140 NRGAAIYGNLVIFGTLDAQLVALDKDTGKVVWKEKIedykgGYSFTAAPQIVKGMVItgVSGGEfgivGKVEARDAKTGK 219
Cdd:TIGR03300  98 SGGVGADGGLVFVGTEKGEVIALDAEDGKELWRAKL-----SSEVLSPPLVANGLVV--VRTND----GRLTALDAATGE 166


                  ....
gi 505248083  220 LVWS 223
Cdd:TIGR03300 167 RLWT 170
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 478-548 9.38e-13

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 69.96  E-value: 9.38e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505248083  478 DYIGALRAVDPVSGKIMWEVKNNAPLWGGVlATGGDLVFYGTPEGYLKAINAKTGAELWKFQTGSGIIAPP 548
Cdd:TIGR03300  72 DADGTVAALDAETGKRLWRVDLDERLSGGV-GADGGLVFVGTEKGEVIALDAEDGKELWRAKLSSEVLSPP 141
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 76-225 1.13e-12

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 67.81  E-value: 1.13e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083   76 PVWSFSFGGEkqrgQQSQPIVFDGKMYVTASYSRIFALDMKTGEKLWKYEHRLPEGIMpccdVINRGAAIYGNLVIFGTL 155
Cdd:pfam13360  55 LLWRQTLSGE----VLGAPLVAGGRVFVVAGDGSLIALDAADGRRLWSYQRSGEPLAL----RSSGSPAVVGDTVVAGFS 126

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505248083  156 DAQLVALDKDTGKVVWKEKIEDYKGGYSF------TAAPQIVKGMVItgVSGGEfgivGKVEARDAKTGKLVWSRP 225
Cdd:pfam13360 127 SGKLVALDPATGKVRWEAPLAAPRGTNELerlvdiTGTPVVAGGRVF--ASAYQ----GRLVAFDAATGRRLWTRE 196
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 77-316 1.50e-12

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 67.43  E-value: 1.50e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083   77 VWSFSFGGEKQRGqqsqPIVFDGKMYVTASYSRIFALDMKTGEKLWKYehRLPEGImpccdvinRGA-AIYGNLVIFGTL 155
Cdd:pfam13360  16 LWRVDLETGLGGG----VAVDGGRLFVATGGGQLVALDAATGKLLWRQ--TLSGEV--------LGApLVAGGRVFVVAG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  156 DAQLVALDKDTGKVVWKEKIEDYKGGYSFTAAPQIVKGMVITGVSGgefgivGKVEARDAKTGKLVWSRPTVEgnmgyky 235
Cdd:pfam13360  82 DGSLIALDAADGRRLWSYQRSGEPLALRSSGSPAVVGDTVVAGFSS------GKLVALDPATGKVRWEAPLAA------- 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  236 DKDGKEIENGVSGT-TNATWPGDLWKSGGAAPWLSayYDpevnlifIGTGNPapwnSWLRP----------GDNLYSSST 304
Cdd:pfam13360 149 PRGTNELERLVDITgTPVVAGGRVFASAYQGRLVA--FD-------AATGRR----LWTREisgpngpildGDLLYVVSD 215

                         250
                  ....*....|....*.
gi 505248083  305 ----VAIDPDTGKIVW 316
Cdd:pfam13360 216 dgelYALDRATGAVVW 231
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 92-225 2.40e-11

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 65.61  E-value: 2.40e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  92 SQPIVFDGKMYVTASYSRIFALDMKTGEKLWKYEHRLPEGIMpccdvinRGAA---IYGNLVIFGTLDAQLVALDKDTGK 168
Cdd:COG1520  131 AAPAVAGGRVVVRTGDGRVYALDAATGERLWSYQRPVPALTL-------RGTSspvIVGGAVLVGFANGKLVALDLANGQ 203

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 169 VVWKEKIedykggysftAAPqivKG------MV-ITG---VSGGEFGIV---GKVEARDAKTGKLVWSRP 225
Cdd:COG1520  204 PLWEQRV----------AQP---RGrtelerLVdVDGtpvVDGGVVYAVayqGRLAALDLRSGRVLWSRD 260
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 452-548 5.17e-11

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 64.45  E-value: 5.17e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 452 IWNEPVsykrGAAYLGAGFTIKP-LNDDYI------GALRAVDPVSGKIMWEVKNNAPLWGGVlATGGDLVFYGTPEGYL 524
Cdd:COG1520   35 LWSASV----GDGVGKGYSRLAPaVAGDRVyaadadGRVAALDAATGKELWRVDLGEPLSGGV-GADGGLVVVGTEDGEV 109

                         90       100
                 ....*....|....*....|....
gi 505248083 525 KAINAKTGAELWKFQTGSGIIAPP 548
Cdd:COG1520  110 IALDADDGEELWRARLSSEVLAAP 133
PRK11138 PRK11138
outer membrane biogenesis protein BamB; Provisional
 60-231 1.53e-10

outer membrane biogenesis protein BamB; Provisional


Pssm-ID: 236857 [Multi-domain]  Cd Length: 394  Bit Score: 63.41  E-value: 1.53e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  60 FSPLAKVN---TSTVknlvpVWSFSFG-GEKQRGQQSQPIVFDGKMYVTASYSRIFALDMKTGEKLWKYEHRLPEGIMPC 135
Cdd:PRK11138  32 MSPLPQVEnqfTPTT-----VWSTSVGdGVGDYYSRLHPAVAYNKVYAADRAGLVKALDADTGKEIWSVDLSEKDGWFSK 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 136 cdviNRGAAIYG------NLVIFGTLDAQLVALDKDTGKVVWKEKIedykGGYSFtAAPQIVKGMVITGVSGgefgivGK 209
Cdd:PRK11138 107 ----NKSALLSGgvtvagGKVYIGSEKGQVYALNAEDGEVAWQTKV----AGEAL-SRPVVSDGLVLVHTSN------GM 171

                        170       180
                 ....*....|....*....|..
gi 505248083 210 VEARDAKTGKLVWsrpTVEGNM 231
Cdd:PRK11138 172 LQALNESDGAVKW---TVNLDV 190
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 92-240 5.57e-10

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 61.49  E-value: 5.57e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083   92 SQPIVFDGKMYVTASYSRIFALDMKTGEKLWKYEHRLPEGIMpccdvinRGAA---IYGNLVIFGTLDAQLVALDKDTGK 168
Cdd:TIGR03300 139 SPPLVANGLVVVRTNDGRLTALDAATGERLWTYSRVTPPLTL-------RGSAspvIADGGVLVGFAGGKLVALDLQTGQ 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  169 VVWKEKIEDYKGGYSF------TAAPqIVKGMVITGVSggefgIVGKVEARDAKTGKLVWSR-------PTVEGNMGYKY 235
Cdd:TIGR03300 212 PLWEQRVALPKGRTELerlvdvDGDP-VVDGGQVYAVS-----YQGRVAALDLRSGRVLWKRdassyqgPAVDDNRLYVT 285


                  ....*
gi 505248083  236 DKDGK 240
Cdd:TIGR03300 286 DADGV 290
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 108-223 2.37e-08

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 55.10  E-value: 2.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  108 SRIFALDMKTGEKLWKYEHRLPEGimpccdvinRGAAIYGNLVIFGTLDAQLVALDKDTGKVVWKEKIEDykggySFTAA 187
Cdd:pfam13360   3 GVVTALDAATGAELWRVDLETGLG---------GGVAVDGGRLFVATGGGQLVALDAATGKLLWRQTLSG-----EVLGA 68

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 505248083  188 PQIVKGMVITgVSGGefgivGKVEARDAKTGKLVWS 223
Cdd:pfam13360  69 PLVAGGRVFV-VAGD-----GSLIALDAADGRRLWS 98
PRK11138 PRK11138
outer membrane biogenesis protein BamB; Provisional
 77-224 1.08e-07

outer membrane biogenesis protein BamB; Provisional


Pssm-ID: 236857 [Multi-domain]  Cd Length: 394  Bit Score: 54.17  E-value: 1.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  77 VWSFSFGGEkqrgQQSQPIVFDGKMYVTASYSRIFALDMKTGEKLWKYEHRLPEGIMpccdvinRG----AAIYGNlVIF 152
Cdd:PRK11138 143 AWQTKVAGE----ALSRPVVSDGLVLVHTSNGMLQALNESDGAVKWTVNLDVPSLTL-------RGesapATAFGG-AIV 210

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 505248083 153 GTLDAQLVALDKDTGKVVWKEKIEDYKGGYSFT------AAPQIVKGMVITgvsggeFGIVGKVEARDAKTGKLVWSR 224
Cdd:PRK11138 211 GGDNGRVSAVLMEQGQLIWQQRISQPTGATEIDrlvdvdTTPVVVGGVVYA------LAYNGNLVALDLRSGQIVWKR 282
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 481-548 1.94e-07

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 52.41  E-value: 1.94e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 505248083  481 GALRAVDPVSGKIMWEVKNNAPLWGGVlATGGDLVFYGTPEGYLKAINAKTGAELWKFQTGSGIIAPP 548
Cdd:pfam13360   3 GVVTALDAATGAELWRVDLETGLGGGV-AVDGGRLFVATGGGQLVALDAATGKLLWRQTLSGEVLGAP 69
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 71-223 3.77e-07

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 51.25  E-value: 3.77e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083   71 VKNLVPVWSFSFGGEKQR-GQQSQPIVFDGKMYVTASYSRIFALDMKTGEKLWKYEHRLPEGIMPCCDV--INRGAAIYG 147
Cdd:pfam13360  90 AADGRRLWSYQRSGEPLAlRSSGSPAVVGDTVVAGFSSGKLVALDPATGKVRWEAPLAAPRGTNELERLvdITGTPVVAG 169

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505248083  148 NLVIFGTLDAQLVALDKDTGKVVWKEKIEDYKGgysftaapQIVKGMVITGVSGGefgivGKVEARDAKTGKLVWS 223
Cdd:pfam13360 170 GRVFASAYQGRLVAFDAATGRRLWTREISGPNG--------PILDGDLLYVVSDD-----GELYALDRATGAVVWK 232
BamB_YfgL cd10276
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ...
 478-554 8.80e-07

Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.


Pssm-ID: 199834 [Multi-domain]  Cd Length: 358  Bit Score: 51.18  E-value: 8.80e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 505248083 478 DYIGALRAVDPVSGKIMWEVK-NNAPLWGGVLATGGDLVFYGTPEGYLKAINAKTGAELWKFQTGSGIIAPPITWEDN 554
Cdd:cd10276   45 DANGQVSAFNATTGKIIWETSlSGKGFLGGTPAVGNGKIFVGTESGYLYALDAKDGSELWRTEVSDSQLLSPPTYADG 122
PRK11138 PRK11138
outer membrane biogenesis protein BamB; Provisional
 481-590 1.84e-06

outer membrane biogenesis protein BamB; Provisional


Pssm-ID: 236857 [Multi-domain]  Cd Length: 394  Bit Score: 50.31  E-value: 1.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 481 GALRAVDPVSGKIMWEV----------KNN-APLWGGVLATGGdLVFYGTPEGYLKAINAKTGAELWKFQTGSGIIAPPI 549
Cdd:PRK11138  79 GLVKALDADTGKEIWSVdlsekdgwfsKNKsALLSGGVTVAGG-KVYIGSEKGQVYALNAEDGEVAWQTKVAGEALSRPV 157

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505248083 550 TWE-----------------DNGEQYVAV---------------VSGWGGAVplWGGDVAK-RVNMLEQGGSVW 590
Cdd:PRK11138 158 VSDglvlvhtsngmlqalneSDGAVKWTVnldvpsltlrgesapATAFGGAI--VGGDNGRvSAVLMEQGQLIW 229
PQQ pfam01011
PQQ enzyme repeat; The family represent a single repeat of a beta propeller. This propeller ...
 513-548 2.80e-06

PQQ enzyme repeat; The family represent a single repeat of a beta propeller. This propeller has been found in several enzymes which utilize pyrrolo-quinoline quinone as a prosthetic group.


Pssm-ID: 395799 [Multi-domain]  Cd Length: 36  Bit Score: 44.10  E-value: 2.80e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 505248083  513 DLVFYGTPEGYLKAINAKTGAELWKFQTGSGIIAPP 548
Cdd:pfam01011   1 GTVYLGSDDGYLYALDAETGKVLWSFKTGGAVLSSP 36
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 92-240 1.62e-05

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 47.23  E-value: 1.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083   92 SQPIVFDGKMYVTASYSRIFALDMKTGEKLWKYEHRlpegimpccdvINRGAAIYGNLVIFGTLDAQLVALDKDTGKVVW 171
Cdd:TIGR03300 235 GDPVVDGGQVYAVSYQGRVAALDLRSGRVLWKRDAS-----------SYQGPAVDDNRLYVTDADGVVVALDRRSGSELW 303

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 505248083  172 KEkiEDYKGGYsfTAAPQIVKGMVITGVSGGEFGIV----GKVEARDAKTGKLVWSRPTVEGNMGYKYDKDGK 240
Cdd:TIGR03300 304 KN--DELKYRQ--LTAPAVLGGYLVVGDFEGYLHWLdrddGSFVARLKTDGSGIASPPVVVGDGLLVQTRDGD 372
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 156-321 2.32e-05

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 45.86  E-value: 2.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  156 DAQLVALDKDTGKVVWKEKIEDYKGGysftaapqivkgmvITGVSGGEF---GIVGKVEARDAKTGKLVWSR-------- 224
Cdd:pfam13360   2 DGVVTALDAATGAELWRVDLETGLGG--------------GVAVDGGRLfvaTGGGQLVALDAATGKLLWRQtlsgevlg 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  225 -PTVEGNMGYKYDKDGKEIE-NGVSGTTnatwpgdLWksggaapwlsAYYDPEVNLIFIGTGNPAPwnswlrPGDNLY-- 300
Cdd:pfam13360  68 aPLVAGGRVFVVAGDGSLIAlDAADGRR-------LW----------SYQRSGEPLALRSSGSPAV------VGDTVVag 124

                         170       180
                  ....*....|....*....|...
gi 505248083  301 --SSSTVAIDPDTGKIVWHYQTT 321
Cdd:pfam13360 125 fsSGKLVALDPATGKVRWEAPLA 147
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 481-536 2.92e-05

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 46.46  E-value: 2.92e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  481 GALRAVDPVSGKIMWEVKNNAP---LWG-GVLATGGDLVFYGTPEGYLKAINAKTGAELW 536
Cdd:TIGR03300 155 GRLTALDAATGERLWTYSRVTPpltLRGsASPVIADGGVLVGFAGGKLVALDLQTGQPLW 214
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 481-536 6.69e-05

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 45.57  E-value: 6.69e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 481 GALRAVDPVSGKIMWEVKNNAP---LWG-GVLATGGDLVFYGTPEGYLKAINAKTGAELW 536
Cdd:COG1520  147 GRVYALDAATGERLWSYQRPVPaltLRGtSSPVIVGGAVLVGFANGKLVALDLANGQPLW 206
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 92-240 8.32e-05

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 45.19  E-value: 8.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  92 SQPIVFDGKMYVTASYSRIFALDMKTGEKLWKYEHRLPEGImpccdvinrgaAIYGNLVIFGTLDAQLVALDKDTGKVVW 171
Cdd:COG1520  227 GTPVVDGGVVYAVAYQGRLAALDLRSGRVLWSRDLSSYTGL-----------AVDGNNLYVTDDDGRVWALDRRNGAELW 295

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505248083 172 KEkiEDYKggYSFTAAPQIVKGMVitgVSGGEFGIV-------GKVEARDAKTGKLVWSRPTVEGNMGYKYDKDGK 240
Cdd:COG1520  296 KQ--DALL--YRGLTAPVVLGDYV---VVGDFEGYLhwlsrddGSLVARLRVDGSGIRAAPVVVGDTLYVQTRDGT 364
PQQ smart00564
beta-propeller repeat; Beta-propeller repeat occurring in enzymes with pyrrolo-quinoline ...
 94-124 1.65e-04

beta-propeller repeat; Beta-propeller repeat occurring in enzymes with pyrrolo-quinoline quinone (PQQ) as cofactor, in Ire1p-like Ser/Thr kinases, and in prokaryotic dehydrogenases.


Pssm-ID: 128836 [Multi-domain]  Cd Length: 33  Bit Score: 39.05  E-value: 1.65e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 505248083    94 PIVFDGKMYVTASYSRIFALDMKTGEKLWKY 124
Cdd:smart00564   2 VVLSDGTVYVGSTDGTLYALDAKTGEILWTY 32
PA2928_fam NF041516
PA2928 family protein; This family is named for the locus PA2928 of Pseudomonas aeroginosa ...
 106-202 9.33e-04

PA2928 family protein; This family is named for the locus PA2928 of Pseudomonas aeroginosa PAO1, as the family member most frequently cited in the literature, although PA2928 itself is significantly shorter at the N-terminus than most other members of this family, and is probably non-functional. WP_017001489.1 represents an intact equivalent to the PA2928 pseudogene.


Pssm-ID: 469402 [Multi-domain]  Cd Length: 345  Bit Score: 41.59  E-value: 9.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 106 SYSRIFALDMKTGEKLWKyeHRLPegimpccDVINRGAAIYG---NLVIFGTlDAQLVALDKDTGKVV-----WKEKIED 177
Cdd:NF041516  67 SQFRLAAVDLATGEKLWD--KKLS-------DELSWEAYLLGatdRYLYVAT-DKGLYVLDLATGKVVadekeLEGLGPA 136

                         90       100
                 ....*....|....*....|....*....
gi 505248083 178 YKGGYSFTAAPQIV----KGMVITGVSGG 202
Cdd:NF041516 137 LKDNLSAARAAYAYdddnRALYFYGLDGR 165
BamB_YfgL cd10276
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ...
 34-202 1.03e-03

Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.


Pssm-ID: 199834 [Multi-domain]  Cd Length: 358  Bit Score: 41.55  E-value: 1.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  34 DNDILKDGTGITSQVVTYGLGtkgqrfspLAKVNTSTVKnlvPVWSfsfggEKQRGQQSQPIVFDGKMYVTASYSRIFAL 113
Cdd:cd10276  208 DSSVTYVVVGGYLYSTSYQGY--------LVALDFESGQ---FLWS-----RKASGGTSTSTDANGRVYVGDGEGSLYCL 271

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 114 DMKTGEKLWKYehrlpegimpccDVINRG----AAIY-GNLVIFGTLDAQLVALDKDTGKVVWKEKIEDYKGGysFTAAP 188
Cdd:cd10276  272 DASTGDELWSQ------------TVLLGRvlssPAIYvGVYIYVTDNAEGYLYCLKDNDGLTVARVEVDYSQY--ILQGP 337

                        170
                 ....*....|....
gi 505248083 189 QIVKGMVITGVSGG 202
Cdd:cd10276  338 AVSDGWLYYGTDDG 351
PRK11138 PRK11138
outer membrane biogenesis protein BamB; Provisional
 91-240 1.27e-03

outer membrane biogenesis protein BamB; Provisional


Pssm-ID: 236857 [Multi-domain]  Cd Length: 394  Bit Score: 41.45  E-value: 1.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  91 QSQPIVFDGKMYVTASYSRIFALDMKTGEKLWKYEhrlpegIMPCCDVINRGAAIYgnLVifgTLDAQLVALDKDTGKVV 170
Cdd:PRK11138 249 DTTPVVVGGVVYALAYNGNLVALDLRSGQIVWKRE------YGSVNDFAVDGGRIY--LV---DQNDRVYALDTRGGVEL 317

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083 171 WKEKIEDYKggySFTaAPQIVKGMVITG----------VSGGEFgiVGKVEARDAKtgklVWSRPTVEGNMGYKYDKDGK 240
Cdd:PRK11138 318 WSQSDLLHR---LLT-APVLYNGYLVVGdsegylhwinREDGRF--VAQQKVDSSG----FLSEPVVADDKLLIQARDGT 387
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 433-543 2.11e-03

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 40.08  E-value: 2.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  433 AYSPKTGyfyvpSNEWGMDI---WNEPVSYKRGAAYLGAGFtikplnddyiGALRAVDPVSGKIMWEVKNNAPLwGGVLA 509
Cdd:pfam13360   7 ALDAATG-----AELWRVDLetgLGGGVAVDGGRLFVATGG----------GQLVALDAATGKLLWRQTLSGEV-LGAPL 70

                          90       100       110
                  ....*....|....*....|....*....|....
gi 505248083  510 TGGDLVFYGTPEGYLKAINAKTGAELWKFQTGSG 543
Cdd:pfam13360  71 VAGGRVFVVAGDGSLIALDAADGRRLWSYQRSGE 104
PQQ pfam01011
PQQ enzyme repeat; The family represent a single repeat of a beta propeller. This propeller ...
 148-183 3.55e-03

PQQ enzyme repeat; The family represent a single repeat of a beta propeller. This propeller has been found in several enzymes which utilize pyrrolo-quinoline quinone as a prosthetic group.


Pssm-ID: 395799 [Multi-domain]  Cd Length: 36  Bit Score: 35.25  E-value: 3.55e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 505248083  148 NLVIFGTLDAQLVALDKDTGKVVWKEKIEDYKGGYS 183
Cdd:pfam01011   1 GTVYLGSDDGYLYALDAETGKVLWSFKTGGAVLSSP 36
PQQ smart00564
beta-propeller repeat; Beta-propeller repeat occurring in enzymes with pyrrolo-quinoline ...
 146-172 3.65e-03

beta-propeller repeat; Beta-propeller repeat occurring in enzymes with pyrrolo-quinoline quinone (PQQ) as cofactor, in Ire1p-like Ser/Thr kinases, and in prokaryotic dehydrogenases.


Pssm-ID: 128836 [Multi-domain]  Cd Length: 33  Bit Score: 35.20  E-value: 3.65e-03
                           10        20
                   ....*....|....*....|....*..
gi 505248083   146 YGNLVIFGTLDAQLVALDKDTGKVVWK 172
Cdd:smart00564   5 SDGTVYVGSTDGTLYALDAKTGEILWT 31
BamB_YfgL cd10276
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ...
 495-564 3.72e-03

Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.


Pssm-ID: 199834 [Multi-domain]  Cd Length: 358  Bit Score: 40.01  E-value: 3.72e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505248083 495 WEVKNNAPLWGGVLATG---GDLVFYGTPEGYLKAINAKTGAELWKFQTGSGI--IAPPITweDNGEQYVAVVSG 564
Cdd:cd10276   18 WSKSVGNGGMAGIDLTPvvaGDMVYAADANGQVSAFNATTGKIIWETSLSGKGflGGTPAV--GNGKIFVGTESG 90
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 305-537 3.87e-03

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 39.31  E-value: 3.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  305 VAIDPDTGKIVWhyQTTPHDGWD------------FDGVNEFVSFDykdPKTGKMVkagGKADRNGFFFVNDRTNGKLLN 372
Cdd:pfam13360   6 TALDAATGAELW--RVDLETGLGggvavdggrlfvATGGGQLVALD---AATGKLL---WRQTLSGEVLGAPLVAGGRVF 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  373 AFPfVNRHDWAdrIDLATGRPVYNdskrppnpfVEGGEGKKGESIFAAPSFLGGKNQMP------MAYSPKTGYFyvpsn 446
Cdd:pfam13360  78 VVA-GDGSLIA--LDAADGRRLWS---------YQRSGEPLALRSSGSPAVVGDTVVAGfssgklVALDPATGKV----- 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  447 ewgmdIWNEPVSYKRGAAYLGAGFTIKP---LNDDYI------GALRAVDPVSGKIMWEVKNNAPlwGGVLATGgDLVFY 517
Cdd:pfam13360 141 -----RWEAPLAAPRGTNELERLVDITGtpvVAGGRVfasayqGRLVAFDAATGRRLWTREISGP--NGPILDG-DLLYV 212

                         250       260
                  ....*....|....*....|
gi 505248083  518 GTPEGYLKAINAKTGAELWK 537
Cdd:pfam13360 213 VSDDGELYALDRATGAVVWK 232
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 90-223 4.21e-03

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 39.80  E-value: 4.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  90 QQSQPIVFDGKMYVTASYSRIFALDMKTGEKLWkyEHRLpegimpccdVINRGA-------------AIYGNLVIFGTLD 156
Cdd:COG1520  174 GTSSPVIVGGAVLVGFANGKLVALDLANGQPLW--EQRV---------AQPRGRtelerlvdvdgtpVVDGGVVYAVAYQ 242

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505248083 157 AQLVALDKDTGKVVWKEKIEDYKGgysFTAAPQIVkgmVITGVSggefgivGKVEARDAKTGKLVWS 223
Cdd:COG1520  243 GRLAALDLRSGRVLWSRDLSSYTG---LAVDGNNL---YVTDDD-------GRVWALDRRNGAELWK 296
Luminal_IRE1_like cd09213
The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins; The ...
 98-225 9.09e-03

The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins; The Luminal domain is a dimerization domain present in Inositol-requiring protein 1 (IRE1), eukaryotic translation Initiation Factor 2-Alpha Kinase 3 (EIF2AK3), and similar proteins. IRE1 and EIF2AK3 are serine/threonine protein kinases (STKs) and are type I transmembrane proteins that are localized in the endoplasmic reticulum (ER). They are kinase receptors that are activated through the release of BiP, a chaperone bound to their luminal domains under unstressed conditions. This results in dimerization through their luminal domains, allowing trans-autophosphorylation of their kinase domains and activation. They play roles in the signaling of the unfolded protein response (UPR), which is activated when protein misfolding is detected in the ER in order to decrease the synthesis of new proteins and increase the capacity of the ER to cope with the stress. IRE1, also called Endoplasmic reticulum (ER)-to-nucleus signaling protein (or ERN), contains an endoribonuclease domain in its cytoplasmic side and acts as an ER stress sensor. It is the oldest and most conserved component of the UPR in eukaryotes. Its activation results in the cleavage of its mRNA substrate, HAC1 in yeast and Xbp1 in metazoans, promoting a splicing event that enables translation into a transcription factor which activates the UPR. EIF2AK3, also called PKR-like Endoplasmic Reticulum Kinase (PERK), phosphorylates the alpha subunit of eIF-2, resulting in the downregulation of protein synthesis. It functions as the central regulator of translational control during the UPR pathway. In addition to the eIF-2 alpha subunit, EIF2AK3 also phosphorylates Nrf2, a leucine zipper transcription factor which regulates cellular redox status and promotes cell survival during the UPR.


Pssm-ID: 188873 [Multi-domain]  Cd Length: 312  Bit Score: 38.63  E-value: 9.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505248083  98 DGKMYVTASYSRIFALDMKTGE--------KLWKYEHRLPEGIMPCCDVINrgaAIYGNLVIFGTLDAQLVALDKDTGKV 169
Cdd:cd09213   93 DDVVVVGSKRTSVFALDAKTGKiiktyradGLPSTGGSDSDGNSTPGPDEL---QEEEELLYIGRTDYVLQAIDPRSGKE 169

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 505248083 170 VWKEKIEDYKGGYSFTAAPQIVK--GMVITGVSGGEFGIVGKVEARDAKTGKLVWSRP 225
Cdd:cd09213  170 LWNVTYGEYEALTLDADELGTSSssSPLSASFRISENEPVPAVYLLGLQGGKSLWEHL 227
PQQ pfam01011
PQQ enzyme repeat; The family represent a single repeat of a beta propeller. This propeller ...
 99-125 9.41e-03

PQQ enzyme repeat; The family represent a single repeat of a beta propeller. This propeller has been found in several enzymes which utilize pyrrolo-quinoline quinone as a prosthetic group.


Pssm-ID: 395799 [Multi-domain]  Cd Length: 36  Bit Score: 34.09  E-value: 9.41e-03
                          10        20
                  ....*....|....*....|....*..
gi 505248083   99 GKMYVTASYSRIFALDMKTGEKLWKYE 125
Cdd:pfam01011   1 GTVYLGSDDGYLYALDAETGKVLWSFK 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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